Genetically Modified Organisms in Aquaculture : from Present to Future
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Salmon with a Side of Genetic Modification: the FDA's Approval of Aquadvantage Salmon and Why the Precautionary Principle Is E
Salmon with a Side of Genetic Modification: The FDA’s Approval of AquAdvantage Salmon and Why the Precautionary Principle is Essential for Biotechnology Regulation Kara M. Van Slyck* INTRODUCTION Over the last thirty years, once abundant wild salmon populations in the Pacific and Atlantic Oceans have declined to a mere fraction of their historic levels. As of 2016, salmon populations in Washington State’s Columbia River region are either failing to make any progress towards recovery or showing very little signs of improvement; Puget Sound salmon are only getting worse.1 In the Gulf of Maine, salmon populations dropped from five-hundred spawning adults in 1995 to less than fifty adults in 1999.2 Atlantic salmon, Salmo salar, were first designated as “endangered”3 in November 2000—the Fish and Wildlife Service (FWS) expanded the listing nine years later to include critical habitat along the coast of Maine as a result of little improvement to the population’s numbers.4 In the Pacific Ocean, FWS classified four significant salmon species as endangered for protection under the Endangered Species Act * Juris Doctor Candidate, Seattle University School of Law 2018. I would like to extend thanks to Professor Carmen G. Gonzalez for her valuable insight of the precautionary principle, her extensive knowledge on environmental regulations in the United States, and her unwavering support of this Note. 1. Governor’s Salmon Recovery Office, State of Salmon in Watersheds 2016, WASH. ST. RECREATION & CONSERVATION OFF., http://stateofsalmon.wa.gov/governors-report-2016/ [https:// perma.cc/6F3J-FKWE]. 2. Endangered and Threatened Species; Final Endangered Status for a Distinct Population Segment of Anadromous Atlantic Salmon (Salmo salar) in the Gulf of Maine, 50 C.F.R. -
Fifth Grade-Tennessee History and the History of the US: Industrialization to the Civil Rights Movement Quarter 4 Curriculum Map Scope and Sequence
Social Studies Quarter 4 Fifth Grade Fifth Grade-Tennessee History and the History of the US: Industrialization to the Civil Rights Movement Quarter 4 Curriculum Map Scope and Sequence Topic Week Weekly Focus Standards WWI and the Great Week 1: Students will identify the causes of the Great Depression, President Herbert Hoover’s role, and its impact on the nation, including: • 5.15, 5.16 Depression US Chapters Consumer credit and debt • Hoovervilles • Mass unemployment • Soup kitchens. Students will also describe how New Deal policies of 6 and 7 President Franklin D. Roosevelt impacted American society with government-funded programs, including: Social Security, expansion and development of the national parks, and creation of jobs. TN in the 20th Week 2: Students will describe the effects of the Great Depression on Tennessee and the impact of New Deal policies in the state (i.e., 5.48 Century TN Chapter 14 Tennessee Valley Authority and Civilian Conservation Corps). WWII Week 3: Students will explain the structures and goals of the governments in Germany and Japan in the 1930s and determine the significance of 5.17, 5.18, US Chapter 8 the bombing of Pearl Harbor and its impact on the U.S. Students will also identify and locate the Axis and Allied Powers, including: • 5.19, 5.21 Germany • Italy • Japan • France • Great Britain • Soviet Union and analyze the significance of the Holocaust and its impact on the U.S. WWII Week 4: Students will examine the reasons for the use of propaganda, rationing, and victory gardens during World War II. 5.20 US Chapter 9 TN in the 20th Week 5: Students will describe Tennessee’s contributions during World War I and World War II, including: the conversion of factories to wartime 5.49 Century TN Chapter 15 production, the importance of Oak Ridge, and the influence of Tennesseans (i.e., Cornelia Fort, Cordell Hull, and Alvin C. -
Environmental Assessment for Aquadvantage ® Salmon
Environmental Assessment for AquAdvantage Salmon Environmental Assessment for AquAdvantage® Salmon An Atlantic salmon (Salmo salar L.) bearing a single copy of the stably integrated α-form of the opAFP-GHc2 gene construct at the α-locus in the EO-1α line Aqua Bounty Technologies, Inc. Submitted to the Center for Veterinary Medicine US Food and Drug Administration For Public Display August 25, 2010 Page 1 of 84 August 25, 2010 Environmental Assessment for AquAdvantage Salmon Table of Contents (Page 1 of 4) Title Page ............................................................................................................................. 1 Table of Contents ................................................................................................................. 2 List of Tables ....................................................................................................................... 6 List of Figures ...................................................................................................................... 6 List of Acronyms & Abbreviations ..................................................................................... 7 List of Definitions ................................................................................................................ 9 Summary ............................................................................................................................. 10 1.0 INTRODUCTION .................................................................................................. -
STUDY on RISK ASSESSMENT: APPLICATION of ANNEX I of DECISION CP 9/13 to LIVING MODIFIED FISH Note by the Executive Secretary INTRODUCTION 1
CBD Distr. GENERAL CBD/CP/RA/AHTEG/2020/1/3 19 February 2020 ENGLISH ONLY AD HOC TECHNICAL EXPERT GROUP ON RISK ASSESSMENT AND RISK MANAGEMENT Montreal, Canada, 31 March to 3 April 2020 Item 3 of the provisional agenda* STUDY ON RISK ASSESSMENT: APPLICATION OF ANNEX I OF DECISION CP 9/13 TO LIVING MODIFIED FISH Note by the Executive Secretary INTRODUCTION 1. In decision CP-9/13, the Conference of the Parties serving as the meeting of the Parties to the Cartagena Protocol on Biosafety decided to establish the Ad Hoc Technical Expert Group (AHTEG) on Risk Assessment and Risk Management, which would work in accordance with the terms of reference contained in annex II to that decision. In the same decision, the Conference of the Parties serving as the meeting of the Parties to the Protocol requested the Executive Secretary to commission a study informing the application of annex I of the decision to (a) living modified organisms containing engineered gene drives and (b) living modified fish and present it to the online forum and the AHTEG. 2. Pursuant to the above, and with the financial support of the Government of the Netherlands, the Secretariat commissioned a study informing the application of annex I to living modified fish to facilitate the process referred to in paragraph 6 of decision CP-9/13. The study was presented to the Open-Ended Online Forum on Risk Assessment and Risk Management, which was held from 20 January to 1 February 2020, during which registered participants provided feedback and comments.1 3. -
2014 305(B) Report the Status of Water Quality in Tennessee
2014 305(b) Report The Status of Water Quality in Tennessee Division of Water Resources Tennessee Department of Environment and Conservation i ii 2014 305(b) Report The Status of Water Quality in Tennessee December 2014 Prepared by: Kimberly J. Laster Deborah H. Arnwine Gregory M. Denton Linda K. Cartwright Geo-Indexing of Water Quality Information by: Richard E. Cochran Tennessee Department of Environment and Conservation Division of Water Resources William R. Snodgrass-Tennessee Tower 312 Rosa L. Parks Ave., 11th Floor Nashville, TN 37243-1102 Cover Photo: Myatt Creek in Catoosa Wildlife Management Area. Photo courtesy of Brandon Chance, Cookeville Environmental Field Office, DWR. iii Table of Contents 2014 305(b) Report Page Introduction to Tennessee’s Water Quality............................................. 1 Acknowledgments................................................................................... 2 Executive Summary................................................................................ 3 Statutory Requirements........................................................................... 5 Tennessee at a Glance............................................................................. 6 Chapter 1 - Water Quality Assessment Process......................................................... 9 Chapter 2 - Water Quality Standards Attainment Status........................................... 34 Chapter 3 - Causes of Water Pollution....................................................................... 42 Chapter 4 - Sources -
Genetically Engineered Fish: an Unnecessary Risk to the Environment, Public Health and Fishing Communities
Issue brief Genetically engineered fish: An unnecessary risk to the environment, public health and fishing communities On November 19, 2015, the U.S. Food & Drug Administration announced its approval of the “AquAdvantage Salmon,” an Atlantic salmon that has been genetically engineered to supposedly be faster-growing than other farmed salmon. This is the first-ever genetically engineered animal allowed to enter the food supply by any regulatory agency in the world. At least 35 other species of genetically engineered fish are currently under development, including trout, tilapia, striped bass, flounder and other salmon species — all modified with genes from a variety of organisms, including other fish, coral, mice, bacteria and even humans.1 The FDA’s decision on the AquAdvantage genetically engineered salmon sets a precedent and could open the floodgates for other genetically engineered fish and animals (including cows, pigs and chickens) to enter the U.S. market. Genetically engineered salmon approved by FDA Despite insufficient food safety or environmental studies, the FDA announced its approval of the AquAdvantage Salmon, a genetically engineered Atlantic salmon produced by AquaBounty Technologies. The company originally submitted its application to the FDA in 2001 and the FDA announced in the summer of 2010 it was considering approval of this genetically engineered fish — the first genetically engineered animal intended for human consumption. In December 2012, the FDA released its draft Environmental Assessment of this genetically engineered salmon, and approved it in November 2015. This approval was made despite the 1.8 million people who sent letters to FDA opposing approval of the so-called “frankenfish,” and the 75 percent of respondents to a New York Times poll who said they would not eat genetically engineered salmon.2 The FDA said it would probably not require labeling of the fish; however Alaska, a top wild salmon producer, requires labeling of genetically engineered salmon and momentum is growing for GMO labeling in a number of states across the U.S. -
Transgenic Fish Technology and Its Application in Aquaculture
* TRANSGENIC FISH TECHNOLOGY AND ITS APPLICATION IN AQUACULTURE Dr . G. B. CHAND Associate Professor Department of Zoology Aquatic Toxicology laboratory Patna University, Patna Email : [email protected] * Transgenic Fishes : Introduction . Organisms into which heterologous DNA (transgene) has been artificially introduced and integrated in their genomes are called transgenics. Genetically modified fish (GM fish) are organisms from the taxonomic clade which includes the classes Agnatha (jawless fish), Chondrichthyes (cartilaginous fish) and Osteichthyes (bony fish) whose genetic material (DNA) has been altered using genetic engineering techniques. In most cases, the aim is to introduce a new trait to the fish which does not occur naturally in the species, i.e. transgenesis. GM fish are used in scientific research and kept as pets. They are being developed as environmental pollutant sentinels and for use in aquaculture food production. In 2015, the Aqua-Advantage salmon was approved by the US Food and Drug Administration (FDA) for commercial production, sale and consumption, making it the first genetically modified animal to be approved for human consumption. Some GM fish that have been created have promoters driving an over-production of "all fish" growth hormone. This results in dramatic growth enhancement in several species, including salmonids, (Shao et al.,1992) carps (Robert et al.,2001) and Tilapias(Rahman et al.,2005; Hackett and Alvarez,2000). TRANSGENIC FISHES: INTRODUCTION . The first transgenic fish were produced in China in 1985( Dunham & Winn,2014). As of 2013, approximately 50 species of fish have been subject to genetic modification. This has resulted in more than 400 fish/trait combinations. Most of the modifications have been conducted on food species, such as Atlantic salmon (Salmo solar), tilapia (genus) and common carp (Cyprinus carpio).[Menozzi et al.,2013] What can transgenic technology offer? . -
Transgenic Animals
0( (-) 00 e_ ,Z5-1 Project Number: IQP — 43 — DSA — 9195 —5904 —0822 TRANSGENIC ANIMALS An Interactive Qualifying Project Report Submitted to the faculty of the WORCESTER POLYTECHNIC INSTITUTE In partial fulfillment of the requirements for the Degree of Bachelor of Science By Nicholas Far ey Scott LeBlanc Robert Redden Date: March 2, 2000 APPROVED: 1. transgenic 2. biotechnology 3. gene transfer Professor David S. Adams Project Advisor ABSTRACT This project investigated the use of transgenic animals in recent experiments and the effects of this novel technology on society. Using scientific journals and web resources, we examined the transgenic animals in existence, their uses, and the surrounding ethical and social issues. Recommendations were offered on which experiments involving transgenic animals should be continued and how to apply this new technology to the fields of science and medicine. ii TABLE OF CONTENTS SECTION PAGE Signature Page Abstract Table of Contents iii Executive Summary vii Project Objective xi List of Illustrations xii Introduction xiii 1. BACKGROUND AND HISTORY 1 1.1 Background Information 1 1.1.1 DNA 1 1.1.2 Replication and Expression 2 1.2 History of Transgenics 3 1.2.1 Prior to the First Transgenic Animal 3 1.2.2 The First Transgenic Animals 4 1.2.3 Further Experiments in the 1980's 5 1.2.4 Experiments Spanning into the Present 7 2. CURRENT METHODS 10 2.1 Superovulation 10 2.1.1 Choice of Parental Donor Strain 10 2.1.2 Hormone Cycle 11 2.1.3 Methods of Superovulation 13 iii 2.1.4 Flushing 14 2.2 Methods of Gene Transfer 17 2.2.1 Obtaining Recombinant DNA 17 2.2.2 Retroviral Vectors 19 2.2.3 Microinjection 20 2.2.4 Embryonic Stem Cells for Injections 22 2.2.5 Cultured Sperm Cells as Vectors 27 2.3 Transgenic Embryo Implantation 27 2.3.1 Embryo Inspection 27 2.3.2 Embryo Implantation Methods 28 2.3.3 Testing and Breeding 30 3. -
The Development of Genetically Modified (GM) Salmon in Canada
The Development of Genetically Modified (GM) Salmon in Canada In late 2013, Environment Canada approved the commercial production of genetically modified (GM, also called genetically engineered), Atlantic salmon in Canada. In November 2015 it was approved for human consumption in the United States and then in May 2016, it was approved for human consumption in Canada, making it the first genetically modified food animal approved anywhere in the world. The US company, AquaBounty (now a majority owned subsidiary of Intrexon), currently runs a facility in PEI where it has been producing GM salmon eggs for research. The company plans to produce GM salmon eggs in PEI and ship the eggs to Panama for commercial grow-out and processing, but Environment Canada’s approval also allows the company to grow out the fish in Canada. The company has also signaled its interest in expanding facilities to other countries and has started trials in Brazil and Argentina. The Atlantic salmon was genetically engineered with a growth hormone gene from Chinook salmon and genetic material from ocean pout (an eel-like fish), to grow faster than other farmed salmon. Canadian research indicates that GM salmon could out- compete wild Atlantic salmon for food and other resources. All regulatory decisions on genetically modified organisms in Canada are made without public consultation. Environmental Threats Genetic modification/engineering allows for the transfer of genetic material directly from one organism to another, across the species and kingdom barriers (for example from plant to animal) at the molecular level, and is dramatically different from traditional animal breeding. It can have unpredictable impacts on the organism and carries unknown risks for the ecosystem if the animal escapes into the wild. -
Tennessee's Governor
Tennessee Secretary of State Blue Book Lesson Plans Tennessee’s Governor Author: Lain Whitaker, St. Mary’s Episcopal School Grade Level: High School, U.S. Government and Civics Date Created: May 2015 (updated February 2016) John Sevier, TN State Library and Archives For additional lesson plans, click here. There are a limited number of hard copies of Blue Books available. To see about ordering a set for your classroom, please contact the Secretary of State’s office at (615) 741-2819 or one of your local legislators. The online version of the Blue Book is also available here. Introduction: The government of Tennessee, like that of the United States, is a republic. In a republic, people elect representatives to carry out their wishes. One of the most important officials Tennesseans elect is the governor, who is the head of the executive branch of state government. In this lesson, students will explore the role of the governor, the goals of a specific governor, how the governor reaches his goals, and the qualities governors need to be effective leaders. Guiding Questions: In what areas does Tennessee need to improve in order make the lives of its citizens better? What can one learn about a governor’s plans for his administration in the State of the State address the governor makes each year? What other individuals or groups must the governor work with to achieve his goals? Page 1 of 7 Learning Objectives: In the course of the lesson, students will… Develop an understanding of the role of the governor in Tennessee’s government. -
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INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. UMI University Microfilms International A Bell & Howell Information Com pany 300 North Zeeb Road. Ann Arbor. Ml 48106-1346 USA 313/761-4700 800/521-0600 Order Number 9325494 “War at every man’s door” : The struggle for East Tennessee, 1860—1869. (Volumes I and n) Fisher, Noel Charles, Ph.D. -
Where East Meets West in Water Law: the Formulation of an Interstate Compact to Address the Diverse Problems of the Red River Basin Marguerite Chapman
University of Tulsa College of Law TU Law Digital Commons Articles, Chapters in Books and Other Contributions to Scholarly Works 1985 Where East Meets West in Water Law: The Formulation of an Interstate Compact to Address the Diverse Problems of the Red River Basin Marguerite Chapman Follow this and additional works at: http://digitalcommons.law.utulsa.edu/fac_pub Part of the Water Law Commons Recommended Citation 38 Okla. L. Rev. 1 (1985). This Article is brought to you for free and open access by TU Law Digital Commons. It has been accepted for inclusion in Articles, Chapters in Books and Other Contributions to Scholarly Works by an authorized administrator of TU Law Digital Commons. For more information, please contact [email protected]. OKLAHOMA LAW REVIEW VOLUME 38 SPRING 1985 NUMBER 1 WHERE EAST MEETS WEST IN WATER LAW: THE FORMULATION OF AN INTERSTATE COMPACT TO ADDRESS THE DIVERSE PROBLEMS OF THE RED RIVER BASIN MARGuERITE ANN CHAPMAN* Introduction The completion of the Red River Compact in 1978 and its subsequent approval by Congress in 1980 was an important milestone both in the proper management of an increasingly precious natural resource and in the use of the interstate compact device to address the multifaceted problems of a re- gion such as the Red River basin. The overall objective of this article is to examine the formulation and approval of the Red River Compact in ad- dressing the diverse problems arising within the watershed of the Red River system. Part I assesses the divergent legal, environmental, and intergovernmental problems which shaped the compact.