STUDY on RISK ASSESSMENT: APPLICATION of ANNEX I of DECISION CP 9/13 to LIVING MODIFIED FISH Note by the Executive Secretary INTRODUCTION 1
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Salmon with a Side of Genetic Modification: the FDA's Approval of Aquadvantage Salmon and Why the Precautionary Principle Is E
Salmon with a Side of Genetic Modification: The FDA’s Approval of AquAdvantage Salmon and Why the Precautionary Principle is Essential for Biotechnology Regulation Kara M. Van Slyck* INTRODUCTION Over the last thirty years, once abundant wild salmon populations in the Pacific and Atlantic Oceans have declined to a mere fraction of their historic levels. As of 2016, salmon populations in Washington State’s Columbia River region are either failing to make any progress towards recovery or showing very little signs of improvement; Puget Sound salmon are only getting worse.1 In the Gulf of Maine, salmon populations dropped from five-hundred spawning adults in 1995 to less than fifty adults in 1999.2 Atlantic salmon, Salmo salar, were first designated as “endangered”3 in November 2000—the Fish and Wildlife Service (FWS) expanded the listing nine years later to include critical habitat along the coast of Maine as a result of little improvement to the population’s numbers.4 In the Pacific Ocean, FWS classified four significant salmon species as endangered for protection under the Endangered Species Act * Juris Doctor Candidate, Seattle University School of Law 2018. I would like to extend thanks to Professor Carmen G. Gonzalez for her valuable insight of the precautionary principle, her extensive knowledge on environmental regulations in the United States, and her unwavering support of this Note. 1. Governor’s Salmon Recovery Office, State of Salmon in Watersheds 2016, WASH. ST. RECREATION & CONSERVATION OFF., http://stateofsalmon.wa.gov/governors-report-2016/ [https:// perma.cc/6F3J-FKWE]. 2. Endangered and Threatened Species; Final Endangered Status for a Distinct Population Segment of Anadromous Atlantic Salmon (Salmo salar) in the Gulf of Maine, 50 C.F.R. -
Low-Temperature Tolerances of Tropical Fish with Potential Transgenic Applications In
Canadian Journal of Zoology Low -temperature tolerances of tropical fish with potential transgenic applications in relation to winter water temperatures in Canada Journal: Canadian Journal of Zoology Manuscript ID cjz-2017-0043.R1 Manuscript Type: Article Date Submitted by the Author: 13-Jul-2017 Complete List of Authors: Leggatt, Rosalind; Department of Fisheries and Oceans, CAER Dhillion, Rashpal;Draft University of British Columbia, Zoology; University of Wisconsin Madison, Wisconsin Institute for Discovery - Epigenetics Mimeault, Caroline; Department of Fisheries and Oceans, Aquaculture, Biotechnology and Aquatic Animal Health Branch Johnson, Neville; Department of Fisheries and Oceans, Aquaculture, Biotechnology and Aquatic Animal Health Branch Richards, Jeffrey; University of British Columbia, Department of Zoology Devlin, Robert; Fisheries and Oceans Canada, ANIMAL IMPACT < Discipline, COLD HARDINESS < Discipline, GENETIC Keyword: ENGINEERING < Discipline, TEMPERATURE < Discipline, FRESHWATER < Habitat, TEMPERATE < Habitat, FISH < Taxon https://mc06.manuscriptcentral.com/cjz-pubs Page 1 of 35 Canadian Journal of Zoology 1 1 Low-temperature tolerances of tropical fish with potential transgenic applications in 2 relation to winter water temperatures in Canada 3 R.A. Leggatt, R.S. Dhillon, C. Mimeault, N. Johnson, J.G. Richards, R.H. Devlin 4 5 Corresponding author: R.A. Leggatt: Centre for Aquaculture and the Environment, Centre for 6 Biotechnology and Regulatory Research, Fisheries and Oceans Canada, 4160 Marine 7 Drive, West Vancouver, BC, V7V 1N6, Canada, Email: [email protected], 8 Tel: +1-604-666-7909, Fax: +1-604-666-3474 9 R.S. Dhillon 1: Department of Zoology, University of British Columbia, 4200-6270 University 10 Blvd. Vancouver, BC, V6T 1Z4, Canada, [email protected] 11 C. -
Environmental Assessment for Aquadvantage ® Salmon
Environmental Assessment for AquAdvantage Salmon Environmental Assessment for AquAdvantage® Salmon An Atlantic salmon (Salmo salar L.) bearing a single copy of the stably integrated α-form of the opAFP-GHc2 gene construct at the α-locus in the EO-1α line Aqua Bounty Technologies, Inc. Submitted to the Center for Veterinary Medicine US Food and Drug Administration For Public Display August 25, 2010 Page 1 of 84 August 25, 2010 Environmental Assessment for AquAdvantage Salmon Table of Contents (Page 1 of 4) Title Page ............................................................................................................................. 1 Table of Contents ................................................................................................................. 2 List of Tables ....................................................................................................................... 6 List of Figures ...................................................................................................................... 6 List of Acronyms & Abbreviations ..................................................................................... 7 List of Definitions ................................................................................................................ 9 Summary ............................................................................................................................. 10 1.0 INTRODUCTION .................................................................................................. -
Fischen Entwickeln Und Bereits Relativ Weit Entwickelt Den Mutterleib Verlassen
Aulonocara Mix Malawi Kaiserbuntbarsch Systematik: Aquarium: Aquarium: ab 200 l PH: 7.5 - 8.5 GH: 5-20 °dGH Temperatur: 23 - 28 °C Über Aulonocara Mix: Endgröße: bis zu 12 cm Futter: Lebend-, Flocken- & Frostfutter Haltung: Harem Heimat: Malawisee Information: Aulonocaras stammen endemisch aus dem Malawisee. Die farbenprächtigen Buntbarsche ernähren sich in der Natur von Lebendfutter, nehmen im Aquarium aber schnell handelsübliches Futter, das aus Lebend- und Frostfutter, aber auch aus Flockenfutter und Sticks bestehen kann, an. Das Aquarium sollte Steinaufbauten, die Höhlen als Rückzugsgebiete anbieten und einen Sandboden aufweisen. Die Zucht im Aquarium ist einfach. Die Eier werden in einer Mulde im Sand abgelegt und dort befruchtet. Bei Aulonocaras handelt es sich um Maulbrüter, bei denen sich das Weibchen um die Aufzucht kümmert. Service-Info: Dieses Caresheet ist ein kostenloser Service von: Aquarienfreunde Bad Königshofen e.V. Am Kurzentrum 1 97631 Bad Königshofen Telefon: 0176 57 50 73 86 www.aquarienfreundebadkoenigshofen.de Diese Informationen dienen lediglich als Anhaltspunkte. Sie erheben keinen Anspruch auf Vollständigkeit oder Fehlerfreiheit und können keine Fachliteratur ersetzen. Informieren Sie sich zusätzlich z.B. durch ein Fachbuch. Bei Krankheitssymptomen nehmen Sie unbedingt Kontakt zu einem Tierarzt auf. Sollten Sie noch Fragen haben, helfen wir, das Team von Aquarienfreunde Bad Königshofen e.V., Ihnen gerne weiter. Aulonocara Mix (101082) - Caresheet erstellt durch www.hippocampus-bildarchiv.de Poecilia sphenops BLACK Spitzkopf-Molly Systematik: Aquarium: Aquarium: ab 80 l PH: 7.2 - 8.2 GH: 10 - 30 °dGH Temperatur: 22 - 28 °C Über Poecilia sphenops BLACK: Lebenserwartung: ca. 5 Jahre Endgröße: bis zu 10 cm Futter: Grün-, Lebend- & Flockenfutter, Algen Haltung: Gruppe Heimat: Südamerika, Mittelamerika Information: Poecilia sphenops gibt es in vielen Zuchtformen und kommt ursprünglich in Texas, Mexico bis Kolumbien vor. -
UNITED STATES SECURITIES and EXCHANGE COMMISSION Washington, D.C
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-36042 INTREXON CORPORATION (Exact name of registrant as specified in its charter) Virginia 26-0084895 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification Number) 20374 Seneca Meadows Parkway Germantown, Maryland 20876 (Address of principal executive offices) (Zip Code) Registrant's telephone number, including area code (301) 556-9900 Securities registered pursuant to Section 12(b) of the Act: Title of each class Name of each exchange on which registered Intrexon Corporation Common Stock, No Par Value Nasdaq Global Select Market Securities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes No Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes No Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. -
2019 World Congress Attendee List
2019 World Congress Attendee List Title COMPANY COUNTRY Global Marketing Director AB Enzymes Germany R&D Project Manager Acceligen - A Recombinetics Company United States CEO ACIES BIO Slovenia Head of Business ACIES BIO Slovenia Development Environmental Coordinator Adelante Consulting United States Project Manager Adelante Consulting United States Senior Vice President Advanatage Capital United States Chief Executive Officer Aequor, Inc. United States Chief Investment Officer Aether Earth Fund United States CEO Ag Ventures Alliance United States Chief Innovation Officer AgBiome United States Director, Microbials Agbiome, Inc United States Development Publisher/Editorial Director Agri Marketing Magazine United States Chercheur et chef d'Ãquipe Agrinova Canada Vice President Regulatory Agrisoma Biosciences, Inc United States Affairs Vice President, Business Agrisoma Biosciences, Inc Canada Development General Manager, North Ajinomoto Health & Nutrition North America United States American Research & Innovation Center Director, Forest Alberta Innovates - Bio Solutions Canada Technologies Manager, Clean Technology Alberta Innovates - Bio Solutions Canada Business Development Alderys France Director Head of Business Algenuity United Kingdom Development Senior Business Attraction Alliant Energy United States Manager Senior Economic Alliant Energy United States Development Manager Key Account Manager Alliant Energy United States CEO Altarum Institute France Research Chemical Amalgamated Research LLC United States Engineer Chemical Engineer -
Cambodian Journal of Natural History
Cambodian Journal of Natural History Artisanal Fisheries Tiger Beetles & Herpetofauna Coral Reefs & Seagrass Meadows June 2019 Vol. 2019 No. 1 Cambodian Journal of Natural History Editors Email: [email protected], [email protected] • Dr Neil M. Furey, Chief Editor, Fauna & Flora International, Cambodia. • Dr Jenny C. Daltry, Senior Conservation Biologist, Fauna & Flora International, UK. • Dr Nicholas J. Souter, Mekong Case Study Manager, Conservation International, Cambodia. • Dr Ith Saveng, Project Manager, University Capacity Building Project, Fauna & Flora International, Cambodia. International Editorial Board • Dr Alison Behie, Australia National University, • Dr Keo Omaliss, Forestry Administration, Cambodia. Australia. • Ms Meas Seanghun, Royal University of Phnom Penh, • Dr Stephen J. Browne, Fauna & Flora International, Cambodia. UK. • Dr Ou Chouly, Virginia Polytechnic Institute and State • Dr Chet Chealy, Royal University of Phnom Penh, University, USA. Cambodia. • Dr Nophea Sasaki, Asian Institute of Technology, • Mr Chhin Sophea, Ministry of Environment, Cambodia. Thailand. • Dr Martin Fisher, Editor of Oryx – The International • Dr Sok Serey, Royal University of Phnom Penh, Journal of Conservation, UK. Cambodia. • Dr Thomas N.E. Gray, Wildlife Alliance, Cambodia. • Dr Bryan L. Stuart, North Carolina Museum of Natural Sciences, USA. • Mr Khou Eang Hourt, National Authority for Preah Vihear, Cambodia. • Dr Sor Ratha, Ghent University, Belgium. Cover image: Chinese water dragon Physignathus cocincinus (© Jeremy Holden). The occurrence of this species and other herpetofauna in Phnom Kulen National Park is described in this issue by Geissler et al. (pages 40–63). News 1 News Save Cambodia’s Wildlife launches new project to New Master of Science in protect forest and biodiversity Sustainable Agriculture in Cambodia Agriculture forms the backbone of the Cambodian Between January 2019 and December 2022, Save Cambo- economy and is a priority sector in government policy. -
Genetically Engineered Fish: an Unnecessary Risk to the Environment, Public Health and Fishing Communities
Issue brief Genetically engineered fish: An unnecessary risk to the environment, public health and fishing communities On November 19, 2015, the U.S. Food & Drug Administration announced its approval of the “AquAdvantage Salmon,” an Atlantic salmon that has been genetically engineered to supposedly be faster-growing than other farmed salmon. This is the first-ever genetically engineered animal allowed to enter the food supply by any regulatory agency in the world. At least 35 other species of genetically engineered fish are currently under development, including trout, tilapia, striped bass, flounder and other salmon species — all modified with genes from a variety of organisms, including other fish, coral, mice, bacteria and even humans.1 The FDA’s decision on the AquAdvantage genetically engineered salmon sets a precedent and could open the floodgates for other genetically engineered fish and animals (including cows, pigs and chickens) to enter the U.S. market. Genetically engineered salmon approved by FDA Despite insufficient food safety or environmental studies, the FDA announced its approval of the AquAdvantage Salmon, a genetically engineered Atlantic salmon produced by AquaBounty Technologies. The company originally submitted its application to the FDA in 2001 and the FDA announced in the summer of 2010 it was considering approval of this genetically engineered fish — the first genetically engineered animal intended for human consumption. In December 2012, the FDA released its draft Environmental Assessment of this genetically engineered salmon, and approved it in November 2015. This approval was made despite the 1.8 million people who sent letters to FDA opposing approval of the so-called “frankenfish,” and the 75 percent of respondents to a New York Times poll who said they would not eat genetically engineered salmon.2 The FDA said it would probably not require labeling of the fish; however Alaska, a top wild salmon producer, requires labeling of genetically engineered salmon and momentum is growing for GMO labeling in a number of states across the U.S. -
Transgenic Fish Technology and Its Application in Aquaculture
* TRANSGENIC FISH TECHNOLOGY AND ITS APPLICATION IN AQUACULTURE Dr . G. B. CHAND Associate Professor Department of Zoology Aquatic Toxicology laboratory Patna University, Patna Email : [email protected] * Transgenic Fishes : Introduction . Organisms into which heterologous DNA (transgene) has been artificially introduced and integrated in their genomes are called transgenics. Genetically modified fish (GM fish) are organisms from the taxonomic clade which includes the classes Agnatha (jawless fish), Chondrichthyes (cartilaginous fish) and Osteichthyes (bony fish) whose genetic material (DNA) has been altered using genetic engineering techniques. In most cases, the aim is to introduce a new trait to the fish which does not occur naturally in the species, i.e. transgenesis. GM fish are used in scientific research and kept as pets. They are being developed as environmental pollutant sentinels and for use in aquaculture food production. In 2015, the Aqua-Advantage salmon was approved by the US Food and Drug Administration (FDA) for commercial production, sale and consumption, making it the first genetically modified animal to be approved for human consumption. Some GM fish that have been created have promoters driving an over-production of "all fish" growth hormone. This results in dramatic growth enhancement in several species, including salmonids, (Shao et al.,1992) carps (Robert et al.,2001) and Tilapias(Rahman et al.,2005; Hackett and Alvarez,2000). TRANSGENIC FISHES: INTRODUCTION . The first transgenic fish were produced in China in 1985( Dunham & Winn,2014). As of 2013, approximately 50 species of fish have been subject to genetic modification. This has resulted in more than 400 fish/trait combinations. Most of the modifications have been conducted on food species, such as Atlantic salmon (Salmo solar), tilapia (genus) and common carp (Cyprinus carpio).[Menozzi et al.,2013] What can transgenic technology offer? . -
Transgenic Animals
0( (-) 00 e_ ,Z5-1 Project Number: IQP — 43 — DSA — 9195 —5904 —0822 TRANSGENIC ANIMALS An Interactive Qualifying Project Report Submitted to the faculty of the WORCESTER POLYTECHNIC INSTITUTE In partial fulfillment of the requirements for the Degree of Bachelor of Science By Nicholas Far ey Scott LeBlanc Robert Redden Date: March 2, 2000 APPROVED: 1. transgenic 2. biotechnology 3. gene transfer Professor David S. Adams Project Advisor ABSTRACT This project investigated the use of transgenic animals in recent experiments and the effects of this novel technology on society. Using scientific journals and web resources, we examined the transgenic animals in existence, their uses, and the surrounding ethical and social issues. Recommendations were offered on which experiments involving transgenic animals should be continued and how to apply this new technology to the fields of science and medicine. ii TABLE OF CONTENTS SECTION PAGE Signature Page Abstract Table of Contents iii Executive Summary vii Project Objective xi List of Illustrations xii Introduction xiii 1. BACKGROUND AND HISTORY 1 1.1 Background Information 1 1.1.1 DNA 1 1.1.2 Replication and Expression 2 1.2 History of Transgenics 3 1.2.1 Prior to the First Transgenic Animal 3 1.2.2 The First Transgenic Animals 4 1.2.3 Further Experiments in the 1980's 5 1.2.4 Experiments Spanning into the Present 7 2. CURRENT METHODS 10 2.1 Superovulation 10 2.1.1 Choice of Parental Donor Strain 10 2.1.2 Hormone Cycle 11 2.1.3 Methods of Superovulation 13 iii 2.1.4 Flushing 14 2.2 Methods of Gene Transfer 17 2.2.1 Obtaining Recombinant DNA 17 2.2.2 Retroviral Vectors 19 2.2.3 Microinjection 20 2.2.4 Embryonic Stem Cells for Injections 22 2.2.5 Cultured Sperm Cells as Vectors 27 2.3 Transgenic Embryo Implantation 27 2.3.1 Embryo Inspection 27 2.3.2 Embryo Implantation Methods 28 2.3.3 Testing and Breeding 30 3. -
The Development of Genetically Modified (GM) Salmon in Canada
The Development of Genetically Modified (GM) Salmon in Canada In late 2013, Environment Canada approved the commercial production of genetically modified (GM, also called genetically engineered), Atlantic salmon in Canada. In November 2015 it was approved for human consumption in the United States and then in May 2016, it was approved for human consumption in Canada, making it the first genetically modified food animal approved anywhere in the world. The US company, AquaBounty (now a majority owned subsidiary of Intrexon), currently runs a facility in PEI where it has been producing GM salmon eggs for research. The company plans to produce GM salmon eggs in PEI and ship the eggs to Panama for commercial grow-out and processing, but Environment Canada’s approval also allows the company to grow out the fish in Canada. The company has also signaled its interest in expanding facilities to other countries and has started trials in Brazil and Argentina. The Atlantic salmon was genetically engineered with a growth hormone gene from Chinook salmon and genetic material from ocean pout (an eel-like fish), to grow faster than other farmed salmon. Canadian research indicates that GM salmon could out- compete wild Atlantic salmon for food and other resources. All regulatory decisions on genetically modified organisms in Canada are made without public consultation. Environmental Threats Genetic modification/engineering allows for the transfer of genetic material directly from one organism to another, across the species and kingdom barriers (for example from plant to animal) at the molecular level, and is dramatically different from traditional animal breeding. It can have unpredictable impacts on the organism and carries unknown risks for the ecosystem if the animal escapes into the wild. -
Problems in Gene Therapy and Transgenesis
Problems in Gene Therapy and Transgenesis Prof. Dr. Oliver Kayser Technische Biochemie TU Dortmund 16.03.2015 Chapter 5 - Transgenesis and Gene 1 Therapy Producing transgenic animals Purpose: Production of heterolog proteins in transgenic animals Principle: Integration of heterolog DNA with selected genetic information in fertilised eggs Methods: Mikroinjektion (-) Retrovirus vectors (-) Genetically modified embryonic stem cells (++) 16.03.2015 Chapter 5 - Transgenesis and Gene Therapy 2 16.03.2015 Chapter 5 - Transgenesis and Gene Therapy 3 Dolly 16.03.2015 Chapter 5 - Transgenesis and Gene 4 Therapy Telomers 16.03.2015 Chapter 5 - Transgenesis and Gene 5 Therapy klausurrelevant 16.03.2015 Chapter 5 - Transgenesis and Gene Therapy 6 16.03.2015 Chapter 5 - Transgenesis and Gene Therapy 7 Advantage of sheeps and goats as transgenic animals • high milk production capacity (2-3 l/ day) • short gestation period and quick maturation • low capital investment • easy handling and breeding • high expression level of proteins (35g protein/ l milk) • easy downstream processing • ongoing supply of product is guaranteed by breeding 16.03.2015 Chapter 5 - Transgenesis and Gene 8 Therapy Drug safety • Genetic stability from animal to anmial • Variation in produktion und purity during lactation • Microbial, varial, and mykoplasm contamination • TSE, Scrapie • Age and general conditions of animals 16.03.2015 Chapter 5 - Transgenesis and Gene 9 Therapy Atryn • First recombinant therapeutic protein approved in 2009 • Anticoagulant for treatment of antithrombin