Department of Anesthesia and Anesthesia Perioperative Care News

Spring 2016 | Vol. 15

Professor Lawrence Poree and Pain Medicine Fellow Lauren Friedman confer. Is This Neuromodulation’s Moment?

n the five years since a 2011 Institute of Medicine report revealed that 116 million Americans suffer from chronic, undertreated pain, clinicians have scrambled to Also in this issue: address their patients’ suffering. The increased attention on pain relief has come I even as physicians are increasingly reluctant to prescribe opioids due to headline ■■ Message from the Chair grabbing concerns about addiction. Those concerns have accelerated the search for ■■ Zuckerberg San Francisco General alternative treatments. Hospital and Trauma Center UCSF anesthesiologist Lawrence Poree, MD, PhD, would contend that for many ■■ Ask the Expert: types of pain, a viable alternative already exists in the form of neuromodulation, Mark Rollins, MD, PhD which encompasses a number of treatment modalities for neuropathic pain and other ■■ Critical Care Scholars Program Celebrates Successes conditions. Recently, Poree’s clinic in Aptos was one of 22 sites nationwide that tested a first of its kind device for dorsal root ganglion stimulation in cases of focal ■■ How Peripheral Nerve Injury Generates Chronic Neuropathic Pain pain. The study showed very positive results and the device recently received ■■ Anesthesia History FDA approval for the management of complex regional pain syndrome I and II of the lower extremities. ■■ The Ronald D. Miller Distinguished Professorship But neuromodulation has a long history of success and reaches well beyond focal pain, says Poree. Typically it involves implanting a device that either electronically ■■ Staff and Faculty Profiles stimulates nerves to modulate nervous system activity or serves as a drug delivery ■■ New Faculty system to infuse medications into the spinal canal. Poree adds that because ■■ Awards, Publications, Grants neuromodulation has become increasingly refined and precise, it is poised for ■■ Upcoming Events explosive growth. continued on page 4

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 1 Message from the Chair Inspired by Our History, Department Pursues New Pathways

he arrival of spring brings the promise of renewal. Our department has a long history of leadership in obstetric In addition to Easter and Passover, March marks anesthesia, and Mark Rollins, Chief of Obstetric Anesthesia at the annual ritual of the residency match. Starting in the the Betty Irene Moore Children’s Hospital describes changes in T fall, the residency office goes into high gear, receiving clinical practice that have led to improved maternal outcomes. applications, coordinating interviews, and ultimately developing The greatness of a department is determined by its people, the match list that is submitted to the and we are fortunate to have excellence across the board, National Residency Matching Program. from trainees, to staff, to our faculty and CRNAs. Faculty who We received over 800 applications and have worked at Moffitt-Long, Mt. Zion, or Mission Bay for the interviewed 150 individuals. On March last 10 years are aware of the extraordinary contributions of 18th, we learned the names of the 23 Judith Chan. Working with Dave Robinowitz, pediatric outstanding applicants that will be joining anesthesiologist and IT guru, Judith has the Herculean task of us for residency training on July 1, 2017. scheduling and organizing over 100 faculty, across multiple I’d like to salute the tireless efforts of sites, including managing bonus compensation. Judy’s Melissa Patrick, Kristina Sullivan, and calm demeanor and attention to detail are extraordinary, Manny Pardo, who lead the Education and I personally am so thankful for her professionalism and Office efforts, and especially Chief excellence. We couldn’t succeed without her and her team. We Residents Tina Dong and Jeremy Pearl, also highlight Christina Inglis-Arkell, who has led the transition who coordinate dinner with the of Mount Zion Hospital from a full-service cancer hospital to a applicants the night before the interviews, and serve as 23-hour stay ambulatory surgery center. Although only a few ambassadors for our program. In June, we will bid farewell to years out of training, Christy has built a high-efficiency many of our exceptional trainees, who will serve as envoys to operation with outstanding patient and staff satisfaction. academic and other programs, reminding them of the UCSF will host two important anesthesia meetings this extraordinary training provided by the department. spring. We are the host institution for the 54th Annual Western The use and abuse of opiates has become a public health Anesthesia Residents Conference (WARC). This meeting was crisis. While opiates serve many patients well, their efficacy started by Ted Eger, and has grown into a highly successful can be limited in patients with severe, chronic pain. In this event, with 300 residents from 19 western programs presenting issue, Lawrence Poree describes cutting-edge research and their work. In addition, in May, we will host the 63rd Annual clinical care in the emerging field of neruomodulation. Association of University Anesthesiologists meeting. In addition Lawrence is a nationally recognized figure in the field, and to the usual focus on research and education, UCSF will leads research and clinical trials focusing on this important present a host program with the theme of precision medicine, patient population. Neuromodulation is very much a featuring high-profile faculty from across the campus. multidisciplinary effort, with contributions from anesthesiology, As we forge new pathways in anesthesia clinical care, neurosurgery, neurology, psychology, and other disciplines. education, and research, we must stay grounded in our history. In our basic science research labs, studying the In this issue, Professor Merlin Larson discusses mechanisms of chronic pain constitutes a major effort by the Arthur E. Guedel Anesthesia Collection, recently department faculty. You will read how Zhonghui Guan has acquired by the UCSF Kalmanovitz Library. The collection published a seminal paper on how nerve injury can lead to includes anesthesia related artifacts that demonstrate essential chronic neuropathic pain. Our pain faculty are working in a contributions to the field, such as the development number of areas to both elucidate the mechanisms of chronic of muscle relaxants. A special thanks to Morgen Ahearn, pain and develop new treatments. department historian/archivist, Polina E. Ilieva, Head of UCSF Linda Liu describes our innovative Critical Care Scholars Archives and Special Collections, and David Uhlich, Assistant program. This is a unique program that recruits residents to a Archivist, UCSF Archives and Special Collections, for curating 5-year pathway that results in board certification in both the collection photos for the story. anesthesiology and critical care medicine. The program has Finally, we are delighted to announce the completion of been very successful, with all of our graduates transitioning fundraising of $2.5M to endow the Ronald D. Miller, MD, into both academic and private practice jobs combining Distinguished Professorship. This professorship will help anesthesiology and critical care medicine. support the recruitment of a world-class clinician-scientist and In May, the newly-built Zuckerberg San Francisco General mentor in the mold of Ronald D. Miller, MD. I would like to Hospital and Trauma Center will open. Jim Marks describes thank the numerous alumni and faculty that contributed to this this beautiful, state of the art hospital and trauma center, which successful effort. We will now begin the exciting task of will provide care to all San Franciscans, regardless of their recruiting an outstanding faculty member to fill the position. ability to pay. In future editions, we will describe the planning We look forward to your ongoing support of the department. for a dedicated research building, led by Sue Carlisle. Michael Gropper, MD, PhD Professor and Chair

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 2 The Heart of the City UCSF Department of Anesthesia Plays Key Role in Move to Zuckerberg San Francisco General Hospital and Trauma Center

he UCSF Department of Anesthesia and Perioperative Care has always had an essential role at Zuckerberg T San Francisco General Hospital and Trauma Center, which is the city’s safety net hospital, its busiest emergency room and its only Level One trauma center. Now, as clinicians and patients prepare to move into the newly named Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), the sense of excitement is palpable. The reasons include the $75 million donation from Facebook founder and CEO Mark Zuckerberg and his wife, UCSF pediatrician Priscilla Chan. “The Zuckerbergs’ commitment to support access to quality care for all, regard- less of ability to pay really helps elevate what we can do here,” says anesthesiologist Jim Marks, MD, PhD, who is the hospital’s chief of the medical staff. In that role – which he assumed in the summer of 2014 – Marks has been instrumental in shepherding a project that will come in on time and on budget. Since 2007, he also has been deeply involved in planning the new operating rooms and was a major contributor to the vision of placing all procedural services that require anesthesia or procedural sedation on one floor. “We will have a single intake point and recovery area, with the same standards and staff,” says Marks. “Many hospitals are coming to this type of approach, because it has a positive impact on both the quality and safety of care – and our staff and patients are going to be safer and more satisfied.” The emphasis on quality and safety will be a boon for people throughout San Francisco and speaks to what Zuckerberg himself emphasized at the new facility’s ribbon-cutting ceremony in November 2015. In describing the priorities he shares with his wife, Zuckerberg called SFGH, “…the heart of the city…. We support this hospital because we believe good health should not be out of anyone’s reach.” “We support this hospital because We will update you on this exciting move we believe good health should not after the new hospital opens in May 2016. n be out of anyone’s reach.” – Mark Zuckerberg

Top photo, from left: Jim Marks, MD, PhD; Mark Zuckerberg, Priscilla Chan, MD; Sue Carlisle, MD, PhD

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 3 Neuromodulation continued from front cover

Refinements Yield Results Poree began studying neuromodulation during his time as a PhD student at UC Berkeley and continued that work as a scientist at both Johns Hopkins and Stanford – all before he became a physician. After medical school, he completed a pain fellowship at UCSF and in addition to serving as a clinical professor in the UCSF Department of Anesthesia and Perioperative Care, is today treasurer of the North American Neuromodulation Society. He says that neuromodulation researchers and clinicians have begun to take advantage not just of new insights into how pain occurs, but also of advances that range from miniaturi- zation and enhanced computing power “Many patients don’t to better understanding of how to find someone who can neuromodulation, even as pain modify the levels and frequency of researchers are beginning to achieve neuromodulation “doses” in accordance provide this type of relief much deeper understanding about the with patients’ individual needs. All of nature of various types of pain. these advances have resulted in for many years and their Some of that work is happening at improved efficacy and fewer side effects. condition worsens with UCSF. Poree, for example, is engaged in “Two years ago, we talked about discussions with fellow pain physician 50 percent of people getting 50 percent the passage of time.” Zhonghui Guan, MD, (see accompanying benefit from neuromodulation, which is — Lawrence Poree, MD story) who recently published a study in fairly good, but there’s new technology Nature Neuroscience that identified a protein essential in activating every day and recent studies have shown who can provide this type of relief for neuropathic pain. The two hope their approximately 80 percent or more of many years and their condition worsens work can have some genuine synergy. people – both during the trial period with the passage of time,” he says. In addition, other major institutions and with the actual implants – got more He adds that if patients are treated have begun to show real interest in than 50 percent pain relief,” says Poree. early, neuromodulation is much more neuromodulation. The military, says He notes as well that the devices’ cost-effective than its upfront cost of Poree, has already begun using dorsal risk profile is similar to any invasive $30-50,000 for a full implant would root ganglion stimulation to treat procedure, and that there are few side cause people to believe. wounded soldiers experiencing effects, mostly paraesthesia. He says “When we’ve compared that to the neuropathic pain from what were those side effects will become even less cost of medications, addictions, repeat originally peripheral injuries. Many of common with the newer technologies spine surgery and physical therapy over these soldiers, says Poree, were able to that enable more precise targeting of the course of two years, neuromodu- return to regular activity without any problem areas. lation is actually cheaper in many cases,” need for pain medications. The military’s he says. “Our dorsal root ganglion study, Proving the Efficacy, work in this area will be a major focus of for example, looked at treating complex Cost-Effectiveness the 2017 North American regional pain syndrome using In Poree’s own clinical work he says, Neuromodulation Society Scientific neuromodulation and the cost was “We can treat a broad spectrum of Meeting, which Poree will co-chair. equivalent over roughly two to two and a neuropathic pain using neuromodulation He believes that as these factors half years.” He adds the Medicare has techniques.” converge, the advances will begin to been covering neuromodulation for He also believes we are not using accelerate, especially in concert with decades and many private insurers cover neuromodulation to its fullest potential President Obama’s BRAIN initiative, it as well, though often not with a great and turning to it far too late in the announced in 2013. deal of enthusiasm. paradigm of pain treatment. “Soon,” says Poree, “We’ll be talking “It’s a travesty to wait for patients to Excitement is Building about individual neural stimulation with meet the definition of chronic pain,” he Poree believes, however, that a the goal of having clinical control over says. “Many patients don’t find someone confluence of recent studies is the most sophisticated electrical network generating real excitement about imaginable.” n

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 4 Ask the Expert: Mark Rollins, MD, PhD What Changes in Clinical Practice Could Improve Obstetric Care? here are always things we can do to improve obstetric (OB care), but over the last few years one T important focus has been reducing maternal mortality. From the 1930’s through the 1980’s the rate of maternal death in the United States decreased substantially from approximately 1 in 100 and did not have access to all possible California hospitals with implementation. to about 1 in 8,000. Yet over the last treatment methods. Since its creation, more than 100 decade, data emerged revealing that the In response, the CMQCC devised a California hospitals – which provide United States not only had the highest toolkit for hospital teams aimed at services for an estimated 230,000 births mortality rate of any high resource addressing PPH and went about per year – have implemented the toolkit. country, but also was the only developed disseminating it in partnership with the Though we can’t prove causality, it’s country to have had an increase in California Partnership for Maternal Safety. striking that since 2008 California’s maternal mortality since 1990 – and that The primary goals were for all participa- maternal mortality rate is significantly the rise was not explained by increases ting hospitals to develop and implement reduced when compared with the rest of in risk factors. a multidisciplinary team response, with the United States. We were the only state In the mid 2000s, California, the expectation that this could reduce using the toolkit during much of this time. physicians and other health care leaders major complications associated with The disparity is even greater when you began to examine how we deliver OB massive hemorrhage by 75 percent. understand that California’s birth rate is care and how to improve that care, which The toolkit is extensive but, in brief, about 1/7 of the entire United States. led to the formation of the California it contains a set of best practices for The toolkit is now getting much wider Maternal Quality Care Collaborative addressing PPH, a checklist for exposure in other parts of the country (CMQCC) in 2006. In the wake of a major managing the condition and other tools and around the world, and it has led to study that found of 8.5 million hospital that range from sample policies and the development of another organization deliveries in the US from 1999 to 2008, procedures to charting examples and focused on maternal safety the rate of severe postpartum implementation hints. (safehealthcareforeverywoman.org). hemorrhage (PPH) had more than To help ensure success, the toolkit Moreover, the success we’ve had with doubled, the CMQCC created an effort had elements that each hospital could PPH has led the CMQCC to begin to to reduce the incidence of PPH. Elliot modify slightly to its unique logistics and extend its focus to other factors Main, MD, led this statewide effort with clinical needs and the CMQCC’s associated with maternal mortality during Mark Rosen, MD, UCSF director of OB multidisciplinary expert panel assisted childbirth, including pre-eclampsia and Anesthesia at the time and involved from clinical leaders from numerous pulmonary embolism. n the outset, along with Audrey Lyndon from UCSF School of Nursing. In 2009, I joined the effort as part of a multi- The toolkit addresses four key areas: disciplinary expert panel, whose charge ■■ Readiness: How to assess patient risk levels, train and drill staff and have was to work with hospitals throughout the necessary supplies readily available, including a hemorrhage cart the state to incorporate the CMQCC and medications recommendations into clinical practice. The effort began with a survey of ■■ Recognition: Guidance and best practices for assessing and documenting California hospitals on their PPH clinical blood loss, such as using under-buttock drapes with graduated markers practices. That survey found, among during vaginal birth for early recognition of hemorrhage other things, that 40 percent of hospitals ■■ Response: Checklists and procedures for addressing hemorrhage with in the state did not have a hemorrhage stepped, evidence-based interventions protocol, used inconsistent definitions ■■ Reporting: How to assess hemorrhage-related quality improvement measures, of hemorrhage, were not regularly including establishing a culture of huddles and post-event debriefings for participating in drills for the condition high-risk patients

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 5 Education Critical Care Scholars Program Celebrates Successes

“ he vision was for an innovative “One of the common stories is that Rising to Challenges track that would attract we were all interested in critical care, even Donovan says that by year four, the residents interested in critical before anesthesia,” says Anne Donovan, critical care scholars already are more T care by blending the anesthesia MD, who was part of the first official class senior residents and that attendings residency and critical care fellowship,” to complete the program and is now a value the scholars because of the says Linda Liu, MD, who directs the member of the Department’s faculty. experience they’ve already attained. Critical Care Scholars program in the “And as we work to make this not just a “Residents who do this track are UCSF Department of Anesthesia and track, but a community, we’re looking for asked to do advanced clinical situations Perioperative Care. that same type of thought process when earlier in their training process – with a In contrast with the more traditional trying to pick new members.” lot of peer mentorship at transition points route of four years of residency and a “I think because we all start out as and I feel like I’ve been well prepared to one-year fellowship, the program like-minded people with similar goals, we be a good fellow,” says Chang. integrates the anesthesia residency quickly get to know each other well and “It definitely made me a better and critical care fellowship across the feel comfortable going to each other resident and as I transitioned to ICU entire five years. Scholars are exposed with personal or professional concerns,” fellow and then back to the OR, I noticed to more critical care situations than is says Lindsey Huddleston, MD, who was a huge difference in myself, especially in typical in years one through three and in the second graduating group and my comfort in working independently then move back and forth between their also has joined the department’s faculty. and in thinking more globally about the fellowship and their anesthesia residency Those who are in the midst of the patients’ entire perioperative course,” in years four and five. program agree. “Early in residency, says Huddleston. “In the OR we get Liu says, “By tying people into their you can always turn to people who comfortable taking care of all of a fellowship early, we hoped it would help were above you in the program to ask patient’s needs – managing hemo- them better meet the needs of critically ill questions… in the ICU, or just about dynamics, the ventilator, continuously patients and encourage them to remain getting through residency and how to assessing how the drugs we’re in academic medicine.” navigate the UCSF system,” says administering change physiology. That By both of these measures, the Thomas (TJ) Krall, MD, who is in his translates when we get to the ICU, where program’s early years – it enrolled its first fourth year of residency, where the we may be more comfortable with two participants in 2009 and accepts scholars begin to toggle back and forth ordering certain things at the bedside. up to two participants each year – have between their critical care fellowship And when you flip it and you’ve taken been an unqualified success. All of the and their anesthesia residency. care of very sick patients in the ICU, it program’s first five graduates have taken “I tend to text [the other scholars]… increases your comfort level taking care faculty positions in critical care, four of because I’m so comfortable with them. of a very sick patient in the OR.” them at UCSF. I interviewed at other places and this “The program has really evolved,” place was just more personable,” says says Liu. “The original notion was to turn Informal Mentoring Leads to Joyce Chang, MD, who is in year five. a Genuine Community out critical care intensivists, but thanks to the quality of our department and the Participants say the successes of the sense of community, most of our program are attributable to a number of scholars have stayed on here as faculty factors: the quality and reputation of the who have a real respect for each other department and its leadership in critical both personally and professionally.” n care medicine; exposure to challenging cases; the faculty’s willingness to attend to the scholars’ interest in critical care from day one, and; the creation Below, Assistant Professor Anne Donovan of a supportive, informal mentoring leads critical care medicine rounds. community among the critical care scholars themselves. Professor Linda Liu, The last was an unplanned, though Critical Care Medicine not unexpected outgrowth of a program Track Scholar Matthew that draws people with similar interests Dudley, and Assistant Professor Andrew and temperaments. Schober, in the ML ICU

“The program has really evolved...most of our scholars have stayed on here as faculty.” – Linda Liu, MD

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 6 Faculty Profile

where they take advantage of the area’s events so she can consistently refine Inglis-Arkell Plays physical beauty and opportunities for patient selection criteria and make outdoor activities. improvements to patient care. Essential Role Still, part of her heart remains in Another focus for Inglis-Arkell has San Francisco, particularly at Mount been maintaining a smooth flow from in Mount Zion Zion where she has developed strong preoperative care through post-acute relationships with her colleagues. That’s care units. “It’s important for us to Transformation been important as Inglis-Arkell has function efficiently if we’re to make sure thrown herself into formulating new each of our patients has a safe, high n February 2015, anesthesiologist patient criteria and assessing staffing quality experience,” she says. Christina Inglis-Arkell, MD, assumed and facility needs to accommodate a the positions of anesthesia director broad range of patients for ambulatory A Supportive Environment I and medical director of the surgery surgeries and 23-hour stays. Though not without bumps, Inglis-Arkell center at UCSF’s Mount Zion campus. “The 23-hour rule expands the says the transition process has been Both roles have been important, as number of surgeries we can perform relatively smooth and the facility has Mount Zion has transformed itself into here, but it also creates challenges increased its volumes while also seeing a facility focused on ambulatory care because we need to be able to monitor increases in surveyed patients’ and 23-hour stays in the wake of many and respond to patients overnight, satisfaction scores. Achieving those aims services moving to the Mission Bay who have some slightly more complex has demanded not just research campus when it opened a year ago. issues,” says Inglis-Arkell. For example, on similar centers around the country And both roles present a challenge for initially sleep apnea patients were not but, especially, close collaboration someone who was just three years appropriate, but after Inglis-Arkell among current faculty and staff. removed from her physician training. ensured appropriate equipment “One of the reasons Mount Zion “Though I had some leadership availability and respiratory therapy works very well is that it’s a really great, experience at Mount Zion and learned staffing, she was able to expand the collaborative environment with a small a lot by working under Spencer Yost criteria to include sleep apnea patients. hospital feel,” she says. “There’s there, the chair showed a lot of faith Nevertheless, she says, because outstanding communication and in me by offering me this position,” patient selection remains an ongoing teamwork among the nurses, surgeons says Inglis-Arkell. challenge, it’s important to carefully and anesthesiologists, which enables A Commitment to Mount Zion track morbidity, mortality and adverse us to accomplish a lot.” n At the start of her residency, Inglis-Arkell moved to the Bay Area from southern California, because UCSF has “the best “One of the reasons Mount Zion works very well is that anesthesia program in country” – and because her husband is from the area. it’s a really great, collaborative environment with a After the birth of her second child, she small hospital feel.” – Christina Inglis-Arkell, MD and her family moved to Mill Valley,

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 7 Research How Peripheral Nerve Injury Generates Chronic Neuropathic Pain Anesthesiologist and pain specialist Zhonghui Guan, MD, recently published a paper in Nature Neuroscience that opened a new window of understanding on how peripheral nerve injuries lead to chronic neuropathic pain. Guan, who studies the mechanisms of pain in the lab of Allan Basbaum, PhD, has filed a patent based on the findings.

What and How the “Today, our attempts to treat neuropathic pain often fail because Discovery Was Made we’ve known so little about the cellular and molecular Specifically, Guan’s studies found that mechanisms that cause it. That’s why I believe this discovery after peripheral nerve injury, the injured sensory neurons in dorsal root ganglion has significant clinical relevance.” – Zhonghui Guan, MD (DRG) express a chemokine called colony-stimulating factor 1 (CSF1) and and that this neuro-inflammation is the we have the tools now to deliver it send it to the spinal cord to activate direct consequence of an injury to the right to the target. And we not only microglia through the CSF1 receptor peripheral nerve, even though the injury discovered CSF1’s role, but also found (CSF1R), which is expressed only in site is anatomically far away from the that it was activated on day one, so microglia in the spinal cord. Microglia, spinal cord,” says Guan. perhaps rather than wait three months the tissue macrophages in the central [as is typically done now], we can nervous system (CNS), are the only Accelerating the Race address the pain when it is acute and immune cells in CNS and are implicated for Better Treatments head off the chronic phase.” in nearly all neurological diseases. Since the Institute of Medicine issued Thus, one key next step for Guan Prior to Guan’s work, we knew that a report in 2011 that found some is to develop a version of an already injured neurons activate microglia, 116 million Americans live with untreated existing antibody that physicians can but we didn’t know how. Guan’s team chronic pain, clinicians have sought deliver epidurally or intrathecally near set about answering this question by ways to ease their patients’ suffering. the spinal cord. severing a peripheral sensory nerve in To date, however, progress has been “Another potential approach is to mice, testing whether the injury disappointing. block the induction of CSF1 if we can generated chronic neuropathic pain “Chronic neuropathic pain treat- identify the signal. In that case, maybe and using RNA sequencing to discover ments are still very poor,” says Guan. one treatment can solve the problem,” the increased expression of CSF1 in “The medications we use are only says Guan. DRG and CSF1R in the spinal cord. about 30 percent effective in 30 percent While the current focus of this The researchers then removed the of patients.” research is on peripheral nerve injuries CSF1 gene from the DRG and found that He says in cases of neuro-inflam- that lead to chronic neuropathic pain, this stopped the activation of microglia mation, typically the most effective the involvement of microglia and the and eliminated the chronic pain. option is to flood the area with steroids, discovery of CSF1’s role imply that, Conversely, injecting CSF1 intrathecally such as epidural steroid injection, ultimately, the findings could lead to into the mice – without injuring the but it’s not clear why these treatments treatments for many other neuropathic peripheral nerves – resulted in both succeed and they have to be used with pain conditions. microglial activation and chronic pain. real caution. “We are very excited to move “Our work clearly shows that Guan believes his findings might ahead to the next phase of this work,” neuro-inflammation in the spinal cord offer a much better option, because, says Guan. n occurs when there is neuropathic pain, “If we can find the right medication,

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 8 Staff Profile Nothing Less Than Success: The Essential Role of Judith Chan

“ or any large project or enterprise Getting People Paid Properly system to a more standardized system activity to be successful, On the payment side, Chan ensures from a third party vendor. somebody needs to take quarterly pay and per diem payments are “It’s important that we take advantage F ownership, someone committed to of technology advances, but it won’t be accurate while processing administrative success who will stay until the work is payments such as housing allowances easy,” says Robinowitz. done,” says anesthesiologist David and special research study payments. “There are so many new rules,” says Robinowitz, MD, of Judith Chan, clinical “The hardest part is making sure that Chan. “Not only is this a new system, but manager for the UCSF Department of the clinical data is reflected accurately,” numerous changes happen every quarter Anesthesia and Perioperative Care. she says. on the basis of compensation committee “Judy has that role as regards scheduling “Judy has to look at and validate changes that Judy and Adam [Jacobson, and compensation for our department.” the data, which isn’t easy since director of IT] have to operationalize,” After originally joining the department information that comes out of APeX says Robinowitz. “They have to take as a temporary employee, Chan (UCSF’s electronic medical record) can these concepts and figure out how to assumed a full-time position in April have documentation mistakes and there make them happen in the hard and fast 2005, eventually transitioning into her can be different rates during different rules of a computer system.” current role where she works closely periods of the day,” says Robinowitz. “We need to get staff fully trained and with the scheduling team, human “We do tens of thousands of cases a up to speed by the end of December,” resources, E1s, service chiefs, the IT year and yet she makes sure everyone says Chan. group and department leadership. gets the pay due them.” Robinowitz is confident that she will As the department transitions to a be a crucial cog in ensuring it all gets new software system for scheduling Implementing a New System done and done well. “She is very results- and compensation, her role has only Even as she wrestles with her complex oriented and takes ownership of making increased in importance. everyday challenges, Chan must now sure things work and doesn’t accept anything less than success,” he says. n Managing Puzzle-Like be among those leading the implemen- tation of a new scheduling platform – Scheduling Demands a transition from a largely homegrown “Scheduling is a giant puzzle that affects peoples’ lives every day,” says Chan. “I like the ongoing challenge of trying to accommodate people’s needs while still keeping our calendar full… there’s always something new to learn.” She says working with clinical leadership, a chair and a compensation committee she likes and respects eases the challenges of coping with faculty departures, leaves, vacations, diverse locations, increased workloads – and the fact that few days are the same. On Mondays, for example, “Things often happen over the weekend that result in staffing variances, so we have to start talking to team members and E1s to figure out what work needs to be Thank you Judy accomplished,” says Chan. “We then need to call faculty and CRNAs to start filling empty slots, but they are really supportive of each other and committed to helping out when there is a need.” “Judy is the last line of defense – she’s the one who makes sure there’s an appropriate person for every assignment every day,” says Robinowitz.

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 9 Arthur E. Guedel Memorial Anesthesia Center Finding Insight and Inspiration in Anesthesia History

hen the UCSF library held its monthly history lecture in December 2015, those who attended likely got more than they bargained for. The lecture – The W Transformation of Anesthesia, 1900-1960 – was a combination of riveting storytelling, revelations about the treasure trove of anesthesia history now housed at UCSF and a powerful argument for history’s relevance. Discovery Stories Faculty emeritus John Severinghaus, MD, and faculty member Merlin Larson, MD, were the evening’s storytellers. Severinghaus told of the remarkably productive correspondence in the 1930s and 1940s between UCSF pharma-cologist Chauncey Leake, PhD – who spent much of his career investigating anesthetic agents – and anesthesiologist Arthur Guedel, MD, who is credited with perfecting the endotracheal tube among other anesthesia- related discoveries. Their collaboration was the inspiration for what is now the Arthur E. Guedel Memorial Anesthesia Center, which after many years at California Pacific Medical Center was recently moved to the Kalmanovitz Library on UCSF’s Parnassus campus. The Center, says Larson, houses an extensive collection of historical materials on anesthesia – and, likely, the most extensive documentation of West Coast contributions. Larson’s talk centered on an adventurer named Richard Gill, who in the 1930s wound up working for a rubber company in Lima, Peru. After buying land on the eastern slope of the Andes, Gill and his wife immersed themselves in what Larson calls “the jungle pharmacy…where he learned how to make curare in the hope – at first – that it would help alleviate his own painful muscle spasms, which he developed after falling from his horse.” The treatment for muscle spasms never worked out, but Gill came to believe that curare might be used as an effective muscle relaxant for a variety of ailments. He spent years earning the trust of local Indians, which eventually enabled him to return to the U.S. with 25 pounds of curare paste. After his return in 1938, he found no takers, except a psychiatrist, who thought he might be able use the curare to prevent bone Eventually this fractures, which often followed convulsive therapy for schizophrenia. arrow poison Eventually, however, word of curare’s properties reached of the Jivaro Stuart Cullen, MD, before he arrived at UCSF as the first chair for the Department of Anesthesia. Cullen quickly understood Indians evolved that drugs like curare might be an effective way to provide into the modern muscle relaxation during abdominal surgery. “Curare was originally used as a very crude preparation muscle relaxants called Intocostrin, but chemists learned rapidly to purify the that we use today. drug and study its structural formula. Eventually this arrow poison of the Jivaro Indians evolved into the modern muscle relaxants that we use today. The development of paralyzing agents (muscle relaxants) used in anesthesia provides us continued on next page

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 10 Arthur E. Guedel Memorial Anesthesia Center continued with a microscopic view of how advances happen in clinical science,” says Larson. “Each step along the way, someone had an ill-conceived idea and the next person improved on it until we got it right. That’s important, because at any research institution, we have to do original research and so [at the very least] history helps us avoid repetition and mistakes.” That belief drives Larson’s dedication to preserving his profession’s history, especially through the Guedel Center, which among other things has a large collection of Leake’s papers and books (including his correspondence with Guedel), a copy of Humphrey Davy’s 1800 book which describes the analgesic properties of nitrous oxide, multiple photographs and films and Guedel’s original tracheal tubes and cuffs. Exploring New Ways to Remind People of History’s Relevance Merlin Larson and Selma Calmes signing the agreement to transfer the Arthur E. Guedel Anesthesia Collection to the UCSF “It was Leake’s idea [upon Guedel’s death in 1956] to create a Archives & Special Collections, March 2015. museum, one that highlights ideas and inventions that really advanced anesthesia,” says Larson, who finds their correspondence particularly moving, because it reveals such things as how a physician’s emotional pain over losing patients can drive discovery – and how physicians’ expertise and experience does, indeed save lives. “The material also demonstrates the essential contribu- tions of other West Coast anesthesiologists, including Severinghaus, [Edmund] Eger and [Sol] Shnider who all grew out of this department; modern anesthesia really started here,” says Larson. Yet he’s also aware that history can be a hard sell to this generation of physicians who often emerge from training deeply in debt and desperate to find a job. History can be the last thing on their minds, but Larson believes this only makes it more important. “They have a 30-year career ahead of them and knowing at least a little bit [of history] enhances their professional life,” says Larson. These materials, he insists, articulate important issues that still challenge anesthesiologists today, whether it’s how to integrate into a hospital system or how to cope with those times when physicians cannot save or help their patients. With that in mind, the Guedel Center is intent on finding new ways for the next generation of physicians to access the materials – perhaps a virtual library, digital displays or other uses of modern technology. “As a practitioner, you might find someone in history you admired and decide you want to live that type of life,” says Larson. “History has that ability, to not just inform but inspire.” n

“Each step along the way, someone had an ill-conceived idea and the next person improved on it until we got it right.” – Merlin Larson

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 11 Ronald D. Miller Distinguished Professorship Preserving a Historic Legacy

Late in 2015, the UCSF Department of Anesthesia and Perioperative Care successfully completed fundraising to establish the $2.5 million Ronald D. Miller Distinguished Professorship of Anesthesia and Perioperative Care. In the piece below, Dr. Miller responds to the generosity of his colleagues and alumni – and speaks about his hopes for this position.

was pleased and honored that so this professorship will fund a leading many people were so generous – clinical investigator to guide and even and extremely gratified that we will lead our department in stimulating and Ibe able to use this Professorship to training residents who want to pursue perpetuate an important component of clinical research as a career goal. our department’s legacy. That’s what’s When I arrived at UCSF as a first-year important here. This professorship resident in 1965, I knew nothing about is not so much about me as it is about research. Then, for the first time, I saw ensuring that the components and anesthesia personnel performing studies approaches that made this depart- in the operating room. After attending ment great, even historic, can live on some faculty presentations regarding and inspire the next generation of clinical research, I began to realize there anesthesia leaders. was a world out there I wanted to join. In particular, I hope the professorship And even though I was just an average can help us maintain two simple student in medical school, I was able to attributes. The first is the opportunity to perform clinical research for a year under be surrounded by very smart people. It’s careful faculty guidance from our fun and productive to be around people department, the Cardiovascular who inspire you and that’s the main Research Institute, and the Department reason I’ve stayed at UCSF for such a of Pharmacology. The research was “I hope the professorship long time. My chances of being around published and even won first prize in the can help us maintain two smart people, including those from other 1968 ASA Resident’s Essay Contest. departments, were greater here than any That training also provided me with the simple attributes. The first place I’ve ever been. proficiency to successfully perform The second attribute – and this is clinical research with massive blood is the opportunity to be what I think the professorship can play a transfusions in Vietnam. The results of surrounded by very smart crucial role in sustaining – is the my research in Da Nang during the opportunity to perform groundbreaking Vietnam conflict were a major reason I people.... The second is the clinical research. One might easily focus was subsequently elected into the opportunity to perform on basic science research as UCSF’s Institute of Medicine. Without the training calling card – think of our Nobel Prize in clinical research I received at UCSF, groundbreaking clinical winners – but in my mind, clinical my research would not have occurred. research.” research is equally important. It is a – Ronald D. Miller major reason this department has The Value of Hands-On flourished since its inception. Clinical Research The challenge, I believe, is that clinical My approach to research is different research has become increasingly from today’s basic research or computer- difficult to perform and fund. This based clinical research. Both of those challenge steadily progressed during are important and can improve clinical the 25 years I was chairman and has care. Yet neither replaces the valuable continued since then. There are information gleaned from original data several factors, most notably increased collected from patients undergoing regulatory oversight and reduced clinical anesthesia care in the funding. Yet surrendering to those perioperative period. Furthermore, the obstacles cannot be an option. My respect, cooperation and working hope, in my advancing years, is that relationships that evolve from hands-on

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UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 12 Ronald D. Miller Distinguished Professorship continued

“I hope the professorship will foster the type of excitement and collaboration that make this work so rewarding and such a tremendous inspiration for excellence in anesthesia care.” – Ronald D. Miller clinical research are very valuable in the UCSF School of Pharmacy where The result was not only that we many ways. people told me the compounds we were improved patient care, but also that One example: In one of my early using had metabolites and that they many people from different disciplines studies, I was trying to determine the could develop an assay to detect these worked together to complete those extent to which neuromuscular blocking pharmacologically active metabolites. studies, which created an inter- drugs (i.e., muscle relaxants) were This even resulted in a New England departmental atmosphere of intellectual dependent on renal exertion for their Journal of Medicine publication. cooperation that was rewarding to elimination. I needed the cooperation of Equally important, these studies everyone involved. kidney transplant surgeons as we facilitated cooperation among surgeons, Unfortunately, as noted above this developed a protocol and an assay that operating room, and intensive care type of innovative clinical research is could measure these drugs in plasma physicians. We all could see that increasingly difficult to perform and and urine. I also needed help from changing the muscle relaxant regimen fund – despite being vitally important. pharmacologists to create the assays. was better for patient care and our Thus, I hope this distinguished In addition, William K. Hamilton, the chair colleagues encouraged us to do more. professorship will facilitate the survival of our department at the time, sent me Often, when we did those types of and growth of meaningful, prospective to London to attend a muscle relaxant studies, they would have outcomes we clinical research. Companion to that, meeting – my first time east of New York. didn’t anticipate, leading to two or three I hope the professorship will foster the That led to a sabbatical in Holland where additional questions. But in all of these type of excitement and collaboration pilot studies were performed with a new cases, the studies depended in part on that make this work so rewarding and drug called vecuronium. We published a physicians’ clinical judgment and such a tremendous inspiration for few papers and I started presenting at observation to generate important, excellence in anesthesia care.n relevant inquiries.

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 13 Honors, Awards & Appointments New Faculty

Arun Prakash, MD, PhD Odinakachukwu Ehie, MD Faculty EXTRAMURAL APPOINTMENT Health Sciences Associate Member, Association Assistant Clinical Professor Pedro Gambus, MD, PhD of University Anesthesiologists, Joined Faculty February 2016 EXTRAMURAL APPOINTMENT Member, Association of University 2015 MEDICAL SCHOOL Anesthesiologists, 2015 University of Wisconsin Oliver Radke, MD, PhD School of Medicine and Public Health EXTRAMURAL APPOINTMENTS Michael Gropper, MD, PhD INTERNSHIP Local Residency Director, Medical EXTRAMURAL APPOINTMENTS Internal Medicine, Board of Bremen, Germany, 2016 President, Western Association SUNY Downstate Medical Center Member, Scientific Sub-Committee of Anesthesia Chairs RESIDENCY VISITING PROFESSORSHIPS “Outpatient Anesthesia,” German Society of Anesthesia and Anesthesiology, Department of Anesthesia New York University Langone Medical Center and Perioperative Medicine, Intensive Care Medicine, 2016 FELLOWSHIPS Rutgers University, 2015 Mark Rollins, MD, PhD Pediatric Anesthesia Department of Anesthesia, EXTRAMURAL APPOINTMENT Stanford University / University of Colorado, Member, Association of University Lucile Packard Children’s Hospital Denver, 2015 Anesthesiologists, 2015 PREVIOUS EMPLOYMENT Department of Anesthesia, Clinical Instructor, Stanford University / Duke University School of Jeffrey Sall, MD, PhD Lucile Packard Children’s Hospital Medicine, 2015 EXTRAMURAL HONOR EXTRAMURAL HONORS Faculty Mentor: UCSF Medical Mark Singleton, MD FAER-Helrich Research Lecture Student Anesthesia Interest Group Keynote Speaker, Anesthesiology Health Sciences Clinical Professor American Society of Joined Faculty October 2015 and Critical Care Medicine Anesthesiologists MEDICAL SCHOOL Symposium of West China, Best Anesthesia Interest Group UCSF Chengdu, China in the US, 2015 Hermann B. Stein Lectureship, INTERNSHIP University of Colorado Charlene Swift, MD, PhD Surgery, University Hospital, Ann Arbor, Michigan CAMPUS APPOINTMENT RESIDENCY Tomoki Hashimoto, MD UCSF School of Medicine Anesthesiology, UCSF EXTRAMURAL APPOINTMENT John A. Watson Scholar, 2015 Association of University FELLOWSHIPS Anesthesiologists Scientific Kevin Thornton, MD Clinical Anesthesiology, Children’s Hospital of Philadelphia Advisory Board, 2016 EXTRAMURAL APPOINTMENT Member, Association of University Pediatric Anesthesiology Research, UCSF Irfan Kathiriya, MD, PhD Anesthesiologists, 2015 PREVIOUS EMPLOYMENT EXTRAMURAL AWARD Clinical Professor of Anesthesiology, Society for Pediatric Anesthesia Stanford University School of Medicine Inaugural Young Investigator Staff Research Grant “Mechanisms for Melissa Patrick, MBA Visiting Faculty Ventricular Septation” EXTRAMURAL HONOR Mentor: Benoit Bruneau, PhD Poster Presentation, “The Impact of Implementing an Additional Dieter Adelmann, MD, PhD Michael Lipnick, MD Verbal and Written Feedback Visiting Clinical Instructor CAMPUS AWARD System for Anesthesia Residents,” UCSF Academic Senate, 2016 accepted for California’s Macy Joined Faculty October 2015 Development and Support of a Regional Conference on ADVANCED DEGREE Global Health Faculty Program Innovations in GME, 2016 PhD, Clinical Neurosciences Medical University of Vienna, Austria Jennifer Lucero, MD MEDICAL SCHOOL CAMPUS APPOINTMENT Medical University of Vienna, Austria Director, Undergraduate Department Research Internship (URI) – INTERNSHIP UCSF Department of Internal Medicine, HELIOS Hospital Berlin-Buch, Anesthesia, 2016 Anesthesia and Perioperative Berlin, Germany Care Medical Student Ronald D. Miller, MD RESIDENCY Anesthesia Interest Group CAMPUS HONOR Anesthesiology and Intensive Care, EXTRAMURAL HONOR Ronald D. Miller Distinguished Medical University of Vienna, Austria American Society of Professorship of Anesthesia Anesthesiologists PREVIOUS EMPLOYMENT and Perioperative Care, Best Anesthesia Interest Group Attending, Medical University of Vienna, Austria established 2015 in the US, 2015

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 14 Peer Reviewed Publications

Abla AA, Nelson J, Kim H, Hess CP, Tihan T, Lawton Barrett JS, Hirankarn S, Holford N, Hammer GB, Caruana E, Duchateau FX, Cornaglia C, Devaud ML, MT. Silent arteriovenous malformation hemorrhage Drover DR, Cohane CA, Anderson B, Dombrowski E, Pirracchio R. Tracheal intubation related and the recognition of “unruptured” arteriovenous Reece T, Zajicek A, Schulman SR. A hemodynamic complications in the prehospital setting. Emerg malformation patients who benefit from surgical model to guide blood pressure control during Med J. 2015 Nov;32(11):882-7. intervention. Neurosurgery. 2015 May;76(5):592-600; deliberate hypotension with sodium nitroprusside in Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, discussion 600. children. Front Pharmacol. 2015 Jul 28;6:151. Heung M, Okusa MD, Faubel S; AKI Advisory Group Abla AA, Rutledge WC, Seymour ZA, Guo D, Barry AE, Chaney MA, London MJ. Anesthetic of the American Society of Nephrology. Promoting Kim H, Gupta N, Sneed PK, Barani IJ, Larson D, management during cardiopulmonary bypass: a Kidney Function Recovery in Patients with AKI McDermott MW, Lawton MT. A treatment paradigm systematic review. Anesth Analg. 2015 Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct for high-grade brain arteriovenous malformations: Apr;120(4):749-69. 7;10(10):1859-67. volume-staged radiosurgical downgrading followed Beitler JR, Thompson BT, Matthay MA, Talmor D, Champigneulle B, Bellenfant-Zegdi F, Follin A, Lebard by microsurgical resection. J Neurosurg. 2015 Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Feb;122(2):419-32. C, Guinvarch A, Thomas F, Pirracchio R, Journois D. Estimating dead-space fraction for secondary Extracorporeal life support (ECLS) for refractory Abou-Arab MH, Feiner JR, Spigset O, Heier T. analyses of acute respiratory distress syndrome cardiac arrest after drowning: an 11-year experience. Alfentanil during rapid sequence induction with clinical trials. Crit Care Med. 2015 Resuscitation. 2015 Mar;88:126-31. thiopental 4 mg/kg and rocuronium 0.6 mg/kg: May;43(5):1026-35. Chau A, Markley JC, Juang J, Tsen LC. Cytokines in tracheal intubation conditions. Acta Anaesthesiol Bokoch MP, Behrends M, Neice A, Larson MD. the perinatal period – Part 1. Scand. 2015 Nov;59(10):1278-86. Int J Obstet Anesth. Fentanyl, an agonist at the mu opioid receptor, 2016 Jan 5. Alexander MD, Rebhun JM, Hetts SW, Kim AS, depresses pupillary unrest. Auton Neurosci. 2015 Chau A, , Juang J, Tsen LC. Cytokines in Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, May;189:68-74. Markley JC Halbach VV, Higashida RT, Cooke DL. Lesion location, the perinatal period – Part II. Int J Obstet Anesth. Borrat X, Valencia JF, Magrans R, Gimenez-Mila M, 2016 Jan 5. stability, and pretreatment management: factors Mellado R, Sendino O, Perez M, Nunez M, affecting outcomes of endovascular treatment for Jospin M, Jensen EW, Troconiz I, Gambus PL. Chen CL, Gelb AW, Dudley RA. Preoperative Testing vertebrobasilar atherosclerosis. J Neurointerv Surg. Sedation-analgesia with propofol and remifentanil: in Patients Undergoing Cataract Surgery. N Engl 2015 Mar 20. concentrations required to avoid gag reflex in upper J Med. 2015 Jul 16;373(3):285-6. American Geriatrics Society Expert Panel on gastrointestinal endoscopy. Anesth Analg. 2015 Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin Postoperative Delirium in Older Adults. (Inouye SK, Jul;121(1):90-6. WJ, Gelb AW, Maze M, Gropper MA, Dudley RA. Robinson T, Blaum C, Busby-Whitehead J, Brand OJ, Somanath S, Moermans C, Yanagisawa H, Preoperative medical testing in Medicare patients Boustani M, Chalian A, Deiner S, Fick D, Hutchison L, Hashimoto M, Cambier S, Markovics J, Bondesson undergoing cataract surgery. N Engl J Med. 2015 Johanning J, Katlic M, Kempton J, Kennedy M, AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Apr 16;372(16):1530-8. Kimchi E, Ko C, Leung J, Mattison M, Mohanty S, Baron JL, Nishimura SL. Transforming Growth Nana A, Needham D, Neufeld K, Richter H.) Christenson SA, Steiling K, van den Berge M, Factor- and Interleukin-1 Signaling Pathways Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Postoperative delirium in older adults: best practice Converge on the Chemokine CCL20 Promoter. Spira A, Woodruff PG. Asthma-COPD overlap. statement from the American Geriatrics Society. J Biol Chem. 2015 Jun 5;290(23):14717-28. J Am Coll Surg. 2015 Feb;220(2):136-48.e1. Clinical relevance of genomic signatures of type 2 Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum inflammation in chronic obstructive pulmonary American Geriatrics Society Expert Panel on AI. Transplant-mediated enhancement of spinal cord disease. Am J Respir Crit Care Med. 2015 Apr Postoperative Delirium in Older Adults. (Inouye SK, GABAergic inhibition reverses paclitaxel-induced 1;191(7):758-66. Robinson T, Blaum C, Busby-Whitehead J, Boustani mechanical and heat hypersensitivity. 2015 Pain. Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry M, Chalian A, Deiner S, Fick D, Hutchison L, Jun;156(6):1084-91. Johanning J, Katlic M, Kempton J, Kennedy M, D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Kimchi E, Ko C, Leung J, Mattison M, Mohanty S, Calello DP, Liu KD, Wiegand TJ, Roberts DM, Su H, Saeed MM. Endovascular biopsy: Technical Nana A, Needham D, Neufeld K, Richter H, Radcliff S, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, feasibility of novel endothelial cell harvesting devices Weston C, Patil S, Rocco G, Yue J, Aiello SE, Drootin Ghannoum M; Extracorporeal Treatments in assessed in a rabbit aneurysm model. Interv M, Ickowicz E, Samuel MJ.) American Geriatrics Poisoning Workgroup. Extracorporeal Treatment for Neuroradiol. 2015 Feb;21(1):120-8. Metformin Poisoning: Systematic Review and Society abstracted clinical practice guideline for Cui WW, Ramsay JG. Pharmacologic approaches Recommendations From the Extracorporeal postoperative delirium in older adults. J Am Geriatr to weaning from cardiopulmonary bypass and Treatments in Poisoning Workgroup. Crit Care Med. Soc. 2015 Jan;63(1):142-50. extracorporeal membrane oxygenation. Best Pract 2015 Aug;43(8):1716-30. Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Res Clin Anaesthesiol. 2015 Jun;29(2):257-70. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris Shotsberger KJ, Pollice LA, Buddadhumaruk P, Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, KN, Matthay MA, Ware LB; NIH NHLBI ARDS Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Network. Distinct molecular phenotypes of direct Peterson MW, Steingrub JS, White DB. A multicenter Angus DC, Matthay MA; RESTORE Study vs indirect ARDS in single-center and multicenter study of key stakeholders’ perspectives on Investigators and the Pediatric Acute Lung Injury and studies. Chest. 2015 Jun;147(6):1539-48. communicating with surrogates about prognosis in Sepsis Investigators Network. Protocolized sedation intensive care units. Ann Am Thorac Soc. 2015 Calfee CS, Matthay MA, Kangelaris KN, Siew ED, vs usual care in pediatric patients mechanically Feb;12(2):142-52. Janz DR, Bernard GR, May AK, Jacob P, Havel C, ventilated for acute respiratory failure: a randomized Bailly S, Pirracchio R, Timsit JF. What’s new in the Benowitz NL, Ware LB. Cigarette Smoke Exposure clinical trial. JAMA. 2015 Jan 27;313(4):379-89. and the Acute Respiratory Distress Syndrome. quantification of causal effects from longitudinal Curley MA, Wypij D, Matthay MA; RESTORE Study Crit Care Med. 2015 Sep;43(9):1790-7. cohort studies: a brief introduction to marginal Investigators. Sedation protocol for critically ill structural models for intensivists. Intensive Care Med. Caruana E, Chevret S, Resche-Rigon M, Pirracchio pediatric patients-reply. JAMA. 2015 May 2015 Jun 24. R. A new weighted balance measure helped to select 5;313(17):1754-5. the variables to be included in a propensity score model. J Clin Epidemiol. 2015 Dec;68(12):1415- continued on next page 1422.e2.

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 15 Peer Reviewed Publications continued Daniels KM, Yu EY, Maine RG, Corlew S, Bing S, Feiner JR, Gropper MA, Toy P, Lieberman J, Gennai S, Monsel A, Hao Q, Park J, Matthay MA, Hoffman WY, Gregory GA. Palatal fistula risk after Twiford J, Weiskopf RB. A Clinical Trial to Detect Lee JW. Microvesicles Derived From Human primary palatoplasty: a retrospective comparison of Subclinical Transfusion-induced Lung Injury during Mesenchymal Stem Cells Restore Alveolar Fluid humanitarian operations and tertiary hospitals. Surgery. Anesthesiology. 2015 Jul;123(1):126-35. Clearance in Human Lungs Rejected for Lancet. 2015 Apr 27;385 Suppl 2:S37. Transplantation. Am J Transplant. 2015 Feng X, Maze M, Koch LG, Britton SL, Hellman J. Sep;15(9):2404-12. De Pinto M, Naidu RK. Peripheral and Neuraxial Exaggerated Acute Lung Injury and Impaired Chemical Neurolysis for the Management of Antibacterial Defenses During Staphylococcus aureus Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin Intractable Lower Extremity Pain in a Patient with Infection in Rats with the Metabolic Syndrome. M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS; Terminal Cancer. Pain Physician. 2015 PLoS One. 2015 May 15;10(5):e0126906. EXTRIP workgroup. Extracorporeal treatment for Jul-Aug;18(4):E651-6. theophylline poisoning: systematic review and Fitzgerald A, Johnson M, Hirsch J, Rich MA, Fidler recommendations from the EXTRIP workgroup. DePianto DJ, Chandriani S, Abbas AR, Jia G, N’Diaye R. Inconsistent shock advisories for monomorphic VT Clin Toxicol (Phila). 2015 May;53(4):215-29. EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, and Torsade de Pointes – A prospective experimental Modrusan Z, Matthay MA, Kukreja J, Collard HR, study on AEDs and defibrillators. Resuscitation. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis Egen JG, Wolters PJ, Arron JR. Heterogeneous gene 2015 Jul;92:137-40. F, Davis PJ. Outcomes for extremely premature expression signatures correspond to distinct lung infants. Anesth Analg. 2015 Jun;120(6):1337-51. pathologies and biomarkers of disease severity in Fitzgerald A, Johnson M, Hirsch J, Rich M, Fidler R. Automated External Defibrillator Reponses to Golden MJ, Morrison LA, Kim H, Hart BL. Increased idiopathic pulmonary fibrosis. Thorax. 2015 Jan;70(1):48-56. Ventricular Arrhythmias. Resuscitation 2015 Oct 23. number of white matter lesions in patients with familial cerebral cavernous malformations. AJNR Flexman AM, Meng L, Gelb AW. Outcomes in Dong TT, Mellin-Olsen J, Gelb AW. Ketamine: a Am J Neuroradiol. 2015 May;36(5):899-903. neuroanesthesia: What matters most? growing global health-care need. Br J Anaesth. Can J 2015 Oct;115(4):491-3. Anaesth. 2015 Oct 23. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Donovan AL, Shimabukuro D. Protocol-Based RD, Rock P, Miller RR 3rd, Morris AH; National Heart Management of Severe Sepsis and Septic Shock. Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman Lung and Blood Institute Acute Respiratory Distress HI, Vasan RS, Kimmel PL, Hsu CY, Liu KD; CKD Current Anesthesiology Reports. 2015 Syndrome Clinical Trials Network. Fluid management Dec;5(4):407-418. Biomarkers Consortium. Urinary Biomarkers and with a simplified conservative protocol for the acute Risk of ESRD in the Atherosclerosis Risk in respiratory distress syndrome. Crit Care Med. 2015 Drover DR, Hammer GB, Barrett JS, Cohane CA, Communities Study. Clin J Am Soc Nephrol. Feb;43(2):288-95. Reece T, Zajicek A, Schulman SR. Evaluation of 2015 Nov 6;10(11):1956-63. sodium nitroprusside for controlled hypotension Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Freeman CM, Crudgington S, Stolberg VR, Brown JP, in children during surgery. Front Pharmacol. Vaman S, Guan AK, Evans-Reinsch Z, Braz J, 2015 Jul 6;6:136. Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Devor M, Abboud-Werner SL, Lanier LL, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O’Neal Lomvardas S, Basbaum AI. Injured sensory neuron- Du RH, Richmond BW, Blackwell TS Jr, Cates JM, WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff derived CSF1 induces microglial proliferation Massion PP, Ware LB, Lee JW, Kononov AV, Lawson PG, Zeidler M, Curtis JL. Design of a multi-center and DAP12-dependent pain. Nat Neurosci. 2016 WE, Blackwell TS, Polosukhin VV. Secretory IgA immunophenotyping analysis of peripheral blood, Jan;19(1):94-101. from submucosal glands does not compensate sputum and bronchoalveolar lavage fluid in the for its airway surface deficiency in chronic Subpopulations and Intermediate Outcome Measures Hammer GB, Lewandowski A, Drover DR, Rosen DA, obstructive pulmonary disease. Virchows Arch. in COPD Study (SPIROMICS). J Transl Med. 2015 Cohane C, Anand R, Mitchell J, Reece T, Schulman 2015 Dec;467(6):657-665. Jan 27;13:19. SR. Safety and efficacy of sodium nitroprusside during prolonged infusion in pediatric patients. Elobu AE, Kintu A, Galukande M, Kaggwa S, Mijjumbi Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre Pediatr Crit Care Med. 2015 Jun;16(5):397-403. C, Tindimwebwa J, Roche A, Dubowitz G, Ozgediz D, JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie Lipnick M. Research in surgery and anesthesia: D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel Han SJ, Englot DJ, Kim H, Lawton MT. Brainstem Challenges for post-graduate trainees in Uganda. PL, Liu KD; Chronic Kidney Disease Biomarkers arteriovenous malformations: anatomical subtypes, Educ Health (Abingdon). 2015 Jan-Apr;28(1):11-5. Consortium Investigators. Association of urinary assessment of “occlusion in situ” technique, and KIM-1, L-FABP, NAG and NGAL with incident microsurgical results. J Neurosurg Anesthesiol. Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren IN, end-stage renal disease and mortality in American 2015 Jan;122(1):107-17. Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Indians with type 2 diabetes mellitus. Diabetologia. Pires-Alves M, Wilson BA, Marks JD. Monoclonal 2015 Jan;58(1):188-98. Hannam JA, Borrat X, Trocóniz IF, Valencia JF, Antibodies that Inhibit the Proteolytic Activity of Jensen EW, Pedroso A, Muñoz J, Castellví-Bel S, Botulinum Neurotoxin Serotype/B. Toxins (Basel). Gambús PL, Trocóniz IF. Pharmacokinetic- Castells A, Gambús PL. Modeling Respiratory 2015 Aug 26;7(9):3405-3423. pharmacodynamic modelling in anaesthesia. Depression Induced by Remifentanil and Propofol Br J Clin Pharmacol. 2015 Jan;79(1):72-84. during Sedation and Analgesia Using a Continuous Fan Y, Geren IN, Dong J, Lou J, Wen W, Conrad F, Noninvasive Measurement of pCO2. J Pharmacol Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Exp Ther. 2016 Mar;356(3):563-73. Marks JD. Monoclonal Antibodies Targeting the Mellado R, Degos V, Vacas S, Maze M. Relation Alpha-Exosite of Botulinum Neurotoxin Serotype/A between acute and long-term cognitive decline Hao Q, Zhu YG, Monsel A, Gennai S, Lee T, Xu F, Inhibit Catalytic Activity. PLoS One. 2015 Aug after surgery: Influence of metabolic syndrome. Lee JW. Study of Bone Marrow and Embryonic Stem 14;10(8):e0135306. Brain Behav Immun. 2015 Jul 8. Cell-Derived Human Mesenchymal Stem Cells for Treatment of Escherichia coli Endotoxin-Induced Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Gelb AW, Enright A, Merry AF, Morriss W. The Bare Acute Lung Injury in Mice. Stem Cells Transl Med. Levy BD, Matthay MA. Human Mesenchymal Stem Minimum Requires Caution. World J Surg. 2015 2015 Jul;4(7):832-40. (Stromal) Cells Promote the Resolution of Acute Oct 19. Lung Injury in Part through Lipoxin A4. J Immunol. 2015 Aug 1;195(3):875-81. Gennai S, Monsel A, Hao Q, Liu J, Gudapati V, Barbier EL, Lee JW. Cell-based therapy for traumatic brain injury. 2015 Aug;115(2):203-12. Br J Anaesth. continued on next page

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 16 Peer Reviewed Publications continued Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Hill KD, Sampson MR, Li JS, Tunks RD, Schulman Kim H, Nelson J, Krings T, terBrugge KG, McCulloch Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron SR, Cohen-Wolkowiez M. Pharmacokinetics of CE, Lawton MT, Young WL, Faughnan ME; Brain JL, Krummel MF, Nishimura SL. TGF--Dependent intravenous sildenafil in children with palliated single Vascular Malformation Consortium HHT Investigator Dendritic Cell Chemokinesis in Murine Models of ventricle heart defects: effect of elevated hepatic Group. Hemorrhage rates from brain arteriovenous Airway Disease. J Immunol. 2015 Aug pressures. Cardiol Young. 2016 Feb;26(2):354-62. malformation in patients with hereditary hemorrhagic 1;195(3):1182-90. telangiectasia. Stroke. 2015 May;46(5):1362-4. Hirsch J, DePalma G, Tsai TT, Sands LP, Hawryluk G, Whetstone W, Saigal R, Ferguson A, Leung JM. Impact of intraoperative hypotension Kotloff RM, Blosser S, Fulda GJ, Malinoski D, Ahya Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, and blood pressure fluctuations on early VN, Angel L, Byrnes MC, DeVita MA, Grissom TE, Manley G. Mean Arterial Blood Pressure Correlates postoperative delirium after non-cardiac surgery. Halpern SD, Nakagawa TA, Stock PG, Sudan DL, with Neurological Recovery after Human Spinal Cord Br J Anaesth. 2015 Jan 23. Wood KE, Anillo SJ, Bleck TP, Eidbo EE, Fowler RA, Injury: Analysis of High Frequency Physiologic Data. Glazier AK, Gries C, Hasz R, Herr D, Khan A, Hirsch J. Hemodynamic Control and Delirium. J Neurotrauma. 2015 Aug 17. Landsberg D, Lebovitz DJ, Levine DJ, Mathur M, Naik 2015 January. Current Anesthesiology Reports. P, Niemann CU, Nunley DR, O’Connor KJ, Pelletier Heinonen JA, Litonius E, Pitkänen M, Rosenberg PH. Hirsch J, Generoso JR, Latoures R, Acar Y, Fidler RL. SJ, Rahman O, Ranjan D, Salim A, Sawyer RG, Shafer Incidence of severe local anaesthetic toxicity and T, Sonneti D, Spiro P, Valapour M, Vikraman- adoption of lipid rescue in Finnish anaesthesia Simulation Manikin Modifications for High-Fidelity Training of Advanced Airway Procedures. Sushama D, Whelan TP; Society of Critical Care departments in 2011-2013. Acta Anaesthesiol Scand. A A Case Rep. 2016 Jan 8. Medicine/American College of Chest Physicians/ 2015 Sep;59(8):1032-7. Association of Organ Procurement Organizations Howard BM, Kornblith LZ, Hendrickson CM, Redick Heinonen JA, Litonius E, Salmi T, Haasio J, Tarkkila Donor Management Task Force. Management of the P, Backman JT, Rosenberg PH. Intravenous lipid BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Potential Organ Donor in the ICU: Society of Critical emulsion given to volunteers does not affect Cohen MJ. Differences in degree, differences in kind: Care Medicine/American College of Chest Physicians/ characterizing lung injury in trauma. symptoms of lidocaine brain toxicity. Basic Clin J Trauma Acute Association of Organ Procurement Organizations 2015 Apr;78(4):735-41. Pharmacol Toxicol. 2015 Apr;116(4):378-83. Care Surg. Consensus Statement. Crit Care Med. 2015 Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger Jun;43(6):1291-325. Heinonen JA, Litonius E, Rosenberg PH. Response to ‘In Response to “Intravenous Lipid Emulsion Given to EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid Volunteers does not Affect Symptoms of Lidocaine LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin Brain Toxicity”’. Basic Clin Pharmacol Toxicol. 2015 Sly LM. Intravenous immunoglobulin skews Dec;117(6):362. BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, macrophages to an anti-inflammatory, IL-10- Whitehead KM, Nelson RG; CKD Biomarkers producing activation state. J Leukoc Biol. 2015 Hellman J. Addressing the Complications of Ebola Consortium. Cross-Disciplinary Biomarkers Research: Dec;98(6):983-94. and Other Viral Hemorrhagic Fever Infections: Lessons Learned by the CKD Biomarkers Consortium. Using Insights from Bacterial and Fungal Sepsis. Clin J Am Soc Nephrol. 2015 May 7;10(5):894-902. Kremer PH, Koeleman BP, Pawlikowska L, PLoS Pathog. 2015 Oct 1;11(10):e1005088. Weinsheimer S, Bendjilali N, Sidney S, Zaroff JG, Jayaraman S, Mabweijano J, Mijumbi C, Stanich M, Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA, Hendrickson CM, Crestani B, Matthay MA. Biology Dobbins S, Wolfe L, Lipnick M, Dicker R, Ozgediz D. Veldink JH, Kim H, Klijn CJ. Evaluation of genetic and pathology of fibroproliferation following the acute The Care of Injured Patients Admitted to Mulago risk loci for intracranial aneurysms in sporadic respiratory distress syndrome. Intensive Care Med. National Referral Hospital in Kampala, Uganda. arteriovenous malformations of the brain. J Neurol 2015 Jan;41(1):147-50. Emerg Med (Los Angel) 2015 5(4):270. Neurosurg Psychiatry. 2015 May;86(5):524-9. Hendrickson CM, Dobbins S, Redick BJ, Greenberg Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Krings T, Kim H, Power S, Nelson J, Faughnan ME, MD, Calfee CS, Cohen MJ. Misclassification of acute Matthay MA. Proteolytic regulation of epithelial Young WL, terBrugge KG; Brain Vascular respiratory distress syndrome after traumatic injury: sodium channels by urokinase plasminogen activator: Malformation Consortium HHT Investigator Group. The cost of less rigorous approaches. J Trauma Acute cutting edge and cleavage sites. J Biol Chem. 2015 Neurovascular manifestations in hereditary Care Surg. 2015 Sep;79(3):417-24. Feb 27;290(9):5241-55. hemorrhagic telangiectasia: imaging features and Hervey-Jumper SL, Li J, Lau D, Molinaro AM, Perry Kangelaris KN, Prakash A, Liu KD, Aouizerat B, genotype-phenotype correlations. AJNR Am J DW, Meng L, Berger MS. Awake craniotomy to Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Neuroradiol. 2015 May;36(5):863-70. maximize glioma resection: methods and technical Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Krombach JW, Edwards WA, Marks JD, Radke nuances over a 27-year period. J Neurosurg. 2015 Calfee CS. Increased expression of neutrophil- OC. Checklists and Other Cognitive Aids For Aug;123(2):325-39. related genes in patients with early sepsis-induced Emergency And Routine Anesthesia Care-A Survey ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun on the Perception of Anesthesia Providers From a Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, 1;308(11):L1102-13. Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Large Academic US Institution. Anesth Pain Med. Vijayan A; American Society of Nephrology Acute Kathiriya IS, Nora EP, Bruneau BG. Investigating 2015 Aug 22;5(4):e26300. Kidney Injury Advisory Group. Outpatient Dialysis for the transcriptional control of cardiovascular Krombach JW, Marks JD, Dubowitz G, Radke OC. Patients with AKI: A Policy Approach to Improving development. Circ Res. 2015 Feb 13;116(4):700-14. Development and Implementation of Checklists for Care. Clin J Am Soc Nephrol. 2015 Oct Routine Anesthesia Care: A Proposal for Improving 7;10(10):1868-74. Khakpour S, Wilhelmsen K, Hellman J. Vascular endothelial cell Toll-like receptor pathways in sepsis. Patient Safety. Anesth Analg. 2015 Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Innate Immun. 2015 Nov;21(8):827-46. Oct;121(4):1097-103. Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, , Abla AA, , McCulloch CE, Bervini D, Brett CM, Savic RM, Giacomini KM. The Effect of Kim H Nelson J Famotidine, a MATE1-Selective Inhibitor, on the Morgan MK, Stapleton C, Walcott BP, Ogilvy CS, Pharmacokinetics and Pharmacodynamics of Spetzler RF, Lawton MT. Validation of the supplemented Spetzler-Martin grading system for Metformin. Clin Pharmacokinet. 2015 Nov 23. brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery. 2015 Jan;76(1):25-31; discussion 31-2; quiz 32-3. continued on next page

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 17 Peer Reviewed Publications continued Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Makino H, Hokamura K, Natsume T, Kimura T, Kamio Markin C, Garnett ET, Degryse AL, Mitchell DB, Howard J, Fang X, Bhat S, Huynh KM, O’Kane CM, Y, Magata Y, Namba H, Katoh T, Sato S, Hashimoto Polosukhin VV, Rickman OB, Choi L, Cheng DS, Ingram RJ, Muir RR, McAuley DF, Matthay MA, T, Umemura K. Successful serial imaging of the McConaha ME, Jones BR, Gleaves LA, McMahon FB, Sheppard D. Unexpected Role for Adaptive abTh17 mouse cerebral arteries using conventional 3-T Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Cells in Acute Respiratory Distress Syndrome. J magnetic resonance imaging. J Cereb Blood Flow Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Immunol. 2015 Jul 1;195(1):87-95. Metab. 2015 Sep;35(9):1523-7. Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Matthay MA, Ware LB. Resolution of Alveolar Edema Blackwell TS. Extensive phenotyping of individuals at Mallick P, Reiter RE, Wu AM. A fully human scFv in Acute Respiratory Distress Syndrome. Physiology risk for familial interstitial pneumonia reveals clues to phage display library for rapid antibody fragment and Biology. Am J Respir Crit Care Med. 2015 Jul reformatting. 2015 May 19. 15;192(2):124-5. the pathogenesis of interstitial lung disease. Am J Protein Eng Des Sel. pii: gzv024. Respir Crit Care Med. 2015 Feb 15;191(4):417-26. Matthay MA. Saving lives with high-flow nasal Lilly LE, Bonaventura J, , Block BA. oxygen. 2015 Jun 4;372(23):2225-6. Larson MD, Behrends M. Portable infrared Lipnick MS N Engl J Med. Effect of temperature acclimation on red blood cell pupillometry: a review. Anesth Analg. 2015 Matthay MA. Therapeutic potential of mesenchymal Jun;120(6):1242-53. oxygen affinity in Pacific bluefin tuna (Thunnus orientalis) and yellowfin tuna (Thunnus albacares). stromal cells for acute respiratory distress syndrome. 2015 Mar;12 Suppl 1:S54-7. Larson MD, Gupta DK. Pupillary Reflex Dilation to Comp Biochem Physiol A Mol Integr Physiol. Ann Am Thorac Soc. Predict Movement: A Step Forward Toward Real- 2015 Mar;181:36-44. Matthay MA. Biomarkers to exclude the diagnosis time Individualized Intravenous Anesthetics. of ventilator-associated pneumonia. Lin N, Han R, Zhou J, Gelb AW. Mild Sedation Thorax. Anesthesiology. 2015 May;122(5):961-3. Exacerbates or Unmasks Focal Neurologic 2015 Jan;70(1):5-6. Lawton MT, Rutledge WC, Kim H, Stapf C, Dysfunction in Neurosurgical Patients with Maze M. Preclinical neuroprotective actions of Whitehead KJ, Li DY, Krings T, terBrugge K, Supratentorial Brain Mass Lesions in a Drug- xenon and possible implications for human Kondziolka D, Morgan MK, Moon K, Spetzler RF. specific Manner.Anesthesiology. 2016 Jan 12. therapeutics: a narrative review. Can J Anaesth. Brain arteriovenous malformations. Nature Reviews 2016 Feb;63(2):212-226. Epub 2015 Oct 27. Lipshutz AK, Caldwell JE, Robinowitz DL, Disease Primers. 2015 15008. Gropper MA. An analysis of near misses identified McKay RE, Hall KT, Hills N. The Effect of Anesthetic Lee JW, Rocco PR, Pelosi P. Mesenchymal stem cell by anesthesia providers in the intensive care unit. Choice (Sevoflurane Versus Desflurane) and therapy for acute respiratory distress syndrome: BMC Anesthesiol. 2015 Jun 17;15:93. Neuromuscular Management on Speed of Airway a light at the end of the tunnel? Anesthesiology. Reflex Recovery. 2016 Liu KD, Hsu CY. When change is not a good thing. Anesth Analg. 2015 Feb;122(2):238-40. Feb;122(2):393-401. Clin Chem. 2015 Jul;61(7):897-9. Lee SM, Takemoto S, Wallace AW. Association Melia U, Vallverdu M, Jospin M, Valencia JF, between Withholding Angiotensin Receptor Blockers Liu K, Liu H, Gao WD, Meng L. Cerebral circulation and ischemia: How to monitor it during surgery? Jensen EW, Gambus PL, Perera Lluna A, Caminal P. in the Early Postoperative Period and 30-day Interaction between EEG and drug concentration to Transl Perioper Pain Med. 2015 2(1):2-8. Mortality: A Cohort Study of the Veterans Affairs predict response to noxious stimulation during Healthcare System. Anesthesiology. 2015 Liu KD, Yang W, Go AS, Anderson AH, Feldman HI, sedation-analgesia: effect of the A118G genetic Aug;123(2):288-306. Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, polymorphism. Conf Proc IEEE Eng Med Biol Soc. Miller ER 3rd, Rosas SE, Steigerwalt S, Tao K, Weir 2014 2014;2014:4298-301. Lee SM, Takemoto S, Wallace AW. In Reply. MR, Hsu CY; CRIC Study Investigators. Urine Anesthesiology. 2016 Feb;124(2):513-4. neutrophil gelatinase-associated lipocalin and risk of Melia U, Vallverdú M, Borrat X, Valencia JF, Jospin M, Jensen EW, , Caminal P. Lee SM. Landry J, Jones PM, Buhrmann O, Morley- cardiovascular disease and death in CKD: results Gambus P Forster P. Long-term Quit Rates After a Perioperative from the Chronic Renal Insufficiency Cohort (CRIC) Prediction of Nociceptive Responses during Sedation by Linear and Non-Linear Measures of EEG Signals Smoking Cessation Randomized Controlled Trial. Study. Am J Kidney Dis. 2015 Feb;65(2):267-74. in High Frequencies. 2015 Apr Anes Analg. 2015 Mar;120(3):582-7. PLoS One. London MJ. From Durban to Boston, a “modest 22;10(4):e0123464. Leung JM, Sands LP, Newman S, Meckler G, Xie Y, proposal” to improve perioperative cardiovascular Meng L, Berger MS, Gelb AW. The Potential Benefits Gay C, Lee K. Preoperative Sleep Disruption and risk stratification. Anesth Analg. 2015 of Awake Craniotomy for Brain Tumor Resection: Postoperative Delirium. J Clin Sleep Med. 2015 Mar;120(3):515-8. Aug 15;11(8):907-13. An Anesthesiologist’s Perspective. J Neurosurg Long LS, Wolpaw JT, Leung JM. Sensitivity and Anesthesiol. 2015 Oct;27(4):310-7. Leventhal TM, Liu KD. What a Nephrologist Needs to specificity of the animal fluency test for predicting Meng L, Gelb AW. Regulation of cerebral Know About Acute Liver Failure. Adv Chronic Kidney postoperative delirium. Can J Anaesth. 2015 autoregulation by carbon dioxide. Dis. 2015 Sep;22(5):376-81. Jun;62(6):603-8. Anesthesiology. 2015 Jan;122(1):196-205. Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas Lu Y, McDonagh DL, Meng L. Anesthetic care , . Cerebral oximetry: Three SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, for acute ischemic stroke: facts and aspirations. Meng L Gelb AW questions to ask. Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, J Anesth Perioper Med. 2015 2(5):283-6. Colombian Journal of Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Anesthesiology 2015 43(1):52-56. Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan Meng L, Hall M, Settecase F, Higashida RT, Gelb WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR. Multidimensional AW. Monitoring cerebral tissue oxygen saturation at Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future frontal and parietal regions during carotid artery Research Directions in Asthma: An NHLBI Working Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar stenting. J Anesth. 2015 Dec 16. Group Report. Am J Respir Crit Care Med. 2015 Aug 25. Spinal Cord Injury. J Neurotrauma. 2016 Feb 1. Meng L, Han SJ, Rollins MD, Gelb AW, Chang EF. Awake brain tumor resection during pregnancy: Decision making and technical nuances. J Clin Neurosci. 2016 Feb;24:160-2. continued on next page

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 18 Peer Reviewed Publications continued

Meng L, Hou W, Chui J, Han R, Gelb AW. Cardiac Nurok M, Cohen N. Distraction Implications for fluorescence optical imaging. Am J Physiol Lung Cell Output and Cerebral Blood Flow: The Integrated the Practice of Anesthesia. Int Anesthesiol Clin. Mol Physiol. 2015 Aug 15;309(4):L414-24. Regulation of Brain Perfusion in Adult Humans. 2015 Summer;53(3):116-26. Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Anesthesiology. 2015 Nov;123(5):1198-208. Olmos A, Feiner J, Hirose R, Swain S, Blasi A, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Meng L, Li J, Gelb AW. Practice Trends and Roberts JP, Niemann CU. Impact of a quality Manley GT, Dhall SS. Complications and outcomes of Research Priorities of Neurosurgical Anesthesia. improvement project on deceased organ donor vasopressor usage in acute traumatic central cord J Anesth Perioper Med. 2015 2(5):277-82. management. Prog Transplant. 2015 syndrome. J Neurosurg Spine. 2015 Jul 31:1-7. Dec;25(4):351-60. Meng L, Li J, Lu Y, Sun D, Tao YX, Liu R, Luo JJ. Romig M, Tropello SP, Dwyer C, Wyskiel RM, Ravitz Ketamine - A Multifaceted Drug. Transl Perioper Pain Osorio JA, Breshears JD, Arnaout O, Simon NG, A, Benson J, Gropper MA, Pronovost PJ, Sapirstein Med. 2015 1(2):20-26. Hastings-Robinson AM, Aleshi P, Kliot M. A. Developing a Comprehensive Model of Intensive Ultrasound-guided percutaneous injection of Care Unit Processes: Concept of Operations. Meng L, Settecase F, Xiao J, Yu Z, Flexman AM, J Patient methylene blue to identify nerve pathology and guide 2015 Apr 23. Higashida RT. Initial clinical experience with Saf. surgery. Neurosurg Focus. 2015 Sep;39(3):E2. near-infrared spectroscopy in assessing cerebral Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic tissue oxygen saturation in cerebral vasospasm Pasero D, Koeltz A, Placido R, Fontes Lima M, Haun O, Hubmayr RD, Gropper MA, Koenigsberg M, before and after intra-arterial verapamil injection. O, Rienzo M, Marrache D, Pirracchio R, Safran D, Wilson GA, Matthay MA, Toy P, Murphy EL; TRALI J Clin Neurosci. 2016 Jan 4. Cholley B. Improving ultrasonic measurement of Study Group. Cytokines and clinical predictors in Meng L, Weston SD, Chang EF, Gelb AW. Awake diaphragmatic excursion after cardiac surgery using distinguishing pulmonary transfusion reactions. craniotomy in a patient with ejection fraction of 10%: the anatomical M-mode: a randomized crossover Transfusion. 2015 Aug;55(8):1838-46. study. Intensive Care Med. 2015 Apr;41(4):650-6. considerations of cerebrovascular and cardiovascular Sanders RD, Grover V, Goulding J, Godlee A, Gurney physiology. J Clin Anesth. 2015 May;27(3):256-61. Pawlikowska L, Nelson J, Guo DE, McCulloch CE, S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T. Meybohm P, Bein B, Brosteanu O, Cremer J, Lawton MT, Young WL, Kim H, Faughnan ME; Immune cell expression of GABAA receptors and Gruenewald M, Stoppe C, Coburn M, Schaelte G, Brain Vascular Malformation Consortium HHT the effects of diazepam on influenza infection. Böning A, Niemann B, Roesner J, Kletzin F, Strouhal Investigator Group. The ACVRL1 c.314-35A>G J Neuroimmunol. 2015 May 15;282:97-103. U, Reyher C, Laufenberg-Feldmann R, Ferner M, polymorphism is associated with organ vascular malformations in hereditary hemorrhagic Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Brandes IF, Bauer M, Stehr SN, Kortgen A, Wittmann Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, M, Baumgarten G, Meyer-Treschan T, Kienbaum P, telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. Matthay MA; NHLBI ARDS Network. Erratum to: Heringlake M, Schön J, Sander M, Treskatsch S, plasma soluble thrombomodulin levels are associated Am J Med Genet A. 2015 Jun;167(6):1262-7. Smul T, Wolwender E, Schilling T, Fuernau G, with mortality in the acute respiratory distress Hasenclever D, Zacharowski K; RIPHeart Study Pirracchio R, Petersen ML, van der Laan M. syndrome. Intensive Care Med. 2015 Mar;41(3):574. Collaborators. A Multicenter Trial of Remote Ischemic Improving propensity score estimators’ robustness Preconditioning for Heart Surgery. N Engl J Med. to model misspecification using super learner. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, 2015 Oct 8;373(15):1397-407. Am J Epidemiol. 2015 Jan 15;181(2):108-19. Matthay MA; NHLBI ARDS Network. Plasma soluble Michel LV, Shaw J, MacPherson V, Barnard D, Pirracchio R, Petersen ML, Carone M, Rigon MR, thrombomodulin levels are associated with mortality Bettinger J, D’Arcy B, Surendran N, Hellman J, Chevret S, van der Laan MJ. Mortality prediction in in the acute respiratory distress syndrome. Intensive Pichichero ME. Dual orientation of the outer intensive care units with the Super ICU Learner Care Med. 2015 Mar;41(3):470-8. membrane lipoprotein Pal in Escherichia coli. Algorithm (SICULA): a population-based study. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD; Microbiology. 2015 Jun;161(6):1251-9. Lancet Respir Med. 2015 Jan;3(1):42-52. National Heart, Lung, and Blood Institute Acute Moazed F, Calfee CS. Clearing the air. Smoking and Potts MB, Lau D, Abla AA, Kim H, Young WL, Respiratory Distress Syndrome Network. Body incident asthma in adults. Am J Respir Crit Care Med. Lawton MT; UCSF Brain AVM Study Project. Current temperature and mortality in patients with acute 2015 Jan 15;191(2):123-4. surgical results with low-grade brain arteriovenous respiratory distress syndrome. Am J Crit Care. 2015 Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, malformations. J Neurosurg. 2015 Apr;122(4):912-20. Jan;24(1):15-23. Rosenzwajg M, Matthay MA, Lee JW. Therapeutic Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi Effects of Human Mesenchymal Stem Cell-derived Lowell C, Hellman J. Lung Ischemia-Reperfusion P, Wu Z, Scaria A, Su H. Inhibition of pathological Microvesicles in Severe Pneumonia in Mice. Am is a Sterile Inflammatory Process Influenced by brain angiogenesis through systemic delivery of AAV 2015 Aug 1;192(3):324-36. J Respir Crit Care Med. Commensal Microbiota in Mice. Shock. 2015 vector expressing soluble FLT1. Gene Ther. 2015 Morrissey KM, Stocker SL, Chen EC, Castro RA, Sep;44(3):272-9. Nov;22(11):893-900. Brett CM, Giacomini KM. The Effect of Nizatidine, a Prielipp RC, Morell RC, Coursin DB, Brull SJ, Barker Shieh SC, Liu KD. Finding the key to dialysis MATE2K Selective Inhibitor, on the Pharmacokinetics SJ, Rice MJ, Vender JS, Cohen NH, Warner MA, catheter lock. Am J Respir Crit Care Med. 2015 and Pharmacodynamics of Metformin in Healthy Apfelbaum JL. Dialogue on the Future of May 1;191(9):972-4. Volunteers. Clin Pharmacokinet. 2015 Oct 27. Anesthesiology. Anesth Analg. 2015 Shim J, DePalma G, Sands LP, Leung JM. Prognostic Neuschwander A, Couffin S, Huynh TM, Cholley B, May;120(5):1152-4. Significance of Postoperative Subsyndromal de Villechenon GP, Achouh P, Fabiani JN, Safran D, Prielipp RC, Morell RC, Coursin DB, Brull SJ, Delirium. Psychosomatics. 2015 May 15. pii: Pirracchio R. Determinants of Transcutaneous Ear Barker SJ, Rice MJ, Vender JS, Cohen NH. The S0033-3182(15)00085-7. Lobe CO2 Tension (PtCO2) at 37°C During On-Pump Future of Anesthesiology: Should the Perioperative Cardiac Surgery. J Cardiothorac Vasc Anesth. Shimada K, Furukawa H, Wada K, Wei Y, Tada Y, Surgical Home Redefine Us? Anesth Analg. 2015 Aug;29(4):917-23. 2015 May;120(5):1142-8. Kuwabara A, Shikata F, Kanematsu Y, Lawton MT, Kitazato KT, Nagahiro S, Hashimoto T. Niemann CU, Feiner J, Swain S, Bunting S, Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Angiotensin-(1-7) protects against the development Friedman M, Crutchfield M, Broglio K, Hirose R, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy of aneurysmal subarachnoid hemorrhage in mice. Roberts JP, Malinoski D. Therapeutic Hypothermia in SP. Visualization of Fra-1/AP-1 activation during 2015 Jul;35(7):1163-8. Deceased Organ Donors and Kidney-Graft Function. J Cereb Blood Flow Metab. LPS-induced inflammatory lung injury using N Engl J Med. 2015 Jul 30;373(5):405-14. continued on next page

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 19 Peer Reviewed Publications continued Shimada K, Furukawa H, Wada K, Korai M, Wei Y, Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Weyker P, Webb C, Naidu RK. Perioperative pain Tada Y, Kuwabara A, Shikata F, Kitazato KT, Nagahiro Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, management in a patient with anaphylaxis to full S, Lawton MT, Hashimoto T. Protective Role of Mabray MC, Pan JZ, Manley GT, Dhall SS. The mu-agonists presenting for head and neck salvage Peroxisome Proliferator-Activated Receptor- in the Brain and Spinal Injury Center score: a novel, simple, surgery. Pain Physician. 2015 Jan-Feb;18(1):E83-5. Development of Intracranial Aneurysm Rupture. and reproducible method for assessing the severity Weyker PD, Webb CAJ, Pham TM. Workup and Stroke. 2015 Jun;46(6):1664-72. of acute cervical spinal cord injury with axial Management of Persistent Neuralgia following T2-weighted MRI findings. J Neurosurg Spine. 2015 Shunk KA, Zimmet J, Cason B, Speiser B, Tseng EE. Jul 10:1-10. Nerve Block. Case Reports in Anesthesiology 2016 Development of a Veterans Affairs hybrid operating 2016:9863492. room for transcatheter aortic valve replacement in Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Whitlock EL, Behrends M. Blood Transfusion and the cardiac catheterization laboratory. JAMA Surg. Feldmann M, Ma D, Akassoglou K, Maze M. Postoperative Delirium 2015 Mar 1;150(3):216-22. Stimulation of the 7 nicotinic acetylcholine receptor Current Anesthesiology protects against neuroinflammation after tibia Reports 2015 Mar;5(1):24-32. Smul TM, Eilers H, Stumpner J. [Nephroprotection fracture and endotoxemia in mice. Mol Med. 2015 – anaesthetic management of renal transplantation]. Whitlock EL, Feiner JR, Chen LL. Perioperative Mar 17;20:667-75. Mortality, 2010 to 2014: A Retrospective Cohort Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Sep;50(9):566-75. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Study Using the National Anesthesia Clinical Outcomes Registry. 2015 Winters JL, Gropper MA, Hubmayr RD, Matthay Anesthesiology. Solorzano C, Villafuerte D, Meda K, Cevikbas F, Dec;123(6):1312-21. MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn- Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair , , Auerbach AD. Harms Smith IJ, Guan Z, Basbaum AI. Primary afferent Whitlock EL Kim H DC, Sanchez Rosen R, Looney MR. Recipient clinical associated with single unit perioperative transfusion: and spinal cord expression of gastrin-releasing risk factors predominate in possible transfusion- peptide: message, protein, and antibody concerns. retrospective population based analysis. BMJ. 2015 related acute lung injury. Transfusion. 2015 Jun 12;350:h3037. J Neurosci. 2015 Jan 14;35(2):648-57. May;55(5):947-52. Stumpner J, Lange M, Roewer N, Kranke P, Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Tranah GJ, Yaffe K, Katzman SM, Lam ET, , , Wang J, Gray NS, . Smul TM. [Perioperative myocardial protection in Sundar S Prakash A Hellman J Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Extracellular signal-regulated kinase 5 promotes non-cardiac surgery]. Anasthesiol Intensivmed Kritchevsky S, Thomas F, Newman AB, Harris TB, acute cellular and systemic inflammation. Notfallmed Schmerzther. 2015 Sep;50(9):546-55. Sci Signal. Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, 2015 Aug 25;8(391):ra86. Stumpner J, Tischer-Zeitz T, Lotz C, Umminger J, Browner WS, Cummings SR; Health, Aging and Body Wilson J, McKenna D, , . Neuwirth A, Smul TM, Redel A, Kehl F, Roewer N, Composition Study. Mitochondrial DNA Heteroplasmy Liu KD Matthay MA Lange M. The second window of desflurane-induced Associations With Neurosensory and Mobility Mesenchymal stem (stromal) cells for treatment of preconditioning is mediated by STAT3: role of Pim-1 Function in Elderly Adults. J Gerontol A Biol Sci acute respiratory distress syndrome – authors’ reply. 2015 Apr;3(4):e12-3. kinase. Acta Anaesthesiol Scand. 2016 Med Sci. 2015 Aug 31. Lancet Respir Med. Jan;60(1):103-16. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Looney MR, Matthay MA, Rock JR, Chapman HA. Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa E5, Leavitt A, McKenna D, Thompson BT, . Z, Su H, Cooke DL. Endovascular biopsy: strategy Lineage-negative progenitors mobilize to regenerate Matthay MA for analyzing gene expression profiles of individual lung epithelium after major injury. Nature. 2015 Mesenchymal stem (stromal) cells for treatment of endothelial cells obtained from human vessels. Jan 29;517(7536):621-5. ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Sep;7:157-65. 2015 Jan;3(1):24-32. Biotechnology Reports. Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang , Agusti A, Roche N, Singh D, Martinez Sun Z, Yue Y, Leung CC, Chan MT, Gelb AW; Study R, Liu Z, Zhang J. Recombinant human erythropoietin Woodruff PG Group for Perioperative Stroke In China (POSIC); improves the neurofunctional recovery of rats FJ. Current concepts in targeting chronic obstructive Study Group for Perioperative Stroke In China POSIC. following traumatic brain injury via an increase in pulmonary disease pharmacotherapy: making Clinical diagnostic tools for screening of perioperative circulating endothelial progenitor cells. Transl Stroke progress towards personalised management. stroke in general surgery: a systematic review. Res. 2015 Feb;6(1):50-9. Lancet. 2015 May 2;385(9979):1789-98. 2016 Mar;116(3):328-38. Br J Anaesth. Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Yang ST, Rodriguez-Hernandez A, Walker EJ, Swann NC, de Hemptinne C, Maher RB, Stapleton Lawton MT. Endovascular treatment of severe acute Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to CA, Meng L, Gelb AW, Starr PA. Motor System basilar artery occlusion. J Clin Neurosci. 2015 Interactions in the Beta Band Decrease during Jan;22(1):195-8. external jugular vein anastomosis. J Vis Exp. 2015 Loss of Consciousness. 2016 Jan 27;(95):50472. J Cogn Neurosci. Ware LB, Calfee CS. Biomarkers of ARDS: what’s Jan;28(1):84-95. new? Intensive Care Med. 2015 Jul 15. Yu Y, Lu Y, Meng L, Han R. Monitoring cerebral , Vail TP, Houman J, Barnes CL. ischemia using cerebral oximetry: pros and cons. Takemoto S Wei H, Cao X, Zeng Q, Zhang F, Xue Q, Luo Y, Lee What defines a high-volume hip or knee surgeon J Biomed Res. 2015 Oct 28;30. JW, Yu B, Feng X. Ghrelin inhibits proinflammatory in the United States? J Surg Orthop Adv. 2015 responses and prevents cognitive impairment in Zakus P, Gelb AW, Flexman AM. A survey of Summer;24(2):87-90. septic rats. Crit Care Med. 2015 May;43(5):e143-50. mentorship among Canadian anesthesiology residents. Can J Anaesth. 2015 Sep;62(9):972-978. Weiser TG, Makasa EM, Gelb AW. Improving perioperative outcomes in low-resource countries: Zeng MY, Cisalpino D, Varadarajan S, Hellman J, It can’t be fixed without data.Can J Anaesth. Warren HS, Cascalho M, Inohara N, Núñez G. Gut 2015 Dec;62(12):1239-1243. Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. 2016 Mar 15;44(3):647-58.

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 20 Active Research Grants Jon Matt Aldrich Marek Brzezinski Monica Harbell Jan Hirsch Jens Krombach Principal Investigator Principal Investigator Principal Investigator Richard Fidler Principal Investigator UC San Diego/UCOP, Anesthesia Dept, Anesthesia Dept, Principal Investigator Anesthesia Dept, 1/1/2014–12/31/2016 7/1/2014–6/30/2016 10/1/2014–9/30/2016 VA Office of Academic Affairs, 10/1/2014–9/30/2016 Advanced Resuscitation Anesthesia Department Anesthesia Department 7/1/2013–6/30/2016 Anesthesia Department Training (ART) Research Award Clinical Research Award VA Advanced Fellowship Clinical Research Award $113,599 $70,800 $16,000 Program in Simulation $16,000 Principal Investigator $700,000 Pedram Aleshi Lee-lynn Chen Mt Zion Health Fund, Philip Kurien 4/1/2015–3/31/2017 Irfan Kathiriya Principal Investigator Principal Investigator Enhanced Recovery Program Principal Investigator Anesthesia Dept, UCSF Center for Healthcare for Total Mastectomy Patients Principal Investigator Anesthesia Dept, 10/1/2014–9/30/2016 Value, 7/1/2015–6/30/2016 7/1/2015–6/30/2016 $29,420 Anesthesia Dept, Anesthesia Department Perioperative Surgical Homes 7/1/2015–6/30/2016 Anesthesia Department Clinical Research Award $50,000 Anesthesia Department Research Award $16,000 Tomoki Hashimoto Research Award $40,000 Helene Choquet Principal Investigator $80,000 Principal Investigator Benedict Alter NIH/NINDS, Principal Investigator FAER, 1/1/2016–12/31/2017 Principal Investigator 3/15/2011–2/28/2017 Accelerated Recovery of Principal Investigator American Heart Association, FAER, 7/1/2013–6/30/2016 Intracranial aneurysm Gene regulation during Circadian Rhythm and Foundation for Anesthesia 7/1/2014–9/30/2016 pathogenesis-roles of Monocyte Function Education & Research, Contribution of Cardio- cardiac differentiation vascular remodeling and $175,000 $175,000 7/1/2016-6/30/2017 vascular Risk Factors and inflammation Mechanisms and Inflammation to Familial $1,674,637 Principal Investigator translational application CCM1 Disease Severity Society for Pediatric Michael Lawton of conditioned analgesia $94,000 Principal Investigator Anesthesia, in post-operative pain NIH/NINDS, Principal Investigator 1/1/2016–12/31/2016 NIH/NINDS, $75,000 9/1/2013–5/31/2018 Mechanisms for Richard Fidler The Role of Mast Cells in 9/30/2014–7/31/2019 Ventricular Septation Brain Vascular Malformation Principal Investigator the Pathophysiology of $25,000 Roland Bainton Intracranial Aneurysm Consortium: Predictors of UCSF Catalyst Program, Clinical Course Principal Investigator 7/1/2015–7/1/2016 $1,726,306 Anesthesia Dept, SuperAlarm Helen Kim $6,179,248 7/1/2015–6/30/2016 $40,000 Judith Hellman Principal Investigator Anesthesia Department NIH/NINDS, Jae-Woo Lee Research Award Program Director Michael Gropper 7/1/2013–6/30/2018 Principal Investigator $80,000 NIH/NIGMS, Predictors of spontaneous 7/1/2012–6/30/2017 NIH/NHLBI, Principal Investigator Principal Investigator cerebral AVM hemorrhage 5/1/2012–4/30/2017 Gordon and Betty Moore Comprehensive Anesthesia $2,335,649 NIH/NINDS, Research Training Human mesenchymal stem 2/1/2013–1/31/2017 Foundation, cell microvesicles for the Co-Leader, Center Grant Discovering fundamental 10/1/2014–6/30/2016 $1,034,946 treatment of acute lung injury metabolic control processes Implementation Grant for Project 1 Principal Investigator NIH/NINDS, $1,899,191 of the blood brain barrier EMERGE at University of California, San Francisco San Francisco Foundation, 9/30/2014–7/31/2019 $430,002 1/1/2016–12/31/2016 $4,000,000 Modifiers of disease severity Jae-Woo Lee San Francisco and progression in cerebral Matthias Behrends Principal Investigator Foundation Award cavernous malformation Co-Principle Investigator FAER, 1/1/2016–12/31/2016 $125,000 $563,366 Nina Ireland Program Principal Investigator 2016 Medical Student for Lung Health, Anesthesia Dept, Anesthesia Research Principal Investigator 1/1/2015–12/31/2016 10/1/2014–9/30/2016 Fellowship Program International Anesthesia Kerstin Kolodzie Integrin Alpha-v Beta-5 Drive Research Society, Anesthesia Department $6,200 Pulmonary Vascular Leak Clinical Research Award 7/1/2015–6/30/2018 Principal Investigator from Ischemia-Reperfusion in Endothelial Inflammatory Anesthesia Dept, $16,000 Lung Transplantation Pathways in Septic 10/1/2014–9/30/2016 Zhonghui Guan $24,083 Vasculopathy and Organ Injury Anesthesia Department Philip Bickler Principal Investigator $750,000 Clinical Research Award John Feiner NIH/NINDS, $6,000 9/30/2012–8/31/2017 Principal Investigator Principal Investigator Epigenetic regulation in Massachusetts General Various Industry Sponsors, neuropathic pain Hospital/DARPA, 9/1/1986–12/31/2016 $947,160 11/1/2015–10/31/2017 Accuracy of pulse oximeters Species Inspired Research for with profound hypoxia Innovative Treatments (SPIRIT) $400,000 $276,000

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UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 21 Active Research Grants continued Susan M. Lee James Marks Ludmila Pawlikowska Mark Schumacher Pekka Talke Principal Investigator Principal Investigator Co-Leader, Center Grant Core Principal Investigator Principal Investigator Anesthesia Dept, NIH/NIAID, NIH/NINDS, Anesthesia Dept, Masimo, 7/1/2014–6/30/2016 2/1/2013–1/31/2018 9/30/2014–7/31/2019 7/1/2015–6/30/2016 8/14/2013–12/31/2016 Anesthesia Department Generation of therapeutic Genetic and Statistical Anesthesia Department Noninvasive hemoglobin Research Award antibodies for serotype Analysis Core (GSAC) Research Award (SpHb) measured with Pulse $18,569 F botulism $417,458 $80,000 CO-Oximetry technology $5,448,316 $42,266 Project Director Jacqueline Leung Principal Investigator Romain Pirracchio NIH/NIDA, CA Dept of Public Health, 7/15/2015–7/14/2016 Arthur Wallace Principal Investigator 10/15/2012–10/14/2016 Principal Investigator NIH Pain Consortium NIH/NIA, 6/1/2015–5/31/2017 Identification of monoclonal UC Berkeley/PCORI, Centers of Excellence Principal Investigator The Effects of Light vs Deep antibody combinations 1/26/2015–3/31/2017 in Pain Education NCIRE, 3/1/2012–3/1/2017 Anesthesia on Postoperative Semiparametric Causal Perioperative Outcomes that neutralize variant $77,867 Cognitive Outcomes botulinum neurotoxins Inference Methods for Epidemiologic Consortium $444,033 Adaptive Statistical Learning $150,000 $0 in Trauma Patient-Centered David Shimabukuro Principal Investigator Outcomes Research Michael Gropper Principal Investigator Bin Liu NIH/NCI, $141,170 Sponsor VA National Anesthesia Office, Principal Investigator 9/24/2014–8/31/2019 Principal Investigator Antibody Technology Vanderbilt University/NIH, 1/2/2014–1/1/2017 NIH/NCI, 8/6/2012–7/31/2017 Arun Prakash Budde VA_AnesQIP Internalizing human Research Center 8/15/2012–6/30/2017 antibody-targeted nanosized $5,779,613 Principal Investigator The MENDS II Study $100,000 siRNA therapeutics Anesthesia Dept, $200,304.45 $1,607,090 Principal Investigator 7/1/2015–6/30/2016 NIH/NIAID, Xiaobing Yu Anesthesia Department Una Srejic Principal Investigator 6/20/2014–5/31/2017 Research Award Principal Investigator Trispecific Monoclonal Multiple Myeloma Research $25,000 Principal Investigator FAER, 7/1/2013–6/30/2016 Foundation, Antibody for Botulinum Anesthesia Dept, Treating neuropathic pain with 10/1/2015–9/30/2017 Neurotoxin Intoxication Principal Investigator 7/1/2015–6/30/2016 spinal cord transplants of Translational Development Therapy NIH/NIGMS, Anesthesia Department genetically modified human of a Novel Antibody-Drug $1,336,571 2/1/2015–1/31/2019 Clinical Research Award pluripotent stem cell-derived Conjugates Against Myeloma Role of Innate Immune Cells $20,000 GABAergic inhibitory neurons $200,000 Principal Investigator and Pathways in Ventilated $175,000 DNA 2.0 Inc, Lung Ischemia Reperfusion 2/5/2013–2/5/2018 $790,560 Hua Su Principal Investigator Martin London Improve the CHO Expression Anesthesia Dept, of a scFv Fragment that Principal Investigator 7/1/2013–6/30/2016 Principal Investigator is moving towards the James Ramsay NIH/NINDS, Anesthesia Department Anesthesia Dept, clinic optimizing the DNA 1/1/2014–12/31/2018 Research Award 7/1/2015–6/30/2016 Principal Investigator sequence of the scFv Hemodynamics of Cerebral $50,000 Anesthesia Department and/or leader sequence Tenax Therapeutics, Inc., Arteriovenous Malformations Research Award 5/15/2015–4/30/2020 $0 $1,633,785.65 $5,500 A Double-Blind, Randomized, Wan Zhu Placebo-Controlled Study of Principal Investigator Mervyn Maze Levosimendan in Patients NIH/NINDS, Principal Investigator Jennifer Lucero Principal Investigator with Left Ventricular Systolic 4/15/2014–3/31/2017 Hereditary Hemorrhagic Telanglectasia Foundation, Principal Investigator NIH/NIGMS, Dysfunction Undergoing Soluble VEGF Receptor 9/1/2013–8/31/2017 Cardiac Surgery Requiring Therapy for Brain 6/1/2015–9/30/2016 Anesthesia Dept, An Innovative Gene Therapy 7/1/2014–6/30/2016 Inflammation resolving Cardiopulmonary Bypass Arteriovenous Malformation mechanism dysregulation $206,097.08 $790,313 by Selective and Regulative Anesthesia Department Neutralizing VEGF in HHT Research Award in postoperative cognitive decline Principal Investigator Associated Brain $20,520 Jeffrey Sall NIH/NHLBI, Arteriovenous Malformation $1,212,399 1/16/2015–12/31/2018 Principal Investigator Principal Investigator $30,000 UCSF Academic Senate, Cell Type-Specific Influences Claus Niemann SmartTots, on HHT Pathogenesis 8/1/2015–1/31/2017 8/1/2013–6/30/2016 Intravenous Nitroglycerin for Principal Investigator Recognition memory following $1,582,037 Prevention of Hysterotomy Oregon Health & Science early childhood anesthesia University/Laura and Principal Investigator Extension During Cesarean $200,000 Michael Ryan Zodda Delivery in the Second Stage John Arnold Foundation, 1/1/2016–1/1/2019 Foundation, of Labor Principal Investigator 1/1/2013–Ongoing $29,321 Organ Donor Management NIH/NIGMS, Research Institute The Community Foundation 3/1/2015–2/29/2020 of Orange & Sullivan $2,782,000 Testosterone’s role in sex-specific outcomes $10,000 Jonathan Pan after early anesthesia Principal Investigator $1,524,496 Steven Takemoto FAER, 7/1/2014–6/30/2016 Principal Investigator Dexmedetomidine Renders Anesthesia Dept, Neuroprotection via Modula- 7/1/2014–6/30/16 tion of Systemic and Local Anesthesia Department Immune Responses Following Research Award Rodent Spinal Cord Injury $70,576 $175,000

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Spring 2016 | 22 Upcoming Events WARC 2016: April 29–May 1 The 54th Annual Western Anesthesia Residents Conference (WARC) will be hosted by Anesthesia the UCSF Department of Anesthesia and Perioperative Care from April 29 – May 1, 2016, at the Westin St. Francis Hotel in the Union Square area of San Francisco. This year’s conference promises to be both exciting and informative, with 19 News anesthesiology programs participating. is published by the UCSF As usual, the conference will include both oral and poster presentations authored Department of Anesthesia and Perioperative Care by participating residents, along with the 5th Annual Eger Lecture and a special closing banquet lecture. 500 Parnassus Avenue The Eger lecture will be presented by Dr. George Gregory who will discuss MUE 4th Floor, Box 0648 his 50 years of anesthesia practice at UCSF and around the world. We are particularly San Francisco, CA 94143-0648 excited about this lecture, as Dr. Gregory has spent much of his groundbreaking 415/476-4244 career here at UCSF Anesthesia and Perioperative Care, and it will be especially impressive to hear about all of the accomplishments that he has been a part of over http://anesthesia.ucsf.edu the past decades. Send all inquiries to The banquet lecture will be presented by Jesse Levinson, PhD, who is the UCSFAnesthesiaNews Co-Founder and CTO of Zooks, a venture-backed startup seeking to redefine @ucsf.edu transportation by creating ground-up, fully autonomous vehicles for point-to-point mobility in cities. For more information about WARC 2016, we invite you to visit the WARC 2016 DEPARTMENT CHAIR website: http://anesthesia.ucsf.edu/warc/. AND EDITOR-IN-CHIEF: Michael Gropper, MD, PhD The 2017 WARC meeting will be hosted by Oregon Health & Science University.

EDITOR: Morgen Ahearn AUA 2016: May 19–20

PRINCIPAL WRITER: The 63rd Annual Association of University Anesthesiologists meeting will be hosted Andrew Schwartz by the UCSF Department of Anesthesia and Perioperative Care from May 19–20, 2016. The host program has adopted the theme of the UCSF campus, which is precision DESIGNER: medicine. Although it’s tempting to think of precision medicine as a laboratory Laura Myers Design endeavor, we take a much broader view. At UCSF, we are driven by the idea that when the best research, the best teaching, and the best patient care converge, we can PHOTOGRAPHERS: deliver breakthroughs that help heal the world. Adam Jacobson The host program will highlight our Although it’s tempting to Arthur E. Guedel Anesthesia leadership in a number of important areas: Collection. Archives and basic laboratory discovery, translational think of precision medicine Special Collections, University research in neurosciences, cutting-edge as a laboratory endeavor, we of California, San Francisco care of the underserved with HIV/AIDS, and importantly, our strong commitment to take a much broader view. Marco Sanchez (UCSF building a workforce that represents the Documents, Media and Mail) incredible diversity of the San Francisco Bay Area and California. The sessions Richard Schlobohm promise to be both enlightening and entertaining. Christophe Wu In addition to this robust program focused on cutting-edge topics, we’re excited to (Sard Verbinnen & Co.) hold our May 19 social event at the California Academy of Sciences, “an aquarium, ©2016 The Regents of the planetarium and natural history museum – all under one living roof.” University of California Finally, San Francisco’s unparalleled cultural diversity has underpinned our department’s storied history of innovation in anesthesia, critical care, and pain medicine since its inception in 1958. We invite you to explore each of San Francisco’s distinct and charming neighborhoods. We are enormously proud of our department, our university, and our city, and look forward to sharing them with you. n

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