Januuy 9, 1990 Yol. XUJ No. I 'The Second U.S. Departnxn1 af Health Beat Thing and Human Senicea A&.utPayda.y"

Natiomd. lmtitllta of Heahh Recorid Human Genome Office Attains Center Status By l.eslie Fink

NIH's role in the human genome project, when it was formally ei;rablished by 11t:Cretary the worldwide effort ro sort and characterize of health and human se.rvkes Dr. Louis Sul­ the body's entire set of genetic instructions, livan. As an independent center, NCHGR took on new emphasis recently when a sepa­ will n:ceive di.reedy from Congress monies ear­ rate NIH center was established to fund and marked for human genome research which, oversee the work. The new National Center this year, will be about $60 million. The for Human Genome Research (NCHGR), for­ NCHGR ll1 also equivalent to other NIH merly the Office of Human Genome Research instirures in its role in advising the NIH under the NIH din:ctor, will now be equiv­ director on matters relating to the center's alent to other NIH institutes in its authority mission. In addition to being the focus within to award grants and plan and direct scientific NIH for usues relating to human genome research. .research, NCHGR works with other federal Directed by Dr. James D. Watson, the new agencies to coordinate, plan and develop pol­ center will distribute funds for research aimed icy on this project. Pnsidmt •mi Mt:i. 811Sh 11uitri the Clir1ital Cen­ at locating---and then analy:i:ing the chemical NOIGR currently has a staff of about 30 ur DK. 22 to wiJh NIH tmplr,ytt1 and patimtJ structure of. all the genes on the 23 pain of employees and expects to raise that number ht.,ppy hoJidayJ. The [mt /11,,,;/y flisitri a• •

DONOR MONTH Lecture Series on Taxes

(Continued from Page 1. ) Tax rime is scary enough for Americans; ir can be a nightmare for foreigners working in divided into componcnrs and the patient can the U nited Scares. be given only rhe pare he or she really needs. The Fogarty International Center's Interna­ One blood donation could save three or four tional Services and Communications B ranch is lives. However, this information should nor hosting a free lecture series ro help foreign sci­ leave the impression char the blood supply is entists unravel the U.S. rax system. overflowing. Just the opposire is true. Less The series of ninr sessions will begin J an. rhan 5 percent of che eligible popularion of 12 and run through Apr. 6. The locations and rhe Un iced Scates donates blooJ. New donors time vary. The cal ks will cover federal and are conscancly being soughr. scare annual rerurns, as well as such special This month, the NIH blood bank honors issues as tax crcary benefits. the thousands of donors who have supported The series is open to NIH Visiting Program Clinical Center patients and NIH research Dr. Harry V. Gelboi11. chief of 1he L,1bom1ory of participants, nonimmigrant guest researchers needs. Everyone who has thought of g iving Molec11lar Ca1'Ci11ogenesis , NCJ. /msmted 111•0 hon­ and special volunteers, nonimmigrants on blood is urged co scare out rhe nineties by orary !ec111mhip1 011 a recent trip to japan. He expert or expert consultant appointments, FIC donaring chis month. For more informarion, gave the Nakaso11e Lect11re at the National Cancer scholars-in-residence, flC incernarional or to make an appointment, please call Cemer Resea,rh Jmti111te in Tokyo. spomored by the research fellows and ocher nonimmig ranc sci­ 496-1048. Fo1111datio11 for P,-omotion of Cancer Resem·<'h. 1-le entists working officially at the NIH. The NIH blood bank is ntrrcnd y located in then tn;ve/ed to Sendai 10 present ,m honorary lec­ The ISCB also offers free, private rax con­ temporary quarters on rhe fifth floor of Bldg. t11re jointly sponsored by !he Fo11nda1io11 of Te1hoko su]cacions for NJH foreig n scientists. T he tax I0's D wing. le will move co permanent quar­ Medical S()(iety. The lectures are part of a series of consultant will nor prepare forms, bur will ters on the hospital's new first floor wing am111al prese111atio11s spomored by the fo1111datio11.s i11 advise scienrisrs abom problems and soon ; look for an announcement in the ncog11itio11 of i11divid11al excellence in ca11ce,­ procedures. Record. D t'eSl!Llt'Ch . Check with your intramural administrative office for a copy of the lecture schedule. for more derails about the lecrures, call 496-7357; to sched ule a consulranr appointment, phone KING 496-6166. D

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Yomh Chorale Alumni C horus will provide musical selections. Edward J ackson, currently director of the D.C. Youth Chorale at the The NIH Record Duke Ellington School of the Arts in W ash­ Pub lished biweekly at Bethesda, Md .. by the Edirorial ington, D.C. , and a voice instructor, will Oix·rarions Brauch, Division of Publi( lnfonnation, fur [he direct the alumni chorus. informar1on of employees of the National li,stitutes of This program is sponsored by the N IH Hcal1h, Departmenr of Health and H uman Services, and Divis ion of Equal Opporrunicy and irs I 990 circulated co nonemp loyees by subscriprion onli• through MLK planning commicree. Sign language th<-' Governmc:nc Priming Office. The conceo( is reprinrable interpretacion will be provided. For further without permission. Pictures nu)' be 3vai1ab1e on rf:<1uest. Dr. Pumell W. Choppi11 (r), president of 1he information or if accommodations for dis­ Use of funds for printing rhis pcr1odic.i l has lx:cn approved Howard l-l11ghes 1\llediral lmtitute, visits wilh Or. abilities are needed, please contact Denise by the director of rhe Office nf Managemeor and Budget Abne,- Notkim, chairman of 1he NIH A/11m12i t hrough September 30, 1990. Banks or Irene Peyron in the Division of Ass()(iatiw organizing roim11ittee. before a rere111 Equal Opport unicy, 496-610 I. n NIH Record Office Staff Correspondcncs: N IHAA 111eeli11g at the Cloister. Choppi11 reported Bldg. , I, Room 28 -03 CC. Ellyn Pollack Iha/ HHM/ will spend JOme $264 million in Phone 496-2125 OCRT, Chrisrine Pennella / 990 to wf,port 200 investigators and I , 600 mp­ DRC, Sue Meadows po,·t staff al 44 sileS across 1he U11ited States. Editor DRR , Michael Fluharty Clinic Needs Caregivers Rilhard McManus DRS. Jim Doherry 1-11-IMI is the nation's lm-ges/ 11011govern111e111al s11p­ FIC, Louise \\\'illian,s Th90

Michael Brown To Lecture on Genes and Cholesterol STEP Science Series Continues Nobel laureate Dr. Michael S. Brown will The second lccrure in the 1989-90 STEP be rhe fearnrcd speaker for rhe NIH Lecrure, "Science for All" series is scheduled for Jan. 17, at 3 p.m., in Masur Audirorium, Wednesday, Jan. 24 from I ro 3 p.m. Bldg. lO. "Genes Thar Control Cholesterol" is Entitled "Sex Hormones in Men and the tide of his ralk, sponsored by NHLBJ's Women," the talk will be presented in Division of Intramural Research. Wilson Hall, Bldg. I . Director of the Center for Generic Disease What are the signals char cause puberty and at the University of Texas Southwestern Medi­ how are they rimed) What are pheromones, cal Center, Brown is one of the seminal and arc they d istinctly male or female? How figures in cholesterol research . Wirh his col­ does an (asexual) ferus develop into a male or league Dr. Joseph Goldsrein, he discovered female? What mistakes during embryological the receptors char control rhc level of cho­ development create hermaphrodites? How do lesterol in blood. For this fundamental fertility drugs work and why do rhey cause advance, Brown and Goldstein shared rhe multiple births) fs premenstrual syndrome a Nobel Prize in Physiology or Medicine in biological fact or fallacy) ls male menopause a Dr. Michael S. Brown 1985, as well as many more honors including fuct or a myth? Why is baldness associated the Lasker Award and rhe National Medal of with high testosterone levels? H ow can Science. of che research chat earned Brown and Gold­ estrogen replacemenc therapy be harmful? A researcher and teacher at the University stein high honors. T hese and other questions about sex hor­ of Texas Southwestern Medical School in Brown received his B.A. and M.D. degrees mones will be answered by D r. Florence Dallas since 1971, Brown is now Paul J. from rhe University of Pennsylvania, and is Haseltine, who is board certified in obstetrics Thomas professor of medicine and generics, now a trustee of char school. A member of rhe a nd gynecology and in reproductive endo­ and holds the distinguished chair in biomedi­ National Academy of Sciences and che crinology. She is direcror of the Cenrer for cal sciences. Before starting his academic lnscirure of Medicine, he holds honorary Population Research, NJCHD, which is career in Texas, he spent 3 years as a degrees from the Universiry of Chicago, rhe responsible for the primary federal effort in the researcher at N IH. One of his former University of Pennsylvania, and l 'Universicc reproduccive sciences. institutes, NHLBl, has since supported much de Paris-Sud. D All are invited to attend chis evenr. For additional information, conracr the STEP pro­ g ram office, 496- 1493. D New Protein May Link Abnormal Development and Cancer Spread

Scientists at NCI have identified a novel In some patients whose cancers are detected i n fruit fly development, leading to death ar protein, N m23, which may be lost or reduced early, for example, the patients will be cured an early stage." The deformities include when cancer cells obtain rhe ability ro spread by surgery alone. But in a significant minor­ abnormal structure and differentiation of co distant sites in the body. Mouse and human ity, rhe disease will recur because microscopic numerous body parts. They are similar co rumor cells with a high cendency ro merascas­ deposits have spread rhroughour the body. lf changes seen during tumor progression and i1.e, or spread, have low levels of Nm23. ln docrors could identify parieors at high risk of spread-a process chat the researchers have conrrast, tumor cells char are less likely to recurrence, they could offer chose patients found to be associated with reduced levels of spread have high levels of rhe protein. The chemotherapy while sparing ocher paciencs the Nm23. scientists have also found chat Nm23 is almosr discomfort, risks and expense of additional "This is one of rhe first examples chat has identical co a protein char plays a crucial role rrearment. been found of a developmental gene chat is in fruit fly development. Genes furnish chc blueprints for making also associated with rumor metastasis," Liotta Dr. Patricia S. Steeg of NCJ's Laboratory of specific prorcins needed by a cell. From rhe noted. "The face that loss of the Nm23/Awd Parhology initially identified che m1123 gene, DNA sequence of che nm23 gene, rhe protein is associated both wich merascasis and which produces the Nm23 protein. She and researchers were able co predict the composi­ with developmental defects implies a molecu­ her coworkers reporred rheir findings in a tion of its corresponding protein. This lar link between these rwo processes. Deeper recent issue of Na1t,re. protein, they found, was 78 percent identical insight into chis connection could give us "Low levels of Nm23 protein correlated ro the predicted protein prodLICt of a recently clues char will help us understand and dC'al with ao increased tendency for rhe rumor cell reported fruic fly gene called awd (abnormal with cancer." D co spread," Sreeg said. "Since ir is rumor met­ wing discs). astasis, or spread, chat kills mosc cancer "The extraordinary degree of conservation of CC Departments Relocate patients, Nm2:3 protein levels could be impor­ r111123 during evolution from fruic fly co man tant cools for cancer prognosis and possibly suggests that chis gene may play a central role Two Clinical Center departmencs-spiricual rreatment. ·· in development," said Dr. Lance A. Liotta, ministry and parienc accivities-recenrly relo­ Dr. Ariella M. Rosengard, also of the Labo­ chief of the Laboratory of Pathology. "There's cated co space in what used co be sundecks on ratory of Pathology, explained rhac " the reason ro believe chat the role of Nm23 pro­ the hospital's 14th floor. The move put the Nm23 protein could aid in prognosis if ics tein in humans is similar ro che role played by cwo departments closer ro fac ilities ar rhe levels in pacienrs' rumors prove co correlate the Awd prorein in fruic flies." heart of each program- the hospital chapel in wich the development of recurrent cancer." Dr. Allen Shearn of Johns Hopkins Univer­ chc case of spiri rual ministry and the gym­ She added that "predicting the course of an sity, who studies the au•d gene, noted, nasium and assembly hall in the case of illness is imporranr to physicians because it "Mutations in rhe tltl'd gene, or decreased lev­ patient activities. Tours and refreshments helps rhem co selecr appropriate creacmenc. " els of its encoded prorein, cause abnormalities marked che opening of the new offices. 0 page 4 The Record January 9, 1990

GENOME (Continued from Page J ) human existence." The development of recombinant DNA technology in chc early seventies provided che basis for che techniques chat now allow scien­ ciscs co dcccrminc the order of chc uni cs, called bases, that make up DNA. DNA is the chemical substance genes arc made of. Even today, though, only che rclacively small and simple genomes of viruses have been fu lly sequenced. The genome of rhe cycomcgalovirus, for example, considered one of the largest virus genomes, contains about 240,000 bases organized into 22 genes. By comparison, chc large and complex human genome is estimated to contain about 3 billion bases, organized into some 100,000 genes. So far, the largest human gene to be sequenced directs rhe production of a protein Staff of the new National Center for Hm,um Genome Research includes (front. from I) Dr. Bettie Graham. known as human growth hormone and con­ Lit'.da Jacobw11, ~r. Elke Jordan. Michelle Coleman . JameJ Ve1111etti: (2nd rou•. from I) Sonya JackJoT/, tains abouc 70,000 bases. Al,re Thomas. Et·'.11 _Burgess, Carolyn Mohan; ( 3rd row, f,-0111 !) lva11 Hemandez, Linda Engel. Pam For several years, mapping and sequencing Lokken. Tmde Hdl,ard. Kathle.eT1 Howe; (back. from l) AT1ita Brooks . Dr. Nancy Pearson, Dr. Jane human genes has been carried out as a funda­ Peterson and K11111ar Vaswani. Missing from photo are NCH CR director Dr. J ames \VatJon, Dr. Mark rncnral scientific endeavor in laboratories Guyer. Leslie Fink, Jane Ades. Ma,jorie Bajefsky. Lolita Bm and ElaiT1e Leopold. around che world. The aim of che human genome project is co coordinate and focus NINDS Study Shows Parkinson's Disease Slowed by Deprenyl these individual efforts coward the common goal of determining che exact structure of the By Frances Taylor molecules of human heredity. Done randomly, The drug dcprenyl delays che progression of clinical trial ever conducted for Parkinson's says Watson, the projeer would take far too sympcoms in patients with early Parkinson's disease, LOO physicians and scientists studying long and would cost many rimes more than disease, according ro recent reports from a 800 patients created half rhe group with the $3 billion he escimares the unified project major NINOS-supported clinical study. deprcnyl and the other half wirh another will require. Parkinson's diseasc---a progressive, disabling experimental treatment or a placebo. During Knowing what human genes look like will brain disorder-afflicts more than 500,000 the first year of treatment, 44 percent of the open doors to understanding how chey work. Americans. patients not receiving deprenyl declined co the Knowledge about gene function will, it is Stud>' coordinator Dr. Ira Shoulson of the point of needing levodopa to maintain their hoped, lead ro new ways ro identify and treat University of Rochester believes deprenyl is normal daily activities. But over the same many of rhe thousands of known human dis­ the first rreatment ro slow rhe progress of a period, only 24 percent of the patients given eases caused by defective genes. The degenerative neurological disorder. "Our cur­ deprenyl required levodopa. information may also help researchers and doc­ rent data suggest," he and his colleagues "The results translate into a delay in the rors understand and treac ocher conditions reported, "that deprenyl .. . may delay the development of disability of nearly one year," such as cancer, heart disease and diabetes chat onset of severe disability by ameliorating an the scientists wrote, "and an extended capacity seem co run in families. underlying process of Parkinson's disease." for full-time employment." In face, rhe results ln the first phase of the project, scientists The clinical trial thus far has also demon­ were so promising chat che sciencisrs modified will begin a coordinated cask of mapping each strated char parients raking deprenyl are able the scudy to place all 800 pacienrs on deprenyl of the human chromosomes. This involves ro continue working full-time longer because therapy in order ro investigate the long-term breaking down the DNA in each chromosome deprenyl delays disability. benefits of rhe treatment. 0 · into manageable pieces and identifying chc Parkinson's patients experience tremor, stiff­ proper position of each piece on the chromo­ ness and loss of voluntary muscle control as some. In rhe process, many of rhe 100,000 Normal Volunteers Needed cells in the brain's substantia nigra die. human genes will be identified. This phase is Because these cells produce rhe chemical mes­ The Developmental Endocrinology Branch, expected co cake abouc 5 years. senger dopamine, their loss disrupts NICHD, is recruiting healrhy women as well During chis time, biologists, compucer sci­ movement-related communication in the as infertile women for clinical research studies. entists, engineers and chemists will develop brain. Candidates must be 18-50 years old and have new technolog ies chat will enable chem co The current therapy for Parkinson's dis­ regular menstrual cycles. They should not be break down and analyze the order of chc DNA easc--levodopa- bolsrers dopamine levels but currently taking chronic medication, including bases at a lower cost and greater speed than is docs nor scop eel I death. Because levodopa birrh control pills. now possible. This process, called gene alleviates Parkinson's symptoms without slow­ Srudies lase for one menstrual cycle and sequencing, will make up the second phase of ing the neuronal destruction that causes chem require frequent blood drawing and an endo­ rhc project and is expected co rake about 15 its effectiveness in many patients declines witl1 merrial biopsy. Compensation is available. for years to complete. nme. further information, call 496-4244. 0 In the dcprenyl stud>•, which is the largest pa~e 5 The Record January '), 199()

Management Intern Program Offers Career Opportunities MARC Meeting Draws Scholars The lGMS Minority Access to Research Are you i nrerested in management careers and selecrion process is provided at the ses­ Careers (.MARC) Program recently sponsored in aclministrative services, budget, grams anJ sions listed below. All sessions arc held from its eighth 1'>'1ARC scholars conference and pro­ contracts, personnel, program planning or 11 a.m. co noon except where noted by the g ram directors meeting at the Bethesda Hyatt public information? asterisk. Interested persons are cncourageJ co Regency Hotel. More than 1, 1.00 individuals The NIH Management Intern Prog ram attend one of the information sessions li sted attended, including 425 MARC srndcnts from (MlP) has trained individuals demonstrating below before completing the application. colleges and universities with substantial high potential for these careers and others and Dare l.ocatwn minoriry enrollments. is now accepting applications for rhe FY 90 Jan. 16 10// Ith fl. 1olari11111 T he conference was used as a forum co program. Past interns have come from a vari­ Jan. 17 3 l!Co11f Rw. JO enhance communications among MARC ety of backg rounds such as nursing, support Jan. 18 GRCIJ -117 trainees, prog ram direccors and NIH staff. staff, biology and chemistry. Baltimore. Md. The program provides specialized training J,w . 19 Federa/181-19 for selected individuals to prepare them for Jan. 22 Parkla11'11/Co11/ Rm. H careers at NIH. The program permits 12 to *Jan. 23 l0/9S235 l5 months of rorarional job assignments, (5-6 p. m.) which introduce interns co a variety of careers Ja11. 24 EPNIAB in administrative management. Experience is Jan. 25 HHS Bldg./703A supplemented by formal and informal train­ }tm. 26 36//B13 ing. Upon completion of the MIP, interns are For more information, call the NIH Train­ qualified for positions such as administrative ing Center, 496-621 1. 0 officer, budget analyst, grants management specialist and personnel management special­ ise. Graduates have been and continue to be a Science Teachers Needed primary source of furnre senior managers at NIH. A few good instructors are needed co reach Application forms are availabk now in the college level and graduate courses related to NIH Training Center, Bldg. 3 L, Rm. B2C29. biology and generics in the FAES Graduate S111dents mpported by the N IG1,1S Minority Access Applications muse be completed and received School. to Research Ct11·eers Pro!{ra111 listen to Dr. J ohn by Feb. 28. Course work is in biology, cell biology, Inman, chief uf the bioorganic rhe111i111-y section of To be eligible to apply, individuals must botany, developmental biology, cellular phys­ the NIAID Laborato,-y of lm11111110/ogy. dismss his have a career or career conditional appoint­ iology, neurobiology, microbiology, microbial research. ment; be a DHHS employee; be willing to genetics, microbial development, yeast work full time; and be at lease a GS-5 level genetics, drosophila genetics, human generics, During the 3-day meeting, minority students employee (positions are offered at the GS-5, 7, population genetics. biological signaling, who plan careers in biomedical research heard and 9 levels; employees above the GS-9 level molecular biology, generic engineering, presentations by leading scientists. The stu­ may be eligible co cake a down g rade bur molecular evolution, ere. dents also held poster sessions and gave oral retain t heir salary). Please contact Michael Cashel, presentations on their research in such areas as Information on the program, application 496-0619. D eel I biology, immunology, physiology, micro­ biology, psychology, genetics and pharmacology. One of the meerings's highlights came when HHS secretary Dr. Louis W. Sullivan addressed the attendees during a seminar held ar NIH. Following the seminar, the MARC students toured 43 NIH laboratories tO learn about research in progress. Also participating in the events chat day were a number of scu­ dems from Washingcon area high schools. The MARC program is administered by N lGMS in collaboracion with other NlH institutes. One of the program's goals is co strengthen science curricula and research opportunities at institutions with substantial minority enrollment in order ro prepare sru­ dents for careers in biomedical research. Toward this end, rhc institute offers through MARC underg raduate research training grants The 1989 graduating elem of presitk11tial managemefll interm and NIH 111anage111e11t interns are pirt11red for students in their third and fourth years of with NIH aJJociate di.-ector for ad111i11istmtio11 J ohn D. Mahoney /sta11di11g, c/. They are: (standing. I lo r) college to prepare them to compete suc­ Mark Kavlick. Jane Daye. Pamela Lokken. Kathleen Lively and Ann Elizabeth D11ane. Seated are (from cessfully for entry inco g raduate prog rams /) \lfrf!,i11ia DeSea11. Abby Baum and Carole Kirby . Not pict11red (tre Leslie Newso111e and Gi11nie Kiesewet­ leading to Ph.D. degrees in the biomedical /et·. Recruitment for the 1990-199 1 NIH Manaf!.ement Intern Program began.fall. 8. sciences. D page 6 The Record Janu;:1ry 9, 1990

Fauci Receives 'Flame of Hope' Award from Lupus Institute Mineo Named to NIEHS Grants Post Dr. Anthony S. Fauci, director of chc David L. Mineo has been named chief of National Institute of Allergy and Infectious the Grants Management Branch within che Diseases, was recently honored by che Terri Division of Extramural Research and T raining, Gocrhclf Lupus Research lnstiture with rhe NlEHS. annual Flame of Hope Award for his "contri­ He will be responsible for adminiscracion of butions ro basic and clinical research on rhe more than 300 active extramural grants co immune system." The ceremony cook place in universities and other nonprofit rese;i.rch insci­ rhe C1pirol Hill office of Congressman cucions rhroughouc rhe United Scares. These Christopher Shays (R-Conn.}. include individual research grants, cencer Theodore Gotthelf, chairman of rhe board grants co Environmental Health Sciences Cen­ of cruscees for che Lupus Research lnsritute, ters and Marine and Freshwater Biomedical said, " We honor Dr. Fauci for his ongoing Research Centers, as well as craini ng grants. leadership in immune research. His work in Mineo comes to NlEHS from its sister lupus research has been invaluable, not only in institute in NIH, the National Institute of undersrnnding lupus as ic relates ro the Neurological Disorders and Stroke, where he immune system, buc also in laying che foun­ was chief of che Granes Management Branch. dation for new crearments of chese complicated He is a graduate of American University in diseases." business administrarion. 0 Gotthelf who went on co noce chat Fauci NJAJD dirmor Dr. A111ho11y S. F,111.-i (/) receives has become a national and international the amwal l'Lt1111e of J-1,;pe J\u-ard fro111 Theodore Banner Joins NIA Neurosciences spokesman on AIDS research and potential Go11helf. ,hair111an of the b11ard of lmste/!J of the treatments, continued, "Dr. Fauci's earlier Terri Gotthelf L11p11J Rma,·,-h hmi1111e. Dr. Carl Banner has joined che neuroscience work with lupus research and rhe regulation of and neuropsychology of aging program ac the rhe immune system prepared him for the enor­ lupus and irs symptoms. The insticure's major · National Tnscicuce on Aging as a health scien­ mous challenge he now faces." focus is sponsorship of the lupus scholar tist adminisrracor. He was previously a senior {n accepting the award, Fauci said, " l am . research program, which supports young scien­ staff fellow in the Laboratory of Molecular honored co be selected for chis award. The tists under che supervision of senior Biology ac NINOS. study of lupus has probably shed more light invescigacors for 3-year periods ac research Ac N IA, Banner will direct the extramural on che complexities of immune function and facilities throughout che councry. The goal is research program on che etiology of g iven us more insight inco a vase array of dis­ ro create a cadre of individuals who will pur­ Alzheimer's disease. He said he considers this eases than any other single disease. Efforts of a sue lupus research as a career. a parricularly exciring rime co be working in number of investigacors in lupus research have The institute is named for rhe late Terri chis field. Molecular biolog.iscs have made sig­ been beneficial nor only for lupus paciencs, Gotthelf, who died of lupus ac che age of 21 nificant progress in characterizing the bur also for all mankind in undersranding one in 1981. She and her father, Theodore, neuropachological markers that accompany chis of che most imporcaoc systems of che body­ decided co escabl ish rhe Terri Gotthelf Lupus severe form of dementia. In addition. recent rhe immune syscem. " Research Inscicuce co help ochers learn more advances have been made in fi nding a generic The Lupus Research lnsc iruce·s mission is co abouc the disease and find its cause and locus associated with a familial form of increase public awareness and knowledge of cure. 0 Alzheimer's disease. Banner received his Ph .D. in cellular and Workshop on Monkey Behavior developmental biology from Harvard Univer­ A workshop on " Monkey Behavior and Lab­ sit y in 1983. 0 oracocy Issues" will be held Friday, Jan. 26, 8 a. m . co 4 :30 p.m. in Lister Hill ALtdicorium, Furniture Donations Sought Bldg . 38A. Discussion will focus on behavioral and Help give foreig n scientists a leg up--a social needs of nonhuman primates in relation chair or cable leg, chat is. The Fogarty Inter­ ro their well-being, and oprimal methods of nacional Ceocer needs furniture co loan co conducting biomedical research with primates. some of che 2,000 foreign scientists carrying W orkshop leaders will be Dr. Melinda our research on campus. Novak, University of Massachusetts and New The loans are handled by the FIC's Foreig n England Regional Primate Research Center, Scientisc Furniture Loan Service (FSFLS), and Dr. William Mason, University of Cal­ which relies solely on private donations. Cur­ ifornia, Davis, and California Regional rently, the service has a severe shortage of Pri mace Research Cenccr. Faculty are pri­ such items as beds and bedding, tables, matology experts from various research chairs, kitchen supplies, sofas, dressers and The NIH ToaJtmasters Club, 1w111 in itJ 20th yea,· inscicucions. bookcases. on ca111f111J, recently elected new officers f (JY the Jim The workshop is open co N IH intramural Donations are rax-deductible. T hey pay 6 monthJ of 1990. They are (from I) Lollise scientists, facility managers, veterinarians, another dividend, too-chey give donors a McHugh, secreta,.y; Janice Andenon. sergeant-at­ technicians and animal care staff working wich jump on rheir spring cleaning. Anyone incer­ anm; Jennie Himt. pre;ident; Ma,y Graham. monkeys. esced in donating usable goods should concacc admi11istrt1live vice pwidmt; Ann R1mo. treasurer. For more information, contact the Office of Helena Safarova, FSFLS manager, Bldg. 35, All a,-e welcome to ,lllend dub meeti11gJ held each Animal Care and Use, 496-5424. 0 Rm. B301, 496-63 18. 0 Friday in Bldg. 10. l?m. 2C210. page 7 The Record January 9. 1990

Lockshin Named NIAMS Extramural Program Director Dr. Michae l D. Lockshin, an aurhoriry on Rhet1matology and is a reviewer for many ocher systemic lupus erythematosus, was recencly scientific journals, including the New England appointed director of che extramural prog ram Journal of Medicine and the J o11rnal of ar che National lnsticute of Arthritis and Mus­ Immunology. culoskeletal and Skin Diseases. A native of Ohio, Lock.shin received his As director of chis program, he will oversee undergraduate degree from Harvard College in the development, review and funding of grants 1959 and his medical degree from Harvard and conrracts for NIAMS. Lockshin will be Medical School in 1963. From 1963 co 1968, responsible for NIAMS's almost 800 active he served as an intern and then a resident at grants chat support a full range of basic scien­ Bellevue Hospital and Memorial Hospital for tific and clinical research. Additionally, he Cancer and Allied Diseases in New York City. will manage the institute's research centers in During chis period, he also served as an epi­ arthritis and m L1sCL1loskcletal and skin diseases demic intellig ence service officer ac the and its research training program, which Communicable Diseases Center in Atlanta and includes more than 200 fellowships, career assistant professor of epidemiology, University awards and institutional training awards. of Pittsburgh Graduate School of Public Lockshin will advise and participate with Health. From 1968 co l970, he served as a NLGMS director D,·. Ruth L. Kirsch.rtein ( I) pre­ the inscicure's national advisnry council in fellow in rheumatology at Columbia-Pres­ .rent., a certificate to Dr. Lucy Shapiro ( r) in byterian Medical Cenrer. recoj!,nition of her pre.relllation of the De\Vitt Ste/­ " As a former grantee of NlAMS, I have a ten, J r. Lecture. Shapiro. who is professor and strong feeling for rhe mission of rhe cht1irman of the department of developmental biology institute," Lockshin said. "My career to date al Stanford University School of Medicine, spoke 011 has bridged both the clinical and the research "The Comrol of Timing and Spatial O,-ganiza1io11 worlds, and I look forward co a new and excit­ During Cellular Differentiatio11. " In the renter is ing challenge as director of chc NIAMS S1et1e11. who is NIH deputy director for sdmce. extramural program. "-Barbara A. Weldon 0 e111erit11s.

Lee Appointed Chief of N/CHD's Biometry And Mathematical Statistics Branch Dr. Young Jack Lee has been appointed chief of che Biometry and Mathematical Scatis­ rics Branch in the Prevt:ntion Research Program of the National lnstirure of Child Dr. Michael Lockshin Health and Human Development. He began his appointment as chief in October after 9 identifying and assessing the needs and years as a mathematical statistician in the requirements for research and manpower National Institute of Neurological Disorders development. In addition, he will advise the and Stroke. institute d irector on all matters and policies "As a branch chief, l am responsible for sec­ pertaining to the extramural program. ring rhe direction of the branch," Lee says. Before coming co NIAMS, Lockshin was "My goals are statistical excellence and respon­ professor of medicine ac Cornell University sible collaboration with ocher members of the Medical College; attending physician at the IOStltUte. New York Hospital; attending physician and A native of Korea, Lee came ro NIH in associate scientist at the H ospital for Special 1977 when he joined rhc National Cancer Dr. }'01111g J ack Lee Surgery and a consultant in rheumarology at Institute as an IPA from the University of Memorial H ospital Sloan- Kettering Cancer Maryland. From 1977 to 1979, he designed Center. and reviewed clinical trial protocols, as well as cognition in children. Author of more than 70 scientific papers analyzed data, for NCI. l n l979, Lee was Lee obtained his B.S.E.E. degree from and book chaprers, Lockshin has received appointed scaristician in NCJ's Carcinogenesis Seoul National University's College of Eng i­ numerous honors for his work in the area of Testing Program, where he remained until neering. He has M.S. and Ph.D. dt:grees in systemic lupus erythemacosus. He has served 1980. statistics from Ohio Scare University. on numerous committees of the American Col­ From 1980 co the present, Lee served as a Lee is activt: in sevt:ral professional societies, lege of Rheumatology, the Arthritis mathematical statistician in NINOS. In addi­ including the American Statistical Association, Foundation and the Lupus FoL!Ildation of tion to performing scatiscical consulcarion and rhe Biometric Society and the Society for America. From 1983 co I 986, Lockshin was a collaborarion for the i nsci tute's projects, he Clinical Trials. He has published numerous member of rhe board of directors of the Amer­ conducted research in statistical methodology articles on both statistics and biostaristics, as ican Board of Internal Medicine and chairman and escablisht:d and operated a scac iscical coor­ well as ocher subjects. H e is an edirorial board of its subcommittee on rheumatology. Ac che dinating center. While at NINOS, Lee also member of the America11 Jom·nal of Mathemati­ present time, he serves on the editorial boards worked on a project studying the long-term cal and Management Sciences and a rcviewt:r for of Arthritis and Rhe11111atism and the jo1J.rnal of effects of the anciconvulsant phenobarbital on the Mathematical Review.-Anne Blank 0 page 8 The Record January 9, 1990

Lecture/Film Series Focuses on Stress The NIH Employee Counseling Services Film: The Slender Trap will continue its 1989/ 1990 Guest Lecture Wednesday, May 23. Little Theater. Bldg. JO. Series chrough July 1990. The t heme of the series is ''Stress Passages: Surviving Life June Co-Dependwcy: When Helping You ls Hurting Me Changes in Turbulent Times." J\ndreu, Sp,11·ber. R.N. A combination of seven lecture presenta­ \Vednesdfly, June 20 , \flilso11 Hall, Bldg. 1. tions and seven films will be presemed on the NIH campus. Each lecture and fi lm presenra­ Film: It's Your Prob/e,n tion will be offered in rhe same rime period­ Wednesday, June 27, Little Thwer, Bldg. IO. noon co I p. m.- throughout the series. The purpose of the series is co provide information July co the NIH community on the effects of rapid The Good News About Depression A smoky fire Dec. 7 in the basement of Bldg. 5 social change and transition on the individual, Nomum Wilson . M .D. drew fire fighters fi'om N IH and foJ1r other com­ che family and the workplace. \Vednestlay, July 1 l, Wilson Hall. Bldg. I. panies but was q11ickly extinguiJhed. The blaze Each month a prescncarion followed by a Film: Dealing With Depression began 011 the B3 level when sparks from a welder's question and answer session will be led by an \flednesday . July 18, Little Theater. Bldg. torch ignited materials in a storage area. No i11j11- expert in rhe field focus ing on various aspects JO . 0 1·ies occurred and 110 damage was ,·eported since the of our Jives in transition. On rhe week follow­ b11ilt!ing is mn-ently ,mt!ergoing co111plete ing che lecture, a fi lm on the copic and a Yef/Ol!fllion. small group discussion will be offered. The schedule for the lectures and film presentations is listed below. NIH Communicators Collect Kudos from NAGC January Beyond G.-ief: Renewal Strategies far Dealing With NIH's public information community col­ Nancy Brun collecred third place for her LoJJ Jecced colorful kudos recently; rhe National "N ational Cancer lnstitute 1989 Nutrition Elizabeth Kobren. R.N., M.A . Association of Government Comrnunicacors Calendar/Poster Series" in the visual design T11esday . Jt1n. 16. Wilson Hflll, Bldg. 1. (NAGC) recently announced t he 1989 winners category. in the largest ever of irs annual Gold Screen The Clinical Center claimed two Blue Pen­ Film: The Ameche Family and Blue Pencil compecicion. cils and a Gold Screen: \f/ednesday, Jan. 24, Little Theater, Bid!(. 10. More than 700 entries nationwide vied for Medicine fo r the Layman - Relieving Pain, February che Blue Pencil honors chat NAGC gives co Stroke Update, Alzheinm·'s Disease, by Irene Coping \flith Diversity: The Black Experience outsranding publications. The promise of a Haske, Mary Hepburn and Ellyn Pollack, won Arthur f-Jendenon, M.D. Gold Screen prize, awarded for oucscanding first place for best one-color general audience \ffednesd"Y· Feb. 14, Lipsett Amphitheater, Bldg. audiovisual materials, drew more than 150 publicarion. 10. competitots. N IH winners and cities of their Wendy Schubert of che CC cook second work are listed below. place for her one-color technical audience pub­ Fil11t: Legacy of a Dream The National Cancer Institute captured nine lication, C11ltJ1ral lnflumces on Health Ca,·e. Wednesday, Feb. 21 , Little Theater, Bldg. IO. Blue Pencil Awards: " PORTACATH: Patient Information," a Chew 01· Sn11ff iJ Real Bad StJJjf, a brochure videotape by Harriett Bennetr, formerly of rhe March submitted by Paul Van N evel, won honorable CC, received honorable mention in its J oining Forces: Balancing 0111 \f/o,·k and Family Demands mention in rhe category for best four-color category. general brnchure. Other NIH awardees included Mary Sul­ Michael Stadte,·. Ph.D. In rhc category for best rwo- or three-color livan of the Office of Communications, OD, Monday, Mai·. 79, Wi/Jon Hedi, Bldg. l. publication for a general audience, NCl's A whose News and Features /mm NIH- Special Film: Ai-hieving Balance: How to Handle the Time of Change/De Nina a /11uje,· woo second /ssue-\flomen's Health won third place in the Stress of Work and Famity Life place; Chris Thomsen won honorable mention caregory for one-color general audience pub­ Wednesday. Ma,. 28. Little Theater, Bldg. IO. for his What You N eed to Know About Cance.­ lications. senes. T he National Diaberes Information Clear­ April lo the category for best two- or three-color ingho,tse won thirJ place in the cwo- or three­ The Wo1111ded Family: Dealing With Family publication for a technical audience, NCJ's color general audience pubI icacioo category for Violence Advocacy Institute won first place for its The Diabetes Dirtiortmy, submitted by Beatrice Nancy Peme, M.S. W. !v1edia Strategier for Smoking Co111rol. Jakubowski of NIDDK. Thumkiy. A.p,·. 72 . \f/i/son Hall. Bldg. 1. Two honorable mencions- Q11it for Good Kit Editors Diane Srriar of NHLBl and Louise Film: T o A Safer Place and PatientJ Helping Progress: Cancer Clinical W illiams of FCC collaborated on the two- or Wednesday, Apr. I 8 , Little Theater. Bldg. 70. Trials Pres.r Kit-as well as second place Hou, three-color general audience honorable men­ To Help Yo,1r Patients Stop Smoking were tion, Develop111ent,t! Speech and l,,,:mg11age May awarded co NC! in the category for best four­ Dism-ders . When Food ls a Problem: Taking a Look at Eat­ color publicarioo for a technical audience. Award winners received rheir honors ar a ing Disordm "Bonanza Sweepstakes Bags Millions for banquet held recently at the Rosslyn Wescpark Sonja Lange Cancer Groups-How Much for Cancer?, .. a Hotel in Arlington.--Carla Garnett D Wed,1e1day, May 16. Wilson Hall. Bldg. I. feature story submitted by Kate Ruddon, won rhird place in its category. The Record Janu,,ry 'J. 1990

FIC Scholar Lauded for Scientific Achievements NCNR Funds Centers

By Louise \X1illian1s For Nursing Research

Dr. Viswanarhan Sasisekharan is having a NCNR granrs toraling more than SI . 3 mil­ good year. In facr, rhe Fogarry lnternarional lion have been awarded to schools of nursing Center scholar-in-residence is having several at four universities to develop explorawry or good years all at once. specialized cenrers for nursing research. The The Indian biophysicist has won three pres­ schools are: University of Minnesota, Univer­ tigious awards- two given anmtally for sity of Piccsburgh, University of Pennsylvania scientific achievement and a third honoring 40 and University of Washingron. years of accomplishment. A specialized research center grant was He received the Shri Orn Prnkash Bhasin awarded co Dr. Nancy F. Woods at the Uni­ Award for Science and Technology in the field versity of Washington School of N ursing in of biotechnology. Given by India's National Seattle co develop a Cenrer for Women's Academy of Sciences, the award prompted an Health Research. The 5-year grant will sup­ Indian newspaper to dub Sasisekharan and his port studies focusing on midlife issues: cowinners "the country's rop 10 scientists." symproms char may be associated with stress He also won the Jagdish Chandra Bose or reproductive hormone transition; rhe wan­ Award for research in the life sciences. The ing of fertility; recovery from alcohol and drug award commends achievement in such disci­ abuse; rhe effects of ovarian hormones on plines as the life, ph)rsical and chemical intestine function and sleep patterns with sciences. It is funded by a trust, run by the Dr. Viswa11atha11 Sasisekhatan exp/aim a model nf aging. Indian government's universiry grants commis­ sevenfold sym11tetrica! growth. Dr. Ruth McCorkle of rhe School of Nurs­ sion , which oversees institutions' funding and ing, University of Pennsylvania, has received a curricula. specialized research center grant for advancing Finally, Sasisekharan was chosen to ing. Prior to raking up his scholar's residency care in serious illness. The 5-year award will exemplify 40 years of achievement in Indian last April, the 56-year-old Sasisekharan served concern i rnproving recovery from surgery, science--an award honoring his country's as dean of the science faculty, chairman of the facilitating adaptation to cancer diagnosis, and statehood. The special honor was created by division of biological sciences, and professor of studying the health effects of bereavement. the Waturnull Foundation, an organization biophysics at rhe Jndian Institute of Science in A 3-year grant has been awarded to Dr. Sue based in Honolulu, Hawaii, that funds such Bangalore in southern India. K. Donaldson at the University of Minnesota public service projects as a reforestarion pro­ St ill , scientists do nor live by bread and School of Nursing co establish an explorarory gram in India. T he awards were given to one butter alone, and Sasisekbaran found his many center focusing on long-term care of the individual each from such disparate fields as administrative duties lefr roo lircle rime for elderly. Feasibility studies will concern alcohol science, spores and the arts. research. So, he accepted an invitation co rrearment for older persons, prevention of All rhree awards pay tribute to become a Fogarty scholar. falls, methods of discharge planning and issues Sasisekharan's investigations of the srructure­ He was nominated for the award by Drs. in family caregiving. function relationship in macromolecules. Per­ H. Todd Miles and David R. Davies, chiefs of Dr. Jacqueline M. Dunbar of the University haps most significant has been his work on the the sections of organic chemistry and molecu­ of Pittsburgh has received a 3-year award to conformations of proteins, the structure of lar structure, respectively, of the National esrablish a Cencer for Research in Critical Care nucleic acid and drug-deoxyribonucleic acid Institute of Diabetes and Digestive and Nursing. The exploratory cenrer granr will (DNA) interactions. Kidney Diseases. concern such issues as improved patient safety For example, he and colleagues have been Sasisekharan is the fourth Fogarty scholar during mechanical breaching, social support looking at anti tumor and anticancer drugs that from India, and he is finding the NJH "an and recovery, and causes of in jury in children. bind ro DNA. They have synthesized analogs ideal place" for getting back co full-time For further information, contact the NCNR of nacurally occurring molecules that appar­ research. Lately, his interesrs have drawn him Division of Extramural Programs, ently derive their biological acriviry from their inro marhemarical realms, specifically irra­ 496-0523. □ geometrical shapes, which curve co permit tional numbers and geometrical methods for DNA bonding. The investigators have syn­ generating aperiodic larrices, as be ponders thesized analogs of disramycin and netropsin, nature's seeming preference for certain symme­ Salute to Youth Dinner changing the curvature of the naturally occur­ tries and whether or nor noncrysralJographic Members of rhc NIH community are cor­ ring molecules' backbones. The synthesized symmetries can develop. dially invited to the 1990 Salute to Youth analogs are as roxic as their natural counter­ "T he NIH has afforded me rhe opportunity Dinner. This year·s honorees are the Honor­ parts and may ultimately prove therapeutically and freedom ro do what 1 wanr, and I don't able Constance A. and Mr. Anthony Morella. effective against some cancers. However, think l could enjoy ic more," he says. The event will rake place on Saturday, Jan. Sasisekharan stresses chat much more work lies He plans ro continue these studies on 27, at the Hyatt Regency Bethesda, wirh ahead and thar his investigations have dealt returning co Bangalore next spring, when he dancing ro Richard Bray"s Orchestra and din­ only with the drugs' physical chemistry-he resumes his professorship at the Indian ner. Festivities begin ar 7 p. rn. Tickers arc has not performed biological rests with them. Institute of Sciences. D $ 150 each; proceeds benefit Bethesda Youth Sasisekharan refers ro these investigations as Services programs for the prevenrion of sub­ his "bread and burrer" work, and they have stance abuse. Call Randy Schools, 496-606 I, brought him more than accolades. They also or Bob Caldwell, 530-3725, if you would like helped propel him co a high academic stand- ro have a formal invitation. D The Record J.1nuary 9. 1990

Marvin Cassman Named NIGMS Deputy Director NIGMS Director Kirschstein Honored Dr. Marvin Cassman was recently appoinred Dr. Ruth L. Kirschstein, NIGMS director, deputy director of NIGMS. Prior co chis was recently selected by the Office of Person­ assignment, he served as director of N IGMS' nel Management for irs 1989 " Profiles in Biophysics anJ Physiological Sciences Excellence," a pare of OPM's organizational Program. excellence project rhac was launched last year "Biomedical research is one of my cop pri­ ro identify, document and disseminate i nfor­ orities and Dr. Cassrnan's broad expertise in mation on outstanding leadership and such rapidly advancing areas as snucturaJ biol- organization practices in the federal ogy, biophysics and instrumentation . government . development make him eminently qualified for Kirschscein was cited for leadership char his new rosirion," said Dr. Louis W. Sul­ "esrablished an international reputation for rhe livan, HHS secretary. "In addition to his institute and built consensus and support in scientific proficiency, D r. Cassman possesses the scientific community and Congress." the administrative skills needed co manage Prior to becoming NIGMS director in research programs not only in such established 1974, Kirschsrein was an intramural scientist fields as genetics and cellular biology, but also who developed a test to ensure rhe safety of in biotechnology, structural biology and or her viral vaccines such as those used for polio, areas chat will concinue co grow in importance Dr. Mm-vin C,,u111tm in rhe 2 lsr cenrury." As deputy direcror, Cassman will aid the NIGMS direccor in executing policies, coordi­ rion. Cassman became direcror of the newly nating activiries and allocating the resources of created Biophysics and Physiological Sciences NIGMS. In addition, he will represent Program in 1985. NIGMS at NIH forums and in dealings with A native of Chicago, Cassman received his other agencies, outside scientific organizations B.A., B.Sc. and .M.S. degrees from the Uni­ and international scientific groups. versity of Chicago. He earned his Ph.D. in Cassman joined NlGMS as a healch scientist biochemistry from the Albert Einstein College administrator in 1975 and was appointed chief of Medicine, New York City, in 1965. After of the molecular basis of disease section in graduation he worked as postdocroral fellow at 1978. One of his accomplishments during rhis the University of California, Berkeley, follow­ period was the launching of a program to fund ing which he taught biochemistry and the purchase of scientific instruments char are biophysics at the University of California, shared among researchers ar a grantee institu- Santa Barbara.- Anne A. Oplinger 0 Dr. Ruth L. Kirschstein measles and rubella. As a result of her work Harald Loe Honored by Norwegian Government and chat of her staff, che "Sabin strains" were Dr. Harald Loe, director of the National selected as che safest for rhe oral polio vaccine, Institute of Deneal Research for rhe past 7 which virtually eliminated the incidence of years, was recently appointed Commander of polio in the United States. the Royal Norwegian Order of Merir by King "Profile" honorees may be federal executives Olav V of Norway. as well as organizations. Nine ocher 1989 win­ The Order of .Merit is presented to chose ners include the Centers for Disease Control, whose accomplishments furrher Norwegian the Social Security Administration and secre­ interests and international relations between tary of energy James D. Watkins. D Norway and other countries. Loe was recog­ Tickets on Sale at R&W nized for his excensive contributions ro his fielJ of Jcntal research bot!, in the United R&W has discounr tickers on sale now for States and his native country. rhe following upcoming Kennedy Center The tide of Commander of t he Royal Nor­ events: wegian Order of Merit was conferred upon Loe Feb. 17 - Beaux Arcs Trio, $20 at a ceremony in the Embassy of orway in Mar. 17 - Dance Thearre of Harlem, $29 Washington, D.C. The Norwegian ambas­ Dr. Harald Lo'e ( I) affe/JII King Olav V's honor Mar. 31 - American Ballet 50rh Anniver- sador, Kjdd Vibe, pre>ented him wirh a ,gold from Norwef!,ian ambassador Kjeld Vibe. sary Celebration, $.32 cross and a diploma citing rhe appreciation of Apr. 27 - National Symphony Orchestra, King Olav. lo his speech, Ambassador Vibe $22. 50 complimented Loe on his contribmions co chat bacteria in plaque cause gingiviris. Fur­ May 4 - Tokyo String Quarcet/WPAS, research and said, "Through his work, Dr. Liie ther research led him to the development of an $25.50 has also contributed cowards bringing our two experimemal mouth rinse char can reduce gin­ May 25 -. Pearl Bailey with Louis Bellson, narions closer tog ether," givitis- the first stage of gum disease. The $27 Loe is an i ncernationally renowned expert on mouth rinse is now used widely in Europe and Order your tickets at any R&W. For more perindonral disease. He was the first ro prove rhe U.S. 0 information call 496-4600. 0 page 11 The Record January 9, 1990

TRAINING TIPS Arthur Hand Retires from PHS Dental Career

The NIH Training Center of the Division Dr. Arthur R. Hand, a senior research served as acting chief of che Mineralized of Personnel Managemenr offers the following: investigacor with the National Institute of T issue Research Branch, and in 1982 he was Deneal Research , retired from rhe Public also named chief, laboracory of Oral Biology Co11rw rmd ProxramJ Dates Health Service Dec. L to become director of and Physiology. He joined the Clinical Inves­ the central electron microscope facility at the tigations and Patient Care Branch in 1986. Manaxement and S11pervisory 496-6371 Using Animal, in Intramural Research: University of Connecticut Health Center at "I chink what I'll miss most are my col­ Guidelines for lnvescigaro" 1111 Farmington. He will also hold a faculty leagues at NIDR. le is very apparenc here chat Federal Budget Process I/ 17 appcincmcnt in the university's department of you can ask for help and get it," said Hand. How to Write and Publish Sciencific pediacric dcnrisrry. Hand currently conduces Hand accended the school of dentistry at the Papers 1/23 Creative Basics for Changing Workplaces 1125 research on salivary gland structure and func­ University of California ac Los Angeles on a Good Scares: Transition Planning 2/2 tion in NIDR's Clinical Investigations and regents scholarship and graduated summa cum Working W irh Personal Differences laude. He received a PHS Commendation MBTI II 21 14 Medal in 1975 and the Basic Research in Oral Office Operations Training 496-6211 Science Award from the lnrcrnacional Associa­ tion for Denral Research i[l 1978 Introduction co Working ac NI_H for Hand hopes co continue his research on sali­ New Support Scaff 1/22 Office Managemem for Secretaries 1122 vary glands at the U niversicy of Delegated Acquisition 1/29 Connecticuc.-Mary Daum D Training and Development Services 496-6211 Personal Compuu:r training is avaih1ble through User Healing Human Hearts Resources Center (URC) self scudy courses. There is no Dr. Susan R. Gorcner, professor of nursing cosc co NIH employees for these hands-on sessaons. The U RC hours are: and director of the cardiac recovery laboratory Monday 8:30 a.m. - 7 p.m. ac the School of Nursing, University of Cal­ Tues. Wed. Thurs. 8:30 a.m. - 7 p.m. ifornia, San Francisco, will address recovery Friday ll:30 a.m. - 4:30 p.m. from heart surgery in the third NCNR dis­ Saturday 9 ,1.m. - 1 p.m. tinguished scholar seminar on Thursday, Jan. Training Center, DCRT, and ocher training 25 at 7 p.m. The seminar will cake place in information is available on WYLBUR. Logon the Mary Woodard Lasker Center for Health co WYLBUR and type ENTER TRAINING. Research and Educarion (the Cloister). In her presencacion, entitled "Healing Human Hearts," Gorrner will discuss the Dr. Arthur Hand

Patienr Care Branch. He has been with PHS and NIDR for more chan 20 years. "I think of the move as more of a career change than a retirement," said Hand. "When this opportunity came up I decided it would be a good time to retire from the PHS and take on a new challenge." Pare of his responsibilicy at rhe university will be to design and teach a graduate course on eleccron microscopy. "I especially am look­ ing forward co teaching. What little teaching I've done in the lase 20 ye-ars I've really enjoyed," he said. Hand joined NIDR in 1968 as a research investigator in rhe Laboracory of Biological Structure (LBS). He worked in chat capacity Dr. S11Sa11 R. Gn,-tner until 1976, when he traveled to McGill Uni­ NCI director Dr. Samml Broder ( I) aca:pts 1he versity in Montreal co serve as a visiting social. emotional, educational and fami ly Toastmasters lntemational C01m111mil'ation Achieve­ professor there for l year. issues relating co recovery from heart surgery. ment a11d Leadership award from D,·. Padman "The year as visi ring professor was very The event is cosponsored by NHLBI. Sarm,1 of 1he NIH Toastmasters Club. The amll(a/ enjoyable. l Learned a great deal. le was a Goerner will also discuss her research on the a111ard honors NJH'ers who don't belong to the c/11/; good oppcrcunicy and I would recommend reasons people elect heart surgery; whether or b11t who de111011Jtrate 0Ntsta11ding ability to cof/111111- chac experience for anyone who is offered chat nor expected benefits result; how patients and nicate and to lead 01hers. "Yo11r organization kind of appointment.,. families manage the recovery period; how age, values co111m1micatio11 skill a11d leadership," Broder In 1977 he returned to NIDR and was gender, activity patterns and expectations may said. ·'I hope 1hat, in accepting this award. some of named chief of che experimental morphology relate co recovery patterns; and the efficacy of those vfrt11es will be be.r1owed 011 me.,. seccion and acting chief of LBS; he became cclephone concacc with a nurse specialise dur­ chiefofLBS in 1978. From 1982 co 1983 he ing pacienc and family recovery at home. 0 page 12 The Record January 9, 1990

OPM's Loss, NIH's Gain Diane Armstrong Named Director, Division of Equal Opportunity

By Anne Barber Diane E. Armstrong, m::wly appointed Service Award in 1988 and 1989. direcrnr of NlH's Division of Equal Oppor­ A member of many organizations, including tunity, has worked for the federal government che Busint>ss and Professional Women's C!L1b, for 30 years. Most recently she served as chief she also serves as a volLmteer at Martha's of the Equal Employment Opportunity D ivi­ Table, a nonprofit organization chat prepares sion for the Office of Personnel Management. and delivers food to D.C. street people and Dr. William F. Raub, NIH acting director, prepares meals for children from needy said in announcing rhe appointme nt, "In addi­ families. 0 tion co her outstanding record in EEO management at OPM, Ms. Armstrong has established and nurtured several very successful Visitor Center Offers Tours career support programs for OPM employees." "I was thei r first full-time federal Women's The NIH Visitor Information Cencer (VIC) Program manager," Armstrong says. " I also in Bldg. LO is now offering a guided tour of established the first OPM FWP advisory com­ the N IH campus at 11 a.m. every Monday, miuce." Wednesday, and Friday. The tour begins at Serving as chairperson for chat committee, the VIC reception desk in rhe lower lobby of she planned and sponsored many workshops the Clinical Center. and seminars for OPM employees. For her For further information, call 496-1776. 0 accomplishments in chis area, Armstrong Diane AmtJtrong received an outstanding achievement award from rhe Federal Women's Inreragency Board. Ubell To Speak, Jan. 18 As FWP manager, she planned OPM's How does a journalist go abouc explaining annual observation of Black H istory Month. She also developed briefings for managers complicated medical research to the lay per­ "In fact," she says, "I planned the first obser­ and supervisors on EEO programs. She held son' Earl Ubetl, health editor for Parade vance the agency held in I 98 I." her first briefing for headquarters staff in 1988 magazine and health and science editor for ln 1986, Armstrong became chief of and completed the first regional briefing in WCBS-TV, New York, will talk about EEOD. A5 chief, she initiated development of Chicago just days before joining NIH. "Explaining the Unexplainable" ac an N IH the Communications Skills Improvement Pro­ In a letter to Armstrong on h