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Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H. -
EMBC Annual Report 2007
EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation -
2019 Annual Report
BECKMAN CENTER 279 Campus Drive West Stanford, CA 94305 650.723.8423 Stanford University | Beckman Center 2019 Annual Report Annual 2019 | Beckman Center University Stanford beckman.stanford.edu 2019 ANNUAL REPORT ARNOLD AND MABEL BECKMAN CENTER FOR MOLECULAR AND GENETIC MEDICINE 30 Years of Innovation, Discovery, and Leadership in the Life Sciences CREDITS: Cover Design: Neil Murphy, Ghostdog Design Graphic Design: Jack Lem, AlphaGraphics Mountain View Photography: Justin Lewis Beckman Center Director Photo: Christine Baker, Lotus Pod Designs MESSAGE FROM THE DIRECTOR Dear Friends and Trustees, It has been 30 years since the Beckman Center for Molecular and Genetic Medicine at Stanford University School of Medicine opened its doors in 1989. The number of translational scientific discoveries and technological innovations derived from the center’s research labs over the course of the past three decades has been remarkable. Equally remarkable have been the number of scientific awards and honors, including Nobel prizes, received by Beckman faculty and the number of young scientists mentored by Beckman faculty who have gone on to prominent positions in academia, bio-technology and related fields. This year we include several featured articles on these accomplishments. In the field of translational medicine, these discoveries range from the causes of skin, bladder and other cancers, to the identification of human stem cells, from the design of new antifungals and antibiotics to the molecular underpinnings of autism, and from opioids for pain -
Masondentinger Umn 0130E 1
The Nature of Defense: Coevolutionary Studies, Ecological Interaction, and the Evolution of 'Natural Insecticides,' 1959-1983 A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Rachel Natalie Mason Dentinger IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Mark Borrello December 2009 © Rachel Natalie Mason Dentinger 2009 Acknowledgements My first thanks must go to my advisor, Mark Borrello. Mark was hired during my first year of graduate school, and it has been my pleasure and privilege to be his first graduate student. He long granted me a measure of credit and respect that has helped me to develop confidence in myself as a scholar, while, at the same time, providing incisive criticism and invaluable suggestions that improved the quality of my work and helped me to greatly expand its scope. My committee members, Sally Gregory Kohlstedt, Susan Jones, Ken Waters, and George Weiblen all provided valuable insights into my dissertation, which will help me to further develop my own work in the future. Susan has given me useful advice on teaching and grant applications at pivotal points in my graduate career. Sally served as my advisor when I first entered graduate school and has continued as my mentor, reading nearly as much of my work as my own advisor. She never fails to be responsive, thoughtful, and generous with her attention and assistance. My fellow graduate students at Minnesota, both past and present, have been a huge source of encouragement, academic support, and fun. Even after I moved away from Minneapolis, I continued to feel a part of this lively and cohesive group of colleagues. -
April 2007 ASCB Newsletter
ASCB A P R I L 2 0 0 7 NEWSLETTER VOLUME 30, NUMBER 4 MBC: Eliminate Hogan, Meyerowitz Shapiro to the Printed Journal? Run for ASCB President Present Page 4 Brigid Hogan of Duke Medical Center and Elliot Meyerowitz of the California Institute Porter of Technology/HHMI are running for ASCB 47th ASCB President. The elected candidate will serve on the Society’s Executive Committee Lecture Annual Meeting as President-Elect in 2008 and as ASCB Lucy Shapiro President in 2009. of Stanford Program Brigid Hogan Duke Medical Eight candidates will compete for four three- University Page 8 Center year terms as Councilor. All those elected start School of service on January 1, 2008. Medicine has An email with a link to the Society’s been named NIH Director electronic ballot and candidate biographies Lucy Shapiro by ASCB Criticizes Bush will be sent to regular, postdoctoral, and President emeritus members. Bruce M. Stem Cell Policy The election closes on June 30. Results will Alberts to give the 26th Annual be announced in the July issue of the ASCB Keith R. Porter Lecture. Page 13 Elliot Meyerowitz Newsletter. Her lecture, “Spatial and California 2004 ASCB President Harvey F. Lodish Topological Components of Institute of of the Whitehead Institute for Biomedical Bacterial Cell Cycle Regulatory Inside Technology/ Circuitry,” will be presented HHMI Research served as Nominating Committee Chair; also serving on the Committee were during the 47th ASCB Annual Gary G. Borisy, Joanne Chory, Anthony P. Meeting in Washington, DC, President’s Column 2 Mahowald, Suzanne R. Pfeffer, Laura J. Robles, Pamela A. -
Pnas11052ackreviewers 5098..5136
Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H. -
Research Organizations and Major Discoveries in Twentieth-Century Science: a Case Study of Excellence in Biomedical Research
A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Hollingsworth, Joseph Rogers Working Paper Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research WZB Discussion Paper, No. P 02-003 Provided in Cooperation with: WZB Berlin Social Science Center Suggested Citation: Hollingsworth, Joseph Rogers (2002) : Research organizations and major discoveries in twentieth-century science: A case study of excellence in biomedical research, WZB Discussion Paper, No. P 02-003, Wissenschaftszentrum Berlin für Sozialforschung (WZB), Berlin This Version is available at: http://hdl.handle.net/10419/50229 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu P 02 – 003 RESEARCH ORGANIZATIONS AND MAJOR DISCOVERIES IN TWENTIETH-CENTURY SCIENCE: A CASE STUDY OF EXCELLENCE IN BIOMEDICAL RESEARCH J. -
Stem Cell Biology
HIGHLIGHTS AND FUTURE PROSPECTS VASSIE C. WARE, Ph.D. LEHIGH UNIVERSITY MULTIDISCIPLINARY APPROACHES BIOLOGICAL ENGINEERS BIOCHEMISTS MOLECULAR BIOLOGISTS NEUROBIOLOGISTS MICROBIOLOGISTS CHEMISTS CLINICIANS CELL BIOLOGISTS VIROLOGISTS BIOETHICISTS & PHYSICISTS MEDICAL HUMANISTS MECHANICAL ENGINEERS COMPUTER SCIENTISTS PROBLEMS IN BIOSCIENCE Genomics and Genomic Technologies Drug Delivery Ethical and social implications Obesity Cardiovascular Disease Neurological Disease Behavioral disorders Infectious Diseases Stem Cells and Regenerative Medicine Cancer Recent advances: Genomics and Genomic Technologies - understanding microbial genomes for biomedical applications and biofuel/bioremediation applications - drug development prospects - pharmacogenomics Stem Cell Biology - tracking stem cells in the brain to understand neurological disease - understanding disease mechanisms in the laboratory - drug development prospects Ethical Considerations First Bacterial Genome Transplantation Changes One Species To Another (Science, August 2007) Changed one bacterial species, Mycoplasma capricolum into another, Mycoplasma mycoides Large Colony (LC), by replacing one organism’s genome with the other one’s genome. WHY? …“We are committed to this research as we believe that synthetic genomics holds great promise in helping to solve issues like climate change and in developing new sources of energy.” ETHICAL AND SOCIAL CONCERNS? In collaboration with the Center for Strategic & International Studies (CSIS), and the Massachusetts Institute of Technology (MIT), -
Dr. Lucy Shapiro Is a Professor of Developmental Biology at Stanford School of Medicine Where She Holds the Virginia and RESEARCH with IMPACT D.K
UNIVERSITY LECTURE SERIES ONE SHEET Save the Date: How does a cell execute the many functions that define a living entity? We discovered that robust chemically and genetically based May 5 at 5:30 p.m. ET, Virtual Program logic circuits control cell cycle progression and cell differentiation. A critical question is how these control systems function in time and space within a tiny bacterial cell with just 4,000 genes. Lecture Title: We have observed strong parallels between these “genetic circuits” and familiar engineering circuits. These expanding insights The Living Cell as an Integrated System are providing unprecedented understanding of the asymmetric cell differentiation process essential to producing the diverse organisms found on the Earth. LUCY SHAPIRO Virginia and D.K. Ludwig Professor of Developmental Biology, Stanford University Developmental Biologist Researcher Educator Recipient of the 2020 Dickson Prize in Science “It’s the most exciting thing in the world to be a scientist, because FROM ARTIST TO SCIENTIST you’re like a detective — and what I do is try to understand what Shapiro’s start in scientific research took an unconventional life is by starting with a very, very simple bacterial cell and path. She describes her career journey from artist to scientist understanding the genetic circuitry that control a living thing.” in this profile fromThe Scientist. Her success in the field of — Lucy Shapiro developmental biology is a reminder that an interdisciplinary approach to problem-solving is fundamental to innovation. Dr. Lucy Shapiro is a professor of developmental biology at Stanford School of Medicine where she holds the Virginia and RESEARCH WITH IMPACT D.K. -
Contents Trade Offerings
CONTENTS TRADE OFFERINGS The Secret Life of the Brain 2 Richard Restak, M.D. Eclipse 4 Duncan Steel In Search of the Lost Cord 6 Luba Vikhanski The Genomic Revolution 8 Rob DeSalle and Michael Yudell How Students Learn 10 National Research Council A Case of Chronic Neglect 11 Felicia Cohn, Marla Salmon, and John Stobo Previously Announced Books and New and Recently Published Books Adding It Up 13 Jeremy Kilpatrick, Jane Swafford, and Bradford Findell Educating Children with Autism 14 Catherine Lord and James P.McGee Knowing What Students Know 15 James Pellegrino, Robert Glaser, and Naomi Chudowsky Speaking of Health 16 Institute of Medicine Backlist Offerings 30 General Information 34 October General Interest Science ISBN 0-309-07435-5 $35.00 8 x 10, 224 pages, index Cloth with jacket Color photographs and illustrations A Joseph Henry Press book Rights: World MARKETING • Concurrent publicity with airing of PBS series in early 2002 • Full-color blads • National review attention • National print advertising campaign • National media attention: radio and television • Co-op available 2 THE SECRET LIFE OF THE BRAIN Richard Restak, M.D. with a foreword by David Grubin Companion to the five-part television series brought to PBS by award- winning producer David Grubin, The Secret Life of the Brain takes readers on a tour of the human brain. Lavishly illustrated and beautifully presented, the many mysteries of the brain are explored from infancy to old age. en years ago a presidential proclamation ushered in the “Decade of the Brain.”We have Dr. Richard Restak since realized enormous benefits from this decade of discovery. -
21St Annual Meeting of the ISCE 23-27 July, 2005
21st Annual Meeting of the ISCE 23-27 July, 2005 1 21st Annual Meeting of the ISCE 23-27 July, 2005 Table of Contents Organizers, Officers & Sponsors ........................................................................................ 3 Conference at a Glance ....................................................................................................... 4 Hotel Map ........................................................................................................................... 5 Program............................................................................................................................... 6 Saturday, 23rd afternoon.................................................................................................. 6 Sunday, 24th morning...................................................................................................... 6 Sunday, 24th afternoon .................................................................................................... 7 Sunday, 24th evening....................................................................................................... 8 Monday, 25th morning..................................................................................................... 8 Monday, 25th afternoon................................................................................................... 9 Tuesday, 26th morning .................................................................................................. 11 Tuesday, 26th morning-afternoon................................................................................. -
SWEET-DISSERTATION-2018.Pdf
UNTANGLING THE COEVOLUTIONARY HISTORY BETWEEN DOVES AND THEIR PARASITIC LICE BY ANDREW DONALD SWEET DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Ecology, Evolution, and Conservation Biology in the Graduate College of the University of Illinois at Urbana-Champaign, 2018 Urbana, Illinois Doctoral Committee: Dr. Kevin Johnson, Chair, Director of Research Professor May Berenbaum Professor James Whitfield Associate Professor Brian Allan Assistant Professor Julian Catchen ABSTRACT In host-parasite systems, any given host species can be associated with multiple types of parasites, each of which can have a unique ecological relationship with the host. However, it remains unclear how these ecological differences link to evolutionary patterns. What shapes the dynamics of a host-parasite interaction over evolutionary time? An ideal approach for addressing this question is to compare multiple lineages of similar parasites that are associated with the same group of hosts but have distinct ecological differences – or “ecological replicates.” For my dissertation, I applied this strategy by focusing on the wing and body lice of doves. These two “ecomorphs” of lice are not closely related yet exclusively parasitize the same group of hosts. Notably, wing lice have a greater capability for dispersal than body lice. Dispersal is an important ecological component of host-parasite interactions and speciation in general. The first part of my dissertation examined broad cophylogenetic patterns across the dove-louse system. I found that wing and body lice did not have correlated patterns, and body lice showed more cospeciation with their hosts. This pattern agreed with previous studies, the results of which suggested that the increased cospeciation in body lice was due to differences in dispersal ability.