70 March 2021 Volume 70 Issue 3
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oue7 Ise3 Pages 445–630 Issue 3 Volume 70 Contents Volume 70 Issue 3 | GUT March 2021
GUT Commentary Inflammatory bowel disease 445 Regurgitation matters 485 SETDB1 is required for intestinal epithelial P J Kahrilas differentiation and the prevention of intestinal
March 2021 inflammation L Južnić, K Peuker, A Strigli, M Brosch, A Herrmann, Endoscopy news R Häsler, M Koch, L Matthiesen, Y Zeissig, Gut: first published as on 1 March 2021. Downloaded from Magnificent buildings in Greifswald’s 447 Impact of disconnected pancreatic duct on B-S Löscher, A Nuber, G Schotta, V Neumeister, Market Place, Germany. Read in this issue T Chavakis, T Kurth, M Lesche, A Dahl, the important study by Frost et al looking recurrence of fluid collections and new-onset A von Mässenhausen, A Linkermann, S Schreiber, at long-term instability of the intestinal diabetes: do we finally have an answer? microbiome and its association with K Aden, P C Rosenstiel, A Franke, J Hampe, metabolic liver disease and diabetes. J Basha, S Lakhtakia, Z Nabi, P Pal, R Chavan, S Zeissig R Talukdar, M Ramchandani, R Gupta, R Kalapala, An international journal of G Venkat Rao, D N Reddy gastroenterology and hepatology 499 Ranking microbiome variance in inflammatory Impact Factor: 19.819 bowel disease: a large longitudinal Editor intercontinental study Emad El-Omar (Australia) Oesophagus A G Clooney, J Eckenberger, E Laserna-Mendieta, Deputy Editor (Hepatology) 450 Number of reflux episodes on pH-impedance Alexander Gerbes (Germany) K A Sexton, M T Bernstein, K Vagianos, M Sargent, Deputy Editor (Luminal monitoring associates with improved symptom F J Ryan, C Moran, D Sheehan, R D Sleator, Gastroenterology) outcome and treatment satisfaction in gastro- L E Targownik, C N Bernstein, F Shanahan, William Grady (USA) oesophageal reflux disease (GERD) patients M J Claesson Deputy Editor (Endoscopy) Thomas Rosch (Germany) with regurgitation Associate Editors B D Rogers, L R Valdovinos, M D Crowell, R Bell, Guy Boeckxstaens (Belguim) M F Vela, C P Gyawali Gut microbiota Patrice Cani (Belgium) Jean-Francois Dufour (Switzerland) 511 Very early-life exposure to microbiota-induced Thomas Gress (Germany) 456 Global prevalence of Barrett’s oesophagus and TNF drives the maturation of neonatal pre-cDC1 Christian Jobin (USA) A Köhler, S Delbauve, J Smout, D Torres, V Flamand Ernst Kuipers (The Netherlands) oesophageal cancer in individuals with gastro-
Markus Neurath (Germany) oesophageal reflux: a systematic review and http://gut.bmj.com/ Siew C Ng (Hong Kong) meta-analysis 522 Long-term instability of the intestinal Francisco Real (Spain) Robert Thimme (Germany) L H Eusebi, G G Cirota, R M Zagari, A C Ford microbiome is associated with metabolic liver Herbert Tilg (Austria) disease, low microbiota diversity, diabetes Fabien Zoulim (France) Artificial Intelligence/ mellitus and impaired exocrine pancreatic Machine Learning Editor Stomach function Akbar Waljee (USA) Dissecting transcriptional heterogeneity in F Frost, T Kacprowski, M Rühlemann, M Pietzner, 464 on September 24, 2021 by guest. Protected copyright. Statistics Editors C Bang, A Franke, M Nauck, U Völker, H Völzke, Ruben Hernaez (USA) primary gastric adenocarcinoma by single cell Susan Hutfless (USA) RNA sequencing M Dörr, J Baumbach, M Sendler, C Schulz, Editorial Office M Zhang, S Hu, M Min, Y Ni, Z Lu, X Sun, J Wu, J Mayerle, F U Weiss, G Homuth, M M Lerch Gut B Liu, X Ying, Y Liu BMJ Journals BMA House, Tavistock Square London, WC1H 9JR, UK E: [email protected] ISSN: 0017-5749 (print) Endoscopy ISSN: 1468-3288 (online) 476 Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: Disclaimer: The Editor of Gut has been granted editorial freedom and Gut is published in accordance BEST-J score with editorial guidelines issued by the World Association of Medical Editors and the Committee W Hatta, Y Tsuji, T Yoshio, N Kakushima, on Publication Ethics. Gut is primarily intended for healthcare professionals and its content is for S Hoteya, H Doyama, Y Nagami, T Hikichi, information only. The Journal is published without M Kobayashi, Y Morita, T Sumiyoshi, M Iguchi, any guarantee as to its accuracy or completeness and any representations or warranties are expressly H Tomida, T Inoue, T Koike, T Mikami, K Hasatani, MORE CONTENTS ► excluded to the fullest extent permitted by law. J Nishikawa, T Matsumura, H Nebiki, Readers are advised to independently verify any information on which they choose to rely. D Nakamatsu, K Ohnita, H Suzuki, H Ueyama, Acceptance of advertising by Gut does not imply Y Hayashi, M Sugimoto, S Yamaguchi, T Michida, This article has been chosen by the Editor to be of special interest endorsement. Neither BSG nor BMJ Publishing Group Limited shall have any liability for any loss, T Yada, Y Asahina, T Narasaka, S Kuribasyashi, or importance and is freely available online. injury or damage howsoever arising from Gut (except for liability which cannot be legally excluded). S Kiyotoki, K Mabe, T Nakamura, N Nakaya, This article has been made freely available online under the BMJ Copyright © 2021 BMJ Publishing Group Ltd M Fujishiro, A Masamune Journals open access scheme. and British Society of Gastroenterology. All rights reserved; no part of this publication may be See http://authors.bmj.com/open-access/ reproduced in any form without permission. Gut is published by BMJ Publishing Group Ltd, typeset by Exeter Premedia Services Private Ltd, Chennai, India and printed in the UK on acid-free paper Member since 2008 Gut is published by BMJ Publishing Group Ltd, typeset JM00004 by Exeter Premedia Services Private Ltd, Chennai, This journal is a member of and subscribes to the principles of the India and printed in the UK on acid-free paper Gut (ISSN: 0017-5749) (USPS 2278) is published Committee on Publication Ethics bimonthly by BMJ Publishing Group Ltd, BMA www.publicationethics.org House,Tavistock Square, WC1H 9JR London. Airfreight and mailing in the USA by agent named World Container Inc, 150-15, 183rd Street, Jamaica, NY 11413, USA. Periodicals postage paid at Brooklyn, NY 11256. US Postmaster: Send address changes to Gut, World Container Inc, 150-15, 183rd Street, Jamaica, NY 11413, USA. Subscription records are maintained at BMA House, Tavistock Square WC1H 9HR Lodnon. Air Business Ltd is acting as our mailing agent. Contents Volume 70 Issue 3 | GUT March 2021
COVID-19 575 Naturally occurring 5′ preS1 deletions markedly 531 Comparison of mortality risk in patients with enhance replication and infectivity of HBV cirrhosis and COVID-19 compared with patients genotype B and genotype C with cirrhosis alone and COVID-19 alone: J Li, J Li, S Chen, Q Yuan, J Zhang, J Wu, Q Jiang, multicentre matched cohort Q Wang, N-S Xia, J Zhang, S Tong J S Bajaj, G Garcia-Tsao, S W Biggins, P S Kamath, F Wong, S McGeorge, J Shaw, M Pearson, M Chew, 585 Alpha-1 antitrypsin governs alcohol-related liver Gut: first published as on 1 March 2021. Downloaded from A Fagan, R de la Rosa Rodriguez, J Worthington, disease in mice and humans A Olofson, V Weir, C Trisolini, S Dwyer, C Grander, B Schaefer, J Schwärzler, F Grabherr, K R Reddy D M de Graaf, B Enrich, G Oberhuber, L Mayr, M Sangineto, N Jaschke, T E Adolph, M Effenberger, 537 Impact of the COVID-19 pandemic on UK A R Moschen, C A Dinarello, H Zoller, H Tilg endoscopic activity and cancer detection: a National Endoscopy Database Analysis M D Rutter, M Brookes, T J Lee, P Rogers, L Sharp Recent advances in basic science 595 Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health Artificial intelligence/machine learning M Fassarella, E E Blaak, J Penders, A Nauta, 544 Image-based consensus molecular subtype H Smidt, E G Zoetendal (imCMS) classification of colorectal cancer using deep learning K Sirinukunwattana, E Domingo, S D Richman, Recent advances in clinical practice K L Redmond, A Blake, C Verrill, S J Leedham, 606 DNA damage repair as a target in pancreatic A Chatzipli, C Hardy, C M Whalley, C Wu, cancer: state-of-the-art and future perspectives A D Beggs, U McDermott, P D Dunne, A Meade, L Perkhofer, J Gout, E Roger, F Kude de Almeida, S M Walker, G I Murray, L Samuel, M Seymour, C Baptista Simões, L Wiesmüller, T Seufferlein,
I Tomlinson, P Quirke, T Maughan, J Rittscher, http://gut.bmj.com/ A Kleger V H Koelzer, On behalf of S:CORT consortium
JournalScan Colon 618 GI highlights from the literature 555 Naproxen chemoprevention promotes immune P J Smith
activation in Lynch syndrome colorectal on September 24, 2021 by guest. Protected copyright. mucosa L Reyes-Uribe, W Wu, O Gelincik, P V Bommi, PostScript A Francisco-Cruz, L M Solis, P M Lynch, R Lim, 620 Letters E M Stoffel, P Kanth, N J Samadder, M E Mork, M W Taggart, G L Milne, L J Marnett, L Vornik, D D Liu, M Revuelta, K Chang, Y N You, L Kopelovich, I I Wistuba, J J Lee, S Sei, R H Shoemaker, E Szabo, E Richmond, A Umar, Editor’s quiz: GI snapshot M Perloff, P H Brown, S M Lipkin, E Vilar 475 ‘Blast from the past’ colonoscopy complication treated with a novel approach M Shiha, S Laidlaw, L Hunt, A D Hopper Hepatology 567 Three-dimensional bioprinted hepatorganoids Electronic page prolong survival of mice with liver failure e1 Correction: Gastroenterology department H Yang, L Sun, Y Pang, D Hu, H Xu, S Mao, W Peng, Y Wang, Y Xu, Y-C Zheng, S Du, operational reorganisation at the time of H Zhao, T Chi, X Lu, X Sang, S Zhong, X Wang, COVID-19 outbreak: an Italian and Chinese H Zhang, P Huang, W Sun, Y Mao experience