Contents Volume 61 Issue 10 | GUT October 2012

Commentaries Colon 1375 Evidence or eminence: optimising patient 1435 Entopic overexpression of Ascl2 does not outcomes by choosing the right doctor? accelerate tumourigenesis in ApcMin mice P L Lakatos, G Veres K R Reed, S J Tunster, M Young, A Carrico, R M John, A R Clarke Gut: first published as on 1 October 2012. Downloaded from 1377 Improving drug delivery to pancreatic cancer: Caption: Illustration of a typical gastric parietal cell, which secretes hydrochloric acid, intrinsic factor breaching the stromal fortress by targeting 1439 Outcomes of the Bowel Cancer Screening and cytokines such as interleukin-11 (see article by hyaluronic acid Programme (BCSP) in England after the fi rst Howlett et al in this issue of Gut). P Michl, T M Gress 1 million tests R F A Logan, J Patnick, C Nickerson, L Coleman, An international journal of Original articles M D Rutter, C von Wagner, on behalf of the English gastroenterology and hepatology Bowel Cancer Screening Evaluation Committee Impact Factor: 10.111 Oesophagus Editor 1380 Barrett’s metaplasia glands are clonal, contain Emad El-Omar (UK) multiple stem cells and share a common Deputy Editor (Hepatology) squamous progenitor 1447 miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in Alexander Gerbes (Germany) A M Nicholson, T A Graham, A Simpson, colorectal cancer Deputy Editor (Luminal A Humphries, N Burch, M Rodriguez-Justo, Gastroenterology) M Novelli, R Harrison, N A Wright, Y Ma, P Zhang, F Wang, H Zhang, J Yang, J Peng, William Grady (USA) S A C McDonald, J A Jankowski W Liu, H Qin Associate Editors Matias Avila (Spain) Guy Boeckxstaens (Belguim) 1390 Changes in prevalence, incidence and Pancreas Laurence Egan (Ireland) spontaneous loss of gastro-oesophageal refl ux 1454 Concurrent PEDF defi ciency and Kras mutation Thomas Gress (Germany) symptoms: a prospective population-based induce invasive pancreatic cancer and Ernst Kuipers (The Netherlands) cohort study, the HUNT study adipose-rich stroma in mice Julian Panes (Spain) P J Grippo, P S Fitchev, D J Bentrem, L G Melstrom, Herbert Tilg (Austria) E Ness-Jensen, A Lindam, J Lagergren, K Hveem S Dangi-Garimella, S B Krantz, M J Heiferman, Fabien Zoulim (France) http://gut.bmj.com/ C Chung, K Adrian, M L Cornwell, J B Flesche, Editorial Offi ce Gut Stomach S M Rao, M S Talamonti, H G Munshi, S E Crawford BMJ Journals 1398 IL-11 is a parietal cell cytokine that induces BMA House, Tavistock Square London, WC1H 9JR, UK atrophic gastritis M Howlett, H V Chalinor, J N Buzzelli, N Nguyen, Hepatology T: +44 (0)20 7383 6394 Discoidin domain receptor 2 defi ciency F: +44 (0)20 7383 6668 I R van Driel, K M Bell, J G Fox, E Dimitriadis, 1465

predisposes hepatic tissue to colon carcinoma on September 28, 2021 by guest. Protected copyright. E: [email protected] T R Menheniott, A S Giraud, L M Judd ISSN: 0017-5749 (print) metastasis ISSN: 1468-3288 (online) Infl ammatory bowel disease I Badiola, E Olaso, O Crende, S L Friedman, F Vidal-Vanaclocha Disclaimer: Gut is owned and published by BMJ 1410 Impact of gastroenterologist care on health Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association and the British outcomes of hospitalised ulcerative colitis Society of Gastroenterology. The owners grant editorial freedom to the Editor of Gut. Gut follows patients guidelines on editorial independence produced by S K Murthy, A H Steinhart, J Tinmouth, P C Austin, the World Association of Medical Editors and the code on good publication practice of the G C Nguyen Committee on Publication Ethics. Gut is intended for medical professionals and is provided without warranty, express or implied. 1417 The human milk oligosaccharide disialyllacto- Statements in the Journal are the responsibility of their authors and advertisers and not authors’ N-tetraose prevents necrotising enterocolitis in MORE CONTENTS ᭤ institutions, the BMJ Publishing Group, the British Society of Gastroenterology or the BMA unless neonatal rats otherwise specifi ed or determined by law. E Jantscher-Krenn, M Zherebtsov, C Nissan, K Goth, Acceptance of advertising does not imply This article has been chosen by the Editor to be of special interest endorsement. Y S Guner, N Naidu, B Choudhury, A V Grishin, or importance and is freely available online. To the fullest extent permitted by law, the BMJ H R Ford, L Bode Publishing Group shall not be liable for any loss, Articles carrying the Unlocked Logo are freely available online injury or damage resulting from the use of Gut or any information in it whether based on contract, under the BMJ Journals unlocked scheme. tort or otherwise. Readers are advised to verify any Endoscopy See http://gut.bmj.com/info/unlocked.dtl information they choose to rely on. 1426 Adenoma detection with cap-assisted Copyright © 2012 BMJ Publishing Group Ltd and British Society of Gastroenterology. All rights colonoscopy versus regular colonoscopy: reserved; no part of this publication may be a randomised controlled trial reproduced, stored in a retrieval system or This journal is a member of and subscribes to the principles of the transmitted in any form or by any means, T R de Wijkerslooth, E M Stoop, P M Bossuyt, electronic, mechanical, photocopying, recording Committee on Publication Ethics or otherwise without prior permission E M H Mathus-Vliegen, J Dees, K M A J Tytgat, www.publicationethics.org.uk Gut is published by BMJ Publishing Group Ltd, M E van Leerdam, P Fockens, E J Kuipers, E Dekker typeset by Techset and printed in the UK on acid-free paper. Gut (ISSN: 0017-5749) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Gut, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA.

gutjnl_61_10_TOC.indd 1 05/09/12 5:38 PM Contents Volume 61 Issue 10 | GUT October 2012

1473 Insulin resistance and response to telaprevir plus Receive regular table of contents by email. Recent advances in clinical practice Register using this QR code. peginterferon α and ribavirin in treatment-naïve 1501 Failure of refl ux inhibitors in clinical trials: patients infected with HCV genotype 1 bad drugs or wrong patients? L Serfaty, X Forns, T Goeser, P Ferenci, F Nevens, P J Kahrilas, G Boeckxstaens G Carosi, J P Drenth, I Lonjon-Domanec, R DeMasi, G Picchio, M Beumont, P Marcellin JournalScan Gut: first published as on 1 October 2012. Downloaded from 1510 GI Highlights from the literature 1481 Prospective validation of an immunohistochemi- M H McLean cal panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma Editor’s quiz: GI snapshot S Tremosini, A Forner, L Boix, R Vilana, L Bianchi, 1512 Recurrent epigastric pain with obscure GI M Reig, J Rimola, C Rodríguez-Lope, C Ayuso, bleeding; think beyond the bowel? M Solé, J Bruix M C-W Hu, P V Kaye, I J Beckingham, M W James

Recent advances in basic science PostScript 1488 Genetically engineered mouse models of 1513 Letters pancreatic cancer: unravelling tumour biology and progressing translational oncology P K Mazur, J T Siveke http://gut.bmj.com/ on September 28, 2021 by guest. Protected copyright.

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