ASI news December 2018

Women’s Initiative 2018 wrap up P12

10 19 Contact Us Australasian society for ASI2018 Annual 2017 Jared Purton Immunology Inc. Scientific Meeting Award Recipient ASI Inc. Seretariat approximately 420 Dr Arabella Young, NHMRC PO Box 1371, delegates attended the CJ Martin Overseas Fellow Mitcham North 3132 ASI2018 annual scientific Ph: 03 8393 9388 meeting in Perth immunology.org.au/contact-us

2018 CTI CiteScore 3.55

Cutting-edge advances in biomedical research

Editor-in-Chief: Rajiv Khanna

Clinical & Translational Immunology is an open access, online-only journal, seeking to cover basic, translational and clinical studies in all aspects of human immunology, including experim

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Catch up on recent Special Features from Clinical & Translational Immunology, including:

CTI Special Feature on Endoplasmic Reticulum and Oxidative Stress in Immunopathology Special Feature Coordinator: Sumaira Z Hasnain Endoplasmic reticulum (ER) stress and related molecular programs, which occur ASI Newsletter DECEMBER 2018

contents

President’s report...... 4 WA Branch Report...... 25 Susanne Heinzel Connie Jackaman, WA branch Councillor

secretary’s report...... 7 NSW Branch Report...... 26 Elissa Deenick Helen McGuire, NSW branch Councillor

treasurer’s report...... 8 Visiting Speaker Program updates...... 28 Kim Jacobson Stuart Mannering, VSP Coordinator

2019 Incoming President’s Address...... 9 The IUIS corner...... 29 John Fraser J. Alejandro Lopez

ASI2018 Annual Scientific Meeting...... 10 travel REPORTS...... 30 Connie Jackaman and Scott Fisher Keystone Symposia on B cells, Germany...... 30 Imogen Moran Women’s Initiative 2018 wrap-up...... 12 Vanessa Bryant Toll 2018: Editing Innate Immunity, Portugal...32 Kaiwen Chen Gender equity and inclusion policy...... 14 for speakers and session chairs at ASI events 5th European Congress of Immunology, The Netherlands...... 33 Meet the ICB Editorial Team...... 16 Ann Ly Anne La Flamme Gordon Research Conference on Protein 2017 Jared Purton Award Recipient...... 19 Processing, Trafficking and Secretion, USA.....34 Dr Arabella Young Natalie Borg 2017 Gordon Ada Senior Award 17th Meeting of the Society for recipient - Katherine Kedzierska...... 21 Natural Immunity (NK2018), USA...... 36 Catherine Somerville Fernando Souza Fonseca Guimaraes

BRANCH REPORTS...... 24 Publications of Interest...... 37 SA/NT Branch Report...... 24 Our Sustaining Members Iain Comerford, SA & NT branch Councillor Australasian Society NZ Branch Report...... 25 for Immunology Inc...... 40 Ries Langley, NZ Councillor

9 16 30

2019 Incoming Meet the ICB KEYSTONE SYMPOSIA President’s Address Editorial Team ON B CELLS, GERMANY John Fraser Anne La Flamme Imogen Moran intoduces the new Editorial Board members

3 President’S REPORT ASI Newsletter DECEMBER 2018

President’s report Susanne Heinzel, out-going ASI president

This is my last newsletter column as ASI president. As I’m writing this, finalised. I’ve just returned from the ASI conference in Perth. And what a fabulous But we need to look further how meeting that was. we can support the membership. Last year we set aside $200k and The meeting was outstanding on Our financial position allows us asked membership for ideas, every level, the organisers have to investigate ways how we can however this hasn’t delivered done a brilliant job, the venue better support our members. many concrete plans or concepts. worked really well, the science We have already doubled the What has emerged though was outstanding and I liked the amount of travel bursaries and throughout the years is that mix of topics, and it was great international travel awards members sometimes approach to catch up with old friends and and hopefully this will allow us with ideas that we would colleagues, meet new people most of our student members like to support but don’t have and peers, learn new things and to obtain one of these during an appropriate funding scheme get new ideas. ASI meetings their postgraduate studies. For for. I’m therefore very pleased to are about so much more than the Perth meeting we gave out announce that we have created just hearing about the latest 45 bursaries in total, >60% for a ‘special ideas fund’ where advances in Immunology and students and >50% for postdocs. members can apply for financial Connie and Scott and their team We have also created the travel support for ideas and schemes have really delivered a perfect award for women to attend to that benefit our membership that environment for that. the annual meeting, which has are not covered elsewhere. The become a successful scheme. Overall, what a year this has details are currently finalised and For the first time we were been. I’m very pleased to will be announced in the next few supporting child care facilities at report that we have once again months. our annual meeting. While the exceeded the magic number I’m also very excited to announce uptake was relatively low, this of 1000 members! This is due that we will run the inaugural is only the start and I hope this to no small part to our General ASI advanced training course in will only grow over time, when Manager Tyani Chan and her parents become more aware of tireless efforts working through the option to bring their children. our database and the renewal We have already doubled the A more detailed report on this system that she inherited and an ‘ASI-Creche’ will be in this (or the amount of travel bursaries and active membership drive. Around next) ASI newsletter. We have international travel awards and a quarter of our members are restructured our Special Interest hopefully this will allow most new to the society and this is a Groups and have set aside funds wonderful reassurance that ASI of our student members to for SIG events. The details on and our programs are received obtain one of these during their how the SIGs can apply for well in the community. postgraduate studies. these funds are currently being

4 President’S REPORT ASI Newsletter december 2018

June 2019 (if all goes to plan). excellent position to lead the way I was able to visit some branches The course will be held at the by ensuring that we are not only at their branch retreats or other Illuka retreat, Red Hill, VIC (yes, applying these policies to our occasions. The enthusiasm of the that is amongst beautiful scenery own meetings, but to any event and very near to some lovely that is supported by ASI. branch committees to support wineries) will run over 3 nights their members (particularly Overall I think we are in a very and is aimed at ASI early career good shape and have some students and early career members (advanced PhD and exciting new schemes and members) is wonderful to see. Masters students and early career initiatives in place. Attending the and early career members) is post-docs). The theme for the Perth meeting really drove home wonderful to see. Thanks to first course is ‘Ageing and the to me once again what a great Connie Jackman, Ian Cockburn immune system’ and we will send society the ASI is, I’m so proud and Iain Comerford as outgoing out more details soon. Please of the culture and every single branch councillors. All of spread the word and look out for person in ASI, it is such an honour you have led your respective the announcements. to be part of it. branches brilliantly over the past Given our location and the Immunology in Aus and NZ is 3 years. current funding situation it is highly regarded throughout the I would also like to extend special critical to build relationship world, our visitors from overseas thanks to our non-voting council. with other societies. These love to come here and interact Firstly Vanessa Bryant, who really collaborations generally greatly with the members of the society. moved the Women’s Initiative increase the potential to apply Our annual meeting is viewed forward, Meredith O’Keeffe, for funding, build CVs and often highly in the world and those who did a fantastic job advising enhance research outputs. We speakers who come for the first the LOCs on the meetings and have been approached by other time keep telling us how special Laura MacKay, who did such a societies in the past (i.e. from (in a good way, they assure me) brilliant job on FIMSA council that Brazil and Singapore) and have the meeting and our culture is. she was recently elected FIMSA an existing ongoing program with They love the collegiality and president! Congratulations to the Germans via the DGfI-ASI good humour, the quality of Laura! First female and I think workshop. We are investigating a the science, the Burnet Oration also one of the youngest FIMSA session at the AAI meeting 2020 and Foundation Lectures and presidents in FIMSA history! through our journals. The BSI is the overall atmosphere. This also very interested to build a is only possible through the I want to take this opportunity joint program and I would highly fantastic people that make up too to give my very special encourage everybody to actively our membership. Such culture thanks to our outgoing treasurer seek new interactions with other doesn’t just happen, it needs to Kim Jacobson. Kim became societies. be nurtured and I would like to treasurer in 2016 before ICI, when we still didn’t know how We have developed strong thank all members of the society ICI would pan out. That was policies on gender equity for for contributing to this. So much very brave of her. Kim has done ASI supported events. The work goes on in the background, a great job looking after our importance of having strong from our branch councillors, finances, she has always had policies has become acutely the meeting organisers, the a very measured and careful obvious recently while I was speakers, the debaters, the approach based on the situation involved in the selection of councillors running the Women’s and I always felt very reassured speakers at two international initiative, representing us at the that our finances were in save meetings. The resistance to international unions of IUIS and hands with her. She was reluctant ‘give up’ slots for male speakers FIMSA, the newsletter editors to spend money when we didn’t is remarkable. Amongst many and so many more. know how much we’d have and other comments I was met with Our branches play such an has been committed to increase remarks suggesting that the important role to the local the support to our members once quality of the sessions / the membership. I was able to visit she knew that we could. Her goal event would be lowered if one some branches at their branch was always the long term viability adhered to the gender and / or retreats or other occasions. of ASI and our programs. This regional diversity policy. There The enthusiasm of the branch has helped to set up the path is still a lot of work ahead of us, committees to support their and structure for some long term but I believe that we are in an members (particularly students initiatives that our members will 5 President’S REPORT ASI Newsletter DECEMBER 2018

benefit from for many years to of responsibility and there were a society. Nonetheless I hope that come. She’s handing over our lot of expectations. Some might the overall goal of expanding an finances in a very sound state to argue we could have spent more inclusive society that looks after the very capable hands of Asolina money here and now, but I hope their members and provides as Braun. we made the right decisions to lay many opportunities to advance a solid foundation for the future knowledge, science and careers So thanks Kim, it’s been great and to carefully consider the best and general opportunities for working with you. schemes and programs to invest our members has not been lost Last but not least a few personal in our membership long term. completely. I took ASI over in words. When I took over as great shape from Chris and I I think all presidents come in president in 2017 we had just believe that I’m handing over to with big plans and ideas and I made a lot of money and had John in an equally good position. was no different. But some of never been in a better financial And I know it is in excellent those plans had to give way to position, thanks to ICI and our hands with John. Thanks to all the inevitable – getting bogged journals. This was a great position who helped me along the way. down in details and the simple to be in, but it came also with a lot day-to-day running of the

Australasian Society for Immunology Inc. PO Box 1371, Mitcham North 3132 VIC P: +61 3 8393 9388 E: [email protected]

6 secretary’S REPORT ASI Newsletter december 2018

secretary’s report Elissa Deenick, Honorary Secretary E: [email protected]

I’d like to add my thanks to Su’s to all the outgoing members of Margaret Baird - Women in Immunology Award – council. Thanks for all the hard work you’ve put into the society, Eligibility and Criteria it’s been great working with you for the last 3 years. Background: This meant we had a call several to look back and see all that This award was established in months ago for new council we’ve been able to do. One of 2018 in memory of Professor members. We had a great the things we’ve been able to Margaret Baird, a New Zealand response to the call meaning we do is to increase the awards that immunologist who passed away had elections for several positions are available to our members to in 2016. Margaret was known for - it was great to see so many help support their careers. At her work on dendritic cells, but of our members wanting to be mid-year council meeting we also as a mentor and supporter of actively involved in ASI. decided to double the funding for women in science. She prepared International Travel Awards and The results are in and I’d like to multiple reports and analyses on Travel bursaries for the annual welcome our incoming council the status of women in academia meeting. The impact of this was members: and in science and was a role already seen in Perth with over model for several generations 40 students or postdocs receiving Voting council of postgraduate students. bursaries to help them attend the • SA/NT branch councillor Margaret’s door was always open meeting. – Damon Tumes and her distinctive laugh lives • ACT branch councillor This increase in funding also – Anselm Enders means we’re increasing the number of Gordon Ada Senior • WA branch councillor awards we’ll be giving next year – Bree Foley and moving to two rounds of applications per year for these Non voting council awards. Look out in the next • Meeting co-ordinator Newsletter for a summary of all – Antje Blumenthal the awards that are available so • Women’s initiative co-ordinator you can make sure that you meet – Kylie Quinn the deadlines and can benefit fully from the opportunities available. • IUIS rep – Alejandro Lopez (reappointed) One thing I will mention now is the introduction of the Margaret • FIMSA rep – Jo Groom Baird – Women in Immunology Professor Margaret Baird At the end of the year it’s great Award. (photograph: Susanne Heinzel)

7 secretary’S REPORT cont. & treasurer’S REPORT ASI Newsletter december 2018

long in the halls of the University all applicants will need to current VSP programme. The of Otago. Margaret was an active demonstrate a leadership role in lectures should be given within member of ASI and was awarded supporting and mentoring women the calendar year following the Derek Rowley Medal in 2013 in immunology. the receiving of the award. It for her service to the society. is expected that the funds and Margaret was known for her recognition by the Society Purpose: work on dendritic cells, but also will make a major difference The award will provide an early- to the career advancement of as a mentor and supporter of mid career immunologist (and ASI the awardee. Selection of the member) with an advancement women in science. awardee will be based on this opportunity in teaching through criterion, with preference for the funding of a trans-Tasman outstanding individuals not lectureship. This lectureship will Award Value: already recognised by awards of involve a series of guest lectures The value of the award is $5000 to this nature, taking into account across New Zealand and Australia, go towards trans-Tasman return the prior achievements relative focusing on the applicant’s airfares, accommodation, internal to opportunity (CV), and evidence research, but also including travel and transfers, dinners of their support and mentoring of perspectives on equity and with hosts, and includes a $500 women in immunology. balance in science careers. While personal award. not limited to female applicants, Eligibility: Criteria: Applicants must be current ASI While not limited to female The awardee is expected to give members who were also financial at least 2 lectures in each of New applicants, all applicants members for at least the year Zealand and Australia (and not prior to the year of application. will need to demonstrate a in the applicants home state or Awardees are required to leadership role in supporting region). The visits and hosts are maintain their membership during and mentoring women in to be coordinated with branch the year the lectureship funded immunology. councillors or their nominees, by the award is being undertaken. in much the same way as the

treasurer’s report Kim Jacobson, out-going ASI Treasurer

The full financial report of ASI for the year ended 31st July 2018 can be accessed via the ASI member’s portal on the society website. (www.immunology.org.au/financial-reports/) Please note you must be logged in.

8 2019 Incoming President’s Address ASI Newsletter december 2018

2019 Incoming President’s Address John Fraser E: [email protected]

It is both an honour and privilege to begin my term as the new president and collaborate with those at the heart of our science and to of the Australia and New Zealand Society for Immunology. My first task is foster collaboration amongst our to warmly acknowledge Su Heinzel as the outgoing president. members. We are two countries at the bottom of the Pacific but Su’s presidency has been more important than ever that ASI’s purpose has always been to marked by a number of positive we think about how our research minimise that isolation through initiatives such as the Advanced can and will make a difference. our superb annual conference Training Course scheduled for Over the 30 years I’ve been a and support for fellowships, June 2019. Congrats Su on an member of ASI, there have been travel and particularly supporting outstanding presidency! In the many dramatic phases from the young investigators looking background the Society has a the early days of TcR and MHC to establish a research career – new management company structure, to Th1/2 subsets, Treg, not the easiest thing to do! Association Executive Services DCs, TLR and the inflammasome (AES) and General Manager Tyani You will note that we are no and now tumour immunotherapy Chan to ensure our back office longer the Australasian Society – the progress has been breath- runs smoothly and professionally. for Immunology. The name taking and many of our members has been officially changed to ASI is in very good hands both have been involved in those Australian and New Zealand financially and scientifically. As discoveries. Most importantly Society for Immunology but we end 2018, there has never ASI has and continues to be the our internationally recognized been a better time to call oneself important vehicle to connect acronym ASI will remain. This an immunologist. The impact removes the confusing term that our science is making on Australasian - which was often clinical medicine is profound but ASI has and continues to be the shortened to Australian. we must be mindful that medical important vehicle to connect advances always begin with basic and collaborate with those at I look forward to serving you discovery. Funding agencies the heart of our science and to all over the next two years and often demand direct sight of foster collaboration amongst would welcome suggestions on clinical relevance before agreeing how we can further improve our our members. to fund research, so it is now society.

9 ASI2018 Annual Scientific Meeting ASI Newsletter december 2018

ASI2018 Annual Scientific Meeting Connie Jackaman and Scott Fisher, 2018 ASI Annual Meeting Organisers Perth, WA, December 2nd-6th 2018

This year we saw approximately 420 delegates attending the ASI2018 annual scientific meeting in Perth, including a large contingency of students with the doubling of ASI travel bursaries. Highlights of the conference *disclaimer: this may not be included Ken Shortman’s exactly as performed by Anne, Foundation lecture (including please contact Anne for further “what not to do”), Franca details. Ronchese’s inspirational Burnet The Lafferty debate was won Oration, Su Heinzel’s fantastic by the opposition team (captain President’s lecture, as well as a Helen McGuire, Kate Schroder and dynamic scientific program with Phil Hodgkin) who just edged out outstanding international and the affirmative team (captain Tom national speakers. Importantly, Ashhurst, Claudine Bonder and this was the first ASI annual Graham Le Gros). This may have Charis Teh (left) and Rhea Longley scientific meeting to host been due to the late inclusion (right), Women’s Initiative Award childcare facilities onsite and I am Recipients of a cameo appearance by Luke sure this initiative will continue to O’Neill with a guitar. Some called build at future ASI meetings. this cheating, but all’s fair in re-wrote this report 3 times. The social functions were love and war….. and the Lafferty Each version looked relatively the incredibly well received and debate. Side note: for writing this same so it turns out n of 3 really is highlighted key locations around meeting report I decided to take enough (thanks Kate/Phil/Helen). Perth; including the Welcome Tom/Claudine/Graham’s advice Reception at Elizabeth Quay and and put the previous meeting Finally, a big thank you to all the conference dinner at Beaumonde reports (2013-2017) through the sponsors as the event would not on the Point, Point Fraser. There Harry Potter Botnik so that I could have been possible without their were also many laughs with the head to the beach. Botnik wrote very generous support. Also big Lafferty debate topic “Size Does that we had over 4000 delegates thanks to the local organising Matter: Big Data is Best”. The best attend (pretty good), but committee: Michaela Lucas, Chris limerick was won by Anne La Hermione Granger had won all the Andoniou, Joost Lesterhuis, Delia Flamme along the themes of “Big prizes and her family was eaten Nelson, Iona Schuster, Jonatan Data”, which went something like (not good……). I then decided to Leffler, Caitlyn Tilsed, Lelinh this*:- go back the drawing board and Duong, Amy Prosser, Bree Foley, Niamh Troy, Demelza Ireland, 01 001 00101 Alistair Cook, Jeanne Edmands, 01 001 00101 The social functions were Mark Agostino, Emma De Jong, 01 01 incredibly well received and Dino Tan, Senta Walton and Mel 01 01 highlighted key locations McCoy. A special thanks as well to key ASI central liaisons Su 01 001 00101 around Perth.

10 ASI2018 Annual Scientific Meeting ASI Newsletter december 2018

Heinzel, Meredith O’Keeffe and Tullett, Imogen Moran, Sarah Tyani Chan for all their help and Gabriel, Jason White, Tom advice; they were essentially extra Sidwell, Jessica Engel, Pirooz members of our local organising Zareie, Catarina Filipa dos- committee! Finally, we are also Santos Sá e Almeida, Marios very appreciative of the volunteer Koutsakos, Simone Park, Jessica social media ambassadors, Tempany, Xavier Yi Xiong Sng, photographers and of course Julia Bier Nogueira all the delegates for attending • ASI Women’s Initiative and making ASI2018 a great Bursaries: Charis Teh, Rhea conference! Longley, Carine Farenc, Some posts and images captured Hongyan An from twitter (thanks everyone!) • ASI Poster Award: Catriona Lafferty Debate, the winners with a are included and you can also special guest appearance Nguyen-Robertson check out at #ASI2018WA • ICB Poster Award: So Ri Jung Congratulations to all of the meeting-related prize winners:- • CTI Poster Award: Madeline Massy-Westropp • Pharmaxis-ASI Travel Bursary: Elena Cavallaro • Overall ASI Poster Award: Sherly Mardiana • ASI Travel Bursaries: Simone Nüssing, Thomas Ashhurst, • ASI New Investigator Award Caitlin Abbott, Meg Donovan, (sponsored by Pfizer): Imogen Deborah Burnett, Tina Nguyen, Moran Ruth Marian Guzman-Genuino, • BD Science Communication Luca Hensen, Rochelle Tixeira, Award: joint award to Amy Timona Tyllis, Minyu Wang, Prosser and Catriona Nguyen- Karolina Bednarska, Sherly Robertson Mardiana, Bethany Pillay, Maria Auladell Bernat, Tamekha • Amazing race winner: Katherine Develyn, Md. Al Amin Sikder, Goodall. Her “Perth-ect Milda Naciute, Kerrie Foyle, Experiment” was to perform Juewan Kim, Anthony Lau, a high throughput RNAseq to determine if WT (Perth) or Etienne Masle-Farquhar, Burnet Orator, Frana Ronchese Isabella Kong, Pengcheng Zhou, Quokka KO (not Perth) people Amanda Oliver, Elise Gressier, express higher “happy” genes. Emma Grant, Kirsteen McInnes

Foundation Lecture, Ken Shortman President’s lecture, Susanne Heinzel

11 Women’s Initiative 2018 wrap-up ASI Newsletter december 2018

Women’s Initiative 2018 wrap-up Vanessa Bryant, Outgoing Women’s Initiative Coordinator

Gender equity and inclusion Congratulations to Connie ASI seeks to ensure that Jackaman, Scott Fisher, Michaela policy for speakers and session Lucas and the Perth scientific students, early career chairs at ASI events program team (Chris Andoniou, researchers and (senior) Gender equality is achieved Joost Lesterhuis, Delia Nelson academics from all backgrounds when people are able to access and Iona Schuster) for putting are encouraged to participate together a diverse and stimulating and enjoy the same rewards, in all aspects of the conference resources and opportunities program and for working so regardless of gender. To support hard to provide on-site childcare regardless of gender, gender ASI’s commitment to gender for the first time at an ASI expression, sexual orientation, equity, this year the Women’s conference! ethnicity, nationality, disability, Initiative developed policy to We are proud to report that at this religion or age. ensure that the ASI is proactive in year’s meeting female speakers ensuring gender equity at annual meetings and symposia and meetings financially supported by ASI. This visible display of gender equity will contribute to an equal number of females and males being acknowledged for their achievements, provides opportunities for emerging research leaders and increases the diversity of role models for meeting attendees. Further, to support inclusiveness and diversity, ASI seeks to ensure that students, early career researchers and (senior) academics from all backgrounds are encouraged to participate in all aspects of the conference regardless of gender, gender expression, sexual orientation, ethnicity, nationality, disability, religion or age. For more information, see the Gender (Left to right) Dr Rhea Longley (WEHI); Dr Charis Teh (WEHI); Dr Carine Farenc Equity and Inclusion Policy (Monash); Dr Hongyan An (Kirby Institute) featured in this newsletter issue.

12 Women’s Initiative 2018 wrap-up ASI Newsletter december 2018

represented over 50% of plenary intended to support women to equity in our society, with talks (9/16) and chairs (28/54) attend annual ASI meetings who particular thanks to Su, Kim, and the committee achieved are the primary carer of one or Elissa and Chris. I’m proud of our equal representation among our more children of primary school achievements and am grateful for Australian/NZ invited speakers. age or younger. Thank you to our the opportunity to represent our judges and congratulations to our members on council. Furthermore, the Perth organising outstanding recipients for 2018, committee showcased ASI’s I also wish to express my who will tell you all about their wealth of talent amongst our early immense gratitude to the women conference experience in the next career researchers in stimulating who came before me, and want issue. symposia and workshops to particularly acknowledge sessions, the all-female BD On a personal note Ros Kemp and Barbara Fazekas Science Communication prize for establishing the WI, for the As my term as Women’s Initiative presentations and the high female continued support from senior Councillor ends and I now hand representation in this year’s and junior women in our society, over the role to Dr Kylie Quinn outstanding New Investigator the sustained and vocal support [Link: https://research.monash. session. Supporting gender and from Exec and council. edu/en/persons/kylie-quinn], I career diversity in our program take the opportunity to thank ASI I wish Kylie all the best in the role clearly supported great science! Exec and Council for supporting and look forward to exciting new Female speaker database the Women’s initiative and for initiatives to promote and support ASI’s commitment to gender our female members. Our female speaker database continues to grow, and the launch of a new ASI website next year will allow us to update the database and populate links to professional and social sites (Twitter, LinkedIn, Scopus etc) to enhance the representation of female immunologists as speakers at conferences, seminars, participants on review panels, and on editorial boards. The database is accessible to all visitors to ASI website, WI page and promoted on the IUIS website. We will be updating the database over the coming months to promote as a resource for female reviewers (including for our own ICB and CTI Journals), so please join if you haven’t already or email to update! Click here to check out the female speaker database on the ASI website.

Increased WI Travel Bursaries This year, ASI supported 4 travel awards (each up to $1000) to support travel of ASI women to attend our national meeting in Perth. The aim of these awards is to provide a more flexible approach to facilitate women with parental responsibilities to attend our society’s annual national meeting. The awards are

13 Women’s Initiative 2018 wrap-up ASI Newsletter december 2018

Gender equity and inclusion policy for speakers and session chairs at ASI events

Background to formalise this commitment and • (3) Women tend to be Gender equality is achieved support organising committee nominated by senior men less when people are able to access members to ensure that there frequently than equally qualified and enjoy the same rewards, is an equal representation of male colleagues men and women as committee resources and opportunities • (4) Women are more frequently members, speakers and session regardless of gender. To support unable to take up invitations chairs at all future ASI and ASI- the Australasian Society for than men, so to achieve equal sponsored events. Immunology’s commitment representation at the final to gender equity, ASI seeks Gender equity at ASI will have conference/symposium more to ensure that there is an the legacy effect of ensuring women need to be invited to equal representation of men that both females and males speak or chair and women as speakers and have equal opportunity of The approaches described below session chairs at all ASI scientific being acknowledged for their address each of these key factors meetings and symposia, etc.; and achievements, which will promote and will ensure that the ASI is at meetings financially supported emerging research leaders and proactive in ensuring gender by ASI. This visible display of an increased diversity of role equity at annual meetings and gender equity will contribute models in the Australian scientific symposia. to an equal number of females research community. Further, and males being acknowledged to support inclusiveness and Objectives for their achievements, provides diversity, this committee will seek This policy seeks: opportunities for emerging to ensure that students, early To achieve equal representation research leaders and increases career researchers and (senior) of males and females as speakers the diversity of role models academics from all backgrounds and session chairs at all ASI for meeting attendees. It is are encouraged to participate conferences, symposia, scientific anticipated that this practice in all aspects of the conference meetings etc; and at conferences will be adopted more broadly regardless of gender, gender supported by ASI. as one mechanism to address expression, sexual orientation, gender imbalance and differential ethnicity, nationality, disability, Scope and exclusions visibility in the medical research religion or age. This policy applies to all ASI sector. The underlying reasons for the symposia including conferences, In addition to the ASI annual current dominance of male symposia organised by members national scientific meeting, ASI speakers and chairs are: that is supported by ASI, state branches also hold annual financially or in-kind contributions meetings, as well as a number of • (1) Men continue to occupy the (including advertising). special symposia and affiliated most senior roles and therefore enjoy greater visibility Excluded from this policy are meetings each year for local affirmative action initiatives such members. ASI has made great • (2) Women tend to self- as the ‘Women Initiative’ events efforts, particularly in recent nominate less frequently than and awards that specifically seek years, to achieve gender equality equally qualified men to promote female members. at all meetings. This policy seeks 14 Women’s Initiative 2018 wrap-up ASI Newsletter december 2018

Procedure awards.’ This statement should be meeting, with final approval made 1. Initial information for included in any nomination forms. by the local organising committee organising committee This should be discussed and chair(s). Where gender equity noted in the minutes at organising balance has not been achieved, When planning begins for a committee meetings. the organising committee should new conference, the organising briefly document the steps that committee will be made aware 4. Selection of speakers from have been taken and note barriers of this policy via the Women’s nominees, abstracts and encountered and report to ASI Initiative Councillor and Meeting invitation of speakers council. co-ordinator or Local Councillor The organising committee is Local organising committees that (and previous conference encouraged to invite equal have completed their conference/ reporting, as outlined below). numbers of male and female symposia are encouraged to write This policy will also be widely invited speakers both national a brief report summarising the communicated within the society and international. The committee meeting that includes specific and published on the ASI and is advised to have a surplus of reference to performance in terms conference webpage to ensure female speakers on their list of of gender equity and inclusion. high levels of awareness. invitees, in case women invitees This could be accompanied by 2. Included information when are unable to accept invitations to summaries of any questionnaire requesting self-nomination speak. If a preponderance of men results collected, as stated below is nominated, a second round of When calling for self-nominations, – eg by conference organisers requests for female nominations the organising committee such as ASN events. This report should take place, and a proactive will include a statement to is to be forwarded to ASI effort should be made to find the following effect: ‘Please council and the succeeding ASI appropriate female speakers, to remember women tend to self- organizing committee. ensure gender equity in the final nominate less frequently than speaker list and session chairs. 6. Event evaluation men so every effort should be made to counter this tendency to All efforts will be made to ensure Where formal evaluation of ensure gender equity.’ This should selection of abstracts that result event participants is undertaken be noted in the minutes as having in oral presentations at national there should be a question been discussed at conference/ conferences and local meetings included regarding this policy, symposia organising committee have equal representation of such as: ‘Australasian Society for meetings. male and female speakers. Immunology 20yy is committed In addition, all efforts will be to ensuring diversity, such as 3. Included information when made to promote students and gender equity, among speakers requesting nominations early career researchers in both and chairs. Was this commitment When calling for nominations speaker representation as well adequately demonstrated at this for prizes or honorary roles as chairing and networking event? Did it have an impact on such as chairing of sessions, opportunities with more you as a participant?” the organising committee will senior delegates, through such 7. Monitoring include a statement to the initiatives as oral presentations following effect: ‘We strongly across conference sessions (by The Gender Equity and Inclusion encourage you to consider gender selecting either or both a student document is included as a equity in your nominations as, and early career researcher to downloadable file in all ASI in keeping with ASI’s policy, speak at each workshop and conference (and branch) we are committed to selecting symposium sessions) and social webpages. The ASI executive an equal number of male and events targeted towards ensuring council and WI councillor will female nominees as speakers and parity of access to networking monitor the outcomes achieved chairs and giving equal access to opportunities. and report annually to the succeeding conference organising 5. Checks when arranging final committee, with successive The organising committee is speakers and session chairs committees striving to achieve encouraged to invite equal Final lists of speakers and gender targets if not met. This numbers of male and female chairs should be circulated to document will be reviewed and invited speakers both national all members of the committee updated every 3 years. and international. to be endorsed at a committee

15 Meet the ICB Editorial Team ASI Newsletter december 2018

Meet the ICB Editorial Team Anne La Flamme, ICB Editor-in-Chief

We have now added another 10 Anne La Flamme, Editor-in-Chief Sammy Bedoui, Deputy Editor stimulating issues of Immunology - International and Society & Cell Biology to our library for Relationships 2018 and are looking forward to publishing our first issue in 2019. This year, ICB has exciting new publications in the pipeline including 3 new Special Features on primary immunodeficiencies, macrophages & wound healing, and memory; we will keep you posted! The publishing of these issues takes an enormous amount of effort from many people from authors to reviewers and publishers and all overseen by • BSc in Life Sciences from the • MBBS graduate from the the ICB Editorial Team. Thus, I Massachusetts Institute of Hannover Medical School would like to take this moment to Technology (MIT) followed by an in Germany and heads a thank all of those who have made MSc in Molecular Parasitology research laboratory at the 2018 such a successful year for and PhD in Immunoparasitology Doherty Institute for Infection ICB but especially the outgoing from the University of and Immunity in Melbourne, Editorial Team (Gabrielle Belz and Washington, Seattle. Australia. Adrian Liston) and Editorial Board • His current research focus is members. • She is a Professor in the School of Biological Sciences at Victoria on how dendritic cells and T It is now my pleasure to announce University of Wellington and cells interact during infections, and welcome the new Editorial leads the Multiple Sclerosis with a particular interest in Board members who will continue Research Programme at the deciphering how specific innate to maintain and highlight the high Malaghan Institute of Medical signals shape these interactions. quality research of our society Research. • This research has defined how members and international memory T cells protect the collaborators. We have recently • Her current focus is on host from bacterial infections expanded the Editorial Team translational research in through non-cognate functions, to better enhance our journal multiple sclerosis and in uncovering that these responses activities so let me introduce you particular, identification of are regulated through the to the team at ICB. innate immune targets during progressive multiple sclerosis. stimulation of inflammasomes within DC

16 Meet the ICB Editorial Team ASI Newsletter december 2018

James Harris, Deputy Editor Justine Mintern, Deputy Editor investigation of dendritic cell Special Features, Virtual Issues, Special Features, Virtual Issues, biology, understanding how to and Invited Content and Invited Content initiate immunity to tumours and infection and the use of cutting-edge nanotechnology to advance the design of effective vaccines.

Ian Parish, Deputy Editor International and Society Relationships

• BSc in Zoology from the • PhD at the Walter and Eliza University of Nottingham Hall Institute, Australia and in the UK and PhD in (fish) Postdoctoral Fellow at Harvard immunology at the University of Medical School (Boston, USA) the West of England, UK. and the Whitehead Institute for Medical Research (Boston, USA). • He has worked as a postdoctoral scientist at the Institute for • She heads the Vaccine Animal Health and Oxford Biology laboratory in the • B.Sc. (Hons) from the Australian University, University of New Department of Biochemistry National University followed by Mexico and Trinity College and Molecular Biology at the a PhD at the Walter and Eliza Dublin. University of Melbourne and Hall Institute in Melbourne. the Bio21 Molecular Science and • Since 2013, he has run the • He has worked at the Yale Biotechnology Institute. Rheumatology Group at School of Medicine and ANU, Monash University, and his • Justine’s research dissects and is currently a Senior interests are in autophagy, the molecular pathways Researcher at the Peter innate immunity and the involved in promoting effective MacCallum Cancer Centre in regulation of inflammation, immune responses. Ongoing Melbourne. particularly cytokine release by research projects include the macrophages and dendritic cells.

17 Meet the ICB Editorial Team ASI Newsletter december 2018

• Ian’s research focuses on the Colby Zaph, News & Commentary Editor. molecular and cellular pathways Editor • Simone has run the Editorial that limit T cell immunity in a Offices for both ICB and CTI range of contexts, including since 2010 and is central for co- during steady-state tolerance, ordinating the engine house of viral infection and tumour the journal. growth. He was the first to define the molecular signature Jessica Borger, Associate Editor of CD8+ T cell tolerance, Web Content and was thereby able to demonstrate that tolerance is transcriptionally distinct from CD8+ T cell exhaustion.

Ashraful Haque, News & • BSc Honours degree in Commentary Editor Biochemistry from the University of Saskatchewan and his PhD from the University of Pennsylvania working on CD4 T cell memory development during Leishmania infection.

• In his postdoctoral work he • Bachelor of Medical and studied the immune response Pharmaceutical Biotechnology against the parasitic whipworm (Hons) from University of Trichuris. South Australia and PhD from • Professor and Head of the University College of London. Mucosal Immunity and • She has worked at National Inflammation Laboratory in the Institute of Medical Research Department of Biochemistry (now Francis Crick Institute), • BA(Hons) in Natural Sciences and Molecular Biology at the University of Edinburgh, Peter at Cambridge University, UK Biomedicine Discovery Institute MacCallum Cancer Centre, (1997), followed by a PhD (2002) at Monash University. in microbial biochemistry and is currently a Postdoctoral (Salmonella pathogenesis) with • His research continues to focus Fellow at Monash University. on the cellular and molecular Prof. Gordon Dougan FRS at • Her research interests broadly mechanisms that control Imperial College, London. focus on investigating immunity and inflammation the signaling pathways of • After a first post-doctoral at mucosal sites, with new unconventional T cells and their research position at the London extensions into the epigenetic contribution to inflammation School of Hygiene & Tropical regulation of innate and in models of lung disease, Medicine, he moved to QIMR adaptive immune responses. Berghofer in Brisbane, Australia, investigating T cell memory to study T cell responses during Simone Farrer, Editorial Office and its dysregulation in parasitic infection. Manager immune disorders as well • BSc(Hons) at Monash University as interrogating signaling • He is an Associate Professor at and MSc degree at the pathways involved in B cell the University of Queensland University of Melbourne. development, activation and and an adjunct Associate function. Professor at the Queensland • She has extensive experience Institute of Technology and is both in editing and publishing In 2019, ICB has exciting new exploring T-cell differentiation through 18 years in editorial publications in the pipeline and blood-stage parasite roles at CSIRO Publishing including 3 new Special Features responses during malaria from 1991 to 2009 where she on primary immunodeficiencies, using single-cell genomics worked with several zoological technologies. and botanical journals as a macrophages & wound healing, Production Editor and Managing and memory; we will keep you posted! 18 2017 Jared Purton Award Recipient ASI Newsletter december 2018

2017 Jared Purton Award Recipient Dr Arabella Young, NHMRC CJ Martin Overseas Fellow [email protected]

also a wealth of innovative against cancer, I wanted to further science. Here, I am conducting understand the juxtaposition the overseas portion of an between anti-tumor immunity NHMRC CJ Martin Fellowship in and immunotoxicity in response the Sean N. Parker Autoimmune to cancer immunotherapies. In the Research Laboratory led by Bluestone lab, I generated novel Professor Jeffrey Bluestone. Jeff tumor models in autoimmune- has formed a group of dedicated prone mice that enable profiling individuals with a diverse of autoimmune and anti-tumor repertoire of skills to investigate immune responses to cancer the next-generation of CAR T immunotherapies, simultaneously. cells, understand the influence of This system provides improved site-specific immune tolerance to understanding of the kinetics cancer immunotherapies, identify and tissue specificity of cancer novel autoantigens in type 1 immunotherapy-induced irAEs, Arabella Young, 2017 Jared Purton diabetes and even run clinical the impact of irAEs on tumor Award Recipient trials with autologous Tregs in development, and an ability autoimmune disease. to assess which therapeutic strategies may inhibit irAEs Whether it was Mark Twain or Following completion of without impeding anti-tumor not, I emphatically agree that, my PhD, which targeted immunity (Young et al. Cancer “the coldest winter I ever spent immunosuppressive adenosine Immunology Research, 2018; was a summer in San Francisco”. to promote an immune response DOI:10.1158/2326-6066.CIR- Far removed from the Californian ideals that I grew up with (Baywatch, the O.C., California Gurls by Katy Perry), the University of California San Francisco Parnassus is predominantly shrouded in fog, but thankfully

Following completion of my PhD, which targeted immunosuppressive adenosine to promote an immune response against cancer, I wanted to further understand the juxtaposition between anti-tumor immunity and L to R: Fernando Guimaraes, Jim Allison and Arabella Young at the immunotoxicity in response to International Congress of Immunology 2016 held in Melbourne. cancer immunotherapies.

19 2017 Jared Purton Award Recipient ASI Newsletter december 2018

18-0487). Together, these preclinical models provide a platform to assess safety profiles for cancer immunotherapies, identifying cellular mechanisms and therapeutic interventions that inhibit the development of autoimmunity while preserving anti-tumor immunity.

In 2017, my research efforts were significantly bolstered as runner- up of the Jared Purton Award. I would like to express my sincere gratitude to Jared’s parents and ASI for the opportunity to represent Jared as a recipient of this award as well as for their ongoing support of young Presenting at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunologists. The generosity Immunotherapy Conference. from this award enabled me to establish a collaboration with the Schreiber and Artyomov laboratories at Washington with geneticists, oncologists University in St Louis to define and specialists in individual I would like to express my autoantigens and neoantigens organ system pathologies to sincere gratitude to Jared’s that are recognized during understand therapeutic response immunotherapy treatment, an and predisposition for irAEs. For parents and ASI for the essential step in understanding both stalwarts and newcomers opportunity to represent Jared immune cell regulation in to cancer immunotherapy, a as a recipient of this award as my newly generated models. clear highlight of this conference well as for their ongoing support In addition, I was able to was the announcement that of young Immunologists. showcase my research findings Professor Jim Allison, who was at the Fourth CRI-CIMT-EATI- in attendance, was awarded AACR International Cancer the 2018 Nobel Prize in Immunotherapy Conference in Physiology or Medicine (joint New York City. Here, Australia with Professor Tasuku Honjo). was strongly represented with This is the first time that the speakers Peter Savas and Clare Nobel Prize has been awarded Slaney from Peter MacCallum for an advancement in cancer Cancer Center, Jake O’Donnell treatment. While the growing from QIMR Berghofer and number of patients receiving myself all detailing our latest clinical benefit is validation of research findings. This was my the power of these therapeutic first opportunity to present modalities, this represented my preclinical irAEs model and a monumental milestone for it was met with a plethora of cancer immunotherapy. For collaborative opportunities me personally, it was an awe- to test the interconnectivity inspiring moment that would of autoimmunity and cancer not have been possible without immunity when challenged with support from the Jared Purton new therapeutic combinations. Award, an immense honor and I again thank Jared’s family for their This conference continues contribution to supporting the Presenting at the Fourth CRI-CIMT- to expand with the cancer EATI-AACR International Cancer development of my independent immunotherapy field appearing Immunotherapy Conference. research program at this early increasingly interdisciplinary as stage of my career. immunologists work in tandem

20 2017 Gordon Ada Senior Award recipient ASI Newsletter december 2018

2017 Gordon Ada Senior Award recipient- Katherine Kedzierska Catherine Somerville

Since receiving her PhD from It was working with Laureate Monash University in 2002, Professor Doherty that sparked University of Melbourne Professor her interest and enthusiasm for Katherine Kedzierska’s career has influenza research – she focussed been on an upwards trajectory, on the early establishment of including significant scientific influenza-specific CD8+ T cell discoveries, publishing close to memory, TCR repertoire diversity 130 peer-reviewed papers and and viral escape in a mouse model receiving some of Australia’s of influenza infection. leading scientific awards, “With a fantastic team, we did including the Australian Academy a lot of beautiful cutting-edge of Science Jacque Miller Medal in science, spent long days and 2016 and the Australasian Society nights in the lab, and Peter was for Immunology Gordon Ada always there within reach, in Senior Award in 2017. person or by emails, to share our Katherine’s research on experimental highs and lows,” understanding immunity towards Katherine remembers. pandemic, seasonal and newly “Peter was, and still is, the most emerged influenza viruses Professor Katherine Kedzierska wonderful and inspiring mentor. is internationally renowned, Through his scientific brilliance, spanning immunity in the young, University Mollie Holman Doctoral he not only taught us how to elderly, Indigenous Australians Medal. do research, but also shared his and patients hospitalised with pearls of wisdom on how to think severe influenza. But it all Now, she heads up a laboratory began at the Burnet Institute at the Peter Doherty Institute Peter was, and still is, the most in Melbourne where Katherine for Infection and Immunity worked with distinguished HIV (Doherty Institute) – a joint wonderful and inspiring mentor. clinician and researcher Professor venture between the University of outside the box, work in a group Suzanne Crowe AM. Katherine’s Melbourne and Royal Melbourne situation, ask key immunological studies proposed mechanisms Hospital, and named after questions and see where they of why HIV-infected patients Nobel Laureate, Professor Peter lead you, and then creatively write develop specific opportunistic Doherty. A man whom Katherine about them.” infections as their disease undertook her postdoctoral progresses. It was this research research with, ironically enough, “Sometimes I wonder what kind that earned her a Premier’s with the support of an NHMRC of researcher I’d become if I was Commendation for Medical Peter Doherty Postdoctoral not trained by Peter. And I know, Research and the Monash Fellowship. for sure that I would not be where

21 2017 Gordon Ada Senior Award recipient ASI Newsletter december 2018

making sure we are all learning Indigenous populations are and progressing. The track record more vulnerable to the newly of her previous students was emerged avian H7N9 influenza also something that attracted strain, that emerged in China in me to her lab - everyone was 2013, resulting in around a 35 per doing extremely well. She has an cent mortality and 99 per cent open door policy and somehow hospitalisation rates. manages to make time for “There are concerns that the virus everyone.” may mutate to allow human-to- Katherine’s recent findings on human transmission. Our group PhD student Mario Koutsakos with the vulnerability of Indigenous looked at the level of pre-existing Professor Katherine Kedzierska populations, including Indigenous killer T cell immunity to the new Australians, to influenza H7N9 virus and found that 16- I am now, doing research I love viruses have implications 57 per cent of the population doing in the way I am doing it.” for vaccine design and would have pre-existing T cells Katherine was able to establish development. Katherine is a to H7N9, however the prevalence her own research team after Co-Head of Indigenous Health at greatly varied across ethnicities,” being awarded an NHMRC RD the Doherty Institute. Katherine explained. Wright Fellowship and an NHMRC Her research has found “We found Caucasians might be project grant in 2007. She head’s up a team of four postdoctoral fellows, six PhD students and one research assistant in the Human T cell Laboratory at the Doherty Institute.

“One of the responsibilities of senior scientists is to supervise students, I don’t treat it as an obligation but as an exciting opportunity. It’s something I’m very passionate about and I’ve been incredibly privileged to have some very impressive young LET US DO ALL THE SEARCHING FOR YOU scientists in my lab previously, WE WILL GET YOU THE PRODUCT INFORMATION AND PRICE IN THE SAME DAY and now. They are the future and I take my teaching, guiding and supporting of them very seriously,” Katherine said.

PhD student, Marios Koutsakos approached Katherine to be part of her lab because of her expertise and reputation in the field of influenza immunology.

“I had the opportunity to chat to a former member of the University of Melbourne’s Department of Microbiology and Immunology who was visiting London where I was studying prior to moving to Melbourne, and they recommended Katherine to me as a great supervisor,” Mr Koutsakos said.

“As a lab head she is highly invested in all lab members,

22 2017 Gordon Ada Senior Award recipient ASI Newsletter december 2018 best positioned to fight the new cytokine storm in their lungs and “We can’t predict when or what H7N9 strain, while Indigenous severe or fatal influenza infection,” the next influenza pandemic will populations, including Indigenous Katherine described. be, but we can be as prepared as Australians and Alaskans, are possible, which is why my team “These data suggested that the most vulnerable to the newly and I are investigating possible early monitoring of inflammation emerged H7N9 influenza virus.” avenues to prevent severe together with IFITM3 sequencing influenza in people,” Katherine This genetic susceptibility is might allow the clinicians said. caused by allelic differences in to design early intervention the protein complex, named HLA, strategies for the treatment of “I think it’s entirely possible that essential to generate robust T cell severe H7N9 influenza.” within five to ten years as well responses. These findings also as having a universal vaccine at Katherine and her team are explain the high level of mortality our disposal, treatment for severe working hard on developing a observed in Indigenous adult influenza will have drastically universal, one-shot influenza Alaskans (100 per cent in some improved, using immunotherapy vaccine, that is, a vaccine that isolated villages) and Australians to fight the virus is just one will cover the strains of the flu (10-20 per cent) that occurred example. It’s an ever-changing that cause the most morbidity during the catastrophic Spanish area of research to be a part of and mortality and targeted at the 1918-19 influenza pandemic. and I’m really excited to see what populations who are affected the the next breakthrough will be.” This study, published in PNAS, most by influenza. has implications for vaccine development and delivery to protect Indigenous populations globally.

“If H7N9 spreads outside China, Indigenous populations need to be a priority for the vaccine delivery. It suggests a need for a vaccine tailored to the Indigenous populations,” Katherine said.

One of Katherine’s main collaborations is with Fudan University in Shanghai, where she is an Adjunct Professor, and a Co-Director of the Sino-Australia Joint Research Laboratory for the Emerging and Re-emerging Infectious Disease Research, Fudan-Melbourne University, located at the Shanghai Public Health Clinical Centre.

A project of particular note that stemmed from this collaboration is research with Professor Jianqing Xu in China that dissected the factors leading to severe and fatal avian influenza.

“We found that elevated levels of inflammatory cytokines/ chemokines early in the disease, linked to a defective variant of the protein IFITM3, can predict the disease outcome for H7N9- infected patients. People with the defective genetic IFITM3 variant are more likely to succumb to the

23 BRANCH REPORTS ASI Newsletter december 2018

branch reports

SOuth australia & northern territory Iain Comerford, out-going SA/NT Councillor

ASI Prizes for undergraduate immunology 2019 promises to be an exciting Immunology student at Flinders University was shared between Monica year in the branch as we are • The SA/NT ASI Hanson and Lauren Newman. hosting the annual conference branch sponsored in Adelaide on 8-12th December. the ‘ASI Prize for Well done to all of the award Immunology’ winners! The local organising committee ($200) at the University of South are actively putting together a 2019 ASI in Adelaide Australia, which was awarded diverse and vibrant scientific to the students who achieved 2019 promises to be an exciting and social program and we look the highest overall mark in year in the branch as we are forward to seeing you there. the Immunology course in the hosting the annual conference in School of Pharmacy and Medical Adelaide on 8-12th December. The local organising committee are Sciences. The 2018 winner was James McEvoy (student rep), actively putting together a diverse Emily Zotti. Elena Cavalero (student rep). If and vibrant scientific and social • The 2018 prize ($250) for top there are other members in the program and we look forward to branch who would like to help out seeing you there. please let us know! The local organising committee New state councillor are: Iain Comerford & Damon Tumes (co-chairs), Lisa Ebert This is my final year as state (secretary & sponsorship), Timothy councillor. Thanks to everyone in Sadlon (sponsorship), Danushke the branch who has helped out Wijesundara (co-treasurer), with all of the ASI activities over Preethi Eldi (co-treasurer), Simon the past 3 years and to everyone Barry (program subcommittee), on council for all of their help Antonio Ferrante (program and support. Dr Damon Tumes subcommittee), Claudine Bonder ([email protected]) has (social sub-committee), Patrick taken on this role going forward. I Hughes, Susan Pizzutto, Isaac am certain he will do a terrific job Sakala, Stanley Yu, Alex Quach, as state councillor and I wish him Toby Coates, Stephen Blake, all the best! Mohammed Alsharifi, Tessa Merry Christmas and all the best Lauren Newman and Monica Hansen Gargett, Tim Tyliss (student rep), for 2019! (Flinders Uni Prize Winners) Nikki Landsdown (student rep),

24 BRANCH REPORTS ASI Newsletter december 2018

New Zealand Ries Langley, NZ Councillor

This year has our winning speakers: Alana Speaker Program including Carina been a successful Whitcombe (Glenn Buchan Mallard (Auckland), Alan Sher one for the NZ (Buck) Award for best student (Dunedin, Wellington), Diane Branch. We had presentation), Evert Jan Loef Mathis (Wellington), Arne Akbar an increase in (Barbara Heslop Award for best (Wellington), Uri Hershberg membership post-doctoral presentation), and (Dunedin), and Joel Ernst with both the return of some old Jody Hazlett (John Marbrook (Dunedin). Many thanks to those members and the introduction of Award for best technician members that hosted speakers new membership. presentation). Catherine Tsai in their regions and those that won the challenging 3 Minute Those who attended the Branch attended VSP events. Presentation category sponsored meeting in Queenstown gave by Jomar Life Research. I look NZ will be hosting the ASI 2020 positive feedback about the forward to seeing everyone ASM and I am still happy to change of format for this year. at the 2019 Branch meeting in accept anyone interested in The NZ Branch gave out 30 travel Wellington. joining the organizing committee. bursaries (totalling $10,903.28) to student, post-doc, and technician We were fortunate to have many I wish you all a happy and relaxing members to attend the Branch excellent immunologists come summer break, and all the best for Meeting. We congratulate to NZ as part of the Visiting 2019.

Western Australia Connie Jackaman, out-going WA Councillor

This is my last ASI visiting speaker program very well received, although newsletter report (Ben Seddon, Muzlifah Haniffa, feedback suggests we should as WA branch Lars Nitschke, Cezmi Akdis, try a new venue for P.I.G. next councillor and it Mübeccel Akdis, Carina Mallard, time! has been a busy Arne Akbar and Uri Hershberg) We have also focussed on 3 years with as well as fantastic national supporting early career immunology speakers (Kate Schroder, Nick researchers and have awarded in WA! Over the last few years, Huntington, Axel Kallies, Su many ASI WA travel bursaries and our local branch has broadly Heinzel, Ben Marsland). prizes for students/early career focussed on building the profile postdocs throughout the years. of immunology in WA in the • Return of the local branch meeting, Perth Immunology lead up to the national scientific Over the last few years, our meeting recently held in Perth Group meeting (P.I.G) in local branch has broadly 2018. We have held 7-9 events/ October 2017, organisation year to engage with the local of an immunology-themed focussed on building the profile WA immunology community and session for the Combined of immunology in WA in the lead cross-promote the immunology Biological Sciences Meeting up to the national scientific in August 2018, sponsorship discipline across other fields and meeting recently held in Perth. societies. of the inaugural Pan-Sepsis Symposium and regular Highlights include:- participation in the ASCIA WA A big thanks to all of our local • Day of Immunology public Day of Immunology. P.I.G. is committee members for all their symposiums and lab tours next scheduled for 2019 and hard work and dedication to ASI (organised by the student sub- then CBSM again in 2020 WA over the last 3 years. I know committee). (alternating years between P.I.G Bree Foley will do a fantastic job and CBSM). The happy hour • Regular visits from international as the next WA branch councillor sessions at these events were visiting speakers through the and see you all at the next event!

25 BRANCH REPORTS ASI Newsletter december 2018

New south wales Helen McGuire, NSW branch Councillor

NSW ASI And as is always the case, our members along branch retreat cannot go ahead with our ACT without the solid support we colleagues receive from our sponsors, celebrated a for which we are greatly stellar NSW/ACT appreciative. Special thanks branch meeting hosted at Sebel to our sponsors, my fellow Harbourside, Kiama on the 13th councillor Ian Cockburn and our and 14th September. organising committee (below) with registration&website Ian “fixing” the projector Special thanks to our invited support from Tyani Chan and speakers: internationally Prof Uri Natalia Zych. Hershberg (Drexel University, Philidephila, PA, USA), nationally ASI ACT/NSW Branch Meeting Prof Mariapia Degli-Esposti (Lions Organising Committee Helen McGuire Eye Institute, The University of Ian Cockburn Western Australia), and locally Naomi Truong Prof Emad El Omar (UNSW) with Kirstie Bertram Prof Barbara Fazekas de St Groth Ron Sluyter (The University of Sydney) and Dr David Tscharke Pablo Silveira (ANZAC Institute) Alicia Wilson speaking in a special session Anne Bruestle dedicated to Derek Hart who was Scott Byrne a keen supporter of our branch Mainthan Palendira Celebrating Derek Hart in a meetings. Pablo Silveira dedicated session

We enjoyed an entertainment filled evening, with trivia, thanks to our Uni Syd ecrs and live music thanks to our Biolegend rep Kathryn Friend.

Taking in the sights at our Branch Meeting Venue, the Sebel Harbourside, Kiama

26 BRANCH REPORTS ASI Newsletter december 2018

Fabio Luciani Regarding the ASI Visiting Speakers Program, in addition to Uri as mentioned above whom attended our branch meeting, NSW benefited from a visit from Joel Ernst in October. Prof Warwick Britton hosted this visit at the Centenary Institute, including an interesting afternoon seminar. Prior to this, ASI sponsored a networking lunch with Joel and 7 student and early career ASI members.

Next year NSW is looking forward to hosting Bob Seeder in February and Donna Farber in August. Stay Joel Ernst presenting at the Centenary Institute tuned to hear about presentation dates and coordinated ASI networking events.

And finally, ASI NSW was delighted to support additional travel support to our junior members to attend ASI 2018 in Perth. Congratulations go out to: Students Get a clearer • Hui Chi Lai, University of NSW, NSW • Benita Ci Yin Tse, University of picture Sydney, NSW

• Lisa Worley, University of NSW, NSW

• Jessica Pedersen, University of Technology Sydney, NSW

• Postdocs

• Angelica Lau, Garvan Institute, NSW

• Anneliese Ashhurst, University of Sydney, NSW

• Felix Marsh-Wakefield, University of Sydney, NSW

We hope you enjoyed the wonderful conference experience.

Please feel free to contact me if you would like to get Used to high resolution? Your IHC images should be no different. more information or make any Our E Cadherin RabMab® antibody showed suggestions for upcoming events exceptional sensitivity compared to the ([email protected]. leading competitor. au). I’m always keen to hear the See more data at thoughts of ASI members. www.abcam.com/qualityvalidation

27 BRANCH REPORTS ASI Newsletter december 2018

Visiting Speaker Program updates Stuart Mannering

The up-coming 2. A/Prof Mirjam van der Berg regulation of immune responses. speakers, in from Leiden University Medical Kate was nominated by Joanna the ASI Visiting Centre. Mirjam’s group works Groom. Speaker Program on immune deficiency. She was 5. Dr Micheal Gerner, from are: nominated by Emily Edwards. the University of Washington. 1. Prof Bob Seeder, 3. Prof Joachim Schultze, from Micheal’s group study the micro from NIH. Bob works on the the University of Bonn. Joachim’s anatomy of immune responses development of vaccines for group use single cell sequencing and immune cell interactions. ‘hard diseases’ such as HIV, TB approaches to study macrophage He was sponsored by Cameron and malaria. Bob was nominated biology. He was nominated by Bastow. by Ian Cockburn and will visit in Stephen Turner. The speakers’ presentations will February 2019. At this stage his 4. Dr Kate Jeffery, from Harvard. be advertised locally closer to the itinerary is: Brisbane on Monday PerkinElmer Multimode Plate Readers - Select the one that’s right for your lab Kate’s group study epigenetic time of their visit. 18th of February, Canberra on PerkinElmer Multimode Plate Readers - Select theTHE one that’s NO-WASH right for your lab Tuesday 19th, in Canberra to THE NO-WASH VICTOR Nivo™ Multimode Plate Reader Melbourne on Wednesday 20th, ™ •VICTOR Compact, Nivolightweight Multimode and versatile for Plate multi-user Reader labs Lorne for the infection and PerkinElmer Multimode Plate Readers - Select theN THEoneO that’s -NO-WASHW rightA forS yourH lab • HighCompact, performance lightweight for routineand versatile applications,ELISA for multi-user biochemical labs and cell-based assays • AllHigh major performance detection for modes: routine Abs, applications, Lum,ELISATHE FI, FP, biochemical and NO-WASH TRF plus and optional cell-based dispenser assays and gas control immunity conference on Thursday ALTERNATIVETHE NO-WASH • EasyAll major to use, detection intuitive modes: browser-based Abs, Lum,ALTERNATIVE software FI, FP, and for convenientTRF plus optional remote dispenser control operationand gas control 21st, Melbourne Friday 22nd. He • Easy to use, intuitive browser-basedTHAT software TRANSFORMSfor convenient remote control operation FIND THE PERFECTBestVICTOR for research Nivo ™labs Multimode with multi-users,THAT Plate and ReaderTRANSFORMS relatively low-throughput assays. Best for research labs with multi-users,ELISA and relatively low-throughput assays. returns home on Saturday 23rd. FIND THE PERFECT FIND THE PERFECT• Compact, lightweight and versatileNNO-WASH ALTERNATIVEELISATHEfor multi-userO -NO-WASHW labs ASH FIT FOR YOUR• High performance LAB for routine applications,YOURELISAALTERNATIVE biochemical andLAB cell-based assays 2. Prof Donna Farber, from FIT FOR YOUR• All major LABdetection modes: Abs, Lum,YOURALTERNATIVETHAT FI, FP, and TRANSFORMS TRF plus optionalLAB dispenser and gas control FIT FOR YOUR• Easy to use, LAB intuitive browser-based software for convenient remote control operation ™ -Related Technologies THAT TRANSFORMS Columbia University. Donna works EnSight Multimode PlateELISA Reader

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Tonia Woodberry, he will visit For a complete listing of our global offices, visit www.perkinelmer.com/ContactUs

Copyright ©2017, PerkinElmer, Inc. All rights reserved. PerkinElmer® is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners. sometime in 2020. 013740_01 PKI 28 The IUIS corner ASI Newsletter december 2018

The IUIS corner J. Alejandro Lopez

Here is a brief update of the news coming from IUIS. If you wish to follow the news coming directly from the IUIS, visit the www.iuisonline.org and/or register for the Newsletter. You can also follow IUIS on Twitter: twitter.com/iuis_online

• Bosnia and Herzegovina – Association of Immunology in Bosnia & Herzegovina • Chile – Chilean Association of Immunology (ASOCHIN) • Ivory Coast – Society of Clinical and Biological Immunology of Côte d’Ivoire IUIS Council and Executive other Council positions, it will be membership voted on during the IUIS General • Kazakhstan – Kazahkstan Association of Allergology and The three-year term of the IUIS Assembly 2019. Clinical Immunology executive and Council members Immunopaedia is to be completed soon and the • Luxemburg – Luxembourg new council will be elected during Contributions are welcome Society for Allergology and the 17th IUIS General Assembly on for this forum allowing all Immunology Saturday, 19 October 2019, prior to immunologist to enhance their the IUIS 2019 Opening Ceremonies CV by supporting the teaching in Beijing, China. The roles of Vice- of immunology via this tool used president, Treasurer, Secretary in training courses across the and members to the Council will world. Visit the regularly renewed be voted on then. content at www.immunopaedia. org.za/. The vice-president Faith Osier (Kenya Medical Research Institute, Interviewee María Moreno There has been slow progress Kilifi, Kenya) will take the reins of discusses the role of attenuated in the organisation of IUIS 2019 the presidency. You can learn from Salmonella in the treatment of where a new management model her passion for immunology and cancer and physician Güenter has been implemented. This will her work on the development of Fröeschl discusses his experience be the first time in which the a malaria vaccine in this engaging with Tropical Diseases and IUIS itself takes a substantial TED talk delivered earlier this year. Immunology in developing role in the organisation of the countries. International meeting and some The representation of ASI to the teething issues have slowed down New member societies IUIS Council has also been voted the progression. The Scientific on and I am very humbled to have Currently totalling 83 member- Programme committee met in been elected for a new term as societies, the newest members of Beijing in November 9th and the ASI representative. I will be IUIS are: will soon make the preliminary nominated by the ASI and, with all • Algeria – Algerian Society of program available. iuis2019.org Immunology

29 travel REPORTS ASI Newsletter december 2018

TRAVEL reports

Keystone Symposia on B cells: Mechanisms in Immunity and Autoimmunity Dresden, Germany, June 17-21, 2018 Imogen Moran, Garvan Institute of Medical Research, Immunology Division E: [email protected]

In June this year I was fortunate to receive funding from ASI to attend the Keystone Symposia meeting on B cells: Mechanisms in Immunity and Autoimmunity in Dresden, Germany. This is the key meeting for the leaders in the B cell biology field and having studied B cells during both honours and my PhD was very excited to attend my first B cell Keystone. This was an excellent conference with some inspiring talks on unpublished work. Some of the presentations I most enjoyed were from Associate Professor Marion Pepper at the University of Washington on memory B cells in malaria infections and from Assistant Professor Gabriel Victora at the Rockefeller University on the germinal centre reaction in the recall response. Overall, I learnt much about my specific area of research, memory B cells, as well on broader aspects of B cell biology. I was given the opportunity to present my work on the re-activation of memory B cells in the lymph node in both a short talk and a poster. This opportunity resulted in many fruitful conversations leading to new research questions and The sights of Dresden experimental ideas to consider.

30 travel REPORTS ASI Newsletter december 2018

In addition to attending this conference, I also had the opportunity to visit two labs in the United Kingdom. Firstly, I visited the Weatherall Institute of Molecular Medicine at the University of Oxford. Here I was hosted by Dr Oliver Bannard and had an excellent opportunity to present my work to his lab, meet his lab members and see the institute facilities. Subsequently, I travelled to Cambridge to meet with Dr Michelle Linterman at the Babraham institute. I presented a seminar to the institute and met with many of her lab members to Presenting my poster at the Keystone conference discuss their research. Michelle was a wonderful host for my visit and along with these scientific discussions also involved a British afternoon tea of scones in the garden at the Babraham and dinner at high table at Churchill HOW CAN WE HELP YOU? We ARE Scientists, here to assist you... THE SCIENTIST! College with some of her lab members. “I need functional TLR data to support Overall it was a very valuable my publication” “I want to do a broad biomarker screen of serum samples” and rewarding trip and I would InvivoGen offers sensitive and selective sincerely like to thank ASI for reporter cell lines for TLR, NOD, RLR, CLR With the Raybiotech L2000 array, their funding support as this CDS, Sting and inflammasome. Get your researchers can simultaneously functional data and get published! detect 200 proteins in a single International Travel Award sample. allowed me to attend an excellent *SAVE 15% with code JLRREPORT conference and to make contacts *Save 15% with code JLRRAYBIO that will be invaluable in my future career. “I want to screen samples for autoantibodies” “High background in my ELISA is driving me The Krex Immunome nuts!” array consists of 1,600 fully functional proteins Eliminate cross- spotted on glass. reactivity with Candor LowCross Buffer *Save up to 20% with code JLRKREX *Save 20% with code JLRCANDOR I was given the opportunity to present my work on the “Are my cell lines contaminated with “How can I easily source tetramers with different peptides?” re-activation of memory mycoplasma?” B cells in the lymph node Get peace of mind with a PlasmoTest With QuickSwitch Tetramers from MBL, mycoplasma health check. Get rid of you can swap peptides with an easy in both a short talk and a mycoplasma fast and definitively with 1-day protocol. Plasmocin and Plasmocure from InvivoGen. poster. This opportunity *Save up to 20% with code JLRMBL resulted in many fruitful *SAVE 15% with code JLRCLEAN conversations leading to new research questions and experimental ideas to JOMAR LIFE RESEARCH [email protected] consider. *promo codes expire 31/12/18. Not combinable with other offers or institutional pricing 1 300 543 373 www.Jlresearch.com.au

31 travel REPORTS ASI Newsletter december 2018

TOLL 2018: EDITING INNATE IMMUNITY June 6-9, 2017, Porto, Portugal KAIWEN CHEN, Inflammasome Lab, Institute for Molecular Bioscience, The University of Queensland & Department of Biochemistry, University of Lausanne, Switzerland E: [email protected]

Remarkably, this new antagonist presented a new Caspase-1 potently inhibits STING-mediated termination mechanism during inflammatory response in both inflammasome signaling that was human and murine cells, and very well received by the scientific also blocks STING-mediated community. autoinflammatory disease in During the course of the meeting, mice. Another standout talk I was very fortunate to meet up was from the cell death expert, with friends and colleagues that Vishva Dixit of Genetech USA, I have made during my time in where he dissected the functions Australia. I also had the chance of LUBAC in regulating cell to catch up with my PhD advisor death and embryogenesis. Kate Schroder, and my current Lastly, Kate Schroder from IMB supervisor Petr Broz where we discussed ideas for collaboration. After the meeting, I spent the After the meeting, I spent the Aerial view of the Congress Center weekend in Porto where I visited weekend in Porto where I visited of Alfandega and the Duoro river Livraria Lello Porto book store Livraria Lello Porto book store in Porto. which inspired the Harry Potter’s which inspired the Harry Potter’s library in Hogwarts! Overall, I am library in Hogwarts! Overall, I am extremely grateful to ASI for this I am extremely grateful to receive extremely grateful to ASI for this wonderful opportunity to attend an ASI Postdoctoral Travel Award, wonderful opportunity to attend the Toll meeting and to maintain which enabled me to participate the Toll meeting and to maintain my relationship with Australian in one of the largest and most my relationship with Australian immunology research. important innate immunity immunology research. conference series – The Toll 2018 meeting. The Toll conference series started back in 2004 and is held every 3-4 years at various fantastic locations. This year’s Toll meeting was no exception, and was held at the Congress Center of Alfandega, along the beautiful Duoro River of Porto, Portugal, home of the famous Port wine (picture below).

The Toll 2018 meeting featured a number of international renowned speakers and showcased recent advances in innate immunity and cell death. A particular standout talk was from Andreas Ablasser of EPFL, Switzerland, where she described a small- molecule inhibitor that potently and specifically antagonizes Kate Schroder giving a talk on Caspase-1 termination mechanism. the cGAS-STING pathway.

32 travel REPORTS ASI Newsletter december 2018

5th European Congress of Immunology Amsterdam, September 2-5, 2018 Ann Ly, Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research E: ly@wehi.edu.au

In September, I had the infections including HIV-1, and opportunity to attend the from Antonio Lanzavecchia, about European Congress of his ground-breaking research Immunology held in Netherlands. on monoclonal antibodies in I was welcomed to Amsterdam individuals exposed to malaria. I by sunshine and blue skies—a was fortunate enough to present perfect escape from the chilly my work on B cell responses to weather of Melbourne at the time. malaria infection in the poster The congress took place at the session on the last day, where I RAI Amsterdam Exhibition and had some interesting discussions Convention Centre, which was a with researchers of diverse very large complex; despite all the immunology backgrounds and signage, it took a bit of time to received useful feedback. navigate! The congress covered a Congress venue at the RAI Amsterdam Exhibition and After the congress, I visited spectrum of immunology topics, Convention Centre a few labs around Europe to ranging from molecular regulation discuss potential post-doctoral of immune cell differentiation opportunities. It was definitely an to vaccine development, with a eye-opening experience to visit Of particular interest to me particular emphasis on bridging some internationally renowned were the sessions on humoral fundamental and translational research institutes and build immunity and its regulation in research. It was a great professional connections which I infectious diseases. Inspiring talks opportunity to gain insight into hope to maintain throughout my were delivered in the sessions emerging, novel research areas future career. that were relevant to my work dedicated to germinal centre and also of general interest to me. responses, which involved the The opportunity to attend an presentation of novel models international conference and visit Each day involved a number and various omics approaches to various labs as part of my PhD was an invaluable experience, and The congress covered a spectrum explore the processes of B and T cell differentiation, and studies I am extremely grateful to ASI, as of immunology topics, ranging on the molecular dynamics of this would not have been possible from molecular regulation of memory generation. Another without the support of the ASI immune cell differentiation to interesting theme centred International Travel Award! vaccine development, with a around immune modulation particular emphasis on bridging during infection, exploring how fundamental and translational pathogens can regulate the fine balance between protective and research. pathogenic immune responses in the host, extending results from in of parallel keynote lectures, vivo models to human settings. symposia and smaller workshops on diverse topics. The opening It was an exciting opportunity to ceremony on the first day kick- hear from some of the pioneers started with an immunology trivia of modern immunology from quiz that was both entertaining Europe, but also those from other and engaging- especially as it international locations including was live-streamed across two Australia. Highlights included theatres and required efficient hearing from Florain Klein on the use of the congress app via our therapeutic potential of broadly Westermarkt, Amsterdam smartphones. neutralizing antibodies to viral

33 travel REPORTS ASI Newsletter december 2018

Gordon Research Conference on Protein Processing, Trafficking and Secretion New London, America, July 15 - 20, 2018 Natalie Borg, Monash University, Department of Biochemistry & Molecular Biology, Immunity and Infection Laboratory E: [email protected]

I left the bleak Australian Winter to attend the Gordon Research Conference on Protein Processing, Trafficking and Secretion held in New London during the American Summer (July 15 - 20, 2018). This meeting of around ~115 people was focused on the cell biology of the secretory and endocytic pathways, with an emphasis on human health and disease. This conference, chaired by Klaudia Brix, sure did not disappoint. The location, set in the beautiful surrounds of Colby-Sawyer College, made for a relaxed atmosphere. This combined with the enthusiasm and expertise of the attendees made for an inspirational and vibrant Natalie Borg spending a pleasant afternoon at Pleasant Lake. Photo by Ashley Buckle. conference that I thoroughly enjoyed.

Gordon Conferences are presentations of Timo Müller enzyme that has implications renowned for their quality, and (Helmholtz Zentrum München, for drug development. In that this, my first Gordon Conference, Germany), Irit Sagi (Weizmann regard, another highlight was a lived up to its expectations. My Institute of Science, Israel), Daniel general discussion put together personal highlights were the Kirchhofer (Genentech, USA) and by Nabil Seidah (Institut de fellow Aussie Christopher Overall Recherches Cliniques de (University of British Columbia, Montréal, Canada). Nabil put Canada). Each of these talks forward a clever and valuable were focused on target enzymes summary of retrospective lessons of the secretory pathway, but learnt from past drug discovery strikingly had something else in approaches that should guide Each of these talks common. They were an absolute future therapeutic approaches. were focused on target tour de force, highlighting the Following a discussion with Nabil enzymes of the secretory journey, investment, and breadth afterwards, I was humbled by his pathway, but strikingly had of techniques (e.g. cell biology, willingness to share both his time something else in common. genetics, structural biology) and expertise. required to turn discoveries Overall, I was impressed by the They were an absolute into drugs. These talks were approachability and accessibility of tour de force, highlighting simply mind-blowing and had the delegates. It was remarkably the journey, investment, implications for cancer, heart easy to spark a conversation at this disease, immunodeficiency, and breadth of techniques conference and there certainly was obesity and diabetes. required to turn discoveries some interesting discussion both into drugs. I myself presented unpublished during the sessions and afterwards work on the trafficking of an – not to mention some light-

34 travel REPORTS ASI Newsletter december 2018

Natalie Borg in front of one of the beautiful buildings that constitute Colby-Sawyer College. Photo by Nathan Lewis.

hearted fun when speakers went overtime and became contenders for the illustrious Golden Toilet Seat Award. The balance between the sessions and breaks was also spot on. New London certainly has some beautiful lakes, such as Lake Innovative products that make ChIP successful Sunapee and the aptly named Find the right ChIP kit for your research! Pleasant Lake, hidden gems worth visiting.

I am honoured to have received a Gordon Ada Senior Travel Award and would like to thank the ASI for supporting my travel to foster my career. The benefits were many, but chiefly afforded me an opportunity to enhance my international profile, make valuable new contacts in the field, and think about research questions from a different and much wider perspective.

These talks were simply mind-blowing and had implications for cancer, heart disease, immunodeficiency, obesity For details on each chip kit, please visit and diabetes. www.activemotif.com

35 travel REPORTS ASI Newsletter december 2018

17th Meeting of the Society for Natural Immunity (NK2018) San Antonio, TX, USA, May to 1st of June Fernando Souza Fonseca Guimaraes, Molecular Immunology Division, The Walter & Eliza Hall Institute of Medical Research E: [email protected]

presenting exciting insights on were started with international this cellular topic, not only in scientists after networking during cancer immunotherapy but also the meeting. in viral and bacterial infection, After the meeting, I was invited pregnancy, autoimmunity, cell to give seminars while visiting biology and other contexts. In the Memorial Sloan Kettering my opinion, this conference Cancer Center (MSKCC) in New demonstrated that research York (host: Prof. Joseph Sun) and in this topic is still expanding as we have now discovered After the invited seminar at the new functions of this immune Eminent scientists presenting Dana Farber Cancer Institute in cell type that go beyond their exciting insights on this cellular Boston (host DR. Lucas FErrari (left) de andrade, on behalf of the immunological role. topic, not only in cancer Wucherpfenning lab). The famous The benefits to have participated immunotherapy but also in statue in the netrance of the cancer centre, represents the founder to this meeting were limitless. I viral and bacterial infection, of the institute (dr. Sidney Farber, had an opportunity to present my pregnancy, autoimmunity, cell MD), and one of his early leukemia projects and data to world leaders patients (the 12 year old einar biology and other contexts. gustafson), to reflect their historic in the field, such as Professors relationship. Lewis Lanier (USA), George Leclerc (Belgium), Nadia Guerra the Dana Farber Cancer Institute (UK), etc. 5 new collaborations in Boston (host: Dr. Lucas Ferrari I received the ASI Travel Award de Andrade, on behalf of the to attend the 17th Meeting of the Wucherpfennig Lab), where I also Society for Natural had the opportunity to showcase my work and expand my visibility Immunity (NK2018) that took and collaborative network place in San Antonio, TX, USA with other immunologists during 28th May to 1st of June, outside the NK cell field. All 2018. The meeting was held at the new concepts/update and the Hyatt Regency Hill Country collaborative networks will Resort’s conference centre and provide me excellent resources joined the world experts in all to develop cutting edge projects the aspects of Natural Killer (NK) within Australia. WEHI (the research. Huntington Laboratory) and NK cells have recently emerged Monash University were the only as a new relevant field in cancer institutions to have researchers immunology, and currently representing Australia, and the demonstrate its potential concepts/contacts I’m bringing in tumour immunotherapy back will be of great value according promising clinical trials for many of the laboratories I results. The organizing committee After the invited seminar at the collaborate with here. composed by Emily Mace, Jordan MSKCC in new york (host: Prof. Joseph SUn). The picture at the I’m grateful for ASI to help me to Orange, Silke Paust, Katy Rezvani entrance of MSKCC represents the have this priceless international and Krishna Vankayalapati had put renomed prof. harold varmus, networking opportunity. Please american nobel prize-winning together a wonderful scientific don’t hesitate to contact me if any scientist in oncology. program with eminent scientists other information or document is necessary for this application. 36 sponsor publications & products ASI Newsletter december 2018

Publications of Interest Our Sustaining Members

Anti-CD11b antibody [EPR1344] (ab133357) RabMAb https://www.abcam.com/cd11b-antibody-epr1344-ab133357.html

Chen et al. (2018) SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.

Nature, DOI: 10.1038/nature22076

Anti-FANCD2 antibody [EPR2302] (ab108928), RabMAb, KO Validated https://www.abcam.com/fancd2-antibody-epr2302-ab108928.html

Richardson et al. (2018) CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway

Nature genetics, DOI: 10.1038/s41588-018-0174-0

Anti-NEK7 antibody [EPR4900] (ab133514) RabMAb, KO Validated https://www.abcam.com/nek7-antibody-epr4900-ab133514.html

Zhong et al. (2018) New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Nature, DOI: 10.1038/s41586-018-0372-z

37 sponsor publications & products ASI Newsletter december 2018

ChIP-IT Express Kit

Song J, et al. Aug 24 2018. Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Nature Communications.10.1038/s41467-018-05787-0 Summary: The ChIP-IT Express Kit was used to examine the status of H3K4me3, a mark associated with active gene expression, on the PGAM1 promoter via ChIP qPCR. With increased PGAM1 expression, they also saw increased expression of IL-1B and increased apoptotic cell death. Elucidation of this mechanism provides potential targets for controlling cartilage-degrading disorders.

Antibodies for histone modifications H3K4me3, H3K27me3, and H3

Suzuki J, et al. Aug 17 2018. The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation. Nature Communications. 10.1038/s41467-018-05854-6 Summary: Antibodies for these histone modifications were used in immunoblotting experiments to support the claim that demethylation of histone H3K27 is involved in CD8 T-cell dysfunction.

ChIP-IT High Sensitivity

Chan HL, et al. Aug 23 2018. Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms. Nature Communications. 10.1038/s41467-018- 05728-x Summary: The ChIP-IT High Sensitivity Kit was used with two breast cancer cell lines to enrich for RING1B, which is overexpressed in breast cancers. ChIP-seq libraries were constructed, and genome-wide binding of RING1B was analyzed.

EasySep Human CD4+ T Cell Isolation Kits

EasySep Human CD8+ T Cell Isolation Kits

EasySep Human PE Selection Kit

Salter et al. (2018). Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function. Science Signaling. doi: 10.1126/scisignal.aat6753

EasySep™ Human B Cell Isolation Kit

EasySep™ Mouse B Cell Isolation Kit

Yu et al. (2018). Complex interplay between epitope specificity and isotype dictates the biological activity of anti-human CD40 antibodies. Cancer Cell. doi: 10.1016/j.ccell.2018.02.009

THP1-Lucia™ NF-κB Cells (https://www.invivogen.com/thp1-lucia-nfkb) Polari et al. (2018) SERMs Promote Anti-Inflammatory Signaling and Phenotype of CD14+ Cells. Journal of Inflammation. DOI: 10.1007/s10753-018-0763-1

38 sponsor publications & products ASI Newsletter december 2018

HEK-Blue™ IFN-α/β Cells (https://www.invivogen.com/hek-blue-ifn-ab) Olagnier et al. (2018) Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Nature Communications. DOI: 10.1038/s41467-018-05861-7

RAW-Blue™ Cells (https://www.invivogen.com/raw-blue) Pizzuto et al. (2018) Cationic lipids as one-component vaccine adjuvants: A promising alternative to alum. Journal of Controlled Release. DOI: 10.1016/j.jconrel.2018.08.020

Knock-in mice (https://www.ozgene.com/services/knock-in-mice) Williams et al. (2018). Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports. doi: 10.1038/s41598-018-31957-7.

Knockout mice (https://www.ozgene.com/services/knockout-mice) Pandey et al. (2018). CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. PLoS One. doi: 10.1371/journal.pone.0203952.

Knockout mice (https://www.ozgene.com/services/knockout-mice) Drareni et al. (2018). GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Reports. doi: 10.1016/j.celrep.2018.08.032.

39 Australasian Society for Immunology ASI Newsletter december 2018

Australasian Society for Immunology Inc.

The aim of the ASI is to encourage ASI Council and support the discipline of immunology in the Australia and Executive New Zealand region. President – John Fraser [email protected]

The Australasian for Immunology Past President - Susanne Heinzel [email protected] Incorporated (ASI) was created Honorary Secretary - Elissa Deenick [email protected] by the amalgamation in 1991 Treasurer - Asolina Braun [email protected] of the Australian Society for Immunology, formed in 1970, Voting Council and the New Zealand Society NSW Councillor – Helen McGuire [email protected] for Immunology, formed in 1975. It is a broadly based SA/NT Councillor – Damon Tumes [email protected] society, embracing clinical QLD Councillor - Sumaira Hasnain [email protected] and experimental, cellular and VIC/TAS Councillor - Scott Mueller [email protected] molecular immunology in humans and animals. The Society provides ACT Councillor – Anselm Enders [email protected] a network for the exchange of NZ Councillor - Ries Langley [email protected] information and for collaboration within Australia, New Zealand and WA Councillor – Bree Foley [email protected] overseas. ASI members have been Non-voting council prominent in advancing biological and medical research worldwide. General Manager – Tyani Chan [email protected] We seek to encourage the study Facebook + Twitter Manager - Gabriela Khoury [email protected] of immunology in Australia and Newsletter Editor – Angelica Lau [email protected] New Zealand and are active in introducing young scientists to IUIS Representative - Alejandro Lopez [email protected] the discipline. ICB Editor-in-Chief - Anne La Flamme [email protected] CTI Editor-in-Chief – Rajiv Khanna [email protected]

ASI Member Benefits include: FIMSA Representative – Joanna Groom [email protected] • International Travel Awards Visiting Speaker Program – Stuart Mannering [email protected] • Bursaries to attend ASI’s Annual Women’s Initiative Co-ordinator – Kylie Quinn [email protected] Meeting Meeting Co-ordinator – Antje Blumenthal [email protected] • New Investigator and Student DoI coordinator - Gabriela Khoury [email protected] Awards at ASI Annual Meeting Honorary Archivist - Judith Greer [email protected] • ASI Women’s Initiative to Facebook and Twitter manager – Gabriela Khoury [email protected] support female scientists • ASI Member’s benefits 2019 LOC Meeting Co-Chair – Iain Comerford [email protected] publishing in ASI Journals ICB 2019 LOC Meeting Co-Chair – Damon Tumes [email protected] and CTI • Special offers from ASI’s Sustaining Members • Full access to the journals To join the ASI or renew your subscription, go to Immunology and Cell Biology, http://www.immunology.org.au/membership/ Clinical and Translational Immunology

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