DOCSLIB.ORG

Macfarlane Burnet Centenary Symposium on Immunology and Virology 3–5 August, 1999, Melbourne, Australia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Macfarlane Burnet Centenary Symposium on Immunology and Virology 3–5 August, 1999, Melbourne, Australia Laboratory Animal Science Vol 49, No 5 Copyright 1999 October 1999 by the American Association for Laboratory Animal Science Meeting Report Macfarlane Burnet Centenary Symposium on Immunology and Virology 3–5 August, 1999, Melbourne, Australia Abigail L. Smith This meeting was one of several events in Australia to cel- edict from WEHI that urged its scientists to work on flu or ebrate the centenary of the birth of Sir Frank Macfarlane leave the institute, he began an illustrious career as an in- Burnet, fondly known as Sir Mac by his friends and col- fluenza specialist. He elucidated the nature of receptor-de- leagues. The meeting was held in Melbourne during the stroying enzyme, began to characterize the nature of week prior to the XIth International Congress of Virology in reasssortment, predicted that influenza would have a seg- Sydney. Another centenary symposium, “Q fever - An Aus- mented genome, and pioneered the use of embryonated eggs tralian discovery of worldwide importance,” will be held as substrates for vaccine production. Ada then spoke about later in the year in Brisbane, and the July 1999 issue of Mi- the major diseases in the contemporary world (HIV, malaria, crobiology Australia, the journal of the Australian Society chlamydia) and the approaches that are being used to de- for Microbiology, was published in Burnet’s honor. Sir Mac velop vaccines. In these latter initiatives, he stressed the util- won the Nobel Prize in physiology and medicine in 1960 for ity of animal models. his hypothesis of immunologic tolerance, a phenomenon that Michael Alpers (Director, Papua New Guinea [PNG] In- was experimentally validated by Peter Medawar, with whom stitute of Medical Research, Goroka) began his talk by say- he shared the Prize. Ironically, Burnet is best known for his ing that Burnet had a “love-hate relationship” with kuru. work on clonal selection. Carleton Gajdusek, the acknowledged authority on kuru Burnet received his medical degree from Melbourne Uni- and himself a Nobel laureate, was a postdoctoral fellow in versity in 1922 and was director of the Walter and Eliza Hall the Burnet laboratory. Alpers talked about PNG-based stud- Institute (WEHI) in Melbourne from 1943–1965. Despite his ies of kuru and malaria, the former stressing epidemiology many contributions to the disciplines of microbiology (Q fe- and the latter stressing vaccine development with the goal ver) and virology (lysogeny in bacteriophage; Australian X of protection against severe, lethal malaria, not infection disease, now known as Murray Valley encephalitis), Burnet prevention. When transumption was recognized in the 1950s transformed the WEHI into an institute that stressed im- as the primary and perhaps only mode of transmission of munology. The Macfarlane Burnet Institute was established kuru, the practice was banned. This year is predicted to be one year after his retirement as director. the first with no cases of kuru, a disease with a 40 year incu- Having gained international recognition, Burnet was in- bation period. vited to deliver the Dunham Lectures at Harvard University Sir Gustav Nossal (Emeritus Professor, The University of in 1944. He was later offered a chair at Harvard but declined Melbourne) introduced Frank Fenner (Emeritus Professor, and was fiercely dedicated to Australian science. Sir Mac The John Curtin School, Canberra), well known to the labo- was knighted in 1951, was the founding president of the ratory animal medicine community for his pioneering work Australian Society for Immunology in 1959, and was named with ectromelia virus. Nossal told the audience that Profes- Australian of the Year in 1961. Speakers at the symposium sor Fenner, whose career has spanned 55 years, was Sir included colleagues and protégés of the honored scientist. All Mac’s favorite protégé. Fenner then spoke of his Burnet “con- speakers and topics are listed; however, space limitations nection” — he joined Burnet at WEHI in early 1946, remain- prevent detailed accounts of all presentations. ing until 1952 when he joined the faculty at the “nascent” Gordon Ada (Emeritus Professor, The John Curtin School, John Curtin School. Fenner then noted that the symposium Canberra) recalled that Burnet was about half way through honored Australia’s “greatest biologist,” a scientist who his medical studies when the influenza pandemic hit never put his name on a publication without having made a Melbourne. Burnet had a mild case, but was struck by the real contribution to the work reported. Fenner summarized enormous impact of the epidemic. In 1943, as a result of an the history of attempts to control rabbits, introduced to Aus- tralia in 1859 for sport hunting and, ultimately, very suc- Department of Pathology, Loyola University Medical Center, Brookfield Zoo, cessful pests. In 1888, a 25,000 pound prize was offered for Chicago Zoological Society, Chicago, Illinois control of the rabbit population. Even Louis Pasteur com- 471 Vol 49, No 5 Laboratory Animal Science October 1999 peted, but no one was awarded the prize. A colleague of (MV), the first virus shown to have immunosuppressive ca- Burnet’s suggested myxoma virus as a possible “temporary pabilities. The host cell receptor for LCMV and other control” agent; however, there was resistance to the proposal arenaviruses has been identified as ␣-dystroglycan, a because it was not known at that time whether the virus in- heavily glycosylated protein expressed on the basal side of fected humans. After many false starts, largely due to the cells. Clone 13, an immunosuppressive variant of LCMV, tar- fact that mechanical transmission by insects was not appre- gets interdigitating dendritic cells based on in situ hybrid- ciated, the potential of biological control was recognized. The ization studies; however, expression of very little detailed history of that effort was recounted and the devel- ␣-dystroglycan is sufficient to initiate infection. The clone 13 opment of host-determined genetic resistance noted. The virus-receptor interaction is high affinity: expression of 100- conclusion: myxoma did control, but not eradicate, rabbits. fold more ␣-dystroglycan is required for infection by the Jacques Miller (Emeritus Professor, WEHI, Melbourne) Armstrong strain of LCMV. Limited numbers of changes in talked about “biological curiosities.” Prior to 1961, the role of amino acid sequence have been shown to affect the affinity the thymus in immunity was not appreciated — thymec- of binding of LCMV strains and variants. Immunosuppres- tomy of adult mice had no effect and thymus cells were inca- sive consequences may be related to the same amino acid pable of transferring immunity. Miller showed the effect of sequences. Oldstone emphasized that there has not been, thymectomy immediately after birth in 1961 and demon- until now, a good small animal model of MV infection, de- strated in 1962 that there were two types of lymphocytes. In spite the fact that Von Pirquet documented the immunosup- 1972, Sir Mac called Miller’s subjects, mice that had been pressive capacity of this virus in 1890. The World Health thymectomized and sublethally irradiated, “biological mon- Organization has targeted MV for eradication by the year strosities.” But the ultimate importance of the thymus was 2015. The virus currently kills 1 million people per year and shown by Zinkernagel in 1978: MHC restriction is imposed infects 40 million people per year. Immunosuppression, aver- intrathymically. aging 2 to 3 months in duration, can result from infection. Peter Doherty (Professor and Chair of Immunology, St. The CD46 molecule is the host cell receptor for MV, and mice Jude Children’s Research Hospital, Memphis) quoted Bur- transgenic for CD46 may be infected by MV intracerebrally, net: “Science to me is the finest sport in the world.” Noting intravenously, or intraperitoneally. Virus recovery may be that Sir Mac led WEHI out of virology and into immunology, accomplished by co-cultivation. Additionally, MV infection of Doherty quipped “We all make mistakes.” He then discussed CD46 transgenic mice results in suppressed antibody re- his own current studies with the type 2 herpesvirus of voles, sponses to sheep erythrocytes, depressed primary cytolytic MHV-68, an agent taxonomically related to herpesvirus responses to vaccination and secondary responses to LCMV, saimiri, human herpesvirus-8, and Epstein Barr virus and enhanced susceptibility to Listeria monocytogenes after (EBV). The virus is lytic for epithelium, with primary repli- the sixth day of MV infection. Newborn CD46-transgenic cation occurring in respiratory epithelium, and remains la- mice infected with MV die, whereas adult transgenic mice tent in B cells and macrophages. Co-cultivation is necessary are immunosuppressed for an as yet undefined interval and for recovery of the agent from those cell types. As is the case die only if their immune systems are suppressed by a sec- for EBV, MHV-68 infection results in an increased number of ondary mechanism. This small animal model shows promise CD8+ T cells in peripheral blood. The facts that class II in facilitating our understanding of MV biology. knock-out mice die from MHV-68 infection and that anti- Colin Masters (Professor, Department of Pathology, Uni- body has been shown to be important in reactivation imply versity of Melbourne) spoke of “Mad Cows to Demented that all components of the immune system are necessary to People” in place of Stanley Prusiner. He discussed the simi- clear this virus, a potential animal model of EBV infection. larities and differences among Huntington’s disease, Doherty, while serious in dealing with the science, quipped “I Parkinsons’ disease, Alzheimer’s disease, and Creutzfeld- think of myself as part of the living fossil record;” as always, Jacob disease. Creutzfeld-Jacob disease occurs sporadically he had words of encouragement for young scientists in the in 10% of cases and is familial in 90% of cases. Despite the audience, noting that there is still plenty of work to be done. lack of evidence for blood-borne transmission of so-called Rolf Zinkernagel (Professor and Chair of Experimental “new variant” Creutzfeld-Jacob disease, the U.S.
Load more

Recommended publications
  • The Global Eradication of Smallpox and the Work of Frank Fenner
    In Focus The global eradication of smallpox and the work of Frank Fenner CR Robert George and William Rawlinson Virology Division, SEALS Microbiology Prince of Wales Hospital Randwick, NSW 2031, Australia Email: [email protected] The 1950s and 1960s represented a golden era in scientific poxvirus research. Multiple obituaries document his life, achieve- – discovery when many believed science would solve the ments, and his death in November 20102 10. world’s greatest problems. It was the era when colour tele- A DNA virus called variola (Orthopoxvirus, Poxviridae) causes vision was introduced and the role of DNA described, space smallpox. Case fatality rates varied depending on the infection type, programmes, the introduction of vaccines for polio, measles reaching up to 30% in the historically most common form variola and mumps, and the structures of proteins began to be major11. Smallpox has influenced the course of history and deci- described. Many discoveries were controversial, but there mated populations. For example, historians have debated whether was a strong belief science was taking the world forward and up to one-third of the Aztec population was decimated by smallpox reducing medical problems rapidly. The Intensified Small- in 1520 after Hernando Cortes accidently introduced the virus thus pox Eradication Program (ISEP) won united support from facilitating the European conquest of South America12. Elsewhere, both the Union of Soviet Socialist Republics (USSR) and the native Virginian inhabitants were depopulated to one-third of their United States of America (USA). The initiative was passed by former number in 1689, and numerous North American tribes were only a small margin (two votes) and came on the back of affected13.
    [Show full text]
  • Picture As Pdf Download
    MJA Centenary — History of Australian Medicine A history of health and medical research in Australia Timothy Dyke ealth and medical research has signifi cantly con- BVSc, PhD, MBA Summary Executive Director, tributed to improvements in human health and Health and medical research has played an important Strategic Policy Group H wellbeing throughout the world, and Australia has role in improving the life of Australians since before Warwick P Anderson played its part. As a result of this research, Australians have the 20th century, with many Australian researchers PhD benefi ted by remaining healthier for longer through better contributing to important advances both locally and Chief Executive Officer internationally. treatments and improved health care, and from contribu- National Health and Medical tions to national wealth through the development of in- The establishment of the National Health and Medical Research Council, Research Council (NHMRC) to support research and Canberra, ACT. novative industries. Despite the signifi cant role of research to work to achieve the benefi ts of research for the timothy.dyke@ in Australia, there have been few specifi c compilations on community was signifi cant. nhmrc.gov.au the Australian history of health and medical research. This The NHMRC has also provided guidance in research and article is a brief overview of Australian health and medical health ethics. doi: 10.5694/mja14.00347 research, with the role of the National Health and Medical Australian research has broadened to include basic Research Council (NHMRC) as a main focus. biomedical science, clinical medicine and science, public health and health services. The early years In October 2002, the NHMRC adopted Indigenous health research as a strategic priority.
    [Show full text]
  • The John Curtin School of Medical Research Annual Review 2012
    THE JOHN CURTIN SCHOOL OF MEDICAL RESEARCH ANNUAL REVIEW 2012 ANU College of Medicine, Biology & Environment CONTENTS Annual Review 2012 From the Director 3 The John Curtin School of Medical Organisation Chart 4 Research Committees 5 COMMUNITY 7 Official Opening of Stage 3 8 Launch of The John Curtin Medical Research Foundation 9 Professor Gordon Ada 10 Open Day 11 Community Activities 12 RESEARCH IN REVIEW 2012 15 Eccles Institute of Neuroscience 16 Department of Genome Biology 29 Department of Immunology 36 Department of Pathogens and Immunity 45 Department of Molecular Bioscience 47 Department of Translational Medicine 56 Australian Phenomics Facility 60 Biomolecular Resource Facility/Genome Discovery Unit 61 STAFF AND STUDENT ACHIEVEMENTS 63 VISITORS AND COLLABORATIONS 69 STAFF AND STUDENTS 85 Department of Genome Biology 86 Department of Immunology 87 Eccles Institute of Neuroscience 88 Department of Pathogens and Immunity 90 Department of Molecular Bioscience 90 Department of Translational Medicine 92 APF and Animal Services 92 School Services 94 School Administration 95 Students 96 PUBLICATIONS, PRESENTATIONS AND COMMUNITY OUTREACH 99 SUPPORT 129 Grants 130 Financial Overview 134 Donors 135 Sponsors 136 Annual Review 2012 1 2 The John Curtin School of Medical Research FROM THE DIRECTOR Zinkernagel. He will be sadly missed by his many friends and colleagues at the School, who have established the annual Gordon Ada New Investigator Award in his memory. In 2012, we finally completed the long and very necessary redevelopment project that resulted in the new John Curtin School of Medical Research building on the ANU campus. All our staff and students are once again under one roof, carrying out their research in state of the art laboratories and facilities.
    [Show full text]
  • JABBED PRESS KIT V15 (With Photos)
    Press Kit 1 x 90 Minute Science Documentary Writer, Director, Producer: Sonya Pemberton Executive Producers: Michael Cordell, Nick Murray & Sonya Pemberton Press Kit 1 x 90 Minute Science Documentary Writer, Director, Producer: Sonya Pemberton Executive Producers: Michael Cordell, Nick Murray & Sonya Pemberton Website: http://www.sbs.com.au/shows/jabbed Facebook: https://www.facebook.com/jabbedtv Twitter: #JabbedSBS Twitter account: @JabbedTV CONTENTS Synopsis I. one line II. one paragraph III. one page Media release Publicity Quotes The Families The Experts Key crew Director’s statement Production information Contacts ©2013 Genepool Productions Pty Ltd ABN 17153091019 www.genepoolproductions.com ©2013 Genepool Productions Pty Ltd Jabbed Love, fear and vaccines. PRESS KIT 1 SYNOPSIS: one line Jabbed Love, fear and vaccines. To vaccinate, or not? What would you do to protect the ones you love? SYNOPSIS: one paragraph Jabbed Love, fear and vaccines. Diseases that were largely eradicated forty years ago are returning. Across the world children are getting sick and dying from preventable conditions because nervous parents are skipping their children’s shots. And it’s not just kids: adults, too, are being hard hit. Yet the stories of vaccine reactions are frightening, with rare cases of people being damaged, even killed, by vaccines. How do we decide whether to vaccinate or not, and what are the real risks? Jabbed, made by 2012 Emmy Award-winning Australian documentary filmmaker Sonya Pemberton, travels the globe to look at the real science behind vaccinations, tracks real epidemics, and investigates the real cost of opting out. Talking with vaccine-makers, alternative healers, psychologists, anthropologists, and parents, the film posing the potent question: what would you do to protect the ones you love? Two years in the making Jabbed will confound your expectations, whatever your position on the most important and divisive public health question of the decade.
    [Show full text]
  • AMREP Research Report 2009
    The Alfred Medical Research and Education Precinct Research Report 2009 Alfred Health Commercial Road, Melbourne, Victoria 3004, Australia Telephone + 61 3 9076 2000 Facsimile + 61 3 9076 2222 2009 www.alfred.org.au The Alfred Medical Research & Education Precinct The Alfred Medical Research and Education Precinct © Alfred Health 2010 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part of this publication may be reproduced by any process without prior written permission from Alfred Health. Production team: Liana Friedman, Heather Gallichio, Cherry Yu, Eve Kovesdy Enquiries should be directed to the Research Office, [email protected] Design: abCreative Productions ISSN 1445-8853 Printing: Print Media Group contEnts AMREP in 2009/2010 2 AMREP’s Research Performance 4 AMREP Research Facilities 5 About AMREP Ian Potter Library 8 AMREP − Alfred Medical Research and Education Precinct − was established in 2002 Human Research Ethics Committee 9 as a partnership between Alfred Health, Monash University, Baker IDI Heart and Diabetes Animal Ethics Committee 11 Institute and the Macfarlane Burnet Institute for Medical Research and Public Health Translating Research into Clinical Practice 12 (Burnet Institute). La Trobe University and Deakin University joined the partnership in Allergy, Immunology and Respiratory Medicine 14 2005. AMREP is located on the campus of the Alfred Hospital, Melbourne and is one Anaesthesia and Perioperative Medicine 16 of Australia’s leading centres for medical research.
    [Show full text]
  • Scientists' Houses in Canberra 1950–1970
    EXPERIMENTS IN MODERN LIVING SCIENTISTS’ HOUSES IN CANBERRA 1950–1970 EXPERIMENTS IN MODERN LIVING SCIENTISTS’ HOUSES IN CANBERRA 1950–1970 MILTON CAMERON Published by ANU E Press The Australian National University Canberra ACT 0200, Australia Email: [email protected] This title is also available online at http://epress.anu.edu.au National Library of Australia Cataloguing-in-Publication entry Author: Cameron, Milton. Title: Experiments in modern living : scientists’ houses in Canberra, 1950 - 1970 / Milton Cameron. ISBN: 9781921862694 (pbk.) 9781921862700 (ebook) Notes: Includes bibliographical references and index. Subjects: Scientists--Homes and haunts--Australian Capital Territority--Canberra. Architecture, Modern Architecture--Australian Capital Territority--Canberra. Canberra (A.C.T.)--Buildings, structures, etc Dewey Number: 720.99471 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying or otherwise, without the prior permission of the publisher. Cover design by Sarah Evans. Front cover photograph of Fenner House by Ben Wrigley, 2012. Printed by Griffin Press This edition © 2012 ANU E Press; revised August 2012 Contents Acknowledgments . vii Illustrations . xi Abbreviations . xv Introduction: Domestic Voyeurism . 1 1. Age of the Masters: Establishing a scientific and intellectual community in Canberra, 1946–1968 . 7 2 . Paradigm Shift: Boyd and the Fenner House . 43 3 . Promoting the New Paradigm: Seidler and the Zwar House . 77 4 . Form Follows Formula: Grounds, Boyd and the Philip House . 101 5 . Where Science Meets Art: Bischoff and the Gascoigne House . 131 6 . The Origins of Form: Grounds, Bischoff and the Frankel House . 161 Afterword: Before and After Science .
    [Show full text]
  • The Bursa of Fabricius Award 12 ASI Councillors' News 13 Caption Competition 16 ASI Inc
    NEWSLETTER Australasian Society for Immunology Incorporated PP 341403100035 ISSN 1442-8725 March 2004 How to win a Nobel Prize in Physiology or Medicine Gordon Ada, John Curtin School of Medical Research When one thinks of winners of Nobel Prizes November to celebrate his contributions and at the Institute for 19 years when Frank came in these disciplines, there is a tendency to achievements. Peter and Rolf were present as to visit me in 1967. He told me he had visualize mature scientists who after many well as many of his past students (from 1972 relinquished the Headship of the Department years of laboratory work have accumulated to 2003) and others who worked in the of Microbiology to become the Director of lots of evidence to prove a particular concept Department, mainly in the 1970s. The the John Curtin School. He asked whether I or theory. This certainly happens, but there contributions, especially by past students, would let my name go forward as a candidate are many other situations. For example, one were remarkable for the variety of topics to succeed him as Head of the Microbiology recipient has provided the concept which a presented. Department? I decided yes, because under co-recipient has independently proven it to Frank Fenner, the Microbiology Department be correct. (e.g. Immunological tolerance, In the late 1960s I was happily working at the had reached international status and if I went Burnet and Medawar, 1960). In contrast, the Walter and Eliza Hall Institute (WEHI) with there, I could bring virology and immunology 1996 Prize resulted from a rather unusual Gus Nossal as a close colleague.
    [Show full text]
  • Reflections ...Gordon
    Reflections . Gordon Ada Life as a Biochemist Coming to Grips with Viruses Foreword It must be hard for recent graduates in many biological disciplines to appreciate what the frontiers of our knowledge were 50 years ago. The author majored in Biochemistry at the University of Sydney during the war and in 1948, joined the staff of the Walter and Eliza Hall Institute (WEHI) officially to help establish new biophysical techniques (moving boundary electrophoresis and ultracentrifugation), but spent most of the time doing research on virus-related topics. Macfarlane Burnet, a famous virologist, had become the Director of the Institute in 1942. This account describes some of the relevant biochemical findings made during the period 1948-60. Discovering the Secrets of the Influenza Virus The 1918-19 influenza pandemic killed at least 20 million people, more than the combined casualties of the two World Wars. Burnet, part way through his medical course at Melbourne University when it reached Australia, fortunately suffered only a mild infection, but the global and local effects remained a strong memory. On becoming Director of WEHI, and concerned that a similar pandemic might soon occur, he decided to make a determined effort to understand how the influenza virus infected and replicated inside cells and caused disease. Virtually all non-clinical scientists in the Institute were to become involved in this task. When I arrived in 1948, there were two other biochemists - Henry Holden, who earlier had achieved fame in the UK in elucidating the structure of haemoglobin, and Alfred Gottschalk (see Box 1), a carbohydrate specialist, who had escaped from Nazi Germany and joined the Institute in 1942.
    [Show full text]
  • What Price Australian Naway and an R Ami I R Fugees, 'Illegals' AUSTRALIAN BOOK REVIEW
    The Vatic -Edmund Campion on the Australia What price Australian naway and An r ami I r fugees, 'illegals' AUSTRALIAN BOOK REVIEW SEPTEMBER: Humphrey McQueen on Chris wattace~-Gra th e Chinese connecti on Dorothy Porter, Michael Hofmann, Fay Zwicky, Anthony Lawrence, Rolling Column by Mark Davis Anita Heiss, Merlinda Bobis, Tien Hoang Nguyen, Deb Westbury, Kerryn Goldsworthy on Thea Astley' s MTC Cronin, Dry lands Geoff Goodfellow and many mo re Marilyn Lake on Beryl Beaurepajre I melbourne Mari on Halli gan on Andrew Riemer's new memoir festival of Subscribers $55 for ten issues plus a free book Ph (03) 9429 6700 or Fax (03) 9429 2288 poetry september Art Monthly 1999 AUSTRALIA IN THE SEPTEMBER ISSUE chapel off Peter Hill interYiews Liz Ann Macgregor, new Director of the Museum of chapel Contemporary Art • prahran Daniel Thomas talks about being a curator 9522 3382 ArtRage - Mat Gallois on r;"t.,~;:;:;::::;-;;;;;::rn!l:;n~..r.w,,.,;::;;=rr-""""IIPII Off Chapel being an emerging artist in Sydney inHiative supported by Arts The Immigration Museum and the Victoria Millionth Migrant exhibition Out now _ S-1.9.'i, .fimn good boohlwps and ncii'Sagcnls. Or plu111c ()] 62-19 3986 jin· your mbsaiption Volume 9 Number 7 September 1999 A magazine of public affairs, the arts and theology CoNTENTS 4 COMMENT With Mark McKenna and 32 Francis Sullivan. AFTER THE BIG WAVE Photographic essay by Peter Davis. 'He loved to 7 speculate, CAPITAL LETTER 34 INDONESIAN WITNESS sometimes almost 8 Peter Mares interviews Ibu Sulami, dangerously, LETTERS activist, feminist and political survivor.
    [Show full text]
  • AMREP Research Report 2011
    The Alfred Medical Research and Education Precinct Research Report 2011 Research and Education Precinct Medical Research The Alfred 2 011 The Alfred Medical Research & Education Precinct Alfred Medical Research and Education Precinct Commercial Road, Melbourne, Victoria 3004, Australia www.amrep.org.au The Alfred Medical Research and Education Precinct The Alfred Medical Research and Education Precinct - AMREP - is a partnership between Alfred Health, Monash University, Baker IDI Heart and Diabetes Institute, Burnet Institute, La Trobe University and Deakin University. AMREP is located on the campus of The Alfred hospital, Melbourne. Alfred Medical Research & Education Precinct Commercial Road Melbourne, Victoria 3004 Australia www.amrep.org.au Acknowledgements Produced by Research Office, Alfred Health and Baker IDI Heart and Diabetes Institute Design by abCreative | abCreative.com CONTENTS AMREP Highlights 2011/2012 2 Andrew Way Research Output 4 Chief Executive, Human Ethics 6 Alfred Health Animal Ethics 7 Chair, AMREP Council Baker IDI Heart and Diabetes Institute 8 Nucleus Network 14 Burnet Institute 16 As I set out in my 2010/11 report, the benefits of Academic Health Monash School of Public Health and Preventive Medicine 24 Science Centres (AHSCs) continue to be widely discussed. Both Epidemiology and Preventive Medicine 25 State and Federal government departments are known to be Global Health 27 taking an increasing interest in their potential. AMREP, established Centre for Obesity Research and Education 28 in 2002, is Australia’s first and longest existing example of such Australasian Cochrane Centre 29 an endeavour, although when created no one at the time would Rheumatology (Musculoskeletal Epidemiology) 30 have thought – Academic Health Science Centre.
    [Show full text]
  • 2010-2011 Annual Report
    Annual Report 2010-2011 Mastery of disease through discovery | www.wehi.edu.au Contents 1 About the institute 3 Director’s and Chairman’s report 5 Discovery 8 Cancer and Haematology 10 Stem Cells and Cancer 12 Molecular Genetics of Cancer 14 Chemical Biology 16 Molecular Medicine 18 Structural Biology 20 Bioinformatics 22 Infection and Immunity 24 Immunology The Walter and Eliza Hall Institute 26 Autoimmunity and Transplantation of Medical Research 28 Cell Signalling and Cell Death 1G Royal Parade 30 Inflammation Parkville Victoria 3052 Australia Telephone: (+61 3) 9345 2555 32 Molecular Immunology Facsimile: (+61 3) 9347 0852 34 Publications WEHI Biotechnology Centre 36 Awards 4 Research Avenue 37 Translation La Trobe R&D Park Bundoora Victoria 3086 Australia Translating our research 38 Telephone: (+61 3) 9345 2200 40 Developing our research Facsimile: (+61 3) 9345 2211 42 Patents www.wehi.edu.au www.facebook.com/WEHIresearch 43 Education www.twitter.com/WEHI_research 46 2010-11 graduates ABN 12 004 251 423 47 Seminars Acknowledgements 48 Institute awards Produced by the institute’s Community Relations department 49 Engagement Managing editor: Penny Fannin Editor: Liz Williams 51 Strategic partners Writers: Liz Williams, Vanessa Solomon and Julie Tester 52 Scientific and medical community Design and production: Simon Taplin Photography: Czesia Markiewicz and Cameron Wells 54 Public engagement 57 Engagement with schools Cover image 58 Donor and bequestor engagement Art in Science finalist 2010 Vessel webs 59 Sustainability Dr Leigh Coultas, Cancer and Haematology division 60 The Board This image shows the delicate intricacy in the developing eye of a transient population of web-like blood vessels.
    [Show full text]
  • 25 Years of Making a Difference
    VITAMIN D AND MULTIPLE SCLEROSIS RESEARCH INGRID’S STORY: FROM TELETHON CHILD TO CHILD HEALTH RESEARCHER PLUS THE LATEST RESEARCH IN ABORIGINAL HEALTH, FASD, CYSTIC FIBROSIS AND MORE... Newsletter of the Telethon Kids Institute DISCOVER. PREVENT. CURE. 25 years of making a difference ETHAN DAVIES WITH HIS DAD SHANNON 2015 - Issue 1 telethonkids.org.au Celebrating years As our Founding Director Fiona Stanley puts it, the Telethon Kids Institute was formed on a “wing and a prayer” and while we offi cially opened our doors in June 1990, the unpredictable road to its inception began long before. It all started back in the late 1970s. Fiona was working with a small epidemiological research team at UWA, establishing the maternal and child health populati on data sets, including the birth defect and cerebral palsy registers, which would eventually provide such a great basis for the new insti tute. Not too far away at Princess Margaret Hospital, a small group of scienti sts including Pat Holt, Ursula Keys, Wayne Thomas and Geoff Stewart were working in immunology in the Telethon-funded Clinical Immunology Research Unit. INSTITUTE STAFF IN THE EARLY 1990’S “So Telethon really started funding this insti tute from 1970, even though we didn’t know we were going to have an insti tute at that ti me, by funding not only the “If we really wanted to understand why so many kids and immunology work at PMH but also some of our work at young people, not just in Western Australia but around UWA,” Fiona says. the world, had increasing rates of problems including asthma, obesity, suicide, developmental disorders and Then, in 1984 Lou Landau came to WA as Professor of diabetes, we had to understand the genes and cells, Paediatrics at UWA and he and Fiona began to talk.
    [Show full text]