RESEARCH ARTICLE Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis Zeyad D Nassar1,2†, Chui Yan Mah1,2†, Jonas Dehairs3, Ingrid JG Burvenich4, Swati Irani1,2, Margaret M Centenera1,2, Madison Helm1,2, Raj K Shrestha5, Max Moldovan2, Anthony S Don6, Jeff Holst7, Andrew M Scott4, Lisa G Horvath8, David J Lynn2,9, Luke A Selth1,5,9, Andrew J Hoy10, Johannes V Swinnen3, Lisa M Butler1,2* 1University of Adelaide Medical School and Freemasons Foundation Centre for Men’s Health, University of Adelaide, Adelaide, Australia; 2South Australian Health and Medical Research Institute, Adelaide, Australia; 3KU Leuven- University of Leuven, LKI- Leuven Cancer Institute, Department of Oncology, Laboratory of Lipid Metabolism and Cancer, Leuven, Belgium; 4Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Melbourne, Australia; 5Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, Adelaide, Australia; 6NHMRC Clinical Trials Centre, and Centenary Institute, The University of Sydney, Camperdown, Australia; 7Translational Cancer Metabolism Laboratory, School of Medical Sciences and Prince of Wales Clinical School, UNSW Sydney, Sydney, Australia; 8Garvan Institute of Medical Research, NSW 2010; University of Sydney, NSW 2006; and University of New South Wales, Darlinghurst, Australia; 9College of Medicine and Public Health, Flinders University, Bedford Park, Australia; 10Discipline of Physiology, School of *For correspondence: Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, The
[email protected] University of Sydney, Camperdown, Australia †These authors contributed equally to this work Competing interests: The b authors declare that no Abstract Fatty acid -oxidation (FAO) is the main bioenergetic pathway in human prostate competing interests exist.