Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous 845 Positive Airway Pressure: a Randomized Controlled Trial
1 2 Nasal Intermittent 3 4 Mandatory Ventilation 5 6 Versus Nasal Continuous Positive 7 Airway Pressure Before and After 8 9 Invasive Ventilatory Support 10 11 a, a 12 Osayame Ekhaguere, MBBS, MPH *, Shama Patel, MD , b 13 Haresh Kirpalani, BM, MSc Q2 Q3 14 15 16 KEYWORDS 17 Noninvasive respiratory support Continuous positive airway pressure 18 Noninvasive intermittent positive pressure ventilation Respiratory failure 19 Premature infants Intubation Heated humidified high-flow nasal cannula 20 21 22 KEY POINTS 23 Continuous positive airway pressure (CPAP), noninvasive intermittent positive pressure 24 ventilation (NIPPV), and heated humidified high-flow nasal cannula (HHFNC) are the main- 25 stays of primary and postextubation respiratory support in preterm infants. 26 The physiologic basis and practical application of CPAP and HHFNC are well delineated, 27 whereas those of NIPPV remain unsubstantiated and varied in the literature. 28 Available evidence suggests that NIPPV is superior to CPAP for primary and postextuba- 29 tion respiratory support in preterm infants. 30 Guidelines are needed on the practical application of NIPPV for preterm infants. 31 32 33 34 35 INTRODUCTION Q8 36 In current neonatal practice, a consensus now exists that avoidance or limitation of 37 invasive positive pressure ventilation in preterm infants when possible is of benefit.1 38 Clinical trials on noninvasive respiratory support for newborns began in the late 39 1960s.2,3 However, inadequate devices and interfaces and, serious complications 40 41 42 43 Disclosures: None. Q6 Q7 44 a Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Indiana University, Riley 45 Hospital for Children at Indiana University Health, 1030 West Michigan Street, C4600, Indian- b 46 apolis, IN 46202, USA; Department of Pediatrics, Division of Neonatology, The Children’s Q4 47 Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA * Corresponding author.
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