1. Ventilator Management
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Non-Invasive Ventilation Made Ridiculously Simple
NON-INVASIVE VENTILATION MADE RIDICULOUSLY SIMPLE Jennifer Newitt, MD 3rd year Pulmonary/Critical Care Fellow Mentor: Patrick Strollo Jr, MD Myth or Fact ?!? Myth or Fact ?!? Treatment for Obstructive Sleep Apnea ■ Lifestyle Modifications – Weight loss, increased fitness – Avoid alcohol, sleep deprivation, sedatives – Lateral position, head of bed elevation ■ Surgical – Upper airway reconstruction (UPP) or tracheostomy – Upper airway stimulation ■ Positive Airway Pressure via mask ■ Oral appliance therapy Treatment for Obstructive Sleep Apnea ■ Lifestyle Modifications – Weight loss, increased fitness – Avoid alcohol, sleep deprivation, sedatives – Lateral position, head of bed elevation ■ Surgical – Upper airway reconstruction (UPP) or trach – Upper airway stimulation ■Positive Positive Airway Pressure Airway via mask Pressure via mask ■ Oral appliance therapy 3 decades later…! Continuous Positive Airway Pressure (CPAP) ■ Continuous level of positive pressure provided to overcome airway obstruction ■ Patient must inhale and exhale over continuous pressure ■ Patient initiates all breaths ■ No additional pressure above level of CPAP is provided Continuous Positive Airway Pressure (CPAP) ■ Fixed CPAP – Fixed level of pressure between 4-20 cm H20 (ex: 10 cm H20) ■ Auto-CPAP – Variable pressure according to patient needs as detected by machine – If apnea, hypopnea, flow limitation, or snoring are detected, pressure is increased until events are eliminated – If no events are detected over set time period, pressure is decreased – Set pressure -
Airway Pressures and Volutrauma
Airway Pressures and Volutrauma Airway Pressures and Volutrauma: Is Measuring Tracheal Pressure Worth the Hassle? Monitoring airway pressures during mechanical ventilation is a standard of care.1 Sequential recording of airway pressures not only provides information regarding changes in pulmonary impedance but also allows safety parameters to be set. Safety parameters include high- and low-pressure alarms during positive pressure breaths and disconnect alarms. These standards are, of course, based on our experience with volume control ventilation in adults. During pressure control ventilation, monitoring airway pressures remains important, but volume monitoring and alarms are also required. Airway pressures and work of breathing are also important components of derived variables, including airway resistance, static compliance, dynamic compliance, and intrinsic positive end-expiratory pressure (auto-PEEP), measured at the bedside.2 The requisite pressures for these variables include peak inspiratory pressure, inspiratory plateau pressure, expiratory plateau pressure, and change in airway pressure within a breath. Plateau pressures should be measured at periods of zero flow during both volume control and pressure control ventilation. Change in airway pressure should be measured relative to change in volume delivery to the lung (pressure-volume loop) to elucidate work of breathing. See the related study on Page 1179. Evidence that mechanical ventilation can cause and exacerbate acute lung injury has been steadily mounting.3-5 While most of this evidence has originated from laboratory animal studies, recent clinical reports appear to support this concept.6,7 Traditionally, ventilator-induced lung injury brings to mind the clinical picture of tension pneumothorax. Barotrauma (from the root word baro, which means pressure) is typically associated with excessive airway pressures. -
Ventilation Patterns Influence Airway Secretion Movement Marcia S Volpe, Alexander B Adams MPH RRT FAARC, Marcelo B P Amato MD, and John J Marini MD
Original Contributions Ventilation Patterns Influence Airway Secretion Movement Marcia S Volpe, Alexander B Adams MPH RRT FAARC, Marcelo B P Amato MD, and John J Marini MD BACKGROUND: Retention of airway secretions is a common and serious problem in ventilated patients. Treating or avoiding secretion retention with mucus thinning, patient-positioning, airway suctioning, or chest or airway vibration or percussion may provide short-term benefit. METHODS: In a series of laboratory experiments with a test-lung system we examined the role of ventilator settings and lung-impedance on secretion retention and expulsion. Known quantities of a synthetic dye-stained mucus simulant with clinically relevant properties were injected into a transparent tube the diameter of an adult trachea and exposed to various mechanical-ventilation conditions. Mucus- simulant movement was measured with a photodensitometric technique and examined with image- analysis software. We tested 2 mucus-simulant viscosities and various peak flows, inspiratory/ expiratory flow ratios, intrinsic positive end-expiratory pressures, ventilation waveforms, and impedance values. RESULTS: Ventilator settings that produced flow bias had a major effect on mucus movement. Expiratory flow bias associated with intrinsic positive end-expiratory pressure generated by elevated minute ventilation moved mucus toward the airway opening, whereas in- trinsic positive end-expiratory pressure generated by increased airway resistance moved the mucus toward the lungs. Inter-lung transfer of mucus simulant occurred rapidly across the “carinal divider” between interconnected test lungs set to radically different compliances; the mucus moved out of the low-compliance lung and into the high-compliance lung. CONCLUSIONS: The move- ment of mucus simulant was influenced by the ventilation pattern and lung impedance. -
COVID-19 Pneumonia: Different Respiratory Treatment for Different Phenotypes? L
Intensive Care Medicine EDITORIAL Un-edited accepted proof COVID-19 pneumonia: different respiratory treatment for different phenotypes? L. Gattinoni1, D. Chiumello2, P. Caironi3, M. Busana1, F. Romitti1, L. Brazzi4, L. Camporota5 Affiliations: 1Department of Anesthesiology and Intensive Care, Medical University of GöttinGen 4Department of Anesthesia, Intensive Care and Emergency - 'Città della Salute e della Scienza’ Hospital - Turin 5Department of Adult Critical Care, Guy’s and St Thomas’ NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences - London Corresponding author: Luciano Gattinoni Department of Anesthesiology and Intensive Care, Medical University of Göttingen, Robert-Koch Straße 40, 37075, Göttingen, Germany Conflict of interests: The authors have no conflict of interest to disclose NOTE: This article is the pre-proof author’s accepted version. The final edited version will appear soon on the website of the journal Intensive Care Medicine with the following DOI number: DOI 10.1007/s00134-020-06033-2 1 Gattinoni L. et al. COVID-19 pneumonia: different respiratory treatment for different phenotypes? (2020) Intensive Care Medicine; DOI: 10.1007/s00134-020-06033-2 Intensive Care Medicine EDITORIAL Un-edited accepted proof The Surviving Sepsis CampaiGn panel (ahead of print, DOI: 10.1007/s00134-020-06022-5) recently recommended that “mechanically ventilated patients with COVID-19 should be managed similarly to other patients with acute respiratory failure in the ICU.” Yet, COVID-19 pneumonia [1], despite falling in most of the circumstances under the Berlin definition of ARDS [2], is a specific disease, whose distinctive features are severe hypoxemia often associated with near normal respiratory system compliance (more than 50% of the 150 patients measured by the authors and further confirmed by several colleagues in Northern Italy). -
Driving Pressure for Ventilation of Patients with Acute Respiratory
LWW 02/03/20 09:38 4 Color Fig(s): F1-2 Art: ALN-D-19-00974 CLINICAL FOCUS REVIEW Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M., Editor LWW Driving Pressure for Ventilation of Patients with Acute Anesthesiology Respiratory Distress Syndrome AQ1 Angela Meier, M.D., Ph.D., Rebecca E. Sell, M.D., Atul Malhotra, M.D. ALN ANET nvasive mechanical ventilation is a remarkable advance, Low Tidal Volumes Ibut the possibility of ventilator-induced lung injury exists, Low V mechanical ventilation is a well-established particularly if the ventilator settings are not optimized. The T anet method that limits ventilator-induced lung injury and best methods to avoid lung injury during mechanical ven- has been shown to improve mortality in clinical trials. An tilation, either during ventilation of healthy lungs in the original study by the ARDS Network published in 2000 operating room or during ventilation as support during aln compared a low versus high VT strategy and demonstrated critical illness, are topics of debate. In this review, we sum- a clear mortality benefit with the low V (6 ml/kg ideal marize the current evidence and review a relatively new T body weight) approach compared to a higher delivered VT ALN concept to prevent lung injury: targeting driving pressure (12 ml/kg ideal body weight).9 defined by plateau pressure minus positive end-expiratory ALN pressure (PEEP), see table 1) when setting and adjusting T1 mechanical ventilation. Positive End-Expiratory Pressure A promising single-center study looked at adjusting 0003-3022 Lung Injury PEEP settings based on measuring transpulmonary pres- sures.2 The authors used an esophageal balloon manometer Lung injury results from excess transpulmonary pressure to estimate pleural pressures in patients with ARDS. -
Respiratory Mechanics in Spontaneous and Assisted Ventilation Daniel C Grinnan1 and Jonathon Dean Truwit2
Critical Care October 2005 Vol 9 No 5 Grinnan and Truwit Review Clinical review: Respiratory mechanics in spontaneous and assisted ventilation Daniel C Grinnan1 and Jonathon Dean Truwit2 1Fellow, Department of Pulmonary and Critical Care, University of Virginia Health System, Virginia, USA 2E Cato Drash Professor of Medicine, Senior Associate Dean for Clinical Affairs, Chief, Department of Pulmonary and Critical Care, University of Virginia Health System, Virginia, USA Corresponding author: Daniel C Grinnan, [email protected] Published online: 18 April 2005 Critical Care 2005, 9:472-484 (DOI 10.1186/cc3516) This article is online at http://ccforum.com/content/9/5/472 © 2005 BioMed Central Ltd Abstract mined by the following equation: C = ∆V/∆P, where C is ∆ ∆ Pulmonary disease changes the physiology of the lungs, which compliance, V is change in volume, and P is change in manifests as changes in respiratory mechanics. Therefore, measure- pressure. The inverse of compliance is elastance (E ~ 1/C). ment of respiratory mechanics allows a clinician to monitor closely Airway pressure during inflation is influenced by volume, the course of pulmonary disease. Here we review the principles of thoracic (lung and chest wall) compliance, and thoracic respiratory mechanics and their clinical applications. These resistance to flow. Resistance to flow must be eliminated if principles include compliance, elastance, resistance, impedance, compliance is to be measured accurately. This is flow, and work of breathing. We discuss these principles in normal conditions and in disease states. As the severity of pulmonary accomplished by measuring pressure and volume during a disease increases, mechanical ventilation can become necessary. -
Sleep-Apnea-Protocol.Pdf
Evidence-based Practice Center Systematic Review Protocol Project Title: Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea in Medicare Eligible Patients I. Background Sleep apnea is a common disorder that affects people of all ages. It is characterized by periods of airflow cessation (apnea) or reduced airflow (hypopnea) during sleep. Sleep apnea may be caused by mechanical obstruction of the airways resulting in disturbed airflow patterns, by a central loss of respiratory drive, or a combination of the two (mixed). Obstructive sleep apnea- hypopnea syndrome, more commonly called obstructive sleep apnea (OSA), is the most common type of sleep apnea.1 Definition and severity of obstructive sleep apnea Sleep apnea is primarily diagnosed with sleep tests that measure sleep time (and often other sleep measures) and respiratory events. OSA is distinguished from central sleep apnea by the presence of respiratory effort during episodes of apnea and hypopnea (in contrast with central sleep apnea where respiratory effort is lacking). The severity of OSA is typically quantified by the sum of the number of apneas and hypopneas per hour of sleep, a quantity that has been termed the apnea-hypopnea index (AHI). AHI is often used as part of both diagnosis (and, thus, study inclusion criteria) and as a surrogate measure for health outcomes (also called an intermediate outcome) in studies. The American Academy of Sleep Medicine (AASM) publishes scoring manuals for AHI and other physiological events to characterize OSA. In the United States, AASM is the predominant accrediting institution for sleep laboratories. AASM first published its scoring manual in 1999 (known as the “Chicago” Criteria).2 They have amended their definitions of breathing events, sleep time, and how these are measured multiple times since their first set of criteria, with major revisions in 2007,3 and in 2012.4 Minor revisions have been made almost annually since (the current version is v2.6,5 released in 2020). -
The Basics of Ventilator Management Overview How We Breath
3/23/2019 The Basics of Ventilator Management What are we really trying to do here Peter Lutz, MD Pulmonary and Critical Care Medicine Pulmonary Associates, Mobile, Al Overview • Approach to the physiology of the lung and physiological goals of mechanical Ventilation • Different Modes of Mechanical Ventilation and when they are indicated • Ventilator complications • Ventilator Weaning • Some basic trouble shooting How we breath http://people.eku.edu/ritchisong/301notes6.htm 1 3/23/2019 How a Mechanical Ventilator works • The First Ventilator- the Iron Lung – Worked by creating negative atmospheric pressure around the lung, simulating the negative pressure of inspiration How a Mechanical Ventilator works • The Modern Ventilator – The invention of the demand oxygen valve for WWII pilots if the basis for the modern ventilator https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcRI5v-veZULMbt92bfDmUUW32SrC6ywX1vSzY1xr40aHMdsCVyg6g How a Mechanical Ventilator works • The Modern Ventilator – How it works Inspiratory Limb Flow Sensor Ventilator Pressure Sensor Expiratory Limb 2 3/23/2019 So what are the goals of Mechanical Ventilation • What are we trying to control – Oxygenation • Amount of oxygen we are getting into the blood – Ventilation • The movement of air into and out of the lungs, mainly effects the pH and level of CO 2 in the blood stream Lab Oxygenation Ventilation Pulse Ox Saturation >88-90% Arterial Blood Gas(ABG) Po 2(75-100 mmHg) pCO 2(40mmHg) pH(~7.4) Oxygenation How do we effect Oxygenation • Fraction of Inspired Oxygen (FIO 2) – Percentage of the gas mixture given to the patient that is Oxygen • Room air is 21% • On the vent ranges from 30-100% • So if the patient’s blood oxygen levels are low, we can just increase the amount of oxygen we give them 3 3/23/2019 How do we effect Oxygenation • Positive End Expiratory Pressure (PEEP) – positive pressure that will remains in the airways at the end of the respiratory cycle (end of exhalation) that is greater than the atmospheric pressure in mechanically ventilated patients. -
Neonatal Ventilation
Neonatal Ventilation Edward G. Shepherd History • Bourgeois, 1609: – “…give a small spoonfulof pure wine into the neonate’s mouth, …[to] help the infant to regain its spirits when being agitated by the labors, which sometimes make it so weak that it seems more dead than alive.” • Mauriceau, mid-1600’s: – “[The baby] should be rested on a warmed bed and brought near the fire, where the midwife having taken some wine into her mouth shall blow it into the infant’s mouth, which can be repeated several times if necessary … She should warm all the parts of the body to recall the blood and the spirits which retired during the weakness and endangered suffocation.” Neonatology 2008;94:144–149 History • Levret, 1766: – “There is one more means which sometimes works as by enchantment, it is to apply one’s mouth on that of the infant and to blow into it, taking care to pinch the tip of the nose simultaneously. This method is so effective that it is really rare that others are useful if it fails” Neonatology 2008;94:144–149 History • First ventilators: – Hunter, Chaussier, and Gorcy in the mid 1700’s • Bellows or gas attached to masks or tubes • 1800’s – Discovery of the breathing center – Determination of survival time in asphyxiated animals – First attempts at electrical resuscitation Neonatology 2008;94:144–149 History • By mid 1800’s ventilation fell out of favor – Fears of pnuemothorax, infection, and sudden death – Various positional techniques were developed • “Schultze swingings” • Arm extension and then chest compression – Stayed in practice -
Respiratory Support
Intensive Care Nursery House Staff Manual Respiratory Support ABBREVIATIONS FIO2 Fractional concentration of O2 in inspired gas PaO2 Partial pressure of arterial oxygen PAO2 Partial pressure of alveolar oxygen PaCO2 Partial pressure of arterial carbon dioxide PACO2 Partial pressure of alveolar carbon dioxide tcPCO2 Transcutaneous PCO2 PBAR Barometric pressure PH2O Partial pressure of water RQ Respiratory quotient (CO2 production/oxygen consumption) SaO2 Arterial blood hemoglobin oxygen saturation SpO2 Arterial oxygen saturation measured by pulse oximetry PIP Peak inspiratory pressure PEEP Positive end-expiratory pressure CPAP Continuous positive airway pressure PAW Mean airway pressure FRC Functional residual capacity Ti Inspiratory time Te Expiratory time IMV Intermittent mandatory ventilation SIMV Synchronized intermittent mandatory ventilation HFV High frequency ventilation OXYGEN (Oxygen is a drug!): A. Most infants require only enough O2 to maintain SpO2 between 87% to 92%, usually achieved with PaO2 of 40 to 60 mmHg, if pH is normal. Patients with pulmonary hypertension may require a much higher PaO2. B. With tracheal suctioning, it may be necessary to raise the inspired O2 temporarily. This should not be ordered routinely but only when the infant needs it. These orders are good for only 24h. OXYGEN DELIVERY and MEASUREMENT: A. Oxygen blenders allow O2 concentration to be adjusted between 21% and 100%. B. Head Hoods permit non-intubated infants to breathe high concentrations of humidified oxygen. Without a silencer they can be very noisy. C. Nasal Cannulae allow non-intubated infants to breathe high O2 concentrations and to be less encumbered than with a head hood. O2 flows of 0.25-0.5 L/min are usually sufficient to meet oxygen needs. -
Respiratory Therapy Pocket Reference
Pulmonary Physiology Volume Control Pressure Control Pressure Support Respiratory Therapy “AC” Assist Control; AC-VC, ~CMV (controlled mandatory Measure of static lung compliance. If in AC-VC, perform a.k.a. a.k.a. AC-PC; Assist Control Pressure Control; ~CMV-PC a.k.a PS (~BiPAP). Spontaneous: Pressure-present inspiratory pause (when there is no flow, there is no effect ventilation = all modes with RR and fixed Ti) PPlateau of Resistance; Pplat@Palv); or set Pause Time ~0.5s; RR, Pinsp, PEEP, FiO2, Flow Trigger, rise time, I:E (set Pocket Reference RR, Vt, PEEP, FiO2, Flow Trigger, Flow pattern, I:E (either Settings Pinsp, PEEP, FiO2, Flow Trigger, Rise time Target: < 30, Optimal: ~ 25 Settings directly or by inspiratory time Ti) Settings directly or via peak flow, Ti settings) Decreasing Ramp (potentially more physiologic) PIP: Total inspiratory work by vent; Reflects resistance & - Decreasing Ramp (potentially more physiologic) Card design by Respiratory care providers from: Square wave/constant vs Decreasing Ramp (potentially Flow Determined by: 1) PS level, 2) R, Rise Time ( rise time ® PPeak inspiratory compliance; Normal ~20 cmH20 (@8cc/kg and adult ETT); - Peak Flow determined by 1) Pinsp level, 2) R, 3)Ti (shorter Flow more physiologic) ¯ peak flow and 3.) pt effort Resp failure 30-40 (low VT use); Concern if >40. Flow = more flow), 4) pressure rise time (¯ Rise Time ® Peak v 0.9 Flow), 5) pt effort ( effort ® peak flow) Pplat-PEEP: tidal stress (lung injury & mortality risk). Target Determined by set RR, Vt, & Flow Pattern (i.e. for any set I:E Determined by patient effort & flow termination (“Esens” – PDriving peak flow, Square (¯ Ti) & Ramp ( Ti); Normal Ti: 1-1.5s; see below “Breath Termination”) < 15 cmH2O. -
ASV Quick Guide
ASV Quick Guide Hamilton Medical | ASV 1 ! Warning This Quick Guide is based on evaluations by clinicians within and outside Hamilton Medical and is intended to serve as an example. This Quick Guide does not replace either the official operator’s manual of your ventilator or the clinical judgment of a physician. This Quick Guide should not - on its own - be used for clinical decision making. 2 Table of contents 1. Adaptive Support Ventilation (ASV) basics 4 2. Preparing for ventilation with ASV 6 3. Settings 8 4. ASV graph 12 5. Working principles of ASV 14 6. Monitoring ASV 16 7. Adjusting ASV 18 8. Weaning in ASV 20 Appendix 22 Lung-protective rules 22 Understanding the ASV safety box 24 Glossary 26 Hamilton Medical | ASV 3 1. Adaptive Support Ventilation (ASV) basics 1 ... 2 CO elimination ... 2 3 Oxygenation Conventional ventilation ASV 4 ASV focuses on simplification of mechanical ventilation. This means: 1 Eliminating separate modes for passive and active patients 2 Reducing controls relevant for CO2 elimination to just %MinVol 3 Adding direct access to controls relevant for oxygenation (PEEP/CPAP and Oxygen) ASV maintains an operator-preset minimum minute volume independent of the patient‘s activity. The breathing pattern (tidal volume, rate, and inspiratory time) is calculated, based on the assump- tion that the optimal breathing pattern results in: a The least work of breathing b The least amount of ventilator-applied inspiratory pressure A lung-protection strategy ensures ASV’s safety. ASV attempts to guide the patient using a favorable breathing pattern and avoids potentially detrimental patterns such as rapid shallow breathing, excessive dead space ventilation, intrinsic PEEP, barotrauma, and volutrauma.