1 Effect of Continuous Positive Airway Pressure versus Supplemental Oxygen on Sleep 2 Quality in Obstructive Sleep Apnea: A placebo-CPAP controlled study 3 4 5 José S. Loredo, MD,a Sonia Ancoli-Israel PhD,b Eui-Joong Kim, MD,c,b 6 Weon Jeong Lim, MD,d,b And Joel E. Dimsdale MDb 7 8 9 From the Department of Medicine,a and the Department of Psychiatry,b University of California, 10 San Diego, the Department of Psychiatry, Eulji University, Daejeon, Korea,c Department of 11 Psychiatry, Ewha Womans University, Seoul, Korea d 12 13 This work was performed at the University of California San Diego 14 15 This work was supported in part by NIH grants HL44915, AG08415, M01 RR00827, HL36005 16 and K23 HL04056 17 18 The authors did not receive any financial support from or were involved with organization(s) 19 with financial interest in the subject matter 20 21 Address correspondence and requests for reprints to Dr. José S. Loredo, UCSD Medical Center 22 Dept. of Medicine, 200 West Arbor Drive, San Diego, CA 92103-0804. 23 Phone: (619) 543-5593. Fax: (619) 543-7519. E-mail:
[email protected] 1 24 ABSTRACT 25 Study Objectives: We investigated the short term effectiveness of CPAP and O2 in improving 26 sleep quality in patients with OSA. 27 Design: Randomized, double blinded, placebo-CPAP controlled, parallel study. 28 Setting: General Clinical Research Center at a University Hospital 29 Patients: Seventy-six untreated OSA patients 30 Interventions: Patients were randomized to one of three treatments (CPAP, placebo-CPAP, 31 nocturnal O2 at 3 L/min) for 2-weeks.