Ventilation Modes in Intensive Care Karin Deden
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Airway Pressures and Volutrauma
Airway Pressures and Volutrauma Airway Pressures and Volutrauma: Is Measuring Tracheal Pressure Worth the Hassle? Monitoring airway pressures during mechanical ventilation is a standard of care.1 Sequential recording of airway pressures not only provides information regarding changes in pulmonary impedance but also allows safety parameters to be set. Safety parameters include high- and low-pressure alarms during positive pressure breaths and disconnect alarms. These standards are, of course, based on our experience with volume control ventilation in adults. During pressure control ventilation, monitoring airway pressures remains important, but volume monitoring and alarms are also required. Airway pressures and work of breathing are also important components of derived variables, including airway resistance, static compliance, dynamic compliance, and intrinsic positive end-expiratory pressure (auto-PEEP), measured at the bedside.2 The requisite pressures for these variables include peak inspiratory pressure, inspiratory plateau pressure, expiratory plateau pressure, and change in airway pressure within a breath. Plateau pressures should be measured at periods of zero flow during both volume control and pressure control ventilation. Change in airway pressure should be measured relative to change in volume delivery to the lung (pressure-volume loop) to elucidate work of breathing. See the related study on Page 1179. Evidence that mechanical ventilation can cause and exacerbate acute lung injury has been steadily mounting.3-5 While most of this evidence has originated from laboratory animal studies, recent clinical reports appear to support this concept.6,7 Traditionally, ventilator-induced lung injury brings to mind the clinical picture of tension pneumothorax. Barotrauma (from the root word baro, which means pressure) is typically associated with excessive airway pressures. -
Advanced Modes of Ventilation: Concerns for the OR
Scott, Benjamin K., MD Advanced Modes of Ventilation: Concerns for the OR WHAT I AM NOT GOING TO COVER ADVANCED MODES OF “Adaptive” Advanced Modes that focus on synchrony VENTILATION: ✪ Proportional assist CONCERNS FOR THE OR ✪ Adaptive Support ✪ Neurally Adjusted Ventilatory Assist BENJAMIN K. SCOTT, MD DEPARTMENT OF ANESTHESIOLOGY UNIVERSITY OF COLORADO SCHOOL OF MEDICINE Why? ✪ Evidence of benefit is lacking ✪ Generally interchangeable with standard intraop modes DISCLOSURES PATHOPHYSIOLOGY OF THE SICK LUNG 1. ARDS Ashbaugh and Petty: 1967 case series of 12 ICU patients ✪ Tachypnea and hypoxemia NONE ✪ Opacification on CXR ✪ Poor lung compliance ✪ Diversity of primary insult Ashbaugh DG, Bigelow DB, Petty TL et al. Acute Respiratory Distress in Adults. Lancet. 1967 LEARNING OBJECTIVES PATHOPHYSIOLOGY OF THE SICK LUNG ARDS: The Berlin Definition (c. 2011) 1. Review the pathophysiology of the diseased or injured lung 2. Understand recent strategies in mechanical ventilation, ARDS is an acute diffuse, inflammatory lung injury, leading to particularly focusing on “low‐stretch” and “open‐lung” increased pulmonary vascular permeability, increased lung weight, techniques. and loss of aerated lung tissue...[With] hypoxemia and bilateral radiographic opacities, associated with increased venous 3. Discuss strategies for OR management of patients on admixture, increased physiological dead space and decreased “advanced” vent modes lung compliance. 4. Apply these concepts to routine OR vent management The ARDS Definition Task Force*. Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA. 2012;307(23):2526-2533 Scott, Benjamin K., MD Advanced Modes of Ventilation: Concerns for the OR PATHOPHYSIOLOGY OF THE SICK LUNG VENTILATING THE NON-COMPLIANT LUNG ARDS: The Berlin Definition (c. -
Noninvasive Positive Pressure Ventilation in the Home
Technology Assessment Program Noninvasive Positive Pressure Ventilation in the Home Final Technology Assessment Project ID: PULT0717 2/4/2020 Technology Assessment Program Project ID: PULT0717 Noninvasive Positive Pressure Ventilation in the Home (with addendum) Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No: HHSA290201500013I_HHSA29032004T Prepared by: Mayo Clinic Evidence-based Practice Center Rochester, MN Investigators: Michael Wilson, M.D. Zhen Wang, Ph.D. Claudia C. Dobler, M.D., Ph.D Allison S. Morrow, B.A. Bradley Beuschel, B.S.P.H. Mouaz Alsawas, M.D., M.Sc. Raed Benkhadra, M.D. Mohamed Seisa, M.D. Aniket Mittal, M.D. Manuel Sanchez, M.D. Lubna Daraz, Ph.D Steven Holets, R.R.T. M. Hassan Murad, M.D., M.P.H. Key Messages Purpose of review To evaluate home noninvasive positive pressure ventilation (NIPPV) in adults with chronic respiratory failure in terms of initiation, continuation, effectiveness, adverse events, equipment parameters and required respiratory services. Devices evaluated were home mechanical ventilators (HMV), bi-level positive airway pressure (BPAP) devices, and continuous positive airway pressure (CPAP) devices. Key messages • In patients with COPD, home NIPPV as delivered by a BPAP device (compared to no device) was associated with lower mortality, intubations, hospital admissions, but no change in quality of life (low to moderate SOE). NIPPV as delivered by a HMV device (compared individually with BPAP, CPAP, or no device) was associated with fewer hospital admissions (low SOE). In patients with thoracic restrictive diseases, HMV (compared to no device) was associated with lower mortality (low SOE). -
The Basics of Ventilator Management Overview How We Breath
3/23/2019 The Basics of Ventilator Management What are we really trying to do here Peter Lutz, MD Pulmonary and Critical Care Medicine Pulmonary Associates, Mobile, Al Overview • Approach to the physiology of the lung and physiological goals of mechanical Ventilation • Different Modes of Mechanical Ventilation and when they are indicated • Ventilator complications • Ventilator Weaning • Some basic trouble shooting How we breath http://people.eku.edu/ritchisong/301notes6.htm 1 3/23/2019 How a Mechanical Ventilator works • The First Ventilator- the Iron Lung – Worked by creating negative atmospheric pressure around the lung, simulating the negative pressure of inspiration How a Mechanical Ventilator works • The Modern Ventilator – The invention of the demand oxygen valve for WWII pilots if the basis for the modern ventilator https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcRI5v-veZULMbt92bfDmUUW32SrC6ywX1vSzY1xr40aHMdsCVyg6g How a Mechanical Ventilator works • The Modern Ventilator – How it works Inspiratory Limb Flow Sensor Ventilator Pressure Sensor Expiratory Limb 2 3/23/2019 So what are the goals of Mechanical Ventilation • What are we trying to control – Oxygenation • Amount of oxygen we are getting into the blood – Ventilation • The movement of air into and out of the lungs, mainly effects the pH and level of CO 2 in the blood stream Lab Oxygenation Ventilation Pulse Ox Saturation >88-90% Arterial Blood Gas(ABG) Po 2(75-100 mmHg) pCO 2(40mmHg) pH(~7.4) Oxygenation How do we effect Oxygenation • Fraction of Inspired Oxygen (FIO 2) – Percentage of the gas mixture given to the patient that is Oxygen • Room air is 21% • On the vent ranges from 30-100% • So if the patient’s blood oxygen levels are low, we can just increase the amount of oxygen we give them 3 3/23/2019 How do we effect Oxygenation • Positive End Expiratory Pressure (PEEP) – positive pressure that will remains in the airways at the end of the respiratory cycle (end of exhalation) that is greater than the atmospheric pressure in mechanically ventilated patients. -
Respiratory Support
Intensive Care Nursery House Staff Manual Respiratory Support ABBREVIATIONS FIO2 Fractional concentration of O2 in inspired gas PaO2 Partial pressure of arterial oxygen PAO2 Partial pressure of alveolar oxygen PaCO2 Partial pressure of arterial carbon dioxide PACO2 Partial pressure of alveolar carbon dioxide tcPCO2 Transcutaneous PCO2 PBAR Barometric pressure PH2O Partial pressure of water RQ Respiratory quotient (CO2 production/oxygen consumption) SaO2 Arterial blood hemoglobin oxygen saturation SpO2 Arterial oxygen saturation measured by pulse oximetry PIP Peak inspiratory pressure PEEP Positive end-expiratory pressure CPAP Continuous positive airway pressure PAW Mean airway pressure FRC Functional residual capacity Ti Inspiratory time Te Expiratory time IMV Intermittent mandatory ventilation SIMV Synchronized intermittent mandatory ventilation HFV High frequency ventilation OXYGEN (Oxygen is a drug!): A. Most infants require only enough O2 to maintain SpO2 between 87% to 92%, usually achieved with PaO2 of 40 to 60 mmHg, if pH is normal. Patients with pulmonary hypertension may require a much higher PaO2. B. With tracheal suctioning, it may be necessary to raise the inspired O2 temporarily. This should not be ordered routinely but only when the infant needs it. These orders are good for only 24h. OXYGEN DELIVERY and MEASUREMENT: A. Oxygen blenders allow O2 concentration to be adjusted between 21% and 100%. B. Head Hoods permit non-intubated infants to breathe high concentrations of humidified oxygen. Without a silencer they can be very noisy. C. Nasal Cannulae allow non-intubated infants to breathe high O2 concentrations and to be less encumbered than with a head hood. O2 flows of 0.25-0.5 L/min are usually sufficient to meet oxygen needs. -
Comparison Between Intermittent Mandatory Ventilation And
0021-7557/09/85-01/15 Jornal de Pediatria Copyright © 2009 by Sociedade Brasileira de Pediatria ARTIGO ORIGINAL Comparison between intermittent mandatory ventilation and synchronized intermittent mandatory ventilation with pressure support in children Comparação entre ventilação mandatória intermitente e ventilação mandatória intermitente sincronizada com pressão de suporte em crianças Marcos A. de Moraes1, Rossano C. Bonatto2, Mário F. Carpi2, Sandra M. Q. Ricchetti3, Carlos R. Padovani4, José R. Fioretto5 Resumo Abstract Objetivo: Comparar a ventilação mandatória intermitente (IMV) Objective: Tocompare intermittent mandatory ventilation (IMV) com a ventilação mandatória intermitente sincronizada com pressão with synchronized intermittent mandatory ventilation plus pressure de suporte (SIMV+PS) quanto à duração da ventilação mecânica, support (SIMV+PS) in terms of time on mechanical ventilation, desmame e tempo de internação na unidade de terapia intensiva duration of weaning and length of stay in a pediatric intensive care pediátrica (UTIP). unit (PICU). Métodos: Estudo clínico randomizado que incluiu crianças entre Methods: This was a randomized clinical trial that enrolled 28 dias e 4 anos de idade, admitidas na UTIP no período children aged 28 days to 4 years who were admitted to a PICU correspondente entre 10/2005 e 06/2007, que receberam ventilação between October of 2005 and June of 2007 and put on mechanical mecânica (VM) por mais de 48 horas. Os pacientes foram alocados, ventilation (MV) for more than 48 hours. These patients were por meio de sorteio, em dois grupos: grupo IMV (GIMV;n=35)e allocated to one of two groups by drawing lots: IMV group (IMVG; n grupo SIMV+PS (GSIMV; n = 35). -
Prevention of Ventilator Associated Complications
Prevention of Ventilator associated complications Authors: Dr Aparna Chandrasekaran* & Dr Ashok Deorari From: Department of Pediatrics , WHO CC AIIMS , New Delhi-110029 & * Neonatologist , Childs Trust Medical Research Foundation and Kanchi Kamakoti Childs Trust Hospital, Chennai -600034. Word count Text: 4890 (excluding tables and references) Figures: 1; Panels: 2 Key words: Ventilator associated complications, bronchopulmonary dysplasia Abbreviations: VAP- Ventilator associated pneumonia , BPD- Bronchopulmonary dysplasia, ELBW- Extremely low birth weight, VLBW- Very low birth weight, ROP- Retinopathy of prematurity, CPAP- Continuous positive airway pressure, I.M.- intramuscular, CI- Confidence intervals, PPROM- Preterm prelabour rupture of membranes, RCT- Randomised control trial, RR- Relative risk, PEEP- Peak end expiratory pressure Background: The last two decades have witnessed a dramatic reduction in neonatal mortality from 4.4 million newborn deaths annually in 1990 to 2.9 million deaths yearly in the year 2012, a reduction by 35%. In India, neonatal mortality has decreased by 42% during the same period. (1) With the increasing survival and therapeutic advances, the new paradigm is now on providing best quality of care and preventing complications related to therapy. Assisted ventilation dates back to 1879, when the Aerophone Pulmonaire, the world’s earliest ventilator was developed. This was essentially a simple tube connected to a rubber bulb. The tube was placed in the infant’s airway and the bulb was alternately compressed and released to produce inspiration and expiration. (2) With better understanding of pulmonary physiology and mechanics , lung protective strategies have evolved in the last two decades, with new resuscitation devices that limit pressure (T-piece resuscitator), non-invasive ventilation, microprocessors that allow synchronised breaths and regulate volume and high frequency oscillators/ jet ventilators. -
Mechanical Ventilation Page 1 of 5
UTMB RESPIRATORY CARE SERVICES Policy 7.3.53 PROCEDURE - Mechanical Ventilation Page 1 of 5 Mechanical Ventilation Effective: 10/26/95 Formulated: 11/78 Revised: 04/11/18 Mechanical Ventilation Purpose Mechanical Artificial Ventilation refers to any methods to deliver volumes of gas into a patient's lungs over an extended period of time to remove metabolically produced carbon dioxide. It is used to provide the pulmonary system with the mechanical power to maintain physiologic ventilation, to manipulate the ventilatory pattern and airway pressures for purposes of improving the efficiency of ventilation and/or oxygenation, and to decrease myocardial work by decreasing the work of breathing. Scope Outlines the procedure of instituting mechanical ventilation and monitoring. Accountability • Mechanical Ventilation may be instituted by a qualified licensed Respirator Care Practitioner (RCP). • To be qualified the practitioner must complete a competency based check off on the ventilator to be used. • The RCP will have an understanding of the age specific requirements of the patient. Physician's Initial orders for therapy must include a mode (i.e. mandatory Order Ventilation/Assist/Control, pressure control etc., a Rate, a Tidal Volume, and an Oxygen concentration and should include a desired level of Positive End Expiratory Pressure, and Pressure Support if applicable. Pressure modes will include inspiratory time and level of pressure control. In the absence of a complete follow up order reflecting new ventilator changes, the original ventilator settings will be maintained in compliance with last order until physician is contacted and the order is clarified. Indications Mechanical Ventilation is generally indicated in cases of acute alveolar hypoventilation due to any cause, acute respiratory failure due to any cause, and as a prophylactic post-op in certain patients. -
The Future of Mechanical Ventilation: Lessons from the Present and the Past Luciano Gattinoni1*, John J
Gattinoni et al. Critical Care (2017) 21:183 DOI 10.1186/s13054-017-1750-x REVIEW Open Access The future of mechanical ventilation: lessons from the present and the past Luciano Gattinoni1*, John J. Marini2, Francesca Collino1, Giorgia Maiolo1, Francesca Rapetti1, Tommaso Tonetti1, Francesco Vasques1 and Michael Quintel1 Abstract The adverse effects of mechanical ventilation in acute respiratory distress syndrome (ARDS) arise from two main causes: unphysiological increases of transpulmonary pressure and unphysiological increases/decreases of pleural pressure during positive or negative pressure ventilation. The transpulmonary pressure-related side effects primarily account for ventilator-induced lung injury (VILI) while the pleural pressure-related side effects primarily account for hemodynamic alterations. The changes of transpulmonary pressure and pleural pressure resulting from a given applied driving pressure depend on the relative elastances of the lung and chest wall. The term ‘volutrauma’ should refer to excessive strain, while ‘barotrauma’ should refer to excessive stress. Strains exceeding 1.5, corresponding to a stress above ~20 cmH2O in humans, are severely damaging in experimental animals. Apart from high tidal volumes and high transpulmonary pressures, the respiratory rate and inspiratory flow may also play roles in the genesis of VILI. We do not know which fraction of mortality is attributable to VILI with ventilation comparable to that reported in recent clinical practice surveys (tidal volume ~7.5 ml/kg, positive end-expiratory pressure (PEEP) ~8 cmH2O, rate ~20 bpm, associated mortality ~35%). Therefore, a more complete and individually personalized understanding of ARDS lung mechanics and its interaction with the ventilator is needed to improve future care. -
1. Ventilator Management
1. Ventilator Management Indications for Mechanical Ventilation Apnea Ventilatory insufficiency Increase in PaCo2 and decrease in ph Refractory hypoxemia Complications Associated with Mechanical Ventilation Hypotension Increased intrathoracic pressure decreases venous return to the heart Increased risk of ventilator associated pneumonia (VAP) Keep HOB at > 30 Maintain frequent, good oral care Problems with endotracheal tube Mucous plugging Tube my become dislodged Kinking or biting of tube Cuff rupture Pneumothorax Initial Ventilator Settings—parameters to be clarified Type of ventilation Mode of ventilation Tidal volume or peak inspiratory setting Respiratory rate FiO2 PEEP (Positive End Expiratory Pressure) Types of Ventilation Volume Cycled Ventilation(VCV) A pre-selected tidal volume is delivered at the pressure required. Tidal volume guaranteed. Peak inspiratory pressure will vary depending on airway resistance and lung compliance. Pressure Control Time-Cycled Ventilation (PCV) Operator selects inspiratory pressure and inspiratory time Breath is terminated when inspiratory time is reached Inspiratory pressure is guaranteed; tidal volume is dependant on airway resistance and lung compliance Pressure Support (PSV) Requires intact respiratory drive Operator selects inspiratory pressure Patient initiates breath, pressure quickly rises to set pressure and is maintained throughout the inspiratory phase Tidal volume determined by lung compliance and inspiratory effort Modes of Ventilation Assist/Control -
Mechanical Ventilation
Fundamentals of MMeecchhaanniiccaall VVeennttiillaattiioonn A short course on the theory and application of mechanical ventilators Robert L. Chatburn, BS, RRT-NPS, FAARC Director Respiratory Care Department University Hospitals of Cleveland Associate Professor Department of Pediatrics Case Western Reserve University Cleveland, Ohio Mandu Press Ltd. Cleveland Heights, Ohio Published by: Mandu Press Ltd. PO Box 18284 Cleveland Heights, OH 44118-0284 All rights reserved. This book, or any parts thereof, may not be used or reproduced by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the publisher, except for the inclusion of brief quotations in a review. First Edition Copyright 2003 by Robert L. Chatburn Library of Congress Control Number: 2003103281 ISBN, printed edition: 0-9729438-2-X ISBN, PDF edition: 0-9729438-3-8 First printing: 2003 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the author and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, express or implied, with respect to the contents of the publication. Table of Contents 1. INTRODUCTION TO VENTILATION..............................1 Self Assessment Questions.......................................................... 4 Definitions................................................................................ -
Pressure Control Ventilation .Pdf
Crit Care Clin 23 (2007) 183–199 Pressure Control Ventilation Dane Nichols, MD*, Sai Haranath, MBBS Division of Pulmonary & Critical Care Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mailcode UHN-67, Portland, OR 97239, USA As mechanical ventilators become increasingly sophisticated, clinicians are faced with a variety of ventilatory modes that use volume, pressure, and time in combination to achieve the overall goal of assisted ventilation. Although much has been written about the advantages and disadvantages of these increasingly complex modalities, currently there is no convincing evi- dence of the superiority of one mode of ventilation over another. It is also important to bear in mind that individual patient characteristics must be considered when adopting a particular mode of ventilatory support. As em- phasized in the 1993 American College of Chest Physicians Consensus Con- ference on Mechanical Ventilation, ‘‘although the quantitative response of a given physiologic variable may be predictable, the qualitative response is highly variable and patient specific’’ [1]. Partly because of the inherent difficulties in working with pressure venti- lation, the Acute Respiratory Distress Syndrome (ARDS) Network chose to use a volume mode of support for their landmark low tidal volumetrial [2]. The preference for volume ventilation at ARDS Network centers was later demonstrated in a retrospective study of clinicians’ early approach to me- chanical ventilation in acute lung injury/ARDS. Pressure control was used in only 10% of the patient population before study entry. There was a mod- est tendency to use pressure control ventilation (PCV) in patients with more severe oxygenation defects (PaO2/FiO2, or P/F !200) and a greater toler- ance for higher airway pressures when using this mode.