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Table 6A. PAG Delta Correlation Gene Networks Network 2 Network 3

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Table 6A. PAG Delta Correlation Gene Networks Network 2 Network 3 Table 6A. PAG Delta Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions ANXA6, Ap1, B4GALT1, CALM3, Calmodulin, Caspase, CDH22, CNR1, DAPK1, DLEU2, E2f, EGF, F Actin, 1 FCGR2A, GAD1, H19, HBA2, Histone h3, Hsp70, Insulin, Lipid Metabolism, Small Jnk, NFkB, Ntrk1 dimer, PI3K, Pkc(s), Pld, PLIN, PRKCB1, Molecule Biochemistry, Skeletal Ras, RPA2, RUNX1, SHC1, TTK, TXN, UBE2C 44 19 and Muscular Disorders AKAP12, ASXL1, CCL27, CKS2 (includes EG:1164), CTCF, DAD1, DUSP5, EEF1G, ELK3, ETV1, HIPK1, 2 HIPK3, HOXB5, ITGB6, KIF23, KRT15, LDB1, NCAN, PCK2, PLIN, PPARG, PRC1, RACGAP1, retinoic acid, RNF111, SKIL, SMURF2, SOD3, TGFB1, Timp, TNF, TP53, Cancer, Cell Cycle, UBE2C, UBE2D3, VEGFA 17 9 Hematological Disease AKT3, amino acids, beta-estradiol, CBLC, CHGB, CKS1B, COL6A2, COL6A3, EIF4E, glutamic acid, GP5, hydrogen peroxide, IL4, IL6, LGR4, LSM2, LSM4, LSM5, LSM6, 3 LSM7, MTMR7, MX2, NPY1R, PIM2, PLG, PPP5C, Gene Expression, Cell Death, PRDX5, RLBP1, SGK3, SLC17A, SLC17A7, SV2B, SYT11, Nervous System Development Timp, TXNIP 17 9 and Function PAG Delta Corr Networks Network 1 Network 2 Network 3 Table 6B. PAG Saline Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions Akt, ARHGEF4, B4GALT1, Calpain, CASP3, E2f, H19, HMOX1, Hsp27, Hsp70, Insulin, Jnk, LDL, MAP2, Mapk, Cell Morphology, Nervous 1 MAPT, MCM6, NFkB, NFKB2, P38 MAPK, Pdgf, Pdgf Ab, System Development and PDGF BB, PI3K, Pkc(s), PP2A, PPP2R2C, PRDX2, PTN, Function, Cardiovascular Ras, RPS14, SERPINF1, Tgf beta, TMOD2, Vegf 31 15 Disease A130040M12RIK, ADARB1, ANXA4, ARL6IP1, ASPM, Caspase, CBR2, CDKN1A, CRISP3 (includes EG:10321), Cyclin A, EG633736, FLNA (includes EG:445353), FOS, FXYD1, GSDMDC1, GZMM, HBA2, HRAS, IFNG, 2 KCNMA1, KCNT1, LOC100043429, LXN, MYC, NAE1, OMG, PARP1, Pka, RPL9 (includes EG:29257), RPS18, Cell Cycle, Cancer, RT1-B, SLC11A1, TOR2A, TTK, YY2 (includes Connective Tissue EG:404281) 20 10 Development and Function ACHE, AGT, AP3B2, AP3D1, beta-estradiol, CNP, COLQ, CTNNB1, CTNND2, CTSF, EDIL3, FCGRT, FRK, GBP2, 3 GM2A, GRIP2, H19, KCNMA1, KLK2, KRT5, L-carnitine, Immunological Disease, LIMA1, MAFF, NRF1, PAK7, PDZD2, PPRC1, PTPRN, Skeletal and Muscular RPS13, RPS4X, RPSA, SERPINB9, TGTP, TNF, WWOX 15 8 Disorders, Gene Expression PAG Saline Corr Networks Network 2 Network 1 Network 3 Table 6C. PFC Delta Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions Ap1, CCNA2, CCNO, Creb, Cyclin A, DNAJA1, DOK1, DUSP9, EGR1, FSTL1, GOSR2, Histone h3, Jnk, MAP3K12, Mapk, MEIS1, Mek, NAPG, NFkB, NSF, P38 1 MAPK, PCNA, Pdgf, PDGF BB, Pka, Pkc(s), POLE, POLS, PPP1R9A, PRKACA, PTTG1, RPS6KA5 (includes Cancer, Hematological EG:9252), STAT5A, TRIB3, TXNIP 40 19 Disease, Cell Cycle AHCY, APIP, ATP2B2, beta-estradiol, CASP3, CCDC80, DBI, DDX3X, DLG4, DRD2, GARS, GPRASP1, HNRNPC, HNRNPU, IFIT3, KCNA1, KCNA2, KCNA4, LRCH4, 2 MLF1, NAE1, PEX5L, Pmca, POMC, PPP1R9B, PRKDC, RAB8B, retinoic acid, RPL23A, SNF1LK, SNRP70, TK1, Cell Death, Neurological TSPO, YWHAZ, ZFAND6 27 14 Disease, Organ Morphology 2610042L04RIK, ALAD, ASGR2, C12ORF5, CANX, CEBPA, CLDN4, DDIT4, DICER1, EFNA4, EPHA2, ERBB2, ERCC5, FCGRT, FLG, GABARAP, HLA-B, 3 IGF1R, KCNJ4, MYC, PCBP2, PHF17, PMP22, POLD1, POLE2, PRIM1, RPS21, SERPINI1, SHMT1, TP53, TP63, Cancer, Respiratory Disease, UBE2C, UBE2V2, UBQLN1, VHL 22 12 Cell Cycle PFC Delta Corr Networks Network 1 Network 2 Network 3 Table 6D. PFC Saline Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions Ap1, beta-estradiol, BLR1, CABIN1, CCDC80, CST3, CSTB, CTLA2A, CTSH, CTSL1, DNER, eIF2B, EIF2B4, EIF2B5, EIF2S2, ERN1 (includes EG:2081), GLO1, GLUL, 1 GSK3A, GSK3B, HPSE, IL4, IL6, LGALS2, MAF, NCK1 (includes EG:29696), NFATC3, NR3C1, NUPR1, Pka, Cancer, Tumor Morphology, Pkc(s), PSEN1, PSEN2, SLC6A1, SLC6A2 26 12 Cellular Development 2-mercaptoethanol, ABCB1B, ADRA1A, ADRA1B, ADRA1D, ALDH7A1, ATP2A2, B4GALT1, CCKAR, CCL20, CDC42EP1, CDKN2D, DCN, EDNRB, EGR1, F2, F10, FMO1, GDF15, Gq-coupled receptor, GTF2I, IL1R1, Cellular Growth and 2 IRS4, ITGB3BP, LHB, NFkB, PDGF BB, PDGFC, PGF, Proliferation, Cardiovascular PPP4C, PRRX1, RLN2, SOCS1, Thyroid hormone receptor, System Development and TRIM8 23 11 Function, Tissue Morphology ALOX5, ANGPT1, ANP32A, CDH2, CTP, DCN, DNAJB6, EIF4E, ELF3, ELK3, ENTPD4, ERBB2, ETS, FBN1, 3 FOSL1, GNAI1, GPX3, GTP, KRT8, LSM1, LSM2, LSM4, LSM5, LSM6, LSM7, MAP4, MYCN, NFYC, RFC3, RFC4, Cell Death, Cancer, RPL6, SNRPD3, TGFB1, TNC, WFS1 16 8 Organismal Survival PFC Sal Corr Networks Network 1 Network 2 Network 3 Table 6E. TL Delta Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions ADAM9, Akt, Ap1, APBA2, AR, Calcineurin protein(s), Calpain, CAPN3, Caspase, CEBPD, CENPA, Creb, DNER, EPS15, FRAP1, GTF2F1, HABP4, Insulin, ITGB1, KCNQ1, 1 LAMB1, MGST1, NFkB, P38 MAPK, PDGF BB, PI3K, Pka, Nervous System Development Pkc(s), PP2A, PPP3CB, PRKACA, RELA, STX3, TRIM27, and Function, Tissue YY1 44 21 Development, Cancer ARFIP1, C1QA, COL4A2, CTBP2, DDAH2, DEFA1 (includes EG:1667), EFEMP2, EHMT1, ELN, ERCC1, ERCC5, HCG 1787519, HINT1 (includes EG:3094), HSPB1, IPO9, JRK, KIF23, MGMT, MMP9, MRPL38, retinoic acid, Cardiovascular Disease, 2 RPS3, RPS7, RPS9, RPS28 (includes EG:54127), Organismal Injury and SERPING1, SMC3, STAG1, TEP1, TGFBI, THBS2, Abnormalities, Dermatological TNFAIP2, TP53, UBE2T, WIZ 26 14 Diseases and Conditions AFAP1L2, CD151, CKAP4, COL1A1, EGFR, EVL, F2, FUT8, G-protein gamma, GFER, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNG12, GNG13, MTSS1, Cell Signaling, Cellular 3 MYC, NRSN1, PCBP1 (includes EG:5093), PDC, PTPRA, Assembly and Organization, PTPRD, PTPRE, PTPRS (includes EG:5802), RPL35, SAG, Cell-To-Cell Signaling and SEMA6A, SERPINH1, SH3BGRL, SRC, TPPP 21 12 Interaction TL Delta Corr Networks Network 1 Network 2 Network 3 Table 6F. TL Saline Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions Akt, ANGPT2, Ap1, AR, BIRC5, Caspase, CDC20, CEBPD, Creb, Cyclin E, EMI1, GLO1, HBA2, HBXIP, HEY1, Jnk, 1 KCNC1, LITAF, Mapk, MAPK15, MIF, NFkB, Pdgf, PI3K, PLAUR, PTTG1, RUVBL2, RXRA, SLC12A6, SNURF, Cancer, Cell Cycle, Tumor SOCS4, STAT5A, TCF19, TMOD2, WASF3 45 20 Morphology androstenediol, AREG, ARFGAP3, beta-estradiol, CBR2, CGB, CYP24A1, EGF, ENTPD4, EPB41L1, ERH, FUS, Cellular Development, GPD2, GPSM2, GSK3A, GTP, HAS2, HRAS, ID4, IER3, Cellular Growth and 2 IL7R, NGFB, NOTCH3, NUMA1, P110, PTGER2, PTGS1, Proliferation, Reproductive PTTG1, RANBP9, RASD2, RELA, SMC3, SNIP, SRP54, System Development and Voltage Gated Calcium Channel 23 12 Function ABCB11, ACO2, Aconitase, ADAM9, ATP1A2, ATP1B2, AURKB, CABP1, CHI3L1, H3F3A, H3F3B, HBE1, Hd- neuronal intranuclear inclusions, Hd-perinuclear inclusions, 3 HIP1, Histone h3, HTT, IL1B, JUN, LTP, MYST2, NPY, PELP1, PRNP, RNF4, SERP1, SH3D19, SH3GL3, SLC10A2, SLC39A14, SMARCD1, SMARCD2, Cell Death, Neurological SMARCD3, SWI-SNF, TMEM158 21 11 Disease, Cell Signaling TL Sal Corr Networks Network 1 Network 2 Network 3 Table 6G. VS Delta Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions 2-amino-3-phosphonopropionic acid, Akt, ARF1, ARF5, ARFIP2, ASC2, DAP3, DEFA1 (includes EG:1667), EDF1, EGR1, FOS, GCH1, GDI1, HSPB8, hydroquinone, IDE, 1 Insulin, Jnk, MAGI1, NFkB, P38 MAPK, Pdgf, Pdgf Ab, Cell Death, Hematological PDGF BB, PDGFC, Pkc(s), PRKCG, PSCD2, PTPN6, Disease, Immunological RORC, SDCBP, SLC2A1, TCR, TGM1, TGM2 32 15 Disease ACTG1, Actin, APP, CAP1, CAP2, CAPRIN1, CCR6, CELSR2, chondroitin sulfate B, CHST11, DAP3, EIF6, EIF4E, ELAVL3, G3BP1, GTP, IL10, ILF3, ILF2 (includes EG:3608), KIF5A, KIF5C, KLC2, NAE1, PHACTR1, Cellular Development, 2 PSMA3, PTPRK, retinoic acid, S100A11 (includes Cellular Growth and EG:6282), SEPT3, TGFB1, TGFBI, TIA1, TUBB2C, Proliferation, Hair and Skin TUSC2, XRN2 29 14 Development and Function ABCB1B, C19ORF10, CDH11, CTSH, CUL7, CYFIP2, DDX17, DNAJA1, DNAJA2, ECM1, FBXW8, FSTL1, GAS1, GCLM, Hd-neuronal intranuclear inclusions, HSPA9, 3 HTT, hydrogen peroxide, IL13, LEP, LGALS3BP, MAPK1, MYC, NID1, PDE6G, PLXNB2, PON3, PRDX1, PTP4A2, Cellular Compromise, DNA SLC25A5, ST3GAL6, SYNGR3, TNF, TP53, YY2 (includes Replication, Recombination, EG:404281) 26 13 and Repair, Cell Death VS Delta Corr Networks Network 2 Network 1 Network 3 Table 6H. VS Saline Correlation Gene Networks Focus ID Molecules in Network Score Molecules Top Functions Akt, ALOX12, Ap1, Caspase, CDKN2D, CDT1, CRYAB, CSDE1, E2f, EGR1, GNB1, GRLF1, GSPT1, HABP4, HLA- C, JARID2, Jnk, NEDD4, NFkB, P38 MAPK, Pdgf, PDGF 1 BB, PI3K, Pkc(s), PRDX2, PRKCG, RANBP1, RBP1, Post-Translational RHOA, SDCBP, SEPT4, SERPINF1, TRAF7, UBE3A, Modification, Organ Ubiquitin 50 23 Development, Cell Death ACHE, AKT1, CAMKK1, CCND1, CCT3, CCT7, CDC42, CDH1, CDKN2D, CDX1, CK1, COLQ, CSNK1G1, CTNNB1, DUSP14, GLO1, GTPBP4, HNRNPL, INVS, 2 LMO7, MAFF, MCF2, MCF2L, MYO9B, Nectin, NRF1, Cellular Assembly and PISD, PTGDS, PVRL1, PVRL3, RRM1, TMED10, TNF, Organization, Cell Death, Cell UCP1, VHL 31 16 Cycle AHSG, ALPP, ARCN1, BET1L, COPA, COPB1, COPB2, COPE, COPG, COPZ1, CPD, CPT2, GOLGB1, LYPD1, Cellular Development, MYC, MYCBP2, MYCN, NEFL, NUCKS1, phosphate, Cellular Growth and 3 PRPH, RPL19, RPL13A, RPL7L1, RPLP2, RPS7, Proliferation, Respiratory ST6GAL1, STX5, TERT, TGFB1, TMED9, USO1, XBP1, System Development and ZHX2, ZNF217 19 11 Function VS Sal Corr Networks Network 1 Network 2 Network 3 .
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