Accepted Manuscript

The Role of Psychiatric Diagnoses for Outcome after Hip and Knee Arthroplasty

Silas Hinsch Gylvin, Christoffer Calov Jørgensen, Anders Fink-Jensen, Gunnar Hilmar Gislason, Henrik Kehlet

PII: S0883-5403(17)30580-6 DOI: 10.1016/j.arth.2017.06.051 Reference: YARTH 55977

To appear in: The Journal of Arthroplasty

Received Date: 10 February 2017 Revised Date: 27 June 2017 Accepted Date: 29 June 2017

Please cite this article as: Gylvin SH, Jørgensen CC, Fink-Jensen A, Gislason GH, Kehlet H, on behalf of the Lundbeck Foundation Centre for Fast-track Hip and knee replacement collaborative group, The Role of Psychiatric Diagnoses for Outcome after Hip and Knee Arthroplasty, The Journal of Arthroplasty (2017), doi: 10.1016/j.arth.2017.06.051.

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The Role of Psychiatric Diagnoses for Outcome after Hip and Knee Arthroplasty

Silas Hinsch Gylvin 1,2 , Christoffer Calov Jørgensen 1,2 , Anders Fink-Jensen 3, Gunnar Hilmar Gislason 4 1,2 Henrik Kehlet ; on behalf of the Lundbeck Foundation Centre for Fast-track Hip and knee replacement collaborative group*

1Section of Surgical Pathophysiology, Rigshospitalet, ; 2 Lundbeck Foundation Centre for Fast-track Hip and Knee Arthroplasty; 3Psychiatric Centre and Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark; 4 Department of Cardiology, and Gentofte University Hospital, 2900 Hellerup, Denmark; 5The Danish Heart Foundation, 1127 Copenhagen K, Copenhagen, Denmark.

Corresponding author:

Dr. Silas Hinsch Gylvin Section of Surgical Pathophysiology, 4074 Copenhagen University Hospital, Rigshospitalet Blegdamsvej 9 DK-2100 Copenhagen Denmark Phone: +45-51296805 Fax: +45-35456543 Email: [email protected] MANUSCRIPT

Running title: Influence of Psychiatric Disorder and psychopharmacological treatment on surgical outcome in THA and TKA

Word count: 2.366

Key words: Psychiatric disease, psychopharmacology, hip and knee arthroplasty, perioperative management

*Members of the Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group are the following: Frank Madsen , D.M.Sci., Department of Orthopedics, University Hospital, , Aarhus, Denmark; Torben B. Hansen , D.M.Sci., Department of Orthopedics, Regional Hospital Holstebro, Aarhus University, Aarhus, Denmark; Henrik Husted , D.M.Sci., Orthopedic Department, University Hospital, Copenhagen University, Copenhagen, Denmark; Mogens B. Laursen , Ph.D., Orthopedic Division, Hospital, Aalborg University, Aalborg, Denmark ; Lars T. Hansen , M.D., Orthopedic Department, Sydvestjysk Hospital /, Esbjerg, Denmark; Per Kjærsgaard-Andersen , M.D., Department of Orthopedics, Hospital, University of Southern Denmark, , Denmark; and Søren Solgaard , D.M.Sci., Department of Orthopedics, Gentofte UniversityACCEPTED Hospital, Hellerup, Denmark.