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Glosario De Histopatología Tumores Epiteliales De Las

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Glosario De Histopatología Tumores Epiteliales De Las GLOSARIO DE Samar y Avila HISTOPATOLOGIA Tumores epiteliales de las glándulas salivales 2º edición -2015- GLOSARIO DE HISTOPATOLOGIA Tumores epiteliales de las glándulas salivales María Elena Samar. Dra. en Medicina y Cirugía. Magister en Salud Materno-Infantil. Docente Universitaria en Odontología y en Medicina. Investigadora Categoría 1. Profesora de Histología y Embriología. Departamento de Biología Bucal. Facultad de Odontología. Universidad Nacional de Córdoba. Docente de la Cátedra Santiago Ramón y Cajal Universidad de Ciencias Médicas de La Habana. Cuba. Miembro del Comité de Expertos en Terminología histológica. Simposio Iberolatinoamericano de Terminología (SILAT). Asociación Panamericana de Anatomía. Miembro fundador de la Academia Panamericana de Anatomía. Vice-presidente del Capítulo Anatomía y Biología del Desarrollo. Asociación Argentina de Anatomía Clínica. Rodolfo Esteban Avila. Dr. en Medicina y Cirugía. Magister en Gerencia y Administración de Servicios de Salud. Magister en Bioética. Docente Universitario en Medicina. Investigador Categoría 1. Profesor de Biología Celular, Histología y Embriología. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Docente de la Cátedra Santiago Ramón y Cajal Universidad de Ciencias Médicas de La Habana. Cuba. Miembro del Comité de Expertos en Terminología embriológica. Simposio Iberolatinoamericano de Terminología. Asociación Panamericana de Anatomía. Miembro fundador de la Academia Panamericana de Anatomía. Presidente del Capítulo Anatomía y Biología del Desarrollo. Asociación Argentina de Anatomía Clínica. Glosario de histopatología: tumores epiteliales de las glándulas salivales / María Elena Samar... [et al.] ; dirigido por María Elena Samar; Rodolfo Esteban Avila. - 2a ed. edición especial. - Córdoba: María Elena Samar, 2015. CD-ROM, PDF ISBN 978-987-33-8825-5 1. Patología Bucal. I. Samar, María Elena II. Samar, María Elena, dir. III. Avila, Rodolfo Esteban, dir. CDD 611.018 2015. Samar ediciones. Córdoba. República Argentina Coautores Fonseca Ismael Corball Alberto Ferraris Ricardo Ferraris Luis García Pedro Olmedo Luis Augusto Juri Hugo Furnes Marta Fernández Javier Juri Gustavo PROLOGO Las neoplasias de glándulas salivales mayores y menores humanas constituyen un desafío para clínicos e histopatólogos. Son entidades nosológicas poco frecuentes y sus características histológicas, clínicas, epidemiológicas y evolutivas son muy complejas y variadas. En la literatura especializada se menciona que en las glándulas salivales se originan no menos de 30 tipos histológicos diferentes de tumores, con sus variedades y subtipos. Representan menos del 2% de todas las neoplasias humanas y alrededor del 3% de los tumores de cabeza y cuello. Dentro de los tumores benignos el más común es el adenoma pleomórfico, en tanto que el carcinoma mucoepidermoide es el tumor maligno más frecuente. Entre el 70 y 80% de las neoplasias asienta en parótida, siendo el paladar el sitio más común para glándulas salivales menores, reportándose en algunas investigaciones variaciones geográficas. El estadio tumoral, el subtipo histológico y el grado de malignidad son los factores más importantes para la sobrevida, según relatan Licitra et al, investigadores del proyecto START de la Escuela Europea de Oncología, instrumento basado en la evidencia (Licitra L, Grandi C, Prott FJ, Schrnagel JH, Bruzzi P, Molinari R 2003: Major and minor salivary glands tumors. Crit Rev Oncol Hematol 45: 215-225). Teniendo en cuenta estos aspectos hemos elaborado la 2º edición actualizada en contenidos y terminología histológica del glosario ilustrado de los tumores epiteliales de glándulas salivales, en soporte CD-ROM dirigido a orientar al estudiante de Medicina de grado y postgrado, a los residentes de Anatomía Patológica, a los jóvenes que se inician en la investigación de esta área del conocimiento y a los médicos generalistas. El objetivo principal de nuestro trabajo es facilitar el acceso al vocabulario específico de esta compleja temática. Este material se desarrolló en el marco de nuestro Proyecto de Investigación sobre Tumores Epiteliales Benignos y Malignos de Glándulas Salivales Mayores y Menores Humanas, proyecto iniciado en el año 2006 y subsidiado por la Secretaría de Ciencia y Tecnología de la Universidad Nacional de Córdoba, Argentina, y que nos brinda la posibilidad concreta de trabajar con un equipo interdisciplinario integrado por médicos histólogos, embriólogos, patólogos, oncólogos clínicos, especialistas de cabeza y cuello y odontólogos. Todo lo cual enriquece la investigación integrando los núcleos de conocimiento de las distintas disciplinas. (LOW-GRADE PAPILLARY ADENOCARCINOMA OF THE PALATE): ejemplo de cistoadenocarcinoma. A ADENOCARCINOMA ACINO (ACINUS; PL. ACINI): CRIBIFORME DE LENGUA adenómero. Unidad secretora de (CRIBIFORM las glándulas salivales, ADENOCARCINOMA OF constituida por células TONGUE): variante del piramidales que delimitan una adenocarcinoma polimorfo de luz central pequeña hacia donde bajo grado, con crecimiento vuelcan sus secreciones. cribiforme prominente. ADENOCARCINOMA DE CELULAS ACINARES (ACINIC CELLS ADENOCARCINOMA): tumor epitelial maligno, donde se observan células neoplásicas con diferenciación predominante tipo serocitos, semejantes a los serocitos normales. Según AFIP, este carcinoma es el segundo más común dentro de las neoplasias malignas de glándulas salivales. ACTINA (ACTIN): proteína Se localiza en la glándula globular que al polimerizarse parótida en el 80% de los casos. forma los microfilamentos del Sus patrones de crecimiento citoesqueleto, abundantes en el pueden ser de tipo sólido o córtex celular y relacionados con lobular, microquístico, papilar, el mantenimiento y los cambios quístico o folicular. de forma de las células, así como con las uniones intermedias. Los microfilamentos de actina constituyen los miofilamentos finos del aparato contráctil de los miocitos y son muy abundantes en los mioepiteliocitos y miofibroblastos. ADENOCARCINOMA PAPILAR DE BAJO GRADO DE PALADAR 6 Adenocarcinoma de células coalescencia de las células acinares. Proyección papilar. vacuoladas. Tricrómico de Dane. ADENOCARCINOMA DE CELULAS ACINARES DESDIFERENCIADO (DEDIFFERENTIATED ACINIC CELL ADENOCARCINOMA): pequeño número de tumores con características de adenocarcinoma de células acinares, que presenta áreas de carcinoma indiferenciado. Adenocarcinoma de células ADENOCARCINOMA DE acinares. Patrón CELULAS ACINARES PATRON microquístico. H/E. FOLICULAR (FOLLICULAR PATTERN ACINIC CELL ADENOCARCINOMA DE ADENOCARCINOMA): CELULAS ACINARES PATRON adenocarcinoma de células QUÍSTICO PAPILAR (CYSTIC acinares que desarrolla un PAPILLARY PATTERN ACINIC patrón semejante a los folículos CELL ADENOCARCINOMA): tiroideos, con múltiples luces adenocarcinoma de células quísticas revestidas por acinares que desarrolla un epiteliocitos y llenas de material patrón caracterizado por la eosinofílico tipo proteináceo. presencia de luces prominentes tipo quistes, parcialmente ADENOCARCINOMA DE ocupadas con proliferaciones CELULAS ACINARES PATRON epiteliales papilares. Los MICROQUISTICO espacios quísticos suelen verse (MICROCYSTIC PATTERN durante la observación ACINIC CELL macroscópica. ADENOCARCINOMA): adenocarcinoma de células ADENOCARCINOMA DE acinares que desarrolla un CELULAS ACINARES PATRON patrón que se caracteriza por la SOLIDO (SOLID GROWTH presencia de espacios PATTERN ACINIC CELL numerosos y pequeños dentro ADENOCARCINOMA): tumor de capas de células neoplásicas. que presenta un patrón de Dichos espacios serían la crecimiento sólido que se consecuencia de la ruptura o caracteriza por láminas de 7 células neoplásicas sin la variables de epiteliocitos presencia de luces o con luces basaloides separadas por escasas. bandas gruesas o delgadas de estroma colágeno. ADENOCARCINOMA DE CELULAS BASALES (BASAL CELL ADENOCARCINOMA): contraparte maligna del adenoma de células basales, que se diferencia de éste por su crecimiento infiltrativo, invasión vascular y perineural más agresiva y una incidencia baja de metástasis. En algunos trabajos se lo denomina como: carcinoma salival basaloide, Adenocarcinoma de células carcinoma ex adenoma basales tipo sólido. H/E. monomórfico, adenoma de células basales maligno y ADENOCARCINOMA DE carcinoma de células basales. CELULAS BASALES TIPO TRABECULAR (BASAL CELL ADENOCARCINOMA DE ADENOCARCINOMA CELULAS BASALES PATRON TRABECULAR PATTERN): MEMBRANOSO (BASAL CELL tumor con un patrón que ADENOCARCINOMA presenta bandas MEMBRANOUS PATTERN): interconectadas de células tumor con un patrón similar al basaloides, a veces se observan sólido, pero con grandes luces rodeadas por células cantidades de material tipo ductales y pseudoquistes lámina basal, que se disponen pequeños, lo que determina una como gotas intercelulares y imagen tubular – trabecular. membranas periféricas de aspecto hialino eosinófilo y PAS ADENOCARCINOMA DE positivo. CELULAS BASALES TIPO TUBULAR (BASAL CELL ADENOCARCINOMA DE ADENOCARCINOMA TUBULAR CELULAS BASALES TIPO PATTERN): tumor con un SOLIDO (BASAL CELL patrón poco común donde se ADENOCARCINOMA SOLID observan luces prominentes PATTERN): tumor con un revestidas por células ductales patrón donde se observan nidos cuboideas. o láminas de forma y tamaño 8 ADENOCARCINOMA DE mucinas, dentro de CELULAS CLARAS (CLEAR compartimientos delimitados CELL ADENOCARCINOMA): por bandas de tejido conectivo tumor epitelial maligno que fibroso bien desarrolladas. presenta una población monomorfa de células claras en ADENOCARCINOMA NO cortes coloreados
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