VOLUME 50, NO. 1 | 2017

ALDRICHIMICA ACTA Acta Archive Indexes

• Chronological • Affiliations

4-Substituted Prolines: Useful Reagents in Enantioselective HIMIC IC A R A Synthesis and Conformational Restraints in the Design of D C L T Bioactive Peptidomimetics A A • Authors • Painting Clues Recent Advances in Alkene Metathesis for Natural Product Synthesis—Striking Achievements Resulting from Increased Sophistication in Catalyst Design and Synthesis Strategy • Titles

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Chronological YEAR Vol. No. Authors Title Affiliation 1968 1 1 Buth, William F. Fragment Information Retrieval of Structures Aldrich Chemical Co., Inc. 1 Bader, Alfred Chemistry and Art Aldrich Chemical Co., Inc. 1 Higbee, W. Edward A Portrait of Aldrich Chemical Company Aldrich Chemical Co., Inc. 2 West, Robert Squaric Acid and the Aromatic Oxocarbons University of Wisconsin at Madison 2 Bader, Alfred Of Things to Come Aldrich Chemical Co., Inc. 3 Koppel, Henry The Compleat Chemists Aldrich Chemical Co., Inc. 3 Biel, John H. Biogenic Amines and the Emotional State Aldrich Chemical Co., Inc. 4 Biel, John H. Chemistry of the Quinuclidines Aldrich Chemical Co., Inc. Warawa, E.J. 4 Clark, Anthony M. Dutch Art and the Aldrich Collection Aldrich Chemical Co., Inc. 1969 2 1 May, Everette L. The Evolution of Totally Synthetic, Strong Analgesics National Institutes of Health 1 Anonymous Computer Aids Search for R&D Chemicals Reprinted from C&EN 1968, 46 (Sept. 2), 26-27 2 Hopps, Harvey B. The Wittig Reaction Aldrich Chemical Co., Inc. Biel, John H. 2 Bader, Alfred R. Prague Revisited Aldrich Chemical Co., Inc.

To Search, press CTRL+F 1 YEAR Vol. No. Authors Title Affiliation 1970 3 1 Bader, Alfred R. Thallium Chemistry: A Study in International Cooperation Aldrich Chemical Co., Inc. 1 Taylor, Edward C. Organothallium Chemistry—New Horizons in Synthesis Princeton University & U. of East Anglia McKillop, Alexander 2 Klundt, Irwin L. Synthesis of Benzocyclobutene and Derivatives Aldrich Chemical Co., Inc. 2 Friess, S. L. Steroidal Saponin Esters Elaborated by Poisonous Marine Echinoderms Naval Medical Research Institute 3 Fergason, James L. Liquid Crystals and Science Kent State University 3 Bader, Alfred R. Liquid Crystals and Modern Art Aldrich Chemical Co., Inc. 4 Daly, John Batrachotoxin, a Novel Steroidal Alkaloid with Selective Effects on National Institutes of Health Witkop, Bernhard Biomembrane Permeability 4 Hopps, Harvey B. Preparation and Reactions of Diazomethane Aldrich Chemical Co., Inc. 1971 4 1 Pedersen, Charles J. Macrocyclic Polyethers for Complexing Metals E.I. Du Pont de Nemours & Co., Inc. 2 Bader, Alfred Cornelis Bega’s Alchemist: A Problem in Art History Aldrich Chemical Co., Inc. 2 Ferosie, Ishak Isonitriles Aldrich Chemical Co., Inc. 3 Anonymous Special Reagents for Thiol Groups Aldrich Chemical Co., Inc. 4 Campbell, John R. Lanthanide Chemical Shift Reagents Aldrich Chemical Co., Inc. 4 Epton, R. Improving Nature’s Catalysts Koch-Light Laboratories, Ltd. Thomas, T.H. 1972 5 1 Li, J.P. Bifunctional Catalysis Aldrich Chemical Co., Inc. 1 Anonymous Better Computer Searches from Aldrich Aldrich Chemical Co., Inc. 2 Cox, James R., Jr. Deuterium Analysis and Organic Chemistry University of Houston Willcott, M.Robert, III 2 Campbell, John The Determination of Optical and Enantiomeric Purity by Nuclear Magnetic Aldrich Chemical Co., Inc. Resonance Spectroscopy (NMR) 3 Kiesow, L. A. A Biologic Assimilation of Inorganic Energy Naval Medical Research Institute 3 May, Everette L. The Methadone Story National Institutes of Health 1973 6 1 Lipowitz, Jonathan The Use of Polymethylhydrosiloxane (PMHS) as a Reducing Agent for Organic Dow Corning Corp. Bowman, Sheryl A. Compounds 1 Olah, George A. Carbocation and Onium Ion Reagents Case Western Reserve University 2 Lane, Clinton F. The Versatile Boranes Aldrich-Boranes, Inc. 3 Wiswesser, W.J. Chemical Information Management for the 21st Century Fort Detrick 3 Lane, Clinton F. The Borane-Amine Complexes Aldrich-Boranes, Inc.

To Search, press CTRL+F 2 YEAR Vol. No. Authors Title Affiliation 1974 7 1 Chignell, Colin F. The Application of Electron Spin Resonance and Spin-Labeling in Biochemistry National Heart and Lung Institute and Pharmacology 1 Lane, Clinton F. Organic Synthesis via Organoboranes: II. Selective Reductions Using Borane- Aldrich-Boranes, Inc. Tetrahydrofuran Complex 1 Anonymous A Brief Survey of Polymer Chemistry Aldrich Chemical Co., Inc. 2 Look, Melvin Hexachlorocyclopentadiene Adducts of Aromatic Compounds and their Hyman Laboratories, Inc. Reaction Products 2 Lane, Clinton F. Organic Synthesis via Organoboranes: III. Ester Reductions with Super- Aldrich-Boranes, Inc. Hydride 2 Griffiths, David W. The Aldrich First System of Information Retrieval Aldrich Chemical Co., Inc. 3 Brown, Herbert C. New Reagents for Hydroboration and for Synthesis via Boranes Purdue University 3 Krishnamurthy, S. Trialkylborohydrides as New Versatile Reducing Agents in Organic Synthesis Purdue University 1975 8 1 Lane, Clinton F. Sodium Cyanoborohydride: A Highly Selective Reducing Agent Aldrich-Boranes, Inc. 2 Kabalka, George W. Organoboranes in Organic Synthesis University of Tenessee at Knoxville 2 Lane, Clinton F. Organic Synthesis via Organoboranes: IV. Reduction of Organic Functional Aldrich-Boranes, Inc. Groups with Borane-Methyl Sulfide 3 Anonymous Chemical Reactions of Polymers Aldrich Chemical Co., Inc. 4 Harvey, David R. Highlights Aldrich Chemical Co., Inc. 1976 9 1 Gokel, George W. Crown Ether Chemistry: Principles and Applications The Pennsylvania State U. and State U Durst, H. Dupont of New York at Buffalo 1 Crosby, Guy A. Polymeric Reagents Dynapol 2 Epton, Roger Permeation Chromatography of Organic Solutes Using Enzacryl Gel Packings Koch-Light Laboratories, Ltd. 2 Lane, Clinton F. Selective Reduction of the Carbonyl Group in α,β-Unsaturated Aldehydes and Aldrich-Boranes, Inc. Ketones 3 Jones, R. Alan Applications of Phase-Transfer Catalysis in Organic Synthesis University of East Anglia 3 Bader, Alfred Recent Advances in Synthetic Pyrethroids Aldrich Chemical Co., Inc. 1977 10 1 Dolphin, David Robert Burns Woodward: Three Score Years and Then? University of British Columbia 1 Lane, Clinton F. Handling Air-Sensitive Reagents Aldrich-Boranes, Inc. & Purdue U. Kramer, Gary W. 2 Szabo, William A. Chlorosulfonyl Isocyanate: Silver Anniversary of a Lively Heterocumulene Aldrich Chemical Co., Inc. 3 Smith, Ian C.P. Deuterium NMR—A Useful Technique in Chemistry, Physics, and Biology National Research Council of Canada 3 Lane, Clinton F. Selective Reductions Using Borane Complexes Aldrich-Boranes, Inc. 4 Kime, Katherine A. A Practical Guide to Uses of Lanthanide NMR Shift Reagents University of Colorado Sievers, Robert E. 4 Newaz, S.S. Recent Methods for the Synthesis of Conjugated Lactones Aldrich Chemical Co., Inc.

To Search, press CTRL+F 3 YEAR Vol. No. Authors Title Affiliation 1978 11 1 Green, Floyd J. A Status Report on Biological Stains Aldrich Chemical Co., Inc. 1 Beschke, Helmut Chemical Reactions of 2,3-Cycloalkenopyridines Degussa 2 Masamune, Satoru Recent Progress in Macrolide Synthesis University of Alberta 3 Clive, Derrick L. J. Selenium Reagents for Organic Synthesis University of Alberta 3 Block, Eric Organic Sulfur Compounds in Organic Synthesis: Some Recent Advances University of Missouri at St. Louis 1979 12 1 Brown, Herbert C. Boranes for Organic Reductions—A Forty-Year Odyssey Purdue University Krishnamurthy, S. 1 Gladysz, J. A. Trialkylborohydrides in Organometallic Syntheses University of California at Los Angeles 2 Evans, C. Anderson Spin Trapping Varian Associates 2 Greenlee, Kenneth W. A Small Chemical Businessman Looks at Premanufacture Notification (PMN) Chemsampco, Inc. 3 Olah, George A. New Synthetic Reagents and Reactions University of Southern California at Los Angeles 3 Rylander, Paul N. Choosing and Using Noble Metal Hydrogenation Catalysts Engelhard Minerals and Chemicals Corp. 4 Sharpless, K. Barry Metal-Catalyzed, Highly Selective Oxygenations of Olefins and Acetylenes with Stanford University Verhoeven, Thomas R. tert-Butyl Hydroperoxide. Practical Considerations and Mechanisms. 4 Levin, Robert H. Tilorone, Its Analogs, and Developments in Chemical Immunology Consultant (Research & Management) 1980 13 1 Wallace, Raymond G. Hydroxylamine-O-sulfonic Acid—A Versatile Synthetic Reagent Brunel University 1 Szabo, William A. Chiral Starting Materials and Reagents—An Outline of Recent Synthetic Aldrich Chemical Co., Inc. Lee, H.T. Applications 2 Kishi, Yoshito Recent Developments in the Chemistry of Natural Products Harvard University 2 Schiessl, Henry W. Hydrazine—Rocket Fuel to Synthetic Tool Olin Corporation 3 Magnus, Philip Organosilicon Reagents for Carbon-Carbon Bond-Forming Reactions Ohio State University, The 3 Sjoeberg, Kjell PTC in PracTiCe Royal Institute of Technology 1981 14 1 Brown, Herbert C. Synthesis and Applications of Vinylic Organoboranes Purdue University Campbell, James B., Jr. 1 Beschke, Helmut Chemical Reactions of Newly Available Pyridines Degussa 2 Dawson, D.J. Polymeric Dyes Dynapol 2 Schmidt, Arthur H. Bromotrimethylsilane and Iodotrimethylsilane—Versatile Reagents for Organic Fachhochschule Fresenius Synthesis 3 Trost, Barry M. Transition-Metal Templates for Selectivity in Organic Synthesis University of Wisconsin at Madison 3 Wiersum, U.E. Isobenzofuran and Related o-Quinonoid Systems—A New Group of Synthetic Akzo Research Labs, The Netherlands Intermediates 4 Long, John R. The Role of Silver Salts in Organic Processes Aldrich Chemical Co., Inc. 4 Hase, Tapio A. A Compilation of References on Formyl and Acyl Anion Synthons University of Helsinki Koskimies, Jorma K.

To Search, press CTRL+F 4 YEAR Vol. No. Authors Title Affiliation 1982 15 1 Hoffman, Frances Gilbert Stork: A Celebration of 35 Years in Research & Teaching Columbia University 1 Black, T. Howard Recent Applications of Homogeneous Catalysis to Organic Synthesis Aldrich Chemical Co., Inc. 2 Evans, David A. Studies in Asymmetric Synthesis. The Development of Practical Chiral Enolate California Institute of Technology Synthons 2 Hase, Tapio A. A Compilation of References on R-Functional Acyl Anion Synthons, RCO- University of Helsinki Koskimies, Jorma K. 3 Masamune, Satoru Advances in Stereochemical Control: The 1,2- and 1,3-Diol Systems Massachusetts Institute of Technology Choy, William 1983 16 1 Black, T. Howard The Preparation and Reactions of Diazomethane Aldrich Chemical Co., Inc. 1 Stang, Peter J. Triflic Acid and Its Derivatives University of Utah White, Mitchell R. 2 Whitesides, George M. Enzymes as Catalysts in Organic Synthesis Harvard University Wong, C.-H. 2 Balding, Peter Lectins Sigma- London Humphryes, Ken C. 2 Frost, John W. 5-Thio-D-glucose: How Do Enzymes Work? Harvard University 3 Crockett, Geoffrey C. The Chemical Synthesis of DNA Aldrich Chemical Co., Inc. 3 Gill, Steven K. New Developments in Chemiluminescence Research Liquid Light Laboratories 4 Behrens, Carl H. New Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Easy Massachusetts Institute of Technology Sharpless, K. Barry Routes to Homochiral Substances 1984 17 1 Cori, Tom Our Chemist-Collector Approaches Sixty Sigma-Aldrich Corp., M. Emanuel, Emanuel, Ralph N.; Harvey, David; Ltd., Aldrich Chemical Co., and Foley Klitsner, Marvin E. & Lardner 1 Daub, Guido H. The Use of Acronyms in Organic Chemistry University of New Mexico, Harvey Leon, Alberto A.; Silverman, I. Mudd College, and Imperial Chemical Robert; Daub, G. William; Walker, S. Industries Barrie 2 Wiersum, U.E. Preparative Flash-Vacuum Thermolysis. The Revival of Pyrolytic Synthesis Akzo Research Labs, The Netherlands 2 Paquette, Leo A. Synthetic Routes to Cyclopentanoid-Fused Unnatural and Natural Products Ohio State University 3 Deslongchamps, Pierre The Concept of Strategy in Organic Synthesis Universite de Sherbrooke 3 Bristow, Garry S. Tin Reagents for Organic Synthesis Aldrich Chemical Co, Ltd. (England)

To Search, press CTRL+F 5 YEAR Vol. No. Authors Title Affiliation 1985 18 1 Johnson, Carl R. Applications of Sulfoximines in Synthesis Wayne State University 1 Leete, Edward The Use of Carbon-13-Labeled Compounds in Organic Chemistry, Biochemistry University of Minnesota and Aldrich Porwoll, Joseph and Medicine Chemical Co., Inc. 1 Harwood, Lawrence M. Dry-Column Flash Chromatography Oxford University 2 Negishi, Ei-ichi Organozirconium Compounds as New Reagents and Intermediates Purdue University Takahashi, Tamotsu 3 Meyers, Albert I. Formamidines as Precursors to α-Amino Carbanions and their Application to Colorado State University Asymmetric C-C Bond-Forming Reactions 3 Bryce, Martin R. Tetrathiafulvalenes (TTF) and their Selenium and Tellurium Analogs (TSF and TTeF): Electron Donors for Organic Metals 4 Long, John R. Lanthanides in Organic Synthesis 4 Mickel, Stuart 4-Acetoxy-2-azetidinone: A Useful Heterocyclic Synthon 4 Griffiths, David W. The Aldrich FIRST System of Information Retrieval—An Update Aldrich Chemical Co., Inc. 1986 19 1 Williams, Dudley H. Ralph Alexander Raphael: A Lover of Acetylenes at 65 Cambridge University 1 Kabalka, George W. The Synthesis of Labeled Compounds via Organoboranes University of Tennessee at Knoxville 2 Gill, G. B. Guidelines for Handling Air-Sensitive Compounds University of Nottingham Whiting, D.A. 2 Gupton, John T. Some Useful Synthetic Applications of Gold’s Reagent University of Central Florida 2 Szafran, Zvi The Use of the Aldrich-Nicolet IR Peak-Search and Retrieval Programs in Merrimack College Pike, Ronald M. and Davis, J. David Introductory Chemical Instrumentation 3 Danishefsky, Samuel J. Reflections on Organic Synthesis: The Evolution of a General Strategy for the Yale University Stereoselective Construction of Polyoxygenated Natural Products 1987 20 1 Brewster, James H. To Live for Wisdom—An Appreciation of Herbert C. Brown Purdue University 1 Srebnik, Morris The Utility of Chiral Organoboranes in the Preparation of Optically Active Aldrich Chemical Co., Inc. and Purdue Ramachandran, P. Veeraraghavan Compounds University 1 Davenport, Derek A. On Opinion in Good Men: An Oblique Tribute to H.C. Brown Purdue University 2 Crich, David O-Acyl Thiohydroxamates: New and Versatile Sources of Alkyl Radicals for Use University College London in Organic Synthesis 2 Yamamoto, Yoshinori Allylic Tin Compounds in Organic Synthesis Tohoku University 3 Wasserman, Harry H. New Methods in the Formation of Macrocyclic Lactams and Lactones of Yale University Biological Interest

To Search, press CTRL+F 6 YEAR Vol. No. Authors Title Affiliation 1988 21 1 Hewitt, Christopher D. Fluoroaromatic Compounds: Synthesis, Reactions and Commercial Applications Aldrich Chemical Co., Inc. Silvester, Michael J. 1 Bader, Alfred How to Find a Great Herbicide Aldrich Chemical Co., Ltd. (England) 2 Abdulla, Riaz F. Ultrasound in Organic Synthesis Lilly Research Laboratories 3 Ireland, Robert E. Synthetic Methodology in the Context of Natural Product Total Synthesis University of Virginia, The 3 Dervan, Peter B. John D. Roberts California Institute of Technology 4 Bruice, Thomas C. The Mechanisms of Oxygen Transfer from Acyl and Alkyl Hydroperoxides University of California at Santa to Metal(III) Porphyrins and the Epoxidation of Alkenes by the Resultant Barbara Hypervalent Metal-Oxo Porphyrin Products 4 Laszlo, Pierre CLAYCOP, a User-Friendly Oxidizing and Nitrating Reagent Universite de Liege Cornelis, Andre 4 Yau, Eric K. Filtering-Column Chromatography—A Fast, Convenient Chromatographic University of Michigan Coward, James K. Method 1989 22 1 Hanessian, Stephen Design and Implementation of Tactically Novel Strategies for Stereochemical Universite de Montreal Control Using the Chiron Approach 1 Wiswesser, William J. Johann Josef Loschmidt (1821-1895): A Forgotten Genius. Benzene Rings and Weed Science Research Lab (USDA) Much More in 1861 2 Massey, A.G. The Direct Synthesis of Non-Transition-Metal Organo Derivatives University of Technology Humphries, R. E. (Loughborough) and U. of New Brunswick (St. John) 2 Seoane, Carlos Teaching Organic Synthesis: Why, How, What? Universidad de Castilla-La Mancha 3 Knowles, Jeremy R. Mechanistic Ingenuity in Enzyme Catalysis: Dehydroquinate Synthase Harvard University 3 Ingold, Keith U. At the Organic Chemistry/Bioscience Interface: Rate Processes in National Research Council of Canada Complex Systems 1990 23 1 Barton, Derek H. R. The Invention of Chemical Reactions Texas A&M University 1 Griffith, William P. TPAP: Tetra-n-propylammonium Perruthenate, a Mild and Convenient Oxidant Imperial College of Science, Ley, Steven V. for Alcohols Technology and Medicine

2 Davies, Stephen G. The Chiral Auxiliary [(C5H5)Fe(CO)(PPh3)] for Asymmetric Synthesis Dyson Perrins Laboratory 2 Kulkarni, Yashwant S. Carboxyolefination Aldrich Chemical Co., Inc. 3 Prelog, Vladimir Albert Eschenmoser Eidgenoessischen Technischen Hochschule 3 Kornblum, Nathan Synthetic Aspects of Electron-Transfer Chemistry Purdue University 4 Gray, Harry B. Long-Range Electron Transfer in Proteins California Institute of Technology 4 Heathcock, Clayton H. Understanding and Controlling Diastereofacial Selectivity in Carbon-Carbon University of California at Berkeley Bond-Forming Reactions

To Search, press CTRL+F 7 YEAR Vol. No. Authors Title Affiliation 1991 24 1 Alper, Howard Simple, Novel Methods for the Synthesis of Carbonyl Compounds Using Metal University of Ottawa Complexes as Catalysts 1 Soderquist, John A. Samarium(II) Iodide in Organic Synthesis University of Puerto Rico 2 Silvester, Michael J. Fluoroheterocyclic Compounds: Synthesis, Reactions, and Commercial Aldrich Chemical Co., Ltd. (England) Applications 2 Deslongchamps, Pierre Transannular Diels-Alder Reaction on Macrocycles: A General Strategy for the Universite de Sherbrooke Synthesis of Polycyclic Compounds 3 Grieco, Paul A. Organic Chemistry in Unconventional Solvents Indiana University 3 Williams, Dudley H. The Molecular Basis of Biological Order University of Cambridge 1992 25 1 Abeles, Robert H. A Methionine Salvage Pathway Brandeis University 1 Williams, Dudley H. The Molecular Basis of Biological Order and Amide-Amide Hydrogen Bonds-An University of Cambridge Addendum 1 Williams, Robert M. Asymmetric Syntheses of α-Amino Acids Colorado State University 2 Newkome, George R. Building Blocks for Dendritic Macromolecules University of South Florida Moorefield, Charles N.; Baker, Gregory R. 2 Fu, Xiaoyong The Synthesis of Polyquinanes and Polyquinenes via the Weiss Reaction University of Wisconsin at Milwaukee Cook, James M. 3 Seebach, Dieter How We Stumbled into Peptide Chemistry Eidgenoessischen Technischen Hochschule 3 Motherwell, William B. A Curiosity Driven Search for New Chemical Reactions Imperial College of Science, Technology and Medicine 1993 26 1 Fry, Albert J. Electrochemistry in Organic Synthesis Wesleyan University 1 Pereira, Schubert The Ireland-Claisen Rearrangement University of Toledo Srebnik, Morris 2 Heaney, Harry Oxidation Reactions Using Magnesium Monoperphthalate and Urea Hydrogen Loughborough U. of Technology Peroxide 2 Mascaretti, Oreste A. Modern Methods for the Monofluorination of Aliphatic Organic Compounds. CONICET-Universidad Nacional de Nucleophilic Fluoride Transfer Agents Rosario 3 Nicolaou, K.C. New Synthetic Methods and Strategies and Total Synthesis of Natural University of California at San Diego Products 4 Tomalia, Donald A. Starburst/Cascade Dendrimers: Fundamental Building Blocks for a New Michigan Molecular Institute Nanoscopic Chemistry Set 4 Jones, J. Bryan Probing the Specificity of Synthetically Useful Enzymes University of Toronto

To Search, press CTRL+F 8 YEAR Vol. No. Authors Title Affiliation 1994 27 1 Editorial Staff Correction to Starburst/Cascade Dendrimers: Fundamental Building Blocks for Aldrich Chemical Co., Inc. a New Nanoscopic Chemistry Set 1 Juaristi, Eusebio Enantioselective Synthesis of β-Amino Acids Instituto Politecnico Nacional (Mexico) Quintana, Delia; Escalante, Jaime 1 Prakash, Om Iodobenzene Diacetate and Related Hypervalent Iodine Reagents in the Kurukshetra University Singh, Shiv P. Synthesis of Heterocyclic Compounds 2 Katritzky, Alan R. Benzotriazole-Stabilized Carbanions: Generation, Reactivtiy, and Synthetic University of Florida Yang, Zhijun; Cundy, Darren J. Utility 2 Dhar, Raj K. Diisopinocampheylchloroborane, (DIP-Chloride), an Excellent Chiral Reducing Aldrich Chemical Co., Inc. Reagent for the Synthesis of Secondary Alcohols of High Enantiomeric Purity 3 Editor Correct Structures for Benzyl (+)- and (-)-glycidyl ether Aldrich Chemical Co., Inc. 3 De Keukeleire, Denis The Synthetic Potential of the Intramolecular meta-Photocycloaddition in University of Gent Arene-Alkene Bichromophoric Systems Containing Oxygen in the Tether 3 Cornforth, John Warcup The Trouble with Synthesis University of Sussex 1995 28 1 Gutsche, C. David Calixarenes Texas Christian U. 1 Brown, Tom Mismatches and Mutagenic Lesions in Nucleic Acids University of Southampton 2 McClinton, Martin A. Triethylamine Tris(hydrogen fluoride): Applications in Synthesis FAR Research Inc. 2 Hall, H.K., Jr. Spontaneous Polymerizations Can Occur During Cycloaddition Reactions of University of Arizona Padias, Buyle Olefins and Dienes 2 Silvester, Michael J. Polyfluorinated Alkenes, Alkynes, and Allenes Sigma-Aldrich Chemical Co., Ltd. 3 Prakash, Om Organo Iodine(III) and Thallium(III) Reagents in Organic Synthesis: Useful Kurukshetra University Methodologies Based on Oxidative Rearrangements 3 Marshman, Robert W. Rare Earth Triflates in Organic Synthesis Aldrich Chemical Co., Inc. 3 Recatto, Craig A. The Intermediacy of Transition-Metal Silicon-Bonded Complexes: Recent Aldrich Chemical Co., Inc. Developments 4 Marchand, Alan P. Polycyclic Cage Compounds: Reagents, Substrates, and Materials for the 21st University of North Texas Century 4 Overman, Larry E. New Reactions for Forming Heterocycles and Their Use in Natural Products University of California at Irvine Synthesis

To Search, press CTRL+F 9 YEAR Vol. No. Authors Title Affiliation 1996 29 1 Doyle, Michael P. Chiral Dirhodium Carboxamidates: Catalysts for Highly Enantioselective Trinity University Syntheses of Lactones and Lactams 1 Sabitha, Gowravaram 3-Formylchromone as a Versatile Synthon in Heterocyclic Chemistry Indian Institute of Chemical Technology 2 Hormann, Robert E. Nonnatural Products Nonpareil Rohm and Haas Co. 2 Bashir-Hashemi, A. Oxalyl Chloride in Photochemical Chlorocarbonylation of Cage Compounds GEO-Centers, Inc. at ARDEC Doyle, Gerald 2 Koganti, Vara Prasad Atlas of Organic Conversions: An Aid in Perspective New Science College 3 Mukaiyama, Teruaki New Possibilities in Organic Synthesis Science University of Tokyo 1997 30 1 Ager, David J. Chiral Oxazolidinones in Asymmetric Synthesis NSC Technologies & NutraSweet Kelco Prakash, Indra; Schaad, David R. Co. (Units of Monsanto) 1 Donaldson, William A. Preparation and Reactivity of Acyclic (Pentadienyl)iron(1+) Cations: Marquette University Applications to Organic Synthesis 2 Dondoni, Alessandro Thiazole-Based Routes to Amino Hydroxy Aldehydes, and Their Use for the Universita di Ferrara Perrone, Daniela Synthesis of Biologically Active Compounds 2 Mascaretti, Oreste A. Esterifications, Transesterifications, and Deesterifications Mediated by CONICET-UNR Furlan, Ricardo L.E. Organotin Oxides, Hydroxides, and Alkoxides 3 Seeberger, P.H. Synthesis of Biologically Important Oligosaccharides and Other Sloan-Kettering Institute for Cancer Bilodeau, M.T.; Danishefsky, S.J. Glycoconjugates by the Glycal Assembly Method Research 3 Radl, Stanislav Crisscross Cycloaddition Reactions Research Institute for Pharmacy and Biochemistry (Prague) 4 Davies, Huw M.L. Asymmetric Synthesis Using Rhodium-Stabilized Vinylcarbenoid Intermediates State University of New York at Buffalo 4 Warrener, Ronald N. Dimethyl Tricylclo[4.2.1.02,5]nona-3,7-diene-3,4-dicarboxylate: A Versatile Central Queensland University Butler, Douglas N. Ambident Dienophile 1998 31 1 Senanayake, Chris H. Applications of cis-1-Amino-2-indanol in Asymmetric Synthesis Sepracor, Inc. 1 Narasimhan, S. Balakumar, R. Synthetic Applications of Zinc Borohydride Centre for Agrochem. Res. (Guindy, India) 2 Katritzky, Alan R. Benzotriazole-Based Intermediates: Reagents for Efficient Organic Synthesis University of Florida, Gainsville Belyakov, Sergei A. 2 Melikyan, Gagik G. Manganese-Based Organic and Bioinorganic Transformations California State University, Northridge 3 Bosnich, Brice Transition-Metal-Based Lewis Acid Catalysts University of Chicago 1999 32 1 Barluenga, Jose Chiral Heterosubstituted 1,3-Butadienes: Synthesis and [4+2] Cycloaddition Universidad de Oviedo Suarez-Sobrino, A.; Lopez, Luis A. Reactions 1 Kulkarni, Yashwant S. Serine Derivatives in Organic Synthesis Aldrich Chemical Co., Inc. 2 Hudlicky, Tomas Enzymatic Dihydroxylation of Aromatics in Enantioselective Synthesis: University of Florida, Gainsville; Gonzalez, David; Gibson, David T. Expanding Asymmetric Methodology University of Iowa, Iowa City 3 Phillips, Andrew J. Ring-Closing Metathesis of Nitrogen-Containing Compounds: Applications to University of Canterbury, New Zealand Abell, Andrew D. Heterocycles, Alkaloids, and Peptidomimetics 3 Sibi, Mukund P. Are Two Phenyls Better than One? Synthesis and Applications of (R)-4- North Dakota State University Diphenylmethyl-2-oxazolidinone

To Search, press CTRL+F 10 YEAR Vol. No. Authors Title Affiliation 2000 33 1 Winter, Charles H. The Chemical Vapor Deposition of Metal Nitride Films Using Modern Wayne State University Metalorganic Precursors 1 Babu, G. Perumal, P. T. Synthetic Applications of Indium Trichloride Catalyzed Reactions Central Leather Research Institute (Chennai, India) 1 Hopps, Harvey B. Purpald®: A Reagent That Turns Aldehydes Purple! Amarillo College 2 Adams, Richard D. The Catalytic Synthesis of Thiacrowns from Thietanes and Thiiranes by Metal University of South Carolina Carbonyl Complexes 2 Rieke, Reuben D. The Preparation of Highly Reactive Metals and the Development of Novel Rieke Metals, Inc. Organometallic Reagents 2 Comasseto, Joao V. Add a Little Tellurium to Your Synthetic Plans! Universidade de Sao Paulo Barrientos-Astigarraga, Rafael E. 3 Toy, Patrick H. Tailoring Polystyrene Solid-Phase Synthesis Resins: Incorporation of Flexible The Scripps Research Institute Reger, Thomas S.; Janda, Kim D. Cross-Linkers 3 Curran, Dennis P. Highlights from Two Decades of Synthetic Radical Chemistry University of Pittsburgh 2001 34 1 O’Donnell, Martin J. The Preparation of Optically Active α-Amino Acids from the Benzophenone Indiana University Purdue University Imines of Glycine Derivatives Indianapolis (IUPUI) 1 Milata, Viktor Alkoxymethylenemalonates in Organic Synthesis Slovak Technical University 2 Firsan, Sharbil J. A Half Century of Chemists Helping Chemists: Aldrich from 1951 to 2001 Aldrich Chemical Co., Inc. 2 Gilchrist, Thomas L. Activated 2H-Azirines as Dienophiles and Electrophiles The University of Liverpool 2 Amery, Gordon Reactive Chemical Hazard Evaluation in the Scale-Up of Chemical Processes Sigma-Aldrich Company Ltd. (Gillingham) 3 Lebreton, S. Solid-Phase Dendrimer Chemistry: Synthesis and Applications University of Southampton Monaghan, S.; Bradley, M. 3 Koser, Gerald F. [Hydroxy(tosyloxy)iodo]benzene and Closely Related Iodanes: The Second The University of Akron Stage of Development 2002 35 1 Firsan, Sharbil J. Herbert C. Brown and Aldrich Aldrich Chemical Co., Inc. 1 Cho, Byung Tae Boron-Based Reducing Agents for the Asymmetric Reduction of Functionalized Hallym University (Korea) Ketones and Ketimines 1 Ramachandran, P. Veeraraghavan Pinane-Based Versatile Allylboranes Purdue University

2 Lauret, Christelle Asymmetric Epoxidation of α, β-Unsaturated Ketones Catalyzed by Poly(amino The University of Liverpool Roberts, Stanley M. acids) 2 Kanth, Josyula V. B. Borane-Amine Complexes for Hydroboration Aldrich Chemical Co., Inc. 3 Zhao, Hua Applications of Ionic Liquids in Organic Synthesis New Jersey Institute of Technology Malhotra*, Sanjay V. 3 Periasamy, Mariappan Novel Methods of Resolving Racemic Diols and Amino Alcohols University of Hyderabad

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5 + 2003 36 1 Redlich, Mark D. Iron Lewis Acid [(η -C5H5)Fe(CO)2(THF)] Catalyzed Organic Reactions University of Wisconsin-Milwaukee Mayer, Michael F.; Hossain, M. Mahmun 1 Murugan, Ramiah Applications of Dialkylaminopyridine (DMAP) Catalysts in Organic Synthesis Reilly Industries, Inc. 2 Cardillo, Giuliana Aziridines and Oxazolines: Valuable Intermediates in the Synthesis of Unusual Universita di Bologna Gentilucci, Luca; Tolomelli, Amino Acids Alessandra 2 Lee, Won Koo Highlights of the Chemistry of Enantiomerically Pure Aziridine-2-carboxylates Sogang University; Hankuk University Ha, Hyun-Joon of Foreign Studies (Korea) 3 Denmark, Scott E. Organosilicon Reagents: Synthesis and Application to Palladium-Catalyzed University of Illinois at Urbana- Ober, Michael H. Cross-Coupling Reactions Champaign 3 Vernall, Andrea J. Cross Metathesis of Nitrogen-Containing Systems University of Canterbury Abell, Andrew D. 2004 37 1 Verkade, John G. Recent Applications of Proazaphosphatranes in Organic Synthesis Iowa State University and Albany Kisanga, Philip B. Molecular Research, Inc. 1 McNab, Hamish Chemistry Without Reagents: Synthetic Applications of Flash Vacuum Pyrolysis The University of Edinburgh 2 Tomalia, Donald A. Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Dendritic NanoTechnologies, Inc., Blocks for Nanoscale Synthetic Organic Chemistry Central Michigan University 2 Hayes, Brittany L. Recent Advances in Microwave-Assisted Synthesis CEM Corporation 3 Fukuyama, Tohru Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters The University of Tokyo Tokuyama, Hidetoshi 3 Roesky, Herbert W. Hydroalumination Reactions in Organic Chemistry The University of Goettingen 2005 38 1 Harned, Andrew M. ROM Polymerization in Facilitated Synthesis The University of Kansas Zhang, Mianji; Vedantham, Punitha; Mukherjee, Shubhasish; Herpel, Russell H.; Flynn, Daniel L.; Hanson, Paul R. 1 Pears, David A. Polyurea-Encapsulated Palladium Catalysts: The Development and Application Avecia Pharmaceuticals and Syngenta Smith, Stephen C. of a New and Versatile Immobilized-Homogeneous- Catalyst Technology 2 Lane, Clinton F. Herbert C. Brown and Aldrich: Advancing Borane Chemistry for 32 Years Northern Arizona University 2 Molander, Gary A. Organotrifluoroborates: Expanding Organoboron Chemistry The University of Pennsylvania Figueroa, Ruth 2 Pasumansky, Lubov Recent Advances in the Chemistry of Lithium Aminoborohydrides University of California, Santa Cruz Singaram, Bakthan; Goralski, Christian T. 3 Negishi, Ei-ichi Palladium-Catalyzed Alkenylation by the Negishi Coupling Purdue University Hu, Qian; Huang, Zhihong; Qian, Mingxing; Wang, Guangwei 3 Senanayake, Chris H. Enantiopure Sulfoxides and Sulfinamides: Recent Developments in Their Boehringer Ingelheim Pharmaceuticals, Krishnamurthy, Dhileepkumar; Lu, Stereoselective Synthesis and Applications to Asymmetric Synthesis Inc. Zhi-Hui; Han, Zhengxu; Gallou, Isabelle

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Wencel-Delord, Joanna; Glorius, of Csp2 C-H Positions with Olefins, Alkynes, and Arenes and Westfalische Wilhelms-Universitat Frank Munster 2 Harrison, Daniel P. Opening New Chemical Space through Novel Dearomatization Reactions University of Virginia Harman, W. Dean 3 Lundgren, Rylan J. Recent Advances in the Buchwald–Hartwig Amination Reaction Enabled by the Dalhousie University Stradiotto, Mark Application of Sterically Demanding Phosphine Ancillary Ligands 3 Jin, Zhuang Transition-Metal-Mediated Fluorination, Difluoromethylation, and University of Louisville Hammond, Gerald B.; Xu, Bo Trifluoromethylation

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To Search, press CTRL+F 17 YEAR Vol. No. Authors Title Affiliation 2016 49 1 Yumei, Xiao; Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for China Agricultural University and The Guo, Hongchao; Kwon, Ohyun Kwon Asymmetric Annulations University of California, Los Angeles 1 Wieting, Joshua M. Silanediol Recognition in Catalysis, Sensing, and Drug Discovery The Ohio State University Hardman-Baldwin, Andrea M.; Visco, Michael D.; Mattson, Anita E. 2 Birman, Vladimir B. Amidine-Based Catalysts (ABCs): Design, Development, and Applications Washington University, St. Louis, MO 2 Varma, Rajender S. Advancing Sustainable Catalysis with Magnetite. Surface Modification and U.S. Environmental Protection Agency Baig, R. B. Nasir; Verma, Sanny; Synthetic Applications Nadagouda, Mallikarjuna N. 3 Senaweera, Sameera Photocatalytic C–F Reduction and Functionalization Oklahoma State University Weaver, Jimmie D. 3 Dallinger, Doris Recent Enabling Technologies for Diazomethane Generation and Reactions University of Graz and the Research Kappe, C. Oliver Center for Pharmaceutical Engineering 2017 50 1 Tolomelli, Alessandra 4-Substituted Prolines: Useful Reagents in Enantioselective Synthesis and “G. Ciamician” University of Bologna Ferrazzano, Lucia; Amoroso, Rosa Conformational Restraints in the Design of Bioactive Peptidomimetics 1 Vanderwal, Christopher D. Recent Advances in Alkene Metathesis for Natural Product Synthesis—Striking University of California, Irvine Atwood, Brian R. Achievements Resulting from Increased Sophistication in Catalyst Design and Synthesis Strategy 2 Chan, Jefferson, Disproportionate Impact of Named Reactions on Chemical Biology University of Illinois at Urbana- Bearrood, Thomas E. Champaign 2 Hermanson, Greg T. Bioconjugation—A Versatile and Essential Research Tool Bioscience Consulting Services 3 Li, Gang, Palladium-Catalyzed meta- and para-C–H Bond Functionalizations Fujian Institute of Research on the Gao, Yuzhen Assisted by a Directing Group Structure of Matter 2018 51 1 Echeverria, Pierre-Georges The Spectacular Resurgence of Electrochemical Redox Reactions in Organic Minakem Recherche Delbrayelle, Dominique; Synthesis Letort, Aurélien; Nomertin, Fiona; Perez, Marc; Petit, Laurent 1 Engle, Keary M. Carbon–Carbon π Bonds as Conjunctive Reagents in Cross-Coupling The Scripps Research Institute Derosa, Joseph; Tran, Van T.; van der Puyl, Vincent A. 2 Collins, Shawn K. Continuous-Flow Macrocyclization Université de Montréal Godin, Éric; Morin, Émilie 2 Colby, David A. Fluoroenolate-Enabled Monofluorinations and Difluoromethylations University of Mississippi Sowaileh, Munia F. 3 Perosa, Alvise Greener and Sustainable Applications of Phosphorus and Sulfur Ylides Università Ca’ Foscari, Venezia (Italy) Cattelan, Lisa; Fiorani, Giulia; Selva, Maurizio

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To Search, press CTRL+F 19 Authors AUTHORS Title Affiliation Year Vol. Abdulla, Riaz F. Ultrasound in Organic Synthesis Lilly Research Laboratories 1988 21 Abeles, Robert H. A Methionine Salvage Pathway Brandeis University 1992 25 Adair, Gareth TRIP—A Powerful Brønsted Acid Catalyst for Asymmetric Synthesis Max-Planck-Institut für 2008 41 Mukherjee, Santanu; List, Benjamin Kohlenforschung Adams, Richard D. The Catalytic Synthesis of Thiacrowns from Thietanes and Thiiranes by Metal University of South Carolina 2000 33 Carbonyl Complexes Ager, David J. Chiral Oxazolidinones in Asymmetric Synthesis NSC Technologies & NutraSweet 1997 30 Prakash, Indra; Schaad, David R. Kelco Co. (Units of Monsanto) Al-Maharik, Nawaf Organofluorine Chemistry: Deoxyfluorination Reagents for C-F Bond Synthesis University of St. Andrews 2011 44 O’Hagan, David Alper, Howard Simple, Novel Methods for the Synthesis of Carbonyl Compounds Using Metal University of Ottawa 1991 24 Complexes as Catalysts Amery, Gordon Reactive Chemical Hazard Evaluation in the Scale-Up of Chemical Processes Sigma-Aldrich Company Ltd. 2001 34 (Gillingham) Amoroso, Dino Aminophosphine Catalysts in Modern Asymmetric Synthesis Kanata Chemical Technologies, Inc. 2008 41 Graham, Todd W.; Guo, Rongwei; Tsang, (Toronto, Canada) Chi-Wing; Abdur-Rashid, Kamaluddin Anastas, Paul T. Green Chemistry Next: Moving from Evolutionary to Revolutionary Center for Green Chemistry and 2015 48 Green Engineering, Yale University Anonymous Computer Aids Search for R&D Chemicals Reprinted from C&EN 1968, 46 1969 2 (Sept. 2), 26-27 Anonymous Special Reagents for Thiol Groups Aldrich Chemical Co., Inc. 1971 4 Anonymous Better Computer Searches from Aldrich Aldrich Chemical Co., Inc. 1972 5 Anonymous A Brief Survey of Polymer Chemistry Aldrich Chemical Co., Inc. 1974 7 Anonymous Chemical Reactions of Polymers Aldrich Chemical Co., Inc. 1975 8 Babu, G. Synthetic Applications of Indium Trichloride Catalyzed Reactions Central Leather Research Institute 2000 33 Perumal, P. T. (Chennai, India) Bader, Alfred R. Chemistry and Art Aldrich Chemical Co., Inc. 1968 1 Bader, Alfred R. Of Things to Come Aldrich Chemical Co., Inc. 1968 1 Bader, Alfred R. Cornelis Bega’s Alchemist: A Problem in Art History Aldrich Chemical Co., Inc. 1971 4 Bader, Alfred R. Recent Advances in Synthetic Pyrethroids Aldrich Chemical Co., Inc. 1976 9 Bader, Alfred R. How to Find a Great Herbicide Aldrich Chemical Co., Ltd. (England) 1988 21 Bader, Alfred R. Prague Revisited Aldrich Chemical Co., Inc. 1969 2 Bader, Alfred R. Thallium Chemistry: A Study in International Cooperation Aldrich Chemical Co., Inc. 1970 3 Bader, Alfred R. Liquid Crystals and Modern Art Aldrich Chemical Co., Inc. 1970 3

To Search, press CTRL+F 20 AUTHORS Title Affiliation Year Vol. Baig, R. B. Nasir Cyclic Sulfamidate Enabled Syntheses of Amino Acids, Peptides, Carbohydrates, U.S. Environmental Protection 2015 48 Nadagouda, Mallikarjuna N.; and Natural Products Agency Varma, Rajender S. Baktharaman, Sivaraj Amino Carbonyl Compounds in Organic Synthesis University of Toronto 2008 41 Hili, Ryan; Yudin, Andrei K. Balding, Peter Lectins Sigma- London 1983 16 Humphryes, Ken C. Bandala, Yamir Recent Advances in the Application of α-Phenylethylamine (α-PEA) in the Instituto Politécnico Nacional 2010 43 Juaristi, Eusebio Preparation of Enantiopure Compounds (México) Barluenga, Jose Chiral Heterosubstituted 1,3-Butadienes: Synthesis and [4+2] Cycloaddition Universidad de Oviedo 1999 32 Suarez-Sobrino, A.; Lopez, Luis A. Reactions Barton, Derek H. R. The Invention of Chemical Reactions Texas A&M University 1990 23 Bashir-Hashemi, A. Oxalyl Chloride in Photochemical Chlorocarbonylation of Cage Compounds GEO-Centers, Inc. at ARDEC 1996 29 Doyle, Gerald Baskin, Jeremy M. Copper-Free Click Chemistry: Bioorthogonal Reagents for Tagging Azides University of California, Berkeley 2010 43 Bertozzi, Carolyn R. Behrens, Carl H. New Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Easy Massachusetts Institute of 1983 16 Sharpless, K. Barry Routes to Homochiral Substances Technology Berkessel, Albrecht Titanium Salalen Catalysts for the Asymmetric Epoxidation of Terminal (and University of Cologne, Germany 2019 52 Other Unactivated) Olefins with Hydrogen Peroxide Beschke, Helmut Chemical Reactions of 2,3-Cycloalkenopyridines Degussa 1978 11 Beschke, Helmut Chemical Reactions of Newly Available Pyridines Degussa 1981 14 Biel, John H. Biogenic Amines and the Emotional State Aldrich Chemical Co., Inc. 1968 1 Biel, John H. Chemistry of the Quinuclidines Aldrich Chemical Co., Inc. 1968 1 Warawa, E.J. Birman, Vladimir B. Amidine-Based Catalysts (ABCs): Design, Development, and Applications Washington University, St. Louis, MO 2016 49 Black, T. Howard Recent Applications of Homogeneous Catalysis to Organic Synthesis Aldrich Chemical Co., Inc. 1982 15 Black, T. Howard The Preparation and Reactions of Diazomethane Aldrich Chemical Co., Inc. 1983 16 Block, Eric Organic Sulfur Compounds in Organic Synthesis: Some Recent Advances University of Missouri at St. Louis 1978 11 Bode, Jeffrey W. SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of ETH-Zürich (Laboratorium für 2015 48 Luescher, Michael U.; Geoghegan, Saturated N-Heterocycles Organische Chemie) Kimberly; Nichols, Paula L. Bosnich, Brice Transition-Metal-Based Lewis Acid Catalysts University of Chicago 1998 31 Boxer, Matthew B. The Super Silyl Group in Diastereoselective Aldol and Cascade Reactions University of Chicago 2009 42 Albert, Brian J.; Yamamoto, Hisashi Brewster, James H. To Live for Wisdom—An Appreciation of Herbert C. Brown Purdue University 1987 20 Bristow, Garry S. Tin Reagents for Organic Synthesis Aldrich Chemical Co, Ltd. (England) 1984 17 Brown, Herbert C. New Reagents for Hydroboration and for Synthesis via Boranes Purdue University 1974 7 Brown, Herbert C. Synthesis and Applications of Vinylic Organoboranes Purdue University 1981 14 Campbell, James B., Jr. Brown, Herbert C. Boranes for Organic Reductions—A Forty-Year Odyssey Purdue University 1979 12 Krishnamurthy, S.

To Search, press CTRL+F 21 AUTHORS Title Affiliation Year Vol. Brown, Tom Mismatches and Mutagenic Lesions in Nucleic Acids University of Southampton 1995 28 Bruice, Thomas C. The Mechanisms of Oxygen Transfer from Acyl and Alkyl Hydroperoxides University of California at Santa 1988 21 to Metal(III) Porphyrins and the Epoxidation of Alkenes by the Resultant Barbara Hypervalent Metal-Oxo Porphyrin Products Bryce, Martin R. Tetrathiafulvalenes (TTF) and their Selenium and Tellurium Analogs (TSF and 1985 18 TTeF): Electron Donors for Organic Metals Buth, William F. Fragment Information Retrieval of Structures Aldrich Chemical Co., Inc. 1968 1 Campbell, John The Determination of Optical and Enantiomeric Purity by Nuclear Magnetic Aldrich Chemical Co., Inc. 1972 5 Resonance Spectroscopy (NMR) Campbell, John R. Lanthanide Chemical Shift Reagents Aldrich Chemical Co., Inc. 1971 4 Campeau, Louis-Charles Recent Advances in Intermolecular Direct Arylation Reactions University of Ottawa (Canada) 2007 40 Stuart, David R.; Fagnou, Keith Cardillo, Giuliana Aziridines and Oxazolines: Valuable Intermediates in the Synthesis of Unusual Universita di Bologna 2003 36 Gentilucci, Luca; Tolomelli, Alessandra Amino Acids Chan, Jefferson, Disproportionate Impact of Named Reactions on Chemical Biology University of Illinois at Urbana- 2017 50 Bearrood, Thomas E. Champaign Chignell, Colin F. The Application of Electron Spin Resonance and Spin-Labeling in Biochemistry National Heart and Lung Institute 1974 7 and Pharmacology Cho, Byung Tae Boron-Based Reducing Agents for the Asymmetric Reduction of Functionalized Hallym University (Korea) 2002 35 Ketones and Ketimines Clark, Anthony M. Dutch Art and the Aldrich Collection Aldrich Chemical Co., Inc. 1968 1 Clive, Derrick L. J. 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To Search, press CTRL+F 31 AUTHORS Title Affiliation Year Vol. Seebach, Dieter How We Stumbled into Peptide Chemistry Eidgenoessischen Technischen 1992 25 Hochschule Seeberger, P.H. Synthesis of Biologically Important Oligosaccharides and Other Glycoconjugates Sloan-Kettering Institute for Cancer 1997 30 Bilodeau, M.T.; Danishefsky, S.J. by the Glycal Assembly Method Research Senanayake, Chris H. Applications of cis-1-Amino-2-indanol in Asymmetric Synthesis Sepracor, Inc. 1998 31 Senanayake, Chris H. Enantiopure Sulfoxides and Sulfinamides: Recent Developments in Their Boehringer Ingelheim 2005 38 Krishnamurthy, Dhileepkumar; Lu, Zhi-Hui; Stereoselective Synthesis and Applications to Asymmetric Synthesis Pharmaceuticals, Inc. Han, Zhengxu; Gallou, Isabelle Senaweera, Sameera Photocatalytic C–F Reduction and Functionalization Oklahoma State University 2016 49 Weaver, Jimmie D. Seoane, Carlos Teaching Organic Synthesis: Why, How, What? Universidad de Castilla-La Mancha 1989 22 Sharpless, K. Barry Metal-Catalyzed, Highly Selective Oxygenations of Olefins and Acetylenes with Stanford University 1979 12 Verhoeven, Thomas R. tert-Butyl Hydroperoxide. Practical Considerations and Mechanisms. Sheldon, Roger A. Biocatalysis and Biomass Conversion in Ionic Liquids Delft University of Technology, The 2015 48 Netherlands Sheldon, Roger A. Cross-Linked Enzyme Aggregates (CLEAs) in Organic Synthesis CLEA Technologies B.V. 2013 46 van Pelt, Sander; Kanbak-Aksu, Seda; Rasmussen, Jo-Anne; Janssen, Michiel H. A. Shibasaki, Masakatsu Chiral, Poly(Rare-Earth-Metal) Complexes in Asymmetric Catalysis University of Tokyo 2006 39 Kanai, Motomu; Matsunaga, Shigeki Shintani, Ryo Chiral Diene Ligands for Asymmetric Catalysis Kyoto University 2009 42 Hayashi, Tamio Sibi, Mukund P. Are Two Phenyls Better than One? Synthesis and Applications of North Dakota State University 1999 32 (R)-4-Diphenylmethyl-2-oxazolidinone Silvester, Michael J. Fluoroheterocyclic Compounds: Synthesis, Reactions, and Commercial Aldrich Chemical Co., Ltd. (England) 1991 24 Applications Silvester, Michael J. Polyfluorinated Alkenes, Alkynes, and Allenes Sigma-Aldrich Chemical Co., Ltd. 1995 28 Sjoeberg, Kjell PTC in PracTiCe Royal Institute of Technology 1980 13 Smith, Ian C.P. Deuterium NMR—A Useful Technique in Chemistry, Physics, and Biology National Research Council of Canada 1977 10 Snyder, Scott A. Halonium-Induced Cyclization Reactions Columbia University 2011 44 Treitler, Daniel S.; Brucks, Alexandria P. Soderquist, John A. Samarium(II) Iodide in Organic Synthesis University of Puerto Rico 1991 24 Srebnik, Morris The Utility of Chiral Organoboranes in the Preparation of Optically Active Aldrich Chemical Co., Inc. and 1987 20 Ramachandran, P. Veeraraghavan Compounds Purdue University

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To Search, press CTRL+F 33 AUTHORS Title Affiliation Year Vol. Wencel, Joanna Chiral, Chelating, Hydroxyalkyl and Hydroxyaryl N-Heterocyclic Carbenes: Université Européenne de Bretagne 2009 42 Mauduit, Marc; Hénon, Hélène; Kehrli, Design, Synthesis, and Application in Copper-Catalyzed Asymmetric Conjugate and Université de Genève Stefan; Alexakis, Alexandre Addition (Cu-ACA) West, Robert Squaric Acid and the Aromatic Oxocarbons University of Wisconsin at Madison 1968 1 Whalen, Lisa J. Enzymes in Organic Synthesis: Aldolase-Mediated Synthesis of Iminocyclitols The Scripps Research Institute 2006 39 Wong, Chi-Huey and Novel Heterocycles Whitesides, George M. Enzymes as Catalysts in Organic Synthesis Harvard University 1983 16 Wong, C.-H. Wiersum, U.E. Isobenzofuran and Related o-Quinonoid Systems—A New Group of Synthetic Akzo Research Labs, The Netherlands 1981 14 Intermediates Wiersum, U.E. Preparative Flash-Vacuum Thermolysis. The Revival of Pyrolytic Synthesis Akzo Research Labs, The Netherlands 1984 17 Wieting, Joshua M.; Hardman-Baldwin, Silanediol Recognition in Catalysis, Sensing, and Drug Discovery The Ohio State University 2016 49 Andrea M.; Visco, Michael D.; Mattson, Anita E. Williams, Dudley H. Ralph Alexander Raphael: A Lover of Acetylenes at 65 Cambridge University 1986 19 Williams, Dudley H. The Molecular Basis of Biological Order University of Cambridge 1991 24 Williams, Dudley H. The Molecular Basis of Biological Order and Amide-Amide Hydrogen Bonds-An University of Cambridge 1992 25 Addendum Williams, Robert M. Asymmetric Syntheses of α-Amino Acids Colorado State University 1992 25 Winter, Charles H. The Chemical Vapor Deposition of Metal Nitride Films Using Modern Metalorganic Wayne State University 2000 33 Precursors Wiswesser, W.J. Chemical Information Management for the 21st Century Fort Detrick 1973 6 Wiswesser, William J. Johann Josef Loschmidt (1821-1895): A Forgotten Genius. Benzene Rings and Weed Science Research Lab (USDA) 1989 22 Much More in 1861 Wu, Peng Catalytic Azide-Alkyne Cycloaddition: Reactivity and Applications Scripps Research Institute 2007 40 Fokin, Valery V. Xie, Jian-Hua Development of Solvent Selection Guides University of Strathclyde, Glasgow, 2015 48 Zhou, Qi-Lin U.K. Yamamoto, Yoshinori Allylic Tin Compounds in Organic Synthesis Tohoku University 1987 20 Yau, Eric K. Filtering-Column Chromatography—A Fast, Convenient Chromatographic Method University of Michigan 1988 21 Coward, James K. Yoo, Woo-Jin The A3-Coupling (Aldehyde–Alkyne–Amine) Reaction: A Versatile Method for the McGill University 2011 44 Zhao, Liang; Li, Chao-Jun Preparation of Propargylamines Yumei, Xiao; Guo, Hongchao; Kwon, Ohyun Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric China Agricultural University and The 2016 49 Kwon Annulations University of California, Los Angeles Zhao, Hua Applications of Ionic Liquids in Organic Synthesis New Jersey Institute of Technology 2002 35 Malhotra, Sanjay V.

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To Search, press CTRL+F 36 TITLE Authors Affiliation Year Vol. Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building Blocks for Tomalia, Donald A. Dendritic NanoTechnologies, Inc., 2004 37 Nanoscale Synthetic Organic Chemistry Central Michigan University Borane-Amine Complexes for Hydroboration Kanth, Josyula V. B. Aldrich Chemical Co., Inc. 2002 35 Boranes for Organic Reductions—A Forty-Year Odyssey Brown, Herbert C.; Krishnamurthy, S. Purdue University 1979 12 Boron-Based Reducing Agents for the Asymmetric Reduction of Functionalized Ketones and Cho, Byung Tae Hallym University (Korea) 2002 35 Ketimines Boronic Acid Catalysis: an Atom-Economical Platform for Direct Activation and Hall, Dennis G.; Zheng, Hongchao University of Alberta 2014 47 Functionalization of Carboxylic Acids and Alcohols Bromotrimethylsilane and Iodotrimethylsilane—Versatile Reagents for Organic Synthesis Schmidt, Arthur H. Fachhochschule Fresenius 1981 14 Building Blocks for Dendritic Macromolecules Newkome, George R.; Moorefield, University of South Florida 1992 25 Charles N.; Baker, Gregory R. Calixarenes Gutsche, C. David Texas Christian U. 1995 28 Carbocation and Onium Ion Reagents Olah, George A. Case Western Reserve University 1973 6 Carbon–Carbon π Bonds as Conjunctive Reagents in Cross-Coupling Engle, Keary M. The Scripps Research Institute 2018 51 Derosa, Joseph; Tran, Van T.; van der Puyl, Vincent A. Carboxyolefination Kulkarni, Yashwant S. Aldrich Chemical Co., Inc. 1990 23 Catalytic Asymmetric Hydrogenation of α-Substituted Ketones and Aldehydes via Dynamic Xie, Jian-Hua; Zhou, Qi-Lin Nankai University, Tianjin, China 2015 48 Kinetic Resolution: Efficient Approach to Chiral Alcohols Catalytic Azide-Alkyne Cycloaddition: Reactivity and Applications Wu, Peng; Fokin, Valery V. 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(Units of Monsanto) Chiral Starting Materials and Reagents—An Outline of Recent Synthetic Applications Szabo, William A.; Lee, H.T. Aldrich Chemical Co., Inc. 1980 13 Chiral, Chelating, Hydroxyalkyl and Hydroxyaryl N-Heterocyclic Carbenes: Design, Wencel, Joanna; Mauduit, Marc; Université Européenne de 2009 42 Synthesis, and Application in Copper-Catalyzed Asymmetric Conjugate Addition (Cu-ACA) Hénon, Hélène; Kehrli, Stefan; Bretagne and Université de Alexakis, Alexandre Genève To Search, press CTRL+F 37 TITLE Authors Affiliation Year Vol. Chiral, Poly(Rare-Earth-Metal) Complexes in Asymmetric Catalysis Shibasaki, Masakatsu; Kanai, University of Tokyo 2006 39 Motomu; Matsunaga, Shigeki Chlorosulfonyl Isocyanate: Silver Anniversary of a Lively Heterocumulene Szabo, William A. Aldrich Chemical Co., Inc. 1977 10 Choosing and Using Noble Metal Hydrogenation Catalysts Rylander, Paul N. Engelhard Minerals and Chemicals 1979 12 Corp. CLAYCOP, a User-Friendly Oxidizing and Nitrating Reagent Laszlo, Pierre; Cornelis, Andre Universite de Liege 1988 21 Computer Aids Search for R&D Chemicals Anonymous C&EN 1968, 46 (Sept. 2), 26-27; 1969 2 (Reprinted from) Continuous-Flow Macrocyclization Collins, Shawn K. Université de Montréal 2018 51 Godin, Éric; Morin, Émilie Copper-, Silver-, and Gold-Catalyzed Migratory Cycloisomerizations Leading to Heterocyclic Dudnik, Alexander S.; Chernyak, University of Illinois at Chicago 2010 43 Five-Membered Rings Natalia; Gevorgyan, Vladimir Copper-Free Click Chemistry: Bioorthogonal Reagents for Tagging Azides Baskin, Jeremy M.; Bertozzi, University of California, Berkeley 2010 43 Carolyn R. Cornelis Bega’s Alchemist: A Problem in Art History Bader, Alfred R. 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To Search, press CTRL+F 38 TITLE Authors Affiliation Year Vol. Development of Solvent Selection Guides Watson, Allan J. B.; Eastman, Harry University of Strathclyde, 2015 48 E.; Jamieson, Craig Glasgow, U.K. Diisopinocampheylchloroborane, (DIP-Chloride), an Excellent Chiral Reducing Reagent for Dhar, Raj K. Aldrich Chemical Co., Inc. 1994 27 the Synthesis of Secondary Alcohols of High Enantiomeric Purity Dimethyl Tricylclo[4.2.1.02,5]nona-3,7-diene-3,4-dicarboxylate: A Versatile Ambident Warrener, Ronald N.; Butler, Central Queensland University 1997 30 Dienophile Douglas N. Discovering New Reactions with N-Heterocyclic Carbene Catalysis Phillips, Eric M.; Chan, Audrey; Northwestern University 2009 42 Scheidt, Karl A. Disproportionate Impact of Named Reactions on Chemical Biology Chan, Jefferson, University of Illinois at Urbana- 2017 50 Bearrood, Thomas E. Champaign Dry-Column Flash Chromatography Harwood, Lawrence M. Oxford University 1985 18 Dutch Art and the Aldrich Collection Clark, Anthony M. Aldrich Chemical Co., Inc. 1968 1 Electrochemistry in Organic Synthesis Fry, Albert J. Wesleyan University 1993 26 Enabling Novel Photoredox Reactivity via Photocatalyst Selection Stephenson, Corey R. J., Douglas, University of Michigan; Lilly 2014 47 James J., Nguyen, John D., Cole, Research Laboratories Kevin P. Enantiopure Sulfoxides and Sulfinamides: Recent Developments in Their Stereoselective Senanayake, Chris H.; Boehringer Ingelheim 2005 38 Synthesis and Applications to Asymmetric Synthesis Krishnamurthy, Dhileepkumar; Lu, Pharmaceuticals, Inc. Zhi-Hui; Han, Zhengxu; Gallou, Isabelle Enantioselective Synthesis Based on Catalysis by Chiral Oxazaborolidinium Cations Mukherjee, Santanu; Corey, E. J. Harvard University 2010 43 Enantioselective Synthesis of β-Amino Acids Juaristi, Eusebio; Quintana, Delia; Instituto Politecnico Nacional 1994 27 Escalante, Jaime (Mexico) Enzymatic Dihydroxylation of Aromatics in Enantioselective Synthesis: Expanding Hudlicky, Tomas; Gonzalez, David; University of Florida, Gainsville; 1999 32 Asymmetric Methodology Gibson, David T. University of Iowa, Iowa City Enzymes as Catalysts in Organic Synthesis Whitesides, George M.; Wong, C.-H. Harvard University 1983 16 Enzymes in Organic Synthesis: Aldolase-Mediated Synthesis of Iminocyclitols and Novel Whalen, Lisa J.; Wong, Chi-Huey The Scripps Research Institute 2006 39 Heterocycles Esterifications, Transesterifications, and Deesterifications Mediated by Organotin Oxides, Mascaretti, Oreste A.; Furlan, CONICET-UNR 1997 30 Hydroxides, and Alkoxides Ricardo L.E. Evolution and Applications of Second-Generation Ruthenium Olefin Metathesis Catalysts Schrodi, Yann; Pederson, Richard L. Materia, Inc. 2007 40 Filtering-Column Chromatography—A Fast, Convenient Chromatographic Method Yau, Eric K.; Coward, James K. University of Michigan 1988 21 Fluoroaromatic Compounds: Synthesis, Reactions and Commercial Applications Hewitt, Christopher D.; Silvester, Aldrich Chemical Co., Inc. 1988 21 Michael J. Fluoroenolate-Enabled Monofluorinations and Difluoromethylations Colby, David A. University of Mississippi 2018 51 Sowaileh, Munia F. Fluoroheterocyclic Compounds: Synthesis, Reactions, and Commercial Applications Silvester, Michael J. Aldrich Chemical Co., Ltd. 1991 24 (England) Fluorous Chemistry Meets Green Chemistry: A Concise Primer Gladysz, John A.; Mukherjee, Department of Chemistry, Texas 2015 48 Tathagata A&M University Formamidines as Precursors to α-Amino Carbanions and their Application to Asymmetric Meyers, Albert I. Colorado State University 1985 18 C-C Bond-Forming Reactions Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation: Patman, Ryan L.; Bower, John F.; University of Texas at Austin 2008 41 Vinylation, Allylation and Enolate Addition Kim, In Su; Krische, Michael J. To Search, press CTRL+F 39 TITLE Authors Affiliation Year Vol. 3-Formylchromone as a Versatile Synthon in Heterocyclic Chemistry Sabitha, Gowravaram Indian Institute of Chemical 1996 29 Technology Fragment Information Retrieval of Structures Buth, William F. Aldrich Chemical Co., Inc. 1968 1 Gilbert Stork: A Celebration of 35 Years in Research & Teaching Hoffman, Frances Columbia University 1982 15 Gold-Catalysed Addition of X-H Bonds to C-C Multiple Bonds Hashmi, A. Stephen K.; Bührle, Ruprecht-Karls-Universität 2010 43 Miriam Heidelberg Green Chemistry in the Introductory Organic Laboratory Lipshutz, Bruce H.; Ghoraib, Subir Department of Chemistry & 2015 48 Biochemistry, University of California, Santa Barbara; Chemistry New Product Research & Development, Sigma-Aldrich Corp. Green Chemistry Next: Moving from Evolutionary to Revolutionary Anastas, Paul T. Center for Green Chemistry and 2015 48 Green Engineering, Yale University Greener and Sustainable Applications of Phosphorus and Sulfur Ylides Perosa, Alvise Università Ca’ Foscari, Venezia 2018 51 Cattelan, Lisa; Fiorani, Giulia; (Italy) Selva, Maurizio Guidelines for Handling Air-Sensitive Compounds Gill, G. B.; Whiting, D.A. University of Nottingham 1986 19 Halonium-Induced Cyclization Reactions Snyder, Scott A.; Treitler, Daniel S.; Columbia University 2011 44 Brucks, Alexandria P. Handling Air-Sensitive Reagents Lane, Clinton F.; Kramer, Gary W. Aldrich-Boranes, Inc. and 1977 10 Purdue U. Herbert C. Brown and Aldrich Firsan, Sharbil J. Aldrich Chemical Co., Inc. 2002 35 Herbert C. Brown and Aldrich: Advancing Borane Chemistry for 32 Years Lane, Clinton F. Northern Arizona University 2005 38 Hexachlorocyclopentadiene Adducts of Aromatic Compounds and their Reaction Products Look, Melvin Hyman Laboratories, Inc. 1974 7 Highlights Harvey, David R. Aldrich Chemical Co., Inc. 1975 8 Highlights from Two Decades of Synthetic Radical Chemistry Curran, Dennis P. University of Pittsburgh 2000 33 Highlights of the Chemistry of Enantiomerically Pure Aziridine-2-carboxylates Lee, Won Koo; Ha, Hyun-Joon Sogang University; Hankuk 2003 36 University of Foreign Studies (Korea) Highly Enantioselective Hydroformylation of Alkenes by Rhodium-Diazaphospholane Landis, Clark R.; Wong, Gene W. University of Wisconsin at Madison 2014 47 Catalysts How to Find a Great Herbicide Bader, Alfred R. Aldrich Chemical Co., Ltd. 1988 21 (England) How We Stumbled into Peptide Chemistry Seebach, Dieter Eidgenoessischen Technischen 1992 25 Hochschule Hydrazine—Rocket Fuel to Synthetic Tool Schiessl, Henry W. Olin Corporation 1980 13 Hydroalumination Reactions in Organic Chemistry Roesky, Herbert W. The University of Goettingen 2004 37 Hydroxylamine-O-sulfonic Acid—A Versatile Synthetic Reagent Wallace, Raymond G. Brunel University 1980 13 [Hydroxy(tosyloxy)iodo]benzene and Closely Related Iodanes: The Second Stage of Koser, Gerald F. The University of Akron 2001 34 Development Improving Nature’s Catalysts Epton, R.; Thomas, T.H. Koch-Light Laboratories, Ltd. 1971 4

To Search, press CTRL+F 40 TITLE Authors Affiliation Year Vol. Iodobenzene Diacetate and Related Hypervalent Iodine Reagents in the Synthesis of Prakash, Om; Singh, Shiv P. Kurukshetra University 1994 27 Heterocyclic Compounds 2-Iodoxybenzenesulfonic Acid (IBS) Catalyzed Uyanik, Muhammet; Nagoya University (Japan) 2010 43 Ishihara, Kazuaki

5 + Iron Lewis Acid [(η -C5H5)Fe(CO)2(THF)] Catalyzed Organic Reactions Redlich, Mark D.; Mayer, Michael F.; University of Wisconsin-Milwaukee 2003 36 Hossain, M. Mahmun Isobenzofuran and Related o-Quinonoid Systems—A New Group of Synthetic Intermediates Wiersum, U.E. Akzo Research Labs, The 1981 14 Netherlands Isonitriles Ferosie, Ishak Aldrich Chemical Co., Inc. 1971 4 Iterative Cross-Coupling with MIDA Boronates: towards a General Strategy for Small- Gillis, Eric P.; Burke, Martin D. University of Illinois at Urbana- 2009 42 Molecule Synthesis Champaign Johann Josef Loschmidt (1821-1895): A Forgotten Genius. Benzene Rings and Much More in Wiswesser, William J. Weed Science Research Lab 1989 22 1861 (USDA) John D. Roberts Dervan, Peter B. California Institute of Technology 1988 21 Lanthanide Chemical Shift Reagents Campbell, John R. Aldrich Chemical Co., Inc. 1971 4 Lanthanides in Organic Synthesis Long, John R. 1985 18 Lectins Balding, Peter; Humphryes, Ken C. Sigma-London 1983 16 Liquid Crystals and Modern Art Bader, Alfred R. Aldrich Chemical Co., Inc. 1970 3 Liquid Crystals and Science Fergason, James L. Kent State University 1970 3 Long-Range Electron Transfer in Proteins Gray, Harry B. California Institute of Technology 1990 23 Macrocyclic Polyethers for Complexing Metals Pedersen, Charles J. E.I. Du Pont de Nemours & Co., 1971 4 Inc. Manganese-Based Organic and Bioinorganic Transformations Melikyan, Gagik G. California State University, 1998 31 Northridge Mechanistic Ingenuity in Enzyme Catalysis: Dehydroquinate Synthase Knowles, Jeremy R. Harvard University 1989 22 Metal-Catalyzed, Highly Selective Oxygenations of Olefins and Acetylenes with tert-Butyl Sharpless, K. Barry; Verhoeven, Stanford University 1979 12 Hydroperoxide. Practical Considerations and Mechanisms. Thomas R. Mismatches and Mutagenic Lesions in Nucleic Acids Brown, Tom University of Southampton 1995 28 Modern Methods for the Monofluorination of Aliphatic Organic Compounds. Nucleophilic Mascaretti, Oreste A. CONICET-Universidad Nacional de 1993 26 Fluoride Transfer Agents Rosario Modern Strategies in Organic Catalysis: The Advent and Development of Iminium Activation Lelais, Gerald; MacMillan, David W. C. California Institute of Technology 2006 39 Moving Toward a Green Chemistry and Engineering Design Ethic Constable, David J. C. Green Chemistry Institute, 2015 48 American Chemical Society New Developments in Chemiluminescence Research Gill, Steven K. Liquid Light Laboratories 1983 16 New Methods in the Formation of Macrocyclic Lactams and Lactones of Biological Interest Wasserman, Harry H. Yale University 1987 20 New Possibilities in Organic Synthesis Mukaiyama, Teruaki Science University of Tokyo 1996 29 New Reactions for Forming Heterocycles and Their Use in Natural Products Synthesis Overman, Larry E. University of California at Irvine 1995 28 New Reagents for Hydroboration and for Synthesis via Boranes Brown, Herbert C. Purdue University 1974 7 New Synthetic Methods and Strategies and Total Synthesis of Natural Products Nicolaou, K.C. University of California at San 1993 26 Diego

To Search, press CTRL+F 41 TITLE Authors Affiliation Year Vol. New Synthetic Reagents and Reactions Olah, George A. University of Southern California 1979 12 at Los Angeles New Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Easy Routes to Behrens, Carl H.; Sharpless, K. Barry Massachusetts Institute of 1983 16 Homochiral Substances Technology N-Heterocyclic Carbene—Copper Complexes: Synthesis and Applications in Catalysis Díez-González, Silvia; Nolan, Institute of Chemical Research of 2008 41 Steven P. Catalonia (ICIQ) Nonnatural Products Nonpareil Hormann, Robert E. Rohm and Haas Co. 1996 29 Novel Methods of Resolving Racemic Diols and Amino Alcohols Periasamy, Mariappan University of Hyderabad 2002 35 Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations Yumei, Xiao; Guo, Hongchao; Kwon, China Agricultural University and 2016 49 Ohyun Kwon The University of California, Los Angeles O-Acyl Thiohydroxamates: New and Versatile Sources of Alkyl Radicals for Use in Organic Crich, David University College London 1987 20 Synthesis Of Things to Come Bader, Alfred R. Aldrich Chemical Co., Inc. 1968 1 On Opinion in Good Men: An Oblique Tribute to H.C. Brown Davenport, Derek A. Purdue University 1987 20 Opening New Chemical Space through Novel Dearomatization Reactions Harrison, Daniel P.; Harman, W. Dean University of Virginia 2012 45 Organic Chemistry in Unconventional Solvents Grieco, Paul A. Indiana University 1991 24 Organic Sulfur Compounds in Organic Synthesis: Some Recent Advances Block, Eric University of Missouri at St. Louis 1978 11 Organic Synthesis and Device Testing for Molecular Electronics James, Dustin K.; Tour, James M. Rice University 2006 39 Organic Synthesis via Organoboranes: II. Selective Reductions Using Borane- Lane, Clinton F. Aldrich-Boranes, Inc. 1974 7 Tetrahydrofuran Complex Organic Synthesis via Organoboranes: III. Ester Reductions with Super-Hydride Lane, Clinton F. Aldrich-Boranes, Inc. 1974 7 Organic Synthesis via Organoboranes: IV. Reduction of Organic Functional Groups with Lane, Clinton F. Aldrich-Boranes, Inc. 1975 8 Borane-Methyl Sulfide Organic Synthesis with Light-Fluorous Reagents, Reactants, Catalysts, and Scavengers Curran, Dennis P. University of Pittsburgh 2006 39 Organo Iodine(III) and Thallium(III) Reagents in Organic Synthesis: Useful Methodologies Prakash, Om Kurukshetra University 1995 28 Based on Oxidative Rearrangements Organoboranes in Organic Synthesis Kabalka, George W. University of Tenessee at Knoxville 1975 8 Organofluorine Chemistry: Deoxyfluorination Reagents for C-F Bond Synthesis Al-Maharik, Nawaf; O’Hagan, David University of St. Andrews 2011 44 Organosilicon Reagents for Carbon-Carbon Bond-Forming Reactions Magnus, Philip Ohio State University 1980 13 Organosilicon Reagents: Synthesis and Application to Palladium-Catalyzed Cross-Coupling Denmark, Scott E.; Ober, Michael H. University of Illinois at Urbana- 2003 36 Reactions Champaign Organothallium Chemistry—New Horizons in Synthesis Taylor, Edward C.; McKillop, Princeton University & U. of East 1970 3 Alexander Anglia Organotrifluoroborates: Expanding Organoboron Chemistry Molander, Gary A.; Figueroa, Ruth The University of Pennsylvania 2005 38 Organozirconium Compounds as New Reagents and Intermediates Negishi, Ei-ichi; Takahashi, Tamotsu Purdue University 1985 18 Our Chemist-Collector Approaches Sixty Cori, Tom; Emanuel, Ralph N.; Sigma-Aldrich Corp., M. Emanuel, 1984 17 Harvey, David; Klitsner, Marvin E. Ltd., Aldrich Chemical Co., and Foley & Lardner Oxalyl Chloride in Photochemical Chlorocarbonylation of Cage Compounds Bashir-Hashemi, A.; Doyle, Gerald GEO-Centers, Inc. at ARDEC 1996 29 Oxidation Reactions Using Magnesium Monoperphthalate and Urea Hydrogen Peroxide Heaney, Harry Loughborough U. of Technology 1993 26

To Search, press CTRL+F 42 TITLE Authors Affiliation Year Vol. Palladium-Catalyzed Alkenylation by the Negishi Coupling Negishi, Ei-ichi; Hu, Qian; Huang, Purdue University 2005 38 Zhihong; Qian, Mingxing; Wang, Guangwei Palladium-Catalyzed Dynamic Kinetic Asymmetric Allylic Alkylation with the DPPBA Ligands Trost, Barry M.; Fandrick, Daniel R. Stanford University 2007 40 Palladium-Catalyzed meta- and para-C–H Bond Functionalizations Assisted by a Directing Li, Gang, Fujian Institute of Research on the 2017 50 Group Gao, Yuzhen Structure of Matter Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters Fukuyama, Tohru; Tokuyama, The University of Tokyo 2004 37 Hidetoshi Pd-N-Heterocyclic Carbene (NHC) Catalysts for Cross-Coupling Reactions Kantchev, Eric Assen B.; O’Brien, York University (Toronto, ON, 2006 39 Christopher J.; Organ, Michael G. Canada) Permeation Chromatography of Organic Solutes Using Enzacryl Gel Packings Epton, Roger Koch-Light Laboratories, Ltd. 1976 9 Peroxide-Mediated Wacker Oxidations for Organic Synthesis Michel, Brian W.; Sigman, University of Utah 2011 44 Matthew W. Pharmaceutical Green Chemistry at Amgen: Seeing with New Eyes Tucker, John L. Process Development, Amgen Inc. 2015 48 Phenothiazines, Dihydrophenazines, and Phenoxazines: Sustainable Alternatives to Miyake, Garret M. Colorado State University 2019 52 Precious-Metal-Based Photoredox Catalysts Corbin, Daniel A.; Lim, Chern-Hooi Photocatalytic C–F Reduction and Functionalization Senaweera, Sameera Oklahoma State University 2016 49 Weaver, Jimmie D. Pinane-Based Versatile Allylboranes Ramachandran, P. Veeraraghavan Purdue University 2002 35 Please Call Me Alfred (Editorial) Firsan, Sharbil J. Sigma-Aldrich Corp. (Milwaukee) 2009 42 Polycyclic Cage Compounds: Reagents, Substrates, and Materials for the 21st Century Marchand, Alan P. University of North Texas 1995 28 Polyfluorinated Alkenes, Alkynes, and Allenes Silvester, Michael J. Sigma-Aldrich Chemical Co., Ltd. 1995 28 Polymeric Dyes Dawson, D.J. Dynapol 1981 14 Polymeric Reagents Crosby, Guy A. Dynapol 1976 9 Polymer-Incarcerated Metals: Highly Reactive, Recoverable, and Multifunctional Nanocluster Kobayashi, Shū; Miyamura, Hiroyuki University of Tokyo 2013 46 Catalysts for Organic Synthesis Polyurea-Encapsulated Palladium Catalysts: The Development and Application of a New and Pears, David A.; Smith, Stephen C. Avecia Pharmaceuticals and 2005 38 Versatile Immobilized-Homogeneous- Catalyst Technology Syngenta Powerful and Versatile Silicon Lewis Acids for Asymmetric Chemical Synthesis Leighton, James L. Columbia University 2010 43

Practical Aerobic Alcohol Oxidation with Cu/Nitroxyl and Nitroxyl/NOx Catalyst Systems Stahl, Shannon S.; Miles, Kelsey C. Department of Chemistry, 2015 48 University of Wisconsin-Madison Practical Organocatalysis with (S)- and (R)-5-Pyrrolidin-2-yl- 1H-tetrazoles Longbottom, Deborah A.; University of Cambridge (U.K.) 2008 41 Franckevicius, Vilius; Kumarn, Sirirat; Oelke, Alexander J.; Wascholowski, Veit; Ley, Steven V. Prague Revisited Bader, Alfred R. Aldrich Chemical Co., Inc. 1969 2 Preparation and Reactions of Diazomethane Hopps, Harvey B. Aldrich Chemical Co., Inc. 1970 3 Preparation and Reactivity of Acyclic (Pentadienyl)iron(1+) Cations: Applications to Organic Donaldson, William A. Marquette University 1997 30 Synthesis Preparation of Chiral Diamines by the Diaza-Cope Rearrangement (DCR) Kim, Hyunwoo; So, Soon Mog; University of Toronto and Seoul 2008 41 Chin, Jik; Kim, B. Moon National University

To Search, press CTRL+F 43 TITLE Authors Affiliation Year Vol. Preparative Flash-Vacuum Thermolysis. The Revival of Pyrolytic Synthesis Wiersum, U.E. Akzo Research Labs- The 1984 17 Netherlands Probing the Specificity of Synthetically Useful Enzymes Jones, J. Bryan University of Toronto 1993 26 PTC in PracTiCe Sjoeberg, Kjell Royal Institute of Technology 1980 13 Purpald®: A Reagent That Turns Aldehydes Purple! Hopps, Harvey B. Amarillo College 2000 33 Ralph Alexander Raphael: A Lover of Acetylenes at 65 Williams, Dudley H. Cambridge University 1986 19 Rare Earth Triflates in Organic Synthesis Marshman, Robert W. Aldrich Chemical Co., Inc. 1995 28 Reactive Chemical Hazard Evaluation in the Scale-Up of Chemical Processes Amery, Gordon Sigma-Aldrich Company Ltd. 2001 34 (Gillingham) Recent Advances in Alkene Metathesis for Natural Product Synthesis—Striking Achievements Vanderwal, Christopher D. University of California, Irvine 2017 50 Resulting from Increased Sophistication in Catalyst Design and Synthesis Strategy Atwood, Brian R. Recent Advances in Intermolecular Direct Arylation Reactions Campeau, Louis-Charles; Stuart, University of Ottawa (Canada) 2007 40 David R.; Fagnou, Keith Recent Advances in Microwave-Assisted Synthesis Hayes, Brittany L. CEM Corporation 2004 37 Recent Advances in Synthetic Pyrethroids Bader, Alfred R. Aldrich Chemical Co., Inc. 1976 9 Recent Advances in the Application of α-Phenylethylamine (α-PEA) in the Preparation of Bandala, Yamir; Juaristi, Eusebio Instituto Politécnico Nacional 2010 43 Enantiopure Compounds (México) Recent Advances in the Asymmetric Catalytic Mannich Reaction Greco, Sandro José; Lacerda, Universidade Federal do Espírito 2011 44 Valdemar, Jr.; dos Santos, Santo (Brasil) Reginaldo Bezerra Recent Advances in the Buchwald–Hartwig Amination Reaction Enabled by the Application of Lundgren, Rylan J.; Stradiotto, Mark Dalhousie University 2012 45 Sterically Demanding Phosphine Ancillary Ligands Recent Advances in the Chemistry of Allenes Ma, Shengming Shanghai Institute of Organic 2007 40 Chemistry Recent Advances in the Chemistry of Lithium Aminoborohydrides Pasumansky, Lubov; Singaram, University of California, Santa 2005 38 Bakthan; Goralski, Christian T. Cruz Recent Advances in the Prins Cyclization Greco, Sandro José Greco; Fiorot, Federal University of Espírito 2013 46 Rodolfo Goetze; Lacerda, Jr., Santo Valdemar; dos Santos, Reginaldo Bezerra Recent Applications of Homogeneous Catalysis to Organic Synthesis Black, T. Howard Aldrich Chemical Co., Inc. 1982 15 Recent Applications of Proazaphosphatranes in Organic Synthesis Verkade, John G.; Kisanga, Philip B. Iowa State University and Albany 2004 37 Molecular Research, Inc. Recent Developments in the Chemistry of Natural Products Kishi, Yoshito Harvard University 1980 13 Recent Enabling Technologies for Diazomethane Generation and Reactions Dallinger, Doris University of Graz and 2016 49 Kappe, C. Oliver the Research Center for Pharmaceutical Engineering Recent Methods for the Synthesis of Conjugated Lactones Newaz, S.S. Aldrich Chemical Co., Inc. 1977 10 Recent Progress in Macrolide Synthesis Masamune, Satoru University of Alberta 1978 11 Reflections on Organic Synthesis: The Evolution of a General Strategy for the Danishefsky, Samuel J. Yale University 1986 19 Stereoselective Construction of Polyoxygenated Natural Products Remembering Dr. Alfred R. Bader (1924–2018) Firsan, Sharbil J. Merck KGaA, Darmstadt, Germany 2019 52 Remembering Dr. Jai P. Nagarkatti (1947–2010) Firsan, Sharbil J. Sigma-Aldrich Corp. 2010 43 To Search, press CTRL+F 44 TITLE Authors Affiliation Year Vol. Ring-Closing Metathesis of Nitrogen-Containing Compounds: Applications to Heterocycles, Phillips, Andrew J.; Abell, Andrew D. University of Canterbury, New 1999 32 Alkaloids, and Peptidomimetics Zealand Robert Burns Woodward: Three Score Years and Then? Dolphin, David University of British Columbia 1977 10 ROM Polymerization in Facilitated Synthesis Harned, Andrew M.; Zhang, Mianji; The University of Kansas 2005 38 Vedantham, Punitha; Mukherjee, Shubhasish; Herpel, Russell H.; Flynn, Daniel L.; Hanson, Paul R. Ruthenium-Catalyzed anti-Markovnikov Hydration and Reductive Hydration of Herzon, Seth B.; Zeng, Mingshuo Yale University 2014 47 Terminal Alkynes Samarium(II) Iodide in Organic Synthesis Soderquist, John A. University of Puerto Rico 1991 24 Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Schmink, Jason R.; Bellomo, Ana; Bryn Mawr College, University of 2013 46 Industry Berritt, Simon Pennsylvania Selecting and Driving Monolayer Structures through Tailored Intermolecular Interactions Mullen, Thomas J.; Dameron, Pennsylvania State University 2007 40 Arrelaine A.; Andrews, Anne M.; Weiss, Paul S. Selective Reduction of the Carbonyl Group in α,β-Unsaturated Aldehydes and Ketones Lane, Clinton F. Aldrich-Boranes, Inc. 1976 9 Selective Reductions Using Borane Complexes Lane, Clinton F. Aldrich-Boranes, Inc. 1977 10 Selenium Reagents for Organic Synthesis Clive, Derrick L. J. University of Alberta 1978 11 Serine Derivatives in Organic Synthesis Kulkarni, Yashwant S. Aldrich Chemical Co., Inc. 1999 32 Silanediol Recognition in Catalysis, Sensing, and Drug Discovery Wieting, Joshua M.; Hardman- The Ohio State University 2016 49 Baldwin, Andrea M.; Visco, Michael D.; Mattson, Anita E. Simple, Novel Methods for the Synthesis of Carbonyl Compounds Using Metal Complexes as Alper, Howard University of Ottawa 1991 24 Catalysts SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of Bode, Jeffrey W.; Luescher, ETH-Zürich (Laboratorium für 2015 48 Saturated N-Heterocycles Michael U.; Geoghegan, Kimberly; Organische Chemie) Nichols, Paula L. Sodium Cyanoborohydride: A Highly Selective Reducing Agent Lane, Clinton F. Aldrich-Boranes, Inc. 1975 8 Solid-Phase Dendrimer Chemistry: Synthesis and Applications Lebreton, S.; Monaghan, S.; University of Southampton 2001 34 Bradley, M. Some Useful Synthetic Applications of Gold’s Reagent Gupton, John T. University of Central Florida 1986 19 Special Reagents for Thiol Groups Anonymous Aldrich Chemical Co., Inc. 1971 4 Spin Trapping Evans, C. Anderson Varian Associates 1979 12 Spontaneous Polymerizations Can Occur During Cycloaddition Reactions of Olefins and Hall, H.K., Jr.; Padias, Buyle University of Arizona 1995 28 Dienes Squaric Acid and the Aromatic Oxocarbons West, Robert University of Wisconsin at Madison 1968 1 Starburst/Cascade Dendrimers: Fundamental Building Blocks for a New Nanoscopic Tomalia, Donald A. Michigan Molecular Institute 1993 26 Chemistry Set Steroidal Saponin Esters Elaborated by Poisonous Marine Echinoderms Friess, S. L. Naval Medical Research Institute 1970 3 Studies in Asymmetric Synthesis. The Development of Practical Chiral Enolate Synthons Evans, David A. California Institute of Technology 1982 15 4-Substituted Prolines: Useful Reagents in Enantioselective Synthesis and Conformational Tolomelli, Alessandra “G. Ciamician” University of 2017 50 Restraints in the Design of Bioactive Peptidomimetics Ferrazzano, Lucia; Amoroso, Rosa Bologna

To Search, press CTRL+F 45 TITLE Authors Affiliation Year Vol. Switchable Solvents as Media for Synthesis and Separations Jessop, Philip G. Department of Chemistry, Queen’s 2015 48 University, Kingston, Ontario, Canada Synthesis and Applications of Diorganozinc Reagents: Beyond Diethylzinc Lemire, Alexandre; Côté, Alexandre; Université de Montréal 2009 42 Janes, Marc K.; Charette, André B. Synthesis and Applications of Vinylic Organoboranes Brown, Herbert C.; Campbell, Purdue University 1981 14 James B., Jr. Synthesis of Benzocyclobutene and Derivatives Klundt, Irwin L. Aldrich Chemical Co., Inc. 1970 3 Synthesis of Biologically Important Oligosaccharides and Other Glycoconjugates by the Seeberger, P.H.; Bilodeau, M.T.; Sloan-Kettering Institute for 1997 30 Glycal Assembly Method Danishefsky, S.J. Cancer Research Synthetic Applications of Buchwald’s Phosphines in Palladium-Catalyzed Aromatic-Bond- Mauger, Christelle C.; Mignani, Rhodia Recherches et Technologies 2006 39 Forming Reactions Gerard A. Synthetic Applications of Indium Trichloride Catalyzed Reactions Babu, G. Perumal, P. T. Central Leather Research Institute 2000 33 (Chennai, India) Synthetic Applications of Zinc Borohydride Narasimhan, S.; Balakumar, R. Centre for Agrochem. Res. 1998 31 (Guindy, India) Synthetic Aspects of Electron-Transfer Chemistry Kornblum, Nathan Purdue University 1990 23 Synthetic Methodology in the Context of Natural Product Total Synthesis Ireland, Robert E. University of Virginia 1988 21 Synthetic Routes to Cyclopentanoid-Fused Unnatural and Natural Products Paquette, Leo A. Ohio State University 1984 17 Taking a Measure of Green Success Ritter, Stephen K. Chemical & Engineering News, 2015 48 American Chemical Society Tailoring Polystyrene Solid-Phase Synthesis Resins: Incorporation of Flexible Cross-Linkers Toy, Patrick H.; Reger, Thomas S.; The Scripps Research Institute 2000 33 Janda, Kim D. Teaching Organic Synthesis: Why, How, What? Seoane, Carlos Universidad de Castilla-La Mancha 1989 22 TEMPO-Derived Oxoammonium Salts as Versatile Oxidizing Agents Leadbeater, Nicholas E.; University of Connecticut 2014 47 Bobbitt, James M. Tetrathiafulvalenes (TTF) and their Selenium and Tellurium Analogs (TSF and TTeF): Bryce, Martin R. 1985 18 Electron Donors for Organic Metals Thallium Chemistry: A Study in International Cooperation Bader, Alfred R. Aldrich Chemical Co., Inc. 1970 3 The A3-Coupling (Aldehyde–Alkyne–Amine) Reaction: A Versatile Method for the Yoo, Woo-Jin; Zhao, Liang; McGill University 2011 44 Preparation of Propargylamines Li, Chao-Jun The Aldrich First System of Information Retrieval Griffiths, David W. Aldrich Chemical Co., Inc. 1974 7 The Aldrich FIRST System of Information Retrieval—An Update Griffiths, David W. Aldrich Chemical Co., Inc. 1985 18 The Application of Electron Spin Resonance and Spin-Labeling in Biochemistry and Chignell, Colin F. National Heart and Lung Institute 1974 7 Pharmacology The Borane-Amine Complexes Lane, Clinton F. Aldrich-Boranes, Inc. 1973 6 The Catalytic Synthesis of Thiacrowns from Thietanes and Thiiranes by Metal Carbonyl Adams, Richard D. University of South Carolina 2000 33 Complexes The Chemical Synthesis of DNA Crockett, Geoffrey C. Aldrich Chemical Co., Inc. 1983 16 The Chemical Vapor Deposition of Metal Nitride Films Using Modern Metalorganic Precursors Winter, Charles H. Wayne State University 2000 33 The Chiral Auxiliary [(C5H5)Fe(CO)(PPh3)] for Asymmetric Synthesis Davies, Stephen G. Dyson Perrins Laboratory 1990 23 The Compleat Chemists Koppel, Henry Aldrich Chemical Co., Inc. 1968 1 To Search, press CTRL+F 46 TITLE Authors Affiliation Year Vol. The Concept of Strategy in Organic Synthesis Deslongchamps, Pierre Universite de Sherbrooke 1984 17 The Determination of Optical and Enantiomeric Purity by Nuclear Magnetic Resonance Campbell, John Aldrich Chemical Co., Inc. 1972 5 Spectroscopy (NMR) The Direct Synthesis of Non-Transition-Metal Organo Derivatives Massey, A.G.; Humphries, R. E. University of Technology 1989 22 (Loughborough) and U. of New Brunswick (St. John) The Evolution of Totally Synthetic, Strong Analgesics May, Everette L. National Institutes of Health 1969 2 The Growing Impact of Niobium in Organic Synthesis and Catalysis Lacerda, Valdemar, Jr.; Dos Santos, Universidade Federal do Espírito 2012 45 Deborah Araujo; da Silva-Filho, Luiz Santo and Universidade Estadual Carlos; Greco, Sandro José; dos Paulista (Brasil) Santos, Reginaldo Bezerra The Intermediacy of Transition-Metal Silicon-Bonded Complexes: Recent Developments Recatto, Craig A. Aldrich Chemical Co., Inc. 1995 28 The Invention of Chemical Reactions Barton, Derek H. R. Texas A&M University 1990 23 The Ireland-Claisen Rearrangement Pereira, Schubert; Srebnik, Morris University of Toledo 1993 26 The Leading Edge of Green Chemistry at Genentech Koenig, Stefan G.; Bryan, Marian C.; Genentech, Inc. 2015 48 Budzinski, Kristi L. The Mechanisms of Oxygen Transfer from Acyl and Alkyl Hydroperoxides to Metal(III) Bruice, Thomas C. University of California at Santa 1988 21 Porphyrins and the Epoxidation of Alkenes by the Resultant Hypervalent Metal-Oxo Barbara Porphyrin Products The Methadone Story May, Everette L. National Institutes of Health 1972 5 The Molecular Basis of Biological Order Williams, Dudley H. University of Cambridge 1991 24 The Molecular Basis of Biological Order and Amide-Amide Hydrogen Bonds-An Addendum Williams, Dudley H. University of Cambridge 1992 25 The Preparation and Reactions of Diazomethane Black, T. Howard Aldrich Chemical Co., Inc. 1983 16 The Preparation of Highly Reactive Metals and the Development of Novel Organometallic Rieke, Reuben D. Rieke Metals, Inc. 2000 33 Reagents The Preparation of Optically Active α-Amino Acids from the Benzophenone Imines of Glycine O’Donnell, Martin J. Indiana University Purdue 2001 34 Derivatives University Indianapolis (IUPUI) The Role of Silver Salts in Organic Processes Long, John R. Aldrich Chemical Co., Inc. 1981 14 The Spectacular Resurgence of Electrochemical Redox Reactions in Organic Synthesis Echeverria, Pierre-Georges Minakem Recherche 2018 51 Delbrayelle, Dominique; Letort, Aurélien; Nomertin, Fiona; Perez, Marc; Petit, Laurent The Super Silyl Group in Diastereoselective Aldol and Cascade Reactions Boxer, Matthew B.; Albert, Brian J.; University of Chicago 2009 42 Yamamoto, Hisashi The Synthesis of Labeled Compounds via Organoboranes Kabalka, George W. University of Tennessee at 1986 19 Knoxville The Synthesis of Polyquinanes and Polyquinenes via the Weiss Reaction Fu, Xiaoyong; Cook, James M. University of Wisconsin at 1992 25 Milwaukee The Synthetic Potential of the Intramolecular meta-Photocycloaddition in Arene-Alkene De Keukeleire, Denis University of Gent 1994 27 Bichromophoric Systems Containing Oxygen in the Tether The Trouble with Synthesis Cornforth, John Warcup University of Sussex 1994 27 The Use of Acronyms in Organic Chemistry Daub, Guido H.; Leon, Alberto A.; University of New Mexico, Harvey 1984 17 Silverman, I. Robert; Daub, G. Mudd College, and Imperial William; Walker, S. Barrie Chemical Industries To Search, press CTRL+F 47 TITLE Authors Affiliation Year Vol. The Use of Carbon-13-Labeled Compounds in Organic Chemistry, Biochemistry and Leete, Edward; Porwoll, Joseph University of Minnesota and 1985 18 Medicine Aldrich Chemical Co., Inc. The Use of Polymethylhydrosiloxane (PMHS) as a Reducing Agent for Organic Compounds Lipowitz, Jonathan; Bowman, Dow Corning Corp. 1973 6 Sheryl A. The Use of the Aldrich-Nicolet IR Peak-Search and Retrieval Programs in Introductory Szafran, Zvi; Pike, Ronald M.; Merrimack College 1986 19 Chemical Instrumentation Davis, J. David The Utility of Chiral Organoboranes in the Preparation of Optically Active Compounds Srebnik, Morris; Ramachandran, P. Aldrich Chemical Co., Inc. and 1987 20 Veeraraghavan Purdue University The Versatile Boranes Lane, Clinton F. Aldrich-Boranes, Inc. 1973 6 The Wittig Reaction Hopps, Harvey B.; Biel, John H. Aldrich Chemical Co., Inc. 1969 2 Thiazole-Based Routes to Amino Hydroxy Aldehydes, and Their Use for the Synthesis of Dondoni, Alessandro; Perrone, Universita di Ferrara 1997 30 Biologically Active Compounds Daniela 5-Thio-D-glucose: How Do Enzymes Work? Frost, John W. Harvard University 1983 16 Tilorone, Its Analogs, and Developments in Chemical Immunology Levin, Robert H. Consultant (Research & 1979 12 Management) Tin Reagents for Organic Synthesis Bristow, Garry S. Aldrich Chemical Co., Ltd. 1984 17 (England) Titanium Salalen Catalysts for the Asymmetric Epoxidation of Terminal (and Other Berkessel, Albrecht University of Cologne, Germany 2019 52 Unactivated) Olefins with Hydrogen Peroxide To Live for Wisdom—An Appreciation of Herbert C. Brown Brewster, James H. Purdue University 1987 20 Toward a Sustainability Mindset in the Practice of Pharmaceutical Chemistry—from Early Galloua, Fabrice; Novartis Pharma AG; 2015 48 Discovery to Manufacturing Hamann, Lawrence G. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts TPAP: Tetra-n-propylammonium Perruthenate, a Mild and Convenient Oxidant for Alcohols Griffith, William P.; Ley, Steven V. 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University of California at Los 1979 12 Angeles Triethylamine Tris(hydrogen fluoride): Applications in Synthesis McClinton, Martin A. FAR Research Inc. 1995 28 Triflic Acid and Its Derivatives Stang, Peter J.; White, Mitchell R. University of Utah 1983 16

Trimethylsilyldiazomethane (TMSCHN2) in Carbon–Carbon and Carbon–Heteroatom Bond- Lee, Daesung University of Illinois at Chicago 2018 15 Forming Reactions Gupta, Saswata

To Search, press CTRL+F 48 TITLE Authors Affiliation Year Vol. TRIP—A Powerful Brønsted Acid Catalyst for Asymmetric Synthesis Adair, Gareth; Mukherjee, Santanu; Max-Planck-Institut für 2008 41 List, Benjamin Kohlenforschung Ultrasound in Organic Synthesis Abdulla, Riaz F. Lilly Research Laboratories 1988 21 Understanding and Controlling Diastereofacial Selectivity in Carbon-Carbon Bond-Forming Heathcock, Clayton H. University of California at Berkeley 1990 23 Reactions What a Journey It Has Been! Firsan, Sharbil J. Sigma-Aldrich Corp. 2007 40 Where We Should Focus Green Chemistry Efforts Warner, John C. Warner Babcock Institute for 2015 48 Green Chemistry Ynamides: Powerful and Versatile Reagents for Chemical Synthesis Evano, Gwilherm; Theunissen, Université Libre de Bruxelles (ULB) 2015 48 Cédric; Lecomte, Morgan

To Search, press CTRL+F 49 Affiliations AFFILIATION Authors Title Year Vol. Akzo Research Labs, The Netherlands Wiersum, U.E. Preparative Flash-Vacuum Thermolysis. The Revival of Pyrolytic Synthesis 1984 17 Akzo Research Labs, The Netherlands Wiersum, U.E. Isobenzofuran and Related o-Quinonoid Systems—A New Group of Synthetic 1981 14 Intermediates Aldrich Chemical Co., Inc. Firsan, Sharbil J. A Half Century of Chemists Helping Chemists: Aldrich from 1951 to 2001 2001 34 Aldrich Chemical Co., Inc. Higbee, W. Edward A Portrait of Aldrich Chemical Company 1968 1 Aldrich Chemical Co., Inc. Green, Floyd J. A Status Report on Biological Stains 1978 11 Aldrich Chemical Co., Inc. Anonymous Better Computer Searches from Aldrich 1972 5 Aldrich Chemical Co., Inc. Li, J.P. Bifunctional Catalysis 1972 5 Aldrich Chemical Co., Inc. Biel, John H. Biogenic Amines and the Emotional State 1968 1 Aldrich Chemical Co., Inc. Kulkarni, Yashwant S. Carboxyolefination 1990 23 Aldrich Chemical Co., Inc. Bader, Alfred R. Chemistry and Art 1968 1 Aldrich Chemical Co., Inc. Biel, John H.; Warawa, E.J. Chemistry of the Quinuclidines 1968 1 Aldrich Chemical Co., Inc. Szabo, William A.; Lee, H.T. Chiral Starting Materials and Reagents—An Outline of Recent Synthetic Applications 1980 13 Aldrich Chemical Co., Inc. Szabo, William A. Chlorosulfonyl Isocyanate: Silver Anniversary of a Lively Heterocumulene 1977 10 Aldrich Chemical Co., Inc. Bader, Alfred R. Cornelis Bega’s Alchemist: A Problem in Art History 1971 4 Aldrich Chemical Co., Inc. Editor Correct Structures for Benzyl (+)- and (-)-glycidyl ether 1994 27 Aldrich Chemical Co., Inc. Editorial Staff Correction to Starburst/Cascade Dendrimers: Fundamental Building Blocks for a New 1994 27 Nanoscopic Chemistry Set Aldrich Chemical Co., Inc. Dhar, Raj K. Diisopinocampheylchloroborane, (DIP-Chloride), an Excellent Chiral Reducing 1994 27 Reagent for the Synthesis of Secondary Alcohols of High Enantiomeric Purity Aldrich Chemical Co., Inc. Clark, Anthony M. Dutch Art and the Aldrich Collection 1968 1 Aldrich Chemical Co., Inc. Hewitt, Christopher D.; Fluoroaromatic Compounds: Synthesis, Reactions and Commercial Applications 1988 21 Silvester, Michael J. Aldrich Chemical Co., Inc. Buth, William F. Fragment Information Retrieval of Structures 1968 1 Aldrich Chemical Co., Inc. Harvey, David R. Highlights 1975 8 Aldrich Chemical Co., Inc. Ferosie, Ishak Isonitriles 1971 4 Aldrich Chemical Co., Inc. Campbell, John R. Lanthanide Chemical Shift Reagents 1971 4 Aldrich Chemical Co., Inc. Bader, Alfred R. Liquid Crystals and Modern Art 1970 3 Aldrich Chemical Co., Inc. Bader, Alfred R. Of Things to Come 1968 1 Aldrich Chemical Co., Inc. Bader, Alfred R. Prague Revisited 1969 2 Aldrich Chemical Co., Inc. Hopps, Harvey B. Preparation and Reactions of Diazomethane 1970 3 Aldrich Chemical Co., Inc. Marshman, Robert W. Rare Earth Triflates in Organic Synthesis 1995 28 Aldrich Chemical Co., Inc. Bader, Alfred R. Recent Advances in Synthetic Pyrethroids 1976 9 Aldrich Chemical Co., Inc. Black, T. Howard Recent Applications of Homogeneous Catalysis to Organic Synthesis 1982 15

To Search, press CTRL+F 50 AFFILIATION Authors Title Year Vol. Aldrich Chemical Co., Inc. Newaz, S.S. Recent Methods for the Synthesis of Conjugated Lactones 1977 10 Aldrich Chemical Co., Inc. Kulkarni, Yashwant S. Serine Derivatives in Organic Synthesis 1999 32 Aldrich Chemical Co., Inc. Klundt, Irwin L. Synthesis of Benzocyclobutene and Derivatives 1970 3 Aldrich Chemical Co., Inc. Bader, Alfred R. Thallium Chemistry: A Study in International Cooperation 1970 3 Aldrich Chemical Co., Inc. Griffiths, David W. The Aldrich First System of Information Retrieval 1974 7 Aldrich Chemical Co., Inc. Griffiths, David W. The Aldrich FIRST System of Information Retrieval—An Update 1985 18 Aldrich Chemical Co., Inc. Crockett, Geoffrey C. The Chemical Synthesis of DNA 1983 16 Aldrich Chemical Co., Inc. Koppel, Henry The Compleat Chemists 1968 1 Aldrich Chemical Co., Inc. Campbell, John The Determination of Optical and Enantiomeric Purity by Nuclear Magnetic 1972 5 Resonance Spectroscopy (NMR) Aldrich Chemical Co., Inc. Recatto, Craig A. The Intermediacy of Transition-Metal Silicon-Bonded Complexes: Recent 1995 28 Developments Aldrich Chemical Co., Inc. Black, T. Howard The Preparation and Reactions of Diazomethane 1983 16 Aldrich Chemical Co., Inc. Long, John R. The Role of Silver Salts in Organic Processes 1981 14 Aldrich Chemical Co., Inc. Hopps, Harvey B.; Biel, John H. The Wittig Reaction 1969 2 Aldrich Chemical Co., Inc. Anonymous A Brief Survey of Polymer Chemistry 1974 7 Aldrich Chemical Co., Inc. Anonymous Chemical Reactions of Polymers 1975 8 Aldrich Chemical Co., Inc. Anonymous Special Reagents for Thiol Groups 1971 4 Aldrich Chemical Co., Inc. Kanth, Josyula V. B. Borane-Amine Complexes for Hydroboration 2002 35 Aldrich Chemical Co., Inc. Firsan, Sharbil J. Herbert C. Brown and Aldrich 2002 35 Aldrich-Boranes, Inc. and Purdue Lane, Clinton F.; Kramer, Gary W. Handling Air-Sensitive Reagents 1977 10 University Aldrich Chemical Co., Inc. and Purdue Srebnik, Morris; Ramachandran, P. The Utility of Chiral Organoboranes in the Preparation of Optically Active Compounds 1987 20 University Veeraraghavan Aldrich Chemical Co., Ltd. (England) Bader, Alfred R. How to Find a Great Herbicide 1988 21 Aldrich Chemical Co., Ltd. (England) Bristow, Garry S. Tin Reagents for Organic Synthesis 1984 17 Aldrich Chemical Co., Ltd. (England) Silvester, Michael J. Fluoroheterocyclic Compounds: Synthesis, Reactions, and Commercial Applications 1991 24 Aldrich-Boranes, Inc. Lane, Clinton F. Organic Synthesis via Organoboranes: II. Selective Reductions Using Borane- 1974 7 Tetrahydrofuran Complex Aldrich-Boranes, Inc. Lane, Clinton F. Organic Synthesis via Organoboranes: III. Ester Reductions with Super-Hydride 1974 7 Aldrich-Boranes, Inc. Lane, Clinton F. Organic Synthesis via Organoboranes: IV. Reduction of Organic Functional Groups 1975 8 with Borane-Methyl Sulfide Aldrich-Boranes, Inc. Lane, Clinton F. Selective Reduction of the Carbonyl Group in α,β-Unsaturated Aldehydes and 1976 9 Ketones Aldrich-Boranes, Inc. Lane, Clinton F. Selective Reductions Using Borane Complexes 1977 10 Aldrich-Boranes, Inc. Lane, Clinton F. Sodium Cyanoborohydride: A Highly Selective Reducing Agent 1975 8 Aldrich-Boranes, Inc. Lane, Clinton F. The Borane-Amine Complexes 1973 6 Aldrich-Boranes, Inc. Lane, Clinton F. The Versatile Boranes 1973 6

To Search, press CTRL+F 51 AFFILIATION Authors Title Year Vol. Amarillo College Hopps, Harvey B. Purpald®: A Reagent That Turns Aldehydes Purple! 2000 33 American Chemical Society Constable, David J. C. Moving Toward a Green Chemistry and Engineering Design Ethic 2015 48 American Chemical Society Ritter, Stephen K. Taking a Measure of Green Success 2015 48 Amgen Inc. Tucker, John L. Pharmaceutical Green Chemistry at Amgen: Seeing with New Eyes 2015 48 Avecia Pharmaceuticals and Syngenta Pears, David A.; Smith, Stephen C. Polyurea-Encapsulated Palladium Catalysts: The Development and Application of a 2005 38 New and Versatile Immobilized-Homogeneous- Catalyst Technology Bioscience Consulting Services Hermanson, Greg T. Bioconjugation—A Versatile and Essential Research Tool 2017 50 Boehringer Ingelheim Senanayake, Chris H.; Krishnamurthy, Enantiopure Sulfoxides and Sulfinamides: Recent Developments in Their 2005 38 Pharmaceuticals, Inc. Dhileepkumar; Lu, Zhi-Hui; Han, Stereoselective Synthesis and Applications to Asymmetric Synthesis Zhengxu; Gallou, Isabelle Brandeis University Abeles, Robert H. A Methionine Salvage Pathway 1992 25 Brunel University Wallace, Raymond G. Hydroxylamine-O-sulfonic Acid—A Versatile Synthetic Reagent 1980 13 Bryn Mawr College, University of Schmink, Jason R.; Bellomo, Ana; Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia 2013 46 Pennsylvania Berritt, Simon and Industry C&EN 1968, 46 (Sept. 2), 26-27; Anonymous Computer Aids Search for R&D Chemicals 1969 2 (Reprinted from) California Institute of Technology Dervan, Peter B. John D. Roberts 1988 21 California Institute of Technology Gray, Harry B. Long-Range Electron Transfer in Proteins 1990 23 California Institute of Technology Lelais, Gerald; MacMillan, David W. C. Modern Strategies in Organic Catalysis: The Advent and Development of Iminium 2006 39 Activation California Institute of Technology Evans, David A. Studies in Asymmetric Synthesis. The Development of Practical Chiral Enolate 1982 15 Synthons California State University, Northridge Melikyan, Gagik G. Manganese-Based Organic and Bioinorganic Transformations 1998 31 Cambridge University Williams, Dudley H. Ralph Alexander Raphael: A Lover of Acetylenes at 65 1986 19 Case Western Reserve University Olah, George A. Carbocation and Onium Ion Reagents 1973 6 CEM Corporation Hayes, Brittany L. Recent Advances in Microwave-Assisted Synthesis 2004 37 Central Leather Research Institute Babu, G. Perumal, P. T. Synthetic Applications of Indium Trichloride Catalyzed Reactions 2000 33 (Chennai, India) Central Queensland University Warrener, Ronald N.; Butler, Douglas N. Dimethyl Tricylclo[4.2.1.02,5]nona-3,7-diene-3,4-dicarboxylate: A Versatile 1997 30 Ambident Dienophile Centre for Agrochem. Res. (Guindy, Narasimhan, S.; Balakumar, R. Synthetic Applications of Zinc Borohydride 1998 31 India) Chemsampco, Inc. Greenlee, Kenneth W. A Small Chemical Businessman Looks at Premanufacture Notification (PMN) 1979 12 China Agricultural University and The Yumei, Xiao; Guo, Hongchao; Kwon, Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric 2016 49 University of California, Los Angeles Ohyun Kwon Annulations CLEA Technologies B.V. Sheldon, Roger A. van Pelt, Sander; Cross-Linked Enzyme Aggregates (CLEAs) in Organic Synthesis 2013 46 Kanbak-Aksu, Seda; Rasmussen, Jo‑Anne; Janssen, Michiel H. A. Colorado State University Vora, Harit U.; Rovis, Tomislav Asymmetric N-Heterocyclic Carbene (NHC) Catalyzed Acyl Anion Reactions 2011 44 Colorado State University Williams, Robert M. Asymmetric Syntheses of α-Amino Acids 1992 25

To Search, press CTRL+F 52 AFFILIATION Authors Title Year Vol. Colorado State University Meyers, Albert I. Formamidines as Precursors to α-Amino Carbanions and their Application to 1985 18 Asymmetric C-C Bond-Forming Reactions Colorado State University Miyake, Garret M. Phenothiazines, Dihydrophenazines, and Phenoxazines: Sustainable Alternatives to 2019 52 Corbin, Daniel A.; Lim, Chern-Hooi Precious-Metal-Based Photoredox Catalysts Columbia University Hoffman, Frances Gilbert Stork: A Celebration of 35 Years in Research & Teaching 1982 15 Columbia University Snyder, Scott A.; Treitler, Daniel S.; Halonium-Induced Cyclization Reactions 2011 44 Brucks, Alexandria P. Columbia University Leighton, James L. Powerful and Versatile Silicon Lewis Acids for Asymmetric Chemical Synthesis 2010 43 CONICET-Universidad Nacional de Mascaretti, Oreste A. Modern Methods for the Monofluorination of Aliphatic Organic Compounds. 1993 26 Rosario Nucleophilic Fluoride Transfer Agents CONICET-UNR Mascaretti, Oreste A.; Furlan, Ricardo L.E. Esterifications, Transesterifications, and Deesterifications Mediated by Organotin 1997 30 Oxides, Hydroxides, and Alkoxides Consultant (Research & Management) Levin, Robert H. Tilorone, Its Analogs, and Developments in Chemical Immunology 1979 12 Dalhousie University Lundgren, Rylan J.; Stradiotto, Mark Recent Advances in the Buchwald–Hartwig Amination Reaction Enabled by the 2012 45 Application of Sterically Demanding Phosphine Ancillary Ligands Delft University of Technology, The Sheldon, Roger A. Biocatalysis and Biomass Conversion in Ionic Liquids 2015 48 Netherlands Degussa Beschke, Helmut Chemical Reactions of 2,3-Cycloalkenopyridines 1978 11 Degussa Beschke, Helmut Chemical Reactions of Newly Available Pyridines 1981 14 Dendritic NanoTechnologies, Inc., Tomalia, Donald A. Birth of a New Macromolecular Architecture: Dendrimers as Quantized Building 2004 37 Central Michigan University Blocks for Nanoscale Synthetic Organic Chemistry Dow Corning Corp. Lipowitz, Jonathan; Bowman, Sheryl A. The Use of Polymethylhydrosiloxane (PMHS) as a Reducing Agent for Organic 1973 6 Compounds Dynapol Dawson, D.J. Polymeric Dyes 1981 14 Dynapol Crosby, Guy A. Polymeric Reagents 1976 9

Dyson Perrins Laboratory Davies, Stephen G. The Chiral Auxiliary [(C5H5)Fe(CO)(PPh3)] for Asymmetric Synthesis 1990 23 E.I. Du Pont de Nemours & Co., Inc. Pedersen, Charles J. Macrocyclic Polyethers for Complexing Metals 1971 4 ETH-Zürich (Laboratorium für Bode, Jeffrey W.; Luescher, Michael U.; SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of 2015 48 Organische Chemie) Geoghegan, Kimberly; Nichols, Paula L. Saturated N-Heterocycles Eidgenoessischen Technischen Prelog, Vladimir Albert Eschenmoser 1990 23 Hochschule Eidgenoessischen Technischen Seebach, Dieter How We Stumbled into Peptide Chemistry 1992 25 Hochschule Engelhard Minerals and Chemicals Rylander, Paul N. Choosing and Using Noble Metal Hydrogenation Catalysts 1979 12 Corp. Fachhochschule Fresenius Schmidt, Arthur H. Bromotrimethylsilane and Iodotrimethylsilane—Versatile Reagents for Organic 1981 14 Synthesis FAR Research Inc. McClinton, Martin A. Triethylamine Tris(hydrogen fluoride): Applications in Synthesis 1995 28 Federal University of Espírito Santo Greco, Sandro José Greco; Fiorot, Rodolfo Recent Advances in the Prins Cyclization 2013 46 Goetze; Lacerda, Jr., Valdemar; dos Santos, Reginaldo Bezerra

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GEO-Centers, Inc. at ARDEC Bashir-Hashemi, A.; Doyle, Gerald Oxalyl Chloride in Photochemical Chlorocarbonylation of Cage Compounds 1996 29 Hallym University (Korea) Cho, Byung Tae Boron-Based Reducing Agents for the Asymmetric Reduction of Functionalized 2002 35 Ketones and Ketimines Harvard University Frost, John W. 5-Thio-D-glucose: How Do Enzymes Work? 1983 16 Harvard University Mukherjee, Santanu; Corey, E. J. Enantioselective Synthesis Based on Catalysis by Chiral Oxazaborolidinium Cations 2010 43 Harvard University Whitesides, George M.; Wong, C.-H. Enzymes as Catalysts in Organic Synthesis 1983 16 Harvard University Knowles, Jeremy R. Mechanistic Ingenuity in Enzyme Catalysis: Dehydroquinate Synthase 1989 22 Harvard University Kishi, Yoshito Recent Developments in the Chemistry of Natural Products 1980 13 Hyman Laboratories, Inc. 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Recent Applications of Proazaphosphatranes in Organic Synthesis 2004 37 Molecular Research, Inc. Kanata Chemical Technologies, Inc. Amoroso, Dino; Graham, Todd W.; Guo, Aminophosphine Catalysts in Modern Asymmetric Synthesis 2008 41 (Toronto, Canada) Rongwei; Tsang, Chi-Wing; Abdur- Rashid, Kamaluddin Kent State University Fergason, James L. Liquid Crystals and Science 1970 3 Koch-Light Laboratories, Ltd. Epton, R.; Thomas, T.H. Improving Nature’s Catalysts 1971 4 To Search, press CTRL+F 54 AFFILIATION Authors Title Year Vol. Koch-Light Laboratories, Ltd. Epton, Roger Permeation Chromatography of Organic Solutes Using Enzacryl Gel Packings 1976 9 Kurukshetra University Prakash, Om; Singh, Shiv P. Iodobenzene Diacetate and Related Hypervalent Iodine Reagents in the Synthesis of 1994 27 Heterocyclic Compounds Kurukshetra University Prakash, Om Organo Iodine(III) and Thallium(III) Reagents in Organic Synthesis: Useful 1995 28 Methodologies Based on Oxidative Rearrangements Kyoto University Shintani, Ryo; Hayashi, Tamio Chiral Diene Ligands for Asymmetric Catalysis 2009 42 Kyoto University Ooi, Takashi; Maruoka, Keiji Development and Applications of C2-Symmetric, Chiral, Phase-Transfer Catalysts 2007 40 Lilly Research Laboratories Abdulla, Riaz F. Ultrasound in Organic Synthesis 1988 21 Liquid Light Laboratories Gill, Steven K. New Developments in Chemiluminescence Research 1983 16 Loughborough U. of Technology Heaney, Harry Oxidation Reactions Using Magnesium Monoperphthalate and Urea Hydrogen 1993 26 Peroxide Marquette University Donaldson, William A. Preparation and Reactivity of Acyclic (Pentadienyl)iron(1+) Cations: Applications to 1997 30 Organic Synthesis Massachusetts Institute of Technology Masamune, Satoru; Choy, William Advances in Stereochemical Control: The 1,2- and 1,3-Diol Systems 1982 15 Massachusetts Institute of Technology Behrens, Carl H.; Sharpless, K. Barry New Transformations of 2,3-Epoxy Alcohols and Related Derivatives. Easy Routes to 1983 16 Homochiral Substances Materia, Inc. Schrodi, Yann; Pederson, Richard L. 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To Search, press CTRL+F 55 AFFILIATION Authors Title Year Vol. National Institutes of Health Daly, John; Witkop, Bernhard Batrachotoxin, a Novel Steroidal Alkaloid with Selective Effects on Biomembrane 1970 3 Permeability National Institutes of Health May, Everette L. The Evolution of Totally Synthetic, Strong Analgesics 1969 2 National Institutes of Health May, Everette L. The Methadone Story 1972 5 National Research Council of Canada Ingold, Keith U. At the Organic Chemistry/Bioscience Interface: Rate Processes in Complex Systems 1989 22 National Research Council of Canada Smith, Ian C.P. Deuterium NMR—A Useful Technique in Chemistry, Physics, and Biology 1977 10 Naval Medical Research Institute Kiesow, L. A. A Biologic Assimilation of Inorganic Energy 1972 5 Naval Medical Research Institute Friess, S. L. Steroidal Saponin Esters Elaborated by Poisonous Marine Echinoderms 1970 3 New Jersey Institute of Technology Zhao, Hua; Malhotra, Sanjay V. Applications of Ionic Liquids in Organic Synthesis 2002 35 New Science College Koganti, Vara Prasad Atlas of Organic Conversions: An Aid in Perspective 1996 29 North Dakota State University Sibi, Mukund P. Are Two Phenyls Better than One? Synthesis and Applications of 1999 32 (R)-4-Diphenylmethyl-2-oxazolidinone Northern Arizona University Lane, Clinton F. Herbert C. Brown and Aldrich: Advancing Borane Chemistry for 32 Years 2005 38 Northwestern University Phillips, Eric M.; Chan, Audrey; Scheidt, Discovering New Reactions with N-Heterocyclic Carbene Catalysis 2009 42 Karl A. Novartis Pharma AG; Novartis Galloua, Fabrice; Hamann, Lawrence G. Toward a Sustainability Mindset in the Practice of Pharmaceutical Chemistry—from 2015 48 Institutes for BioMedical Research, Early Discovery to Manufacturing Cambridge, Massachusetts NSC Technologies & NutraSweet Ager, David J.; Prakash, Indra; Schaad, Chiral Oxazolidinones in Asymmetric Synthesis 1997 30 Kelco Co. (Units of Monsanto) David R. Ohio State University Magnus, Philip Organosilicon Reagents for Carbon-Carbon Bond-Forming Reactions 1980 13 Ohio State University Paquette, Leo A. Synthetic Routes to Cyclopentanoid-Fused Unnatural and Natural Products 1984 17 Oklahoma State University Senaweera, Sameera Photocatalytic C–F Reduction and Functionalization 2016 49 Weaver, Jimmie D. Olin Corporation Schiessl, Henry W. Hydrazine—Rocket Fuel to Synthetic Tool 1980 13 Oxford University Harwood, Lawrence M. Dry-Column Flash Chromatography 1985 18 Pennsylvania State University Mullen, Thomas J.; Dameron, Arrelaine Selecting and Driving Monolayer Structures through Tailored Intermolecular 2007 40 A.; Andrews, Anne M.; Weiss, Paul S. Interactions Princeton University & U. of East Taylor, Edward C.; McKillop, Alexander Organothallium Chemistry—New Horizons in Synthesis 1970 3 Anglia Purdue University Brown, Herbert C.; Krishnamurthy, S. Boranes for Organic Reductions—A Forty-Year Odyssey 1979 12 Purdue University Brown, Herbert C. New Reagents for Hydroboration and for Synthesis via Boranes 1974 7 Purdue University Davenport, Derek A. On Opinion in Good Men: An Oblique Tribute to H.C. Brown 1987 20 Purdue University Negishi, Ei-ichi; Takahashi, Tamotsu Organozirconium Compounds as New Reagents and Intermediates 1985 18 Purdue University Negishi, Ei-ichi; Hu, Qian; Huang, Palladium-Catalyzed Alkenylation by the Negishi Coupling 2005 38 Zhihong; Qian, Mingxing; Wang, Guangwei Purdue University Ramachandran, P. Veeraraghavan Pinane-Based Versatile Allylboranes 2002 35 Purdue University Brown, Herbert C.; Campbell, James B., Synthesis and Applications of Vinylic Organoboranes 1981 14 Jr. Purdue University Kornblum, Nathan Synthetic Aspects of Electron-Transfer Chemistry 1990 23 To Search, press CTRL+F 56 AFFILIATION Authors Title Year Vol. Purdue University Brewster, James H. To Live for Wisdom—An Appreciation of Herbert C. Brown 1987 20 Purdue University Krishnamurthy, S. Trialkylborohydrides as New Versatile Reducing Agents in Organic Synthesis 1974 7 Queen’s University, Kingston, Jessop, Philip G. Switchable Solvents as Media for Synthesis and Separations 2015 48 Ontario, Canada Reilly Industries, Inc. Murugan, Ramiah Applications of Dialkylaminopyridine (DMAP) Catalysts in Organic Synthesis 2003 36 Research Institute for Pharmacy and Radl, Stanislav Crisscross Cycloaddition Reactions 1997 30 Biochemistry (Prague) Rhodia Recherches et Technologies Mauger, Christelle C.; Mignani, Gerard A. Synthetic Applications of Buchwald’s Phosphines in Palladium-Catalyzed Aromatic- 2006 39 Bond-Forming Reactions Rice University James, Dustin K.; Tour, James M. Organic Synthesis and Device Testing for Molecular Electronics 2006 39 Rieke Metals, Inc. Rieke, Reuben D. The Preparation of Highly Reactive Metals and the Development of Novel 2000 33 Organometallic Reagents Rohm and Haas Co. Hormann, Robert E. Nonnatural Products Nonpareil 1996 29 Royal Institute of Technology Sjoeberg, Kjell PTC in PracTiCe 1980 13 Ruprecht-Karls-Universität Heidelberg Hashmi, A. Stephen K.; Bührle, Miriam Gold-Catalysed Addition of X-H Bonds to C-C Multiple Bonds 2010 43 Science University of Tokyo Mukaiyama, Teruaki New Possibilities in Organic Synthesis 1996 29 Scripps Research Institute, The Wu, Peng; Fokin, Valery V. Catalytic Azide-Alkyne Cycloaddition: Reactivity and Applications 2007 40 Sepracor, Inc. Senanayake, Chris H. Applications of cis-1-Amino-2-indanol in Asymmetric Synthesis 1998 31 Shanghai Institute of Organic Ma, Shengming Recent Advances in the Chemistry of Allenes 2007 40 Chemistry Sigma- London Balding, Peter; Humphryes, Ken C. Lectins 1983 16 Sigma-Aldrich Chemical Co., Ltd. Silvester, Michael J. Polyfluorinated Alkenes, Alkynes, and Allenes 1995 28 Sigma-Aldrich Company Ltd. Amery, Gordon Reactive Chemical Hazard Evaluation in the Scale-Up of Chemical Processes 2001 34 (Gillingham) Sigma-Aldrich Corp. Firsan, Sharbil J. Remembering Dr. Jai P. Nagarkatti (1947–2010) 2010 43 Sigma-Aldrich Corp. Firsan, Sharbil J. What a Journey It Has Been! 2007 40 Sigma-Aldrich Corp. (Milwaukee) Firsan, Sharbil J. Please Call Me Alfred (Editorial) 2009 42 Sigma-Aldrich Corp., M. Emanuel, Cori, Tom; Emanuel, Ralph N.; Harvey, Our Chemist-Collector Approaches Sixty 1984 17 Ltd., Aldrich Chemical Co., and David; Klitsner, Marvin E. Foley & Lardner Sloan-Kettering Institute for Cancer Seeberger, P.H.; Bilodeau, M.T.; Synthesis of Biologically Important Oligosaccharides and Other Glycoconjugates by 1997 30 Research Danishefsky, S.J. the Glycal Assembly Method Slovak Technical University Milata, Viktor Alkoxymethylenemalonates in Organic Synthesis 2001 34 Sogang University; Hankuk University Lee, Won Koo; Ha, Hyun-Joon Highlights of the Chemistry of Enantiomerically Pure Aziridine-2-carboxylates 2003 36 of Foreign Studies (Korea) Stanford University Sharpless, K. Barry; Verhoeven, Thomas Metal-Catalyzed, Highly Selective Oxygenations of Olefins and Acetylenes with tert- 1979 12 R. Butyl Hydroperoxide. Practical Considerations and Mechanisms. Stanford University Trost, Barry M.; Fandrick, Daniel R. Palladium-Catalyzed Dynamic Kinetic Asymmetric Allylic Alkylation with the DPPBA 2007 40 Ligands

To Search, press CTRL+F 57 AFFILIATION Authors Title Year Vol. State University of New York at Davies, Huw M.L. Asymmetric Synthesis Using Rhodium-Stabilized Vinylcarbenoid Intermediates 1997 30 Buffalo Technische Universität Kaiserslautern Patureau, Frederic W.; Wencel-Delord, Cp*Rh-Catalyzed C-H Activations: Versatile Dehydrogenative Cross-Couplings of 2012 45 and Westfalische Wilhelms-Universitat Joanna; Glorius, Frank Csp2 C-H Positions with Olefins, Alkynes, and Arenes Munster Texas A&M University Barton, Derek H. R. The Invention of Chemical Reactions 1990 23 Texas A&M University Gladysz, John A.; Mukherjee, Tathagata Fluorous Chemistry Meets Green Chemistry: A Concise Primer 2015 48 Texas A&M University-Commerce Headley, Allan D.; Ni, Bukuo Chiral Imidazolium Ionic Liquids: Their Synthesis and Influence on the Outcome of 2007 40 Organic Reactions Texas Christian U. Gutsche, C. David Calixarenes 1995 28 The Ohio State University Wieting, Joshua M.; Hardman-Baldwin, Silanediol Recognition in Catalysis, Sensing, and Drug Discovery 2016 49 Andrea M.; Visco, Michael D.; Mattson, Anita E. The Pennsylvania State U. and State Gokel, George W.; Durst, H. Dupont Crown Ether Chemistry: Principles and Applications 1976 9 U of New York at Buffalo The Scripps Research Institute Engle, Keary M. Carbon–Carbon π Bonds as Conjunctive Reagents in Cross-Coupling 2018 51 Derosa, Joseph; Tran, Van T.; van der Puyl, Vincent A. The Scripps Research Institute Toy, Patrick H.; Reger, Thomas S.; Tailoring Polystyrene Solid-Phase Synthesis Resins: Incorporation of Flexible Cross- 2000 33 Janda, Kim D. Linkers The Scripps Research Institute Whalen, Lisa J.; Wong, Chi-Huey Enzymes in Organic Synthesis: Aldolase-Mediated Synthesis of Iminocyclitols and 2006 39 Novel Heterocycles The University of Akron Koser, Gerald F. [Hydroxy(tosyloxy)iodo]benzene and Closely Related Iodanes: The Second Stage of 2001 34 Development The University of Alabama Rogers, Robin D.; Kelley, Steven P. A Practical Overview of Organic Synthesis in Ionic Liquids 2015 48 University of California, Santa Lipshutz, Bruce H.; Ghoraib, Subir Green Chemistry in the Introductory Organic Laboratory 2015 48 Barbara; Sigma-Aldrich Corp. The University of Edinburgh McNab, Hamish Chemistry Without Reagents: Synthetic Applications of Flash Vacuum Pyrolysis 2004 37 The University of Goettingen Roesky, Herbert W. Hydroalumination Reactions in Organic Chemistry 2004 37 The University of Kansas Harned, Andrew M.; Zhang, Mianji; ROM Polymerization in Facilitated Synthesis 2005 38 Vedantham, Punitha; Mukherjee, Shubhasish; Herpel, Russell H.; Flynn, Daniel L.; Hanson, Paul R. The University of Liverpool Gilchrist, Thomas L. Activated 2H-Azirines as Dienophiles and Electrophiles 2001 34 The University of Liverpool Lauret, Christelle; Roberts, Stanley M. Asymmetric Epoxidation of α, β-Unsaturated Ketones Catalyzed by Poly(amino acids) 2002 35 The University of Pennsylvania Molander, Gary A.; Figueroa, Ruth Organotrifluoroborates: Expanding Organoboron Chemistry 2005 38 University of Texas at Austin Krische, Michael J.; Shin, Inji; Catalytic C–C Bond Formation and the Hendricksonian Ideal: Atom- and Redox- 2015 48 Montgomery, T. Patrick Economy, Stereo- and Site-Selectivity The University of Tokyo Fukuyama, Tohru; Tokuyama, Hidetoshi Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters 2004 37 Tohoku University Yamamoto, Yoshinori Allylic Tin Compounds in Organic Synthesis 1987 20

To Search, press CTRL+F 58 AFFILIATION Authors Title Year Vol. Trinity University Doyle, Michael P. Chiral Dirhodium Carboxamidates: Catalysts for Highly Enantioselective Syntheses 1996 29 of Lactones and Lactams Universidad de Castilla-La Mancha Seoane, Carlos Teaching Organic Synthesis: Why, How, What? 1989 22 Universidad de Oviedo Barluenga, Jose; Suarez-Sobrino, A.; Chiral Heterosubstituted 1,3-Butadienes: Synthesis and [4+2] Cycloaddition 1999 32 Lopez, Luis A. Reactions Universidade de Sao Paulo Comasseto, Joao V.; Barrientos- Add a Little Tellurium to Your Synthetic Plans! 2000 33 Astigarraga, Rafael E. Universidade Federal do Espírito Greco, Sandro José; Lacerda, Valdemar, Recent Advances in the Asymmetric Catalytic Mannich Reaction 2011 44 Santo (Brasil) Jr.; dos Santos, Reginaldo Bezerra Universidade Federal do Espírito Lacerda, Valdemar, Jr.; Dos Santos, The Growing Impact of Niobium in Organic Synthesis and Catalysis 2012 45 Santo and Universidade Estadual Deborah Araujo; da Silva-Filho, Luiz Paulista (Brasil) Carlos; Greco, Sandro José; dos Santos, Reginaldo Bezerra Universita di Bologna Cardillo, Giuliana; Gentilucci, Luca; Aziridines and Oxazolines: Valuable Intermediates in the Synthesis of Unusual Amino 2003 36 Tolomelli, Alessandra Acids Università Ca’ Foscari, Venezia (Italy) Perosa, Alvise; Cattelan, Lisa; Fiorani, Greener and Sustainable Applications of Phosphorus and Sulfur Ylides 2018 51 Giulia; Selva, Maurizio Universita di Ferrara Dondoni, Alessandro; Perrone, Daniela Thiazole-Based Routes to Amino Hydroxy Aldehydes, and Their Use for the Synthesis 1997 30 of Biologically Active Compounds Universite de Liege Laszlo, Pierre; Cornelis, Andre CLAYCOP, a User-Friendly Oxidizing and Nitrating Reagent 1988 21 Université de Montréal Collins, Shawn K.; Godin, Éric; Continuous-Flow Macrocyclization 2018 51 Morin, Émilie Université de Montréal Hanessian, Stephen Design and Implementation of Tactically Novel Strategies for Stereochemical Control 1989 22 Using the Chiron Approach Université de Montréal Lemire, Alexandre; Côté, Alexandre; Synthesis and Applications of Diorganozinc Reagents: Beyond Diethylzinc 2009 42 Janes, Marc K.; Charette, André B. Universite de Sherbrooke Deslongchamps, Pierre The Concept of Strategy in Organic Synthesis 1984 17 Universite de Sherbrooke Deslongchamps, Pierre Transannular Diels-Alder Reaction on Macrocycles: A General Strategy for the 1991 24 Synthesis of Polycyclic Compounds Université Européenne de Bretagne Wencel, Joanna; Mauduit, Marc; Hénon, Chiral, Chelating, Hydroxyalkyl and Hydroxyaryl N-Heterocyclic Carbenes: Design, 2009 42 and Université de Genève Hélène; Kehrli, Stefan; Alexakis, Synthesis, and Application in Copper-Catalyzed Asymmetric Conjugate Addition (Cu- Alexandre ACA) University College London Crich, David O-Acyl Thiohydroxamates: New and Versatile Sources of Alkyl Radicals for Use in 1987 20 Organic Synthesis Université Libre de Bruxelles (ULB) Evano, Gwilherm; Theunissen, Cédric; Ynamides: Powerful and Versatile Reagents for Chemical Synthesis 2015 48 Lecomte, Morgan University of Alberta Clive, Derrick L. J. Selenium Reagents for Organic Synthesis 1978 11 University of Alberta Hall, Dennis G.; Zheng, Hongchao Boronic Acid Catalysis: an Atom-Economical Platform for Direct Activation and 2014 47 Functionalization of Carboxylic Acids and Alcohols University of Alberta Masamune, Satoru Recent Progress in Macrolide Synthesis 1978 11 University of Arizona, The Hall, H.K., Jr.; Padias, Buyle Spontaneous Polymerizations Can Occur During Cycloaddition Reactions of Olefins 1995 28 and Dienes

To Search, press CTRL+F 59 AFFILIATION Authors Title Year Vol. University of Bologna, “G. Ciamician” Tolomelli, Alessandra; Ferrazzano, Lucia; 4-Substituted Prolines: Useful Reagents in Enantioselective Synthesis and 2017 50 Amoroso, Rosa Conformational Restraints in the Design of Bioactive Peptidomimetics University of British Columbia Dolphin, David Robert Burns Woodward: Three Score Years and Then? 1977 10 University of California at Berkeley Heathcock, Clayton H. Understanding and Controlling Diastereofacial Selectivity in Carbon-Carbon Bond- 1990 23 Forming Reactions University of California at Irvine Overman, Larry E. New Reactions for Forming Heterocycles and Their Use in Natural Products Synthesis 1995 28 University of California, Irvine Vanderwal, Christopher D. Recent Advances in Alkene Metathesis for Natural Product Synthesis—Striking 2017 50 Atwood, Brian R. Achievements Resulting from Increased Sophistication in Catalyst Design and Synthesis Strategy University of California at Los Angeles Gladysz, J. A. Trialkylborohydrides in Organometallic Syntheses 1979 12 University of California at San Diego Nicolaou, K.C. New Synthetic Methods and Strategies and Total Synthesis of Natural Products 1993 26 University of California at Santa Bruice, Thomas C. The Mechanisms of Oxygen Transfer from Acyl and Alkyl Hydroperoxides to 1988 21 Barbara Metal(III) Porphyrins and the Epoxidation of Alkenes by the Resultant Hypervalent Metal-Oxo Porphyrin Products University of California, Berkeley Baskin, Jeremy M.; Bertozzi, Carolyn R. Copper-Free Click Chemistry: Bioorthogonal Reagents for Tagging Azides 2010 43 University of California, Santa Lipshutz, Bruce H.; Ghorai, Subir Transition-Metal-Catalyzed Cross-Couplings Going Green: in Water at Room 2008 41 Barbara Tempreature University of California, Santa Lipshutz, Bruce H.; Ghorai, Subir “Designer” - Surfactant-Enabled Cross-Couplings in Water at Room Temperature 2012 45 Barbara, and Sigma-Aldrich Co. University of California, Santa Cruz Pasumansky, Lubov; Singaram, Bakthan; Recent Advances in the Chemistry of Lithium Aminoborohydrides 2005 38 Goralski, Christian T. University of Cambridge Williams, Dudley H. The Molecular Basis of Biological Order 1991 24 University of Cambridge Williams, Dudley H. The Molecular Basis of Biological Order and Amide-Amide Hydrogen Bonds-An 1992 25 Addendum University of Cambridge (U.K.) Longbottom, Deborah A.; Franckevicius, Practical Organocatalysis with (S)- and (R)-5-Pyrrolidin-2-yl- 1H-tetrazoles 2008 41 Vilius; Kumarn, Sirirat; Oelke, Alexander J.; Wascholowski, Veit; Ley, Steven V. University of Canterbury Vernall, Andrea J.; Abell, Andrew D. Cross Metathesis of Nitrogen-Containing Systems 2003 36 University of Canterbury, New Phillips, Andrew J.; Abell, Andrew D. Ring-Closing Metathesis of Nitrogen-Containing Compounds: Applications to 1999 32 Zealand Heterocycles, Alkaloids, and Peptidomimetics University of Central Florida Gupton, John T. Some Useful Synthetic Applications of Gold’s Reagent 1986 19 University of Chicago Boxer, Matthew B.; Albert, Brian J.; The Super Silyl Group in Diastereoselective Aldol and Cascade Reactions 2009 42 Yamamoto, Hisashi University of Chicago Bosnich, Brice Transition-Metal-Based Lewis Acid Catalysts 1998 31 University of Cologne, Germany Berkessel, Albrecht Titanium Salalen Catalysts for the Asymmetric Epoxidation of Terminal (and Other 2019 52 Unactivated) Olefins with Hydrogen Peroxide University of Colorado Kime, Katherine A.; Sievers, Robert E. A Practical Guide to Uses of Lanthanide NMR Shift Reagents 1977 10 University of Connecticut Leadbeater, Nicholas E.; TEMPO-Derived Oxoammonium Salts as Versatile Oxidizing Agents 2014 47 Bobbitt, James M. University of East Anglia Jones, R. Alan Applications of Phase-Transfer Catalysis in Organic Synthesis 1976 9

To Search, press CTRL+F 60 AFFILIATION Authors Title Year Vol. University of Florida Katritzky, Alan R.; Yang, Zhijun; Cundy, Benzotriazole-Stabilized Carbanions: Generation, Reactivtiy, and Synthetic Utility 1994 27 Darren J. University of Florida, Gainsville Katritzky, Alan R.; Belyakov, Sergei A. Benzotriazole-Based Intermediates: Reagents for Efficient Organic Synthesis 1998 31 University of Florida, Gainsville; Hudlicky, Tomas; Gonzalez, David; Enzymatic Dihydroxylation of Aromatics in Enantioselective Synthesis: Expanding 1999 32 University of Iowa, Iowa City Gibson, David T. Asymmetric Methodology University of Florida, Panda, Siva S.; Hall, C. Dennis; Scriven, Aminoacyl Benzotriazolides: Versatile Reagents for the Preparation of Peptides and 2013 46 King Abdulaziz University Eric; Katritzky, Alan R. Their Mimetics and Conjugates University of Gent De Keukeleire, Denis The Synthetic Potential of the Intramolecular meta-Photocycloaddition in Arene- 1994 27 Alkene Bichromophoric Systems Containing Oxygen in the Tether University of Graz and the Dallinger, Doris; Kappe, C. Oliver Recent Enabling Technologies for Diazomethane 2016 49 Research Center for Pharmaceutical Generation and Reactions Engineering University of Helsinki Hase, Tapio A.; Koskimies, Jorma K. A Compilation of References on Formyl and Acyl Anion Synthons 1981 14 University of Helsinki Hase, Tapio A.; Koskimies, Jorma K. A Compilation of References on R-Functional Acyl Anion Synthons, RCO- 1982 15 University of Houston Cox, James R., Jr.; Willcott, M. Robert, III Deuterium Analysis and Organic Chemistry 1972 5 University of Hyderabad Periasamy, Mariappan Novel Methods of Resolving Racemic Diols and Amino Alcohols 2002 35 University of Illinois at Chicago Dudnik, Alexander S.; Chernyak, Natalia; Copper-, Silver-, and Gold-Catalyzed Migratory Cycloisomerizations Leading to 2010 43 Gevorgyan, Vladimir Heterocyclic Five-Membered Rings

University of Illinois at Chicago Lee, Daesung; Gupta, Saswata Trimethylsilyldiazomethane (TMSCHN2) in Carbon–Carbon and Carbon–Heteroatom 2018 51 Bond-Forming Reactions University of Illinois at Urbana- Chan, Jefferson; Bearrood, Thomas E. Disproportionate Impact of Named Reactions on Chemical Biology 2017 50 Champaign University of Illinois at Urbana- Gillis, Eric P.; Burke, Martin D. Iterative Cross-Coupling with MIDA Boronates: towards a General Strategy for 2009 42 Champaign Small-Molecule Synthesis University of Illinois at Urbana- Denmark, Scott E.; Ober, Michael H. Organosilicon Reagents: Synthesis and Application to Palladium-Catalyzed Cross- 2003 36 Champaign Coupling Reactions University of Louisville Jin, Zhuang; Hammond, Gerald B.; Xu, Bo Transition-Metal-Mediated Fluorination, Difluoromethylation, and 2012 45 Trifluoromethylation University of Michigan Yau, Eric K.; Coward, James K. Filtering-Column Chromatography—A Fast, Convenient Chromatographic Method 1988 21 University of Michigan; Lilly Research Stephenson, Corey R. J., Douglas, James Enabling Novel Photoredox Reactivity via Photocatalyst Selection 2014 47 Laboratories J., Nguyen, John D., Cole, Kevin P. University of Minnesota and Aldrich Leete, Edward; Porwoll, Joseph The Use of Carbon-13-Labeled Compounds in Organic Chemistry, Biochemistry and 1985 18 Chemical Co., Inc. Medicine University of Mississippi Colby, David A.; Sowaileh, Munia F. Fluoroenolate-Enabled Monofluorinations and Difluoromethylations 2018 51 University of Missouri at St. Louis Block, Eric Organic Sulfur Compounds in Organic Synthesis: Some Recent Advances 1978 11 University of New Mexico, Harvey Daub, Guido H.; Leon, Alberto A.; The Use of Acronyms in Organic Chemistry 1984 17 Mudd College, and Imperial Chemical Silverman, I. Robert; Daub, G. William; Industries Walker, S. Barrie University of North Texas Marchand, Alan P. Polycyclic Cage Compounds: Reagents, Substrates, and Materials for the 21st 1995 28 Century University of Nottingham Gill, G. B.; Whiting, D.A. Guidelines for Handling Air-Sensitive Compounds 1986 19

To Search, press CTRL+F 61 AFFILIATION Authors Title Year Vol. University of Ottawa Alper, Howard Simple, Novel Methods for the Synthesis of Carbonyl Compounds Using Metal 1991 24 Complexes as Catalysts University of Ottawa (Canada) Campeau, Louis-Charles; Stuart, David Recent Advances in Intermolecular Direct Arylation Reactions 2007 40 R.; Fagnou, Keith University of Pittsburgh Curran, Dennis P. Highlights from Two Decades of Synthetic Radical Chemistry 2000 33 University of Pittsburgh Curran, Dennis P. Organic Synthesis with Light-Fluorous Reagents, Reactants, Catalysts, and 2006 39 Scavengers University of Puerto Rico Soderquist, John A. Samarium(II) Iodide in Organic Synthesis 1991 24 University of South Carolina Adams, Richard D. The Catalytic Synthesis of Thiacrowns from Thietanes and Thiiranes by Metal 2000 33 Carbonyl Complexes University of South Florida Newkome, George R.; Moorefield, Charles Building Blocks for Dendritic Macromolecules 1992 25 N.; Baker, Gregory R. University of Southampton Brown, Tom Mismatches and Mutagenic Lesions in Nucleic Acids 1995 28 University of Southampton Lebreton, S.; Monaghan, S.; Bradley, M. Solid-Phase Dendrimer Chemistry: Synthesis and Applications 2001 34 University of Southern California at Olah, George A. New Synthetic Reagents and Reactions 1979 12 Los Angeles University of St. Andrews Al-Maharik, Nawaf; O’Hagan, David Organofluorine Chemistry: Deoxyfluorination Reagents for C-F Bond Synthesis 2011 44 University of Strathclyde, Watson, Allan J. B.; Eastman, Harry E.; Development of Solvent Selection Guides 2015 48 Glasgow, U.K. Jamieson, Craig University of Sussex Cornforth, John Warcup The Trouble with Synthesis 1994 27 University of Technology Massey, A.G.; Humphries, R. E. The Direct Synthesis of Non-Transition-Metal Organo Derivatives 1989 22 (Loughborough) and U. of New Brunswick (St. John) University of Tenessee at Knoxville Kabalka, George W. Organoboranes in Organic Synthesis 1975 8 University of Tennessee at Knoxville Kabalka, George W. The Synthesis of Labeled Compounds via Organoboranes 1986 19 University of Texas at Austin Patman, Ryan L.; Bower, John F.; Kim, In Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation: 2008 41 Su; Krische, Michael J. Vinylation, Allylation and Enolate Addition University of Tokyo Shibasaki, Masakatsu; Kanai, Motomu; Chiral, Poly(Rare-Earth-Metal) Complexes in Asymmetric Catalysis 2006 39 Matsunaga, Shigeki University of Tokyo Kobayashi, Shū; Miyamura, Hiroyuki Polymer-Incarcerated Metals: Highly Reactive, Recoverable, and Multifunctional 2013 46 Nanocluster Catalysts for Organic Synthesis University of Toledo Pereira, Schubert; Srebnik, Morris The Ireland-Claisen Rearrangement 1993 26 University of Toronto Baktharaman, Sivaraj; Hili, Ryan; Yudin, Amino Carbonyl Compounds in Organic Synthesis 2008 41 Andrei K. University of Toronto Jones, J. Bryan Probing the Specificity of Synthetically Useful Enzymes 1993 26 University of Toronto and Seoul Kim, Hyunwoo; So, Soon Mog; Chin, Jik; Preparation of Chiral Diamines by the Diaza-Cope Rearrangement (DCR) 2008 41 National University Kim, B. Moon University of Utah Michel, Brian W.; Sigman, Matthew W. Peroxide-Mediated Wacker Oxidations for Organic Synthesis 2011 44 University of Utah Stang, Peter J.; White, Mitchell R. Triflic Acid and Its Derivatives 1983 16 University of Virginia Harrison, Daniel P.; Harman, W. Dean Opening New Chemical Space through Novel Dearomatization Reactions 2012 45 University of Virginia Ireland, Robert E. Synthetic Methodology in the Context of Natural Product Total Synthesis 1988 21

To Search, press CTRL+F 62 AFFILIATION Authors Title Year Vol. University of Wisconsin at Madison Landis, Clark R.; Wong, Gene W. Highly Enantioselective Hydroformylation of Alkenes by Rhodium-Diazaphospholane 2014 47 Catalysts University of Wisconsin at Madison Trost, Barry M. Transition-Metal Templates for Selectivity in Organic Synthesis 1981 14 University of Wisconsin at Madison West, Robert Squaric Acid and the Aromatic Oxocarbons 1968 1

University of Wisconsin at Madison Stahl, Shannon S.; Miles, Kelsey C. Practical Aerobic Alcohol Oxidation with Cu/Nitroxyl and Nitroxyl/NOx 2015 48 Catalyst Systems University of Wisconsin at Milwaukee Fu, Xiaoyong; Cook, James M. The Synthesis of Polyquinanes and Polyquinenes via the Weiss Reaction 1992 25

5 + University of Wisconsin at Milwaukee Redlich, Mark D.; Mayer, Michael F.; Iron Lewis Acid [(η -C5H5)Fe(CO)2(THF)] Catalyzed Organic Reactions 2003 36 Hossain, M. Mahmun U.S. Environmental Protection Agency Baig, R. B. Nasir; Nadagouda, Cyclic Sulfamidate Enabled Syntheses of Amino Acids, Peptides, Carbohydrates, and 2015 48 Mallikarjuna N.; Varma, Rajender S. Natural Products U.S. Environmental Protection Agency Varma, Rajender S. Advancing Sustainable Catalysis with Magnetite. Surface Modification and Synthetic 2016 49 Baig, R. B. Nasir; Verma, Sanny; Applications Nadagouda, Mallikarjuna N. Varian Associates Evans, C. Anderson Spin Trapping 1979 12 Warner Babcock Institute for Green Warner, John C. Where We Should Focus Green Chemistry Efforts 2015 48 Chemistry Washington University, St. Louis, MO Birman, Vladimir B. Amidine-Based Catalysts (ABCs): Design, Development, and Applications 2016 49 Wayne State University Johnson, Carl R. Applications of Sulfoximines in Synthesis 1985 18 Wayne State University Winter, Charles H. The Chemical Vapor Deposition of Metal Nitride Films Using Modern Metalorganic 2000 33 Precursors Weed Science Research Lab (USDA) Wiswesser, William J. Johann Josef Loschmidt (1821-1895): A Forgotten Genius. Benzene Rings and Much 1989 22 More in 1861 Wesleyan University Fry, Albert J. Electrochemistry in Organic Synthesis 1993 26 Yale University Herzon, Seth B.; Zeng, Mingshuo Ruthenium-Catalyzed anti-Markovnikov Hydration and Reductive Hydration of 2014 47 Terminal Alkynes Yale University Wasserman, Harry H. New Methods in the Formation of Macrocyclic Lactams and Lactones of Biological 1987 20 Interest Yale University Danishefsky, Samuel J. Reflections on Organic Synthesis: The Evolution of a General Strategy for the 1986 19 Stereoselective Construction of Polyoxygenated Natural Products Yale University Anastas, Paul T. Green Chemistry Next: Moving from Evolutionary to Revolutionary 2015 48 York University (Toronto, ON, Kantchev, Eric Assen B.; O’Brien, Pd-N-Heterocyclic Carbene (NHC) Catalysts for Cross-Coupling Reactions 2006 39 Canada) Christopher J.; Organ, Michael G. Mickel, Stuart 4-Acetoxy-2-azetidinone: A Useful Heterocyclic Synthon 1985 18 Long, John R. Lanthanides in Organic Synthesis 1985 18 Bryce, Martin R. Tetrathiafulvalenes (TTF) and their Selenium and Tellurium Analogs (TSF and TTeF): 1985 18 Electron Donors for Organic Metals

To Search, press CTRL+F 63 Painting Clues Year Vol. No. Cover Painting Artist CLUES

2013 46 1 VOL. 46, NO. 1 • 2013 Farmhouse in Vincent Van Gogh The reason for van Gogh’s fascination with the color yellow—evident in many of his paintings— Provence has been the subject of much speculation. While some believe it was due to his prolonged use of absinthe, which contains traces of thujone (see Aldrich Product Nos. 89231 and 89230), others attribute it to the treatment with digitalis (see Sigma Product Nos. D5878 or C9140) that he received for his epileptic condition. Do you believe either explanation? Let us know your thoughts on this.

Polymer-Incarcerated Metals: Highly Reactive, Recoverable, and Multifunctional Nanocluster Catalysts for Organic Synthesis

Advances in Acylation Methodologies Enabled by Oxyma-Based Reagents

46 2 VOL. 46, NO. 2 • 2013 Breezing Up Winslow Homer Artists have often incorporated various objects in their compositions as symbols of human (A Fair Wind) emotions or as commentary about the human existence or a human endeavor: a skull, a dead fish, a dove, etc. Here, it is believed that Homer depicted an anchor lying on the front and starboard side of the boat as a symbol of his hope in the future of the young country that had just emerged from a devastating civil war and that was celebrating its centennial in the year in which this painting was completed and first exhibited.

Aminoacyl Benzotriazolides: Versatile Reagents for the Preparation of Peptides and Their Mimetics and Conjugates

Recent Advances in the Prins Cyclization

46 3 VOL. 46, NO. 3 • 2013 A View of the Thomas Cole In 1826, a storm caused a rock slide at Crawford Notch that killed an entire family of nine and Mountain Pass brought national attention to the notch. The tragedy and the idyllic beauty of the surrounding area Called the Notch may have inspired Cole to paint this landscape. Cole, who subscribed to the romantic notion that of the White unspoiled nature is a reflection of God’s presence and that the destruction of virgin forests is an Mountains outrageous violation of His will, has included elements in this painting that hint at his message: (Crawford Notch) serene, breathtaking beauty of the area, human activity that is beginning to spoil this beauty, and gathering storm clouds that foreshadow the impending catastrophe.

Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry

Cross-Linked Enzyme Aggregates (CLEAs) in Organic Synthesis

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2014 47 1 VOL. 47, NO. 1 • 2014 Moonlight on the John Crome John Crome seems to have been influenced by seventeenth- and eighteenth-century Dutch and Yare English masters. It would be a useful exercise to compare Moonlight on the Yare with landscapes DEDICATED TO DR. ALFRED BADER ON THE OCCASION OF HIS 90TH BIRTHDAY by Hobbema (A View on a High Road and A Farm in the Sunlight), Gainsborough (View in Suffolk), Van der Neer (Moonlit Landscape with Bridge), Wilson (Solitude), and Rembrandt (The Mill). It would also be worthwhile to compare Moonlight on the Yare with a number of landscapes of the Norwich area by Crome’s longtime artist friend, brother-in-law, and fellow Norwich resident, Robert Ladbrooke.

Asymmetric Catalysis Using Chiral, Enantiopure Disulfonimides

Enabling Novel Photoredox Reactivity via Photocatalyst Selection

47 2 VOL. 47, NO. 2 • 2014 Lake Albano Richard Wilson A favorite setting for a number of landscape artists of the 18th and 19th centuries, actual Lake Albano is a small crater lake located in the Alban Hills a short distance southeast of Rome, Italy. In addition to Wilson, George Innes (Lake Albano, Sunset), Robert Freebairn (View of Lake Albano and Castel Gandolfo), Camille Corot (Lake Albano and Castel Gandolfo), and Joseph Wright of Derby (Lake Albano), among others, have painted different views of Lake Albano and its immediate surroundings.

Highly Enantioselective Hydroformylation of Alkenes by Rhodium-Diazaphospholane Catalysts

Boronic Acid Catalysis: an Atom-Economical Platform for Direct Activation and Functionalization of Carboxylic Acids and Alcohols

47 3 VOL. 47, NO. • 2014 Lady and Aelbert Cuyp Cuyp featured the leaves of the burdock plant prominently in a number of his paintings (Young Gentleman on Herdsmen with Cows; A Page with Two Horses; An Evening Landscape with Figures and Sheep). Horseback The leaves are believed to symbolize virtue, and an equestrian couple setting out for a hunt is thought to be an allegory for love. It may be that, in this painting, Cuyp is conveying the idea that the lady and the gentleman are newlyweds, who are embarking on their journey of life and love together.

Ruthenium-Catalyzed anti-arkovnikov Hydration and Reductive Hydration of erminal Alkynes

EP-Derived xoammonium alts as ersatile xidizing Agents

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2015 48 1 VOL. 4, NO. 1 • 201 Wivenhoe Park, John Constable Wivenhoe Park is an actual place southeast of the town of Colchester, England, and is now the Essex location of the University of Essex. When painted by Constable, it was a working, self-sustaining REE CHER E . . L E EDR country estate owned by Major-General Francis Slater Rebow, Constable’s first major patron and a friend of his father. Almost every element of the painting hints at this sustainability: the kitchen garden by the mansion, the pond and the fish, the trees and the grass, the farm animals, and the water fowls, among others.

CONTRIBUTORS TO THIS ISSUE Anastas • Constable • Gallou and Hamann • Gladysz • Jessop • Koenig • Krische • Lipshutz • Ritter • Stahl • Tucker • Warner

ADDITIONAL ONLINE CONTRIBUTORS Rogers • Sheldon

48 2 VOL. 4, NO. 2 • 201 A Royal Party Johann Georg von Dillis Hesselberg Mountain was and still is a popular sightseeing destination. It is located about Admiring the 38 miles (60 km) southwest of Nuremberg in the German state of Bavaria. According to various Sunset atop accounts, Prussian King Friedrich Wilhelm III, his wife Queen Luise zu Mecklenburg-Strelitz, and the Hesselberg their immediate entourage visited the mountain on June 10, 1803, during a tour of their Frankish Mountain, 1801 estates three years before the area was ceded to Bavaria. According to the National Gallery (NGA German Master Drawings), this highly finished drawing by von Dillis depicts this visit, and was probably commissioned by Queen Luise. This drawing, however, was finished and signed by von Dillis on May 23, 1801, two years prior to the purported visit! So, which is correct, the Catalytic Asymmetric Hydrogenation of D-Substituted Ketones and Aldehydes via Dynamic Kinetic Resolution: E
cient Approach to Chiral Alcohols SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of date the drawing was finished or the date the king visited the mountain? We welcome your input Saturated N-Heterocycles Development of Solvent Selection Guides and comments!

48 3 VOL. 4, NO. • 201 Tamaca Palms, Frederic Edwin Church One is struck by the similarities in the scenes of later compositions by Church; such as View of 1854 Cotopaxi (1857), Heart of the Andes (1859), and Tropical Scenery (1873). Could Church have used sketches he made in one locale to enhance scenes depicting other locales? What do you think?

Ynamides: Powerful and Versatile Reagents for Chemical Synthesis

Cyclic Sulfamidate Enabled Syntheses of Amino Acids, Peptides, Carbohydrates, and Natural Products

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2016 49 1 VOL. 4, NO. 1 • 201 En route pour la John Singer Sargent En route pour la pêche and Fishing for Oysters at Cancale are almost the same painting: the pêche, 1878 same vantage point, beach, women and children in the foreground, and the same lighthouse and fishing port in the background. However, the work in the Museum of Fine Arts appears less refined and less complete, with missing elements such as the basket carried by the boy in the foreground and the additional townsfolk coming down the slipway in the background. Also, the fishing port area is not as sharply in focus, the sky less bright, and the composition darker overall. Can you identify additional discrepancies between the two compositions?

Nucleophilic Chiral Phosphines: Powerful and Versatile Catalysts for Asymmetric Annulations

Silanediol Recognition in Catalysis, Sensing, and Drug Discovery

49 2 VOL. 4, NO. 2 • 201 Giant Magnolias on Martin Johnson Heade Cattleya Orchid and Three Brazilian Hummingbirds (oil on wood panel, 34.8 × 45.6 cm) was a Blue Velvet Cloth, painted by Heade in 1871 following his trip to Central America. The painting was featured on the ca. 1890 cover of Aldrichimica Acta, Vol. 35, No. 3 (2002). It proved to be one of the most popular Acta cover paintings with readers. Heade painted several variations on the theme of hummingbirds and tropical flowers, as well as still lifes of magnolias. These are found in various art museums and galleries as well as in private hands. Perhaps, the best place to view images of them online would be martin-johnson-heade.org.

Amidine-Based Catalysts (ABCs): Design, Development, and Applications

Advancing Sustainable Catalysis with Magnetite. Surface Modi cation and Synthetic Applications

49 3 VOL. 4, NO. • 201 Young Woman with Frédéric Bazille Frédéric Bazille painted Young Woman with Peonies (oil on canvas, 60 × 75 cm; at the National Peonies, 1870 Gallery of Art, Washington, DC) and La Négresse aux pivoines (oil on canvas, 60.5 × 75.4 cm; at the Musée Fabre, Montpellier, France) in the summer of 1870, just a few short months before he died. The woman depicted in these two paintings appears to be the same, wearing the same headscarf and the same white dress, and one can only wonder about her relationship to Bazille. Was she a real person, perhaps a flower vendor on the same street where Bazille worked or lived, or was she a creation of Bazille based on some work by another artist? Perhaps a knowledgeable reader could shed some light on who she was. Photocatalytic C–F Reduction and Functionalization

Recent Enabling Technologies for Diazomethane Generation and Reactions Longtime readers of the Aldrichimica Acta may be familiar with Bazille’s work, as we have featured another of his fine compositions from 1867, The Ramparts at Aigues-Mortes, on the cover of an earlier issue. Check out the painting commentary in that issue (Aldrichimica Acta, Vol. 38, No. 2, 2005) to learn more about Bazille, his creativity, and his contribution to the early development of Impressionism.

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2017 50 1 VOLUME 50, NO. 1 | 2017 Alte Apotheke im Unknown Alte Apotheke im Museum der Firma Merck (watercolor and ink, 38.5 × 49.5 cm) was painted ALDRICHIMICA Museum der Firma by an unknown artist in Darmstadt, Germany. It depicts original components of the Merck family’s ACTA Merck Engel-Apotheke (Engel Pharmacy), such as the pharmacy table within a niche of the company museum. Beneath a cross-ridge vault, the pharmacy is set up as was typical for the early 1800s, stocked with various vessels and grinding implements. A stuffed alligator, an Egyptian symbol against illness, hangs from the ceiling. The scene transports the viewer back in time to an era when apothecarists combined raw animal, plant, and mineral substances to create drugs. After Friedrich Jacob Merck’s acquisition of the Engel Pharmacy in 1668, generations of pharmacists 4-Substituted Prolines: Useful Reagents in Enantioselective HIMIC IC A R A Synthesis and Conformational Restraints in the Design of D C L T Bioactive Peptidomimetics A A Recent Advances in Alkene Metathesis for Natural Product

Synthesis—Striking Achievements Resulting from Increased strove to refine the pharmaceutical craft into an independent academic discipline. Emmanuel Merck Sophistication in Catalyst Design and Synthesis Strategy

The e scece sess o erc a, arsa, era operaes as poreSa he S a aaa (1794–1855) is generally credited with setting the foundation for his family’s pharmacy to grow into a chemical company in the first half of the 19th century. Emmanuel Merck’s early research on alkaloids led him to connect with others and seek out pure products rather than raw materials. This painting is part of the collection housed at the company museum located at our Darmstadt, Germany, headquarters, where the Engel Pharmacy work tables are still on display: www.emdgroup.com/history. 50 2 Nymphenburg Bernardo Bellotto Bellotto’s many panoramic views of Dresden and Warsaw that depicted in rich detail not only Palace, Munich, (1722–1780) important buildings and sections of these two cities, but also daily life in them, proved invaluable ca. 1761 in the effort to rebuild them following their near-total destruction during World War II. To stress this point, Nymphenburg Palace is today a popular tourist destination in Munich, and, amazingly, still looks much the same way it is depicted in Bellotto’s painting from over 250 years ago!

50 3 VOLUME 50, NO. 3 | 2017 City Hall at Thorn, Eduard Gaertner To appreciate how amazingly exact Gaertner’s cityscapes generally are, compare the view ALDRICHIMICA 1848 (1801–1877) of City Hall at Thorn (Prussia) that he painted in 1848 with a recent photograph of the same ACTA view of the town hall in the city of Toruń (now in Poland). It is as if time has stopped between 1848 and 2017! A photo of the present-day Old City Town Hall can be viewed at https://www. dreamstime.com/editorial-image-gothic-town-hall-old-town-torun-poland-february-listed- unesco-organisation-image55065205 or at http://www.rgbstock.com/photo/mhXYRU0/ Medieval+town+hall+in+Torun

HIMIC IC A R A D C L T Palladium-Catalyzed meta- and para-C–H Bond A A Functionalizations Assisted by a Directing Group

The e scece sess o erc a, arsa, era operaes as poreSa he S a aaa

To Search, press CTRL+F 68 Year Vol. No. Cover Painting Artist CLUES 2018 51 1 Ginevra de’ Benci, Leonardo da Vinci On the back, or reverse, side of this panel is another painting, Wreath of Laurel, Palm, and Juniper [obverse] (1452–1519) with a Scroll. On the scroll, the Latin inscription reads “Virtutem Forma Decorat”, or Beauty 1474/1478 Decorates Virtue. This is clearly in reference to the subject of the portrait on the obverse side, and serves as its symbol. At the center of the emblem is a juniper branch, a symbol of chastity in Italy at the time, and a stand-in for Ginevra herself. The juniper is surrounded on each side by a palm and a laurel branch, representing moral virtue and literary talents, both known attributes of Ginevra. Thus, the back side is another symbolic portrait of Ginevra. To read more about the two sides of this masterpiece, and about who is likely to have commissioned it, check out the NGA’s website at nga.gov.

51 2 River Landscape, “Velvet” Brueghel, aka Brueghel the Elder’s breadth of artistic interests and abilities is rarely found in a single artist. He 1607 Jan Brueghel the Elder ranged from flower and animal paintings (check out his painting Two Squirrels that graced the (1568–1625) cover of Aldrichimica Acta 42.1, 2009), to various types of landscape and garland paintings, as well as several other genres. He excelled in all, which earned him several nicknames: “Velvet” Brueghel, “Flower” Brueghel, and “Paradise” Brueghel. His landscapes often included common themes that Brueghel employed to state and reinforce societal, political, or religious messages or commentaries. For example, compare his paintings River Bank at the Indianapolis Museum of Art or Figures Dancing on the Bank of a River with the one featured on the cover of this issue of the Aldrichimica Acta. In this regard, could the motif of the dead fish in the lower left-hand corner of River Landscape represent the ephemeral nature of life and the need to lead one’s life wisely and virtuously? 51 3 On Their Way to (Jonathan) Eastman A few years back we featured another fine genre painting, The Brown Family, by Johnson, this Camp, 1873 Johnson (1824–1906) time of an indoor, tranquil family scene. Eastman Johnson was a well-known and much-sought- after artist in his lifetime. His work and reputation allowed him to become a member of the National Academy of Design at a fairly young age. He was also quite active in many artistic circles and organizations. Foremost, however, is his enduring legacy as a co-founder, on April 13, 1870, of the prestigious Metropolitan Museum of Art (“The Met”) in New York City.

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2019 52 1 VOLUME 52, NO. 1 | 2019 — — Dr. Alfred Robert Bader—co-founder of Aldrich Chemical Co. and Sigma-Aldrich Corp. (today a part ALDRICHIMICA of Merck KGaA, Darmstadt, Germany) and one of the most influential men in the chemical industry ACTA since the mid-twentieth century—passed away peacefully on December 23, 2018, at the age of 94. Dr. Bader founded and launched the Aldrichimica Acta in 1968. For about the first 24 years of its existence, the Acta cover featured paintings from Dr. Bader’s private collection, and he often wrote the “About Our Cover” commentary about the featured painting. A Harvard chemistry graduate,

Dr. Alfred Bader 1924–2018 Alfred was also a renowned art connoisseur and avid art collector, who acquired the nickname The

Chemist Collector. Until the end, Dr. Bader was a most enthusiastic supporter of, and advocate Remembering Dr. Alfred R. Bader (1924–2018)

Phenothiazines, Dihydrophenazines, and Phenoxazines: Sustainable Alternatives to Precious-Metal-Based Photoredox Catalysts Titanium Salalen Catalysts for the Asymmetric Epoxidation of for, the Acta: He believed strongly in its value, eagerly anticipated each issue, requested copies of Terminal (and Other Unactivated) Olefins with Hydrogen Peroxide

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada. each, and distributed them to his visitors. He promoted the Acta wherever he went and whenever he could. He will be missed. 52 2 The Square of Saint Giovanni Antonio Canal Canaletto painted Saint Mark’s Square several times from many directions. These compositions of Mark’s, Venice, (1697–1768) actual views share many elements with the current painting. See, for example, the one at the Arp 1742/1744 Museum Bahnhof Rolandseck or the one at the Harvard Art Museums. Canaletto often painted these “vedute” directly outside the studio, and intended them to be purchased as souvenirs by tourists and other visitors of Venice. Canaletto also created fanciful compositions called “capriccios”, such as Capriccio: An Island in the Lagoon with a Pavilion and a Church (St. Louis Art Museum), which we featured on the cover of Aldrichimica Acta 1992, 25 (3). Partly as a result of Canaletto’s work and fame, Venice became a destination and subject for later generations of artists such as John Singer Sargent (Aldrichimica Acta 2000, 33 (3)), Richard Parkes Bonington (Aldrichimica Acta 2010, 43 (1)), and Joseph Mallord William Turner (Aldrichimica Acta 2012, 45 (1)). Canaletto’s influence is also seen in the work of his equally renowned pupil and nephew, Bernardo Belloto, whose landscape painting Nymphenburg Palace, Munich, was also featured on the cover of a recent issue of the Aldrichimica Acta 2017, 50 (2).

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