INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE Tw elfth Scientific Meeting and Exhibition 15-21 MAY 2004

VOL. 10, NUMBER 3 NOVEMBER 2003

2 The Meeting, and the Message from the Local and Regional Organizing Committee I 3 Call for Papers, Information for Authors, New Features for 2004, and Hosting Region Poster Presentations N 4 Preliminary Program of the ISMRM 12th Scientific Meeting & Exhibition 16 Educational Stipends for Students and Postdoctoral Trainees S 17 Clinical Resident Stipend Program I 18 New Entrant Stipend Program D 19 E.K. Zavoisky Stipend Program E 20 SMRT Update 21 ISMRM Workshop Report on Cellular and Molecular Imaging in Diagnostics and Therapy 22 Upcoming ISMRM Workshop on MR in Drug Development: From Discovery to Clinical Therapeutic Trials KYOTO INTERNATIONAL CONFERENCE HALL 23 Upcoming ISMRM Workshop on Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective KYOTO, JAPAN 24 ISMRM Dates and Deadlines

Letter From The President

ongratulations to Professors Paul Lauterbur and Peter Mansfield on winning C the 2003 Nobel Prize in Physiology or Medicine!

The Nobel Assembly at Karolinska Institutet on Monday, 6 October 2003, awarded the Nobel Prize in Physiology or Medicine for 2003 jointly to Drs. Paul C. Lauterbur and Sir Peter Mansfield for their discoveries concerning magnetic resonance imaging. The Nobel Academy notes that the two have made “seminal discoveries concerning the use of magnetic resonance to visualize different structures. These discoveries have led to the development of modern magnetic resonance imaging, MRI, which represents a breakthrough in medical diagnostics and research.” (http://www.nobel.se/medicine/laureates/2003/press.html) Sir Peter Mansfield Paul C. Lauterbur This is of course the occasion that many of us have been waiting years for; the well-deserved recognition of the pioneering efforts that these two have made that has affected everything that we all do within the sphere of Magnetic Resonance. I know that I speak for all of us in saying that we are very happy that their work has finally been acknowledged with this Prize. It provides the public recognition that MR has deserved in significantly improved diagnostic imaging in many diseases for many disciplines. This award builds on the earlier Nobel Prizes given to the fundamental discoveries of the magnetic moments (Rabi, 1944), the NMR phenomenon (Purcell and Bloch, 1952), the implementation of 2D MR spectroscopy (Ernst, 1991), the development of MR spectroscopy for 3D macromolecular structures (Wüthrich, 2002), and now for MRI. In one interview this week, Paul Lauterbur is quoted as saying, “In particular, I believe, I think the work has been helpful to many people…” This is indeed an understatement. The understanding of the spatial localization of the MR signal is the key to everything we do in MR. During the Lauterbur Lecture at the 2002 ISMRM Annual Meeting in Honolulu, this was made apparent in a moving and dramatic presentation by Paul to our membership.

See President’s Letter page 2 President’s Letter THE MEETING from page 2

Beyond the recognition of this fact by The Twelfth Scientific Meeting and Exhibition of the International Society for Magnetic the Nobel Academy, we should also be aware Resonance in Medicine will take place 15-21 May 2004 at the Kyoto International Conference and grateful for the contributions that Drs. Hall in Kyoto, Japan. The program for the ISMRM Scientific Meeting will be available online Lauterbur and Mansfield have made to the through the ISMRM Website (www.ismrm.org). Please call the ISMRM office for more Society; both are past Gold Medal Winners information or e-mail [email protected]. and both are Society Past-Presidents. To pay tribute, we hope to have video interviews with Paul and Sir Peter, as well as the 2002 Message from the Local and Regional Organizing Committee Lauterbur Lecture, available for general n behalf of the Local and Regional Organizing Committees of the 12th International viewing during the upcoming 2004 ISMRM Society for Magnetic Resonance in Medicine, I would like to welcome all of you to Annual Meeting in Kyoto. Expect further this premier International Meeting in Magnetic Resonance in Medicine, which will be tributes and Nobel celebrations being O held from May 15 to 21, 2004, at the Kyoto International Conference Hall in Kyoto, Japan. planned for the Kyoto Meeting. The ISMRM Annual Meeting will take place for the first time in an Asian country in 2004. Besides the excitement of the Nobel It is indeed my great pleasure to welcome all the scientists, radiologists, and technologists announcements, the Board of Trustees is from all over the world to Kyoto to attend the 12th ISMRM. I would like to express my planning another web-based “Zoomerang” sincere appreciation to all of you for your interest and support of this meeting. survey of our members, with the goal of The 12th ISMRM will highlight the most recent advances in Magnetic Resonance in obtaining information to further assist Medicine and place emphasis on recently developing imaging techniques and diagnosis. with future meeting and strategic planning. The objectives of ISMRM will be not only to share medical knowledge and experience in One common theme of the survey will be Magnetic Resonance in Medicine, but also to develop closer ties among researchers and that of communication with and within the clinicians from various countries. membership. In response to the last survey one year ago and to implement more Since we host this meeting in Asia, we would like to organize several programs which frequent informal communications with the are unique in Asia. Special seminars and presentations will be planned in addition to the membership, our Past President, Dick Ehman, usual scientific program for participants from Japan as well as from Asia. There will be the Board of Trustees, together with the two social events with a Japanese flavor to promote friendship and fellowship among ISMRM Central Office is now making available participants and acquaint them with traditional Japanese culture. They include the a “Question-and-Answer” (Q&A) section on opening reception and the gala party. the ISMRM Website to explain committee structure, study groups, society awards, and Kyoto is an ancient capital of Japan and has a lot to offer in regard to traditional general information within the Society. Look Japanese culture, rich historical heritage, and beautiful scenery with many interesting for this within the month. The Society has sightseeing spots. also been active in recent months in helping I do hope you will enjoy not only the scientific part of the meeting but also the inform the EU public regarding the “Directive beautiful scenery of Kyoto and the history of Japan. For The Protection Of Workers From Exposure To Electro-Magnetic Fields And Waves (EMF).” Mutsumasa Takahashi, M.D. In response to many such efforts on the part Chair, Local and Regional Organizing Committee of our sister societies such as the ESMRMB, the EU have just released this statement on LOCAL ORGANIZING COMMITTEE 2004 the progress of negotiations: “Static Magnetic Fields (and implications for MRI) have been Mutsumasa Takahashi, M.D., Chairperson Hiroo Ikehira, M.D. (Japan) removed from the exposure limit values….” Atsuko Heshiki, M.D., Vice Chairperson Tamon Inoue, Ph.D. (Japan) This in essence means that there are now no Kazuo Miyasaka, M.D., Secretary General Toshiro Inubushi, Ph.D. (Japan) plans on the part of the EU to limit exposure Kuni Otomo, M.D., Treasurer Masumi Kadoya, M.D. (Japan) to static magnetic fields in the short term. Kazuro Sugimura, M.D., Treasurer Yoko Kanazawa, Ph.D. (Japan) We within the ISMRM want to thank Dr. Shoji Naruse, M.D., Treasurer Katsumi Kose, Ph.D. (Japan) Penny Gowland at Nottingham University, Tokuko Watanabe, Ph.D., Secretary Lilian L.Y. Leong, M.B., B.S., F.R.C.R. (Hong Kong) UK, Dr. Marty Prince, and the ISMRM Safety Fumiyuki Mitsumori, Ph.D. (Japan) Committee for their efforts to help bring this Tsutomu Araki, M.D. (Japan) Carolyn E. Mountford, D.Phil. (Australia) about. Sudarshan K. Aggarwal (India) Tsutomu Nakada, M.D. (Japan) Kee-Hyun Chang, M.D. (Korea) Lenny Tan (Singapore) Clearly, it is a momentous time for Jian-Ping Dai, M.D. (China) Kaori Togashi, M.D. (Japan) our Society. Please join me and the Board Tsukasa Doi (Japan) Shogo Ueno, Ph.D. (Japan) of Trustees in congratulating Drs. Lauterbur Wan-Yuo Guo, (Taiwan, R.O.C.) Masahiro Umeda, Ph.D. (Japan) and Mansfield for their recognition by the Hiroto Hatabu, M.D. (Japan) Tsuneya Watabe, M.D. (Japan) Nobel Academy! Junichi Hachiya, M.D. (Japan) Hiroshi Watari, M.D. (Japan) Kazuhiro Homma, Ph.D. (Japan) Yasuyuki Yamashita, M.D. (Japan) — Michael E. Moseley, ISMRM President

2 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 CALL FOR PAPERS INFORMATION FOR AUTHORS

The Scientific Program Committee invites NEW THIS YEAR! abstract submissions to be presented in oral sessions, as conventional posters, and Poster Presentation Options as electronic posters at the ISMRM Twelfth Scientific Meeting & Exhibition. If you wish to have your abstract considered Submissions must contain new, previously for poster presentation, you will be able to unpublished material. All abstracts must be choose between two presentation options: submitted electronically via the ISMRM 1. Traditional poster presentation. Your Website. No paper forms will be available. abstract will be published in the Proceedings, Any abstract submitted on paper will not and your poster will be presented in the be considered for review. The deadline for poster hall. You will stand at your poster receipt of abstracts is 19 November 2003. during your assigned poster session to answer Poster Presentation A 100-word synopsis of each abstract will be questions and discuss your work with printed in the Program Book. It should of MR Sites from the colleagues. include a brief description of the problem, Hosting Region methods, results, and conclusions. It must 2. Electronic poster presentation. Your include text only, with no equations or abstract will be published in the Proceedings. SUBCOMMITTEE ON MR SITE PRESENTATIONS images and no references or citations to You will also be asked to submit your poster items described in the full abstract. If the in PowerPoint format in advance of the Atsuko Heshiki, M.D., Chair submitted synopsis is longer than 100 words, meeting, and a CD containing all electronic Kee-Hyun Chang, M.D., Jeffrey L. Duerk, it will be cut short in the Program Book. posters will be published and distributed to Ph.D., Hiroyuki Fujita, Ph.D., Albert C. To conserve space and provide authors meeting registrants. Because the posters will Lardo, Ph.D., Cynthia L. Lean, Ph.D., greater opportunity to clarify their projects, be available electronically, inclusion of Kazuro Sugimura, M.D., Kaori Togashi, M.D. the synopsis should NOT appear in the movies, sounds, and other multi-media In addition to the submission of traditional actual abstract submission (previously it formats is possible. This new format opens abstracts, MR sites in Japan, China, and the was the first paragraph). The abstract should new opportunities for poster presentation, Pan Pacific region are kindly invited to be submitted in a single-column format, and authors are encouraged to take advantage present their sites and research projects in a according to the instructions found online. of them. No formal presentation of electronic special poster area, which should give an You will be able to compose your abstract posters will be made. overview of all the MR activities in this and then upload it for submission. Detailed A number of on-site E-poster review stations region. The whole series of posters will instructions for submission are posted on will be available as well as a number of emphasize the clinical and scientific work the ISMRM Website. All copyrights to E-poster Discussion Kiosks with LCD/beamer going on in the part of the world that hosts accepted abstracts become the property of projection to facilitate discussion. As the 2004 ISMRM Scientific Meeting. This ISMRM. No proprietary information may be already done with the abstracts, copyrights poster section should become a gathering withheld by authors. to accepted electronic posters become the place for all scientists and clinicians, not You may also receive submission information property of ISMRM. only from the hosting region but also from by calling, faxing, or writing to: abroad and should therefore facilitate International Society for Magnetic Resonance ABSTRACT SUBMISSIONS in Medicine, 2118 Milvia Street, Suite 201, contacts among them. Berkeley, California 94704, USA Only online submissions will be accepted. One poster will be accepted per research Telephone: +1 510 841 1899 Log on to the ISMRM Website group. It should present an overview of the Fax: +1 510 841 2340 (www.ismrm.org/04). Click on “Online clinical and research activities of an MR E-mail: [email protected] Abstract Submission” and follow the Website: www.ismrm.org group and may introduce staff members, instructions. technical equipment, lists of projects, The Proceedings will be published on ABSTRACT SUBMISSION WITHDRAWAL publication lists, and other issues relevant CD-ROM only. The full text of all accepted to scientific and clinical work. Applications Written requests for withdrawal of Abstract abstracts will be available online two weeks should be made by letter outlining the submissions from the scientific program, before the meeting to pre-registered scope of the anticipated poster presentation signed by the first author, must be received attendees only. If you wish to have access and must be received by 17 November 2003. to the Proceedings before the meeting, you by 20 January 2004 at the ISMRM Central must pre-register. Office. WHERE TO APPLY LETTERS OF NOTIFICATION International Society for Magnetic Resonance in Medicine Authors will be notified of the decision of Subcommittee on Site Presentations the Scientific Program Committee in Scientific Program Committee February 2004. 2118 Milvia Street, Suite 201 Berkeley, California 94704, USA

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 3 Preliminary Program WEEKEND EDUCATIONAL PROGRAMS

BRAIN FUNCTION AND fMRI IMPORTANT DATES 17 NOVEMBER 2003 Peter Jezzard, Douglas C. Noll, and Deadline for online receipt of Hosting Region Poster submissions. Steve C.R. Williams, Organizers 19 NOVEMBER 2003 Saturday, 15 May, 08.30 - 17.50 and Deadline for online receipt of Abstract Sunday, 16 May, 08.10 - 14.40 submissions. EDUCATIONAL OBJECTIVES 19 NOVEMBER 2003 Upon completion of the course, participants Deadline for receipt of Student Stipend Applications. should be able to: Identify the principal areas of the brain 19 NOVEMBER 2003 used in sensory perception, motor Deadline for receipt of E.K. Zavoisky Stipend Applications. activity, language, and cognition; Describe the way in which these cortical 30 JANUARY 2004 areas inter-communicate, both at the Deadline for receipt of Clinical Resident Stipend Applications. electrical and chemical level; Describe the associated hemodynamic 30 JANUARY 2004 responses of the brain that accompany Deadline for receipt of New Entrant Stipend Applications. electrical and metabolic activity; Define and compare the various MRI pulse sequences that can be used to map human brain function; Identify the sources of artifacts that are inherent in many fMRI procedures and describe methods to minimize these artifacts; Design a simple fMRI paradigm, and describe the principles used in data analysis; Explain the principles of perfusion based fMRI and the methods used to construct maps of white matter tracts; Identify the areas of application of fMRI in neurology, psychiatry and basic neuroscience. PROGRAM The final five minutes of each presentation will be reserved for questions. Day 1: Saturday, 15 May 08.30 Introduction SESSION I: Functional Anatomy and Connectivity 08.40 Introduction to Neuronal Anatomy and Electrical Activity Mark S. Cohen 09.15 Grey Matter Functional Specialization Arno Villringer 09.50 Fiber Tracts and Structural Connectivity in the Human Brain Hubertus Axer 10.25 Break

SESSION II: Neurochemistry 10.45 Neurochemistry and Neuro- transmitter Systems Paul Grasby 11.20 Neuronal Metabolism Stephen R. Williams 11.55 Hemodynamic Responses to Neuronal Activity Richard B. Buxton 12.30 Break

4 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program WEEKEND EDUCATIONAL PROGRAMS

SESSION III: The BOLD Signal MR PHYSICS FOR PHYSICISTS SESSION III: From Signal to Image: 14.00 Sources of BOLD Signal and Field Michael H. Buonocore, Peter M. Jakob, and Basic Concepts Strength Issues John P. Mugler, Organizers 14.10 Pulse Sequences I: Echo Formation Richard P. Kennan R. Todd Constable 14.35 Temporal BOLD Characteristics and Saturday, 15 May, 08.30 - 17.50 and 14.50 Pulse Sequences II: Spatial Non-Linearity Sunday, 16 May, 07.30 - 14.30 Encoding and Image Douglas C. Noll Reconstruction 15.10 Spatial Resolution Limits EDUCATIONAL OBJECTIVES Richard G.S. Spencer Robert W. Cox Upon completion of the course, participants 15.30 Break 15.45 Break should be able to: Describe the fundamental properties of 15.50 Pulse Sequences III: Major SESSION IV: fMRI Pulse Sequences and the NMR signal, spin polarization, and Techniques Artifacts different quantum mechanical interac- Klaus Scheffler 16.05 BOLD fMRI Sequences tions of spins; 16.30 Measurement and Optimization of Peter Jezzard Explain physical principles, signal Image Quality 16.40 Susceptibility Artifacts processing techniques, and instrumenta- Dennis L. Parker Lawrence L. Wald tion used in signal creation, detection, 17.15 Minimization and Correction and image generation; SESSION IV: From Signal to Image: of Physiological Noise Components Compare and contrast the structure, Advanced Concepts in fMRI advantages and unique image artifacts of 17.10 Models for Magnetization Behavior Gunnar Krueger routinely-used advanced pulse sequences; Jürgen Hennig 17.50 Adjournment Describe measurements for characterizing 17.50 Adjournment and optimizing image quality, and Day 2: Sunday, 16 May methods for avoidance of image artifacts; Day 2: Sunday, 16 May SESSION V: Experimental Design and Data Describe models and graphical tools for SESSION IV: From Signal to Image: Analysis understanding magnetization dynamics, Advanced Concepts (continued) 08.10 Experimental Paradigm Design and separating out the components of 07.30 Image Reconstruction Via Gridding Nick F. Ramsey magnetization contributing to an MR Gary H. Glover 08.45 Pre-Statistics echo. 08.10 Image Reconstruction from Mark Jenkinson Compare advanced image reconstruction Limited Data 09.10 Data Modeling, the General Linear methods based on gridding, and those Zhi-Pei Liang Model, and Statistical Inference used in parallel imaging. 08.50 Parallel Imaging: The Basics Robert W. Cox Peter Kellman Explain special MRI pulse sequences and 09.55 Break 09.30 Break processing methods used for spatial mapping of specific physiological SESSION VI: Non-BOLD Functional Imaging 09.50 Parallel Imaging: Toward Routine processes. Methods Clinical Use 10.15 Functional Perfusion MRI PROGRAM David J. Larkman Thomas T. Liu The final five minutes of each presentation 10.30 Image Artifacts and Correction 10.50 Connectivity Mapping Using DTI will be reserved for questions. Methods Derek K. Jones Day 1: Saturday, 15 May Joseph V. Hajnal 11.10 Questions SESSION I: Origin and Basic Properties of 11.10 RF Pulse Design 11.30 Break the MR Signal John Pauly 08.30 Quantum-Mechanical and Classical 11.50 Break SESSION VII: Clinical and Neuroscience Description of the MR Signal Applications James Tropp SESSION V: From Images to Physiological 13.00 Design of a Clinical fMRI Protocol 09.10 Multiple-Quantum Coherence: Mapping Steve C.R. Williams Theory and Application 13.10 Phase Contrast Techniques for 13.25 fMRI of Neurological Disorders Jianhui Zhong Measuring Velocity and Flow Steven C. Cramer 09.50 Beyond Thermal Polarization Norbert J. Pelc 13.50 fMRI of Drug Abuse Gordon Cates 13.50 Measuring Water Diffusion in Thomas Ernst 10.30 Break Tissue 14.15 fMRI of Human Sensory Processes Peter van Zijl and High-Level Cognition SESSION II: The MRI System 14.30 Adjournment Kang Cheng 10.50 Overview of an MRI System 14.40 Adjournment Richard W. Bowtell 11.30 Transmit and Receive RF Subsystems Ed B. Boskamp 12.10 Break 13.30 Gradient Subsystem Franz Schmitt

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 5 Preliminary Program WEEKEND EDUCATIONAL PROGRAMS

ADVANCED BODY MRI NEUROIMAGING 15.50 Clinical Application and Safety of Donald G. Mitchell and Richard Semelka, Yukio Miki and William T.C. Yuh, Organizers Contrast Agents Organizers Michael V. Knopp Saturday, 15 May, 08.30 - 17.00 16.10 Imaging Based Radiation Treatment Saturday, 15 May, 08:30 - 17:15 Nina A. Mayr EDUCATIONAL OBJECTIVES 16.30 Clinical Application from Low to 3T Upon completion of the course, participants EDUCATIONAL OBJECTIVES Scanners Upon completion of the course, participants should be able to: Lawrence N. Tanenbaum should be able to: Describe and implement in daily clinical 16.50 Open Discussion Evaluate and recommend pulse sequence practice several of the newest and most 17.00 Degenerative Diseases of the Spine strategies that will optimize body MR promising MR techniques; Douglas P. Beall imaging and MR angiography; Compare new knowledge to current 17.20 Infectious Diseases of the Spine Describe cost-effective indications for MR practice, recognizing the strengths and E. Turgut Tali imaging throughout the body; weaknesses in their own practice; 17.40 Spinal Cord Tumors and Their Evaluate new pulse sequences based on Identify MR areas that potentially benefit Mimics existing knowledge of MRI techniques, clinical practice and patient management; Yuichi Inoue allowing continuous improvement of body Describe the current status of high-field 18.00 Open Discussion MRI and MRA protocols; neuroimaging; 18.30 Adjournment Implement modern MR applications for Explain the role of various MR techniques diagnosing chest, abdominal, pelvic and in the diagnosis of diseases of the spine, vascular diseases; and head and neck in both adults and RF BOOTCAMP: Incorporate into their practices recent pediatric patients. ESSENTIALS OF RF COIL DESIGN, developments for MR imaging of the CONSTRUCTION, AND INTERFACE pancreas and biliary tract, including MR H. Cecil Charles and Michael B. Smith, cholangiopancreatography, and for PROGRAM Organizers comprehensive evaluation of the kidneys; 08.30 Review and Update of MR Physics and Protocols Saturday, 15 May, 08.00 - 17.50 Diagnose abdominal vascular disease Stephen R. Thomas using state-of-the-art MR angiographic 08.50 Diffusion Imaging EDUCATIONAL OBJECTIVES techniques; Upon completion of the course, participants (Including Tensor) should be able to: Identify new diagnostic opportunities in Susumu Mori MR body imaging. 09.10 Perfusion Imaging Define inductance, capacitance, resonance Kei Yamada and distributed capacitance with reference PROGRAM 09.30 Spectroscopy and Brain Activation to RF coils, their design and operation; 08.30 Body MRI Techniques William G. Bradley Describe the basic needs and components Donald G. Mitchell 09.50 Open Discussion of a working RF laboratory; 09.15 3T MRI– Role for Body Imaging? 10.00 Break Compare design and construction of two Shahid M. Hussain important types of coils; 10.30 Sellar and Parasellar Diseases 09.45 Screening of the Abdomen with MRI Yukio Miki Explain the fundamentals of RF coil Susanne C. Goehde connections to the scanner. 10.15 Break 10.50 MRA and CTA Shigeki Aoki PROGRAM 10.30 Diffuse Liver Disease 11.10 Diagnosis and Intervention of Acute Stroke 08.00 Welcome and Overview Katsuyoshi Ito H. Cecil Charles 11.00 Hepatocellular Carcinoma William Yuh, Masayuki Maeda, and Toshiaki Taoka 08.10 Basic Concepts I (Components) Masa Kanematsu Steven M. Wright 11.30 MRI Contrast Agents 11.40 Open Discussion 11.50 Break 08.40 Basic Concepts II (Measurements) Myeong-Jin Kim James R. MacFall 12.15 Pancreas 13.30 Brain Tumors 09.10 The RF Laboratory Richard Semelka Yukunori Korogi Randy Duensing 12.45 Break 13.50 MR Imaging of Seizure Disorder 10.00 Discussion 14.15 MRA of the Abdomen Kee-Hyun Chang Team Guenther Schneider 14.10 Infectious Diseases of the Brain 10.20 Break Fong Y. Tsai 15.00 Acute Disease of the Female Pelvis 10.40 The Flat Circular Coil (Theory) Michele Brown 14.30 Inflammatory Diseases of the Brain Vincent Dousset H. Cecil Charles 15.30 Prostate 11.10 The Flat Circular Coil (Construction) Jelle O. Barentsz 14.50 Open Discussion 15.00 Break H. Cecil Charles 16.00 Break 12.00 Break 16.15 Bowel 15.30 Head and Neck Diego R. Martin Thomas Vogl 16.45 Chest MRI Hiroto Hatabu 17.15 Adjournment

6 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program WEEKEND EDUCATIONAL PROGRAMS

13.30 The Bird Cage Coil (Theory) Applications MR SPECTROSCOPY: FRONTIER Michael B. Smith 13.45 Clinical MRS: Tumors and Masses in METHODOLOGY AND APPLICATIONS 14.15 The Bird Cage Coil (Construction) the Brain Roland Kreis, Organizer H. Cecil Charles Franklyn A. Howe 15.00 Coil Interface: Theory and 14.15 Clinical MRS: Tumors and Masses in Sunday, 16 May, 07.30 - 14.30 Implementation the Prostate and Breast Randy Duensing John Kurhanewicz EDUCATIONAL OBJECTIVES 15.45 Break 14.45 Clinical MRS: MS and Inflammation Upon completion of the course, participants should be able to: David H. Miller 16.05 Where do We Go From Here? 15.15 Discussion Describe fundamental principles on which Michael B. Smith 15.30 Meet the Teacher Break advanced uses of MRS are based; 16.45 Safety Issues List state-of-the-art techniques developed Daniel J. Schaefer 16.00 Clinical MRS: Stroke and Hypoxia for research applications of MR spectro- 17.30 Panel Discussion Peter B. Barker scopy; Team 16.30 Clinical MRS: Epilepsy 17.50 Adjournment Appraise potential and hurdles for the use Kenneth D. Laxer of new ways of polarization transfer in 17.00 Clinical MRS: Psychiatry in vivo MRS; MR SPECTROSCOPY: Perry F. Renshaw Summarize recent biomedical research 17.30 Discussion activities involving in vivo MRS; BASICS AND CLINICAL APPLICATIONS 17.45 Meet the Teacher Roland Kreis, Organizer Summarize issues of present-day method- 18.00 Adjournment ology and applications of high resolution Saturday, 15 May, 08.30 - 18.00 spectroscopy.

EDUCATIONAL OBJECTIVES Upon completion of the course, participants PROGRAM should be able to: The final eight minutes of each presentation will be reserved for questions. Describe fundamental principles of clinical MR spectroscopy; Methodology 07.30 Sophisticated RF Pulses for MRS Explain the crucial steps in performing Robin A. de Graaf and evaluating a MRS examination; 08.00 (De-)Coupling and Spectral Editing Enumerate potential pitfalls in the Peter S. Allen clinical application of MR spectroscopy; 08.30 Fast CSI Define diagnostic and patient manage- Stefan Posse ment situations in which there is a 09.00 New Ways for Polarization Transfer clinically significant justification for a Jan Henrik Ardenkjaer-Larsen MRS examination; 09.40 Meet the Teacher Break Summarize recent clinical uses of in vivo 10.10 High Resolution NMR MRS. Masahiro Shirakawa

PROGRAM Advanced Applications The final five minutes of each presentation will 10.50 In Vitro NMR Approaches to be reserved for questions. Metabonomics and Metabolomics Introduction and Methodology Jeremy K. Nicholson 08.30 Basics of MRS 11.30 Meet the Teacher Break Chris Boesch 12.45 High Field 1H-MRS 09.00 Localization Techniques Rolf Gruetter Markus von Kienlin 13.15 In Vivo 13C and 15N MRS and 09.30 Prescan and Shimming Kinetic Analyses Daniel M. Spielman Douglas L. Rothman 10.00 Discussion 13.45 23Na MR: How and Why 10.15 Meet the Teacher Break Gil Navon 14.15 Meet the Teacher 10.45 Detectable Metabolites and Their 14.30 Adjournment Significance Robert J. Gillies 11.15 Data Processing + Fitting Andrew A. Maudsley 11.45 Quantitation + Artifacts in Clinical MRS Roland Kreis 12.15 Discussion 12.30 Meet the Teacher Break

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 7 Preliminary Program WEEKEND EDUCATIONAL PROGRAMS

CARDIAC IMAGING MR OF TRANSGENIC MOUSE MODELS MUSCULOSKELETAL MRI David A. Bluemke, Organizer (MR OMICS) Lynne S. Steinbach, Organizer Daniel H. Turnbull, Organizer Sunday, 16 May, 07.30 - 17.00 Sunday, 16 May, 07.30 - 17.00 Sunday, 16 May, 08.00 - 16.30 EDUCATIONAL OBJECTIVES EDUCATIONAL OBJECTIVES Upon completion of the course, participants EDUCATIONAL OBJECTIVES Upon completion of the course, participants should be able to: The course will give an understanding of the should be able to: Explain the use of cardiac MR to assess following topics: Identify various principles of physics that myocardial ischemia and viability; Different ways in which molecular result in some of the more popular MR List the current recognized indications in biologists are using mouse models to imaging sequences; cardiovascular imaging as well as to understand development and disease; Design optimized protocols in musculo- define those under investigation; Small animal imaging; skeletal MRI; Interpret CMR examinations of cardio- Applications of MR to mouse models of Interpret normal anatomy of the ankle myopathy and ARVD; cancer, neurological and cardiac diseases; tendons and ligaments, knee ligaments, Describe the current value of MR imaging Use of MR and mouse models for drug hip, wrist, shoulder and elbow; of the coronary arteries and atheroscle- discovery; different approaches being Recognize pathology of the ankle tendons rotic plaques and list its limitations; taken to obtain functional and molecular and ligaments, knee ligaments, hip, wrist, Describe analysis methods used in CMR. information from mouse imaging shoulder and elbow using MRI; techniques. Distinguish some patterns of benign PROGRAM lesions that can be mistaken for The final five minutes of each presentation will PROGRAM neoplastic lesions on MR. be reserved for questions. 08.00 Mouse Models of Human Disease 07.30 Coronary MR Angiography Alexandra L. Joyner PROGRAM Matthias Stuber 08.45 Overview of Mouse Imaging 07.30 Technical Aspects of 08.05 MRI of Atherosclerotic Disease Methods Musculoskeletal MRI Chun Yuan R. Mark Henkelman Christopher F. Beaulieu 08.40 MRI of Congenital Heart Disease 09.30 Break 08.15 MRI of Ankle Tendons and Scott D. Flamm Ligaments 09.15 Break 10.00 MR of Mouse Models of Lynne S. Steinbach Neurological Disease 09.00 MRI of the Knee: Ligaments 09.35 MR Dobutamine Stress Testing Daniel H. Turnbull Garry E. Gold Raymond Kwong 10.45 MR of Mouse Models of Cancer 09.45 Questions 10.10 MR Perfusion Imaging of Ischemia Zaver M. Bhujwalla 09.50 Break Steven D. Wolff 11.30 Break 10.45 MRI of Myocardial Viability 10.10 MRI of the Hip Andrew Arai 13.00 MR of Mouse Models of Cardiac Juerg Hodler 11.20 Questions/Summary Disease 10.55 MRI of the Wrist 11.30 Break Axel Haase Mark Schweitzer 13.45 MR of Mouse Models for Drug 11.45 Questions 13.00 Analysis of Cardiac MR Images Discovery 11.50 Break Rob van der Geest Nicolau Beckmann 13.35 MRI in Assessment of Arrhythmia 14.30 Break 13.20 MRI of the Shoulder: David A. Bluemke Impingement and Rotator Cuff 14.05 LV Global and Regional Function 15.00 Functional MR Imaging and William B. Morrison Victor A. Ferrari Spectroscopy in Mice 14.05 MRI of the Shoulder: Instability 14.40 Break Mathias Hoehn Wilfred C.G. Peh 15.45 Cellular/Molecular MR Imaging 14.50 Questions 15.00 Clinical Cardiac Imaging at 1.5T in Mice 14.55 Break and 3.0T: Relative Strengths and Jeff W.M. Bulte Weaknesses 16.30 Adjournment 15.15 MRI of the Elbow J. Paul Finn Christine Chung 15.35 Non-Contrast CMR Approaches in 16.00 Musculoskeletal Pseudotumors on Coronary Heart Disease MRI Matthias Friedrich Suzanne E. Anderson 16.10 Interventional CMR 16.45 Questions Harald Quick 17.00 Adjournment 16.45 Questions/Summary 17.00 Adjournment

8 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program PLENARY SESSIONS

Opening Session Monday, 17 May, 09.00 - 10.15 Tuesday, 18 May, 08.15 - 09.30 Monday, 17 May MR IMPACT IN METABOLOMICS MRI BEYOND TISSUE ANATOMY AND PROTEOMICS WITH NOVEL CONTRAST AGENTS Welcome & Awards Ceremony 07.45 - 08.20 Sebastián Cerdán and Rolf Gruetter, Organizers Sebastián Cerdán, Organizer EDUCATIONAL OBJECTIVES EDUCATIONAL OBJECTIVES 2004 LAUTERBUR LECTURE: Upon completion of this session, participants Upon completion of this session, participants “From Immune Suppression should be able to: should be able to: Explain the concepts of metabolomics and Briefly describe the principles of contrast to Mad Cow Disease– proteomics, and their potential relevance agent design, and the different in medicine; approaches for imaging tissue pH, p0 and In Vitro NMR Spectroscopy 2 Describe the roles of metabolomics in other biochemical variables; with the Molecules of Life” tumor diagnosis, drug discovery and drug Explain approaches for improved blood Kurt Wüthrich, Eidgenössische Technische evaluation; pool imaging and its applications in Hochschule, Zurich, Switzerland Describe the role that MRI can and has angiography and vascular research; 08.20 - 09.00 played in the modern view of proteomics Give examples of applications of stem and metabolomics. cells in physiology and pathology and Dr. Wüthrich was awarded the Nobel Prize describe approaches for stem cell tracking in 2002 for his development of nuclear PROGRAM by MRI. magnetic resonance spectroscopy for 09.00 From the Genome to the PROGRAM determining the three-dimensional structure Metabolome by NMR of biological macromolecules in solution. Kevin Brindle 8.15 MRI of Biochemical Variables with Through his work at the beginning of the University of Cambridge Novel Contrast Agents 1980s, Kurt Wüthrich has made it possible Cambridge, England, UK A. Dean Sherry to use NMR on proteins. He developed a University of Texas general method of systematically assigning 09.25 The Tumour Metabolome by Dallas, Texas, USA 1 certain fixed points in the protein molecule H MRS: Implications for 08.40 Improved Blood Pool Agents for and also a principle for determining the Medical Diagnosis John R. Griffiths High Resolution Angiography and distances between these. Using the St. George’s Hospital Medical School Vascular Research distances, he was able to calculate the London, England, UK Robert M. Weisskoff three-dimensional structure of the protein. EPIX Medical, Inc. The advantage of NMR is that proteins can 09.50 MR-based Metabonomic Cambridge, Massachusetts, USA be studied in solution, i.e., an environment Approaches in Toxicology, similar to that in the living cell. His work in Disease Diagnosis and Global 09.05 Stem Cell Tracking in Physiology NMR is also used in the pharmaceutical Systems Biology and Pathology industry to determine the structure, and Jeremy K. Nicholson Mathias Hoehn hence the properties, of proteins and other Imperial College Faculty of Medicine Max Planck Institute for macromolecules that can be interesting London, England, UK Neurological Research target molecules for new pharmaceuticals. Cologne, Germany Pharmaceutical molecules are designed to fit into the structure of the protein– like a key in a lock. Perhaps the most important industrial use of NMR is in the search for small potential pharmaceutical molecules that can interact with a given biological macromolecule. If the small molecule binds to the large one, the NMR spectrum of the large molecule is normally changed. This may be used to “screen” a large number of pharmaceutical candidates at an early stage in the development of a new drug.

Adapted from the Official Website of the Nobel Foundation

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 9 Preliminary Program PLENARY SESSIONS

Wednesday, 19 May, 08.15 - 09.30 Thursday, 20 May, 08.15 - 09.30 Friday, 21 May, 08.15 - 09.30 MR IN SCREENING THE CURRENT AND FUTURE EXTENDING THE LIMITS OF MRI: Riccardo Manfredi, James F.M. Meaney and ROLE OF IMAGING IN CANCER NEW CONCEPTS FOR SIGNAL Neil M. Rofsky, Organizers THERAPY ASSESSMENT DETECTION AND ENHANCEMENT EDUCATIONAL OBJECTIVES Kim Butts and Jeffrey L. Duerk, Organizers Michael B. Smith, Daniel K. Sodickson, and Upon completion of this session, participants Scott D. Swanson, Organizers should be able to: EDUCATIONAL OBJECTIVES Upon completion of this session, participants EDUCATIONAL OBJECTIVES Compare the various screening tests, in should be able to: Upon completion of this session, participants the light of the current knowledge base should be able to: (accuracy, cost, availability, etc); Describe several areas in which clinical oncologists could effectively use non- Identify new methods of detecting small List areas where MRI is likely to be invasive assessment of cancer therapy; signals in NMR and appreciate why superior to other competing modalities; List the ways in which MR is currently different technologies are required for Describe the potential of MRI for screen- used in assessing cancer therapy (either different spatial scales; ing, specifically in cardiovascular disease efficacy, progression, side-effects, Describe current and new uses of laser and cancer; prognosis, etc.); polarized noble gases; Evaluate recent research into new Discuss the challenges screening poses to Assess future directions of novel tech- polarization-enhanced contrast agents the MR community. niques and agents that will be developed created with Dynamic Nuclear Polarization by or available to the MR community to (DNP) or ParaHydrogen-Induced Polariza- assess cancer therapy. PROGRAM tion (PHIP), and identify their potential 08.15 Disease Screening in the impact for direct imaging of enhanced PROGRAM 21st Century: molecules; Is it Viable and What are the 08.15 The Role of Imaging in the Appreciate how fundamental NMR Tools? Assessment of Cancer Treatment research translates into future clinical Bruce J. Hillman Anthony F. Shields procedures and creates new windows into University of Virginia Health Wayne State University the molecular world of man. Sciences Center Detroit, Michigan, USA Charlottesville, Virginia, USA PROGRAM 08.40 Current Concepts in MR Based 08.15 Signal Detection in NMR: 08.40 MR Screening in Cardiovascular Therapy Assessment Macroscopic, Microscopic and Disease Michael V. Knopp Nanoscale Zahi A. Fayad Ohio State University James Tropp Mount Sinai School of Medicine Columbus, Ohio, USA General Electric Medical Systems New York, New York, USA Fremont, California, USA 09.05 Molecular Imaging in Cancer 09.05 MR Screening in Cancer Therapies of the Future 08.40 NMR and MRI at a Distance: Christiane K. Kuhl Chrit T. Moonen From Nanometers to Meters University of Bonn Université Victor Segalen Alexander Pines Bonn, Germany Bordeaux, France University of California Berkeley, California, USA

09.05 Beyond Relaxation Contrast: Agents for Polarization Enhancement in MR Imaging J. Stefan Petersson Amersham Health Malmö, Sweden

10 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program MORNING CATEGORICAL COURSES Tuesday, 18 May - Friday 21 May, 07.00 - 08.00 FUNCTIONAL BODY MRI: UNDERSTANDING DIFFUSION ECHO MANAGEMENT FROM MORPHOLOGY TO FUNCTION TENSOR IMAGING AND FUNCTIONAL Kim Butts and Scott D. Swanson, Organizers Riccardo Manfredi and Carlo Bartolozzi, MRI: THE RELATIONSHIP BETWEEN Organizers STRUCTURE AND FUNCTION EDUCATIONAL OBJECTIVES Upon completion of this course, participants EDUCATIONAL OBJECTIVES IN THE BRAIN Gareth J. Barker and R. Todd Constable, should be able to: Upon completion of this course, participants should be able to: Organizers Explain the basic principles of spin echo, gradient echo, and stimulated echo Evaluate new pulse sequences based on EDUCATIONAL OBJECTIVES formation; knowledge of current MR technique, Upon completion of this course, participants Appreciate the complexity of coherence allowing continuous improvement of body should be able to: MR images; pathways that arise when two or more RF Explain how the fMRI data is acquired and pulses are applied; Incorporate recent developments for MR processed; Describe methods that investigators use imaging such as MRCP for the pancreas and biliary tract, and MR diffusion and Explain how the diffusion tensor is to mitigate effects of multiple coherence perfusion techniques for kidneys; acquired, measured and mapped; pathways to assure formation of proper echoes; Define the terms structural and functional Apply new contrast agents in different hepatic diseases; connectivity; List techniques used in steady-state free precession (SSFP) pulse sequences to Evaluate the possibility of MR imaging in Describe sources of artifacts, limitations to the data, and the likely impact of new minimize spurious echo formation; bowel imaging and in screening oncologic patients for metastatic disease; parallel imaging techniques on fMRI and Determine which sequence will be DTI data; appropriate for what clinical application. Achieve functional information reflecting physiologic processes. Outline the methods available to combine the complementary information from PROGRAM fMRI and DTI data. Tuesday, 18 May PROGRAM 07.00 Basic Principles of Echo Formation Tuesday, 18 May PROGRAM R. Scott Hinks 07.00 Perfusion and Diffusion Techniques The final five minutes of each presentation 07.25 Basics of Echo Formation: Refocused in Body Imaging will be reserved for questions. James B. Murdoch Joseph C. McGowan Tuesday, 18 May 07.50 Discussion 07.30 Body Imaging at 3T Introduction to fMRI Kimberly Amrami 07.00 fMRI Basics: Paradigm Wednesday, 19 May Design/Analysis 07.00 Basic FSE/TSE and FLARE Wednesday, 19 May R. Todd Constable David G. Norris 07.00 Liver and Liver-Specific Contrast 07.30 fMRI Resting State Connectivity/ 07.25 Advanced FSE/TSE Agents Structural Equation Modeling Jürgen Hennig Thomas Helmberger Mark J. Lowe 07.50 Discussion 07.30 Biliary and Pancreatic Ducts Alice Gillams Wednesday, 19 May Thursday, 20 May Introduction to DTI 07.00 Gradient Recalled Echoes Thursday, 20 May 07.00 DTI Basics Felix W. Wehrli 07.00 Kidneys Derek K. Jones 07.25 Advanced Gradient Echo Imaging Michael Pedersen 07.30 Tractography and Beyond Samuel Patz 07.20 Uterus/Female Pelvis Geoff Parker 07.50 Discussion Kaori Togashi 07.40 Whole Body MRI Thursday, 20 May Friday, 21 May Thomas Lauenstein Artifacts… and Correction Strategies 07.00 Fully Refocused SSFP 07.00 DTI Klaus Scheffler Friday, 21 May Christopher A. Clark 07.25 Setting Up the steady State in SSFP 07.00 Bowel 07.30 fMRI Brian A. Hargreaves David J. Lomas Douglas C. Noll 07.50 Discussion 07.30 Breast Francesco Sardanelli Friday, 21 May Quantitative Measures/Information Obtained 07.00 DTI: b-Values, Fractional Anisotropy and Other Quantitative Measures Peter J. Basser 07.30 fMRI/DTI - Combining Data Claudia A.M. Wheeler-Kingshott

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 11 Preliminary Program MORNING CATEGORICAL COURSES

Tuesday, 18 May - Friday 21 May, 07.00 - 08.00 ESTABLISHED AND EVOLVING NEW HORIZONS IN Friday, 21 May APPLICATIONS OF MRA MUSCULOSKELETAL MRI: 07.00 Spatial Resolution and SNR James F.M. Meaney, Organizer OPTIMIZING MR IMAGING WITH Considerations in MRI of the CURRENT TECHNOLOGY Musculoskeletal System EDUCATIONAL OBJECTIVES Joshua M. Farber and Lawrence M. White, Garry E. Gold Upon completion of this course, participants 07.25 Optimizing Clinical Protocols in should be able to: Organizers MRI of the Musculoskeletal System Define the established indications for EDUCATIONAL OBJECTIVES William B. Morrison MRA; Upon completion of this course, participants 07.50 Discussion Recognize the importance of non-contrast should be able to: and contrast-enhanced approaches in the Describe MR techniques for imaging different vascular territories; cartilage at various field strengths and PARALLEL IMAGING 2004 Diagnose common vascular pathology and understand the clinical role of MRI in the Neil M. Rofsky and Daniel K. Sodickson, evaluation of articular cartilage disorders; variants; Organizers Apply the different post-processing Assess the musculoskeletal system using algorithms to enhance diagnostic high- and low-field MR systems; EDUCATIONAL OBJECTIVES practice; Explain use of fat suppression MRI Upon completion of this course, participants Perform basic vessel wall imaging. techniques in the musculoskeletal system; should be able to: Explain and use fast scanning MRI Explain the basic principles of parallel PROGRAM techniques in the musculoskeletal system; imaging, including elements both of Tuesday, 18 May RF coil array design and of image Understand high-resolution MR imaging reconstruction; Body MRA and its trade-off with signal to noise, and 07.00 Thoracic Aorta MRA apply this knowledge to imaging the Critically survey promising clinical Mitsue Miyazaki musculoskeletal system; applications of parallel MRI; 07.20 Abdominal MRA Describe the rationale of protocol Summarize current research into the Thomas M. Grist approaches and apply this understanding limits of performance of parallel imaging, 07.40 Coronary MRA to optimize MRI clinical protocols. describe new developments in image Scott D. Flamm reconstruction and coil array design, and outline emerging parallel imaging PROGRAM applications; Wednesday, 19 May Tuesday, 18 May MRA Post-processing Workstation 07.00 MRI of Cartilage– Identify the key steps in a practical Technical Considerations parallel imaging examination, and compare Demonstrations– Speakers to be announced the nuts-and-bolts features of various MR Timothy J. Mosher 07.00 Philips Medical Systems vendors’ existing implementations. 07.10 GE Medical Systems 07.25 MRI of Cartilage– Clinical Applications and Imaging 07.20 Siemens Medical Solutions PROGRAM 07.30 Vital Images Evaluation Tuesday, 18 May 07.40 Toshiba Carl S. Winalski Basics 07.50 Panel Discussion 07.50 Discussion 07.00 Introduction Daniel K. Sodickson Thursday, 20 May Wednesday, 19 May 07.05 Coil Arrays Peripheral MRA 07.00 Fat Suppression Techniques in (The Technological Tools) 07.00 Upper Extremity MRA Musculoskeletal MRI Michael Ohliger Klaus U. Wentz John A. Carrino 07.30 Image Reconstruction 07.20 Lower Extremity MRA 07.25 Fast Imaging Techniques in (The Mathematical Tools) Tim Leiner Musculoskeletal MRI Klaas Prüssmann 07.40 MR Venography Joshua M. Farber 07.55 Discussion Stefan G. Ruehm 07.50 Discussion Wednesday, 19 May Friday, 21 May Thursday, 20 May Clinical Applications Carotid MRA 07.00 High Field MRI of the Musculo- 07.00 Recap of Basics 07.00 Optimization of Non-contrast skeletal System: Techniques, Daniel K. Sodickson Techniques Protocol Optimization and Clinical 07.05 Applications in Clinical Cardiology Dennis L. Parker Applications Scott D. Flamm 07.20 Contrast-Enhanced MRA Johannes Bloem 07.30 Applications in Clinical Radiology John Huston 07.25 Mid-Low Field MRI of the Musculo- Stefan O. Schoenberg 07.40 Plaque Imaging and Characterization skeletal System: Techniques, 07.55 Discussion Chun Yuan Protocol Optimization and Clinical Applications Hiroshi Yoshioka 07.50 Discussion

12 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program MORNING CATEGORICAL COURSES

Tuesday, 18 May - Friday 21 May, 07.00 - 08.00 Thursday, 20 May SPECTROSCOPY: Thursday, 20 May Current Research THE BRAIN AND BEYOND 07.00 Using Water as an Internal 07.00 Recap of Basics and Applications Peter S. Allen, John R. Griffiths, and Rolf Standard Daniel K. Sodickson Gruetter, Organizers Dieter Leibfritz 07.05 Limits of Parallel MRI: Recent 07.20 Discussion Results, Current Controversies EDUCATIONAL OBJECTIVES 07.30 Dealing with Macromolecular Daniel K. Sodickson Upon completion of this course, participants Signals 07.20 New Developments in Image should be able to: Kevin L. Behar Reconstruction Describe the principles of spectral analysis 07.50 Discussion Jeffrey Tsao through LC modeling; 07.40 New Developments in Array Design Friday, 21 May Outline the mechanisms for intra-sequence Jozef H. Duyn 07.00 In Vivo Measurement of Muscle signal loss when target metabolites have and Liver Glycogen Friday, 21 May coupled spins; Peter G. Morris Vendor Update 2004 List the key metabolites facilitating the 07.20 Discussion 07.00 Recap of Basics, Applications, and spectroscopic recognition of tumor 07.30 Myo-cellular Lipid Measurements New Developments development in the prostate and the Chris Boesch Daniel K. Sodickson brain; 07.50 Discussion 07.05 Philips Medical Systems Outline how water can be used as an Johan van den Brink internal concentration standard with 07.15 GE Medical Systems minimal associated spectral artifacts; Kevin F. King 07.25 Siemens Medical Solutions Explain how macromolecular contamina- Berthold Kiefer tion of spectra can be recognized and 07.35 Toshiba mitigated; Tetsuhiko Takahashi Explain how MRS can be used to reflect 07.45 Hitachi metabolic processes in muscle using Kazuya Okamoto glycogen or lipids. 07.55 Discussion and Conclusion

PROGRAM Tuesday, 18 May 07.00 The LC Modeling Approach Pierre-Gilles Henry 07.20 Discussion 07.30 Coupled-Spin-Metabolite Signal Yield Peter S. Allen 07.50 Discussion

Wednesday, 19 May 07.00 MRS in Cancer of the Prostate Daniel Vigneron 07.20 Discussion 07.30 MRS and Brain Cancer Martin O. Leach 07.50 Discussion

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 13 Preliminary Program CLINICAL CATEGORICAL COURSES

IMAGING IN DRUG DEVELOPMENT INTERVENTIONAL MRI: HOT TOPICS FOR CLINICAL PRACTICE Jeffrey L. Evelhoch and John R. Griffiths, THE STATE OF THE ART AND BEYOND Thomas M. Grist and Clifford R. Jack, Organizers Kim Butts, Organizer Organizers Monday, 17 May, 11:00 - 13:00 Tuesday, 18 May, 10.30 - 12.30 Wednesday, 19 May 10.30 - 12.30 EDUCATIONAL OBJECTIVES EDUCATIONAL OBJECTIVES EDUCATIONAL OBJECTIVES Upon completion of this course, participants Upon completion of this course, participants Upon completion of this course, participants should be able to: should be able to: should be able to: Explain why the pharmaceutical industry List several procedures that are being Describe five points that can be used to is incorporating imaging into the process developed under MRI guidance; improve imaging strategies in important areas of clinical practice; of drug development; Describe the types of MR-compatible List at least two examples of how devices and open MRI systems that are Assess the applicability to clinical practice information provided from MR studies can available; of three newer imaging techniques. impact the developmentof a drug; Describe some of the challenges of using PROGRAM Describe what roles a practicing radiolo- MRI guidance for interventional procedures; Wednesday, 19 May gist should play in imaging studies Compare the value of MRI-guidance to This course covers the most current questions associated with clinical trials of new other available image-guidance systems. and controversial areas, and includes the drugs. most up-to-date information available. PROGRAM Therefore, the final selection of subjects and PROGRAM Tuesday, 18 May speakers for the Hot Topics Course is not Monday, 17 May 10.30 MR-Guided Breast Biopsy made until a date much later than for the Drug Development in Oncology Christiane K. Kuhl other courses at the meeting, and at this 11.00 The Role of MR and Radiologists 10.50 MR-Guided Focused Ultrasound time we don’t yet have details. Please check Patricia Cole Kullervo Hynynen the website periodically for news of the 11.15 Current and Future MR Methods 11.10 MR-Guided Microwave Therapy of course program. Geoff J.M. Parker the Liver 11.30 A Radiologist’s Perspective Shigehiro Morikawa Frederick Kelcz 11.30 MR-Guided Neurosurgery 11.45 Panel Discussion Christoph Nimsky 11.50 MR-Guided Vascular Interventions Drug Development in Osteoarthritis Elliot R. McVeigh 12.00 The Role of MR and Radiologists 12.10 Discussion John C. Waterton 12.30 Adjournment 12.15 Current and Future MR Methods Garry E. Gold 12.30 Semiquantitative and Quantitative Imaging Techniques for Drug Discovery and Development in OA: A Radiologist’s Perspective Philipp Lang 12.45 Panel Discussion 13.00 Adjournment

14 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Preliminary Program OTHER PRACTICAL COURSES

CARDIOVASCULAR MR: JAPANESE LANGUAGE SUMMARY MR PHYSICS AND TECHNIQUES TODAY AND BEYOND SESSIONS: FOR CLINICIANS Zahi A. Fayad, Christopher Kramer, and BASIC SCIENCE HIGHLIGHTS Frank R. Korosec and Joseph G. McGowan, Samuel Wickline, Organizers NEW CLINICAL DEVELOPMENTS Organizers Shoji Naruse and Kazuro Sugimura, Organizers Thursday, 20 May, 10:30 - 12:30 Monday, 17 May, 16.30 - 18.30, Monday, 17 May, 18.30 - 20.00 Tuesday, 18 May - Thursday, 20 May, EDUCATIONAL OBJECTIVES Tuesday, 18 May, 18.00 - 19.30 16.00 - 18.00 Upon completion of this course, participants should be able to: Wednesday, 18 May, 18.00 - 19.30 EDUCATIONAL OBJECTIVES Daily summary of topics and highlights of Upon completion of this course, participants Describe basic areas of routine and should be able to: promising clinical use of MR in assessing the Basic Science Sessions and the Clinical Define and describe the fundamental cardiovascular disease; Science Sessions will be presented in Japanese. principles of MR imaging, including the Apply MR protocols for determination of definition of spin magnetization, the cardiac morphology, dynamic function, Larmor relationship, relaxation phenomena, flow, and physiologic status; and the process of using the spin Explain methodology that aids in the SMRT and ISMRM Joint Presentation: magnetization to produce an image; interpretation of results for cardiac MR MANAGING MR ARTIFACTS AND Explain imaging pulse sequences based assessment of acquired cardiac disease; PITFALLS upon spin and gradient echoes, including Kim Butts and John Christopher, Organizers fast spin echo and echo planar techniques; Compare approaches for optimal presenta- tion and analysis of cardiac MR results. Monday, 17 May, 14.00 - 16.00 Design MR imaging protocols for diagnostic applications considering image contrast, EDUCATIONAL OBJECTIVES spatial resolution, acquisition time, PROGRAM Upon completion of this course, participants signal-to-noise ratio, and artifacts; Thursday, 20 May should be able to: 10.30 Valvular Disease Describe the principles and capabilities Samuel A. Wickline Recognize and identify common MR of various advanced MR techniques 10.55 Perfusion artifacts; including perfusion, diffusion, cardiac Juerg Schwitter Describe the physical causes of many and functional MRI and spectroscopy. 11.20 Viability common MR artifacts; PROGRAM Joao A.C. Lima Describe how these artifacts hinder 11.45 Coronary Lumen and Vessel Wall Monday, 17 May clinical interpretation of MR images; 16.30 Spin Gymnastics I Zahi A. Fayad 12.10 Discussion Recommend imaging solutions to prevent Walter Kucharczyk and Donald B. Plewes 12.30 Adjournment artifacts in MR images. 17.30 Spin Gymnastics II Walter Kucharczyk and Donald B. Plewes PROGRAM 18.30 Adjournment Monday, 17 May 13.30 MRI Artifacts: Tuesday, 18 May A Technical Perspective 16.00 Spin Echo Imaging Gregory C. Brown Bruce Pike 13.55 The Physics of Cardiac and Blood 16.40 Gradient Echo Imaging Flow Artifacts Michael Markl David N. Firmin 17.20 Fast Spin Echo Imaging 14.20 Neuro and Vascular Pitfalls Joseph C. McGowan William G. Bradley 18.00 Adjournment 14.45 Body and Cardiac Pitfalls Wednesday, 19 May Katsuyoshi Ito 16.00 Imaging Features 15.10 Discussion Frank R. Korosec 15.30 Adjournment 16.40 Ultrafast Imaging Marcus Alley 17.20 Diffusion Imaging Konstantinos Arfanakis 18.00 Adjournment

Thursday, 20 May 16.00 Vascular Imaging Matt A. Bernstein 16.40 Cardiac Imaging Debiao Li 17.20 fMRI James J. Pekar 18.00 Adjournment

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 15 FOR OFFICE USE ONLY Educational Stipends for Students and Postdoctoral Trainees CONFIRMATION NO. DATE RECEIVED Student Stipend Check Sheet The ISMRM invites applications for educational stipends that offer support for the attendance of students, postdoctoral and clinical SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO: trainees to present abstracts at the Twelfth Scientific Meeting. Joseph V. Hajnal, Ph.D., Chair To be eligible for support, an applicant should either be International Society for Magnetic Resonance in Medicine (1) enrolled in a full-time under-graduate or graduate program or ...... Subcommittee on Student Stipends (2) a medical intern, first-, second-, or third-year resident, or a 2118 Milvia Street, Suite 201 Berkeley, California 94704, USA postdoctoral trainee who received a doctorate or equivalent degree after 31 July 2000. Those applicants who are first authors on the abstract will be given priority. Recipients of educational Applicant Name ______Family Name Given/First Name stipends who are not members of ISMRM will be required to submit an application for membership before the funds are disbursed. Degree______Stipend recipients are limited to three years of support. Institution ______

APPLICATION PROCEDURE: Mailing Address ______Applicants for support should submit the following: Printout of the electronically submitted abstract; ______ Copy of email confirming online submission; City ______ A letter from the applicant requesting student/postdoctoral support and confirming his/her intention to attend the State/Province______meeting; Country ______ A curriculum vitae of the applicant; A supervisor’s or sponsor’s letter confirming the applicant’s Postal Code/Zip+4 ______eligibility for a student stipend. The Committee requests that the letter include comments on available funds for support. Contact Phone Number ______If a number of applicants from the same group are applying, the Committee would appreciate a unique comment on each Home Phone Number ______applicant, since funding might be limited in this situation; E-mail Address ______ Completed check sheet. Supervisor ______WHERE TO APPLY: I have previously applied for a student stipend. □ YES □ NO Joseph V. Hajnal, Ph.D., Chair International Society for Magnetic Resonance in Medicine If yes, state the year(s) you have received support ______Subcommittee on Student Stipends 2118 Milvia Street, Suite 201 ______Berkeley, California 94704, USA Have you submitted an Abstract to the ISMRM as the first author? □ YES □ NO DEADLINE: Applications must be received no later than 19 November 2003. What is the typical lowest airfare from your city to Kyoto? (US$) ______□ DO NOT release my CV to corporate sponsors. Recipients of Student Stipends will be required to submit an applica- tion for membership in the ISMRM before the funds are disbursed.

ENCLOSED: □ Student’s Application Letter □ Student’s Curriculum Vitae □ Abstract and confirmation of online submission □ Supervisor’s Letter □ Eligibility Verification □ Membership Application (for nonmembers only)

...... 16 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 FOR OFFICE USE ONLY

Clinical Resident Stipend Award ID NO. DATE RECEIVED Clinical Resident Stipend Check Sheet Recognizing the need to involve greater numbers of newly trained physicians in the science and clinical application of magnetic resonance, SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO: this stipend award has been set up to encourage young clinicians in this Joseph V. Hajnal, Ph.D., Chair field of study. Each awardee will receive US$600 toward the costs of

...... International Society for Magnetic Resonance in Medicine attending the Twelfth Scientific Meeting in Kyoto, Japan. Upon request, Clinical Resident Stipend Committee an awardee may be paired with a senior member of the ISMRM who will 2118 Milvia Street, Suite 201 be the awardee’s mentor during the Scientific Meeting, providing the Berkeley, California 94704, USA opportunity for regular reviews and discussions of important scientific and clinical developments presented at the meeting. Recipients of Applicant Name ______stipends who are not members of ISMRM will be required to submit an Family Name Given/First Name application for membership before funds are disbursed. Degree______

ELIGIBILITY CRITERIA: Mailing Address ______ Applicants must be actively enrolled in a clinical residency (i.e., clinical training) program; ______ Applicants cannot be first or presenting authors on abstracts submitted to the ISMRM program and do not need to submit an City ______abstract to the meeting; Applicants are required to attend at least 4 days of the ISMRM State/Province ______meeting, including at least one day of the weekend educational course. Country ______

PROGRAM DESCRIPTION: Postal Code/Zip+4 ______ The opportunity to be paired with a clinical mentor from the ISMRM community, with whom they will meet on a regular basis, will be Contact Phone Number ______available to stipend recipients. Mentors will subsequently be available to the awardees for advice Home Phone Number ______and discussion regarding scientific and career issues in the field of magnetic resonance. E-mail Address ______

Supervisor ______APPLICATION PROCEDURE: Applicants should send a letter including a brief statement of their interest in attending the Scientific Meeting and explaining why they □ th are interested in the field of magnetic resonance. Please pair me with a mentor for the ISMRM 12 Scientific Meeting. A letter of support from the Department Chair is required stating that the resident either will be given the time off from clinical ENCLOSED: duties to attend and be supported for the remaining cost of the □ Clinical Resident’s Application Letter meeting or will use vacation time and personal funds as needed. □ Clinical Resident’s Curriculum Vitae A curriculum vitae of the applicant must accompany the application. □ Department Chair’s Letter Completed check sheet. □ Eligibility Verification □ Membership Application (for nonmembers only) WHERE TO APPLY: Recipients of Clinical Resident stipends will be required to submit an Joseph V. Hajnal, Ph.D., Chair application for membership in the ISMRM before the funds are International Society for Magnetic Resonance in Medicine disbursed. Clinical Resident Stipend Committee 2118 Milvia Street, Suite 201 Berkeley, California 94704, USA

DEADLINE: Applications must be received no later than 30 January 2004.

...... MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 17 FOR OFFICE USE ONLY

New Entrant Stipend Award ID NO. DATE RECEIVED New Entrant Stipend Check Sheet To encourage new entrants to research in areas of interest to the ISMRM, the Society invites applications for a New Entrant Stipend Award. SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO: This program is aimed at students or researchers who are new to the Joseph V. Hajnal, Ph.D., Chair field and might not be funded under the main educational stipend ...... International Society for Magnetic Resonance in Medicine program. Each awardee will receive US$400 toward the costs of attending New Entrant Stipend Committee the Twelfth Scientific Meeting in Kyoto, Japan. Upon request, an 2118 Milvia Street, Suite 201 awardee may be paired with a senior member of the ISMRM who will be Berkeley, California 94704, USA the awardee’s mentor during the Scientific Meeting, providing the opportunity for reviews and discussions of important scientific and Applicant Name ______clinical developments presented at the meeting. Recipients of stipends Family Name Given/First Name who are not members of ISMRM will be required to submit an application Degree______for membership before funds are disbursed. Institution ______ELIGIBILITY CRITERIA: Applicants must already be or about to be actively involved in some Mailing Address ______aspect of research related to the ISMRM; Applicants cannot be first or presenting authors on abstracts ______submitted to the ISMRM program and do not need to submit an abstract to the meeting; City ______ Applicants are required to attend at least 4 days of the ISMRM meeting, including at least one day of the weekend educational State/Province ______course. Country ______PROGRAM DESCRIPTION: The opportunity to be paired with a mentor from the ISMRM Postal Code/Zip+4 ______community, with whom they will meet on a regular basis, will be available to stipend recipients. Contact Phone Number ______ Mentors will subsequently be available to the awardees for advice and discussion regarding scientific and career issues in the field of Home Phone Number ______magnetic resonance. E-mail Address ______APPLICATION PROCEDURE: Applicants should send a letter including a brief statement of their Supervisor ______interest in attending the Scientific Meeting and explain how this will □ Please pair me with a mentor for the ISMRM 12th Scientific Meeting. relate to their own work. A letter of support from the Department Chair is required stating ENCLOSED: that the student either will be given the time off to attend and be supported for the remaining cost of the meeting or will use vacation □ New Entrant’s Application Letter time and personal funds as needed. □ New Entrant’s Curriculum Vitae A curriculum vitae must accompany the application. □ Department Chair’s Letter □ Completed check sheet. Eligibility Verification □ Membership Application (for nonmembers only)

WHERE TO APPLY: Recipients of clinical New Entrant stipends will be required to submit Joseph V. Hajnal, Ph.D., Chair an application for membership in the ISMRM before the funds are International Society for Magnetic Resonance in Medicine disbursed. New Entrant Stipend Committee 2118 Milvia Street, Suite 201 Berkeley, California 94704, USA

DEADLINE: Applications must be received no later than 30 January 2004.

...... 18 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 FOR OFFICE USE ONLY

E.K. Zavoisky Stipend Program CONFIRMATION NO. DATE RECEIVED E.K. Zavoisky Stipend Check Sheet The ISMRM invites applications for stipends from the E.K. Zavoisky Program, established to support the attendance of scientists and clinicians at the ISMRM Twelfth Scientific Meeting. The program is SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO: named in honor of E.K. Zavoisky, pioneer in MR research from the Donald M. Hadley, M.B., Ch.B., Ph.D., Chair former USSR (see below). The purpose of the program is to support ...... International Society for Magnetic Resonance in Medicine scientists and clinicians who do not have access to the financial means to attend the ISMRM Twelfth Scientific Meeting. Applicants E.K. Zavoisky Stipend Committee eligible for the Educational Stipend Program (undergraduate and 2118 Milvia Street, Suite 201 graduate students and postdoctoral and medical trainees) are not Berkeley, California 94704, USA eligible for the Zavoisky Program. Those applicants who are first authors on the Abstract submission will be given priority. Applicant Name ______Family Name Given/First Name APPLICATION PROCEDURE: Degree______Applicants for support should submit the following: A printout of the electronically submitted abstract; Institution ______ Copy of email confirming online submission; A letter of application; Mailing Address ______ A curriculum vitae; A letter from an appropriate person at their institution ______(supervisor, head of department, etc.) certifying that no alternative funds are available. If a number of applicants from City ______the same institution are applying, the Committee would appreciate a unique comment on each, since funding might be State/Province ______limited in this situation; Completed check sheet. Country ______

WHERE TO APPLY: Postal Code/Zip+4 ______Donald M. Hadley, M.B., Ch.B., Ph.D., Chair International Society for Magnetic Resonance in Medicine Contact Phone Number ______E.K. Zavoisky Stipend Committee 2118 Milvia Street, Suite 201 Home Phone Number ______Berkeley, California 94704, USA E-mail Address ______DEADLINE: Applications must be received no later than 19 November 2003. Supervisor ______

About E.K. Zavoisky E.K. Zavoisky, from Kazan, Tatarstan, is nowadays acknowledged Have you submitted an Abstract to the ISMRM as the first author? as the inventor of Electron Spin Resonance. There is also strong support for the thesis that he was the first to observe a NMR signal □ YES □ NO as early as 1941, but he could not detect the signal reproducibly with the very basic apparatus he was able to build with the limited means available to him. What is the typical lowest airfare from your city to Kyoto? Due to the political situation at that time, Zavoisky´s work (US$) ______remained largely unnoticed in the west. Although unquestionably the first to observe spin resonance, the Nobel Prize Committee did not further consider his contribution due to the lack of follow-up ENCLOSED: papers and his move to other fields. □ E.K. Zavoisky Program Application Letter It is interesting to note that the CV of Zavoisky explicitly reports □ Curriculum Vitae his first trip to an international conference (1961). There is little doubt that the history of spin resonance would be seen from a □ Abstract and confirmation of online submission different perspective if Zavoisky had been able to pursue his work □ Supervisor’s Letter within the awareness of an international scientific community. It seems, therefore, to be more than appropriate to name a program established to help scientists from around the world to communicate their achievements in the memory of E.K. Zavoisky.

......

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 19 SMRT Update ISMRM Section for MR Technologists From The SMRT President

he SMRT has had a busy and productive quarter. The regional meetings T scheduled in September/October have been a great educational opportunity for many MR technologists. Overall attendance has been good and feedback from attendees has been positive. The SMRT has commit- ments from four additional regional sponsors in 2004. These sites include: 7 February 2004 in Warner Robins, Georgia, USA, organized by Garnold Bodenheimer; 28 February 2004 in Cleveland, Ohio, USA, organized by Julia Lowe; 20 March 2004 in Bethlehem, Pennsylvania, USA, organized by Linda SMRT Board Members. Varnis; 3 April 2004 in Ottawa, Ontario, Seated in front, l to r: Cindy Comeau, Laurian Rohoman, and Anne Sawyer-Glover. Seated l to r: Canada, organized by Rich Heroux and Muriel Cockburn, Heidi Berns, Judy Wood, Maureen Ainslie, Denise Davis, Gina Greenwood, Laurian Rohoman; February, 2004 in London, Bobbie Burrow, Silke Bosk, and Julia Lowe. Standing l to r: William Faulkner, Maureen Hood, England, UK, organized by Muriel Cockburn. Marcia Gervin, Gregory Brown, Julie Strandt-Peay, Andrew Cooper, James Stuppino, Raymond Cruz, Scott Kurdilla, John Koveleski, Nanette Keck, Kelly Baron, and Cindy Hipps. The SMRT Educational Seminars “home (not pictured: John Christopher, Todd Frederick, and Bart Schraa). study” program just published its 21st issue “Advances in Interventional MRI.” Accolades to editor Kelly Baron and her team of Pitfalls,” and Katsuyoshi Ito will review (ARRT) established an advisory board in June reviewers and question authors for their hard “Body and Cardiac Pitfalls.” 2003 to draft standards for radiologist work. The first home study was published in assistant certification (RA). In addition to 1998, “Functional MRI: Capabilities and The External Relations Committee, this effort, the Intersociety Conference held Limitations” by Mike Moseley and Gary chaired by Maureen Hood, continues to keep in August 2003 also met to discuss the topic Glover. These quarterly publications were abreast of global activities within health of Radiologist Extenders. A formal report is created to meet the growing need for high education organizations that may ultimately pending. The External Relations committee quality educational material for MR technolo- impact our profession. Maureen attended the will monitor the developments of advanced gists. This SMRT member-only benefit Health Professions Network meeting this practice technologists in the USA and its provides MR professionals the opportunity to September in Dallas, Texas, USA. The meeting impact on MR technologists worldwide. expand their knowledge while earning agenda covered issues in licensure, health THE SMRT continues to participate in Category A Continuing Education Credits at literacy and allied health education. High- the Associated Sciences Consortium at the their own pace. There are twenty home study lighted at this meeting is an effort by the RSNA. The 2003 theme is “Shaping our back issues in our library. Significant effort Health Occupations Students of America (HOSA) Future– Forces at Work.” Policy Board and many volunteer hours are required to to encourage health professionals to become members volunteer time at the Associated maintain and grow this important benefit. involved in their communities to promote health career opportunities at a local level. Science Booth to provide attendees with The Program Committee for the 13th information regarding SMRT membership Annual SMRT Meeting “Rising to Excellence” During our last Executive Committee benefits. to be held in conjunction with the ISMRM teleconference, Maureen provided an update The SMRT Executive Committee and Annual meeting in Kyoto, Japan, on 14-16 from the Alliance for Radiologic Excellence. Policy Board continue to work to promote May 2004, has selected topics and chosen They support the Consumer Assurance of membership in our section. The SMRT speakers for the two and a half day agenda. Radiologic Excellence (CARE) Act, a legislative encourages employers to provide financial A publication in Japanese advertising this proposal that would require states in the U.S. support for their MR technologists to event will be distributed to technologists to adopt minimum education and certification enhance their education by joining the through the Japanese Radiologic Society. standards for personnel performing these SMRT. The benefits provided by this premier Thanks to Dr. Atsuko Heshiki for assisting in procedures. An additional bill “RadCARE” professional organization created and this effort. Program Chair, Jim Stuppino, s1197 has five co-sponsors and has been sustained by MR technologists serve to and his committee continue to work to referred to the Committee on Health, solidify your commitment to your technolo- create a meeting that will serve the members Education, Labor and Pensions. The next gists’ growth and development. Many and technologists around the world, as well Alliance meeting will be held in Washington, technologists have limited access to profes- as reflect current developments in MR D.C. in January 2004. sional development or academic enrichment technology. Maureen also provided information on funds. By making these funds available for The SMRT and ISMRM Joint Presentation: the U.S. initiative to address the topic of educational opportunities, i.e. regional and Managing MR Artifacts and Pitfalls is scheduled advanced practice technologists in Radiology. annual SMRT meetings, your investment in on Monday, 17 May 2004 at 14.00. This This initiative is being driven by the your staff becomes visible and concrete. presentation will focus on addressing the increased demand for services in Radiology The $75.00 annual membership fee provides a physical and physiological causes of artifacts coupled with a shortage of qualified wealth of information and educational in MR images and resolution of these radiologists. The American College of benefits. Your institution or private practice Radiology (ACR), American Society of artifacts. Greg Brown and David Firmin will will surely prosper from this investment. speak on “The Physical Causes of Artifacts,” Radiologic Technologists (ASRT), and the Bill Bradley will discuss “Neuro and Vascular American Registry of Radiologic Technolgists — Maureen Ainslie, SMRT President

20 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 Report on the ISMRM Workshop on Cellular and Molecular Imaging in Diagnostics and Therapy

he ISMRM workshop on In addition, cellular Day 2 started with a cancer “Cellular and Molecular imaging shows a major session. Kenneth Krohn (Seattle) gave T Imaging in Diagnostics potential towards a lecture on imaging tumor proliferation and Therapy” was held understanding and using nuclear medicine techniques, during 2.5 days in Bordeaux, guiding novel cell repair followed by Michal Neeman (Rehovot) France, from 29 June to strategies based on on functional and molecular imaging 1 July of 2003. The venue stem cells. Ultrasound of vascular remodeling using multi- was “La Cité Mondiale” contrast agents may be modality contrast agents. Pat Price on the banks of the Garonne used as drug delivery (Manchester) concluded the therapy right in the heart of beautiful devices. These and part with a lecture on imaging of historic Bordeaux near the other emerging topics neoangiogenesis for monitoring cancer place where Thomas Jefferson in imaging, recently treatment. served as the US ambassador summarized as The therapy part started with a in France. The location and “molecular imaging,” presentation by Hans-Jürgen Wester the lively river festival being held at are fast becoming a hot topic in (Munich) on tumor targeting with the same time at Bordeaux, served as imaging research. The perspective of radio-labeled peptides, followed by a the perfect décor for the workshop. the Bordeaux meeting was to look at lecture by Clemens Lowik (Leiden) on A special reception was hosted by these fast developments from a clinical new optical methods for imaging of Professor Ducassou at the splendid viewpoint and to assess the potential metastatic tumor treatment. The Bordeaux town hall. in future therapies. session was concluded by short The workshop was endorsed by The symposium was organized presentations selected from the poster the Society of Molecular Imaging (SMI), around five major sessions. The first abstracts. which also assisted in the finances and session was on Contrast Agents for The topic of the fourth session scientific program. Despite the near- Molecular Imaging. Juri Gelovani was Inflammatory and Neurodegener- overlap with the rescheduled ISMRM (Houston) defined the field in his ative Diseases. Nicolas Grenier and Annual Meeting, the workshop attracted inaugural lecture on Molecular Imag- Vincent Dousset (Bordeaux) opened 160 participants from all over the world. ing. Bertrand Tavitian (Orsay) and the session with an overview on The well-filled auditorium, combined Silvio Aime (Torino) gave an overview imaging of macrophage activity with with outstanding chairpersons and on PET/SPECT and MRI contrast agents, MRI. Michael Schäfers (Münster) ample time for discussion, led to a very respectively. Frank Roesch (Mainz) presented a lecture on imaging athero- lively symposium. addressed the potentials of combined sclerotic plaque activity using PET/ MRI/SPECT/PET contrast agents. Sam SPECT. David Brooks (London) and Molecular Imaging is evolving Wickline (St. Louis) concluded the Bengt Langström (Uppsala) showed rapidly as a multi-modality imaging session with ultrasound and combined activity, and the Bordeaux symposium their resent results on imaging of MRI/ultrasound contrast agents. reflected this character by a balanced pathophysiological processes in mix of contributions using MRI, Nuclear The four sessions covering the Parkinson’s disease and Alzheimer Medicine, Ultrasound, and Optical rest of the symposium were split into a plaques, respectively. The therapy part techniques. Twenty-four invited diagnostics- and therapy–related part. included a presentation on imaging- presentations were held together with The second session was on targeted guided therapy of Parkinson’s disease four short presentations selected from pathways and physiological processes. by Rüdiger Hilker (Cologne) and a about fifty poster abstracts. Posters Uwe Haberkorn (Heidelberg) reported review of pharmaceutical perspectives could be discussed during coffee breaks on new Marker Gene/Marker Substrate by Martin Rausch (Basel). and a dedicated poster viewing session. combinations, and Jim Basilion The third (half) day concluded (Boston) presented recent advances the symposium with a special session The description of the human in imaging gene expression by MRI. on stem cells and progenitors. Pierre genome has opened medical research In the therapy part, Andreas Jacobs towards the development of new Charbord (Tours) gave a general (Cologne) showed results on the use of introduction of this booming field and molecular therapies, targeted to correct PET and MRI in imaging-guided gene set the tone for an exciting session. specific pathologies. Gene expression, therapy. Chrit Moonen (Bordeaux) a powerful tool for medicine of the Kishore Bhakoo (London) presented a presented methods to control image lecture on stem cell imaging and gene future, can be studied by modern guided transgene expression using MRI expression. Jeff Bulte (Baltimore) molecular imaging techniques, e.g. guided focused ultrasound. using PET, MRI, and optical methods. demonstrated tracking of magnetically

See Imaging page 22

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 21 ISMRM Workshop Announcement Imaging from page 21 MR in Drug Development: labeled progenitors and stem cells, followed by Mathias Höhn (Cologne) From Discovery to Clinical Therapeutic Trials showing in vivo MRI results of stem cell 2-3 April 2004 migration following stroke. Bernd Hilton McLean Tysons Corner, McLean, Virginia, USA Fleischmann (Bonn) concluded the session with a lecture on cellular Abstract Deadline: 19 FEBRUARY 2004 therapy in cardiology. Early Registration Deadline: 11 MARCH 2004 This cross-modality symposium brought together specialists of many different fields enjoying the wide- ranging discussions and presentations. The educational objectives appeared to have been met: (1) To be able to define the research fields of molecular and cellular imaging and their (potential) This workshop, the first meeting of its type, is seen as a major step forward in bringing impact in diagnosis and therapy of the together the various players who will help MR technologies approach their potential for future; (2) To be aware of new tech- beneficial impact on the drug development process. We believe that this will ultimately lead to nologies in molecular and cellular the development of more efficacious therapies, which will enhance public health and safety imaging targeted to specific biological worldwide. While attempts have been made previously to bring together representatives from pathways; (3) To describe the role of various sections of the scientific community to deal with imaging and drug development, few the major imaging modalities in of them have defined the most critical issues which need to be addressed. cellular and molecular imaging; While there has never been any doubt that MR technologies could have a significant impact on (4) To understand the (potential) drug development, the issue has been a lack of understanding of the problems and obstacles role of molecular imaging in advanced involved in achieving this. This meeting will provide an opportunity for scientists, clinicians, therapies, notably gene therapy; regulators, and industry representatives to study the issues that are being encountered or will (5) To understand the (potential) need to be addressed in order to advance the incorporation of MR technologies into drug role of cellular imaging in cell repair development. The workshop will cover aspects of the drug development process, technology therapy, notably via stem cells; considerations, and logistics regarding preclinical and clinical studies that will provide the (6) To understand the basic principles attendees with a broad perspective of the complex issues with which they must deal. Experts of imaging of key biological processes will provide a perspective on the basic metabolic processes of ischemia, and there will be such as angiogenesis, apoptosis, representation from both North America and Europe. inflammation. SESSION TOPICS EDUCATIONAL OBJECTIVES We conclude with special thanks Drug Chemistry: Preclinical Disease Models Upon completion of this workshop participants to Roberta Kravitz and the ISMRM Preclinical Safety Models: Translational Research should be able to: Overview of Drug Development Describe how MRI techniques can contribute office, together with Emily of the Phase II/III Regulatory Experiences to the drug development process; congress venue, for a perfect organiza- Panel Discussion on Future Directions Explain the various stages of drug develop- ment and how they relate to each other; tion despite the huge workload of the WORKSHOP ORGANIZING COMMITTEE Identify future applications and directions of rescheduled ISMRM meeting (which MRI methodologies and their future was held only 10 days following this David S. Lester, Ph.D., Chair applications to the pharmaceutical industry; Jeffrey L. Evelhoch, Ph.D. Recognize how MRI methodologies can be workshop). Many thanks also to the John R. Griffiths, M.B.B.S., D.Phil. SMI for generous support and help in incorporated into clinical trials for regulatory Nakissa Sadrieh, Ph.D. submission; putting together the Scientific Program. Liqun Wang, Ph.D. Describe how MRI will help in the transition We also acknowledge generous financial John C. Waterton, Ph.D. from preclinical to clinical trials in the drug Steve C. R. Williams, Ph.D. support by Philips Medical Systems, development process; Andy Van Bruggen, Ph.D. Describe the difference between use of MRI Siemens Medical Solutions, GE Medical for diagnostics vs. clinical therapeutic trials. Systems, Guerbet, and Novartis. We AUDIENCE DESCRIPTION hope that this workshop has helped This workshop is designed for users and developers WORKSHOP SPEAKERS of MRI methodologies from academia, industry stimulate the exciting field of (pharmaceutical and otherwise), and government. Speakers are confirmed from academia; molecular and cellular imaging. It will be of interest to those in industry and pharmaceutical, instrument, and IT corporations; academia who wish to hear regulatory perspec- and regulatory authorities. Workshop Organizing Committee tives, and regulators wanting to learn how MR techniques can aid the drug development process. Chrit Moonen, Andreas Jacobs, Michèle Prior experience is not required.

Allard, Vincent Dousset, and Nicolas Grenier INTERNATIONAL SOCIETY FOR FOR FURTHER INFORMATION, PLEASE CONTACT ISMRM

Phone: +1 510 841 1899 FAX: +1 510 841 2340 MAGNETIC RESONANCE IN MEDICINE E-mail: [email protected] Website: www.ismrm.org

22 MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 ISMRM Workshop Announcement Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective 21-23 March 2004, San Servolo, Venice, Italy The aims of this workshop are to facilitate the critical discussion of recent developments in cerebral perfusion MRI, to evaluate the different methodologies, to assess its clinical applications, as well as to review the field as it stands. The workshop will encompass both Dynamic Susceptibility Contrast MRI (DSC-MRI) and Arterial Spin Labeling (ASL) categories of techniques for CBF quantification. It will particularly emphasize a critical scientific assessment of the methods, assumptions, and limitations of each technique, the relative advantages and disadvantages of both methodologies, and comparison/validation against other non-MR perfusion methods. There will also be a discussion of the various basic science and clinical applications of these techniques. Throughout, the emphasis of the workshop will be on the key issues that have arisen in the development and application of MR perfusion within the last few years. Invited speakers will be encouraged particularly to go into significant technical depth and detail in their presentations. There will be dedicated poster sessions as well.

EDUCATIONAL OBJECTIVES WORKSHOP ORGANIZING COMMITTEE Upon completion of this workshop, participants should be able to: Alberto Bizzi, M.D., Local Organizer, Istituto Neurologico Carlo Besta, Identify the assumptions and limitations of DSC-MRI and ASL perfusion Milan, Italy imaging techniques; Fernando Calamante, Ph.D., Institute of Child Health, University College London, London, England UK Describe the different methods to measure the arterial input function, Thomas E. Conturo, M.D., Ph.D., Washington University School of and the “state-of-the-art” techniques to perform the deconvolution Medicine, St. Louis, Missouri, USA required for quantification of CBF using DSC-MRI; Susumu M. Mori, Ph.D., The Johns Hopkins University, School of Describe the various labeling approaches used in ASL to measure cerebral Medicine, Baltimore, Maryland, USA perfusion, as well as their relative advantages and disadvantages; Apply and interpret DSC-MRI and ASL, both in a clinical setting and in WORKSHOP SPEAKERS* basic research studies; David Alsop, Ph.D., Beth Israel Deaconess Medical School, Boston, Design the appropriate MR acquisition protocols and select the suitable Massachusetts, USA data modeling to assess cerebral perfusion in various applications. Richard B. Buxton, Ph.D., University of California, San Diego, La Jolla, California, USA AUDIENCE DESCRIPTION Fernando Calamante, Ph.D., University College London, London, England, UK The workshop will be aimed at MR physicists and engineers, but will also be Thomas E. Conturo, M.D., Ph.D., Washington University School of of great relevance to (technically inclined) cerebral physiologists, Medicine, St. Louis, Missouri, USA neuroscientists, and clinicians. Many students will also find it valuable. John A. Detre, M.D., University of Pennsylvania, Philadelphia, Pennsylvania, USA CREDIT HOURS AVAILABLE Jeff H. Duyn, Ph.D., National Institutes of Health, Bethesda, Maryland, The International Society for Magnetic Resonance in Medicine designates USA this educational activity for up to 15 category 1 credits towards the James R. Ewing, Ph.D., Henry Ford Hospital and Health Science Center, Physician’s Recognition Award of the American Medical Association. Each Detroit, Michigan, USA physician should claim only those credits actually spent in the activity. Valerij G. Kiselev, Ph.D., Freiburg University Hospital, Freiburg, Germany Leif Østergaard, M.D., Ph.D., Århus University Hospital, Århus, Denmark Laura M. Parkes, Ph.D., University of Nijmegen, Nijmegen, The Netherlands Abstract Deadline: 2 FEBRUARY 2004 Afonso C. Silva, Ph.D., National Institutes of Health, Bethesda, Maryland, USA Early Registration Deadline: 27 FEBRUARY 2004 A. Gregory Sorensen, M.D., Massachusetts General Hospital, Boston, Massachusetts, USA David L. Thomas, Ph.D., University College London, London, England, UK Matthias J. P. van Osch, Ph.D., University Medical Center Utrecht, Utrecht, The Netherlands Eric C. Wong, Ph.D. M.D., University of California at San Diego, La Jolla, California, USA *Partial List

INTERNATIONAL SOCIETY FOR

FOR FURTHER INFORMATION, PLEASE CONTACT ISMRM MAGNETIC RESONANCE IN MEDICINE Phone: +1 510 841 1899 FAX: +1 510 841 2340 E-mail: [email protected] Website: www.ismrm.org

MR PULSE VOL. 10, NUMBER 3 NOVEMBER 2003 23 15-21 MAY 2004 Bill Negendank Award Fund TWELFTH SCIENTIFIC MEETING In memory of William George Negendank, M.D., his colleagues in AND EXHIBITION the ISMRM MR of Cancer Study Group Kyoto, Japan have established the Bill Negendank Award Fund to recognize outstand- Mark Your ing young investigators in the field of Calendar! Cancer MR (see MR Pulse, Vol. 3, No. 3, ISMRM IMPORTANT DATES page 6). To make your tax-deduct- ible contribution, please send your AND DEADLINES check made payable to the ISMRM or submit your Visa, MasterCard, Ameri- 17 NOVEMBER 2003 FRIDAY, 14 MAY 2004 can Express, or Eurocard number, Deadline for receipt of Hosting Region Poster submissions. On-site Registration open from 14.00 - 20.00. expiration date, and amount you wish SMRT Poster Tour & Reception 18.30 - 20.00. to donate to the following address: 19 NOVEMBER 2003 Deadline for online receipt of Abstract submissions. Bill Negendank Award Fund SATURDAY, 15 MAY 2004 International Society for 19 NOVEMBER 2003 Weekend Educational Programs begin. Magnetic Resonance In Medicine Deadline for receipt of Student Stipend Applications. On-site Registration open from 06.30 - 18.00. 2118 Milvia Street, Suite 201 SMRT 13th Annual Meeting begins 07:.45. Berkeley, CA 94704, USA 19 NOVEMBER 2003 Deadline for receipt of E.K. Zavoisky Stipend SUNDAY, 16 MAY 2004 Program Applications. Weekend Educational Programs continue. International Society for On-site Registration open from 07.00 - 18.00. Magnetic Resonance in Medicine 21 JANUARY 2003 SMRT 13th Annual Meeting continues. Deadline for receipt of Proffered Papers for the 2118 Milvia Street, Suite 201 Berkeley, CA 94704, USA SMRT 13th Annual Meeting. MONDAY, 17 MAY 2004 Phone: +1 510-841-1899 FAX: +1 510-841-2340 30 JANUARY 2004 On-site Registration open from 06.30 - 18.30. Scientific Sessions begin at 07.45. E-mail: [email protected] Deadline for receipt of Clinical Resident Stipend Website: http://www.ismrm.org Program Applications. Technical Exhibition open at 10.00.

30 JANUARY 2004 TUESDAY – THURSDAY, © MR Pulse is published by the Deadline for receipt of New Entrant Stipend Program 18–20 MAY 2004 International Society for Magnetic Resonance in Medicine Applications. On-site Registration open from 06.30 - 18.00. Morning Categorical Courses begin at 07.00. Editor: 21-23 MARCH 2004 Scientific Sessions begin at 08.15. Patrick Stroman, Ph.D. ISMRM Workshop on Quantitative Cerebral Perfusion Technical Exhibition open at 09.30. Imaging Using MRI: A Technical Perspective Associate Editor: F. Scott Pereles, M.D. 2-3 APRIL 2004 FRIDAY, 21 MAY 2004 Executive Director: ISMRM Workshop on MR in Drug Development: On-site Registration for Scientific Meeting from Jane E. Tiemann From Discovery to Clinical Therapeutic Trials 06.30 - 12.30. Morning Categorical Courses begin at 07.00. Publications Manager: 2 APRIL 2004 Scientific Sessions begin at 08.15. Sheryl Liebscher Deadline for Advance Registration for the ISMRM Scientific Meeting adjourns at 12.30. Twelfth Scientific Meeting & Exhibition.

INTERNATIONAL SOCIETY FOR

MAGNETIC RESONANCE IN MEDICINE 2118 Milvia Street, Suite 201 Berkeley, CA 94704 USA