中英科技桥

Science Bridges China Research Profile

Name: Fujian- （徐福建） Position: Professor Institute/division: Beijing University of Chemical Technology Email: [email protected] Tel: 86-10-64443801

SUMMARY OF MY RELEVANT RESEARCH AREAS: Advanced bioactive surfaces and biomacromolecules via atom transfer radical polymerization

主要研究领域是利用原子转移自由基聚合法修饰各种医用材料表面和制备各种医用高分子材料

Primary Research interests:

 Surface Functionalization for Biomedical Applications Biocompatible and Antimicrobial Surfaces Control of Cell Adhesion and Detachment Controlled Surface Patterning Controlled Immobilization of Biomacromolecules  Functional/Smart Materials for Biomedical and Nanotechnology Applications Stimuli-Responsive Macromolecules for Drug Delivery Functional Non-viral Polymer Carriers for Gene Delivery  Living Radical Polymerizations (e.g. ATRP, RAFT and NMRP)

Topics in which would like to develop collaborative research:

Polymeric gene/drug delivery vectors

Relevant existing collaborations (academic/clinical/commercial) inside or outside China.

Publications and other outputs relevant to your interest in this programme

1) Xu, F.J.*; Neoh, K.G.; Kang, E.T. Bioactive surfaces and biomaterials via atom transfer radical polymerization. Progress in Polymer Science. 2009, 34(8): 719-761. 2) Xu, F.J.*; , W.T. Polymer vectors via controlled/living radical polymerization for gene delivery. Progress in Polymer Science. 2011, 36(9): 1099-1131. 3) , Z.H.; , W.B.; , J.; Tang, G.P.; Yang, W.T.; Xu, F.J.* Functionalized nonionic dextran backbones by atom transfer radical polymerization for efficient gene delivery. Macromolecules. 2011, 44(2):230-239. 4) Ping, Y.; , C.D.; Tang, G.P.; Li, J.S.; Li, J.; Yang, W.T.; Xu, F.J.*. Functionalization of chitosan via atom transfer radical polymerization for gene delivery. Advanced Functional Materials. 2010, 20(18):3106-3116. 5) Xu, F.J.*; Wang, Z.H.; Yang, W.T. Surface functionalization of polycaprolactone films via surface-initiated atom transfer radical polymerization for covalently coupling cell-adhesive biomolecules. Biomaterials. 2010, 31(12):3139-3147.

Relevant graphics, figures, pictures:

Dox group

PC-Dox/p53 in vivo retention

Mice after a variety of drug

treatment

PC-Dox/p53 NP

Cell immobilization Positive cells Gene

100µm 100µm