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GAIRDNER SYMPOSIUM June 6–9 2017 GAIRDNER SYMPOSIUM June 6–9 2017 A Celebration of Excellence PANTONE RED 485 MAINTAIN CLEAR SPACE AROUND THE LOGO EQUAL TO THE x-HEIGHT OF THE LETTER FORMS & ALWAYS USE A FUTURA FAMILY FONT FOR ASSOCIATED TEXTS. GAIRDNER SYMPOSIUM A Celebration of Excellence Welcome and congratulations on participating in the 2017 Canadian Student Health Research Forum, a unique venue offering students doing health research the opportunity to network, learn about cutting-edge research from internationally renowned experts and be recognized for their own outstanding scientific accomplishments. BRIAN POSTL, MD The involvement of students in research creates National Research Poster Presentation and the DEAN the pipeline to the future of research in this Canadian National Medical Student Research country. We are grateful we can contribute to Symposium. We trust that the valuable Max Rady College their exposures through poster presentations, connections you make with your peers, judges, of Medicine, Rady a CIHR Career Development Workshop and AFMC and CIHR leadership will provide career- Faculty of Health numerous networking opportunities. In enhancing opportunities as well as a fun and Sciences partnership with the Gairdner Foundation, we enjoyable experience. Our thanks to all the are pleased to host an all-Gairdner Symposium student groups for their energetic support in and note the exceptional opportunities hosting our visitors. for mentorship from these internationally Winnipeg is an exciting and vibrant place to recognized expert speakers who will be sharing live, work and conduct state-of-the-art health their insights and experience. research. We hope you enjoy your visit with We extend warm greetings and a “friendly us at the University of Manitoba campus and Manitoba” welcome to the record number have the opportunity to explore all that our city of participants from across Canada and has to offer. internationally who are taking part in the CIHR Gairdner Symposium Programme SYMPOSIUM Thursday, 8:00 Registration & Refreshments (Concourse) June 8, 2017 9:00 Welcome and Opening Remarks Dr. Kevin Coombs, Assistant Dean (Research), Max Rady Frederic Gaspard College of Medicine, University of Manitoba PROGRAMME Lecture Theatre 9:10 Chair’s Overview Geoff Hicks 9:15 Dr. James Hogg Basic Medical – University of British Columbia Sciences Building “The “Achilles’ heel” of the Lung” (Introduced by Dr. Andrew Halayko) 2017 >>> 730 William Avenue 10:00 Coffee Break (Mezzanine) 10:30 Dr. Lea Harrington – Université de Montréal “Critically short chromosome ends impact stem cell fate" (Introduced by Dr. Hao Ding) 11:15 Dr. Antoine M. Hakim – University of Ottawa “The Canadian Stroke Network: Bringing Knowledge to Society” (Introduced by Dr. Soheila Karimi) 12:00 Lunch and Poster Session (Brodie Atrium) 14:00 Dr. Janet Rossant – Hospital for Sick Children and University of Toronto “Establishing pluripotency and modelling disease” (Introduced by Dr. Geoff Hicks) 14:45 Coffee Break (Mezzanine) 15:15 Dr. William G. Kaelin, Jr. – Dana-Farber/Harvard Cancer Centre “New Approaches for Treating Anemia, Ischemia, and Cancer Emerging from Studies of the VHL Tumor Suppressor Protein” (Introduced by Dr. Mike Mowat) 16:00 Round Table Discussion 16:30 Awards Ceremony 17:15 Reception (Concourse) Apotex Fermentation Inc. Award – Molecular Biology Organizing James Gilchrist Lea Harrington Committee Canadian Institutes of Health Research – Poster Presentations Andrew Halayko Pingzhao Hu Meghan Azad Sabine Hombach-Klonisch Michael Jackson Caroline A. Cope Award – Oncology Patrick Choy Michael Jackson Bernard Jasmin Children’s Hospital Foundation Award – Child Health Kevin Coombs Tiina Kauppinen Soheila Karimi Dean of Graduate Studies – Poster Presentations Alysha Croker, CIHR Hassan Marzban Tiina Kauppinen Michael Czubryt Kirk McManus Forough Khadem Dean of Medicine – Poster Presentations Carla Dunton Don Miller Roger Mcleod 2017 Diagnostic Services Manitoba Awards 2017 Jessica Fraser Tooru Mizuno Tooru Mizuno – Translational Research Barbie Haddon Jim Nagy Nathan Nickel AWARDS – Imaging/Radiology AWARD Kent HayGlass Thomas Netticadan Karmin O COMMITTEES Geoff Hicks Mojgan Rastegar Trevor Pemberton E.L. Drewry Memorial Award – Health Research Ed Kroeger Miyoung Suh Garry Shen Graduate Students Association – Poster Presentations Yvonne Myal Bob Tate Bob Shiu Major Awards Hain, Emil and Lynette Scholarship – Excellence in Oncology Research Peter Nickerson Geoff Tranmer Louise Simard Committee Kimberly Ormiston Chris Siow Health Sciences Centre Foundation Inc. Award – Infection & Immunity/Neurobiology Chair – Yvonne Myal Nicole Szajcz-Keller, IMHA, CIHR/National Katinka Stecina Manitoba Medical Service Foundation Inc. Vern Dolinsky CIHR Poster Judging Panel Robert Tate – Poster Presentations Janice Dodd Terri Turner Co-Chairs – Jeff Wigle and – Awards for Excellence in Research Sachin Katyal Andrew Watson, AFMC Tara Beattie Teresa Zelinski Jeff Wigle Blake Ball Research Manitoba – Postdoctoral Fellow Poster Presentation Cynthia Ellison Kris Cowley Right Honourable Don Mazankowski Award - Excellence in Oncology Research Jeff Wigle Manitoba Poster Alysha Croker S.W. Prowse Memorial Award – Clinical Research Stephanie Booth Judging Panel Sanjiv Dhingra St. Boniface General Hospital Research Foundation Inc. Award – Cardiovascular Biology Chair- Michael Czubryt Janice Dodd 2017 Oncology Awards Blake Ball Jules Doré The Winnipeg Foundation – Travel Awards Committee Versha Banerji Christine Doucette Chair – Yvonne Myal Rajinder Bhullar Eftekhar Eftekharpour Sam Kung Kristine Cowley Paul Fernyhough Robert Tate Eftekhar Eftekharpour Jean-Eric Ghia Jeff Wigle Saeid Ghavami Sari Hannila GAIRDNER SYMPOSIUM Janet James William G. Rossant Hogg Lea Antoine Kaelin, Jr. Hospital for Sick University of British Harrington M. Hakim Dana-Farber/ Children and Columbia Université de University of Ottawa Harvard Cancer Montréal University of Toronto Gairdner Wightman Gairdner Wightman Center SPEAKERS Gairdner Wightman laureate Chair of the Gairdner laureate Gairdner laureate Medical Review Panel International 2017 >>> laureate William Kaelin obtained undergraduate and MD degrees from New Approaches Loss of the VHL tumor suppressor protein additional strategy for targeting transcription Duke University and completed his internal medicine training for Treating (pVHL) is the gatekeeper event in the most factors such as HIF2α (small molecule-mediated at the Johns Hopkins Hospital, where he served as chief common form of kidney cancer. pVHL is part target destabilization). Anemia, Ischemia, medical resident. He was a clinical fellow in medical oncology of an ubiquitin ligase that targets the alpha and Cancer subunits of the HIF transcription factor for Some cancers, such as a subset of acute at the Dana-Farber Cancer Institute and a postdoctoral fellow Emerging From proteasomal degradation. Binding of pVHL to leukemias and gliomas, are driven by IDH1 in the laboratory of David Livingston, during which time he HIFα requires that HIFα be prolyl hydroxylated or IDH2 mutations. These mutations cause Studies of the VHL was a McDonnell Scholar. He is currently a Professor in the by the EglN 2-oxoglutarate (2-OG)-dependent the accumulation of mM amounts of R-2 Tumor Suppressor dioxygenases, which act as oxygen sensors. hydroxyglutarate (R-2HG), which can interfere Department of Medicine at the Dana-Farber Cancer Institute HIF activates genes that promote adaptation with (usually inhibit) the activities of various Protein and the Brigham and Women's Hospital, Harvard Medical to hypoxia, including VEGF and EPO. EglN 2-OG-dependent enzymes, including the inhibitors are in clinical trials for anemia and JmjC histone demethylases, the TET DNA School. are promising in preclinical ischemia models. hydroxylases, and the EglN prolyl hydroxylases. Conversely, a HIF2 inhibitor is efficacious We showed that the effects of R-2HG in Dr. Kaelin is the Associate Director, Basic Science, for the Dana-Farber/Harvard Cancer Center. α in preclinical pVHL-defective kidney cancer leukemia are reversible and drugs that inhibit Doctor Kaelin is a member of the American Society of Clinical Investigation, the American College models and has entered phase 2 testing in man. R-2HG production are promising in early clinical of Physicians, the National Academy of Sciences and the National Academy of Medicine. He Our recent work with lenalidomide suggests an trials in leukemia patients. William G. recently served on the NCI Board of Scientific Advisors, the AACR Board of Trustees, and the IOM Kaelin, Jr. National Cancer Policy Board. He has received numerous awards including the MSKCC Paul Marks Dana-Farber/Harvard Prize, the AACR Richard and Hinda Rosenthal Prize, a Doris Duke Distinguished Clinical Scientist Cancer Center Award, the Canada International Gairdner International Award, the ASCI Stanley J. Korsmeyer Gairdner International Award, the Scientific Grand Prix of the Foundation Lefoulon-Delalande and the Institute of France, laureate and the Albert Lasker Prize. Janet Rossant, CC, PhD, FRS, FRSC, is President & Scientific Establishing Pluripotent stem cells provide a major resource Director of the Gairdner Foundation, SickKids Chief of Research Pluripotency and for studying human biology, modelling human Emeritus and a world-renowned expert in developmental disease and treating chronic illnesses. I Modelling biology. Widely known for her studies of the genes that will discuss how understanding the early Disease development of
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