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Connectivity of the Inferior Olivary Complex in Normal and Neonatally Hemicerebellectomized Rats

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Connectivity of the Inferior Olivary Complex in Normal and Neonatally Hemicerebellectomized Rats Loyola University Chicago Loyola eCommons Dissertations Theses and Dissertations 1980 Connectivity of the Inferior Olivary Complex in Normal and Neonatally Hemicerebellectomized Rats Rand S. Swenson Loyola University Chicago Follow this and additional works at: https://ecommons.luc.edu/luc_diss Part of the Anatomy Commons Recommended Citation Swenson, Rand S., "Connectivity of the Inferior Olivary Complex in Normal and Neonatally Hemicerebellectomized Rats" (1980). Dissertations. 1981. https://ecommons.luc.edu/luc_diss/1981 This Dissertation is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion in Dissertations by an authorized administrator of Loyola eCommons. For more information, please contact [email protected]. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. Copyright © 1980 Rand S. Swenson CONNECTIVITY OF THE INFERIOR OLIVARY COMPLEX IN NORMAL AND NEONATALLY HEMICEREBELLECTOMIZED RATS BY Rand S. Swenson A Dissertation Submitted to the Faculty of the Graduate School Of Loyola University of Chicago in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy February 1981 DEDICATION To my family, especially my wife, Mardrey Fish, my children, Krister and Ingrid, and my parents for their encouragement and patient understanding, this dissertation is lovingly dedicated. ii ACKNOWLEDGEMENTS The author takes this opportunity to thank Dr. Anthony J. Castro without whose patience, advice and guidance this dissertation would not have been completed . the members of his dissertation committee, Dr. John Disterhoft, Dr. James Hazlett, Dr. Robert Wurster and Dr. E. J. Neafsey for their helpful suggestions and criticisms. Miss Rebecca Auten for typing this manuscript. the anatomy department of Loyola University Stritch School of Medicine for affording me the opportunity of graduate study in anatomy. and the National College of Chiropractic for support of my graduate training. iii VITA The author, Rand S. Swenson, was born on November 14, 1953 in Mineola, New York. In 1971 he graduated from Stamford Central School in Stamford, New York. In September 1971 he entered the State University of New York College at Oneonta, from which he transfered to the National College of Chiropractic in September 1973. He received the degree of Bachelor of Science in human biology from the National College of Chiropractic in 1974 while pursuing his chiropractic studies, which he completed in December 1976 receiving the degree of Doctor of Chiropractic, summa cum laude. In January 1977 he joined the anatomy faculty of the National College of chiropractic, where he has taught neuroanatomy and gross anatomy. In March 1977 he began his graduate studies in the Department of Anatomy at Loyola Univeristy of Chicago's Stritch School of Medicine. In ·october 1979 he was awarded a post-doctoral fellowship starting in December 1980 at Loyola University Stritch School of Medicine, where he will work in the Departments of Anatomy and Physiology under Drs. Castro and Wurster. The author is married to Dr. Mardrey Fish and has two children, Krister and Ingrid. iv TABLE OF CONTENTS Dedication ............................................................. ii Acknowledgements ..........................••.....•........•........... iii Vita ....................•.........................•....•............... iv List of Figures .........•.......••..................••..•.•.•......... vii Introduction .................•.......................................... 1 Background ....................•........................•................ 4 General Morphology ....•......•............•.•...•.................. 4 Inferior Olivary Af ferents ...............•..•.......•.............. 9 Retrograde Experimentation .................................... 9 Orthograde Experimentation •................•........•........ 13 Olivocerebellar Connections ...................•................... 24 Anterograde Studies .....•............•.......•..•.•.......... 24 Retrograde Studies ....•.•...........•...•....•....•.......... 25 Physiology of Olivary Afferents ..•..............................•. 29 Plasticity ...........••.•..............•.•..••..•................. 3 7 Materials and Methods .....•............................................ 43 Surgical Procedure ..........................•...................•. 43 Horseradish Peroxidase Technique ....•............................. 44 Fink-Heimer Technique ..............................•..........•... 45 Autoradiographic Technique .................•...................... 45 Results ..............•..•..••.............•.....................•..•..• 4 7 Retrograde Analysis of Inferior Olivary Afferents ................. 47 Anterograde Analysis of Inferior Olivary Afferents ................ 55 Inferior Olivary Efferents ...............•.••..................... 61 Inferior Olivary Afferents in Hemicerebellectomized Rats .......... 63 Inferior Olivary Efferents in Hemicerebellectomized Rats .......... 66 Effects of Vestibular Nerve Lesion in Hemicerebellectomized Rats .. 67 Disc us s ion ............................................................. 6 8 Inferior Olivary Afferents ........................•............... 68 Spinal Cord ...............•...................•.............. 6 8 Caudal Brains tern ............................................. 70 Cerebellum ......•............................................ 76 Rostral Brains tern ...................•..........•............. 79 Cortex ........•.............................................. 89 v Inferior Olivary Efferents ....................................... 92 Inferior Olivary Afferents in Hemicerebellectomized Rats ......... 93 Effects of Vestibular Nerve Lesion in Neonatally Hemicerebellectomized Rats .................................. 99 Summary .............................................................. 101 Figures .............................................................. 104 List of Abbreviations ............................................... 20Lt Table ................................................................ 205 References ........................................................... 206.. vi TABLE OF FIGURES Figure Page 1. Inferior olivary subdivisions .................................... 105 2. Olivocerebellar topography ....................................... 107 3. Location of spinal neurons projecting to the IOC, case 877 ....... 109 4. Location of spinal neurons projecting to the IOC, case 923 ....... 111 5. Brain stem neurons projecting to the IOC, case 923 ............... 113 6. Photomicrographs of labeled neurons, case 923 .................... 115 7. Brain stem neurons projecting to the IOC, case 921 ............... 117 8. Photomicrographs of labeled neurons, case 923 .................... 119 9. Brain stem neurons projecting to the IOC, case 924 ............... 121 10. Photomicrographs of labeled neurons, case 924 .................... 123 11. Brain stem neurons projecting to the IOC, cases 922 and 877 ...... 125 12. Photomicrographs of labeled neurons, cases 922 and 877 ........... 127 13. Inferior olivary injection sites ................................. 129 14. Spina-olivary projections ........................................ 131 15. Dorsal Column nuclear projections to the IOC ..................... 133 16. Reticula-olivary projections ..................................... 135 17. Lateral reticular nuclear projections to the IOC ................. 137 18. Spinal trigemino-olivary projections ............................. 139 19. Vestibula-olivary projections .................................... 141 20. Vestibula-olivary projections .................................... 143 21. Nucleus prepositus hypoglossi projections to the IOC ............. 145 22. Rostral dentate projections to the IOC ........................... 147 23. Caudal dent a to-olivary projections ............................... 149 24. Ventral dentato-olivary projections .............................. 151 25. Rostral interposi to-olivary projections .......................... 153 2 6. Caudal interposito-olivary projections ........................... 155 27. Fastigio-olivary projections ..................................... 157 28. Caudal pretecto-olivary projections .............................. 159 29. Projections from the nucleus of the optic tract to the IOC ....... 161 30. Tecto-olivary projections •....................................... 163 31. Tecto-olivary project ions ........................................ 165 32. Rubral and prerubro-olivary projections .......................... 167 33. Lateral deep mesencephalic nuclear projection to the IOC ......... 169 34. Medial deep mesencephalic nuclear projections to the IOC ......... 171 35. Medial terminal nuclear projections to the IOC ................... 173 36. Prerubral projections to the IOC ................................. 175 3 7. Periaqueducto-olivary projections ................................ 177 38. Subparafascicular nucleo-olivary projections ..................... 179 39. Nucleus of Darkschewitsch projections to the IOC ................. 181 40. Cortico-olivary projections ...................................... 183 41. Summary of vestibula-ocular inputs to the IOC .................... 185 42. Somatosensory inputs to the IOC .................................. 187 43. Summary of Cerebella-olivary connections ......................... 189 44. Summary of reticular inputs to the IOC
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