Journal of Clinical Medicine Article High KDM1A Expression Associated with Decreased CD8+T Cells Reduces the Breast Cancer Survival Rate in Patients with Breast Cancer Hyung Suk Kim 1 , Byoung Kwan Son 2 , Mi Jung Kwon 3, Dong-Hoon Kim 4,* and Kyueng-Whan Min 5,* 1 Department of Surgery, Division of Breast Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Korea;
[email protected] 2 Department of Internal Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul 03181, Korea;
[email protected] 3 Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea;
[email protected] 4 Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea 5 Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Korea * Correspondence:
[email protected] (D.-H.K.);
[email protected] (K.-W.M.); Tel.: +82-2-2001-2392 (D.-H.K.); +82-31-560-2346 (K.-W.M.); Fax: +82-2-2001-2398 (D.-H.K.); Fax: +82-2-31-560-2402 (K.-W.M.) Abstract: Background: Lysine-specific demethylase 1A (KDM1A) plays an important role in epige- netic regulation in malignant tumors and promotes cancer invasion and metastasis by blocking the immune response and suppressing cancer surveillance activities. The aim of this study was to analyze Citation: Kim, H.S.; Son, B.K.; Kwon, survival, genetic interaction networks and anticancer immune responses in breast cancer patients M.J.; Kim, D.-H.; Min, K.-W. High with high KDM1A expression and to explore candidate target drugs.