Challenges and Opportunities for Bone Health

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Challenges and opportunities for bone health *Han-sung Kim1 1 Department of Biomedical Engineering & Institute of Medical Engineering, Yonsei University & Yonsei-Fraunhofer medical device lab Space mission One Man One Way Trip(2020) SpaceX Dragon, 2018년 50대 부부 화성 우주인 프로젝트 화성 개척 우주인 모집 2022년 Space Exploration Technologies Corp., USA Inspiration Mars Foundation, USA Mars One, Netherlands Spaceship2, Whiteknight2 The Spaceship company, USA H-IIB F4, (2013.8.4 예정) Curiosity (12.8.6) 선저우 神舟 호 귀환 Naro 3 13.1.30 ( ) 9 Epsilon-1, (2013.8.22 예정) (12.6.29) Diane Byerly, Ph.D. NASA Johnson Space Center Houston, TX Human Mars Mission Flight Profile Transit out: 161 days Mars Departure Jan. 24, 2022 Mars surface stay: 573 days Return: 154 days 3 Earth Departure 1 Jan. 20, 2020 Mars Arrival June 30, 2020 2 4 Earth Arrival June 26, 2022 Earth Orbit At least 2years Mars Orbit Piloted Trajectories Stay on Mars Surface are need!! Bone Loss in Space Bone Loss Bone Remodeling Bone Bone formation resorbtion Bone formation Normal bone Bone resorbtion Bone Bone formation resorbtion Bone Bone resorbtion formation Bone Loss in Space unloading Bed rest Animal experiment Cell experiment Hind-limb suspenstion Denervation 3D Clinostat Unloading Animal Model (Sciatic Nerve Neurectomy) Co-research with KARI Unloading animal model from sciatic nerve neurectomy Sciatic nerve neurectomy In-vivo micro-CT (Skyscan 1076) Ko et al. (2011), J Biomech Eng Circadian Rhythms Induced night shift by regulation of light Increased accumulation of ADT may lead to child obesity, adult disease Bone loss may leads to increase fracture risk and inhibit growth of bone Disturbance of circadian rhythms Pharmacotherapy Suppress Bone resorption Recovery Whole body vibration (non pharmacotherapy) Liver damage, stomach hemorrhage Muscle pain Hard to apply to patients and elders Vertigo, vomitWe and indigestionneed to develop alternative therapies capable of overcoming the limitation. Unloading Animal Model (Hind-Limb) + Partial Vibration Hind-limb model Emily (2002), J Appl Physiol The hind-limb unloading cage The hind-limb system Korea-Japan network Korea Japan Introduction Bone Hard Tooth tissue Cartilage Contrast Agent Liver Soft Blood vessel tissue Fat Lung Measurement Fat Volume fat lean threshold fat lumbr vertebral method lumbar skin vertebral lean skin .

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