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Paul Hardin, Ph.D. John W
Department of Biology The College of Arts + Sciences | Indiana University Bloomington About Paul Hardin Distinguished Alumni Award Lecture Thu., Oct. 18, 2018 • 4 to 5 pm • Myers Hall 130 Paul Hardin, Ph.D. John W. Lyons Jr. ’59 Chair in Biology, Texas A&M University Genetic architecture underlying circadian clock initiation, maintenance, and output in Drosophila Circadian clocks drive daily rhythms in metabolism, physiology, and behavior in organisms ranging from cyanobacteria to humans. The identification and analysis of “clock genes” in Drosophila revealed that circadian timekeeping is based on a transcriptional feedback loop Paul Hardin studied the development of the sea in which CLOCK-CYCLE (CLK-CYC) heterodimers activate transcription of their feedback urchin embryo in William Klein’s lab at Indiana repressors PERIOD (PER) and TIMELESS (TIM). Subsequent studies revealed that similar University, from where he received his Ph.D. in transcriptional feedback loops keep circadian time in all eukaryotes and, in the case of 1987. He did his postdoctoral fellowship with animals, that these feedback loops are comprised of conserved components. The “core” Michael Rosbash at Brandeis University, working feedback loop described above operates in conjunction with an “interlocked” feedback on the circadian rhythms of the fruit fly, Drosophila loop in animals to drive rhythmic transcription of hundreds of genes that are maximally melanogaster. His work with Michael Rosbash and expressed at different phases of the circadian cycle. These feedback loops operate in many, Jeff Hall has been instrumental to our understanding but not all, tissues in flies including the brain pacemaker neurons that control rest:activity of how circadian rhythms affect a myriad of rhythms. -
ASB M B Annual Meeting Highlights from the 2009
2010 ANNUAL MEETING, APRIL 24-28. ANAHEIM AWAITS! hlights fr ig om H June 2009 t h e 2 0 0 9 A S B M B A n n u al Meeting American Society for Biochemistry and Molecular Biology ANNUAL REVIEWS A Nonprofit Scientific Publisher INSIGHTFUL ANNUAL REVIEW OF TABLE OF CONTENTS BIOCHEMISTRY Without a License, or Accidents Waiting to Happen, E. Peter Geiduschek RESEARCH IN • A Journey in the World of DNA Rings and Beyond, James C. Wang BIOCHEMISTRY Vol. 78 • JUlY 2009 • The Biochemistry of Disease: Desperately Seeking Syzygy, John W. Kozarich • Biosynthesis of Phosphonic and Phosphinic Acid Natural STARTS WITH Editor: Products, William W. Metcalf, Wilfred A. van der Donk • New Antivirals and Drug Resistance, Peter M. Colman • Multidrug Resistance in Bacteria, Roger D. Kornberg ANNUAL Hiroshi Nikaido • Conformational Pathology of the Serpins: Themes, REVIEWS Stanford University School Variations, and Therapeutic Strategies, Bibek Gooptu, David A. Lomas of Medicine • Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions, Byron Caughey, Gerald S. Baron, Bruce Chesebro, Annual Review of Martin Jeffrey • RING Domain E3 Ubiquitin Ligases, Raymond J. Deshaies, Biochemistry, in publication Claudio A.P. Joazeiro • Regulation and Cellular Roles of Ubiquitin- since 1932, sets the standard Specific Deubiquitinating Enzymes, Francisca E. Reyes-Turcu, Karen H. Ventii, Keith D. Wilkinson • Recognition and Processing of Ubiquitin- for review articles in biological Protein Conjugates by the Proteasome, Daniel Finley • Degradation of chemistry and molecular biology. Activated Protein Kinases by Ubiquitination, Zhimin Lu, Tony Hunter • The Since its inception, these volumes Role of Ubiquitin in the NFκB Regulatory Pathways, Brian Skaug, Xiaomo have served as an indispensable Jiang, Zhijian J. -
RNA Society Newsletter August 2013
RNA Society Newsletter August 2013 From the Desk of the President, Rachel Green Whether we are taking classes, teaching classes, or just living our lives under the umbrella of the academic cycle, summer marks the time for sharing what we have learned during those long dark winter months. For the RNA Society, this summer was no exception where many of us attended the 18th annual RNA Society meeting in the heart of the Alps in Davos, Switzerland to share our new data and ideas. (Continued on p2) In this issue : From the Desk of the President, Rachel Green 1 RNA 2013 Meeting Review: Davos, Switzerland Election Results Announced 4 Junior Scientist Meetings Summary 4 RNA Lifetime Achievement Award 6 Volunteer Positions Available 7 Junior Scientist Corner 8 Chair of the Meetings Committee, David Lilley 9 From the desk of our CEO, James McSwiggen 11 Thank you volunteers 13 RNA Society supported meetings Meetings Reports 16 Upcoming meetings of interest 18 Employment Opportunities 21 1 The meeting organizers this year included the opening evening of the meeting a full session of two Swiss natives, Frederic Allain and Witold science was planned, headed off by Venki Filipowicz, as well as Adrian Krainer (RNA Ramakrishnan who gave a beautiful talk bringing Society president elect!), Osamu Nureki and Sarah together biochemical Woodson. In addition to their excellent guidance, the and structural organizers were helped at the organizational level by perspectives on the Simple Meetings (including Kristin Scheyer and process of decoding Mary McCann) who over the years have really during protein figured out our needs. -
Table of Contents (PDF)
June 28, 2016 u vol. 113 u no. 26 From the Cover 7106 Topological defects in liquid crystals E3619 Translation control in Fragile X syndrome E3686 Voltage-sensing phosphatase activities E3782 Aerobic glycolysis and learning 7261 Electric field sensing by bumblebees Contents THIS WEEK IN PNAS Cover image: Pictured is a polarized 7003 In This Issue optical micrograph of a plastic sheet with an array of holes drilled into it and suspended in a nematic-phase liquid LETTERS (ONLINE ONLY) crystal. Lisa Tran et al. found that such a sheet induced arrays of topological E3590 Reduced nitrogen dominated nitrogen deposition in the United States, but its defect lines in a nematic liquid crystal. contribution to nitrogen deposition in China decreased The authors further demonstrated how Xuejun Liu, Wen Xu, Enzai Du, Yuepeng Pan, and Keith Goulding the energy of the liquid crystal and the E3592 Reply to Liu et al.: On the importance of US deposition of nitrogen dioxide, geometry of the holes affect the defect coarse particle nitrate, and organic nitrogen patterns. The findings might have Yi Li, Bret A. Schichtel, John T. Walker, Donna B. Schwede, Xi Chen, Christopher M. B. applications in electronic displays, Lehmann, Melissa A. Puchalski, David A. Gay, and Jeffrey L. Collett Jr. where nematic liquid crystals are widely used. See the article by Tran et al. on E3594 Rise and fall of nitrogen deposition in the United States pages 7106–7111. Image courtesy of Enzai Du Lisa Tran. E3596 Adult pelvic shape change is an evolutionary side effect Philipp Mitteroecker and Barbara Fischer E3597 Reply to Mitteroecker and Fischer: Developmental solutions to the obstetrical dilemma are not Gouldian spandrels Marcia S. -
Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. -
Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J. -
2014-Program-For-Lecture-Gregory
OKLAHOMA SCHOOL OF SCIENCE AND MATHEMATICS Oklahoma stands out among other states in our dedication to providing OSSM an outstanding science and mathematics education to its gifted students at a time when our nation falls behind other countries in these areas. Senator Penny Williams Distinguished Lecture Series With just 22 classes graduated, OSSM alumni/alumnae are already Presents bringing substantial benefits to our state as they complete their degrees and move into their professions. “How Parkinson’s Disease Starts and •••••••••••••••••••••••• How It Might Be Stopped” • Eighty-five percent of OSSM alumni are remaining in scientific, technology, By engineering, and mathematics (STEM) fields for their careers! 2014 Capra Scholar • Of OSSM graduates now employed (many are still in undergraduate and graduate school or completing residencies in medical school), more than 60% GreGory A. PetSko, D.PHIl. are employed in Oklahoma. The fields of study and careers most chosen by OSSM graduates are engineering Arthur J. Mahon Professor of Neurology and Neuroscience and • Director, Helen and Robert Appel Alzheimer’s Disease Research Institute Weill Cornell Medical College (aerospace, biomedical, chemical, civil, computer, electrical, mechanical, Adjunct Professor of Biomedical Engineering Cornell University petroleum); medicine, medical research, and other health sciences; and other fields including computer science, technology, education, scientific research, Gyula and Katica Tauber Professor of Biochemistry and Chemistry, Emeritus Brandeis University business, and law. Adjunct Professor of Neurology Harvard Medical School Many OSSM alums are employed in many of Oklahoma’s finest corporations, Past-President, American Society for Biochemistry and Molecular Biology • President, International Union of Biochemistry and Molecular Biology hospitals and technical firms such as AT&T, Artificial Lift Company, Baptist Hospital, Benham Companies, Boeing, Chesapeake Energy, C. -
Molecular and Cellular Biology
MOLECULAR AND CELLULAR BIOLOGY Volume 5 December 1985 No. 12 Effect of Double-Strand Breaks on Homologous Recombination in Mammalian Cells and Extracts. Kyu-Young Song, Lavanya Chekuri, Sikha Rauth, Stacy Ehrlich, and Raju Kucherlapati................................ 3331-3336 Nucleotide Sequence and Expression In Vitro of cDNA Derived from mRNA of int-1, a Provirally Activated Mouse Mammary Oncogene. Y.-K. T. Fung, G. M. Shackleford, A. M. C. Brown, G. S. Sanders, and H. E. Varmus 3337-3344 Augmented Expression of Normal c-myc Is Sufficient for Cotransformation of Rat Embryo Cells with a Mutant ras Gene. William M. F. Lee, Manfred Schwab, David Westaway, and Harold E. Varmus ...................... 3345-3356 Diphtheria Toxin-Resistant Mutants of Saccharomyces cerevisiae. Jeou-Yuan C. Chen, James W. Bodley, and Dennis M. Livingston.................... 3357-3360 Recombinant Interleukin 2 Regulates Levels of c-myc mRNA in a Cloned Murine T Lymphocyte. John C. Reed, Daniel E. Sabath, Richard G. Hoover, and Michael B. Prystowsky............................................. 3361-3368 A Murine Recombinant Retrovirus Containing the src Oncogene Transforms Erythroid Precursor Cells In Vitro. Steven M. Anderson, S. Peter Klinken, and W. David Hankins ...................................... 3369-3375 Pichia pastoris as a Host System for Transformations. James M. Cregg, Kevin J. Barringer, Anita Y. Hessler, and Knut R. Madden.................... 3376-3385 Members of the src and ras Oncogene Families Supplant the Epidermal Growth Factor Requirement of BALB/MK-2 Keratinocytes and Induce Distinct Alter- ations in Their Terminal Differentiation Program. Bernard Weissman and Stuart A. Aaronson .................................................. 3386-3396 A Deletion of the 3' End of the Drosophila melanogaster hsp7O Gene Increases Sta- bility of Mutant mRNA During Recovery from Heat Shock. -
Salk Bulletin, January 28 - February 4, 2019 Date: Friday, January 25, 2019 2:34:00 PM
From: Bulletin To: "[email protected]" Subject: Salk Bulletin, January 28 - February 4, 2019 Date: Friday, January 25, 2019 2:34:00 PM Salk Bulletin Monday, January 28, 2019 Monday, January 28, 2019 4:00 pm – 5:00 pm "Evasion of IL-22-Mediated Antimicrobial Responses by Bacterial Pathogens" Manuela Raffatellu, M.D., Professor, Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics UNIVERSITY OF CALIFORNIA SAN DIEGO Leichtag Room 107 Host: Nissi Varki, M.D. Contact: Andrea Bribiesca, [email protected] Tuesday, January 29, 2019 Tuesday, January 29, 2019 12:00 pm "Circadian Rhythms and Gene Expression Regulation in Different Neurons or Cell Types" Michael Rosbash, Ph.D., Peter Gruber Professor of Neuroscience, Investigator, Howard Hughes Medical Institute; Professor, Department of Biology, Brandeis University President’s Lecture Series SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE Fishman Auditorium Host: Rolf Bodmer Contact: Wendy Lyon, [email protected] Tuesday, January 29, 2019 12:00 pm “GPCR Signaling Pathways as Critical Regulators of Body Weight and Glucose Homeostasis: Clinical Implications” Jürgen Wess, Ph.D., Chief, Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases UNIVERSITY OF CALIFORNIA SAN DIEGO Leichtag Building, Room 107 Host: Joan Heller Brown Tuesday, January 29, 2019 3:00 pm “Drugging ‘the Undruggable’. The Augmented Reality of Emerging Therapeutics” Artem Cherkasov, Ph.D., Professor, Faculty of Medicine, University of British Columbia; Head, Therapeutics Development Core Vancouver Prostate Centre SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE Fishman Auditorium Host: Ze’ev Ronai Contact: [email protected] Tuesday, January 29, 2019 4:00 pm “Understanding Sensorimotor Integration During Odor-guided Behaviors” Dinu Florin Albeanu, Cold Spring Harbor Laboratory Neurosciences Seminar Series UNIVERSITY OF CALIFORNIA SAN DIEGO CNCB Marilyn G. -
Biophysical Society 58Th Annual Meeting February 15–19, 2014 | San Francisco, California
ABSTRACT DEADLINE: OCTOBER 1, 2013 | EARLY REGISTRATION DEADLINE: JANUARY 8, 2014 Biophysical Society 58th Annual Meeting FEBRUARY 15–19, 2014 | SAN FRANCISCO, CALIFORNIA BIOPHYSICS OF CELL DIVISION AND National Lecturer SPATIAL RELATIONSHIPS Workshops Susan Biggins, Fred Hutchinson Cancer Workshops will be held on Sunday and Carlos Bustamante Research Center, Co-Chair Tuesday evenings. University of California, Berkeley Wallace Marshall, University of California, San Francisco, Co-Chair POLARIZABLE FORCE FIELDS FROM Daniel Fletcher, University of California, BIOMOLECULAR SIMULATIONS A Journey Through Cellular Processes: Berkeley One Molecule at a Time Matthieu Piel, Curie Institute, France Benoit Roux, University of Chicago, Co-Chair Alexander Mackerell, University FORCE GENERATION IN CELL AND of Maryland, Co-Chair TISSUE NETWORKS Vijay Pande, Stanford University Michael Sheetz, Columbia University, MOLECULAR BASIS FOR REGULATION Teresa Head-Gordon, University Co-Chair Symposia 2+ of California, Berkeley OF CA CHANNELS Clare Waterman, NHLBI, Co-Chair Stephen Long, Memorial Sloan- Symposia will be held Sunday through Alexander Bershadsky, Weizmann Kettering Cancer Center, Co-Chair SINGLE MOLECULE DYNAMICS USING Wednesday. Institute of Science, Israel FRET/LRET Amy Lee, University of Iowa, Co-Chair Frank Jülicher, Max Planck Institute for the Achillefs Kapanidis, University of Annette Dolphin, University College Physics of Complex Systems, Germany FORCE SENSING IN MUSCLE London, United Kingdom Oxford, United Kingdom, Co-Chair Mathias Gautel, -
The Nobel Prize in Physiology Or Medicine
The 2017 Nobel Prize Physiology or Medicine Alfred Nobel (1833–1896) As a child, Alfred dreamed of becoming a writer, but his father had other expectations of him and his brothers. Dynamite 1867 Alfred Nobel invented dynamite, and during his life he managed to earn a lot of money from this invention. The will Alfred Nobel died on December 10, 1896 According to the will of Alfred Nobel, a yearly Prize should be awarded in five categories: physiology or medicine, physics, chemistry, literature and peace. And it should reward those who “shall have conferred the greatest benefit to mankind.” Prize Award Ceremony Nobel Day, December 10 each year The Prize consists of a medal, a diploma and a sum of money. Sweden’s King Carl XVI Gustaf presents the medal and diploma to each Laureate at Stockholm Concert Hall. The Nobel Prize in Physiology or Medicine This Prize is a reward for discoveries that help us to understand how organisms work, or that lead to important cures for a disease. Examples of earlier Laureates The Nobel Prize in Physiology or Medicine Structure of the DNA molecule 1962 Penicillin 1945 Francis Crick, James Watson and Maurice Wilkins Alexander Fleming, Ernst Chain and Howard Florey Jeffrey C. Hall, Michael Rosbash and Michael W. Young The 2017 Nobel Prize in Physiology or Medicine For their discoveries of molecular mechanisms controlling the circadian rhythm Illustration: Niklas Elmehed © Nobel Media AB 2017 The people The 2017 Laureates are three American researchers. In 1984 they described in detail A built-in the first gene that controls the internal clock. -
Experimentally Demonstrated the Intrinsic Instability of the Fluorite-Type Zr Cation Network
0246110 Rta(i) 1 1,2 l,4 1,6 1,l 2 22 Rta(i) Figure 2. Temperature dependence of Zr-FTfor pure orthorhombic zirconia Figure 3 Temperature dependence of Zr-0 shell in tetragonal zirconia solid solution Our study has experimentally demonstrated the intrinsic instability of the fluorite-type Zr cation network. Coherent scattering beween Conclusions central Zr ion and distant cations is weaker and vibration modes of the Zr-cation network are It is found that, for all of zirconia solid softer in tetragonal zirconia than in monoclmic, solutions studied, the dopant-oxygen distances are orthorhombic, or stabilized cubic zirconia. In si@icantly ddferent from the Zr-0 distances. addition, the outer foux oxygens in the 8-fold The dopant-cation distances, on the other hand, coordinated Zr-0 polyhedron are only loosely are usually very close to the Zr-Zr distance, solutions. A bonded and are subject to very large static and confirming the formation of solid dynamic distortions. This effect is illustrated by general structural picture for zirconia solid the expanded portion of the Fourier transform solutions is one that places the dopant cations shown in Figure 3. randomly on tbe Zr sites in the cation network, but with distorted and sometimes very different Dopant Structure dopant-oxygen polyhedra surrounding these dopants. In the case of Ge4+ doping and Y-Nb We have also successfully performed co-doping, short-rangecation ordering has been EXAFS experiments at the dopant absorption suggested from our EXAFS results. edges for doped zirconia solid solutions. Dopants Based on the above structural information studied include the Ce-,Nb-, and Y-K edges as and other EXAFS results obtained from NSLS, well as Ce-LIn edge.