Potential and Mentality of Genius and Inspiration and Milestone
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Paul Hardin, Ph.D. John W
Department of Biology The College of Arts + Sciences | Indiana University Bloomington About Paul Hardin Distinguished Alumni Award Lecture Thu., Oct. 18, 2018 • 4 to 5 pm • Myers Hall 130 Paul Hardin, Ph.D. John W. Lyons Jr. ’59 Chair in Biology, Texas A&M University Genetic architecture underlying circadian clock initiation, maintenance, and output in Drosophila Circadian clocks drive daily rhythms in metabolism, physiology, and behavior in organisms ranging from cyanobacteria to humans. The identification and analysis of “clock genes” in Drosophila revealed that circadian timekeeping is based on a transcriptional feedback loop Paul Hardin studied the development of the sea in which CLOCK-CYCLE (CLK-CYC) heterodimers activate transcription of their feedback urchin embryo in William Klein’s lab at Indiana repressors PERIOD (PER) and TIMELESS (TIM). Subsequent studies revealed that similar University, from where he received his Ph.D. in transcriptional feedback loops keep circadian time in all eukaryotes and, in the case of 1987. He did his postdoctoral fellowship with animals, that these feedback loops are comprised of conserved components. The “core” Michael Rosbash at Brandeis University, working feedback loop described above operates in conjunction with an “interlocked” feedback on the circadian rhythms of the fruit fly, Drosophila loop in animals to drive rhythmic transcription of hundreds of genes that are maximally melanogaster. His work with Michael Rosbash and expressed at different phases of the circadian cycle. These feedback loops operate in many, Jeff Hall has been instrumental to our understanding but not all, tissues in flies including the brain pacemaker neurons that control rest:activity of how circadian rhythms affect a myriad of rhythms. -
RNA Society Newsletter August 2013
RNA Society Newsletter August 2013 From the Desk of the President, Rachel Green Whether we are taking classes, teaching classes, or just living our lives under the umbrella of the academic cycle, summer marks the time for sharing what we have learned during those long dark winter months. For the RNA Society, this summer was no exception where many of us attended the 18th annual RNA Society meeting in the heart of the Alps in Davos, Switzerland to share our new data and ideas. (Continued on p2) In this issue : From the Desk of the President, Rachel Green 1 RNA 2013 Meeting Review: Davos, Switzerland Election Results Announced 4 Junior Scientist Meetings Summary 4 RNA Lifetime Achievement Award 6 Volunteer Positions Available 7 Junior Scientist Corner 8 Chair of the Meetings Committee, David Lilley 9 From the desk of our CEO, James McSwiggen 11 Thank you volunteers 13 RNA Society supported meetings Meetings Reports 16 Upcoming meetings of interest 18 Employment Opportunities 21 1 The meeting organizers this year included the opening evening of the meeting a full session of two Swiss natives, Frederic Allain and Witold science was planned, headed off by Venki Filipowicz, as well as Adrian Krainer (RNA Ramakrishnan who gave a beautiful talk bringing Society president elect!), Osamu Nureki and Sarah together biochemical Woodson. In addition to their excellent guidance, the and structural organizers were helped at the organizational level by perspectives on the Simple Meetings (including Kristin Scheyer and process of decoding Mary McCann) who over the years have really during protein figured out our needs. -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Table of Contents (PDF)
June 28, 2016 u vol. 113 u no. 26 From the Cover 7106 Topological defects in liquid crystals E3619 Translation control in Fragile X syndrome E3686 Voltage-sensing phosphatase activities E3782 Aerobic glycolysis and learning 7261 Electric field sensing by bumblebees Contents THIS WEEK IN PNAS Cover image: Pictured is a polarized 7003 In This Issue optical micrograph of a plastic sheet with an array of holes drilled into it and suspended in a nematic-phase liquid LETTERS (ONLINE ONLY) crystal. Lisa Tran et al. found that such a sheet induced arrays of topological E3590 Reduced nitrogen dominated nitrogen deposition in the United States, but its defect lines in a nematic liquid crystal. contribution to nitrogen deposition in China decreased The authors further demonstrated how Xuejun Liu, Wen Xu, Enzai Du, Yuepeng Pan, and Keith Goulding the energy of the liquid crystal and the E3592 Reply to Liu et al.: On the importance of US deposition of nitrogen dioxide, geometry of the holes affect the defect coarse particle nitrate, and organic nitrogen patterns. The findings might have Yi Li, Bret A. Schichtel, John T. Walker, Donna B. Schwede, Xi Chen, Christopher M. B. applications in electronic displays, Lehmann, Melissa A. Puchalski, David A. Gay, and Jeffrey L. Collett Jr. where nematic liquid crystals are widely used. See the article by Tran et al. on E3594 Rise and fall of nitrogen deposition in the United States pages 7106–7111. Image courtesy of Enzai Du Lisa Tran. E3596 Adult pelvic shape change is an evolutionary side effect Philipp Mitteroecker and Barbara Fischer E3597 Reply to Mitteroecker and Fischer: Developmental solutions to the obstetrical dilemma are not Gouldian spandrels Marcia S. -
NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) Elas Proferiramduranteassolenidadesdepremiação
TEMA EM DESTAQUE NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) LUZINETE SIMÕES MINELLA RESUMO NO TRONO DA CIÊNCIA I: MULHERES NO NOBEL DA FISIOLOGIA OU MEDICINA (1947-1988) FISIOLOGIA CIÊNCIA I: MULHERES NO NOBEL DA NO TRONO DA O artigo reflete sobre as trajetórias das cinco cientistas que receberam o Nobel na Fisiologia ou Medicina entre 1947 e 1988, abordadas como as pioneiras dessa área no curso desta premiação criada em 1901. Numa perspectiva balizada pelos avanços da crítica feminista à ciência, dos campos de gênero e ciências e da história das ciências, o artigo sintetiza vários aspectos ligados às origens e formação dessas mulheres, ressaltando as interferências de gênero na construção das suas carreiras. A discussão visa a contribuir para o debate sobre a categoria feminização. Foram consultadas várias fontes, entre elas o site do prêmio no qual podem ser encontradas suas autobiografias, bem como os discursos e palestras que elas proferiram durante as solenidades de premiação. MULHERES • PRÊMIO NOBEL • FISIOLOGIA • MEDICINA IN THE REALM OF SCIENCE I: WOMEN NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE (1947-1988) ABSTRACT The article discusses the path of the five women scientists who received the Nobel Prize in Physiology or Medicine, between 1947 and 1988, regarded as pioneers in this area in the course of this award created in 1901. In a perspective marked by advances in feminist criticism of science, in the fields of gender and science and the history of science, this article summarizes various aspects linked to the v.47 n.163 p.70-93 jan./mar. -
Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. -
Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J. -
Pages 459 To
459 University Organization Board of Trustees The dean of the Heller School for Social study abroad, international students and Policy and Management oversees the scholars, and student enrichment services), academic activities of the school and its Hiatt Career Center, research and planning, Under Massachusetts law, the Board of work in such policy areas as children, and student life (including athletics, Trustees is the governing body of the youth, families, health, mental health, chaplaincy, community service, health university. There are four faculty substance abuse, disabilities, aging, social services, intercultural center, judicial representatives and three student change, and economic inequalities. orientation, psychological counseling, representatives to the board who participate residence life, and student activities). in board meetings and have votes on the The dean of the Brandeis International several committees. The president of the Business School oversees the academic, The senior vice president for university, the chair of the Fellows, the professional, and development activities communications administers and executes president of the Brandeis National of the university’s second professional critical university-wide internal and Committee, and the president of the school. Research areas of the school external communications, overseeing the Alumni Association serve ex officio. The include economic policy, finance, global communications emergency response plan board annually elects an alumni term entrepreneurship, international business, and directing all crisis communications. trustee who serves a four-year term with regional economics integration, and trade Further, she is responsible for an integrated full voting privileges. and exports. marketing communications program that highlights Brandeis’s research The President accomplishments, academic excellence, The president, the chief executive officer of The Faculty Senate social justice mission, and scholarly the university, is appointed by the Board of contributions to the Jewish community. -
The Rise and Rise of a Biology Superstar
JAPAN | NATURE INDEX PROFILE: YOSHINORI OHSUMI THE RISE AND RISE OF A BIOLOGY SUPERSTAR Nobel laureate Yoshinori Ohsumi’s persistent study of baker’s yeast spawned an exciting new field, and proves the value of supporting scientists in pursuit of their passion BY TIM HORNYAK biology superstar owes a lot to the humble microorganism that has provided the world with bread and Abooze since antiquity. Yoshinori Ohsumi’s dogged study of yeast’s inner workings spanned PARKS BENJAMIN decades, eventually winning the 2016 Nobel Prize in Physiology or Medicine for his insights into how cells digest and recycle their own components. Autophagy, as these processes are known, is the subject of wide-ranging research in such fields as longevity and cancer. But, few people knew much about Ohsumi before he took the podium at the Karolinska Institute in Stockholm in December 2016 to deliver his Nobel lecture in which he extolled yeast’s many lessons, and its “wonderful gifts of sake and liquor.” It’s unusual for the medicine Nobel to go to a single researcher, and Ohsumi’s win high- lighted the importance of individual research in the age of large, international collaborations. Yoshinori Ohsumi’s ground-breaking work on yeast molecules was largely a solo pursuit. “In my time, I would do research because I was interested in a subject, but young people Ohsumi then returned to the University Ohsumi estimates that fewer than 20 papers want to know whether a subject will yield a of Tokyo and in 1988 opened his own lab. on autophagy were published each year when good paper or be beneficial for their career,” He focused on yeast vacuoles, specialized he began, but that tally is now in the thousands. -
Creating New Value
OECD Learning Compass 2030 Transformative Competencies Creating New Value Shinya Yamanaka Professor, Kyoto University Director of the Center for iPS Cell Research and Application (CiRA) 2012 Nobel Prize in Physiology or Medicine Award Winner Kyoto, Japan OECD Learning Compass 2030 Transformative Competencies: Creating New Value Shinya Yamanaka1 Professor, Kyoto University Director of the Center for iPS Cell Research and Application (CiRA) 2012 Nobel Prize in Physiology or Medicine Award Winner Kyoto, Japan I believe that “creating new value”, as articulated by the For students who aspire to become scientists, it is OECD Learning Compass 2030, is a competency that important to reiterate that the natural world is still full of every student needs for the future. This is especially true “unknowns”. The mission of scientists is to discover these for aspiring scientists. unknowns. In much the same way that artists use free thinking to create unique works on a blank canvas, One of the most important competencies in science is the scientists use their free thinking to develop and test willingness to doubt commonly accepted theories. unique hypotheses about unknowns. Such discoveries Scientists must be able to think for themselves, without can contribute to society in significant ways, through believing 100% of what textbooks and teachers tell advancements in science and technology, but they also them. It is with this mind-set that people generate new involve potential risks and threats to humans. Scientists ideas. This is particularly important today, given the must therefore have high ethical standards, as well. I breakneck pace at which developments in science and sincerely hope that many children will develop an technology are advancing; and it will only become more interest in the natural sciences and grow up to become important as progress accelerates further. -
The Research Imperative Arnold Theiler Memorial Lecture 2017
The Research Imperative Arnold Theiler Memorial Lecture 2017 Robert O. Gilbert, FRCVS Professor, Ross University School of Veterinary Medicine Professor Emeritus, Cornell University Outline • Personal research in postpartum uterine disease of dairy cows • Reflections on research more generally • Production animal research • Research in veterinary practice • Academic practice • Private practice • The research imperative • For Society and the Profession • For Universities • For individuals Up to circa 1990 • Most agreed “endometritis” was bad for reproduction • Several disagreed • Miller HV, et al., Bov.Pract. 1980 • Griffin, Hartigan & Nunn, Theriogenology, 1974 a,b • Diagnosis • N. America: palpation and visible exudate • Incidence < 20 % • Europe: vaginoscopy • Incidence ~ 40 % Maurice E. “Pete” White Editor, Cornell Veterinarian Creator, “Consultant” Bovine Endometritis: The burden of proof. Cornell Vet., 1992 Endometrial cytology Endometrial cytology Endometritis • Cows at 40 – 60 days postpartum • End of voluntary waiting period • 5 dairy herds in Central New York • Endometrial cytology • No further involvement in management • Followed up via dairy records Endometritis Survival Analysis Effect of Endometritis at 7 weeks 1.0 Endometritis-negative Endometritis-positive 0.8 0.6 122 days 158 days P = 0.002 Proportion Open 0.4 30% censored 0.2 P = 0.003 18% censored 0.0 0 50 100 150 200 250 300 350 Time (Days) Some central questions • Which pathogens are primarily responsible for endometritis? • Which metabolic and immune factors mediate susceptibility to and pathogenesis of endometritis? • How does endometritis mediate infertility? Which pathogens cause endometritis? • Most cows have postpartum uterine bacterial infection • Only a subset develops disease • Extensively studied by conventional means • Mixed postpartum population initially judged to be insignificant (Griffin, Hartigan, Nunn, 1974) • Persistence of Trueperella pyogenes beyond 21 days detrimental to fertility • Synergistic action of T. -
WOMEN in STEM WORD SEARCH Learn About Women Scientists Who Broke MARY JACKSON Boundaries and Made Important Discoveries Credit: NASA
WOMEN IN STEM WORD SEARCH Learn about women scientists who broke MARY JACKSON boundaries and made important discoveries Credit: NASA V WANGARIMAATHAIMEQNW QAWAZSXEDCFRVGHAITIA XMLONOSKCAJYRAMRRPLL ZAPELNMTIOPYBNMYUIKK ORBINJANEGOODALLCRNC NYDBATRKJLXDTOCEEAAO IGOAQSIDFYOWRNBAICRT KONGHJMNOQPEVAMKRHFN GLNZXCAVALNLLUQEAEDI DDABNMEWETRLYXKYMLNL OASPOIJUIIEFERLDSCIC HRTAZWEESKXRAEQTSALC YOREYAMTREPPEOGAIRAM HSIWEEIXRYATYSUJMSSA TSCESOSRAHYNMPHIKOOR OAKIDSOATGPMOERKINRA RVLFAPNRNRTUYOUYOUQB OWAERTEYMDGUOFXBCVOR DENXOBIVANDANASHIVAA MMDYLADDRANYAMEIRAMB Answer key on page 4 Alice Ball Mae Jemison Rachel Carson Barbara McClintock Marie Curie Rosalind Franklin Bertha Parker Marie Maynard Daly Tu Youyou Donna Strickland Maria Goeppert Mayer Valentina Tereshkova Dorothy Hodgkin Mary Golda Ross Vandana Shiva Jane Goodall Mary Jackson Wangari Maathai An agency of the Lise Meitner Mary Leakey Government of Ontario WOMEN IN STEM WORD SEARCH Learn about women scientists who broke MAE JEMISON boundaries and made important discoveries Credit: NASA 1. Marie Curie (1867-1934) Polish-born French physicist and chemist. She was the first woman to be awarded a Nobel Prize (Physics), in 1903, for her research on X-rays and radioactivity, and the first person to be awarded a second Nobel Prize (Chemistry), in 1911, for her discovery of the elements polonium and radium. 2. Lise Meitner (1878-1968) Austrian-born nuclear physicist. Her research led to the discovery of uranium fission, for which only her male colleague, Otto Hahn, was awarded the Nobel Prize in 1945. 1n 1997, an element was named meitnerium (Mt) in her honour. 3. Alice Ball (1892-1916) Black American chemist. She developed the first effective treatment for leprosy, later known as the Ball Method, which was widely used for over thirty years until the introduction of sulfone drugs. 4. Maria Goeppert Mayer (1906-1972) German-born American mathematician and physicist.