Haematopoesis Solarsystem

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Haematopoiesis Peripheral blood Lymph nodes Bone marrow Haematopoietic stem cell B lymphocyte Pro-B Lymphoid-primed multipotent progenitor Common Multipotent lymphoid progenitor progenitor Lymphoblast Monoblast Promonocyte Granulocyte- monocyte Monocyte Common myeloid progenitor progenitor Bone marrow NK-cell Neutrophilic Neutrophilic myelocyte metamyelocyte Neutrophilic Pro-T Myeloblast band cell Neutrophilic granulocyte Promyelocyte Thymus Eosinophilic myelocyte Megakaryocyte-erythroid T lymphocyte progenitor Bone marrow Proerythroblast Eosinophilic metamyelocyte Megakaryoblast Basophilic Eosinophilic myelocyte band cell Basophilic erythroblast Peripheral blood Eosinophilic granulocyte Basophilic metamyelocyte Polychromatic Promegakaryocyte erythroblast Basophilic Orthochromatic band cell erythroblast The illustration of haematopoiesis as a ‘solar system’ model is based on the idea of a high plasticity of haematopoiesis and an intimate relationship Peripheral blood between various types of progenitor cells.* Many progenitors share common transcription factors. The proximity of radial sectors of different cell Megakaryocyte lineages depicts how close the ontogeny of these lineages is. Gradual colour change reflects the potential of early and intermediate progenitors Basophilic to follow different cells’ fates. granulocyte Reticulocyte Reticulated platelet Haematopoietic stem cell Common lymphoid progenitor Granulocyte-monocyte progenitor A true stem cell that has a potential to self-renew The early progenitor committed to lymphoid This intermediate progenitor is committed and differentiate into any lineage of blood cells. lineage. Gives rise to precursors of T and B to monocytic and granulocytic lineages. lymphocytes and natural killer cells. Lymphoid Multipotent progenitor progenitors leave the bone marrow for matu- Megakaryocyte-erythroid progenitor Can give rise to any blood cell lineage. ration in the thymus and lymph nodes. Intermediate progenitor that can only differentiate into a red blood cell or megakaryocyte. Red blood cell Lymphoid-primed multipotent progenitor Common myeloid progenitor Platelet Early progenitor cell that primarily differentiates The early progenitor capable of differenti- Natural killer cell (NK-cell) along the lymphoid lineage. However, the potential ating into any cell of a myeloid lineage, red A type of cytotoxic lymphocyte. ZE001914.EN.N.04/20 to take on myeloid fate is not lost. blood cell or megakaryocyte. * Ceredig R, Rolink AG and Brown G. (2009): Models of haematopoiesis: Seeing the wood for the trees. Nat Rev Immunol. 9(4): 293–300. www.sysmex-europe.com.

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