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Supplemental Data Inter-Individual Variability in Gene Expression DMD #42028 Supplemental data Inter-individual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells Alexandra ROGUE, Carine LAMBERT, Catherine SPIRE, Nancy CLAUDE and André GUILLOUZO Drug and metabolism disposition Supplemental Table 4: Genes more expressed in primary human hepatocyte populations or in HepaRG cells according to the loading plot representation Genes more expressed in primary human hepatocytes (x <-0.03) ANKRD35 ankyrin repeat domain 35 APOC2 apolipoprotein C-II BHMT betaine-homocysteine methyltransferase CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c CGREF1 cell growth regulator with EF-hand domain 1 CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) EFHD1 EF-hand domain family, member D1 FBP1 fructose-1,6-bisphosphatase 1 FTCD formiminotransferase cyclodeaminase GSTP1 glutathione S-transferase pi HGFAC HGF activator IGFALS insulin-like growth factor binding protein, acid labile subunit LDOC1L leucine zipper, down-regulated in cancer 1-like MAGEH1 melanoma antigen family H, 1 ME1 malic enzyme 1, NADP(+)-dependent, cytosolic MTB metallothionein B MUPCDH mucin-like protocadherin OAT ornithine aminotransferase (gyrate atrophy) PIGR polymeric immunoglobulin receptor PRAP1 proline-rich acidic protein 1 PYCARD PYD and CARD domain containing RPS4Y1 ribosomal protein S4, Y-linked 1 RPS4Y2 ribosomal protein S4, Y-linked 2 SERP2 stress-associated endoplasmic reticulum protein family member 2 SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 TMEM45B transmembrane protein 45B UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) VSIG4 V-set and immunoglobulin domain containing 4 DMD #42028 Genes more expressed in HepaRG cells (x >0.03) ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 ACTL8 actin-like 8 AHRR aryl-hydrocarbon receptor repressor ANGPT1 angiopoietin 1 APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C ASAM adipocyte-specific adhesion molecule BTNL8 butyrophilin-like 8 C1QL1 complement component 1, q subcomponent-like 1 CALCR calcitonin receptor CD70 CD70 molecule CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) CDH18 cadherin 18, type 2 CDH19 cadherin 19, type 2 CLEC3B C-type lectin domain family 3, member B COL12A1 collagen, type XII, alpha 1 COL4A6 collagen, type IV, alpha 6 COL8A1 collagen, type VIII, alpha 1 CT45-5 cancer/testis antigen CT45-5 CXCL13 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 DEFB103A defensin, beta 103A DKK1 dickkopf homolog 1 (Xenopus laevis) DNER delta/notch-like EGF repeat containing EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 EGLN3 egl nine homolog 3 (C. elegans) FSTL5 follistatin-like 5 GAGE7 G antigen 7 GGT5 gamma-glutamyltransferase 5 GLI3 GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) GPM6B glycoprotein M6B GPR87 G protein-coupled receptor 87 HOXB9 homeobox B9 HOXC9 homeobox C9 IL13RA2 interleukin 13 receptor, alpha 2 IL1RL1 interleukin 1 receptor-like 1 ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16 KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 KLRC2 killer cell lectin-like receptor subfamily C, member 2 KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) KRT6C keratin 6C LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy) LEPREL1 leprecan-like 1 LPHN3 latrophilin 3 LPL lipoprotein lipase DMD #42028 LUM lumican LUZP4 leucine zipper protein 4 MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) MAGEA12 melanoma antigen family A, 12 MAGEA2B melanoma antigen family A, 2B MAGEA4 melanoma antigen family A, 4 MAGEC2 melanoma antigen family C, 2 MUC15 mucin 15, cell surface associated MYBPH myosin binding protein H NBEA neurobeachin NLGN1 neuroligin 1 NRXN3 neurexin 3 NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 NXF2 nuclear RNA export factor 2 NXF5 nuclear RNA export factor 5 P704P prostate-specific P704P PCDH7 protocadherin 7 PDPN podoplanin PEG10 paternally expressed 10 PLAC8 placenta-specific 8 PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 PTN pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) S100A2 S100 calcium binding protein A2 SCGB1D1 secretoglobin, family 1D, member 1 SCGN secretagogin, EF-hand calcium binding protein SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E SLC47A2 solute carrier family 47, member 2 SOD3 superoxide dismutase 3, extracellular SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 SPANXB2 SPANX family, member B2 SPANXD SPANX family, member D TEX11 testis expressed 11 TUSC3 tumor suppressor candidate 3 VCX variable charge, X-linked VCX3A variable charge, X-linked 3A WDR21C WD repeat domain 21C WISP2 WNT1 inducible signaling pathway protein 2 XAGE1D X antigen family, member 1D ZNF415 zinc finger protein 415 .
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