ABC transporter expression in human placenta as a function of pregnancy condition Cifford W. Mason1, Irina A. Buhimschi, Catalin S. Buhimschi, Yafeng Dong, Carl P. Weiner, and Peter W. Swaan DRUG METABOLISM AND DISPOSITION ID Gene.Title Gene.Symbol FoldΔ p-value 230746_s_at Stanniocalcin 1 STC1 4.0 0.02 223484_at chromosome 15 open reading frame 48 C15orf48 3.6 0.05 210755_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF 2.8 0.00 225895_at synaptopodin 2 SYNPO2 2.7 0.03 212942_s_at KIAA1199 KIAA1199 2.7 0.05 214471_x_at luteinizing hormone beta polypeptide LHB 2.6 0.04 229896_at CDNA clone IMAGE:6106200 --- 2.6 0.00 37512_at hydroxysteroid (17-beta) dehydrogenase 6 homolog (mousHSD17B6 2.6 0.01 226769_at fin bud initiation factor FIBIN 2.6 0.00 204597_x_at stanniocalcin 1 STC1 2.6 0.04 210997_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF 2.5 0.03 205700_at hydroxysteroid (17-beta) dehydrogenase 6 homolog (mousHSD17B6 2.4 0.02 1558397_at CDNA FLJ34100 fis, clone FCBBF3007597 --- 2.2 0.00 205547_s_at transgelin TAGLN 2.2 0.04 1568765_at serpin peptidase inhibitor, clade E (nexin, plasminogen act SERPINE1 2.2 0.00 207558_s_at paired-like homeodomain 2 PITX2 2.2 0.00 236984_at chromosome 4 open reading frame 26 C4orf26 2.2 0.01 202934_at hexokinase 2 HK2 2.2 0.05 206595_at cystatin E/M CST6 2.1 0.01 207995_s_at C-type lectin domain family 4, member M CLEC4M 2.1 0.03 222816_s_at zinc finger, CCHC domain containing 2 ZCCHC2 2.1 0.01 212962_at synapse defective 1, Rho GTPase, homolog 1 (C. elegans SYDE1 2.1 0.05 1555724_s_at transgelin TAGLN 2.1 0.04 209125_at keratin 6A /// keratin 6C KRT6A /// KRT6C 2.1 0.01 200974_at actin, alpha 2, smooth muscle, aorta ACTA2 2.1 0.02 209189_at v-fos FBJ murine osteosarcoma viral oncogene homolog FOS 2.1 0.05 242625_at radical S-adenosyl methionine domain containing 2 RSAD2 2.1 0.02 210287_s_at fms-related tyrosine kinase 1 (vascular endothelial growth fFLT1 2.1 0.04 228850_s_at ------2.1 0.01 243140_at Actin, alpha 2, smooth muscle, aorta ACTA2 2.1 0.04 213747_at ------2.0 0.01 230130_at Slit homolog 2 (Drosophila) SLIT2 2.0 0.03 231169_at Taxilin alpha TXLNA 2.0 0.01 221900_at collagen, type VIII, alpha 2 COL8A2 2.0 0.01 210481_s_at C-type lectin domain family 4, member M CLEC4M 2.0 0.01 210064_s_at uroplakin 1B UPK1B 2.0 0.03 203770_s_at steroid sulfatase (microsomal), isozyme S STS 2.0 0.03 212915_at PDZ domain containing RING finger 3 PDZRN3 2.0 0.04 219232_s_at egl nine homolog 3 (C. elegans) EGLN3 2.0 0.01 203650_at protein C receptor, endothelial (EPCR) PROCR 2.0 0.00 210998_s_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF 2.0 0.01 240314_at Full length insert cDNA clone ZE12G01 --- 2.0 0.02 214182_at ADP-ribosylation factor 6 ARF6 1.9 0.04 243993_at ------1.9 0.02 239365_at Full-length cDNA clone CS0DI027YJ20 of Placenta Cot 25 --- 1.9 0.02 203769_s_at steroid sulfatase (microsomal), isozyme S STS 1.9 0.02 209897_s_at slit homolog 2 (Drosophila) SLIT2 1.9 0.02 231067_s_at Transcribed locus --- 1.9 0.01 205919_at hemoglobin, epsilon 1 HBE1 1.9 0.03 225894_at synaptopodin 2 SYNPO2 1.9 0.05 203592_s_at follistatin-like 3 (secreted glycoprotein) FSTL3 1.9 0.04 231152_at Hypothetical protein FLJ20309 FLJ20309 1.9 0.05 214701_s_at fibronectin 1 FN1 1.9 0.02 205543_at heat shock 70kDa protein 4-like HSPA4L 1.9 0.01 210065_s_at uroplakin 1B UPK1B 1.9 0.04 201058_s_at myosin, light chain 9, regulatory MYL9 1.9 0.03 213797_at radical S-adenosyl methionine domain containing 2 RSAD2 1.9 0.03 204368_at solute carrier organic anion transporter family, member 2A SLCO2A1 1.9 0.01 228582_x_at Transcribed locus --- 1.9 0.05 203768_s_at steroid sulfatase (microsomal), isozyme S STS 1.9 0.01 202068_s_at low density lipoprotein receptor (familial hypercholesterolemLDLR 1.9 0.00 203153_at interferon-induced protein with tetratricopeptide repeats 1 IFIT1 1.9 0.01 1554012_at R-spondin 2 homolog (Xenopus laevis) RSPO2 1.8 0.00 205282_at low density lipoprotein receptor-related protein 8, apolipoprLRP8 1.8 0.00 243847_at Transcribed locus --- 1.8 0.05 204254_s_at vitamin D (1,25- dihydroxyvitamin D3) receptor VDR 1.8 0.00 201185_at HtrA serine peptidase 1 HTRA1 1.8 0.05 228707_at claudin 23 CLDN23 1.8 0.01 242856_at CDNA FLJ10247 fis, clone HEMBB1000705 --- 1.8 0.03 200832_s_at stearoyl-CoA desaturase (delta-9-desaturase) SCD 1.8 0.00 209961_s_at hepatocyte growth factor (hepapoietin A; scatter factor) HGF 1.8 0.05 210986_s_at tropomyosin 1 (alpha) TPM1 1.8 0.04 229943_at tripartite motif-containing 13 TRIM13 1.8 0.03 222853_at fibronectin leucine rich transmembrane protein 3 FLRT3 1.7 0.02 228635_at protocadherin 10 PCDH10 1.7 0.05 231101_at Transcribed locus --- 1.7 0.01 204952_at LY6/PLAUR domain containing 3 LYPD3 1.7 0.02 220595_at PDZ domain containing RING finger 4 PDZRN4 1.7 0.03 227480_at sushi domain containing 2 SUSD2 1.7 0.00 209406_at BCL2-associated athanogene 2 BAG2 1.7 0.05 204955_at sushi-repeat-containing protein, X-linked SRPX 1.7 0.02 1556194_a_at CDNA FLJ33585 fis, clone BRAMY2012163 --- 1.7 0.05 216396_s_at etoposide induced 2.4 mRNA EI24 1.7 0.02 202314_at cytochrome P450, family 51, subfamily A, polypeptide 1 CYP51A1 1.7 0.01 205648_at wingless-type MMTV integration site family member 2 WNT2 1.7 0.04 224009_x_at dehydrogenase/reductase (SDR family) member 9 DHRS9 1.7 0.03 217550_at activating transcription factor 6 ATF6 1.7 0.00 203951_at calponin 1, basic, smooth muscle CNN1 1.7 0.01 208614_s_at filamin B, beta (actin binding protein 278) FLNB 1.7 0.00 211138_s_at kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) KMO 1.7 0.03 203637_s_at midline 1 (Opitz/BBB syndrome) MID1 1.7 0.00 203767_s_at steroid sulfatase (microsomal), isozyme S STS 1.7 0.04 1566140_at homeodomain-only protein HOP 1.7 0.01 206249_at mitogen-activated protein kinase kinase kinase 13 MAP3K13 1.7 0.00 228955_at Transcribed locus --- 1.7 0.01 225491_at solute carrier family 1 (glial high affinity glutamate transpor SLC1A2 1.7 0.05 205306_x_at kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) KMO 1.6 0.04 203990_s_at ubiquitously transcribed tetratricopeptide repeat, X chromo UTX 1.6 0.03 209682_at Cas-Br-M (murine) ecotropic retroviral transforming sequenCBLB 1.6 0.01 210881_s_at insulin-like growth factor 2 (somatomedin A) /// insulin- insuIGF2 /// INS-IGF 1.6 0.00 203304_at BMP and activin membrane-bound inhibitor homolog (XenoBAMBI 1.6 0.02 208613_s_at filamin B, beta (actin binding protein 278) FLNB 1.6 0.00 208433_s_at low density lipoprotein receptor-related protein 8, apolipoprLRP8 1.6 0.01 229465_s_at Transcribed locus, moderately similar to XP_001102724.1 --- 1.6 0.02 207172_s_at cadherin 11, type 2, OB-cadherin (osteoblast) CDH11 1.6 0.05 213004_at angiopoietin-like 2 ANGPTL2 1.6 0.01 211000_s_at interleukin 6 signal transducer (gp130, oncostatin M receptIL6ST 1.6 0.05 211103_at myosin VIIA MYO7A 1.6 0.01 237732_at ------1.6 0.05 224252_s_at FXYD domain containing ion transport regulator 5 FXYD5 1.6 0.01 207978_s_at nuclear receptor subfamily 4, group A, member 3 NR4A3 1.6 0.00 222451_s_at zinc finger, DHHC-type containing 9 ZDHHC9 1.6 0.03 204864_s_at interleukin 6 signal transducer (gp130, oncostatin M receptIL6ST 1.6 0.04 209747_at transforming growth factor, beta 3 TGFB3 1.6 0.02 209535_s_at ------1.6 0.05 201995_at exostoses (multiple) 1 EXT1 1.6 0.01 222847_s_at egl nine homolog 3 (C. elegans) EGLN3 1.6 0.01 239227_at ------1.6 0.01 235150_at MRNA; cDNA DKFZp313B1017 (from clone DKFZp313B10--- 1.6 0.03 226621_at ------1.6 0.02 214452_at branched chain aminotransferase 1, cytosolic BCAT1 1.6 0.04 205431_s_at bone morphogenetic protein 5 BMP5 1.6 0.05 205729_at oncostatin M receptor OSMR 1.6 0.05 1552947_x_at zinc finger protein 114 ZNF114 1.6 0.02 223952_x_at dehydrogenase/reductase (SDR family) member 9 DHRS9 1.6 0.03 218084_x_at FXYD domain containing ion transport regulator 5 FXYD5 1.6 0.02 222288_at Transcribed locus, moderately similar to XP_517655.1 sim--- 1.6 0.02 1557918_s_at solute carrier family 16, member 1 (monocarboxylic acid traSLC16A1 1.6 0.03 243917_at chloride intracellular channel 5 CLIC5 1.6 0.00 213317_at chloride intracellular channel 5 CLIC5 1.6 0.02 218454_at hypothetical protein FLJ22662 FLJ22662 1.6 0.00 210665_at tissue factor pathway inhibitor (lipoprotein-associated coagTFPI 1.5 0.05 203974_at haloacid dehalogenase-like hydrolase domain containing 1HDHD1A 1.5 0.04 233219_at CDNA FLJ13365 fis, clone PLACE1000332 --- 1.5 0.03 213001_at angiopoietin-like 2 ANGPTL2 1.5 0.01 239901_at Transcribed locus --- 1.5 0.04 202195_s_at transmembrane emp24 protein transport domain containingTMED5 1.5 0.02 213746_s_at filamin A, alpha (actin binding protein 280) FLNA 1.5 0.01 218772_x_at transmembrane protein 38B TMEM38B 1.5 0.01 228706_s_at claudin 23 CLDN23 1.5 0.05 223275_at protein arginine methyltransferase 6 PRMT6 1.5 0.05 210126_at pregnancy specific beta-1-glycoprotein 9 PSG9 1.5 0.02 238419_at pleckstrin homology-like domain, family B, member 2 PHLDB2 1.5 0.03 218729_at latexin LXN 1.5 0.01 227870_at neighbor of Punc E11 NOPE 1.5 0.00 204636_at collagen, type XVII, alpha 1 COL17A1 1.5 0.05 204686_at insulin receptor substrate 1 IRS1 1.5 0.03 218948_at glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 QRSL1 1.5 0.00 214580_x_at keratin 6A /// keratin 6B /// keratin 6C KRT6A /// KRT6B 1.5 0.00 239286_at Transcribed locus --- 1.5 0.02 1556055_at Clone 23574 mRNA sequence --- 1.5 0.04 228702_at hypothetical protein FLJ43663 FLJ43663 1.5 0.05 213446_s_at IQ motif containing GTPase activating protein 1 IQGAP1 1.5 0.03 232525_at CDNA: FLJ21429 fis, clone COL04205 --- 1.5 0.03 211083_s_at mitogen-activated protein kinase kinase kinase 13 MAP3K13 1.5 0.01 230100_x_at p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeasPAK1 1.5 0.02 227419_x_at placenta-specific 9 PLAC9 1.5 0.03 235684_s_at sestrin 3 SESN3 1.5 0.00 228156_at Homo sapiens, clone IMAGE:4346533, mRNA --- 1.5 0.05 219648_at melanoregulin MREG 1.5 0.03 36552_at hypothetical protein DKFZP586P012 1.5 0.05 219191_s_at bridging integrator 2 BIN2 1.5 0.02 233260_at CDNA FLJ13528 fis, clone PLACE1006143 --- 1.5 0.04 207543_s_at procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline P4HA1 1.5 0.02 201411_s_at pleckstrin homology domain containing, family B (evectins)PLEKHB2 1.5 0.00 1554593_s_at solute carrier family 1 (high affinity aspartate/glutamate tranSLC1A6 1.5 0.01 220029_at elongation of very long chain fatty acids (FEN1/Elo2, SUR4ELOVL2 1.5 0.01 209967_s_at cAMP responsive element modulator CREM 1.5 0.01 203636_at midline 1 (Opitz/BBB syndrome) MID1 1.5 0.01 217294_s_at enolase 1, (alpha) ENO1 1.5 0.05 214539_at serpin peptidase inhibitor, clade B (ovalbumin), member 10SERPINB10 1.5 0.00 228234_at toll-like receptor adaptor molecule 2 TICAM2 1.5 0.02 220949_s_at chromosome 7 open reading frame 49 C7orf49 1.5 0.00 235539_at Nuclear mitotic apparatus protein 1 NUMA1 1.5 0.04 200859_x_at filamin A, alpha (actin binding protein 280) FLNA 1.5 0.02 240271_at Transcribed locus --- 1.5 0.05 1557100_s_at HECT domain containing 1 HECTD1 1.5 0.03 216504_s_at solute carrier family 39 (zinc transporter), member 8 SLC39A8 1.5 0.04