NPDCH Subject Code: 1DS1010204 Subject Title: Oral Pathology and Oral Microbiology Pre-Requisite Subject

Total Page:16

File Type:pdf, Size:1020Kb

NPDCH Subject Code: 1DS1010204 Subject Title: Oral Pathology and Oral Microbiology Pre-Requisite Subject NPDCH Subject Code: 1DS1010204 Subject Title: Oral Pathology and Oral Microbiology Pre-requisite Subject - NONE - Teaching Scheme (Hours per Evaluation Scheme (Marks) week) Theory(T) Practical (P) Viva University Continuous Total Lecture Tutorial Practical Credit University Continuous Voce Total Assessment Assessment Marks Assessment Assessment Marks 90 10 100 2 -- 2 -- 70 10 20 100 Topics for III Year Description 1. Classification of Odontogenic, Etiopathogenesis, BENIGN AND clinical features, histopathology, radiological MALIGNANT features & laboratory diagnosis (as appropriate) ODONTOGENIC of the following common tumours :- - - TUMOURS OF Odontogenic tumours -Classification Benign ORAL CAVITY a. Odontogenic epithelium without odontogenic ectomesenchyme Ameloblastoma, Calcifying Epithelial OdontogenicTumour,AdenomatoidOdonto genicTumour,SquamousOdontogenictumo ur b. Odontogenic epithelium with Odontogenic ectomesenchyme Ameloblastic fibroma, Ameloblastic fibroodontoma, Odontoma, Dentinogenic Ghost cell Tumour c. Odontogenic ectomesenchyme with or without included odontogenic epithelium- Peripheral and Central odontogenic fibroma, Odontogenic Myxoma, Benign ceme ntoblastoma Malignant a. Odontogenic carcinomas: Metastasizing ameloblastoma, Ameloblastic carcinoma FDS, SPU-Visnagar NPDCH 2. BENIGN AND Classification of Non-Odontogenic Tumours MALIGNANT - Non-odontogenic NON- a.- Benigntumours of epithelial tissue origin ODONTOGENIC -Papilloma, Keratoacanthoma, Nevus TUMOURS OF b.- Premalignant lesions and conditions: ORAL CAVITY Definition, Classification -Epithelial dysplasia -Leukoplakia, Carcinoma in situ, Erythroplakia, Oral submucous fibrosis c. Malignant tumors of epithelial tissue origin -Basal cell carcinoma, Epidermoid carcinoma (Epidemiology, etiology, clinical& histological features, Grading and TNM staging),Verrucous carcinoma, Malignant melanoma, Recent advances in diagnosis , management and prevention of Oral cancer d. -Benign tumours of Connective tissue origin -Fibroma, Giant cell fibroma, Peripheral and Central ossifying fibroma, Lipoma, Haemangioma (different types), Lymphangioma,Chondroma,Osteoma,Osteoi dosteoma,Benignosteoblastoma,Tori and Multiple exostosese. Tumour like lesions of Connective tissue origin-,Peripheral ossifying fibroma e-Malignant tumours of Connective tissue origin - Fibrosarcoma,Chondrosarcoma,Kaposi’ssarc oma,Ewing’ssarcoma,Osteosarcoma,Hodgkin ’s and Non Hodgkin’s lymphoma, Burkitt’slymphoma, Multiplemyeloma, Solitary Plasma cell myeloma f-.Benigntumours of Muscle tissue origin - Leiomyoma,Rhabdomyoma,Congenital Epulis of newborn, Granular cell tumour g. Benign and Malignant tumours of Nerve tissue origin -Neurofibroma and Neurofibromatosis , Schwannoma, Melanotic neuroectodermal tumour of infancy, Malignant Schwannoma. h. Metastatic tumours of Jaws and Soft tissues of Oral cavity FDS, SPU-Visnagar NPDCH BENIGN AND Classification of Salivary Gland Tumours 3. MALIGNANT Salivary Gland Benign neoplasms - Pleomorphic SALIVARY Adenoma, Warthin'stumour, &Oncocytoma. GLAND Malignant neoplasms –Malignant Pleomorphic TUMOURS adenoma Adenoid Cystic Carcinoma, Mucoepidermoid Carcinoma, Acinic Cell Carcinoma & Adenocarcinomas 4. CYSTS OF THE Classification, etiopathogenesis, clinical features, ORAL & histopathology, laboratory & radiological features PARAORAL (as appropriate) of Odontogenic cysts- REGION Odontogenickeratocyst,Dentigerouscyst,Primordi alcyst,Dental lamina cyst of newborn,Gingival cyst of adults,Lateral periodontal cyst,Calcifyingodontogeniccyst,Radicular cyst Non-Odontogenic cysts- Pseudocysts of jaws,Aneurysmal bone cyst,Traumatic bone cyst & soft tissue cysts of oral &paraoral region. 5. NON Sialolithiasis, Sialosis, Sialadenitis, Xerostomia NEOPLASTIC & Ptyalism. Sjogren’s syndrome ,Benign SALIVARY lymphoepithelial lesion, Necrotizing GLAND sialometaplasia DISEASES : 6. MICROBIAL Microbiology, defence mechanisms including INFECTIONS OF immunological aspects, oral manifestations, ORAL SOFT histopathogy and laboratory diagnosis of common TISSUES bacterial, viral & fungal infections namely :- Bacterial : Scarlet fever, Diphtheria, Tuberculosis, Syphilis, Actinomycoses& its complications – Cancrum Oris, Tetanus, Noma . Viral :Herpes Simplex, Varicella zoster, Measles, Mumps & HIV infection and Oral manifestation of AIDS. Fungal: Candidiasis, Histoplasmosis Immunological diseases: Recurrent Aphthous FDS, SPU-Visnagar NPDCH stomatitis, Bechet’s syndrome, Reiter’s syndrome, Sarcoidosis. 7. COMMON Etiopathogenesis, clinical features, radiological & NONINFLAMMA laboratory values in diagnosis of: Fibrous TORY DISEASES dysplasia, Cherubism, Osteogenesis Imperfecta, INVOLVING Paget's bone disease, Cleidocranial dysplasia, THE JAWS Rickets, Achondroplasia, Marfan's syndrome , Down's syndrome and Histiocytosis X disease. 8. BIOPSY,CYTOL Factors affecting healing of wounds -healing of OGY AND extraction wound and Dry socket Biopsy- HEALING OF techniques, Healing of biopsy wound -Exfoliative ORAL WOUNDS cytology-Indications, Staining and Interpretation 9. SYSTEMIC Brief review & oral manifestations, diagnosis & DISEASES significance of common Blood, Nutritional, INVOLVING Hormonal & Metabolic diseases of Oral cavity. ORAL CAVITY a. Blood dyscrasias- Clinico-pathological aspects and oral manifestations of Anemias, Polycythemia, Leukopenia, Neutropenia, Agranulocytosis, ChediakHigashi syndrome, Leukocytosis, Infectiousmononucleosis, Leukemias, Purpura Haemophilia b.Oral aspects of Disturbances in mineral metabolism c.Oral aspects of Avitaminosis and Hypervitaminoses d.Oral Aspects of Endocrine dysfunction 10. MUCOCUTANE Etiopathogenesis, clinical features & OUS LESIONS histopathology of the following common lesions. Lichen Planus, Lupus Erythematosus, Pemphigus &Pemphigoid lesions, Erythema Multiforme, Psoriasis, Scleroderma, Ectodermal Dysplasia, Epidermolysis bullosa& White sponge nevus. 11. PERIODONTAL Stains, Calculus, Dental plaque Etiopathogenesis, DISEASES microbiology, clinical features, histopathology & radiological features (as appropriate) of gingivitis, gingival enlargements ,ANUG, chronic desquamative gingivitis periodontitis and juvenile periodontitis. Basic immunological mechanisms of periodontal disease to be highlighted. 12. DISEASES OF Ankylosis, luxation and subluxation, summary of TM JOINT different types of arthritis & other developmental malformations, traumatic injuries & myofascial pain dysfunction syndrome 13. DISEASES OF Facial neuralgias – Trigeminal, Sphenopalatine & THE NERVES Glossopharyngeal neuralgias, VII nerve paralysis, FDS, SPU-Visnagar NPDCH Causalgia Psychogenic facial pain & Burning mouth syndrome. 14. PIGMENTATION Pigmentation of Oral & Paraoral region & OF ORAL Discolouration of teeth: Causes & clinical TISSUES manifestations. 15. DISEASES OF Traumatic injuries to sinus, Sinusitis, Cysts & MAXILLARY Tumours involving antrum SINUS 16 PRINCIPLES OF Introduction, definition, aims & scope. Sex and BASIC ethnic (racial) differences in tooth morphology FORENSIC and histological age estimation Determination of ODONTOLOGY sex & blood groups from buccal mucosa / saliva. Dental DNA methods Bite marks, rugae patterns & lip prints Dental importance of poisons and corrosives Overview of forensic medicine and toxicology LABORATORY/PRACTICAL REQUIREMENTS Students have to maintain records of laboratory procedures/work done/report of practical: Oral Pathology and Microbiology Identification of the pathologic features of: Microdontic tooth, Macrodontic tooth, Gemination of tooth, Fused teeth, Concrescence of tooth, Dilaceration, Dens in dente, Dens evaginatus, Supernumerary root, Hypoplastic enamel, Fluorosis, Abrasion, Attrition, Fracture tooth, Hypercementosis Histopathologic Examination of the following gross specimens: Papilloma, Fibroma, Torus, Carcinoma of oral structures, Salivary Gland Tumours, Ameloblastoma, Periapical Granuloma,Dentigerous Cyst, Pulp Polyp. Microbiologic Examination of: Tuberculosis, Actinomycosis, Syphilis, Candidiasis Histopathologic Slides of: 1) Odontogenic tumors 2) Non odontogenic tumors 3) Salivary gland tumors. 4) Odontogenic cysts 5) Microbial diseases 6) Bone lesions 7) Mucocutaneous lesions 8) Dental caries 9) Pulp and periapical lesions FDS, SPU-Visnagar .
Recommended publications
  • ADEA Compendium of Curriculum Guidelines Allied Dental Education
    ADEA Compendium of Curriculum Guidelines (Revised Edition) Allied Dental Education Programs May 2015–2016 ADEA Compendium of Curriculum Guidelines for Allied Dental Education Programs May 2015–2016 CONTENTS INTRODUCTION .................................................................................................. 2 ACKNOWLEDGEMENTS ...................................................................................... 5 DENTAL HYGIENE CURRICULUM GUIDELINES ................................................... 8 Clinical and Preclinical Dental Hygiene ........................................................... 8 Community Dental Health ............................................................................. 21 Dental Materials ............................................................................................ 31 Medical Emergencies .................................................................................... 53 Nutrition ........................................................................................................ 60 Oral Anatomy and Histo-embryology ............................................................ 70 Oral Pathology............................................................................................... 97 Periodontology ............................................................................................ 109 Pharmacology .............................................................................................. 125 Research for Dental Hygiene Education .....................................................
    [Show full text]
  • COMPENDIUM of CURRICULUM GUIDELINES (Revised Edition)
    COMPENDIUM OF CURRICULUM GUIDELINES (Revised Edition) ALLIED DENTAL EDUCATION PROGRAMS February 2005 TABLE OF CONTENTS Introduction…………………………………………………………………………….3 Acknowledgments…………………………………………………………………….6 DENTAL HYGIENE CURRICULUM GUIDELINES Clinical Dental Hygiene……………………………………………………………...10 Community Dental Health…………………………………………………………...21 Dental Materials……………………………………………………………………….28 Medical Emergencies……………………………………………………………….. 49 Nutrition……………………………………………………………………………….. 55 Oral and Facial Anatomy…………………………………………………………….65 Oral Pathology…………………………………………………………………………88 Periodontology……………………………………………………………..................98 Pharmacology…………………………………………………………………………110 Research………………………………………………………………………………..123 Special Needs Patients………………………………………………………………129 DENTAL ASSISTING CURRICULUM GUIDELINES Pathology……………………………………………………………………………….137 Preclinical Dental Assisting…………………………………………………………145 DENTAL HYGIENE AND DENTAL ASSISTING CURRICULUM GUIDELINES Dental Radiography……………………………………………………………………152 Radiation Use Guidelines……………………………………………………………..173 Clinical Radiology………………………………………………………………………178 Ethics and Professionalism…………………………………………………………..184 2 INTRODUCTION This document is a revision of curriculum guidelines that were developed for allied dental education programs between 1984 and 1994. It does not include all content areas that could be found in an allied dental education program. Most of the guidelines are for dental hygiene with some for dental assisting. Unfortunately, no guidelines were developed during this time
    [Show full text]
  • Poster Communications
    1113-5181/19/27.1/94-120 ODONTOLOGÍA PEDIÁTRICA ODONTOL PEDIÁTR (Madrid) COPYRIGHT © 2019 SEOP Y ARÁN EDICIONES, S. L. Vol. 27, N.º 1, pp. 94-120, 2019 Poster communications RESEARCH STUDIES 10. CHANGES IN ORAL HEALTH-RELATED QUALITY OF LIFE WHEN ASSOCIATED WITH THE TYPE OF CLEFT LIP AND/OR PALATE IN SURGICALLY TREATED CHILDREN 8. EFFECT OF INHALED MEDICATION ON THE López Ramos, R.P.1; Abanto, J.2; Blanco, D.3; Torres, ORAL HEALTH OF ASTHMATIC PATIENTS G.4; Pajuelo, M.3 1 1 2 3 4 Faculty of Public Health and Administration. Peruvian Pinto, V. ; Menor, A. ; Gallegos, L. ; Martínez, E. 2 1Clínica Pinto. Burgos. 2Centro de Salud de Coria. Cáceres. University of Cayetano Heredia. Lima, Peru. Department 3 4 of Pediatric Dentistry. University of São Paulo. São Alfonso X El Sabio University. Madrid. Complutense 3 University of Madrid. Madrid Paulo, Brasil. Faculy of Sciences and Philosophy. Peruvian University Cayetano Heredia. Lima, Peru. 4 Introduction and objectives: Currently, and with increasing Postgraduate course on Pediatric Dentistry. Faculty of frequency, respiratory disorders are affecting a large percen- Pediatric Dentistry. National University of San Marcos. tage of the child population. The literature reviewed in this Lima, Peru research project shows that the use of inhaled medication for respiratory conditions is related to adverse reactions such as Introduction and objectives: The most common cranio- erosion, dental caries, gingivitis, halitosis or xerostomia. The facial malformation in children is the cleft lip and/or palate objective of the present study was to evaluate the relations- and the treatment is multidisciplinary.
    [Show full text]
  • TV's COMPLIED NDBE QUESTIONS 2013‐2015
    TV’s COMPLIED NDBE QUESTIONS 2013‐2015 https://quizlet.com/87020251/stuff‐to‐remember‐flash‐cards/ Compiled + 2015 + notes = purple + Highlighted FUNGI *A chlamydospore is the thick‐walled big resting spore of several kinds of fungi, including Ascomycota such as Candida and Basidiomycota such as Panus. It is the life‐stage which survives in unfavourable conditions, such as dry or hot seasons. 1. Organisms that exhibit dimorphism and grow on Sabouraud's medium (low pH): Fungi 2. Type of agar used for most fungi? Sabouraud agar 3. Organism that causes athletes foot (tinea pedis) Trichophyton 4. Which fungal infection leads to superficial skin disease? Trichophyton ‐ Epidermophyton & Microsporum cause dermatophytosis. Tx w/ Griseofulvin 5. Which fungus causes cerebral/brain infarct? a. Cryptococcus may spread into the meninges and cause Cryptococcal Meningitis b. Aspergillus causes aspergilloma “fungus ball” in the lungs causing pulmonary infection in ppl with AIDS or have undergone organ transplant c. Mucormycosis Pt’s w/ diabetic ketoacidosis, burns, or leukemia are particularly susceptible. It results in black, dead tissue in the nasal cavity and blocks the blood supply to the brain. ‐ Mucormycosis is found in blood vessels (endothelium) & is often related to diabetic pts 6. Aflatoxin is what produced by what fungus? Aspergillus 7. Cell immunity is most important for? Intracellular parasiteow 8. Which one can be seen as an intracellular organism? Histoplasmosis ‐ In infected tissues, yeast cells of Histoplasmosis are found within macrophages. 9. Disseminated fungi? Histoplasmosis (infection by a fungus found in the droppings of birds and bats in humid areas. It is not serious if confined to the lungs but can be fatal if spread throughout the body) 10.
    [Show full text]
  • Description Concept ID Synonyms Definition
    Description Concept ID Synonyms Definition Category ABNORMALITIES OF TEETH 426390 Subcategory Cementum Defect 399115 Cementum aplasia 346218 Absence or paucity of cellular cementum (seen in hypophosphatasia) Cementum hypoplasia 180000 Hypocementosis Disturbance in structure of cementum, often seen in Juvenile periodontitis Florid cemento-osseous dysplasia 958771 Familial multiple cementoma; Florid osseous dysplasia Diffuse, multifocal cementosseous dysplasia Hypercementosis (Cementation 901056 Cementation hyperplasia; Cementosis; Cementum An idiopathic, non-neoplastic condition characterized by the excessive hyperplasia) hyperplasia buildup of normal cementum (calcified tissue) on the roots of one or more teeth Hypophosphatasia 976620 Hypophosphatasia mild; Phosphoethanol-aminuria Cementum defect; Autosomal recessive hereditary disease characterized by deficiency of alkaline phosphatase Odontohypophosphatasia 976622 Hypophosphatasia in which dental findings are the predominant manifestations of the disease Pulp sclerosis 179199 Dentin sclerosis Dentinal reaction to aging OR mild irritation Subcategory Dentin Defect 515523 Dentinogenesis imperfecta (Shell Teeth) 856459 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield I 977473 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield II 976722 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect;
    [Show full text]
  • DH 318 General and Oral Pathology
    DH 248 General and Oral Pathology Spring 2014 Meeting Times: Tuesday & Thursday 10:00 - 11:50 a.m. CASA Mortuary Science Room 70 Credits: 4 credit hours Faculty: Sherri Lukes, RDH, MS, Associate Professor, Room 129 Office: 453-7289 Cell: 521-3392 E-mail: [email protected] Office Hours: Monday 1:00 p.m. - 4:00 p.m. Tuesday 1:00-4:00 Other office hours by appointment COURSE DESCRIPTION: This course has been designed to integrate oral pathology and general pathology. Students will study principles of general pathology with emphasis on the relationships to oral diseases. Pathologic physiology is included such as tissue regeneration, the inflammatory process, immunology and wound healing. Clinical appearance, etiology, location and treatment options of general system diseases is presented, along with the oral manifestations. Special attention will be placed on common pathological conditions of the oral cavity and early recognition of these conditions. DH Competencies addressed in the course: PC.1 Systematically collect analyze, and record data on the general, oral, and psychosocial health status of a variety of patients/clients using methods consistent with medico-legal principles. PC.2 Use critical decision making skills to reach conclusions about the patient’s/client’s dental hygiene needs based on all available assessment data. PC.3 Collaborate with the patient / client, and/or other health professionals, to formulate a com- prehensive dental hygiene care plan that is patient / client-centered and based on current scientific evidence. PC.4 Provide specialized treatment that includes preventive and therapeutic services designed to achieve and maintain oral health. Assist in achieving oral health goals formulated in collaboration with the patient / client.
    [Show full text]
  • 07. COMUNICAC. ORALES MONTADOS 24/7/13 08:31 Página 81
    08. COMUNICACIONES POSTER INGLES:07. COMUNICAC. ORALES MONTADOS 24/7/13 08:31 Página 81 1113-5181/13/21.1/81 ODONTOLOGÍA PEDIÁTRICA ODONTOL PEDIÁTR (Madrid) Copyright © 2013 SEOP Y ARAN EDICIONES , S. A. Vol. 21. N.º 1, pp. 81-93, 2013 Posters Communications INVESTIGATION Conclusions: Bearing in mind the limitations of the study, Murcian school children aged 5-6 years had high luminosity, little chrome and a yellow hue. 1. PREVALENCE OF COLOR IN PRIMARY TEETH. PILOT STUDY 2. RELATIONSHIP BETWEEN THE SIZE OF Martínez Serrano S, Martín Culebras R, Chiva PRIMARY MOLARS AND PREFORMED STEEL García F CROWNS Universidad de Murcia Gallego A, Hurtado V, Beltri P, Tapia JE, Torres L Introduction: There are not very many studies on Universidad Europea de Madrid color in the primary dentition. Nevertheless, having an understanding of the chromatic characteristics of prima - Preformed crowns were introduced by Humphrey in ry teeth, especially those in the anterior region, is 1950. Currently, with developments in technology, important in pediatric dentistry restoration. changes in material, advances in pulp therapy, anesthe - Objectives: To determine the color parameters of sia and behavior, they continue to be the treatment of anterior primary teeth in a group of children aged 5-6 choice for primary teeth with extensive caries, when the years in the region of Murcia. retention and resistance of conventional restorations Material and methods: Vita color was obtained togeth - may be compromised, although zirconium crowns with er with the parameters for luminosity, chrome and hue in better aesthetic results can be found today on the mar - the upper anterior group of teeth of third year preschoolers ket.
    [Show full text]
  • Glossary of Periodontal Terms.Pdf
    THE AMERICAN ACADEMY OF PERIODONTOLOGY Glossary of Periodontal Te rms 4th Edition Copyright 200 I by The American Academy of Periodontology Suite 800 737 North Michigan Avenue Chicago, Illinois 60611-2690 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, or otherwise without the express written permission of the publisher. ISBN 0-9264699-3-9 The first two editions of this publication were published under the title Glossary of Periodontic Terms as supplements to the Journal of Periodontology. First edition, January 1977 (Volume 48); second edition, November 1986 (Volume 57). The third edition was published under the title Glossary vf Periodontal Terms in 1992. ACKNOWLEDGMENTS The fourth edition of the Glossary of Periodontal Terms represents four years of intensive work by many members of the Academy who generously contributed their time and knowledge to its development. This edition incorporates revised definitions of periodontal terms that were introduced at the 1996 World Workshop in Periodontics, as well as at the 1999 International Workshop for a Classification of Periodontal Diseases and Conditions. A review of the classification system from the 1999 Workshop has been included as an Appendix to the Glossary. Particular recognition is given to the members of the Subcommittee to Revise the Glossary of Periodontic Terms (Drs. Robert E. Cohen, Chair; Angelo Mariotti; Michael Rethman; and S. Jerome Zackin) who developed the revised material. Under the direction of Dr. Robert E. Cohen, the Committee on Research, Science and Therapy (Drs. David L.
    [Show full text]
  • SNODENT (Systemized Nomenclature of Dentistry)
    ANSI/ADA Standard No. 2000.2 Approved by ANSI: December 3, 2018 American National Standard/ American Dental Association Standard No. 2000.2 (2018 Revision) SNODENT (Systemized Nomenclature of Dentistry) 2018 Copyright © 2018 American Dental Association. All rights reserved. Any form of reproduction is strictly prohibited without prior written permission. ADA Standard No. 2000.2 - 2018 AMERICAN NATIONAL STANDARD/AMERICAN DENTAL ASSOCIATION STANDARD NO. 2000.2 FOR SNODENT (SYSTEMIZED NOMENCLATURE OF DENTISTRY) FOREWORD (This Foreword does not form a part of ANSI/ADA Standard No. 2000.2 for SNODENT (Systemized Nomenclature of Dentistry). The ADA SNODENT Canvass Committee has approved ANSI/ADA Standard No. 2000.2 for SNODENT (Systemized Nomenclature of Dentistry). The Committee has representation from all interests in the United States in the development of a standardized clinical terminology for dentistry. The Committee has adopted the standard, showing professional recognition of its usefulness in dentistry, and has forwarded it to the American National Standards Institute with a recommendation that it be approved as an American National Standard. The American National Standards Institute granted approval of ADA Standard No. 2000.2 as an American National Standard on December 3, 2018. A standard electronic health record (EHR) and interoperable national health information infrastructure require the use of uniform health information standards, including a common clinical language. Data must be collected and maintained in a standardized format, using uniform definitions, in order to link data within an EHR system or share health information among systems. The lack of standards has been a key barrier to electronic connectivity in healthcare. Together, standard clinical terminologies and classifications represent a common medical language, allowing clinical data to be effectively utilized and shared among EHR systems.
    [Show full text]
  • Pdf Mutations
    Int. J. Biol. Sci. 2018, Vol. 14 381 Ivyspring International Publisher International Journal of Biological Sciences 2018; 14(4): 381-389. doi: 10.7150/ijbs.23517 Research Paper Expanding the Oro-Dental and Mutational Spectra of Kabuki Syndrome and Expression of KMT2D and KDM6A in Human Tooth Germs Thantrira Porntaveetus1, Mushriq F Abid2, Thanakorn Theerapanon3, Chalurmpon Srichomthong4,5, Atsushi Ohazama6, Katsushige Kawasaki6, Maiko Kawasaki6, Kanya Suphapeetiporn4,5, Paul T. Sharpe2, 4,5 Vorasuk Shotelersuk 1. Craniofacial Genetics and Stem Cells Research Group, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand 2. Centre for Craniofacial and Regenerative Biology, Dental Institute, King’s College London, London, SE1 9RT, UK 3. Excellence Center in Regenerative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand 4. Center of Excellence for Medical Genetics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 5. Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok 10330, Thailand 6. Division of Oral Anatomy, Niigata University, Niigata 951-8514, Japan Corresponding author: Dr Thantrira Porntaveetus, Craniofacial Genetics and Stem Cells Research Group, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand. Email: [email protected] © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2017.10.27; Accepted: 2018.02.26; Published: 2018.03.09 Abstract Kabuki syndrome is a rare genetic disorder characterized by distinct dysmorphic facial features, intellectual disability, and multiple developmental abnormalities.
    [Show full text]
  • A Unique Syndrome of Gemination and External/ Internal Root Resorptions in One Dental Arch: a Case Report
    Crimson Publishers Case Report Wings to the Research A Unique Syndrome of Gemination and External/ Internal Root Resorptions in One Dental Arch: A Case Report Pray Nickolas1, Raghavendra Sree2 and Kazemi Reza B3* 1Pediatric Dentistry Resident, UCONN Health School of Dental Medicine, USA 2 ISSN: 2637-7764 Assistant Clinical Professor, UCONN Health School of Dental Medicine, USA 3Associate Professor, UCONN Health School of Dental Medicine, USA Abstract Dental literature, considering a unique syndrome of two distinct developmental disruptions; fusion and or disease in one dental arch was reviewed. gemination teeth and morphological irregularities; external/internal root resorptions caused by trauma The PubMed and Google Scholar citations revealed only one report of fusion and internal resorption in the same arch/tooth. However, the present case report’s dental inquiry revealed a history of a geminated undermaxillary an unusualleft lateral circumstance. incisor tooth The [# 10]clinical in addition and radiograph to a dental analysis trauma of morethese than two 20teeth years revealed ago, where their both teeth [#s 08 & 09] were traumatized. Tooth [# 09] was avulsed and replanted back into dental alveoli *Corresponding author: Kazemi Reza B, enduring involvement with the external/internal root resorptions as well. Patient reported, no other Associate Professor, UCONN Health School of significant past dental history, except routine dental visits and treatments. The clinical and radiographical Dental Medicine, USA wearevaluation, provided findings, as of Falland 2020 diagnosis are also are described. discussed. The proposed treatment plans for management of the unilateral geminated tooth, external/internal root resorptions and clinical problem of severe occlusal Submission: August 08, 2020 Introduction Published: May 03, 2021 Developmental dental disorders and malformed teeth may be due to congenital, inherited, acquired or idiopathic reasons causing anomalies in tooth number, size, shape and structure.
    [Show full text]
  • Primary Double Teeth and Their Effect on Permanent Successors
    Introduction A.Z. Zengin, P. Celenk, K. Gunduz, M. Canger Fusion is a developmental anomaly defined as the union Faculty of Dentistry, Department of Oral and Maxillofacial Radiology of two normally separated tooth buds with the dentins University of Ondokuz Mayis, Turkey at any stage of their development. They may be fused or separated, depending on the development stages of e-mail: [email protected] dental pulp and canal. Tooth gemination is the separation of a single tooth germ. Teeth with large single or bifid crown have a normal root or root canal. As a general rule, when the affected tooth is regarded as one, if in Primary double teeth the arch there is one tooth less than the normal count it is called fusion, while when the normal number of teeth and their effect is present it is termed gemination [Duncan and Helpin, 1987]. However, literature shows that the differential on permanent diagnosis between fusion and gemination is difficult (in some cases, fusion with supernumerary tooth) [Duncan successors and Helpin, 1987; Shafer et al., 1974]. The term “double teeth” is often used to describe both anomalies [Brook and Winter, 1970; Buenviaje and Rapp, 1984; Tasa and Lukacs, 2001]. The prevalence of ABSTRACT double teeth varies between 0.1 and 3% [Duncan and Helpin, 1987; Tasa and Lukacs, 2001]. Double teeth are Aim Understanding the effects of primary double more common in primary than in permanent dentition tooth (PDT) on permanent successors is important to (0.6% of primary dentition and 0.1% of permanent ensure healthy permanent occlusion and aesthetics.
    [Show full text]