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Vol. 14 No. 14/Dec. 7, 1989

New compounds hold promise AIDS virus replication may be blocked A newly developed class of com- pounds has proven to effectively inhibit replication of the AIDS virus in cultured human white blood cells and might hold promise as a new thera- peutic approach to this disease, according to researchers at the School of Medicine. The scientists' findings appear in the current issue of The Proceedings of the National Academy of Sciences, a highly regarded re- search journal. "While these results are exciting, it's important to point out that the studies described in the report were limited only to testing in cell cultures. We must temper our enthusiasm until more is known," says Jeffrey I. Gordon, M.D., principal investigator and professor of medicine and of biochemistry and molecular biophys- ics who directed the research. "Considerably more work has to be done with cultured cells and in animals before we completely under- stand how these compounds work Lonnie Haefner, Ph.D., professor of civil engineering, points out slipshod maintenance of a parapet joist on a pedestrian/road bridge in St. Louis County. and whether or not they will be useful Haefner says that at least 43 percent of the nearly 600,000 bridges in the United States are maintained poorly, and thus unsafe. in treating viral illnesses such as AIDS." The new compounds resemble myristic acid, a rare, naturally occur- Frequent failures ring fatty acid that appears to be key to the replication of some viruses, for U.S. bridges unsafe due to poor funding, says Lonnie Haefner example, the AIDS virus. After infect- ing a cell, viruses commandeer the The San Francisco Earthquake of 1989 nation's infrastructure. "Many struc- ments or to drop underwater divers to cell's protein-producing machinery gave sobering proof of what excessive tural specialists warn that visual tests determine the strength of substruc- and use it to produce their own stress can do to bridges. But it also don't reveal hidden problems in the tures. The states have to get their acts protein building blocks. Myristic acid serves as a vivid reminder of the structure; they're often very inaccu- together before the whole system is must be linked to some of these deteriorating condition of our nation's rate." out of control." proteins in order for them to be bridges and highways, says Lonnie Money is at the core of the incorporated into an intact virus. Haefner, Ph.D., professor of civil Substructures ignored problem. Haefner cites a 20 percent More startling than the seemingly Thus, viral replication is dependent on engineering. reduction in federal dollars to the linkage of myristic acid to viral "The condition of bridges and casual inspection of bridges is the Federal Highway Program between disregard for the substructure of a proteins. the state of their funding in the United 1982 and 1987, a decline from $2 Scientists in Gordon's lab have States is so bad that if we were a bridge — the part that is often hidden billion per year to $1.6 billion per by water. According to Lee Dickinson, been studying the enzyme N-myris- Third World country, we'd go to the year, prompted by the government's toyltransferase, which links myristic World Bank for a loan," says the Ph.D., a civil engineer who is a need to reduce annual spending. It is member of the National Transporta- acid to specific viral and cellular transportation engineer. estimated that the United States needs proteins. The new compounds they At least 43 percent of the nearly tion Board in Washington, D.C., $54 billion over the next decade to several of the country's biggest bridge have synthesized are structurally 600,000 bridges in the United States maintain its bridges, amounting to similar to myristic acid, yet have failures this decade involved break- are poorly maintained, and thus $5.4 billion per year. different chemical and physical unsafe, Haefner says. A specialist in downs in the riprap, a concrete and The federal emphasis on trans- stone foundation beneath the water, properties. The enzyme "recognizes" infrastructure problems, Haefner portation should shift toward bridge the novel compounds and transfers and other footings. Waterbeds and recently presented a report to the U.S. repair, says Daniel Hanson, president them to some cellular and viral floods disturb and erode these Congress Office of Technology emeritus of the American Road and proteins. Assessment. The report, "Impact of foundations. Transportation Builders Association, of Although states are required to Treatment of cells with these Advanced Technology and Innovation Washington, D.C. mwistic acid analogs significantly inspect the substructure of bridges on Public Works Management and "After more than 30 years of reduces viral replication. At optimal Decision-Making," focuses on ways every five years, an investigation construction, the interstate system is following the Chickasawbogue Bridge concentrations, one myristic acid the United States can plan to improve just about completed," he says, noting analog reduced HIV replication in failure near Mobile, Ala., in 1985 and manage its infrastructure into the that there are less than 800 miles left vitro by approximately 90 percent next century. revealed that 35 states did not rou- of new interstate to be built in the tinely inspect bridge substructure. with no significant toxicity. These As recently as 1987, the Federal country. "The emphasis now should results are quite similar to those seen Highway Administration (FHWA) be going the other way — toward when AZT, the "gold standard" among estimated that 244,000 of the nation's keeping bridges safe. At the rate AIDS drugs, was used in the same 547,000 bridges were considered bridge repair is being funded, it will experimental model. deficient, Haefner says. Of these, "The condition of take 33 years to catch up to where we The research team showed that 131,000 were structurally deficient and bridges and the state should be now." members of this class of fatty acid 112,000 were considered functionally Failures far too frequent analogs also inhibit the replication of obsolete. Furthermore, he cites FHWA of their funding in the Bridge failure is an every-other- another retrovirus — the Moloney figures from 1987 showing that 37,000 United States is so bad murine leukemia virus — which American bridges were not inspected day occurrence in the United States, that if we were a Third with 189 failures in 1988, according to causes leukemia in mice. While one at all during the previous two years. analog worked most effectively Every bridge must be inspected at World country, we'd go Hanson. Failures occur to massive structures spanning the nation's major Continued on p. 3 least every two years, according to to the World Bank for federal law. arteries, such as the Mississippi and The transportation expert blames a loan." Ohio rivers, as well as 70-year-old the high number of unsafe bridges on — Lonnie Haefner single-lane suspension bridges over negligent maintenance due to poor dried-up creek basins. Inside: MEDICAL RECORD Bridge failure can mean a 30-mile funding. Bridges fail, Haefner says, • Heavy drinking males because they are poorly inspected or detour for a farmer carrying grain to the market, or it can mean death, as it might produce long-term toxic not inspected at all. "I think one key reason substruc- effects in their offspring. Page 4 The most common method of tures are commonly ignored is did on April 5, 1987, when two spans of the New York State Thruway (1-90) • People diagnosed with early inspection today is a simple spot because of the generally hasty meas- Parkinson's disease may be able visual test of the pavement and ures of inspection," says Dickinson, bridge over the Schoharie Creek fell 80 feet after a pier collapsed. Ninety to delay onset of disabling structure of bridges. whose agency investigates transporta- symptoms. Page 5 "Experts say there is a 60 percent tion accidents. "But we are stressing minutes later, another pier crumbled. Four passenger cars and one tractor- • Can liver damage caused by chance for error with a visual test," this very important aspect of bridge semitrailer plunged into the creek. chronic hepatitis C, a sometimes says Haefner, who has often testified safety everywhere. We are urging the fatal disease, be treated? Page 6 before Congress on matters of the states to take 'sounding' measure- Continued on p. 2 Bridges — Introductions to new faculty continued from p. 1 Beginning with this issue, the Record social work and social psychology at will feature a weekly series profiling Ten people died. A long list of the University of Michigan, Ann Arbor, new faculty on the Hilltop and inadequacies was cited by the Na- in 1986. Her research interests include Medical campuses. The introductions tional Transportation Safety Board in a health service and psychosocial will include faculty who joined the follow-up investigation, but the main responses to traumatic stresses. Washington University community Nancy Grant, Ph.D., associate cause was eroded substructure, a between January 1989 and September professor of history, comes to Wash- problem state inspectors ignored for 1989. ington from the Dartmouth College years. Engin D. Akarli, Ph.D., associate history department, where she had Prior to the Bay Bridge and 1-880 professor of history, comes to Wash- taught since 1985. She received her Bridge collapses in the October ington from Yarmouk University in bachelor's degree cum laude from earthquake, the nation's worst bridge Irbid, Jordan, where he was senior Smith College in 1971 and her disaster occurred in 1967 when the associate professor of history in the Silver-Bridge collapsed over the Ohio master's and doctorate from the River in West Virginia. Traffic on the Department of Humanities and Social University of Chicago in 1972 and Sciences. He received a bachelor's in bridge had been stalled several 1978, respectively. Her research business administration from Robert minutes, and the structure collapsed includes a study of the employment of College in 1968, a master's in history under the excessive "static load," as blacks in the federal government from the University of Wisconsin, civil engineers term it. Thirty-three between 1940 and 1972. She is the Madison, in 1970, and a master's and people perished. author of TVA and Black Americans: doctorate in Near Eastern history from That tragedy sparked then-Sen. Planning for the Status Quo 1933- Princeton in 1976. A native of Eskise- Jennings Randolph of West Virginia to 1945, published this summer by Lonnie Haefner pinpoints the area of the bridge hir, Turkey, Akarli's research focuses pass legislation requiring the federal Temple University Press. pictured on page 1 that appears to be in need of on post mid-18th-century socio- government to monitor inspection of John W. Keating, Ph.D., assistant an overhaul. political history of the Middle East, the nation's bridges on a regular basis. professor of economics, comes to the concentrating on relations between Local state maintenance inspec- University from George Washington posted bridges on our priority net- central governmental authorities and tors may be doing cursory inspec- University, where he was an assistant works." regional and vocational social groups. professor of economics. He earned his tions, but the data they collect is The program's title refers to its Eleni Bastea, Ph.D., assistant largely uninterpreted or in some cases bachelor's in electrical engineering original goal to repair or replace 1,000 professor of architecture, comes to the falsified, says Transportation Board from Purdue University in 1982 and a bridges for $1 billion. It operates on a University from the College of Envi- member Dickinson. doctorate in economics from North- share of federal funds and a state ronmental Design at the University of "We see many cases of data on western University in 1989- His diesel fuel tax surcharge of six cents California, Berkeley, where she reports, but they mean very little research focuses on the effects of per gallon that generates some $70 received her doctorate in architectural monetary policy and the banking because they are unanalyzed, in effect million annually. According to Haack, 'paper audits,'" says Dickinson. "In history in the fall of 1989 and her system on the business cycle. the Pennsylvania General Assembly master's degree in architecture in most cases the Federal Highway Christopher G. Lamoureux, has authorized the treatment of 6,500 1982. A native of Thessalonike, Administration is not able to observe Ph.D., associate professor of finance, out of 8,000 deficient bridges in Greece, Bastea earned her bachelor's state inspectors in action. We also comes to Washington from Louisiana Pennsylvania. The department's goal in art history from Bryn Mawr College State University, where he had been have proof of inspection forms that is to repair or replace 200 bridges per were filled out but the inspections in 1980. Her field of specialization is an assistant professor of finance since year. Since 1983, he says, the program Byzantine art and architecture in the were not made. This certainly isn't the 1985. He received a bachelor's degree has been responsible for repair or Balkan countries, and her current norm, but it happens. While the in business administration from the replacement of 1,100 bridges. research interests include American situation isn't alarming, if something is University of South Florida in 1978. At urbanism and architecture using St. not done about it, some tragedies are What should be done Syracuse University, he earned a bound to happen." To fund needed repairs to the Louis as the example, and German master's in business administration architectural theory and education The reasons behind the decline nation's bridges, Haefner offers (1983), a master's in economic theory during the 19th century. in the nation's bridges are diverse and several suggestions: more toll roads, (1984), and a doctorate in finance complex, although bureaucratic and modifications in truck-weight users' Eric C. Beyer, M.D., Ph.D., (1985). His research focuses on the assistant professor of pediatrics, financial issues are at the root of the fees, special district funding that could functioning of financial markets. medicine and cell biology, joins the problem, says Haefner, who is the be funneled into a maintenance Charles Oriel, Ph.D., assistant University from Harvard Medical author of more than 100 technical account and the notion of leasing professor of Spanish, joins School, where he was an assistant papers and Introduction to Transpor- bridges — an investment incentive for Washington's faculty from George tation Systems, a popular civil engi- private industry to build bridges that professor of pediatrics. He earned a Washington University, where he was neering textbook. the government would lease. bachelor's in biological sciences from a lecturer in the Spanish department. the University of Chicago in 1976. He "Fluctuations in the economy "Like barges or aircraft, which He earned his bachelor's degree in received a doctorate in physiology have played a key role," he says. "For the private sector leases to govern- literature from American University in instance, when the oil crunch of the ment, leased bridges might bring and pharmacology in 1981, and his 1977, and his master's in Spanish early 70s hit, the price of oil went up, higher quality construction and medical degree in 1982, both from the literature in 1983 and doctorate in driving down consumption of gaso- maintenance to the fore, if companies University of California, San Diego. romance languages and literatures in line and oil. The Federal Highway can be lured with tax incentives or His research interests include cell May 1989, both from George Wash- Trust Fund, the source of dollars for other means," says Haefner. "The membrane and cell surface molecules ington University. His research and structural specializations involved transportation building and mainte- point is, we need creative financing interests include Spanish poetry and nance, is driven by taxes derived from because the old way has shown itself in cellular communication, adhesion drama of the Golden Age, focusing on and development. gas and oil taxes. The result was an to be inefficient." Garcilaso de la Vega, Francisco de James M. Cheverud, Ph.D., obvious underfunding of the Federal He suggests also a domestic Medrano and Miguel Cervantes. associate professor of anatomy at the Highway Trust Fund during this equivalent to the World Bank, "a do- period, and subsequently less atten- mestic development bank that would medical school, was an associate professor in the departments of tion paid to the repair of bridges and treat the squeakiest wheels first." anthropology and cell biology and highways." Finally, Haefner warns that the anatomy at Northwestern University Ironically, the Highway Trust nation's infrastructure — including its RECORD Fund has a cash balance of more than clattering bridges — is in peril be- before joining Washington's Depart- ment of Anatomy and Neurobiology. $14.5 billion in unspent funds, cause the curricula at our engineering according to an Aug. 30 article in the schools do not adequately address the He received a bachelor's degree in Editor: Susan Killenberg, 889-5254, anthropology from Northwestern in Wall Street Journal. The funds remain topics of infrastructure, financing, Campus Box 1070; P72245SS at WUVMC 1975, and both a master's and doctor- Editor, Medical Record: Joni Westerhouse, sequestered in a government bank management and maintenance. ate in anthropology from the Univer- 362-8257, Medical School Campus Box 8065; account, the article states, to make the "Maintenance is a vital compo- C72245JW at WUVMD budget deficit appear smaller. nent to keep the infrastructure in a sity of Wisconsin, Madison, in 1977 Contributing writers: Debby Aronson, Debra Bernardo, Joyce Bono, Tony DiMartino, Gerry "In the '80s and now looking into state-of-the-art condition," Haefner and 1979, respectively. His research interests include quantitative, human Everding, Tony Fitzpatrick, Fran Hooker, Steve the '90s, the nation's infrastructure is states. "But the newest tools in Kohler and Carolyn Sanford still trying to compete because of engineering, such as computer-aided and population genetics, evolutionary Photographers: Joe Angeles, Tom Heine, theory, and human and non-human David Kilper and Herb Weitman funding problems created by this tax- design and computer-aided mechan- primate biology. Record (USPS 600-430; ISSN 1043-0520), driven system," says Haefner. ics, are not geared toward mainte- Volume 14, Number 14/Dec. 7, 1989. Published Haefner cites Pennsylvania, a nance, but rather design. Moreover, Cynthia A. Loveland Cook, weekly during the school year, except school Ph.D., assistant professor of social holidays, monthly during June, July and August, state with 54,000 bridges, many of these tools are popular in the private work, comes to the University from by News and Information, Washington which span several major waterways, sector, but not in the government. As University, Box 1070, One Brookings Drive, as a state with some progressive ideas a result, often the lesser talented are the Great Lakes Regional Health St. Louis Mo. 63130. Second-class postage paid Services Research and Development at St. Louis, Mo. of how to attack the problem. in charge of maintenance." Address changes and corrections: The state's Billion Dollar Bridge Procrastination will cost the Field Program of the Veterans Admini- stration in Ann Arbor, Mich., where Postmaster and non-employees: Send program, begun in 1982, is a "popu- country dearly as it moves toward the address changes to: Record, Washington lar, goal-oriented approach that is next century, Haefner warns. "Our she was principal investigator of University, Box 1070, One Brookings Drive, making headway into the problem of infrastructure is suffering from too research in mental health, health and St. Louis, Mo. 63130. Hilltop Campus employees: Send to: Person- bridge maintenance," says Harvey many stop-gap measures and incon- social work. She earned a bachelor's in nursing from the University of nel Office, Washington University, Box 1184, Haack, deputy secretary for planning sistent policies," he says. "If we don't One Brookings Drive, St. Louis, Mo. 63130. for the Pennsylvania Department of rebuild it now, we'll have a severely Arizona in 1968, a master's in social Medical Campus employees: Send to: Payroll work from the University of Washing- Office, Washington University, Box 8017, Transportation. "Our primary objective handicapped economy and a threat- 660 S. Euclid, St. Louis, Mo. 63110. is to repair or replace all the closed or ened population in the 21st century." ton, Seattle, in 1974 and a doctorate in Tony Fitzpatrick NOTABLES

Neil N. Bernstein, LL.B., professor of inducted into the Louisiana State law, spoke at the "Personnel Law University Alumni Hall of Distinction. Auditorium named for May Co. Update 1989" conference, sponsored The induction ceremonies were held by the Council on Education in in Baton Rouge. O'Neal received both The John M. Olin School of Business support will help us toward our Management. The topic of his lecture his bachelor's degree (1938) and his has recognized the strong support of objective of becoming a leading was the right of employers to institute juris doctorate (1940) from Louisiana the May Department Stores Co. by business school." substance abuse programs for their State. naming its main lecture hall for the St. The May Co. commitment workers. Louis-based retailer. includes $200,000 for general operat- Helen W. Power, Ph.D., adjunct The May Department Stores Co., ing funds and $1 million in business John R. Bowen, Ph.D., assistant assistant professor of women's studies, which recently committed $1.2 million school endowment funds. The professor of anthropology, delivered a presented a paper, titled "Part-Time to Washington University, was hon- endowment gift will be matching paper at the University of Kent, Faculty in Women Studies," at the ored Nov. 21 during a dedication dollar-for-dollar from a $15 million Canterbury, on healing and sorcery in Midwest Women's Studies Association ceremony held at a meeting of the challenge grant from the New York- Indonesia, where Bowen had spent Conference, held in October at the Century Club, a business school based John M. Olin Foundation. the summer doing fieldwork. Articles University of Nebraska-Lincoln. alumni group. David C. Farrell, chairman and by Bowen appear in the October "We are very proud to have the chief executive officer at May Co., issue of Comparative Studies in Carter Revard, Ph.D., professor of May Company name associated with said at the ceremony that the donation Society and History and in the De- English, who spent the summer in the Olin School of Business in this was the company's way of showing cember issue of Man. England on an NEH travel grant, way," said Dean Robert L. Virgil, support for a school "that is a very presented a paper at the York Univer- D.B.A. "May Company is one of the positive force in the St. Louis commu- Judy Fox, head of cataloging and sity manuscript conference. At the world's leading retailers and its nity and the country generally." classification services, and Kay biennial conference, which focuses on Kanafani, senior systems librarian, Medieval manuscripts, Revard pre- co-wrote an article published in the sented his work on Harley 2253. Professor Steven Schwarzschild dies at 65 September 1989 issue of Information Harley 2253 is a British library manu- Steven S. Schwarzschild, D.H.L., congregation in Fargo, N.D., and a Technology and Libraries. Titled script anthology on the best Middle- professor of philosophy and Judaic Conservative Jewish congregation in "Global Change Capabilities to English lyrics, including Latin, French studies, died suddenly on Friday, Dec. Lynn, Mass., between 1950 and 1964. Improve Authority Control in an and English political, humorous, 2, at Jewish Hospital in St. Louis after A lifelong democratic socialist and Online Catalog," the article describes devotional and raunchy poetry and suffering an aneurysm. He was 65. pacifist, Schwarzschild declined the implementation of an online prose. He was quoted in a Times The funeral was held Dec. 5 at service in the military chaplaincy authority control process in the Olin Higher Education Supplement. His Riverside Memorial Chapels in New upon ordination and instead served as Library System, which library staff presentation will be published in early York, with interment following at the the rabbi of the Jewish communities developed using modifications from 1991 in proceedings from the confer- Congregation Habonim section of in both parts of Berlin and in East existing software. ence Cedar Oak Cemetery, Paramus, NJ. A Germany from 1948 to 1950. memorial service is pending for next He was editor of Judaism, a Beverly Kobeissi, business manager Charles J. Sutherland, M.D., assis- month at Washington University. leading scholarly journal, from the for radiation oncology in the Depart- tant professor of orthopedic surgery, Schwarzschild was an internation- mid-50s to the mid-60s, and published ment of Radiology, was awarded the delivered a paper on "3-Dimensional ally known authority on Jewish numerous articles on philosophy, Distinguished Service Award by the Imaging in Surgical Planning" at the philosophy, theology and politics. He is the author Society of Radiation Oncology Admin- second international symposium on especially on of two books to be published by the istrators (SROA). She was the first custom-made prostheses, held in Maimonides and State University of New York Press in recipient of the society's highest Chicago. The paper presented strate- Hermann Cohen, early 1990. honor, which recognizes outstanding gies for applying 3-dimensional as well as on Born in Frankfurt, Germany, his contributions to the society and the medical imaging data to computer Immanuel Kant. family had been residents of~that city'* profession. SROA was established in assisted engineering and solid mod- He had taught ghetto dating to the early 15th cen- 1983. Kobeissi, who received the elling systems. Co-authors of the religious philoso- tury. He escaped Hitler Germany with award in October at the sixth annual paper include Michael W. Vannier, phy at Washing- his family in 1939, and attended high SROA meeting, held in San Francisco, M.D., professor of radiology, and ton University school in New York and the Univer- has served the society in numerous Steven J. Bresina, research associate since 1965. Prior, sity of Cincinnati. elected and appointed capacities, in orthopedic surgery and a doctoral Steven S. Schwarzschild he was a visiting He is survived by his wife, Lily including as national president and candidate in civil engineering. professor at Brown University and Rose Schwarzschild, a native of board chairman. The meeting was held visiting chairs at the Hebrew Uni- London; their son, Maimon, a profes- held in conjunction with the Society Murray L. Weidenbaum, Ph.D., versity in Jerusalem and at Notre sor of law at the University of San of Therapeutic Radiation Oncologists. Edward Mallinckrodt Distinguished Dame University in Indiana. Diego, now visiting at New York Law University Professor of economics and Ordained a rabbi at the Hebrew School; and a brother, Henry, an James McGarrell, professor of art, director of the Center for the Study of Union College in Cincinnati, Ohio, in official of the American Civil Liberties displayed a 16-year survey of litho- American Business, recently delivered 1948, he had served a Reform Jewish Union in New York. graphs, and one etching, titled "A two lectures to the Wharton School of Print Survey: 1975-1989," during an the University of Pennsylvania. The exhibit at Printworks Gallery in lectures were on "Corporate Take- Chicago, 111. McGarrell's exhibit, which overs: Winners and Losers" and "The was reviewed in the Chicago Tribune, Global Marketplace and Government NEWSMAKERS included an image from the 1978 Policy." Weidenbaum also presented a "Stanza" portfolio that the art critic lecture on "The Competitive Status of Washington University faculty and staff economics, regarding the serious Alan G. Artner referred to as "beauti- U.S. Manufacturing" at the annual make news around the globe. Follow- housing shortage in the 1950s. ful" in his review. The image "evokes meeting of the National Association of ing is a digest of media coverage they A human breast implant made of Pierre Bonnard's bathtub luminous Business Economists in San Francisco. have received during recent weeks for peanut oil, which will not interfere paintings," wrote Artner. their scholarly activities, research and with cancer detecting X-rays, has been Colette H. Winn, Ph.D., associate general expertise. discovered by Judy Destouet, M.D., James Nicholson, lecturer in the professor of French, delivered a paper "The Changing Face of a Restless associate professor of radiology, and Performing Arts Department, spent the at the Colloque International "Joachim Nation," a Sept. 25 Business Week V. Leroy Young, M.D., associate summer in residence at the Tyrone du Bellay" in Angers, France. The article about population shifts that are professor of surgery. An article about Guthrie Centre, Annaghmakerrig, Eire, paper is titled "Ecriture et Negation still remolding America, quotes their discovery appeared in the Sept. at the invitation of the Arts Councils dans les Regrets de Joachim du Charles L. Leven, Ph.D., professor of 25 issue of Newsweek. of Ireland as part of a cultural ex- Bellay". change in conjunction with New Dramatists in New York. Daryl Youngman, science/engineer- ing librarian and director of the Center AIDS virus continued from p. 1 F. Hodge O'Neal, S.J.D., dean emeri- for the Study of Data Processing against HIV, a different one was more School of Medicine, and Steve Adams, tus and George Alexander Madill library, has published a report, tided successful against the Moloney virus. Ph.D., at Monsanto Co. Professor Emeritus of Law, was "Tools for Decision Support: An The analogs are produced by substi- This research has been supported Overview of Online Database Search- tuting sulfur and oxygen for native by The National Institutes of Health ing and Optical Disc Technologies," atoms at various locations in the and by Monsanto through the Wash- Red Cross relief for the center's Working Paper Series. myristic acid molecule. ington University/Monsanto Joint Within a week of the Oct. 17 San "At the very least," Gordon says, Research Agreement. Signed eight Francisco earthquake, students, faculty "these analogs will be useful tools to years ago, and now having a total Have you done something help us understand the role of fatty value of more than $62 million, the and staff of Washington University's noteworthy? Program in Physical Therapy and acids in viral replication. They might joint research agreement is the largest biological research-support program Irene Walter Johnson Rehabilitation Have you: Presented a paper? Won an award? also prove to have significant clinical Institute raised more than $400 for the Been named to a committee or elected an officer potential." between an American corporation and American Red Cross earthquake of a professional organization? The idea for these compounds a university. The Washington University Record will help "Monsanto played a key role in the disaster relief program. spread the good news. Contributions regarding came from an analysis of how N- "We had heard that the Red Cross' faculty and staff scholarly or professional myristoyltransferase works, and development of this project because of resources were exhausted from activities are gladly accepted and encouraged. specifically from the observations of a their interest in a fundamental biolog- Send a brief note with your full name, highest- M.D./Ph.D. graduate student in ical question — the role of fatty acids Hurricane Hugo and we were just earned degree, current title and department responding to a call for funds," says along with a description of your noteworthy Gordon's lab, Robert O. Heukeroth. in protein function," Gordon said. Jack Hurov, a first-year student in the activity to Notables, Campus Box 1070, or by Testing of the compounds was done "Their support occurred well before electronic mail to p72245SS at WUVMC. Please together with Lee Ratner, M.D., Ph.D, we could have predicted that these physical therapy program, who include a phone number. helped organize the fund-raiser. and Marty Bryant, M.D., Ph.D., at the new compounds would be discovered." MEDICAL RECORD Alcoholic males may affect intelligence of offspring Alcoholic mothers who often sacrifice their unborn children's health to fetal alcohol syndrome may not be the only ones taking that horrific risk with the future. Groundbreaking investiga- tions at the School of Medicine suggest that fathers who drink heavily prior to the conception of their children also might be instrumental in producing long-term toxic effects in their offspring. The research shows that adult male rats sired by "alcoholic" fathers required significantly longer than their normal counterparts to acquire two learning tasks regularly used to test memory in laboratory rats. "They showed a basic flaw in their ability to learn," says Theodore J. Cicero, Ph.D., who directed the study. On develop- mental measurements and in all other observations, the "paternal alcohol" offspring — never exposed to alcohol themselves — were normal. "A lot of time and energy have been spent investigating the damage an alcoholic mother does to her offspring. Now we must begin to consider the father's role," says Cicero, a professor of neuropharma- cology. Though he and his co- investigators are not comfortable extrapolating directly from their laboratory work to the human popula- tion, Cicero says the results of the animal study should, "sharply refocus clinical investigations into the effects Theodore J. Cicero, Ph.D., and co-investigators spent two years double-checking results before presenting their findings at the 19th Annual Meeting of the of alcohol." Society for Neuroscience in late October. The research, part of a series of bred to normal females that had eaten older age, but no deficits were found. of these questions will require the experiments done over the last seven only alcohol-free food, the male rats When the male rats were careful design of more studies. years exploring the effects on off- got no alcohol for two weeks to reevaluated much later (seven to eight Working in the laboratory of spring of alcoholic .sires, used male eliminate any withdrawal symptoms months of age) on another test of re- John W. Olney, M.D., professor of rats given free access to a diet in that might confound results. Fifteen cent memory conducted in a T-maze, psychiatry and neuropathology, which 35 percent of the calories were rats were on the protocol, along with learning ability was still significandy Wozniak also plans to look for derived from alcohol. Cicero says 15 control animals eating non- impaired in the test animals. The def- abnormalities in the brains of the such a diet makes them, "heavily alcoholic rations. icit displayed by the male offspring of paternal alcohol offspring. Potentially dependent and intoxicated much of David F. Wozniak, Ph.D., a the alcoholic sires does not go away important to understanding the the time, the equivalent of human al- research instructor of psychology in as they age. It is not "developmentally mechanism of the deficit, such coholics." Tests of blood alcohol psychiatry and the co-investigator overcome," in Cicero's words. abnormalities are likely to be, "very content in the animals revealed levels who conducted the behavioral The learning impairment also subde and difficult to localize," of 100 milligrams per 100 milliliters, studies, says other controls were appears to be relatively selective. Woznaik says. an amount commonly expressed as .1 employed as well. For example, Wozniak reports that the lab animals Cicero says his lab will use the percent. Wozniak says, the experimental are now being tested on tasks not model developed here to explore animals in the study were yoked with related to spatial or working memory, suspicions that the offspring of control rats on the basis of litter size, and early results show no difference alcoholic sires also suffer from and body weights at birth were not between the groups. impaired immune systems and "A lot of time and different between the two groups. Alcoholism has been well abnormal hormonal patterns as energy have been Rat pups sired by both the alco- established as a disease with a genetic suggested by clinical observations and holic males and normal males were component, but researchers have other animal research. spent investigating the compared for body weight at several looked principally for a personality To effectively measure the damage an alcoholic stages in their growth and the times at trait or a behavioral predilection implications of the current study for which developmental landmarks, such passed along as the triggering factor, human beings, clinical investigators mother does to her as eye opening, appeared. In all Cicero says. This new work suggests will have to do some rethinking, offspring. Now we cases, no significant differences were that the effect, while still genetically according to Jack Mendelson, M.D., must begin to consider found. Wozniak also compared the transmitted, may be more biochemi- professor of psychiatry and neuros- pups on two sensorimotor tests. One cally direct and not a function of cience at Harvard Medical School. the father's role." test measured time spent on a steeply generations-old genetic trait. "The studies and the controls will be — Theodore J. Cicero inclined screen; the other assessed The mechanism by which the more difficult to design for humans" their ability to turn 180 degrees on a specific deficit occurs is not yet clear, Mendelson says, "but that is always gently inclined slope. Again, no but the possibility exists that alcohol the case. Most of what we know differences were found between the has a toxic effect on sperm, perhaps about many diseases — cancer and Because rats do not naturally like test subjects and the controls. doing direct chromosomal damage. heart disease are examples — we the taste of alcohol and eat less than But after the offspring reached Rat sperm have a life of 42 days, long learned using animal studies as normal when it is disguised in their maturity (75 days), the investigators enough that the sperm responsible for guides. I look forward to applying food, control animals were pair-fed — trained them on a spatial learning task conception were viable during the Cicero's principles in my own work." given exacdy the same number of and found a reliable performance period of the rat's "alcoholism." The He adds, "this is an extremely impor- alcohol-free calories and the same deficit among the male offspring of effect might translate into a learning tant development and spectacular nutrients. alcoholic sires. The animals were tes- deficit for animals conceived via the science. That some changes affecting The chance to separate the ted in a radial arm maze — a device damaged sperm. That, however, has cognitive development are transmit- effects of alcohol from the effects of in which a rat is thought to use var- yet to be shown, and Cicero says table through the male will stimulate the poor nutrition so often suffered by ious objects it sees in the test room as precisely defining the mechanism is huge interest." alcoholics is just one of the advan- cues to recall which arm of the maze one of the big tasks this research sets Cicero and his co-investigators, tages available to the scientist who it has already traveled. In order to get for investigators. aware of the impact their work may controls his experimental procedure a reward, the rat must learn to visit In addition, Cicero and Wozniak have, spent two years double-check- in animals, Cicero points out. For the only previously unused arms of the are following other avenues of ing results before presenting their data clinical investigator, the study of maze. And the paternal alcohol rats investigation. They are replicating the at the 19th Annual Meeting of the alcohol's effects is complicated by took significantly longer to learn that. entire study now to further substanti- Society for Neuroscience in late issues of personality, genetics and In fact, Wozniak reports, normal rats ate their results. And they would like October. Their evidence that alcohol environment that the laboratory mastered the task in an average of just to know how much alcohol is re- consumption in rodent fathers pro- scientist controls. over eight days; the offspring of alco- quired to produce the effect. How duces a toxic effect in offspring is For 39 days, the male rats ate a holic fathers required 12 days, nearly long must a male rat go between liable to focus the light of science on diet in which the alcohol content was half again as long. Once the animals ingesting alcohol and conception how male parents risk their children's gradually increased to allow adapta- had learned the task, both groups before the effect of the alcohol development — one more way in tion, stabilized, then reduced to retained their lessons equally well. disappears? Is the risk diminished by which alcohol acts as a poison. prevent withdrawal. Before being Female rats were also tested at an long-term abstinence? Answering each Steve Kobler Dacey is new head of neurosurgery Ralph G. Dacey Jr., M.D., has been named professor and head of Neuro- logical Surgery and co-head of the Department of Neurology and Neuro- logical Surgery at the School of Medicine. Dacey's appointment, effective Nov. 20, was announced by Chancel- lor William H. Danforth. Dacey will replace Sidney Goldring, M.D., who has headed the department since 1974. Goldring, who specializes in the surgical treatment of epilepsy, is retiring from administrative duties and will concentrate fulltime on patient care and research activities. "We are very pleased that Ralph Dacey will head the Department of Neurological Surgery," says Danforth. "His clinical and research experience is impressive, and his leadership should ensure that the department will continue to be a national and international leader." Dacey comes to the University from the University of North Carolina at Chapel Hill, where he has been professor and chief of the division of neurological surgery. In addition to Joel Perlmutter, M.D., and Lee Tempel, M.D., examine Parkinson's patient Morman Becherer. his School of Medicine post, Dacey will serve as neurosurgeon-in-chief at Barnes Hospital, and on the staffs at Major advance in Parkinson's disease treatment Children's and Jewish hospitals at People diagnosed with early Greater St. Louis Chapter of the Amer- patients remained gainfully employed, Washington University Medical Parkinson's disease may now be able ican Parkinson's Disease Association. which can mean increased productiv- Center. to substantially delay the onset of Twenty patients from the St. ity and annual savings of hundreds of Dacey's major clinical interest is disabling symptoms by taking the Louis area were among the 800 millions of dollars. Side effects in the treatment of cerebral aneu- drug deprenyl. nationwide who took part in the associated with deprenyl were minor. rysms, arteriov- This finding, reported November study, which began in 1987. Results The DATATOP study is ongoing, enous malforma- 16 in the New England Journal of indicated that the drug deprenyl sig- but because of the dramatic nature of tions and basal Medicine, is a result of the largest nificantly delayed the time until these the findings, has been modified so '■ ■■■. skull tumors. His controlled clinical trial ever conducted patients, who all had early Parkinson's that all participating subjects now take research focuses for Parkinson's disease, according to disease, required levodopa therapy to deprenyl. on cerebral arte- Joel S. Perlmutter, M.D., assistant treat serious disabilities. Levodopa, The study investigators hope that rioles, minute professor of neurology at the School the mainstay of treatment for the continued monitoring of subjects blood vessels in of Medicine. Perlmutter headed the St. Parkinson's disease, suppresses many to the planned conclusion of the trial the brain, and Louis portion of the multicenter trial. symptoms but does not slow the in 1992 will provide more information their responses to "Though not a cure, the study progression of the disease; its benefit about the long-term effects of various types of Ralph G. Dacey Jr. shows deprenyl dramatically delays to patients is limited because it works deprenyl, the potential benefits of injury or disease. the onset of disabling symptoms, only temporarily. tocopherol and the interaction of Currently, he is investigating cellular which means for patients a longer "This finding that deprenyl delays these experimental treatments. changes that occur in these blood period of time to continue working, the need for levodopa is particularly Investigators will examine the effects vessels with age and hypertension. participate fully in family activities, important for Parkinson's patients at of deprenyl before and after the need His work is funded through a five- and enjoy physical well-being," says the early stages of the disease," for levodopa, and begin to assess the year grant of more than $400,000 from Perlmutter. Perlmutter explains. In addition to its impact of treatments on factors such the National Heart, Lung and Blood Deprenyl and a special form of limited effectiveness, he notes, as chemical measures in cerebrospinal Institue of the National Institutes of vitamin E called tocopherol were sys- levodopa and similar medications can fluid, mental functioning and life Health. tematically evaluated in the DATATOP be associated with adverse effects expectancy. All DATATOP findings He also has studied the re- (Deprenyl and Tocopherol Antioxida- including abnormal involuntary are coordinated through the Univer- sponses of intracerebral arterioles to tive Therapy of Parkinsonism) study. movements, clinical fluctuations, and sity of Rochester in New York. acetylcholine and other neurotransmit- The School of Medicine is one of 28 hallucinations. "We hope the ongoing study will ters. He has conducted extensive study sites in the United States and Research subjects who received provide additional information on research on the reactions of arterioles Canada participating in the clinical deprenyl reached a predetermined how to better treat the disease and to vascular injury, looking particularly trial, conducted by the Parkinson point of disability nearly one year ultimately to help find a cure," says at how the inner linings of cerebral Study Group and sponsored primarily later than those who did not receive Perlmutter. "But for now, we're happy blood vessel walls change and interact by the National Institute of Neurologi- deprenyl (26 months to disability with that we can extend the quality of life with the deeper vascular smooth cal Disorders and Stroke of the deprenyl vs. 15 months without for people at the early stages of this muscle when injury occurs. The work National Institutes of Health. Addi- deprenyl). Deprenyl treatment also debilitating disease." is especially relevant to vasospasm, or tional local support is provided by the significantly increased the time constriction of blood vessels, which is the primary cause of morbidity and mortality in stroke due to rupture of $3.5 million intracranial aneurysms. Dacey received the doctor of Grant funds local effort to prevent AIDS among IV drug users medicine degree in 1974 from the University of Virginia. He completed a The National Institute on Drug Abuse to distribute vouchers for drug been impossible, largely due to lack residency in medicine at Strong has awarded $3.5 million to the treatment. of funds. Over time, the investigators Memorial Hospital in Rochester, N.Y., School of Medicine for research "At last we, as researchers, have will evaluate street outreach and and a residency in neurosurgery at the designed to improve drug treatment in the opportunity to work directly with improvements in the treatment University of Virginia. His training also order to prevent the spread of HIV St. Louis area treatment programs to programs and compare their effective- included a year as a postdoctoral infection among IV drug users in the help the intravenous drug user," says ness. The team will administer stan- fellow in physiology at the University St. Louis area. epidemiologist Linda B. Cottier, Ph.D., dardized interviews to examine a of Virginia as an American College of The four-and-a-half year grant principal investigator of the study. number of factors, including relapse Surgeons Schering Scholar. He was a will support researchers from the "Minority drug users need particular to drug use, needle sharing and high faculty member at the University of Department of Psychiatry in an effort attention because they often are less risk sexual behaviors, the programs' Washington and the University of that is unprecedented locally: to likely to enter treatment." Cottier, a retention rates, employment, psychiat- Virginia before joining the University persuade rv drug users to get treat- research instructor in psychiatry, will ric symptoms and rates of HIV of North Carolina faculty. ment by providing 300 new treatment head the collaborative effort involving infection. He is a diplomate of the Ameri- slots at a drug-free program and a Washington University faculty in Cottier currently is conducting can Board of Neurological Surgery methadone maintenance clinic. This psychiatry and pediatrics, two area the first study in the St. Louis area on and the American Board of Internal will significantly reduce waiting lists substance abuse treatment programs the prevalence of HIV infection in IV Medicine, a fellow of the American for drug treatment in the inner city. In — BASIC and West End Clinic — and drug users and their needle-sharing College of Surgeons and the Stroke addition, the project will provide the Metropolitan AIDS Program. and sexual partners. That three-year council of the American Heart Asso- street out reach in high risk areas to Researchers will work with the project is also funded by the National ciation, and a member of numerous educate the community on ways to staff at these centers to make program Institute on Drug Abuse. other professional organizations. reduce the risk for Hrv infection and improvements that until now have MEDICAL RECORD

Med school named institute of quality by Prudential The School of Medicine has been named one of only seven centers nationwide in which patients can receive allogeneic bone marrow transplants under the Prudential Insurance Company's Institutes of Quality (IQ) program. RQGRAH IN Prudential is the world's largest commercial provider of health care xoixnaML mm coverage. Its IQ program is designed to guide patients to institutions with superior track records in performing ifH pmmgJIT high-tech medical treatments and high standards in all aspects of medical care. Barnes Hospital, a sponsoring institution of the Washington Univer- sity Medical Center, was selected because of its experience and success ~^i~^r~88S§? rate in performing allogeneic bone marrow transplants, which use bone marrow provided by a donor. Accord- ing to medical services experts, there will be 12,000 candidates for allo- geneic bone marrow transplants in the United States this year. Wheel power: John Enright, who is trekking by wheelchair across America and back again, made the School ot Medicine one ot his stops wnile in The six other centers participat- St. Louis recently. He gave a talk to faculty, students and staff of the medical school's Irene Walter Johnson Institute of Rehabilitation and occupational and ing in the IQ network are The City of physical therapy departments. The purpose of the journey, Enright says, is to inspire people with physical disabilities and to raise awareness about the need Hope National Medical Center in for better, more accessible facilities to accommodate the disabled. Enright, who lost use of his legs seven years ago, completed a one-way trip across America in 1983- In January when he completes this journey, begun in December 1988, he will be the first to have traveled by wheelchair across the United States Duarte, Calif.; The Fred Hutchinson and back again. He is accompanied by his wife, Vicki, who drives behind in a van, and a friend, Ron Ballichi, who also is confined to a wheelchair. Cancer Research Center in Seattle, Wash.; The University of Minnesota Hospital and Clinic, Minneapolis; The Medical Center at the University of First effective treatment found for hepatitis C California, San Francisco (pediatric only); The Johns Hopkins Health Researchers at the School of Medicine liver damage promptly fell to normal frequency and durability of response," System, Baltimore, Md.; and Shands are part of a team that has found an in 38 percent of patients" who received notes Perrillo. Such a study is cur- Hospital at The University of Florida, effective treatment for reducing the three million units, in 16 percent of rently underway at the School of Gainesville. liver damage caused by chronic those who received one million units, Medicine, in conjunction with the VA Under the IQ program, a physi- hepatitis C, a sometimes fatal disease. and in 4 percent of untreated patients. Medical Center. cian is asked to refer patients needing Results of a multicenter study Furthermore, patients taking the larger Hepatitis C is one of several one of the designated treatments or published in the Nov. 30 issue of The dose showed a significant reduction in different types of hepatitis caused by surgical procedures to the nearest New England Journal of Medicine liver damage, as measured by liver viruses that attack the liver. The participating facility. In addition to the indicate that a six-month course of biopsy. hepatitis C virus, discovered earlier benefits normally paid, the patient's Intron A, recombinant human alpha Of those patients who improved, this year, is spread mainly by expo- travel costs to and from the facility are interferon, resulted in significant one-half showed improvement lasting sure to blood and blood products, reimbursed. Travel and accomodation improvement in liver function tests in longer than six months after treatment and is often found in hemophiliacs, expenses for a family member or about half of patients with hepatitis C. ended. In addition, many patients dialysis patients and health care other close companion accompanying Hepatitis C accounts for more than 90 experienced a lessening of the workers. the patient are eligible, too. The percent of all hepatitis cases con- debilitating fatigue and malaise that The Centers for Disease Control donor's expenses are also covered for tracted through blood transfusions — characterizes chronic hepatitis C. estimates that between 1 and 3 allogenic bone marrow transplants. approximately 150,000 cases per year According to the study, side percent of all Americans carry the In addition to allogenic bone in the United States. Half of those effects associated with interferon hepatitis C virus. Although many cases marrow transplants, other procedures cases will develop chronic hepatitis C, therapy were tolerable and usually of the chronic form are asymptomatic performed in Prudential's IQ program which can lead to cirrhosis of the liver short-lived. These side-effects, which and mild, cirrhosis, a destructive and include heart, liver and kidney and liver failure. included flu-like symptoms such as sometimes fatal liver disease, develops transplants, as well as kidney stone "Until now, no therapy has been muscle ache, headache and fever, in at least 20 percent of patients with treatment. The program is available in shown effective in treating chronic typically improved or ceased as chronic hepatitis C. most states to individuals enrolled in hepatitis C," says Robert P. Perrillo, therapy continued. Other major types of viral hepa- Prudential group health plans. M.D., associate professor of medicine "We are extremely encouraged titis include hepatitis A, transmitted by at the School of Medicine and director by the results of this study, but future exposure to contaminated food and of the division of gastroenterology at studies are needed to determine water, and hepatitis B, transmitted by Gait/balance study the Veterans Administration Medical whether a different dose or longer exposure to infected blood or blood Center. Perrillo directed the local trial duration of treatment will increase the products or close, personal contact. adds component; of Intron A. "Recombinant alpha interferon — a genetically engineered volunteers needed protein that has antiviral and immuno- OASIS grant aim: to help older adults genic properties — finally offers the Researchers at the School of Medicine potential for arresting the progression meet emotional challenges of aging and Jewish Hospital are seeking of hepatitis C and relieving its symp- volunteers with mobility problems to A $90,000 grant to evaluate the effects throughout the OASIS network. Plans toms." Intron A is produced by participate in a gait and balance study. of a program to help older adults are to evaluate four curriculum Schering Corporation. The study, which began two meet the mental and emotional modules dealing with self-esteem, Washington University was one months ago, has been expanded and challenges of aging has been awarded activity and leisure, relationships and of 12 centers participating in the 166- will evaluate not only gait and bal- to OASIS (Older Adult Service and empowerment for older adults, and to patient study, the first large, controlled ance, but also whether exercise will Information System). conduct pilot tests in St. Louis OASIS trial to assess the effectiveness of help people with mobility problems. OASIS is the St. Louis-based centers beginning this spring. After alpha interferon therapy in treating To be eligible, participants must be 65 national educational, cultural and the modules have been thoroughly hepatitis C. The principal investigator years of age or older and have wellness program for people 60 and tested and revised over the two-year was Gary L. Davis, M.D., at the mobility problems such as falling, or older. The group's two-year grant, grant period, they will be ready for University of Florida in Gainesville. difficulty climbing stairs or walking 10 funded by the Retirement Research use in other OASIS cities. All participants in the study had blocks. They also must not be in- Foundation of Chicago, is titled OASIS was founded in St. Louis contracted hepatitis C by blood volved in a regular exercise or "Positive Attitudes, Positive Aging." in 1982 to provide educational, transfusion or occupational exposure physical therapy program more than The project will be conducted in cultural and health maintenance to blood. One-third of the group once a week. conjunction with the School of programs for those over the age of 60. received three million units of alpha Volunteers will receive a free Medicine's Program in Occupational Initially funded by a grant from the interferon given three times weekly evaluation of balance and gait by a Therapy and the Jewish Hospital Department of Health and Human for six months, one third received one geriatric physician and physical Program on Aging. Both the School of Services, Administration on Aging, million units on the same schedule, therapist, as well as recommendations Medicine and Jewish Hospital are OASIS now receives major support and the remaining third did not on how to minimize physical disabil- local sponsors of OASIS along with from the May Department Stores Co. receive any treatment. ity. For those participants who qualify, Famous-Barr. Currently there are 22 OASIS centers Compared with the untreated an exercise program, conducted by a The grant will enable OASIS to in May Company stores in 17 cities. group, those who received three physical therapist at the School of evaluate a program that could make a The St. Louis OASIS centers are million units of interferon showed a Medicine, will be offered. significant difference in the quality of located at Famous-Barr Clayton, significant reduction in liver damage. For information, call 454-8150. life for older adults in St. Louis and Northland and Southtown stores. Levels of an enzyme that indicates PERSONNEL NEWS Searches for professional positions are under way Washington University is conducting human resources, research administra- searches to fill a professional position tion and other responsibilities outside on the Hilltop Campus and three of finance and physical plant services. professional positions on the Medical The assistant dean for Administra- Campus. tion will be responsible for develop- ing appropriate administrative and Hilltop opening organizational support structures for Associate Director of International the School of Medicine in these areas, Studies — Washington University developing and implementing related announces the opening of a new policy and procedures and supervis- position as associate director of ing all related personnel. International Studies. Under the Director of Facilities Management guidance of the director of Interna- — Requirements: a BS/BA in business, tional Studies, the associate director engineering, health administration or will have a full-time administrative related management field, with a role involving coordination of interna- minimum 5 years of senior facilities tional and area studies programs. Part- management experience in a univer- time teaching on an adjunct basis is sity, hospital or large corporate/ also possible. industrial complex. (Prefer health Duties of the associate director service industry.) will include identification of funding Special skills required: The role of opportunities and preparation of this position is to manage all facilities institutional grant proposals for inter- maintenance activities for the School national and area studies programs, of Medicine in all areas where the advisement of faculty members on central administration is direcdy individual grant applications, recruit- responsible for the facilities and ment for and coordination of campus related support services and to ensure Fulbright programs, coordination of a that certain facilities and services publications program in international managed by the school's reserve units studies, and coordination of confer- are properly maintained. ences, workshops and hospitality for The director of Facilities Manage- visitors in international studies. Salary ment will be responsible for develop- and starting date are negotiable. ing appropriate administrative and or- Applicants should possess an ganizational support structures for the Neediest cases: The University Health Services staff is once again issuing a challenge to all appropriate academic background in a School of Medicine in these areas, departments on the Hilltop and Medical campuses and at the Administrative Service Center to related discipline with a doctorate developing and implementing related participate in the 100 Neediest Cases program co-sponsored by the St. Louis Post-Dispatch and the preferred. They should have adminis- policy and procedures and supervis- United Way. Last year more than 12,000 families in the St. Louis area were directly helped by this annual trative experience, sound skills in oral ing all related personnel. appeal. The Health Services staff is pooling the amount normally spent for departmental holiday season and written communications, and gift-giving and other festivities to make a contribution to the 100 Neediest Cases. Departments prior involvement with fund-raising or In addition to the professional interested in meeting this challenge should inform Gloria W. White, vice chancellor for personnel, at funding agencies. searches, qualified candidates are 889-5990 or through Box 1184. Participating departments will be acknowledged on the University's being sought to fill secretarial, clerical Community Service Honor Roll. Jane L. Kley, a junior in illustration at the University, submitted the Resumes and the names of drawing pictured above in the 100 Neediest Cases Art Competition. Her pen and ink drawing will be individuals willing to serve as refer- and technical positions on the Hilltop on display along with illustrations by other area college students from Jan. 2-7 at the St. Louis Galleria. ences should be mailed by Jan. 30 to: Campus. These positions include the Dean Edward N. Wilson, Chair, Inter- following: national Studies Search Committee, Accounting/Bookkeeping, 4 Washington University, Campus Box positions; Clerical, 1 position; Data Guide for finding help 1187, One Brookings Drive, St. Louis, Processing/Programming, 2 positions; Mo. 63130. Telephone: (314) 889-6843. Drafting, 1 position; Laboratory Tech- nician, 3 positions; Librarian, 4 posi- with personal problems Medical openings tions; Part-time, 5 positions; and Word Assistant Dean for Finance — Re- Processing/Secretarial, 7 positions. As a service to University employees, Financial problems quirements: an MBA, MHA or gradu- Information about these and other the Personnel Office has compiled the Consumer Credit Counseling ate degree in a related management positions is available through the following resource list for those with Service: 1425 Hampton, St. Louis field with a minimum 5 years senior Hilltop Campus Personnel Office, personal problems. 63139, 647-9004. No fee for service. management experience in medical Room 126, North Brookings, 889-5990, Crisis Intervention Resource and school administration. and the Medical Campus Personnel Referral: 647-4357, 9 a.m.-9 p.m., Legal problems Special skills required: The role of Office, 4550 McKinley Ave., 362-7195. Monday through Saturday Legal Aid Society: 625 North this position is to organize and Euclid, St. Louis 63108, 367-1700 administer functions associated with Alcohol and drug abuse Lawyers Reference Service: Civil the management of financial resources Alcoholism Information Center Courts Building, 12th & Market 63101, of the medical school, bearing direct Dependent child National Council on Alcoholism: 8790 622-4995. Clayton Court House, 3rd responsibility for the central adminis- coverage reminder Manchester Road, 63144, 962-3456 floor, 7900 Carondelet, 63105, 889- trative budget of approximately $85 Under Blue Cross/Blue Shield Alliance Alcoholics Anonymous Central 3073. $5 fee to talk to lawyer on duty; million, monitoring the financial Plus, Group Health Plan and Partners Service: 2683 South Big Bend, Room $20 for referral for further services. performance of numerous academic HMO, unmarried dependent children 4, Maplewood 63143, 657-3677 and nonacademic financially autono- are eligible for coverage until the date Al-Anon Family Groups: 2683 mous reserve units and coordinating they marry or the end of the calendar South Big Bend, Room 17, Maple- Reimbursement for the preparation and presentation of year in which they reach age 23, wood 63143, 645-1572 periodic aggregate financial reports whichever comes first. Any unmarried Mid-County Physicians: 11745 child care expense for the entire medical school. dependent child covered under any of Olive Blvd., St. Louis 63141, 567-5011 Any employee who participated in the The assistant dean for finance will Alcohol and Drug Abuse Counsel- Child Care Reimbursement Account be responsible for the administrative these plans who reached age 23 in 1989 may be eligible to continue ing: 1034 South Brentwood, St. Louis during 1989 has until March 31, 1990, management of the medical school's coverage as an individual under the 63117, 725-1616 to submit claims for reimbursement Finance Office, including financial applicable plan for up to 36 months Acid Rescue (Drug Crisis Interven- for qualified child care expenses information systems, selected business with payment of the required pre- tion): 1422 South Big Bend, Richmond incurred during 1989- Any employee support services and development of mium. Contact the Personnel Office at Heights 63117, 645-2900 who participated in the Child Care Re- a clinical systems support staff. In 889-5990 to arrange for continuation Alexian Brothers Hospital: 3933 imbursement Account during 1989 addition, this office will represent the of coverage on unmarried dependent South Broadway, St. Louis 63118, 865- and has funds remaining in his or her school in high-level negotiations with children who reached age 23 in 1989- 3333 account after Dec. 31, 1989, will be third-party payers, affiliated teaching Note that under the TIAA Major provided a statement during January hospitals and other organizations Social service agencies Medical plan, unmarried dependent 1990 showing the balance remaining contracting for services. Family and Children's Service of children are eligible for coverage until in the account. Assistant Dean for Administration Greater St. Louis: 107 South Meramec, age 19, or until age 23 if they are full- — Requirements: an MBA, MHA or Clayton 63105, 727-3235 time students dependent on the graduate degree in a related manage- Jewish Family and Children's covered employee for support. The ment field, with a minimum 5 years Service: 9385 Olive Blvd., University Personnel News eligibility for coverage does not senior management experience in City 63132, 993-1000 Personnel News appears monthly in the Record extend to the end of the calendar year medical school administration. Lutheran Family and Children's and is prepared by Gloria W. White, vice in which the child reaches age 19 or chancellor for personnel and affirmative action, Special skills required: The role of Service: 4625 Lindell, St. Louis 63108, age 23, so it is important to notify the and other members of the Personnel Office. this position is to manage the general 361-2121 Personnel News is designed to keep Washington Personnel Office immediately upon administrative affairs of the medical Family Resource Center (child or University employees and their families the dependent child reaching the school in all areas where the central spouse abuse): 3930 Lindell, St. Louis informed of the benefits and opportunities limiting age to determine if c ontinu- available at the University. administration coordinates activities 63108, 534-9350 ation of coverage is available and provides support services for CALENDAR Dec. 7-16

and Archaeology. Dec. 10-Jan. 14. Gallery of Art, Steinberg Hall. 10 a.m. to 5 p.m. weekdays; LECTURES 1-5 p.m. weekends. For info., call 889-4523. "Washington University Permanent Thursday, Dec. 7 Collection.'' Collection includes European and Noon. Dept. of Genetics Fall Seminars, American art from the post-World War II era, as "Transcriptional Repression and Cell-Type well as Greek coins and terra cotta vases. Control in Yeast," Alexander Johnson, Dept. of Through Dec. 31. Gallery of Art, Steinberg Hall, Microbiology, U. of Calif.-San Francisco. upper and lower galleries. 10 a.m.-5 p.m. Genetics Dept. Library, 816 McDonnell Medical weekdays; 1-5 p.m. weekends. For more info., Sciences Bldg. call 889-4523. 4 p.m. Dept. of Chemistry Seminar, "Faculty Show," featuring photographic works "Structure and Dynamics of Some Ionic Clus- by Stan Strembicki, WU assoc. prof, of art. ters," Mark Crofton, Dept. of Chemistry, U. of Works by other University faculty members also Calif.-Berkeley. 311 McMillen Lab. will be on exhibit. Through Dec. 28. Gallery of 4 p.m. Dept. of Anthropology Colloquium, Art, Steinberg Hall, upper gallery. 10 a.m.-5 p.m. "Feeding and Seed Predation of Pithecia and weekdays; 1-5 p.m. weekends. For more info., Chiropotes," Warren Kinzey, prof., Dept. of An- call 889-4523. thropology, City U. of New York, and dir., "Photographs by Lynne Brown," hosted by Physical Anthropology Program, National WU School of Fine Arts. Brown, the administra- Science Foundation. 101 McMillan Hall. tive coordinator at the Art Institute of Chicago, 6 p.m. Dept. of Germanic Languages and has exhibited throughout the United States and Literatures Lecture, "Preussen 1803-1813 im Japan. Through Dec. 8. Lewis Center, Gallery 'vaterlaendischen Roman': Willibald Alexis, 721, 725 Kingsland Ave. 8 a.m.-4:30 p.m. George Hesekiel, Theodor Fontane," Christian weekdays. For more info., call 725-7014. Grawe, prof, of German, U. of Melbourne, "Looking Back on Mid-Century," featuring Australia. Hurst Lounge, Duncker Hall. 20th-century American and English literary manuscripts. Through Jan. 12, 1990. Olin Friday, Dec. 8 Library, Special Collections, level 5. 8:30 a.m.-5 Noon. Dept. of Cell Biology and Physiology p.m. weekdays. For more info., call 889-5495. Friday Noon Seminar Series, "Angiogenesis in "University of Kentucky Sculpture Exhibit" Xenopus Tadpole Brain," Carl Rovainen, WU part of an exchange program of work by art prof, of cell biology and physiology. Cell students. Through Dec. 17. Bixby Gallery, 2nd Biology Library, 4914 South Bldg. floor, Bixby Hall. 10 a.m.-4 p.m. weekdays; 1-5 4 p.m. Dept of Chemistry Seminar, "Transi- p.m. weekends. For more info., call 889-4643. tion Metal Complexes of Reactive Silicon Inter- mediates," Don Tilley, Dept. of Inorganic Chem- istry, U. of Calif.-San Diego. 311 McMillen Lab. Monday, Dec. 11 FILMS 4 p.m. Dept of Biology Seminar, "Decapenta- plegic Locus of Drosophila," Bill Gelbart, Thursday, Dec. 7 Harvard U. 322 Rebstock Hall. 7 and 9:30 p.m. Filmboard Series, "The Shop Tuesday, Dec. 12 on Main Street." $2. Brown Hall. 4 p.m. Dept of Chemistry Seminar, "Intra- Friday, Dec. 8 and Intermolecular Electronic Processes: Cis- 7 and 9:30 p.m. Filmboard Series, "Princess stilbene Isomerization and Energy Transfer in Bride." (Also Sat., Dec. 9, same times, and Sun., Photosynthesis," John Jean, Dept. of Chemistry, Dec. 10, at 7 p.m.) $2. Brown Hall. U. of Chicago. 311 McMillen Lab. Midnight Filmboard Series, "Monty Python 4 p.m. AIDS Clinical Trials Unit Presents and the Holy Grail." (Also Sat., Dec. 9, same Paintings by Lawrence D. Steefel Jr. will be on display from Dec. 10-Jan. 14 in the Gallery of Art. His Approaches to the Inhibition of HIV time, and Sun., Dec. 10, at 9:30 p.m.) On Fri. "Bloused Figure in Severe Profile," 1988, pictured above, is included in the exhibit, titled "Meditations: Scientific Series, "Inhibition of the HIV and Sat., both the 9:30 p.m. and midnight films The Decade of the Eighties." Protease," Garland R. Marshall, WU prof, of can be seen for a double feature price of $3; pharmacology, and "Attenuation of HIV both Sun. films can be seen for $3. Infections in Vitro by Glucosidase Inhibitors," Tribute to the artist David C. Tiemeier, Dept. of Molecular and Cell Biology, Searle. Cori Aud., McDonnell Medical Steefel paintings to be on exhibit Sciences Bldg. SPORTS Thursday, Dec. 14 Paintings by Lawrence D. Steefel Jr., on the works of Marcel Duchamp, a 10:30 a.m. Olin Library Preservation Year Friday, Dec. 8 Ph.D., Steinberg Professor Emeritus of founder of the post-World War I Lecture Series: "Statewide Preservation 7:30 p.m. Women's Basketball. WU vs. Art History and Archaeology at Wash- "Dadaist" art movement and one of Programs," Lisa Fox, preservation officer of MacMurray. Field House Gym. ington University, will be on exhibit at the most influential artists of the 20th- SELINET. Simon Hall, May Aud. Saturday, Dec. 9 the Gallery of Art in Steinberg Hall century. Steefel has published widely 4 p.m. Dept of Chemistry Seminar, "Hydro- 2 p.m. Men's and Women's Swimming and from Dec. 10-Jan. 14. on Duchamp as well as on other carbon Oxidation Reactions on Single Crystal Diving. WU vs. DePauw U. Millstone Pool. An opening reception will be held subjects, including 17th- and 19th- Surfaces," Jeffrey Roberts, Dept. of Chemistry, 3 p.m. Men's Junior Varsity Basketball. WU Stanford U. 311 McMillen Lab. from 2-5 p.m. Sunday, Dec. 10, in the century paintings. vs. East Central. Field House Gym. 4:15 p.m. Dept of Philosophy Colloquium, gallery. Steefel is admired by his students "Providence and the Problem of Evil," Eleonore Monday, Dec. 11 "We, Pete Steefel's friends and and colleagues for his exuberance in S. Stump, prof., Virginia Polytechnic Institute. 7 p.m. Men's Junior Varsity Basketball. WU colleagues, are honoring him on the teaching. Joni Kinsey, Ph.D., a former Women's Bldg. Lounge. vs. Olney Central. Field House Gym. occasion of his retirement from graduate student who is now an 4:30 p.m. Dept of Mathematics Colloquium, Saturday, Dec. 16 teaching, but this exhibit is a tribute adjunct assistant professor in the "Gain of Regularity for Dispersive Evolution also to Pete Steefel's contributions as department, says, "He gives a sense of 5:30 p.m. Women's Basketball WU vs. U. of Equations," Thomas Kappeler, Brown U. 199 an artist," says Robert Thorp, Ph.D., passion to art that most professors Cupples I Hall. Mo.-St. Louis. Field House Gym. 7:30 p.m. Men's Basketball. WU vs. U. of Mo- associate professor and chair of the can't. As one of the professors I Friday, Dec. 15 st. Louis. Field House Gym. Department of Art History and worked with during my dissertation, I Noon. Dept of Cell Biology and Physiology Archaeology. found he was a great source of Friday Noon Seminar Series, "The LDL The exhibit, tided "Meditations: inspiration for me." Receptor and the Folate Receptor: Contrasting The Decade of the Eighties," features Steefel received his bachelor's Mechanisms of Ligand Internalization," Richard G. Anderson, Dept. of Cell Biology, U. of Texas MISCELLANY recent works that, according to degree from Haverford College in Assistant Professor Robert Jensen, Pennsylvania and his master's and Southwestern Medical School. Cell Biology Friday, Dec. 8 Library, 4914 South Bldg. Ph.D., "evoke qualities of Japanese doctorate in art history at Princeton Noon. Woman's Club Mini-Luncheon Pro- Zen paintings and are closely con- University. gram with the Washington University Chamber Choir Singers presenting a holiday concert. nected to the American Abstract The gallery is open 10 a.m.-5 p.m. Women's Bldg. Cost: $3 for Woman's Club Expressionist movement." weekdays; 1-5 p.m. weekends. During PERFORMANCES members; guests $4. For info., call 725-8254. Perhaps best known as an art the holiday season, the gallery will be Monday, Dec. 11 historian and teacher, Steefel is closed Dec. 22-25 and Dec. 29-Jan. 1. 8 p.m. Performing Arts Dept Presents considered a world-renowned expert For more information, call 889-4523. Dancer Robert Small in concert performing 12:30 p.m. Society of Professors Emeriti solo choreography. Edison Theatre. Cost: Luncheon Meeting, followed by program at general public $8; $5 for senior citizens and 1:30 p.m., "Some Things About Washington students. For more info., call 889-5858. University I Have Learned From Writing its Schools exchange sculptures for display History," Ralph E. Morrow, WU prof, of history and former provost. Whittemore House. For Sculpture students from the University During the 1990 spring semester, members only, to make reservations or more of Kentucky and their professor are a sculpture exhibit by student and MUSIC info., call Earl Shepard at 727-5039. exhibiting their works through Dec. faculty of Washington University will 17 in Bixby Gallery, Bixby Hall, as be displayed at the University of Sunday, Dec. 10 part of an exchange between the two Kentucky in Lexington. Sterritt says 4 p.m. Dept of Music Chamber Choir Calendar Deadline universities. that similar exchanges have been held Concert, with Janet Krupnik directing. Graham The deadline to submit items for Dec. 21-30 The exhibit features works by with other universities, such as Chapel. calendar of the Washington University Record is more than 10 students from the Indiana State at Evansville, but this is Dec. 8. Items must be typed and state time, University of Kentucky sculpture the first time it has been done with date, place, nature of event, sponsor and admis- sion cost. Incomplete items will not be printed. program and the professor of sculp- the University of Kentucky. EXHIBITIONS If available, include speaker's name and identifi- ture, Jack Gron. Gron, a 1976 gradu- Bixby Gallery is open 10 a.m.-4 cation and the title of the event; also include ate of Washington University's School p.m. weekdays and 1-5 p.m. week- "Meditations: The Decade of the Eighties," your name and telephone number. Send items of Fine Arts, is co-organizer of the ends. featuring paintings by Lawrence D. Steefel Jr., to calendar editor, Box 1070, or by electronic show with James Sterritt, professor in For more information on the WU Steinberg Professor Emeritus of Art History mail to p72245PP at WUVMC. the School of Fine Arts. exhibit, call 889-4643. 8