bioRxiv preprint doi: https://doi.org/10.1101/2020.09.06.285254; this version posted September 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1 Yang Shen1, Wei Wang2, Mehari Endale1, Lauren J. Francey3, Rachel L. Harold4, David W. Hammers5, Zhiguang Huo6, Carrie L. Partch4, John B. Hogenesch3, Zhao-Hui Wu2, and Andrew C. Liu1* 1Department of Physiology and Functional Genomics, University of Florida College of Medicine; 2Department of Radiation Oncology and Center for Cancer Research, University of Tennessee Health Science Center; 3Divisions of Human Genetics and Immunobiology, Cincinnati Children's Hospital Medical Center; 4Department of Chemistry and Biochemistry, University of California Santa Cruz; 5Department of Pharmacology and Therapeutics, University of Florida College of Medicine; 6Department of Biostatistics, College of Public Health & Health Professions, University of Florida College of Medicine Running title: NF-κB modifies circadian clock * Correspondence: Andrew C. Liu,
[email protected] Keywords: Circadian clock, inflammation, NF-κB, suprachiasmatic nucleus (SCN), BMAL1 Abbreviations: NF-κB, nuclear factor kappa B; SCN, suprachiasmatic nucleus; IKK, IκB kinase; IκBα, inhibitor of NF-κB; Luc, luciferase; RHD, Rel homology domain; CRD, C-terminal oscillation regulatory domain, TAD, transactivation domain 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.06.285254; this version posted September 6, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved.