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Plant Extracts Rich in Polyphenols: Antibacterial Agents and Natural Preservatives for Meat and Meat Products
Critical Reviews in Food Science and Nutrition ISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: https://www.tandfonline.com/loi/bfsn20 Plant extracts rich in polyphenols: antibacterial agents and natural preservatives for meat and meat products Magdalena Efenberger-Szmechtyk, Agnieszka Nowak & Agata Czyzowska To cite this article: Magdalena Efenberger-Szmechtyk, Agnieszka Nowak & Agata Czyzowska (2020): Plant extracts rich in polyphenols: antibacterial agents and natural preservatives for meat and meat products, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2020.1722060 To link to this article: https://doi.org/10.1080/10408398.2020.1722060 Published online: 11 Feb 2020. Submit your article to this journal Article views: 104 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=bfsn20 CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION https://doi.org/10.1080/10408398.2020.1722060 REVIEW Plant extracts rich in polyphenols: antibacterial agents and natural preservatives for meat and meat products Magdalena Efenberger-Szmechtyk, Agnieszka Nowak, and Agata Czyzowska Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Lodz, Poland ABSTRACT KEYWORDS Plant extracts contain large amounts of bioactive compounds, mainly polyphenols. Polyphenols Polyphenols; plant extracts; inhibit the growth of microorganisms, especially bacteria. Their mechanism of action is still not antibacterial activity; meat fully understood but may be related to their chemical structure. They can cause morphological changes in microorganisms, damage bacterial cell walls and influence biofilm formation. Polyphenols also influence protein biosynthesis, change metabolic processes in bacteria cells and inhibit ATP and DNA synthesis (suppressing DNA gyrase). -
Dcaeee2e425a50757de5fd8dedf
http://dx.doi.org/10.5935/0100-4042.20160063 Quim. Nova, Vol. 39, No. 4, 530-533, 2016 UNREMITTING PROBLEMS WITH CHLOROGENIC ACID NOMENCLATURE: A REVIEW Daniel Kremr, Tomáš Bajer, Petra Bajerová*, Silvie Surmová, and Karel Ventura University of Pardubice, Faculty of Chemical Technology, Department of Analytical Chemistry, Studentská 573, 532 10 Pardubice, Czech Republic Recebido em 08/12/2015; aceito em 12/01/2016; publicado na web em 12/04/2016 Assuntos Gerais This paper summarizes a problematic nomenclature of isomers belonging to chlorogenic acid family since its first occurrence until present. During decades, there have been a high number of articles dealing with the family. Unfortunately, researchers who want to get knowledge about this topic may be strongly confused after reading a few articles. Due to gradual discoveries and isolations of the individual isomers from plenty of matrices and because of the changing system of terminology after these discoveries, discrepancies among articles are common. The cause of this confusion is that the main compound of the family, 5-caffeoylquinic acid (also well- known as chlorogenic acid), was truly called as 3-caffeoylquinic acid before 1976, when new rules for nomenclature were published. Many researchers and also chemicals suppliers, however, keep using the “pre-IUPAC” nomenclature and wrongly call 3-caffeoylquinic acid as chlorogenic acid, the main substituent of the family. Despite there have been some works struggling with this issue, the problem is still appearing. Therefore, the present work was written. Keywords: chlorogenic acid; neochlorogenic acid; nomenclature; coffee. INTRODUCTION nomenclature is still very common, thus the present paper focuses on a possibility of making this problem clear, thus helping further As is well known nowadays, chlorogenic acids (CGAs) are natu- authors to overcome potential misunderstandings of the nomencla- rally occurring compounds found in all higher plants. -
Graphical Abstract CG 18-1-MS
Send Orders for Reprints to [email protected] 3 Current Genomics, 2017, 18, 3-26 REVIEW ARTICLE ISSN: 1389-2029 eISSN: 1875-5488 Impact Factor: 2.43 Established Human Cell Lines as Models to Study Anti-leukemic Effects of Flavonoids BENTHAM SCIENCE Katrin Sak* and Hele Everaus Department of Hematology and Oncology, University of Tartu, Tartu, Estonia Abstract: Despite the extensive work on pathological mechanisms and some recent advances in the treatment of different hematological malignancies, leukemia continues to present a significant challenge being frequently considered as incurable disease. Therefore, the development of novel therapeutic agents with high efficacy and low toxicity is urgently needed to improve the overall survival rate of pa- A R T I C L E H I S T O R Y tients. In this comprehensive review article, the current knowledge about the anticancer activities of Received: May 11, 2015 flavonoids as plant secondary polyphenolic metabolites in the most commonly used human established Revised: November 20, 2015 Accepted: November 27, 2015 leukemia cell lines (HL-60, NB4, KG1a, U937, THP-1, K562, Jurkat, CCRF- CEM, MOLT-3, and MOLT-4) is compiled, revealing clear anti-proliferative, pro-apoptotic, cell cycle arresting, and differ- DOI: 10.2174/138920291766616080316 entiation inducing effects for certain compounds. Considering the low toxicity of these substances in 5447 normal blood cells, the presented data show a great potential of flavonoids to be developed into novel anti-leukemia agents applicable also in the malignant cells resistant to the current conventional che- motherapeutic drugs. Keywords: Antiproliferation, Apoptosis, Cell cycle arrest, Cytotoxicity, Differentiation, Flavonoids, Leukemia, Human cell lines. -
Cytotoxic Activities of Flavonoids from Centaurea Scoparia
Hindawi Publishing Corporation e Scientific World Journal Volume 2014, Article ID 274207, 7 pages http://dx.doi.org/10.1155/2014/274207 Research Article Cytotoxic Activities of Flavonoids from Centaurea scoparia Sayed A. Ahmed and Emadeldin M. Kamel Chemistry Department, Faculty of Science, Beni Suef University, Salah Salem Street, P.O. Box 62514, Beni Suef 62514, Egypt Correspondence should be addressed to Sayed A. Ahmed; [email protected] Received 17 January 2014; Accepted 22 May 2014; Published 11 June 2014 Academic Editor: Diego Savoia Copyright © 2014 S. A. Ahmed and E. M. Kamel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Phytochemical studies on the ethanolic extract of the aerial parts of Centaurea scoparia ledtotheisolationof two new flavonoids, 3 ,4 -dihydroxy-(3 ,4 -dihydro-3 -hydroxy-4 -acetoxy)-2 ,2 -dimethylpyrano-(5 ,6 :7,8)-flavone-3-O-- D-glucopyranoside (1)and3,3,4 -trihydroxy-(3 ,4 -dihydro-3 ,4 -dihydroxy)-2 ,2 -dimethylpyrano-(5 ,6 :7,8)-flavone (2), along with eight known flavonoids isolated for the first time from this plant, cynaroside (3), Apigetrin (4), centaureidin (5), oroxylin A(6), 5,7-dihydroxy-3 ,4 ,5 -trimethoxyflavone (7), atalantoflavone (8), 5-hydroxy-3 ,4 ,8-trimethoxy-2 ,2 -dimethylpyrano (5 ,6 :6,7)-flavone (9), and 3 ,4 ,5,8-tetramethoxy-2 ,2 -dimethylpyrano (5 ,6 :6,7)-flavone (10). The structures of the isolated compounds were elucidated by means of spectroscopic tools including 1D and 2D NMR, UV,IR, and mass spectroscopy. -
WO 2012/159639 Al 29 November 2012 (29.11.2012)
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2012/159639 Al 29 November 2012 (29.11.2012) (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A23L 1/30 (2006.01) A61K 36/48 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, A61K 36/185 (2006.01) A61K 36/8962 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61K 36/63 (2006.01) A61K 36/54 (2006.01) HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, A61K 36/23 (2006.01) A61K 36/71 (2006.01) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, A61K 36/9066 (2006.01) A61K 36/886 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, A61K 36/28 (2006.01) A61K 36/53 (2006.01) OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, A61K 36/82 (2006.01) A61K 36/64 (2006.01) SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 36/67 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/EG20 12/0000 18 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 22 May 2012 (22.05.2012) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: ML, MR, NE, SN, TD, TG). -
Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin
Review Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin Rashida Ginwala, Raina Bhavsar, DeGaulle I. Chigbu, Pooja Jain and Zafar K. Khan * Department of Microbiology and Immunology, and Center for Molecular Virology and Neuroimmunology, Center for Cancer Biology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA; [email protected] (R.G.); [email protected] (R.B.); [email protected] (D.I.C.); [email protected] (P.J.) * Correspondence: [email protected] Received: 28 November 2018; Accepted: 30 January 2019; Published: 5 February 2019 Abstract: Inflammation has been reported to be intimately linked to the development or worsening of several non-infectious diseases. A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. For centuries, flavonoids and their preparations have been used to treat various human illnesses, and their continual use has persevered throughout the ages. This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics. Additionally, inflammation in the central nervous system (CNS) due to diseases such as multiple sclerosis (MS) gives ready access to circulating lymphocytes, monocytes/macrophages, and dendritic cells (DCs), causing edema, further inflammation, and demyelination. -
Characterization of Phytochemicals in Berry Fruit Wines Analyzed
foods Article Characterization of Phytochemicals in Berry Fruit Wines Analyzed by Liquid Chromatography Coupled to Photodiode-Array Detection and Electrospray Ionization/Ion Trap Mass Spectrometry (LC-DAD-ESI-MSn) and Their Antioxidant and Antimicrobial Activity Agata Czy˙zowska* , Agnieszka Wilkowska , Agnieszka Staszczak (Mianowska) and Agnieszka Nowak Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 171/173 Wolczanska Street, 90-924 Lodz, Poland; [email protected] (A.W.); [email protected] (A.S.); [email protected] (A.N.) * Correspondence: [email protected] Received: 29 September 2020; Accepted: 26 November 2020; Published: 1 December 2020 Abstract: Fruits are a valuable source of phytochemicals. However, there is little detailed information about the compounds contained in fruit wines. In this study, wines from six different berries were analyzed using HPLC-DAD-ESI-MSn. About 150 compounds were identified, including anthocyanins (34), hydroxycinnamic acids (12) and flavonols (36). Some of the compounds were identified for the first time in berry wines. The blackberry wines were found to contain the largest number of bioactive compounds (59). Elderberry wines where the richest source of polyphenols (over 1000 mg/L) and contained the largest amounts of all of the analyzed groups of compounds (hydroxycinnamic acids, anthocyanins and flavonols). The lowest concentration of polyphenols was observed in the wines made from cranberries and bilberries (less than 500 mg/L). The antioxidant activity was determined in relation to ABTS+, DPPH, and FRAP. The highest values were observed in the blackberry wines, and the lowest for the cranberry wines. -
A GDSL Lipase-Like from Ipomoea Batatas Catalyzes Efficient
ARTICLE https://doi.org/10.1038/s42003-020-01387-1 OPEN A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris Sissi Miguel1,6, Guillaume Legrand2,6, Léonor Duriot1, Marianne Delporte2, Barbara Menin3, Cindy Michel1, 1234567890():,; Alexandre Olry3, Gabrielle Chataigné2, Aleksander Salwinski1, Joakim Bygdell4, Dominique Vercaigne2, ✉ ✉ ✉ Gunnar Wingsle5, Jean Louis Hilbert 2,7, Frédéric Bourgaud1,7 , Alain Hehn 3,7 & David Gagneul2,7 The synthesis of 3,5-dicaffeoylquinic acid (3,5-DiCQA) has attracted the interest of many researchers for more than 30 years. Recently, enzymes belonging to the BAHD acyl- transferase family were shown to mediate its synthesis, albeit with notably low efficiency. In this study, a new enzyme belonging to the GDSL lipase-like family was identified and proven to be able to transform chlorogenic acid (5-O-caffeoylquinic acid, 5-CQA, CGA) in 3,5- DiCQA with a conversion rate of more than 60%. The enzyme has been produced in different expression systems but has only been shown to be active when transiently synthesized in Nicotiana benthamiana or stably expressed in Pichia pastoris. The synthesis of the molecule could be performed in vitro but also by a bioconversion approach beginning from pure 5-CQA or from green coffee bean extract, thereby paving the road for producing it on an industrial scale. 1 Plant Advanced Technologies, Vandœuvre-lès-Nancy, France. 2 UMR Transfrontalière BioEcoAgro N° 1158, Univ. Lille, INRAE, Univ. Liège, UPJV, ISA, Univ. Artois, Univ. Littoral Côte d’Opale, ICV – Institut Charles Viollette, 59000 Lille, France. 3 UniversitédeLorraine-INRAE,LAE,54000Nancy,France. -
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells in Vivo and in Vitro by Activating the Mitochondrial Pathway
Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 9922059, 13 pages https://doi.org/10.1155/2021/9922059 Research Article Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway Yuan Cai ,1 Qing Du ,1 Tian-Hao Deng ,1 Bing-Bing Shen ,1 Yan-Mei Peng ,1 Pu-Hua Zeng ,1 and Song-Ren Yu 2 1Institute of Traditional Chinese Medicine, Hunan Academy of Chinese Medicine, Changsha 410006, China 2Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China Correspondence should be addressed to Pu-Hua Zeng; [email protected] and Song-Ren Yu; [email protected] Received 9 March 2021; Revised 28 May 2021; Accepted 6 July 2021; Published 15 July 2021 Academic Editor: Yu CAI Copyright © 2021 Yuan Cai et al. 0is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Huxie Huaji (HXHJ) Ointment is a famous traditional Chinese medicinal prescription and is commonly used for the clinical treatment of hepatocellular carcinoma by boosting immunity and detoxification. However, the scientific evidence for the effect of HXHJ Ointment on hepatocellular carcinoma and the underlying molecular mechanism are lacking. 0e present study aimed to identify the effects of HXHJ Ointment on hepatocellular carcinoma in vitro and in vivo as well as investigating the mechanistic basis for the anticancer effect of HXHJ ointment. First, liquid chromatography-mass spectrometry was used to verify the composition of HXHJ Ointment and quality control. -
Plantago Media L.—Explored and Potential Applications of an Underutilized Plant
plants Review Plantago media L.—Explored and Potential Applications of an Underutilized Plant Radu Claudiu Fierascu 1,2, Irina Fierascu 1,3,* , Alina Ortan 3 and Alina Paunescu 4 1 National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, 060021 Bucharest, Romania; fi[email protected] 2 Department of Science and Engineering of Oxide Materials and Nanomaterials, University “Politehnica” of Bucharest, 011061 Bucharest, Romania 3 University of Agronomic Sciences and Veterinary Medicine of Bucharest, 011464 Bucharest, Romania; [email protected] 4 Department of Natural Sciences, University of Pitesti, 1 Targu din Vale Str., Pitesti, 110040 Arges, Romania; [email protected] * Correspondence: [email protected] Abstract: The search of valuable natural compounds should be directed towards alternative vegetal resources, and to the re-discovery of underutilized plants. Belonging to the Plantaginaceae family, the hoary plantain (Plantago media L.) represents one of the lesser studied species from the Plantago genus. The literature study revealed the under-utilization of the hoary plantain, a surprising aspect, considering its widespread. If the composition of Plantago media L. is rather well established, its applications are not nearly studied as for other Plantago species. The goal of the present paper is to summarize the findings regarding the applications of P. media, and, having as starting point the applications of related species, to propose new emerging areas of research, such as the biomedical applications validation through in vivo assays, and the evaluation of its potential towards indus- trial applications (i.e., development of food or personal care products), pisciculture or zootechny, phytoremediation and other environmental protection applications, or in the nanotechnology area Citation: Fierascu, R.C.; Fierascu, I.; (materials phytosynthesis). -
Flavonoids: Structure–Function and Mechanisms of Action and Opportunities for Drug Development
Toxicological Research Toxicol Res. eISSN 2234-2753 https://doi.org/10.1007/s43188-020-00080-z pISSN 1976-8257 INVITED REVIEW Flavonoids: structure–function and mechanisms of action and opportunities for drug development Stephen Safe1 · Arul Jayaraman2 · Robert S. Chapkin3 · Marcell Howard1 · Kumaravel Mohankumar1 · Rupesh Shrestha4 Received: 10 November 2020 / Accepted: 4 December 2020 © Korean Society of Toxicology 2021 Abstract Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and dietary consumption of these structurally diverse compounds is associated with multiple health benefts including increased lifespan, decreased cardio- vascular problems and low rates of metabolic diseases. Preclinical studies with individual favonoids demonstrate that these compounds exhibit anti-infammatory and anticancer activities and they enhance the immune system. Their efectiveness in both chemoprevention and chemotherapy is associated with their targeting of multiple genes/pathways including nuclear receptors, the aryl hydrocarbon receptor (AhR), kinases, receptor tyrosine kinases and G protein-coupled receptors. However, despite the remarkable preclinical activities of favonoids, their clinical applications have been limited and this is due, in part, to problems in drug delivery and poor bioavailability and these problems are being addressed. Further improvements that will expand clinical applications of favonoids include mechanism-based precision medicine approaches which will identify critical mechanisms of action -
Polyphenol Profile and Antimicrobial and Cytotoxic Activities of Natural
processes Article Polyphenol Profile and Antimicrobial and Cytotoxic Activities of Natural Mentha × piperita and Mentha longifolia Populations in Northern Saudi Arabia Hosam O. Elansary 1,2,3,* , Agnieszka Szopa 4,* , Paweł Kubica 4, Halina Ekiert 4, Marta Klimek-Szczykutowicz 4, Diaa O. El-Ansary 5 and Eman A. Mahmoud 6 1 Plant Production Department, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2 Floriculture, Ornamental Horticulture, and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt 3 Department of Geography, Environmental Management, and Energy Studies, University of Johannesburg, APK campus, Johannesburg 2006, South Africa 4 Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland; [email protected] (P.K.); [email protected] (H.E.); [email protected] (M.K.-S.) 5 Precision Agriculture Laboratory, Department of Pomology, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria 21545, Egypt; [email protected] 6 Department of Food Industries, Faculty of Agriculture, Damietta University, Damietta 34517, Egypt; [email protected] * Correspondence: [email protected] (H.O.E.); [email protected] (A.S.); Tel.: +966-851216322 (H.O.E); +48-126205430 (A.S.) Received: 25 March 2020; Accepted: 16 April 2020; Published: 20 April 2020 Abstract: New sources of polyphenols with anticancer, antioxidant, and antimicrobial properties in arid environments are critical for the development of alternative medicines and natural remedies. This study explored the polyphenol profiles and biological activities of methanolic leaf extracts from natural Mentha piperita and Mentha longifolia populations in northern Saudi Arabia.