This Bibliography Is One in a Series on Smoking and Smoking and Health

DOCUMENT RESUME

ED 047 988 SE 010 867

TITLE Bibliography on Smoking and Health, 1969 Cumulation, Part 2. INSTITUT1nN Public Health Service (DHEW), Rockville, Md. National Clearinghouse for Smoking and Health. REPORT NO PHS-Bib-5er-45; PHS-Pub-1124 PUB DATE Jun 70 NOTE 367p. AVAILABLE FRCM Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 (PHSP-1948, $1.25)

BURS PRICE EDRS Price MF-$0.65 HC Not Available from 1DRS. DESCRIPTORS Abstracts, Annotated Bibliographies, *Bibliographies, *Health, Indexes (Locaters), *Reference Materials, *Smoking

ABSTRACT This bibliography is one in a series on smoking and health and supplements a preceding volume entitled ',Bibliography cn Smoking and Health-1969.0 It includes all of the items added to the Technical Information Center of the National. Clearinghouse for Smoking and Health from January through December 1969. Eleven sections contain citations and annotations under the following typics: chemistry, pharmacology and toxicology; mortality and morbidity; neoplastic diseases; non-neoplastic respiratory diseases; cardiovascular diseases; other diseases and conditions; behavioral research; tobacco economics; bills and legislation; educational and research programs; and smoking withdrawal treatment. Indexes are included for individual and corporate authors and for subjects. English language abstracts of foreign items are also provided. (BL) 03 a)

CUMULATION

PART II .

U.S. DEPARTMENT OF HEALTH, EDUCATION WELFARE OFFICE OF EDUCATION THIS DOCUMENT HAS BEEN MIRGDUCED EXACTLY AS RECEIVED FACMIHE PERSON OR ORGANIZATION ORIGINATING IT PONES OF VIEW OR OPINIONS STATED DO N01 PIECES SARILY RE PRESE NI OFFICIAL OFFICE OF IDLI CATION POSITION OR POLICY

MI1110( Itill'HY ON SUMO AND HEALTH A A

P.',ITT! NT (1F (F)I !ON.vIrl FAIT 141,1'th co a)

1%; O O UJ

v v v V v BIBLIOGRAPHY ON SMOKING AND HEALTH

With English language abstracts of foreign items

10 CUMULATION PART II

U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service Health Services and Mental Health Administration Regional Medical Programs Service National Clearinghouse (or Smoking and Health Rockville, Maryland20852 PREFACE

This Bibliography includes all of the items added to the Technical Information Center of the National Clearinghouse for Smoking and Health from January through December 1969. It is a supplement to the preceding volume of the Bibliography on Smoking and Health1969. Earlier volumes still available for purchase through the Superintendent of Documents, Government Printing Office, include the 1968 and 1969 volumes. These may be ordered by requesting from the Government Printing Office, Public Health Service Publication No. 1124, Bibliography Series No. 45, plus the year desired.

The material collected for use in preparing the 1964 publication, Smoking and Health, Report of the Advisory Committee to the Surgeon General of the Public Health Service, formed the basis for the first Bibliography published in this series. Subsequent bibliographies have been used in preparing the Surgeon General's Report, The Health Consequences of Smoking, A Public Health Service Review: 1967, and the 1968 and 1969 supplements. The 1967, 1968 and 1969 reports are available from the Government Printing Office.

In order to adjust the titles of this continuing bibliography to the actual period of collection, this volume will be called the 1969 Bibliography on Smoking and Health, Part II. In the future, the year number of the Bibliography will represent the year in which the items in the Bibliography were added to the collection.

This Bibliography has an index of individual and corporate authors and one of subjects. To find items, consult the index, choose the serial number and note its prefixed letter. Turn to the appropriate subject section as identified by the prefix and locate the desired citation.

Fc,sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 - Price 09.25 fi 5 17 ) CONTENTS

Page

Section A.Chemistry, Pharmacology and Toxicology 1

Section B.Mortality and Morbidity 93

Section C.Neoplastic Diseases 111

Section 1).Non.Neoplastic Respiratory Diseases 165

Section I..Cardiovascular Diseases 202

Section F.Other Diseases and Conditions 250

Section G.Behavioral Research 268

Section H.Tobacco Economics 272

Section 1.Bills and Legislation 273

Section J.Educational and Research Programs 278

Section K.Smoking Withdrawal Treatment 303

Individual and Organization Index 308

Subject Index 331 SECTION A. CHEMISTRY, PHARMACOLOGY AND TOXICOLOGY

A 10191 A 10193 Shabad, M. L-M. Medecine at Hygiene. SUBSTANCES CARCINOGENES DtNS L'EFFET DE LA FUME DE CIGARETTES L'ENVIRONNEMENf DE L'HOMME; ET DE LA NICOTINE SUR LA SECRETION LES VOIES DEPREVENTION DU CANCER CORTICO-SURRENALIENNE. (EFFECT OF (EN PARTICULIER DU POUMON). CIGARETTE SMOKE AND NICOTINE ON CARCINOGENIC SUBSTANCES IN MAN'S CORTICO-ADRENAL SECRETION.) Meciscine ENVIRONMENT] MEANT FOR PREVENTING et Hygiene 26(934)M365-6, Aug-TS, rsse, CANCER (ESPECIALLY LUNG CANCER).) Wench (Abs.) 102 Medical 220(32)t215-30, Aug 14.1968, French (Abs.) Five men and 4 women, 22 to 30 years old, all heavy smokers, smoked Hygienic protection against cancer 4 filter cigarettes in 1/2 hour; 15 is possible by detecting the sources normal subjects of the same cgs of pollution by carcinogenic sub- served as controls. In smokers, 30 stances in the human environment minutes after the last cigarette, and in their maximal reduction. The there was a 47 percent rise in 11-0H safety measures include the exclusion corticosteroids (11-0HUS); two hours of known carcinogens in Industrial later, the levels were lower but were fabrication, prevention ct air still above normal. Cigar or pipe pollution by aromatic hydrocarbons, smoking did not cause an elevation and by systematic control of workers' of 11 -OHCS. Six dogs were injected health. The primary sources of intravenously with 0.9 mg/kg of atmospheric pollution by benzopyrene nicotine bitartrate. This was are smoke from heating plants, followed by a 64 percent rise of 11 -OHCS, Industrial wastes and exhaust gases 1 hour after the administration of automobiles. Automobile exhaust of nicotine. The rise in rats was gases can be controlled by filters 58 percent. The levels of or by special neutralizers. Smoke cholesterol were almost constant in from diesel motors CEO be reduced these experiments. Two explanations by special additives to the fuels have been suggested for the mechanism which can reduce the quantity of of this nicotine effect. Knowledge of benzopyrene in the exhaust gases. this effect indicates that cigarette Pollution of the atmosphere can also smoking should be controlled when one be accomplished through the mediur seeks to evaluate effects of drugs, of smoking tobacco.Hazards from external stress or different diseases this source can be reduced by smoking on cortico-adrenal metabolism. less, by using filters, by leaving longer cigarette butts and by not inhaling. Prohibition against A 10194 smoking in public places and campaigns Buu Moi, N. P., Hien, D-P., and Hleu, warning against beginning the slacking H-T. habit are desirable measures. The STIMULATION DE LA SYNTHESE IN VIVO DE LA destruction of benzopyrene in soil ZOXAZOLAMINE-HYDROXYLASE CHB! LE gAT PAR by certain micro-organisms has also LES CONDENSATS DE PUREE DE TABAC ET DE been demonstrated.This fact has a POLLUANTS ATMOSPHERIOIVES. (STIMULATION certain importance since benzopyrene OF IN mg SYNTHESIS OF ZOXAZOLAMINE- in soil can be taken up by growing HITOXYLASE IN RATS BY CONDENSATES OP plants which are then eaten by man. TOBACCO SMOKE AND ATMOSPHERIC POL- The ingestion of benzopyrene from LUTANTS.) Comptes R ndus Hebdomadairet smoked foods may be reduced by the des Seances de l'Aca em a des Sciences use of "liquid smoke". Experiments 7g7(8)r868-737 Aug-19, I9M-French in this regard are encouraging. (Abs.) Pesticides which have carcinogenic action should be replaced by less The zoxazolamine-hydroxylase test hazardous agents. Regarding drugs hea been applied for research on the Which may be utilized during Illness inductor effect of cigarette smoke or pregnancy, a report of the World condensates prepared by SEITO and of the Health Organization states that activity of bentenic extracts of minimal permissible doses of such atmospheric particulate pollutants from agents do not exist. several industrial American cities. The A 10194 (continued) A 10197 (continued) tests were carried out on 3-month-old carcinogenic and noncarcinogenic hydro- Wistar rats who had been fed a vitamin- carbons on the subcellular granules of rich synthetic diet. The test tars in the cells was expressed by a significant neutral corn oil were infected intra- decline in the antioxidation activities peritoneally to each animal in doses of in the dissolved fraction and all 1040 mg tar/kg of body weight; 24 mitochondriel fractions. The specific hours later, both treated and control chamical character of the reactions rats received uniform intraperitoneal of carcinogenic and noncarcinogenic injections of Zoxazolamine (90 mg/kg) hydrocarbons was manifested only during and the duration of paralysis measured. reactions with lysozymes of cells and The results demonstrated very clearly did not depend on the nature of the sol- that cigarette tars and atmospheric vents. On the basis of these investiga- pollutants can stimulate the in vivo tions one could assume that the primary synthesis of zoxazolamine-hydrox7TEEe formation of the antioxidative complex and that this activity could serve in during the reaction of carcinogens with the evaluation of biologically-significant substrate cells proceeded only in polycyclic compounds present in the lysozymal fractions of the organoida of samples. cells.

A 10197 A 10199 Tarusov, B. N., Lomsadze, B. A., Tsartsidze, Samoylovich, L. N. and Red'kin, Yu. R. M. A.

3Am43HEHOE ATHOO4fRiTO 1303g0A 3,4-SEH3rI1inkel 0 cnEtpoll4ECK04 B3A,140,LIEMTB141 yrIEBoxecattt nPE,TiFysfThistii HE.TExiffitiECKOn nPOMAWEr+CCV. icieuLFOCEKe C /1430001001-14 KJETOK. ZAORYAZNENTiE ATMOSFERN000 YOZDUKHA 3,4- BENZPIRENOM PREDRIYATIYAMI NEFTE- 0 SPETSIFICHESKOM VZAIMODEYSTVII KHIMICHESKOY PROMYSHLENNOSTI. (ATMO- UOLEVODORODNYKH KANTSEROGENOV S SPHERIC POLLUTION WITH 3,4-BENZO- LIZOSOMAMI KLETOK. (THE SPECIFIC PHYRENE BY THE PETROCHEMICAL REACTIONS OF HYDROCARBON CARCINOGENS INDUSTRY.)Oi iena i Sanliarlia WITH LYSOZYMES OF CELLS. Doklad (9)s10-4,19 ussran (Abs.j Akademii Nauk SSSR 178(6 :1418 -20, ft-GFasiTER 3757.) Discharges of the Orozny (Al- chemical plants proved to affect the A chemiluminescent method was 3,4-benzpyrene content in the atmo- utilized for the evaluation of the sphere. In the radius of 2 km oxidation processes in subcellular frac- around the oil-refining plants there tions cf rat liver homogenate to which was a stable air pollution with 3,4- carcinogens were added. The testa were benzpyrene (0.15-2.2 mkeloo m3).The carried out on 4 mitochondrial fractions, shops, where high temperature 1 lysozymal fraction and 1 dissolved processes proceed, were the most fraction of the liver. The activity of significant sources of Pollution noncarcinogenic anthracene caused a (3.34-40 mkg/100 m3). The investigation decreased activity of all mitochondrial data obtained may be used for sub- fractions of the liver. A noticeablY stantiating the radius of the sanitary lower antioxidation activity was also protection zone. (Author Abstract) observed in the lysozymal fraction. No decreased antioxidative properties were observed in the dissolved fraction A 10201 in comparison with the controls. Schmahl, D. Methylcholanthrene however affected the METHODISCHE ASPEKTE BE/ UNTERSUCHUNGEN fractions differently. There was a ZUR CARCINOOENESE UND ZUR CHEMOTHERAPIE decreased number of antioxidants in the VON TUMOREN. (METHODICAL ASPECTS IN THE mitochondria) fractions and in the INVESTIGATIONS ON CARCINOOENESIS AND THE dissolved fraction but a significant CHEMOTHERAPY OF TUMORS.) Planta Mediae increase in antioxidation properties in 11(14)13-12, Jun 1968, Oerigni-Th57T--- the lysozymal fraction. DMBA and 1,2-benzanthracene also increased the The arrangement and the testing of antioxidation capabilities only in the chemical carcinogenesis in animals were lysozymal fraction but there was an described. The differences between local obvious decrease in the antioxidation and resorptive-acting substances were ex- capabilities in all other fractions. The plained. The basis for the selection of general consequences of the activity of particular animals for special studies, A 10201 (continued) A 10205 the dosage, duration and evaluation of Turusov, V. S. the tests were also discussed. The importance of the investigations in car- KAHUEPOrEttKE iffICTI3Ht. 7,124141ETW6E113(A)AMTPALIENA cinogenesis for application to clinical HA 1113EABAPVITEAM CEN4EN1Y10 KGmO'. studies was explained. Methodical questions regarding cancer chemo- KANTSEROOENNOE DEYSTVIYE 7,12- therapy with special emphasis on the DIMETILBENZ(a)ANTRATSENA NA application of autochthonous tumors as PREDVARITELTO OBLUCHENNUYU KOZHU. test models were also considered. It (CARCINOGENIC ACTION OF 7,12- was concluded that the side-effects of DIMETHYLBENZ(a)ANTHRACENE ON anticancer agents should be studied more PREVIOUSLY IRRADIATED SKIN.) Precisely in order to ascertain both the Voprosy Onkolo 11 14(8):66-71, 1968, acute injury and that expected only Russian s. after years of chronic administration. Prolonged application of 0.0025 percent of a benzol solution of A 10202 7,12-dimethylbenz(a)anthracene (DMBA) Luganskaya, L. N., Krasnokotskaya, E. B.. on previously irradiated skin of mice and JasinskaJa, L. 13. resulted in increased chemical lAUXVIOULANME SKCTPAKTATAWHomrtUll LAS carcinogenesis expressed by a shorter AINrsAWALVM 7AWA. average latent period in the emergence of tumors, a larger percentage of ISPOL,ZOVANIE EKSTRAKTA TABACHNOY animals with tumor, a greater number DLYA AROMATIZATSII TABAKA. (THE USE of tumors on an animal, and a greater OF TOBACCO DUST EX(Pa RACTFoR AROMATIZINO incidence of precancerous conditions TOBACCO. Tabak, a50-3,rt* 1967, and malignant tumors. The incidence Russian AbI71- of malignant tumors in groups with combined action at the end of the The recent work of the Krasnodor observation period substantially Scientific Investigations institute of exceeded the total incidence of the Food Industry was described. carcinomas and sarcomas appearing after Extraction of the aromatic principles separate administration of radiation Of tobacco dust using carbon dioxide and DMBA, indicating stimulation of yielded a light-brown viscous mass with chemical carcinogenesie but with no a heavy tobacco aroma and the odor of clear additive effect.Reinforcement dried fruits and honey. The yield was of chemical carcinogenesis in previously 1-1.5 percent. The extract contained irradiated akin of mice could be 5.45 percent alkaloids precipitated by linked with longer retention of the silicotungstic acid with 1.2 percent chemical carcinogenic substances. nicotine. Treatment of the extract with organic solvents (benzene petroleum ether, ethyl ether and acetone) A 10205 and carbon dioxide yielded an average Mitolo-Chieppa, D. of 65-71 percent of the neutral fraction SUL MECCANISMO DI UNA AZIONE of the tobacco extract. The neutral VASOH/LASSANTE DELLA NICOTINA. fraction (sum of the neutral substances) (MECHANISM OF A VASODILATINO ACTION was a yellowish-orange syrupy mass with OP NICOTINE.) Bollettino della Societe a very pleasant aroma of tobacco, honey Italians di Dioniiir-fim ntale and blossoms. The effect of th1/4. 44(10)180=3, May of, , a an tobacco extract and the neutral sub- (Abs.) stances of tobacco tars on the aroma of tobacco smoke was investigated Longitudinal strips of the arterial by the addition of alcoholic and ether wall of human umbilical cord treated solutions on the neutral skeleton of with 2-20 micrograms/m1 of nicotine tobacco. It was determined that 1 invariably showed a loss in tone. An percent by weight strengthened the increase in tone was never recorded. aroma; optimal concentrations were 1-2.5 The administration of the same dosage percent. Higher concentrations inten- of nicotine at 15 minute intervals sified the blossom or fruity odor but for a total of 6 or 7 tests always the final product was uncharacteristic of caused a relaxation of the same entity. the tobacco aroma.The article also The data confirmed the existence of a presents the reaults of the addition vasodilating lotion of nicotine. Such of different concentrations of ether relaxation is not mediated through the solutions of tobacco extracts or the vegetative nervous system (since the neutral fractions to several grades of preparation lacks any nervous fiber) tobacco. through liberation of vaeodilating

3 A 10205 (continued) A 10223(continued) substances by the atsolute absence of Health Service, National Cancer a phenomenon of tachyphylaxis. It Institute Monograph No. 28, Jun was therefore concluded that nicotine 1968, pp. 97-111. causes relaxation of the vascular mscle fibers by direct action. A 10224 Stedman, R. L. A 10207 NICOTINE REDUCTION IN TOBACCO AND Hoffmann, D. and Rathkunp, O. TOBACCO SMOKE. Ins Wynder, E. L. CHEMICAL STUDIES ON TOBACCO SMOKS. aid Hoffmann, D. (Editors).Toward V. QUANTITATIVE DETERMINATION OF A Less Harmful Cigarette. U.S. CHLORINATED HYDROCARBON INSECTICIDES Department of Health, Education, and IN CIGARETTE TOBACCO AND ITS SM)KE. Welfare, Public Health Service, Beitrage zur Tabakforschnas 4(5): National Cancer Institute Mongraph -14, Jur19Ti$". No. 28, Jun 1968, pp. 113-9.

A 10210 A 10225 Nesemann, E., Schroder, R., and Mitchell, R. I. and Gieseke, J. A. Seehofer, F. MECHANICAL FILTRATION: A REVIEW OF METHODENZURQUANTITATIVENBESTIMMUNG FILTRATION MECHANISMS PERTINENT TO VON INSEKTIZIDEN IN TABAK UND CIGARETTE SMOKE. In: Wynder, E. L. TABAYRAUCH. II. MITTEILUNGs ZUR and Hoffmann, D. (Editors). Toward BESTIMMUNG VON CARBAMAT-INSEKTIZIDEN. A Less Harmful Cigarette. U.S. (METHODS FOR THE QUANTITATIVE Department of Health, Education, and DETERMINATION OF INSECTICIDES IN Welfare, Public Health Service, National TOBACCO AND TOBACCO SMOKE. PART II. Cancer Institute Monograph No. 28, ON THE DETERMINATION OF CARBAMATE Jon 1968, pp. 121-52. INSECTICIDES.) Beitrage zur Tabakforsch 415):197-256; Jul 1968, 5erman(Abs.ung) A 10226 Moshy, R. J. and Halter, H. M. A thin-layer chromatographic method RECONSTITUTED-TOBACCO-LEAF TECHNOLO1Y: has been developed for the qualitative A TOOL FOR TOBACCO-SMOKE MODIFICATION. and quantitative determination of In: Wynder, E. L. and Hoffmann, D. carbamate residues on tobamco. The (Editors). Toward A Less Harmful method's inferior limit of detection Cigatatte. U.S. Department of Health, is 80 ng for Carbaryl and 200 ng for Education, and Welfare, Public Health Undone. The coefficient of variation Service, National Cancer Institute of the results is 5.3 percent for Monograph No. 28, Jun 1968, pp. Carbaryl and 7.7 percent for Undene. 133 -48. (Author Abstract) A 10227 A 10222 Hoffmann, D. and Wynder, E. L. Moore, O. E. and Bock, F. O. SELECTI/E REDUCTION OF THE "TAR' AND NICOTINE LEVELS OF AMERICAN TUMORIGENICITY OF TOBACCO SMOKE. CIGARETTES. In:Wynder, E. L. and EXPERIMENTAL APPROACHES. In Wynder, Hoffmann, D. (Editors). Toward a E. L. and Hoffmann, D. (Editcra). Less Harmful Cigarette. U.S. Depart- Toward A Less Harmful Cigarette. ment of Health, Education, and Welfare, U.S. Department of Health, Education, Public Health Service, National and Welfare, Public Health Service, Canner Institute Monograph No. 28, National Cancer Institute Monograph Jun 4968, pp. 89 -94. No. 28, Jun 1968, pp. 151-72.

A 10223 A 10223 Tso, T. C. Van Duuren, B. L. Sivak, A., Langseth, EFFECT CF FARM PRODUCTION PRACTICES L. Ooldschmidt, B. M., and Segal, A. ON NICOTINE AND TOTAL PARTICULATE INITIATORS AND PROMOTERS IN TOBACCO MATTER IN CIGARETTE SMOKE. In: CARCINOOENESIS. ;nt Wynder, E. L. Wynder, a. L. and Hoffmann, D. and Hoffmann, D. (Editors).Toward (Editors). Toward a Less Harmful A Lees Harmful Cigarette. U.S. Depart- Cigarette.U.S. Department of ment of Health, Education, and Welfare, Health, Education, and Welfare, Public Public Health Service, National Cancer Institute Monograph No. 28, Jun 1968, pp. 175-00.

4 A 10229 A 10234 (continued) Johnson, D. E., Millar, J. D., and Cigarette. U.S. Department of Rhoades, J. W. Health, Education, and Welfare, NITROSAMINES IN TOBACCO SMOKE. in: Public Health Service, National Wynder, E. L. and Hoffmann, D. Cancer Institute Monograph No. 28, (Editors). Toward A Less Harmful Jun 1968, pp. 215-20. Cigarette. U.S. Department of Health, Education, and Welfare, Public Health Service, National Cancer Institute A ) 0235 Monograph No. 28, Jun 1968, pp. Rylander, R. 161-9. RELATIVE ROLE OF AEROSOL AND VOLATILE CONSTITUENTS OF CIGARETTE SMOKE AS AGENTS TOXIC TO THE RESPIRATORY A 10230 TRACT. In: Wynder, E. L. and Cooper, J. T., Forbes, W. F., and Hoffmann, D. (Editors).Toward A Less Robinson, J. C. Harmful Cigarette. U.S. Department FREE RADICALS AS POSSIBLE CONTRIBUTORS of Health, Education, and Welfare, TO TOBACCO -SMOKE CARCINOOENESIS. In: Public Health Service, National Wynder, E. L. and Hoffmann, D. (Editors). Cancer Institute Monograph No. 28, Jun Toward A Less Harmful Cigarette.U.S. 1968, pp. 221-9. Department of Haalth, Education, and Welfare, Public Health Service, National Cancer Institute Mongraph A 10236 No. 28, Jun 1968, pp. 191-7. Curphey, T. J. CARB0XIMOOLOBIN IN RELATION TO SMOKING. In: Nynder, E. L. and A 10231 Hoffmann, D. (Editors).Toward A Casarett, L. J. Less Harmful Cigarette.U.S. Depart- ROLE OF RADIOACTIVE SUBSTANCES IN ment of Health, Education, and EFFECTS OF SMOKING. In: Wynder, Welfare, Public Health Service, E. L. and Hoffmann, D. (Editors). National Cancer Institute Monograph Toward A Less Harmful Cigarette. No. 28, Jun 1968, pp. 231-5. U.S. Department of Health, Education, and Welfare, Public Health Service, National Cancer Institute Monograph A 10237 No. 28, Jun 1968, pp. 199-207. George, T. W. SELEVANE REMOVAL OP COMPONENTS OF TOBACCO SMOKE BY FILTRATION. In: A 10232 Wynder, E. L. and Hoffmann, D. Tto, T. C. (Editors). Toward A Less Harmful POLONIUM-210 AND LEAD-210 IN TOBACCO. Cigarette. U.S. Department of In: Wynder, E. L. and Hoffmann, D. Health, Education, and Welfare, Public (Editors). Toward A Less Harmful Health Service, National Cancer Cigarette. U.S. Department of Institute Monograph No. 28, Jun Health, Education, and Welfare, Pub'tc 1968, pp. 237-48. Health Service, National Cancer Institute Monograph No. 28, Jun 1968, p. 211. A 10238 Tiggelbeck, D. COMMENTS ON SELECTIVE CIGARETTE- A 10233 SMOKE FILTRATION. In: Wynder, E. L. Tso, T. C. and Hoffmann, D. (Editorsi. Toward A EXAMINATION OF APLATOXIN IN TOBACCO Less Harmful Cigarette. U.S. Depart- AND IN CIGARETTE SMOKE. In: ment of Health, Education, and Welfare, Wynder, E. L. and Hoffmann, D. Public Health Service, National Cancer (Editors).Toward A Less Harmful Institute Monograph No. 28, Jun 1968, Cigarette. U.S. Departmekt of pp. 249-58. Health, Education, and Welfare, Public Health Service, National Cancer Institute Monograph No. 28, Jun 1968, A 10239 P. 213. Homburger, F., Trager, A., and Boger, E. EXPERIMENTAL STUDIES ON THE A 10234 INHIBITION OF CARCINCOENESIS BY Grob, K. CIGARETTE-SMOKE CONDENSATES AND GASEOUS COMPONENTS OF TOBACCO SMOKE. CARCINOGEN-RELATED SUBSTANCES. Ins Wynder, E. L. and Hoffmann, D. Ins Wynder, E. L. and Hoffmann, D. (Editors).Toward A Less Harmful (Editors). Toward A Less Harmful

9 A 10239 (continued) A 10281 Cigarette. U.S. Department of Rowlands, J. R., Eltefan, R. M., Gauss, Health, Education, and Well'are, E. M., and Montalvo, D. A. Public Health Service, Natf.onal AN ELECTRON SPIN RESONANCE STUDY OF Cancer Institute Monograph No. 28, TOBACCO SMOKE CONDENSATES AND THEIR Jun 1968, pp. 259-70. EFFECTS UPON BLOOD CONSTITUENTS. Environmental Research 2(1)147-71, Sep A 10245 Swann, P. F. and Magee, P. N. NITROSAZ4INE- INDUCED CARCINCOENESIS. A 10292 THE ALKYLATION OF NUCLEIC ACIDS OF Frasca, J. M., Auerbach, 0., Parks, THE RAT BY N -METHYL -N-NITRCSOUREA, V. R., and Jamieson, J. D. DImTTHYLNITROSAMINE,DIMETHYL ELECTRON MICROSCOPIC OBSERVATIONS OF SULPHATE AND METHYL METHANESULPHONATE. THE BRONCHIAL EPITHELIUM OF DOGS. Biochemical Journal 110:39-47, 1968. II. SMOKING DOGS. Experimental and Molecular Pathology. 9(3)1380-99, SWF T968. A 10251 Reuber, M. D. and Lee, C. W. EFFECT OF AGE AND SEX ON HEPATIC LESIONS A 10303 IN BUFFALO STRAIN RATS INGE3TING Van Duuren, B. DIETHYINITROSAMINE.Journal of the TOBACCO CARCINOGENESIS. Cancer Research National Cancer InstitUrirfC(T:TI73 -40, 28(11)12357-62, Nov 1968. Nov 1968.

A 10310 A 10254 Akaike, S. and Yamada, S. Kaneko, H. and Ijichi, K. TABAKO SHOKUBUTSU SEIBUN NI KANSURU THE AROMA OF CIGAR TOBACCO. PART I. KENKYU. V. KURCROOENSAN TEIRYOHO NO ISOLATION OF 2 -HYDROXY-2,6,6 - KAIRYO. (STUDIES ON THE CHEMICAL TRINSTHYLCYCLOHEXYLIDENE -1 -topic ACID CONSTITUENTS OF TOBACCO PLANT. V. LACTONE {DIHYDROACTINIDIOLIIE) FROM IMPROVEMENT OF CHLORCOENIC ACID DETERMINA- ETHER EXTRACT OF CIGAR LEAVES. TION.) HatanTabako Shikenjo Hokoku Wicultural and Biological Chemistry (57)15-1 , Dec TIM; Japanese (Abs.) 32(11)11337-40, Nov 1968. A method fcr the extraction and determination of chlorogeric acid in A 10255 fresh and cured tobacco leaves is Hebert, D. W. and Oelboin, H. V. described. SUBSTRATE-INDUCIBLE 141CROSOMAL ARYL HYDROXYLASE IN MAMMALIAN CELL CULTURE. I. ASSAY AND PROPERTIES OF INDUCED A 10311 ENZYME. Journal of Biological Chemistry, Akaike, S., and Yamada, S. 243(23116242-9, Dec 10, 1-966. TABAKO SHOKUBUTSU SEIBUN NI KANSURU KENKYU.VI. KAFESAN, SUKOPORECHIN, RUCHIN NO TEIRYOHO. (STUDIES ON THE A 10259 CHEMICAL CONSTITUENTS OP TOBACCO PLANT. Engelberg, H. and Engelberg, L. P. VI. DETERMINATION OF CAFFEIC ACID, TriE EFFECT OF CIGARETTE SMOKING ON SCOPOLETIN AND RUTIN.) Hatano Tabakp VARIOUS CLOTTING TIME TESTS. Vascular Shiken'o Hokokm (57)116-n76;c 1966, Diseases 5(4)1226-30, Dec 19G8. apanese 1157.7

Methods for the separation and deter- A 10260 mination of caffeic acid, ecopoletin, Hanninen, O. and Attic), A. and rutin in fresh and cured tobacco ENHANCED OLUCURONIDE FOP.MATION IN DIFFER- leaves are described. ENT TISSUES FOLLOWING LRUG ADMINISTRA- TION. Biochemical Pharmacolcia 17(11)1 2307-11, Nov 1968. A 10312 Akaike, S. and Yamada, S. TABAKO SHOKUBUTSU SEIBUN NI KANSURU A 10269 KENKYU. VII. TABAKO NO SEIIKU NI Annals of Internal Medicine. TOMONAU PORIFENCRU SEIBUN GANRYO NO ALCOHOL, OTHER DRUGS, AND THE LIVER. MENU. (STUDIES ON THE CHEMICAL Annals of Interne, Medicine 69(5)11063-7, CONSTITUENTS OF TOBACCO PLANT. VII. Nov T368: CHANGES IN POLYPHENOL :ONTENT OF BRIGHT

10 A 10312 (continued) A 10325 (continued) TOBACCO LEAVES DURINO GROWTH AND OF TOBACCO LEAF.'i Hatano Tabako MATURATION.) Hatano Tabako Shikenjo Shiken .lo Hokoku 57):514-66, Dec 1966, Hokoku (57)1277177Dec 1966, Japanese Japanese Tra:r (Abs.) To determine the route of biosynthesis Results are given of determinations of chlorogenic acid in tobacco leaves and of chlorogenic acid, caffeic acid, the various intermediates, disks of rutin, scopoletin, and nicotine in tobacco leaf (var. Bright Yellow) were tobacco leaves at different stages of floated on aqueous solutions of various growth and maturation.Nicotine content compounds and the net synthesis of increased sharply to its highest level chlorogenic acid during incubation was after topping. determined. The compounds used as culture media were 1-Phenylalanine; quinic acid; glucose; trans-cinnamic acid; A 10513 shikimic acid; 1-tyrosine; 1-tryptophane; Akaike, S., and Yamada, S. dl-DOPA; phenylpyruoic acid; and ferulic TABAKO SHOKUBUTSU SEIBUN NI KANSURU acid. KENKYU. VIII. TEKISHIN OYOBI KAMEN TABAKO SHOKUBUTSU NO HACHU PCRIFENORU SEIBUN OANRYO. (STUDIES ON THE CHEMICAL A 10323 CONSTITUENTS OF TOBACCO PLANT. VIII. Saindelle, A., Ruff, F., (Willem, R., and CONTENT OF POLYPHENOIS IN LEAVES OF Parrot, J.-L. TOPPED AND INTACT TOBACCO PLANTS. LIBERATION D'HISTAMINE PAR LA FUMEE DE RatanTabako Shikenjo Hokoku(571:42-6, CIGARETTE ET CERTAINS DE SES CONSTITUANTS. Dec 96T77ipanese (Abs.) (LIBERATION OF HISTAMINE BY CIOARETTE SMOKE AND CERTAIN OF ITS CONSTITUENTS.) Results are given of measurements of Revue Francaise D'Allergie 6(3):137-44, chlorogenic acid, rutin, total nitrogen, AirlerInc-Prench(Abs.) and protein nitrogen in the upper and middle leaves of intact and topped Water-soluble gas phase of cigarette tobacco plants (var. Bright Yellow). smoke, in the absence of all sensitivity, was capable of liberating histamine from the isolated lung of guinea pigs. This A 10314 property was attributed, not to nicotine, Akaike, S., and Yamada, S. but to ethanol. Acrolein was not capable TABAKO SHOKUBUTSU SEIBUN NI KANSURU of liberating important quantities of KENKYU. IX. TEKKAN KANSO HATABAKO NO histamine from guinea pig lung. KUROROCIENSAN OYOBI RUCHIN OANRYO TO HINSHITSU TOKYU TO NO KANKEI, NARABI NI OANRYO NO SANCHI NI YCRU HENDO. (STUDIES A 10325 ON THE CHEMICAL CONSTITUENTS OF TOBACCO Schmiterlow, C. O. PLANT. IX. CONTEVIS OF OHLOROGENIC ACID MITT FORSKNINGSFALT-NIKOIINETS DISTRIBU- AND RUTIN IN FLUE-CURED TOBACCO, THEIR TION OCH METABOLISM I DEN LEVANDE RELATION TO QUALITYAND CONTENT VARIA- OROANISMEN. (MY FIELD OF RESEARCH- TION WITH LOCALFri.1 Hatano Tabako DISTRIBUTION AND METABOLISM OF NICOTINE Shikenlo Hokoku (57 14337;-6R) 166, IN THE LIVING ORGANISM.) Nordisk Japanese (Abs.) Medicin 60(43)11436-40, Oct 28, 1968, gWeaTEK (Abs.) In the case of both Bright yellow and Hicks tobacco, it is shown that there is Our studies with radioactively a positive correlation between quality labelled nicotine, made by the autoradi0- grades and the content of chlorogenic acid graphic technique devised by Ullberg, and and rutin.Chlorogenic acid and rutin chromatographic methods, have shown that contents were also found to vary with nicotine and/or its metabolites accumulete locality. in certain target organs, primarily the brain, adrenal medulla, autonomus ganglia, and the stomach. There are also other A 10315 target organs, for instance the retina and Akaike, S., and Yamada, S. the walla of blood vessels. Nicotine and TABAKO SHOKUBUTSU SEIBUN NI KANSURU its metabolites also accumulate in kidney KENKYU. X. ENKEI HA SEPPEN NO and liver. Nicotine passes easily tnrough KUROROOENSAN SEIGOSEI NI OYCSOSU KAKUSHU the placenta, thus being transferred to the KAGOBUTSU NO EIKYO. (STUDIES ON THE foetus, where it is distributed in the same CHEMICAL CONSTITUENTS OF TOBACCO PLANT way as in the mother. A particularay X. EFFECT OF VARIOUS COMPOUNDS ON THE interesting observation seems to us to be BIOSYNTHESIS OF CHLGROGENIC ACID IN DISKS that the nicotine concentration in the A 103%5 (continued) A 10335 brain decreases very quickly and that Dav, T. L. initially nicotine accumulates in the STUDIES ON MECHANISM OF CARCINOOENESIS grey matter and certain nuclei of the IN THE MAMMARY OLAND. in: Homburger, brain, for instance in the hippocanpus. Y. (Editor). Progress in Experimental We hays studied the breakdown of nicotine Tumor Research Vol. 2: International in the body and thus been able to verify Symposium on Carcinogenesis and earlier authors' observations that Carcinogen. Testing. Boston, Mass, cotinine is the primary metabolite. As Nov 8-9, 1967, Basel, Switzerland/ regards other metabolites, we have New York, S. Karger, 1969, pp. 256-61. identified threes a few we have not yet been able to identify with certainty. (Author Abstract) A 10338 Safflotti, U. EIPERIMENTAL RESPIRATCHY TRACT CARCINO- A 10331 GENESIS. In: Homburger, F. (Editor). Taira, N., Nakayama, X., Sano, N., and Progress in Experimental Tumor Research Hashimoto, K. Vol. 2, International Symposium on NICOTINIC PROPERTY OF ACETYLCHOLINE Carcinogeneela and Carcinogen Testing. RECEPTORS SUBSERViND :;OCICEPTION IN THE Boston, Mass., Nov 8-9, 1967.Basel, PUPPY HINDLIMB AS REVEALED BY THE Switzerland/New York, S. Karger, 1969, ACTIVITY OF CHOIINEROIC AOONISTS pp. 302-33. ADMINISTERn INTO THE FEMORAL ARTERY. Tohoku Joul.Na' of Experimental Medicine 96(1):11172, -oep 1965: A 10337 Porta, O. D. and Terracini, B. CHEMICAL CARCINOOENESIS IN INFANT A10332 ANIMALS. In, Homburger, F. (Editor). Shimkin, M. B. and Triolo, V. A. Progress in Experimental Tumor Research HISTORY OF CHEMICAL CARCINOOENESIS: Vol. 2s International Symposium on SOME PROSPECTIVE REMARKS. In Carcinogenesia and Carcinogen Testing. Homburger, F. (Editor). Progress in Boston, Mass., Nov 8-9, 1967.Basel, Experimental Tumor Research Vol. 21 Switzerland/New York, S. Karger, 1969, International Symposium on Carcino- pp. 334-63. genesis and Carcinogen Testing. Boaton, Maas., Nov 8-9, 1967. Basel, Switzerland/New York, S. Karger, A 10338 1969, PP. 1-20. Diamond, L. THE INTERACTION OF CHEMICAL CARCINOGENS AND CELLS IN VITRO. Inc Homburger, F. A 10333 (Editor). Tiogreas in Experimental Van Duuren, B. L. Tumor Research Vol. 2i international TUMOR-PROMOTINO AGENTS IN TWO-STAGE Symposium on Caroinogenesis and Carcinogen CARCINOGENESIS. In Homburger, F. esting.Boston, Mass., Nov 8-9, 1967. (Editor). Progress in Experimental Basel, Switzerland/New York, S. Karger, Tumor Research Vol. 2, International 1969, pp. 364-83. Symposium on Carcinogeneale and Carcinogen Testing. Boston, Mass., Nov 8-9, 1967. Basel, Switzerland/ A 10339 New York, S. Karger, 1969, pp. 31-68. Burdette, W. J. CAUSALITY, CASUISTRY AND CLINICAL CARCINOOENESIS. Ins Homburger, F. A 10354 (Editor). Progress in Experimental Boyland, E. Tumor Research Vol. 2; international THE CORRELATION OF EXPERIMENTAL Symposium on Caroinogenesis and Carcinogen CARCINOGENESIS AND CANCER IN MAN. Testing. Boston, Masa., Nov 8-9, 1967. Inc Homburger, F. (Editor). Progress Basel, Switzerland/New York, S. Urger, in Experimental Tumor Research Vol. 1969, PP. 395-450. 2, International Symposium on Carcinogenesis and Carcinogen Testing. Boston, Mass., Nov 8-9, 1967. Basel, A 10350 Switzerland/New York, S. Karger, Zielke, H. R., Reinke, C. M., and 1969, pp. 222-34. Byerrum, R. U. INCCRPORATION OF CARBON DIOXIDE AND ACETATE INTO THE PYRIDINE NINO OP NICCTINE. jolIfnal 2f 114211Ltell Chemistry 244 )195=3,-Tar-1-10,-1969.

a A 10352 A 10364 Van Duuren, B. L. and Sivak, A. Campbell, H. E. CARBON MONOXIDE, SMOKING IN AUTOMOBILES, TUMOR - PROMOTING AGENTS FROM CR Journal of TIOLIUM J. AND THEIR MODE ON. AND IN HAYLOFTS. (Letter) NH-Cir.Research 28(11):2349 -56, Nov 1968. the American Medical AssociaT1705g5); ,Feb 5, 11117---

A 10353 Hoffmann, D., Maauda, Y., and Wynder, E. L. A 10366 ALPHA-NAPHTHYLAMINE AND BETA-NAPHTHYLAMINE Shklsr, O. THE E ECT OF MANIPULATION AND INCISION IN CIGARETTE SMOKE.Nature 221(5177): n4-6, Jan 18, 1969. ON EX.eRIMENTAL CARCINOMA OF HAMSTER BUCCAL POUCH. Cancer Research 28(11): 2180-2, Nov 196L A 1054 Yoshida, T. 0., Imai, K., and Sugiyama, T. A 10367 AUTO-ANTIBODY TO 7,12-DIMETHYLBEN2(a)- Harvey, R. G. and Halonen, M. ANTHRACENE-INDUCED LEUKEMIC CELLS IF INTERACTION BETWEEN CARCINOGENIC Cancer RATS AS DETECTED BY IMMUNE ADHERENCE. HYDROCARBONS AND NUCLEOSIDES. International Journal of Cancer 3(6): Research 28(10:2185-6, Nov 1965.----- nt-6,NOv 15, 1968. A 10372 Bates, W. W., Griffith, R. B., Harlow, A 10355 Diamond, L., Sardet, C., and Rothblat, E. S., Senkus, M., and Wakeham, H. DETERMINATION AND REPORTING OF TOTAL G. H. PARTICULATE MATTER, WATER IN TOTAL THE METABOLISM OF 7,12-DIMETHYLBENZ(a)- PARTICULATE MATTER, AND NICOTINE IN ANIHRACENE IN CELL CULTURES. International Journal of Cancer 3(6): CIGARETTE SMOKE. Virgiiria Journal 338:417M15717g137 of Science 18(4)11 , 6S.---

A 10358 A 10373 Pound, A. W. Oebber, O. L. CAROINOGENESIS AND CELL PROLIFERATION. DISSOCIATION OF DEPOLARIZATION AND GANGLIONIC BLOCKADE INDUCED BY New Zealand Medical Journal 67(426, Journal of Pharmacology SpecnIT-TiTuira=1.97-3FRT968. NICOTINE. and ExyerimFEETTherapeutIca 160(1): T2T-34, 1968. A 10359 Oelboin, H. V. CARCINOSENESIS AND GENE ACTION.Franz A 10374 Bielschowsky Memorial Lecture.New Oardier, R. W., Abreu, B. E., Richards, Zealop.4 Medical Journal 67(426, A. B. and Herrlich, H. C. nicial SPECIFIC BLOCKADE OF THE ADRENAL rimil1110-27, arm. MEDULLA. Journal of Pharmacology and Ex erliWail-Wirapautics 130: A 10362 TM- , Nov Maki, Y., Kanda, M., Yoshida, H., Ishida, A., and Tanaka, S. EFFECr OF ANTINEOPLASTIC AGENTS ON A 10376 INDUCTION OF MICROSOMAL DRUG Sheen, S. J. and Calvert, J. QUANTITATIVE VARIATION IN POLYPVENOL METABOLIZING EHMAN12 AND AIR-CURED MedicalJournaEMJ:129-3*, -Sep 30, CONTENT IN THE OR LEAVES OF TCBACCO NICOTIANA TABACUM L.) Tobacco 168(3)) :24-6, Jan 17, 1989.

A 10363 Daleesic, D. J. A 10377 AND THE ANTIDIURETIC HORMONE. Welch, R. M., Harrison, Y. E., Clonal, NICCM1NE B. W., Poppers, P. J., Finater, M., (tter) Journal 2f A Medical ALsseociation 207(g):151the 76mericanV371T6/7----- and Conney, A. H. STIMULATCAY EFFECT OF CIGARETTE SMOKING ON THE HYDROXYLATION OF 3,4-BENZPYRENE AND THE N-DEFITHYLATION OP 3-METHYL-

9 A 10377 (continued) A 10399 4-MONOMETHYLAMIN0A2M,NZENE BY Vesselinovitch, S. D. and Mihailovich, N. ENZYMES IN HUMAN PLACENTA. Clinical THE INHIBITORY EFFECT OF ORISEOFULVIN Pharmacology and lzirtramIticsT 10(IT: ON THE "PROMOTION' OF SKIN 100-9, Jgh=FerT9 . CARCINOGENESIS.Cancer Research 28(12):2463 -5, Dec 1966. A 10378 Domino, E. F. and von Baumgarten, A. M. A 10408 TOBACCO CIGARETTE SMOKING AND PATELLAR Chamberlain, W. J. and Stedman, R. L. REFLEX DEPRESSION.Clinical COMPOSITION STUDIES ON TOBACCO-- nrm A-ELA_ogyand ThelipfiEs 10(1)1 XXVIII. 2,3,6-TRIMEIHYL-1,4- 72=97an-nbr69. NAPHTHOQUINONE IN CIGARETTE SMOKE. Phytochemistry 7:1201-3, 1968. A 10384 Albanese, A. A. A 10411 INTERIM PROGRESS REPORT ON THE EFFECTS Yamagata, S. and Ishimori, A. OF SMOKING ON THE BIOCHEMISTRY OF OAI INSEI YOIN NI YORU MANSEI IEN. PHYSICAL ACTIVITY. The Burke (THE PRINCIPAL EXTRINSIC FACTORS Re,,bilitation Center, Nutrition and CONTRIBUTING TO CHRONIC GASTRITIS.) Metabolic Research Division, White Saishin Igaku 23(10)82015-22, Oct Plains, N. Y., Oct 28, 1966, 2 pp. 1968, Japanese (Abs.)

In a review of the literature on A 10386 the etiology of chronic gastritis, Carlson, O. M., Ruddon, R. W., Bass, P. reference is made to tha per by INHIBITORY EFFECT OF NICOTINE UPON Edwards and Coghill (1966) on the UPPER GASTROINTESTINAL CONTRACTILE relation between smoking and the ,ACTIVITY IN THE DOG. Paper presented development of gastritis. It is also at EASES Annual Meeting, Atlantic speculated that the carcinogen N,W- City, N. J., Apr 18, 1968, 11 PP. 2,7-fluorenylenebisacetamide, which has been shown to be a constituent of tobacco and is soluble in saliva, may A 10392 directly effect the gastric mucosa. del Castillo, J., Rodriguez, A., and Romero, C. A. PHARMACOLOGICAL STUDIES ON AN A 10417 ARTIFICIAL TRANSMITTER- RECEPTOR Shintani, K. SYSTEM. Afinals gE the New York SANSO OYOBI CO OASU BAKURO NO Academy pl clences-a4g)a53718, HATSUOAN NI OYOBOSU EIKYO. (EFFECT 107. OF OXYGEN OR CO OAS EXPOSURE ON CARCINOOENESIS.) Nagoya-Shiritsu Daigaku Igalskei Zaashi-19(2)1185-524, A 10396 Aug 1968-3IPTineiiTrEs.) Sugiura, K. CHEMOTHERAPY OF INDUCED SKIN TUMORS The known carcinogen, 3-methyl- IN MICE.Cann 59(5)8367-76, Oct 1968. 4-dimethylaminoatobenzene, was fed to rats in a normal atmosphere, and in atmospheres of oxygen and carbon A 1039? monoxide. The effect of oxygen and Frei, J. V. and Kingsley, W. F. carbon monoxide on the rate of OBSERVATIONS ON CHEMICALLY INDUCED tumor development and on the numbers REORESSINO TUMORS OF MOUSE EPIDERMIS. of red and white blood cello was /puma' at alicgal Cancer determined. Tnetitute 411-1-6)4I307=1377GT-Dec

A 10423 Oardier, R. W., James, B. A., Jr., A 10398 Johnson, P. C., Richards, A. B., and Takayama, S. and Inui, N. Roesch, R. P. ACCELERATION OF LIVER CELL PROLIF- VASODEPRESSION INDUCED BY ACETYL- ERATION IN' MN BY /- CHOLINE IN THE ATROPINIZED DOO. NITROSODIWTTLAMINE. Gann 59(5): British iournal of Pqamacology and 437-9, Oct 1968. ChemotheraPY 268579-85, 1 63.

14 A 10428 Harris, R. J. C. A 10442 Wattenberg, L. W., Page, M. A., and CARCINOOTNICITY OP CIGARETTE SMOKE. Leong, J. L. Practitioner 201(1206)8964, Dec 1668. INDUCTION OF INCREASED BENLPYPENE NYDROXYLASE ACTIVITY BY 2-PHENYL- BENZOTHIAZOLES AND RELATED Ctt1POUNDS. A 10429 Cane Research 28(12)82559-44, ec Daniel, E. E. and Marks, O. S. PRESSOR RESPONSE TO ACETYLCHOLINE AND THE EFFECTS OF N-DZETHYLAMINCETHYL- A 10445 N-ISOPENTYL-N)N-DI-ISOPROPYLUREA. Harvey, W. R., Stehr, H. M., and British Journal of Pharmacology and Smith, N. C. Chemotherapy 248Z19-54, 1965. AUTOMATED DETERMINATION OF REDUCING SUGARS AND NICOTINE AIXALOIDS ON THE A 10454 SAME EXTRACT OF TOBACCO LEAF. Kroger, H., Kahle, P., and Keseel, H. Tobacco 168(4)148-50, Jan 24, 1969. -1,1/9-METHYLIERUNG VON RATTENLESER- -UNTER EINFLUSS V DIATHYINITROSAMIN. ;Vag A 10447 Bell, J. A., Sneddon, A., and Hamilton, KETHYLATION OF RAT L -RITX AND T. THE EFFECT OF DIETNYLNITROSANINE.) Hotloa-Ssylerls Zeitechrift INFLUCE OF IGHTAND9,10-DIHYL-MET Burs121sgische ehesie 549(12)11725-32, BENZ(aEN)ANTHRALCENEON RAT OVARIAN DOO 1,68, German (Abe.) STERIBDCOENESIS:NEUTRAL STERIODS Biochagical Journal 110(3)829P-50P, MA 1988. Studies are reported on the in vii m methylation of rat liver R. RNX-Was fractionated from rat liver A 10454 at varying time intervals afterthe injection of (methyl-SH)L-methionime. Monteasno, R. and Saffiotti, U. It was shown that transfer RNA is CARCINOGENIC RESPONSE OF THE RESPIRA- TORY TRACT OF SYRIAN GOLDEN HAMSTERS methylated in the cytoplasm (or TO nuclear sap), while the ribosomal DIFFERENT DOSES OF DIETHYLMITRO- RNA arises from a methylated 45 S SAMINE. Cam r Beaeardh 28(11)8 2197-210, Nov 1968. Precursor in the nucleus. After feeding the carcinogenic diethylnitrossmine for 30 days, A 10455 the incorporation of (6-1460- Hecker, B. orotic acid into RNA and the methylation of ribosomal RNA are CoOARCINCOENIC PRINCIPLES FROM THE decreased but the methylation of SEED OIL OP CROTON TIOLIUN AND FRCM transfer RNA is not affected. OTHER EDPHORBIACEAE. Cancer Retouch (Author Abstract) 28(11)82338-48, Nov 1968.

A 10436 A 10464 Oinzel, K. H. Carlton, W. W. and Weiser, J. R. ACTION OP NICOTINE ON ourcaamic OLONERULAR LESIONS INDUCED IN PEKIN DUCKS BY DIETARY ADMINISTRATION OF AND SOMATIC REFLEXES. e di Qt Valtalacia DIMETHYLN/TROSAMINE. Toxicology an A aakti ghvauslase 13(S)1 0-0Y WM' 404-11,-Nov Alma.

A 10441 A 10469 Stubman, 0., Yunie, E. J., and Good, R. A. Zillfyan, V. N., Pichidthyan, B. S., A. CARCINOGEN-INDUCED Tumcas OP THE liCwolastadthyan, V. THYMUS.1.RESTORATION LOP itvoulai ICIMO3OE Y Jc04,40Cce cordemtve*W.ii kW. NEONATALLY THYNECTOMUED MICE WITH A FUNCTICHAI THYMOMA. INDUKTSIYA LEYKOZOV U XIICMYACHKOV gt 141 Nici,Ang cancer ut 41(1=6)T1(5142, Jul-Dec SXARMLIVANIYEM MBA. (INDUCTION OP IEUKOSES IN HAMSTERS Al:MINIS/1M DMBA.) Zh 1 ic Utalreatiii-5, r9 . sa an ( a. A 10469 (continued) A 10488 Bock, F. 0., Fielde, A., Fox, H. W., Syrian hamstera (Cricetulus and Klein, E. microtorius Pall), administered TUMOR PROMOTION BY 1-FLUOR0-2,4- 1,235,8-010enzenthracene per os, DINITROBENZENE, A POTENT SKIN failed to develop leukoses. It was SENSITIZER. Cancer Research 29(1)1 assumed that this blastomogen 179-82, Jan 007-- possesses no leukogenic properties in these animals. Per oa administration of the blastomogen 9,10-dImethy1-1,2- A 10489 benzanthracens reeulted in the develop- Goldenberg, M. M. ment of leukoses of the hemocytoblastoma ANALYSIS OF THE IM4IBIT3RY INNERVA- typt in one-third of the cases in the TION OF THE ISOLATED GERBIL COLON. cour s of 6 to 32 months. Archives Internationales de Ish-7"-ar co(laynamre et'de Therapie 175(2): 347-64, Oct 1988. A 10474 Guillerm, R., Badre, R., Saindelle, A., Hee, J., and Flavian, N. A 10490 ACQUISITIONS RECENTES Sp LA TOXICOLOGIE Gascon, A. L. and Walaszek, E. J. DE LA VUMEE DE TABAC. (RECENT EXPERIgNCE MECHANISM OF THE MUSCULOTROPIC WITH THE TOXICOLOGY OF TQBACCO SMOKE.) ACTIVITY OF ANOIOTENSIN ON THE Gazette des Hopitaux 140(3p):861-2, ISOLATED GUINEA -PIO SEMINAL VE:ICIE. an-sr; rin, French (Abs.) Archives Internationales de 7Egiiign4pamie et de Therapie 178(2): Recent experimental work 265-72, Oct 1988. demonstrates the toxic effects of the irritant products contained in tobacco smoke on the respiratory A 10492 tract and permits a better understanding Adachl, K., Yamasawa, S., and cf the etiology of respiratory disorders Montagne, W. in smokers. Cilia- inhibiting action of EPIDERMAL HYPERPLASIA INDUCED BY the smoke causes an arrest of drainage 7,12-DIMETHYLBENZ(a)ANTHRACENE IN of the bronchi and trachea and by this PROSIMIANS. Journal of Ihft National means favors the attack of the aerial Cancer Institute 42(1761=8, -713-21T9. tract by carcinogenic agents or infectiona as witness the Incidence of chronic bronchitis in smokers. A 10499 Acetaldehyde and acrolein appear to Oren, A. T. and Domino, E. F. be the principal constituents of the CHOLINERGIC AND AIRENERGIC ACTIVATING gas phase of the cigarette smoke AGENTS AS ANTAGONISTS OF THE EEO responsible for this inhibitory effect EFFECTS OF HEMICHOLINIUM-3. Archives but the particulate phase of the smoke Internationales de Pharmacodynamie o leo seems to play some part.The et de Therapie 11(1),63-72, Sep 1968. Identification of the smoke constituents responsible for these effecte permits the orientation of research towards the A 10521 selection of lees aggressive tobaccos Polyak, N. R. and the development of more selective filters. ommENI1196 npo PA3egn,m 3KCAP1+Em7Anbit0C OROWES.

A 10478 0 KANTSEROLIZE PRI RAZVITII Benedict, R. C. and Stedman, A. L. EKSPERIKENTALINYKH OPUKHOLEY. COMPLEXITY OP ENZYMATIC INHIBITION IN THE DEVELOPMNT OF E(CARCINOLYSISXPERIMENTAL TUMORS.)Voprosy BY CIIARETTE SMOKE. Experientia. 1 11 14(10)349-52, 1968, Russian 24(12)11205-6, 1968. s.

A 10487 The effects of transplanted tumors, Brookes, P. and Heidelberger, C. intravenous Injection of 9,10-dimethyl- ISOLATION AND DEGRADATION OF ENA benz(a)anthracenes, and Irradiation FROM CELLS TREATED WITH TRITIUM- with Fart neutrons resulting in LABELED 7,12-DIMETHYLBENZ(a)ANTHRACENE1 tumors were investigated in white rats. All reduced the lytic properties of the STUDIES CV THE NATURE OF TRg BINDING OP THIS CARCINOGEN TO DNA. blood serum long before the appearance Cancer of tumors. The develorent of tumora Research 29(1)3157-65, Jan 1969.

16 A 10521 (continued) A 10544 resulted in even greater inhibitory Salndelle, A., Ruff, F., Flavian, N., action on the carcinolytic properties and Parrot, J.-L. of the blood serum. LIBERATION D'HISTAMINE PAR DES ALDEHYDES A COURTE CHAINE. (LIBERA- TION OF HISTAMINE BY SHORT-CHAIN A 10522 ALDEHYDES.) Comptes Rendus Schutte, H. R., Maier, W., and Stephan, Hebdomadaires des Seances 1'Academie U. es tefences P77157-757Fres 6-f777- ZUR BIOSYNTHESE DES NICOTINS. 131-117-7ii-8, 1968, French (Abs. (BIOSYNTHESIS OF NICOTINE.) Zeitschrift fur Naturforschung 23(11): Acetaldehyde, which is present in 4426-9, Nov TM, German (Abs.) the as Phase of cigarette smoke, was the only aldehyde capable of liberating Application of N-methylputrescine notable quantities of histamine from (1-14-C, 15-N-CH3) and of N-methyl- isolated guinea-pig lung. These putrescine (1-T) to nicotiana quantities were comparable to those rustics results in as1.711TE liberated by the total water-soluble 177356ration of the radioactivity constituents of the smoke. Acrolein in the 5' position of the pyrrolidine and formaldehyde were capable of ring. The results indicate that liberating lesser quantities of N-methylputrescine is incorporated histamine but propionaldehyde was asymetrically into nicotine and that completely inactive under the condi- a methylation prior to pyrrolidine tions of the experiment. ring closure ie possible.

A 10545 A 10527 Arnold, O. Krewson, C. F. and Chortyk, O. T. L'ACTION PHARMACOLOGIQDE DE LA COMPARATIVE STUDIES ON TOBACCO LEAF. NICOTINE. (PHARMACOLOGICAL Use of a Rapid Extraction Technique. ACTION OF NICOTINE.)Madeoine el AmeriCan Journal of pharmacy 140(2): Mygiene 26(840):1085, Oct 1968, 44-51, MiF=XTF-T954. French (Abs.) Experiments on rats indicated that A 10531 4 micrograms/kg of nicotine injected Arundell, F. D., Karasek, M. A., and every 60 seconds had a lower stimulant Gates, A, H. effect than 2 micrograms/kg every 30 7,12-DIMETHYLBENZANTHRACENE TUMOR seconds. When the injections were INDUCTION IN MUTANT (HAIRLESS, ASEBICI made more frequently, 1 microgram/kg AND HAIRLESS-ASEBIC) MICE. Journal of every 15 seconds, the action was Inverti ative Dermatology 52(2f:11945, stimulant in some animals and Ie b 1969. depressant in others. injections of F. micrograms/kg of nicotine every 30 seconds for 20 minutes (40 injections) A 10552 in anesthetized cats resulted in Kay, K. sharp changes in the encephalogram in PESTICIDES AND ASSOCIATED HEALTH 7 out of 10 animals.Less frequent FACTORS IN AGRICULTURAL ENVIRON- but stronger doses, 4 micrograms/kg MENTS. industrial Medicine and every minute for 20 minutes generally Surgery 18(1):501W-711711637- produced the same results. In 2 out of 6 cases the liberation of acetylcholine was reduced and the A 10554 encephalogram indicated a reduced Homburger, F. activity. It was estimated that 2 CHEMICAL CARCINO0 IS IN THE SYRIAN micrograms/kg administered every 50 GOLDEN HAMSTER. A Review) Cancer seconds for PO minutes approximates 23(2)1513-58, Feb 1969. the quantity of nicotine absorbed by a smoker Who inhales deeply the smoke of 2 cigarettes. The Increase in A /0545 cortical activity, analogous to that Sunas, E. C., Williams, J. F., and induced by the intravenous injection Kidd, D. H. of nicotine in cats, could explain the RAPID DETERMINATION OF CITRATE IN subjective impression of a greater CIGARETTE PAPERS.Tobacco 168(8)t30, Feb capacity of concentration and of greater 21, 1969. efficiency.

13 A 10547 A 10553 Hazard, R. and Rodallec, A. Allt, W. R., Pilkington, T. R. E., MODIFICATIONS APPORTEES COMPARATIVE- and Woolf, N. RENT PAR LIEROOTAMINE ET PAR NICOTINE HYDROGEN TARTRATE; EFFECT L'YOHIMBINE A L'ACTION TENSIONNELLE ON ESSENTIAL FATTY ACID DEFICIENCY DE LA NICOTINE CHEZ LE LAPIN. IN MATURE PIGS. Science 163(3865)1 (COMPARATIVE CHANGES CAUSED BY 391, Jan 24, 1969. ERGOTARINE AND YOHIMBINE ON THE PRESSOR ACTION OF NICOTINE IN RABBITS.) Comptes Rendus des Seances de la A 10556 Societe TrffiFfOliri-FE7Tises 7711ales Kojima, M. and Takagi, H. 162(4):8U4, Nov 23, irg8771gifer EFFECTS OF SOME ANTICHOLINERGIC (Abs.) DRUGS ON ANTIDROMIC ACTIVITY IN THE RAT PHRENIC NERVE-DIAPHRAGM PREPARA- Ergotamine and yohimbine modify TION. Euro can J urnal of Pharmacology differently the pressor effect 5(2):16 - , an exercised by nicotine. The first favors the strengthening of the hypertensive phase and weakening of A 10558 the hypotensive phase while the Armitage, A. K., Hall, O. H., and second more often suppresses the Sellers, C. M. nicotinic hypertension while exagger- EFFECTS OF NICOTINE ON ELECTROCORTICAL ating the hypotensive phase. ACTIVITY AND ACETYLCHOLINE RELEASE FROM THE CAT CEREBRAL CCRTEX.British Journal of Pharmacology 35(1)012-60, A 10550 10-170. Galy, P. and Perrin, L.-F. LE SURFACTANT ALVEOLAIRE DANS LE POUMON NORMAL ET PATHOLOGIQUE. A 10561 (ALVEoLAR SURFACTANT IN THE Thompson, J. H., Spezia, C. A., and NORMAL AND PATHOLOOICAL LUNG.) Angulo, M. Revu Iyonnaise de Medecine 17(15): THE RELEASE OF INTESTINAL SEROTONIN 677-84, , n58, Fran& (Abs.) IN RATS BY NICOTINE. urnal of the American Medical Assoc aon 237(T67i A tensio-active substance or IRAP5=5;-Mar-IUT1969. surfactant is secreted by certain cells of the alveolar lining.The function of this substance is to A 10567 lower the surface tension to the Yasuhira, K. level of the alveoli when the EXPERIMENTAL INDUCTION OF LUNG alveolar surface diminishes. The CANCER IN RAT AND MOUSE WITH 03- absence or the inhibition of this NETHYLCHOLANTHRENE IN FREUND'S surfactant thus involves a ADJUVANT. Acta Pathologica reduction of the alveolar stability Japonica 17TTIT475-93, 1967. which can approach atelectasis. This substance appears late in the course of fetal development, A 10572 toward the sixth month of intrauterine Epstein, S. S., Mantel, N., and life in the human species. In the Stanley, T. W. premature neonate, the absence of PHOTODYNAMIC ASSAY OF NEUTPAL surfactant is responsible for SUBTRACTIONS OF ORGANIC EXTRACTS OF syndromes of fatal respiratory PARTICULATE ATMOSPHERIC POLLUTANTS. distress; on autopsy, the study of Environmental SScieenncee & Technology

the lungs of these infants, deceased 2f132-8, Feb 1 . asa result of this syndrome, shows that they have a surface tension much higher than lungs of neonates A 10577 deceased from other ailments. In Trethowie, E. R. the adult, an inhibition of the EFFECT OF COMBUSTION TEMPERATURE ON surfactant la almost certainly EPITHELIAL DAMAGE BY TOBACCO SMOKE. responsible for atelectases observed Scientific Australian 5(1)19-16a, after prolonged respiration in pure una 968 oxygen and those appearing after extracorporal circulation with certain types of oxygenators. It la considered possible that an alteration of the surfactant favors the development of emphysema, particularly in smokers. 14

18 A 10680 A 20609 (continued) Environmental Health and Safety can be listed as follows: (1) The Research Associates. antinicotinic effect by far the clearest EVALUATION OF THE MERITS OF TREATMENT (70 percent reduction) sometimes OF CIGARETTE PAPER WITH AMMONIUM obtained with relatively weak doses SULTANATE.Environmental Health and (5-6 mg/kg); (2) antinoradrenalinic Safety Research Associates, New Rochelle, (50-60 percent) but with effects N. Y., Report to `he American Safety already reached by at least 10 mg/kg Equipment Corporation, May 27, '968, of prenylamines (3) antiadrenalinic 58 pp. action which is clearly the weakest, not corresponding to any law, the opposite of the noradrenolytic which A 10583 is progressive and increases with the Frankenhaeuser, M.Myrsten, A-L., dose of prenylamine. The maximum Waszak, Neri, A., and Post, B. antihypertensive activity appears to DOSAGE AND TIME EFFECTS OF CIGARETTE lie between 15 to 30 minutes after the SMOKING. PlychopharmIscologia.13(4): completion of the intravenous injection 311-9, 1968. of prenylamine.These properties are apparently a consequence of an alpha- lytic activity. A 10584 Weir, 3. M., Dubitzky, M., and Schwartz, J. L. A 10614 COUNSELOR STILE AND GROUP EFFECTIVENESS Holma, B. and Hellatrom, P-A. IN A SMOKING WITHDRAWAL STUDY. A CIGARETTE SMOKE DOSAGE APPARATUS American Journal of Psychotherapy FOR EXPLIIIRENTAL ANIMALS. Archives 23(1)sle6=117-71h-r9g9". of Environmental Health 18(3)s386-9, Wr 1959. A 10565 Wynder, E. L. and Hoffmann, D. A 10617 BIOASSAYS IN TOBACCO CAROINOGENESIS. Umans, R. S., Lesko, S. A., and Progress in Experimental Tumor Ts'n, P. O. P. Nesearen IT1163-931 1967.. CHEMICAL LINKAGE OF CARCINOGENIC 3,4-BEN2PYRENE TO DNA IN AQUEOUS SOLUTION INDUCED BY PEROXIDE AND A 10584 IODINE. Nature 221(5282)063-4, Frith, C. D. Feb 22, 1919. PERSONALITY, NICOTINE AND THE SALIVARY RESPONSE. Life Sciences 7(22, Part 2)s 1151-6, Nov757 A 10625 Machova, J. and Boska, D. L'ACTION DE GANGLIOSTIMULAKTS SUR LA A 10687 TRANSMISSION SYNAPTIQUE. (THE ACTION Patterson, J. M., Baedecker, M. L., CF GANGLIONIC STIMULANTS ON THE SYNAPTIC Musick, R., and Smith, W. T., Jr. TRANSMISSION.) Th ra le 22(0:1337-42, POSSIBLE ROLE OF MINE, LEUCIEE AND 1967, French (Abs. TRYPTOPHAN IN FORMATION OF TOBM`r,0 STAR., Tobacco 168(9)124-5, Feb 28, 1969. Nicotine, DMFP, acetylcholine, McN-A-543, AHR -602, isoprenaline, serotonin, angiotensin, histamine, and A 20609 bradyklnine produced a facilitation of Donnet, V., Duflot, J. O., Jacquin, transmission in the ganglia. Increasing Ps t, J., and de Santi, P. P. the dose resulted in a change in facilita- ACTION ANTI-HYPERTENSIVE DE LA MERYL- tion and an inhibition of transmission. AMINE: ETUDE CRITIQUE. (THE ANTI- Angiotensin, histamine, and bradykinine HYPERTENSIVE ACTION OF PRENYLANINE. differed from other substances by the CRITICAL STUDIES.) Coo tee Rendus fact that at 1 mg, the maximum dose des Seances de laSocTite di tested, in one part of the tests they FRZIMinir ti NaTTNITOT61(11)s Produced a weak inhibition of transmission k-es-3, MOVIT771111M-Tne.) and in the other part, facilitation. Serotinin at 1 mg dosage, resulted in Pronylaaine, in doge, possesses inhibition of transmission of 50 percent antihypertensive properties with of the MAXIMUM, although the threshold regard to the catecholamines dose of inhibitory action was 2.5 (adrenaline and no.-adrenaline) studied micrograms. The threshold dose of and nicotine. The order of activity facilitory action of isoprenaline was

19 A 10625 (continued) A 10638 the lowest of all the substances tested. Ruskin, J., Gebel, P. P., Hart, L. M., Studying the effect as a function of time Thompson, H. K., Jr., and McIntosh, H. D. demonstrated the essential differences in RETINAL VASCULAR RESPONSES TO NITRITES, the group of nicotinic substances. The NITRATES, AND CIGARETTE SMOKING. charcter oe response in the non-nicotinic Southern Medical Journal 62(3)0;23-8, substances was analogous.The tests were n7-730. conducted upon urethan-narcotized cats by stimulation of the preganglionic fibers of the upper cervical ganglia. A 10640 Polliack, A. and LevlJ, I. S. THE EFFECT OF TOPICAL VITAMIN A ON A 10629 PAPILLOMAS AND INTRAEPITHELIAL CARCINOMAS Wheatley, D. N. INDUCED IN HAMSTER CHEEK POUCHES WITH ENHANCEMENT AND INHIBITION OF THp 9,10-DIMETHYL-1,2-BENZANTHRACENE. INDUCTION BY 7,12-DIMETHYLEENZ(a)- Cancer Research 29(2):327-32, Feb 1966. ANTHRACENE OF MAMMARY TUMOURS fR FEMALE SPRAGUE -DAWLEY RATS. pritish Journal of Cancer 22(4):787 -97, Dec 19687---- A 10657 Goldenberg, M. M. EFFECT OP CHRONIC VAGAL DENERVATION ON A 10630 DRUG-INDUCED RESPONSES OP ISOLATED RABBIT Johnson, S. ILEUM. Life Sciences 7(23, Part I): EFFECT OF THYMECTOMY ON THE INDUCTION 1311-5, M-1711T17- OF SKIN TUMOURS BY DIBENZANTHRACENE, AND OF BREAST TUMOURS BY DINETHYLEENZ- ANTHRACENE, IN MICE OF THE IF STRAIN. A 10684 British Journal of Cancer 22(4)1755-61, Kahan, B. D., Holmes, E. C., Reisfeld, rec 19687-- R. A. and Morton, D. L. WATER SOLUBLE GUINEA PIO TRANSPLANTA- TION ANTIGEN FROM CARCINOGEN- INDUCED A 10631 SARCOMAS. Journal f Immunology Rusk, H. S. 102(1)128-36, Jan 1169. HEADACHE AND THE DRY NOSE.Headache 8(4)1171-4, Jan 1969. A 10694 Sander, J., Schweinsberg, P., and A 10633 Menz, H-P. Sydnor, K. L. and Flasher, J. W. UNTERSUCHUNGEN USER DIE ENTSTEHUNO COMPARATIVE BIOLOGIC ACTIVITIES OF CANCEROGENER NITROSAMINE IM MAGEE. 7,12-DINETHY1EF2i2(a)ANTHRACENE, 7- (STUDIES ON THE FORMATION OF HYDROMCKTHYL-12-XITHYIBENZ(a)ANTHRACENE, CARCINOGENIC NITROSAMINES IN THE 7,12-DIHYDROXYYJITHYIBENZ(a)ARTHRACENE, STOMACH.) Hoppe-Seyler's AND 4-METHOXY-7,12-DIMETHTLEENZ(a)- Z itschrift fur Physiorogische Chemie ANTHRACENE IN THE SPRAGUE-DAW1EY-FEKALE 7DecLAL irman RAT.Cancer Research 29(2) :403 -8, Feb (bs 1969. The treatment of secondary amines with nitrous acid in diluted aqueous A 10634 solution gives an optimum yield of Tully, G. W. and Briggs, C. D. nitrosamines between pH 1 and 3, which S.P.R. ABSORPTION BY THE VAPOUR PHASE OF corresponds to the conditions found CIGARETTE SMOKE, CONDENSED AND EXAMINED in the stomach of the human and AT LCW TENPpRATURES.Chemistr t0.4 various experimental animals. The ease Industry (7):201-3, FeS 15, 1969. of formation of the nitrosamines depends greatly on the basicity of the amine. Thus weakly basic amines were A 10656 converted into nitres() compounds up Morrison, C. P. to one thousand times as readily as EFFECTS OP NICOTINE ON MOTOR CO-ORDINATION strongly basic amines.The synthesis AND SPONTANEOUS ACTIVITY /N MICE. of nitrosamines in the stomach of experimental animals could be i0 MDA.1 t Ph4rm40X sal 111-_-__231 2IIIITS5=7, 'Jan 1969. demonstrated by various methods when the standard diet was supplemented with nitrite and secondary amines, pro-

20 A 10694 (continued) A 10708 (continued) viding secondary amines of fairly sensitive, particularly if its low basicity were used.When strongly structure basically is unstable. basic diethylamine was used, the Dysregulations of the autonomic formation of the corresponding nervous system as a rule indicate very nitrosamine could be shown neither early the beginning aging of the central chemically nor in the animal experiment. and autonomic nervous system, the Production of malignant tumours pathosclerotic episode, long before through the formation of nitrosamines this can bG detected by objective in the stomach can generally only be clinical findings. (Author Abstract) expected, if nitrite is present In the stomach at the same time as secondary amines that react relatively A 10712 easily with nitrous acid and whose Weissmann, 0., Troll, W., van Duuren, nitroso compounds are sufficiently B. L., and Sessa, 0. carcinogenic. (Author Abstract) STUDIES ON LYSOSOMES--X. Effects of Tumor-Promoting Agents Upon Biological and Artificial Membrane Systems. A 10706 Biochemical Pharmacology 17(12)8 Oarkav1, L. 2421-34, Dec 1968. 3aig4EWE atm PAUPAIEHAsi 11410TAIWOCA Ally nonykietis riPOT143001)1cOrE801-0 3.44EKTA. A 10731 Seidel, H. J. 2NACHENIYE SILY RA2DRAZHENIYA LEBER-REGENERATION NACH DIATHYL- GIPOTALAMUSA DLYA POLUCHENIYA NITROSAMD4-VEROIFTUNG. (LIVER PROTIVOOPUKHOLEV000 EFFEXTA. (THE REGENERATION AFTER DIETHYLNITROSAMINE SIONIFICANCE OF THE DEGREE OF POISONING.) Naturwlasenschaften STIMULATION OF THE HYPOTHALAMUS FOR 55(11)1548, Nov 1968, OerwanlAbs.) OBTAINING AN ANTITUMOR EFPECT.) Biulleten, Ekeperimental,Noi Biolo iii Dietylnitroaamine (DENA, 100 mg/ Meditsiny 66(11):95-8, R617 1x68,, kg, 30 percent of LD60) was administered Prussian (Abs.) by esophageal sound to 10 female Electrical stimulation of Wieter rata; 2 rats were killed after 1,2,3,5, and 7 days; 2 others served hypothalamus of average intensity, as as controls; 1 hour before death all differing from week, "threshold" 12 animals were administered 170 and strong "stresaor" leads to microC 3H-thymidine intravenously. resorption of tumours Ln rats: Autoradlographic tests showed that sarcoma 45 and sarcoma BP-1 (3rd, 4th the 3H-thymidine index of parenchymal and fifth generation) induced by and mesenchymal cello rose sharpy 3,4-benzpyrene. It is suggested that 48 and 72 hours after administration of a special general nonspecific adoption "reaction of activation' arises. DENA. The values were still above normal, after 5 and 7 days. Parenchymal (Author Abstract) cell mitosis ran a parallel course. The histological study of the pattern of liver regeneration after administra- A 10708 Pierach, A. tion of the toxic dose of DENA did not ZVR VEGETAT/VEN ANAMNESE UND differ essentially from that following the administration of carbon tetrachloride SYMPTOMATIK BEIM ALTERNDEN MENSCHEN. (VEGETATIVE MIMESIS AND SYMPTOMS which had been studied earlier. IN AG/NO PEOPLE. 2eitechrift fur Oerontologla 1(5 :289-96, Sep -1T58, A 10732 barman (Abs.) Madronero, R. SINTESIS Y ESTUDIO DE NVEVOS The autonomic nervous system is an extremely sensitive structure GANGLIOPLEJICOS. (SYNTHESIS AND STUDY CF NEW DANOLICWOPLEGICS.) Anales Al la Which at present experiences a general increase in its sensitivity due to Real Academia de l'araciiSTMII73:95, the so-called civilization-induced TOTT,-*TrTreg Tna. Its dysfunctions are moat damages. Various chemical structures have easily explained by sel4a1ve been tested as ganglionoplegio frequently complicated case histories, compounds.Several have been cited particularly since the dysfunctions for their antinicotinic properties. usually are only transitory. With advancing age It usually gets more

21 A 10754 A 10765 (continued) Dontenwill, W. acceptance. Any lipid in a living EXPERIMENTAL STUDIES ON THE ORGANOTROPIC body exists in the form of lipoprotein, EFFECT OP NITROSAMINES IN THE therefore, if the lipid in the sclerotic RESPIRATORY TRACT. Pod and Cosmetics lesion is to have been derived from Toxicology 6(5)1571, Dec 1'O87 blood, the process may have been accomplished through lipoprotein. There have so far been few reports A 10755 concerning the influx of lipid into Magee, P. N. the aortic endothelium studied with POSSIBLE MECHANISMS OF CARCINOCENESIS radioactive cholesterol as a tracer. BY N-NITROSO COMPOUNDS AND ALKILATING In the present investigation, the influx AGENTS. Food and Cosmetics Toxicology ot lipid in the form of lipoprotein 6(5)1572 -S DDec T96 U was studied both in vitro and in vivo.

A 10756 A 10771 Roe, F. J. C. Stanescu, D., Teculescu, D., and SENSITIVITY OF NEWBORN MICE TO PacLraru, R. CARCINOGENIC AGENTS. Food and REPRODUCIBILITY AND NORMAL VALUES Cosmetics Toxicology 6TSITOT:2, Dec OP THE SINGLE BREATH NITROGEN 1968. TEST. Scandinavian Journal of Respiratory Diseases 49(4):372-3O, 1168. A 10757 Napalkov, N. P. EXPERIMENTS WITH DIFFERENT CARCINOGENS A 10774 IN PREGNANT ANIMALS. EFFECT OF Woods, D. A. and Smith, C. J. BLASTOMOGENIC SUBSTANCES ON THE ULIRASTRUCTURE OF THE DERMAL- ORGANISM DURING THE PERIOD OF EFBRY0- EPIDERMAL JUNCTION IN EXPERI- GENESIS. Food and Cosmetics Toxicology MEITALLY INDUCED TUMORS AND 6(5)1582-47-No 1V6T7------HUMAN ORAL LESIONS. Journal of Investigative DerannE7 r2(3)i259-63, -Mar 1969. A 1075b Ivankovic, S. and Drucicrey, H. CARCINOOENESIS IN THE PROGENY AFCER A 10777 EXPOSURE OP PREGNANT ANIMALS. 17,yad Kershbaum, A., Pappajohn, D. J., and Cosmetics Toxicology 6(5):58 75, Osadn, H., and Belle, S. 'N-E 1968. EFFECT OF SMOKING sAD NICOTINE ON THE CRYSTALLIZATION OF CHOLESTEROL. Acta Cerdiologica A 10765 25(6)i548-57, TUN. Higuchi, K. DOMYAKU KOKABY0 NO SEI-IN NI KAMAJRU KENKYU. DA1D0MYAKUMEKI E NO KESIEI A 10776 RIPOTAMAPAKUSEI TORIKOMI NI TSUIIA Newman, R. H., Jones, W. L., and (STUDIES ON THE GENESIS OF Jenkins, R. W., Jr. ATHEROSCLEROSIS.THE INTAKE OF SERUM AUGOMATIC DEVICE FOP THE EVALUATION LIPOPROTEIN BY THE AORTIC WALL.) OF TOTAL MAINSTREK-' cIOARETTE SMOKE. Nippon Junkankigaku -ehi 32(8)*1171-9, Analytical Chemistry 41(5):546-5, Aug 1968, Japanese (Abs.) Tarr 116f.

There are a number of factors participating in the pathogenesis of A 10781 arteriosclerosis, and it has been UougIss, J. S. and Dennis, M. W. immunologically and dietetically HISTAMINE RELEASE BY AIR POLLUTANTS. established, through experiments Archives of Environmental Health 18(4)1 on animals, that lipemia and a lirr:M7-Apr 1969. chronological factor play important roles. As to the origin of the 1:4id deposited on the sclerotic lesion A 10789 opinions are diversifiedi Some Andersen, R. A. and Moegling, O. attributing it to blood , others to QUOTITAT/VE OAS CHROMATOGRAPHIC the synthesis in the arterial wall ASSAY FOR CAPFEIC ACID MOIETIES IN and so forth, but at pre ent the TOBACCO. Analytical Biochemistry former seems to have gained general 27(3)t397-408, Mar 1549.

Qw A 10822 (continued) A 10796 in Normal and Cancer Tissues, Foci and Cosmetics Toxicology. Proceedings of the Symposium on Nucleic SYNERGISM IN CARINOOENESIS. Food and Acid and Medicine, Tokyo, Japan, Aug Cosmetics Toxicology 6(4):520-3, 17, 1967.Gann Monograph No. 6, 1968, Dec 1968. pp. 49-64.

A 10808 A 10826 Wyuchenok, R. Yu. and Bannikov, 0. N. CohPn, B. and Smith, C. J. 11114FIIIEX0,514EPnikECKNX macTe HA 13/031EKTPY46C AETIOLOGICAL FACTORS IN ORAL CANCER: KyVAIONMAXTbatattECKWONC117b4 EXPERIMENTAL INVESTIGATION OF EARLY EPITHELIAL CHANGES.Helvetica VLIYANIE KHOLINERGICHFSKIKH polo gal Ac Ig 11(1)1112-24, Apr VESHCHESTV NA BIOELEXTRICHESKINU AKTIVNOST, LIMBICHESKOY SISTEMY. (THE EFFECT OF CHOLINERGIC SUBSTANCES ON THE BIOELECTRIC ACTIVYTY OF THE A 10831 LIMBIC SYSTEM.) Biulleten' Schievelbein, H., (Editor). Eks erimentalsnol Bielomi1 1 NIKOTIN. Pharmakologie and sing, 66(12-1155-60, Dec 1968, Toxikologie des Tabakrauches Russian (Abs.) (Nicotine. Pharmacology and Toxicology of Tobacco Smoke.) Administration to rabbits of Stuttgart (West Germany), Georg Thieme anticholinesterase (eserine, Verlag, 1968, 333 pp., Oerman (Abs.) galanthamine) and cholinomimetic agents (arecoline, oxotrem.rine, The book, which is intended for nicotine) brings on the appearance of the practicing physician, presents theta-rhythm on the EEO of the the present status of the Smoking hippocampus, septum, median and and Health" problem concerning the posterior portions of the gyrua pharmacological action of tobacco cingull, optic region of the cortex smoke constituents in animals and and of the pontomesencephalic reticular humans. Most of the data has been formation. On the EEG of the senso- verified either experimentally or motor region of the cortex, anterior statistically, but additional data portion of the gyrus cingull and of the have been included which, while disputed tonsil complex a frequent, low- by outstanding physicans, were of amplitude rhythm is recorded.The EEO- value in stimulating interest on the activation reaction is blocked with subject. The data have been presented =ley' and bensacine. Premesencephalic under the following broad headings: section does not eliminate the theta- Biochemical and pharmacological basis for rhythm, provoked by the anticholinesterase the effect of tobacco smoke components and cholinomimetic substances in the on the organism; the tobacco habit; structures of the limbic system and in the brief introduction to statistics with severed reticular formation, whereas in special consideration to epidemiology; the new cortex there remain slow high- tobacco smoking and mortality; effect of amplitude waves. The destruction of the smoking on organ systems and their posterior hypothalamus in premesencephalic specific diseases; and the investigations sections precludes an emergence of theta- of the tobacco industry. rhythm in the limbic system. The authors attach great importance to the activity of the limbic system to its proper cholinergic A 10832 mechanisms. (Author Abstract) Werle, E. and Schievelbein, H. EINLEITUNO (INTRODUCTION,) Ins Schievelbein, H. (Editor).Nikotln: A 10812 Pharmakologie and Toxikologie des Shibata, S. Tatekrauches. Stuttgart (West Oermany), EFFECT OF fROLONOED COLD STORAGE Georg Thieme Verlag, 1968, pp. 1-4., ON THE CONTRACTILERESPON6EOF German (Abs.) STRIPS OF RABBIT AURTA TO VARIOUS AGEWS. Circulation Research 24(2): This introduction by the editor 179-87, Feb 1969. and one of the coauthors sets out to clarify the purpose in iteeng the book and to explain the self - imposed A 10822 limitations in scope.The book is Niigata, C. and Kodams, M. intended to present the practicing INTERACTION BETWEEN NUCLEIC ACIDS AND physician with pharmacological data ORGANIC MOLECULES. In: Nucleic Acid regarding the effects of tobacco smoke constituents on individual

23 A 10832 (continued) A 10835 organ systems. There is also a brief Herz, A. survey of the action taken by several NEUROPHARMAKOLOGIE UND PSYCHOPHARMA- foreign countries (including the United KOLOGIE DES NIXOTINS. (NEUROPHARMA- States) in labeling of cigarettes COLOGY AND PSYCHOPHARMACOLOOY OF and banning tobacco advertising. NICOTINE.) In Schievelbein, H. (Editor). Nikotint Pharmakologie und Toxikologie des Tabakrauches. A 10833 Stuttgart (West Germany), Georg Neurath, G. Thieme Verlag, 1968, pp. 30-42., TABAARAUCH BILDUNO, ZUSAMMENSET2UNG German (Abs.) UND FILTRATION. (TOBACCO SMOKE- FORMATION, COMPOSITION AND FILTRATION.) The action of nicotine on the In: Schievelbein, Ha (Editor). Nikotint central nervous system was reviewed. Pharnakologie und Toxikologie des Neuropharmacological studies dealt Tabakrausches. Stuttgart (West Germany), with the action of nicotine on spinal Georg Tnieme Verlag, 1968, pp. 5-19, reflex, medullary function and German (Abs.) electrical activity of the brain as well as its action in causing tremors Filter and nonfilter cigarettes and cramps. Psychopharmacological were conditioned at 20 degrees C and studies dealt with the action of 67 percent relative humidity and then nicotine in influencing motility, the smoked under standard conditions of 1 waking- sleeping cycle, conditioned puff every 2 seconds and 35 ml. Puff reactions, and complex behavior patterns volume. Components of the smoke as well as animal tests on self- were identified by gas chromatography. administration of nicotine, direct and The effectiveness of several simple indirect central action of nicotine, filter materials was evaluated. nicotine antagonists and dosage problems with respect to smokers. Much of the recent data was discussed at the 10834 "Conference on the Effects of Nicotine Schievelbein, H. and Smoking on the Central Nervous NIKOTIN--RESORPTION, STOFFWECHSEL UND System' that was held in New York in AUSSCHE1DUNO. (NICOTINE--RESORPTION, tpril 1966. METABOLISM AND EXCRETION.) Int Schievelbein, H. (Editor). Nikotini Pharmakologie und Toxikologie des A 10836 Tabakrauches. Stuttgart (Vest Germany), Schievelbein,. H. Georg Thieme Verlag, 1968, pp. 20-9, PHARMAKOLOOISCHE WIRKUNGEN DES German (Abs.) NIKOTINS AUF ORGANSYSTEME. (PHARMA- COLOGICAL ACTION OF NICOTINE ON ORGAN Metabolism of nicotine in animals and SYSTEMS.) In Schievelbein, H. humane was reviewed. Distribution of (Editor). Nikotint Pharmakologie und intravenously-injected 14C-nicotine was Toxikologie des Tabakrauches. Stuttgart investigated autoradiographically. (West Germany), Georg Thieme Verlag, Twenty to thirty minutes after 1968, pp. 43-52., German (Abs.) administration, there was a virtual disappearance of nicotine from some The demonstrable action of tobacco tissues and a concentration in other smoke depends essentially on the tissues. Detoxification was less properties of nicotine. The present evident in younger and older animals work deals only with the action of than in those of middle age.Nicotine nicotine which can be demonstrated metabolism was investigated it suckling under smoking conditions in humans animals; nicotine detoxification was or which are of significance in the found to be greatest in the liver. A etiology or diseases.The action of schematic diagram illustrates degradation nicotine has been studied in the heart routes in suckling animals. The condi- and circulatory system, lungs and tions influencing resorption of nicotine respiration, glands of internal from cigarette smoke in human smokers secretion and stomach and intestines. were listed. In humans, a maximum of 10 The peripheral pharmacological percent (generally much lower) of nicotine mechanism of action was also WAS excreted through the urine.Excretion varied with the nicotine supply and the pH of the urine. Excretion of nicotine A 10837 was greater in cigarette smokers (due to Brugsch, H. inhalin;) than in the other groups. AKUTE NIXOTIK/ERGIFTUN3 BEIM MENSCHEN. Nicotine WAS also excreted through the (ACUTE NICOTINE POISON/NO IN HUMANS.) milk. Int Schievelbein, H. (Editor).

2.4 A 10839 (continued) A 10837 (continuad) Nikotint Pharmakologie und Toxikologie The carcinogenic activity of tobacco des Tabakrauches. Stuttgart (West smoke condensates could be demonstrated Germany), Georg Thieme Verlag, 1968, by painting the skin of mice and pp. 53-6., German (Abs.) rabbits or by subcutaneous infection into rats: Introduction of tobacco Symptoms, diagnosis and treatment smoke condensates into the respiratory of nicotine poisoning were described. tract resulted only rarely in cancers, Nicotine-habituated individuals although "precancerous states" such as generally have a more favorable squamous cell metaplasia or "carcinoma prognosis; 24-hour survival after in situ" could be observed. There is intake of the poison is also No specific changes in still no conclusive evidence of encouraging. carcinogenic action after inhalation of body organs can be found on autopsy tobacco smoke and the mechanism of but frequently one can observe signs action in carcinogenesis ''as not been of asphyxiation due to subpleural and enic activity The presence estaalished. The carol: lung tissue bleeding. of various components of 'obacco of nicotine can be detected by chemical smoke such as 3,4-benzopyrene, radio- methods from stomach contents, organ active polonium, arsenic, nitrosamines extracts and body fluids. Verification of diagnosis Nu be made from urine and nickel carbonyl was treated briefly. prior to chemical treatment or from Various chemical methods are vomit. A 10840 available for Qualitative analysis of nicotine but quantitative determinations Schievelbein, H. by spectrophotometry have replaced older WIRKUNG DES RAUCHENS UND DiS NIKOTINS AUF DEN STOFFWECHSEL. chemical methods. (ACTION OF SMOKDING NICINE ON THE METABOLISM.) IANnt SchieOTvelbein, H. (Editor). Nikotin: Pharmakologie A 10838 und Toxikologie des Tabakrauches. Dalhamn, T. Stuttgart (West Germany), Georg Thieme WIRKUNGEN DES TABAKRAUCHES AUF DAS Verlag, 1968, pp. 70-4., German (Abs.) EPITHEL DER OBEREN LUFTWEOE. (ACTION OF TOBACCO SMOKE 01 THE EPITHELIUM The following topics were reviewed OF THE UPPER RESPLiATCBY TRACT.) In: Nikotint briefly: Rise in blood sugar after Schievelbein, H. (Editor). ntagonism of the anti- Pharmakologie und Toxikologie des smoking; Stuttgart (West Germany), convulsiv:, antidiuretic and the Tabakrauches. ganglionostimulating action of nicotine Georg Thieme Verlai, 1968, pp. 57-61., by thiamin) reduced content of ascorbic German (Abs.) acid in the blood of smokers the greater The ciliastatio action of whole excretion of thiocyanates in smokers than smoke or its principal constituents in nonsmokers) anticholinesterase on various tracheal tissues was activity of nicotine; action of cigarette All authors were in agree- smoke on the metabolism of ethyl alcohol reviewed. in yeast cultures) and the action of ment concerning the ciliastatic action of the different substances but there was nicotine on the alcohol content of The action of nicotine on other no clear concensus concerning the blood. relative inhibitory powers of the gas or enzyme systems was also mentioned. particulate phase of the smoke or of the components. At present, there is no certainty as to whether inhalation of cigarette smoke non:ally results in the A 10659 Dontenwill, W. and Weber, K. H. inhibition of cils.:7 movement or secretory transport and whether such FORSMNGSARBEITEN DER inhibition promotes the incidence of ZIGAREPTENINDUSTRIE. (RESEARCH OF THE In: Schievelbein, disease. TOBACCO INDUSTRY.) H. (Editor). Nikotin: fharmakolrgie und Toxikologie des Tabak-auches. Stuttgart (West Germany), A 10839 Schmahl, D. Georg Thieme Vrlag, 1968, pp. Donlan (Abs.) EXPERIMENTELLE TABAKKARZINOOENESE. 293-320., TOMACCO CAREdiIoCNCOENESIS.) Research of German cigarette IEXPERIMENTALnt Schievelbein, H. (r). Pharmakologie und Toxikologie industry was reviewed.Several tables Nikotin: give the results of the application of des Tabakrauches. Stuttgart (west Germany), Georg Thleme Verlag, 1568, individual compounds, condensate fraction and whole condensates to research anirals pp. 62-9., Germ, (Abs.) and smoke inhalation tests in re:ea:ch animals.

21 A 10861 A 10879 Sladek, N. E. and Mannering, 0. J. Mombelli, L., Bergonzi, M., and Roncari, O. INDUCTION OP DRUG METABOLISM. 1. ANALYSIS OP A QUANTITATIVE MODEL OF THE DrPFEREN1ES IN THE MECHANISMS BY WHICH KINETICS OP SELENIUM IN LABORATORY POLYCYCLIC hYDROCARBONS AND PHENOBARBITAL ANIMALS. Radioaktive _Ieeotope in Klinik

PRODUCE THEIR INDUCTIVE EFFECTS ON und Forachung 8:195-2 , . MICROSOMAL N- DEMETHYLATING SYSTEMS. Molecular Pharmacology 5(2):174-85, Mar 1969. A 10883 Krarup, T. 00CYTE DESTRUCTION AND OVARIAN A 10862 TUMORIGENESIS AFTER DIRECT APPLICATION Flake, A. OF A CHEMICAL CARCINOGEN Vs10- THE SUSCEPTIBILITY OF VARIOUS STRAINS OF DIMETHYL-112-BENZANTHRENE TO THE NEONATAL MICE TO THE CARCINOGENIC MOUSE OVARY. International Journal of EFFECTS OF 9,10-DIMETHYL-1,2-BFNZ- Cancer 4(1):61-75, Jan 15,'1969-:-- ANTHRACENE. European Journal of Cancer 4(0:579-85, ec A 10892 CMD Medical Digest. A 10868 RISK OF LUNG Ca IN FILTER CIGARETS. Archer, F. L. CMD Medical Digest :228, Mar 1969. PINE STRUCTURE OF SPONTANEOUS AND ESTROGEN- INDUCED SECRETION IN BREAST TUMORS IN THE RAT INDUCED BY 7,12- A 10895 DIMETHYLBENZ(a)_ANTHRACENE. Journal of Lijinsky, W., Tomatis, L., and the National Cancer Institute-17M: Wenyon, E. M. n-r-w-maT-1. WY= LUNG TUMORS IN RATS TREATED WITH N- NITROSOKEPTAMETHYLENEIMINE AND N- NITROSOCCTAMETHYLENEIMINE.Proceedin a A 10871 of theSocietyfor gjirimen a Dalhamn, T. groTE- nd Medreche 130(3):945-9, Mar THE ANTICILIOSTATIC EFFECT OF CIGARETTES TREATED WITH OXDIAMINE CITRATE. American Review of Respiratory Dieseaess 91131TM:17"Wr -row. A 10900 Wheatley, D. N. EFFECT OF dl-ETHIONINE AND NATURALLY A 10872 OCCURRING AMINO ACIDS ON ADRENAL NECROSIS Schievelbein, H., Werle, E., Schulz, E. K., INDUCED BY 7,12-DIM ETHYLBENZ(a)ANTHRACENE and Baumeister, R. AND ITS 7 -HYDROXYMETKYL DERIVXTIVE IN THE INFLUENCE OF TOBACCO SMOKE AND FEMALE SPRAOVE-DAWLEY RATS. British NICOTINE ON THIOCYANATE METABOLISM. Journal of Experimental Pathology VogicSchmiedebergs Archly fur 50(1):78:33, Feb 1959. orogle and Expi771-WtinTe riThologle252r37:t514-55, 1959. A 10901 McLean, A. E. M. and Verechuuren, H. G. A 10875 EFFECTS OF DIET AND MICROSOMAL ENZYME Ivanov, N. and Ognyenov, I. INDUCTION CV THE TOXICITY OF DIMETHYL PHYTOSTEROLS AND THEIR ESTERS IN RESINS NITROSAMINE. British Journal of OF BULGARIAN ORIENTAL TOBACCO. Doklady Experimental pi11171151gy 5011):2M, Bul rska Akademii Nauk Compluspandue Peb 1969. 87:707111.617-

A 10903 A 10876 Chakraborty, M. K. Zimmermann, P. K. COMPOSITIONS OF THE VOLATILE OILS GENETIC EFFECTS OF POLYNUCLUR OBTAINED FROM DIFFERENT VARIETIES OF HYDROCARBONS: INDUCTION OF MITOTIC TOBACCO. Indian Journal of Technology, GENE CONVERSION. Zeitschrift fur 6(9):281-27-nrIgm--- Krebsforschung 72 I1):65-71, 1177.

A 10905 Lawrence, P. J. CATALYSIS OP DISULFIDE INTERCHANGE IN

22 2t. A 10933 (continued) A 10905 (continued) AVAILABLE IN CANADA. Cancer 23(4):910- ACID MEDIA BY SELENIUM AND TELLURIUM OXY 2, Apr 1969. ACIDS. Biochemistry 8(3):1271-6, Mar 1969. A 10934 Hennings, H. and Boutwell, R. K. A 10907 THE INHIBITION OF DNA SYNTHESIS BY Gabridge, M. O. and Legator, M. S. INITIATORS OF MOUSE SKIN TUMORIGENESIS. A HOST- MEDIATED MICROBIAL ASSAY FOR THE Cancer Research 29(3)1510-4, Mar 1969. DETECTION OF MVIAOENIC COMPOUNDS. Proceedings of the Society for ins perimental-BiErtgy an A 10935 130(3)1831-1, Mar 1-909. Swain, A. P., Cooper, J. E., and Stedman, R. L. LARGE-SCALE FRACTIONATION OF CIGARETTE A 10908 SMOKE CONDENSATE FOR CHEMICAL AND Masuda, Y. and Hoffmann, D. BIOLOGIC INVESTIGATIONS. Cancer Research QUANTITATIVE DETERMINATION OF 1- 29(3):579-83, Mar 1969. NAPHTHYLAMINE AND 2-NAPHTHYLAMINE IN CIGARETTE SMOKE.Analytical Chemistry 41(4)1650-2, Apr 1960. A 10936 Bock, F. 0., Slain, A. P., and Stedman, R. L. A 10912 BIOASSAY OF MAJOR FRACTIONS OF CIGARETTE Jaffe, W. O. and Mondragon, M. C. SMOKE CONDENSATE BY AN ACCELERATED ADAPTATION OF RATS TO SELENIUM INTAKE. TECHNIC. Cancer Research 29(3):584-7, Journal of Nutrition 97(4)1431-6, Mar 1969. Apr 1969.

A 10937 A 10926 Dymicky, M. and Stedman, R. L. Pataki, J. and Huggins, C. COMPOSITION STUDIES ON TOBACCO. XXXV. MOLECULAR SITE OF SUBSTITUENTS OF MOIETIES IN LEAP AND SMOKE CONDENSATE. BEN2(a)ANTHRACENE RELATED TO CARCIN- PIGMENTS: ACIDS. Tobacoo 168(15)128-30, OGENIUITY.Cancer Research 29(3): Apr 11, 1969. 506-9, Mar 1969.

A 10938 A 10928 Smith, E. R. and Ilievski, V. Shimkin, M. B., Oruenstein, M., Meranze, THE STIMULATION OF CANINE PROSTATIC D. R., Acuff, M., and Thatcher, D. SECRETION BY SUBSTANCES WITH GANGLION- THE EFFECTS OF SCHEDULE AND DOSE OF STIMULATING ACTIONS. Proceedings of 7,12-DIMETHYLBEN2(a)ANTHRACENE ON THE the Societ for Exrimental Biology INDUCTION AND GROWTH OF MAMMARY CARCINOMA and c -130(2J:pe66.7-71,-Feb1969. IF SPRAGUE -DAWLEY FEMALE RATS.Cancer Research 29(3)1503-5, Mar 1969. A 10940 Yuhara, K. A 10931 AN ARTIFICIAL TOBACCO FREE FROM NICOTINE. KaNachl, T., Hirata, Y. and Sugimura, T. British Patent No. 1,115,369, May 29, ENHANCEMENT OF N-NITROSODIETHYLAMINE 1968, 2pp. HEFATCCARCINOOENESIS BY L-TRYPTOPHAN IN RATS. Gann 59(6)1523-5, Dec 1968. A 10941 Prodi, O. A 10932 INTERA2/ONE FRA CANCEPOGENI CHIMICI E Yanai, R. and Nagasawa, H. ACIDI NUCLEIC'. (INTERACTION OF PROLACTIN AND GROWTH HORMONE LEVELS IN CHEMICAL CARCINOGENS AND NUCLEIC ACIDS.) THE ANTERIOR PITUITARY OF RATS BEARING Trork 54(5):396-8, Sep-Oct 1968, MAYNARY TUMOR INDUCED BY 7,12-DIMETHYL- Italian (Abs.) BENZ(a)ANTHRACENE. Gana 59(6):543-6, Dec 11568. The interaction of 4 labeled carcinogens with nucleic acids of rat organs were investigated. All com- A 10933 pounds were administered intra- Forbes, W. F., Robinson, J. C. and peritoneally and their stable bonds with .:;tanton, M. the nucleic acids of the liver, kidney, TAR AND NICOTINE RETRIEVAL FROM CIOARETTLS spleen, 'mg, and sometimes the akin,

23 A 10941 (continued) A 10949 noted 3'-Methyl-E-dimethylaminoazobenzene: Hoffmann, D., Rathkamp, 0., and Woziwodzki, DNA was active in all organs with H. maximam activity in the liver.Benz(a)- CHEMICAL STUDIES ON TOBACCO SMOKE. pyrenes activity linked with DNA was VI. The Determination of Carbazoles in but determinable; the same order Cigarette Smoke. 13eltLAaLe zur of activity was present in the liver, Tabakforschung 4(611253-43,-Mv 1968. kidney, spleen and skin tth lesser activity in the lung. 7,12-Dimethyl- benz(a)anthracenet results were A 10950 comparable to those obtained with Guthrie, F. E. benzopyrtne. Ethyl carbamates only THE NATURE AND SIGNIFICANCE OF PESTICIDE preliminary results were reported. RESIDUES ON TOBACCO AND IN TOBACCO SMOKE. Beitrage zur Tabnkforechung 4(6):229-46, Nov mt. A 10946 Calendi, E. and Santamaria, L. INTERAZIONE DEL BENZO(a)PIRENE E DI A 10951 ORMONI STEROID' CON MITOCONDRI ISOLATI Buser, H. DI FEOATO DI RATIO. (INTERACTION OF WASSERBESTIMMUNO IM RAUCHKONDENSAT BENZO(a)PYRENE AND STEROID HORMONES NACH KARL FISCHER MIT ETHER WITH MTTOCHONDRIA ISOLATED FROM RAT HALBAUTOMATISCHEN APPARATUR. (DETER- LIVER.)Tumori 54(5):395-6, Sep-Oct MINATION OF WATER IN SMOKE CONDENSATE 1968, ItaTTErrAbs.) WITH A KARL FISCHER SEMIAUTOMATIC APPARATUS.)Beitrage zur Tabakforschunp, The swelling action of benze(a)- 4(6)1264-7, Nov 1967, nilman (Abs.) pyrene on the mitochondria of rat liver following exposure to light was The current method of determination reviewed. Extension of the study to of the water content of cigarette the swelling action of 12 steroid smoke condensate was improved by using hormones was then reviewed. The a Karl Fischer titrator with automatic possible competition between hormones end-point stop.The overall procedure and carcinogenic polycyclic hydrocarbons thus becomes faster (the titration was then investigated. The experiments time is less than 2 minutes), easier showed that pretreatment with estradiole (no supervision is needed during the protected the mitochondria from swelling titration) and better reproducible caused by benzopyrene and by 7-methyl- (coefficient of variation 2.5 percent 3,4 benzophenanthrene in light.The on the amount of water determined). same phenomena was verified with estrone In these three criterions, the automated but the other steroids were inactive in Karl Fischer method le superior to a this respect. These results are of gas-chromatographic procedure having significance in relation to the reported served as a method of comparison. in vivo competition between carcinogenic (Author Abstract) Eidnierrbons and steroid hormones in the therapy of experimentally-induced mammary carcinomas. A 10952 Neureth, 0., Oewe, J., and Wichern, H. USER DAS VORKOMMEN VON HYDROAROMATEN A 10947 IM TABAKRAUCH. (THE OCCURRENCE OF P. Lorillard Company. HYDROAROMATIC COMPOUNDS IN TOBACCO NOUVEAUX PRODUITS DE TABAC. (NEW SMOKE.) Beitrage zur Tabakforschuns TOBACCO PRODUCTS.)French Patent No. 4(6)2250Z, Nov 1958; German (Abs.' 1,5C4,760, Nov 6, 1967, 3 pp., French (Abs.) Indan, 1-methylindan, 2-methylindan, 1,2,3,4-tetrahydronaphthalene, The patent covers a tobacco im- 1-methyl-5,6,7,8-tetrahydronaphthalene, pregnated with an oxadiazole derivative 2-methyl-1,2,3,4-tetrahydronaphthalene, intended to inhibit the ciliostatic and benzyl cyanide have, for the first effect of tobacco smoke. The specific time, been isolated from the smoke of derivative cited in the patent claim normal blended cigarettes by a was the citrate of 3-pheny1-5-(1- ccmbination of gas chromatography diethylaminoethyl)-1,2,4-oxadiszole. and mass spectrometry. Four isomers Results of tests of the product on of methylindan, four isomers of cats in filter and nonfilter cigarettes dimethylindan, one ethylindan, and one were reported. methyltetralin could not be exactly identified on the basis of the mass spectra alone. (Author Abstract)

24 ai A 10953 A 10966 Neurath, G., Gewe, J., and Wichern, H. Wong, S., Long, J. P., and Gross, E. G. USER DAS VCRKOMMEN VON BENZOFURANEN ANTAGONISM OF THE AURICULAR STIMULATING IM TAEAKRAUCH. (THE OCCURREN E OF ACTION OF NICOTINE BY ALITA,ALPHA'-EIS- BENZOFURANS IN TOBACCO SMOKE. (DIMETHISAMMONIUMACETAEUERTD7---- Beitrage zur Tabakforschung 4 6)1 DIETKYIACETAL)-2,E,-DIACETYLBIPHENYL 247-9,7vo7-1"968, German 1Abe. BROMIDE, DMAE. Archives Internationales de Pharmacodynamri-Ern TerEmti Benzo-(b)-furan as well as three 76(2):425-33, Dec MT: isomers of methylbenzo-(b)-furan and three isomers of dimethylbenzo-(b)- furan have been detected in the smoke A 10967 of normal blended cigarettes by a Matsumura, S., Taira, N., and combination of gas chromatography and Hashimoto, K. mass spectrometry. The isomeric THE PHARMACOLOGICAL BEHAVIOR OF THE compounds could not be exactly identi- URINARY BLADDER AND ITS VASCULATURE fied on the basis of the mass spectra OP THE DOG.Tohoku Journal of alone. (Author Abstract) Experimental nainhe v6(31:2r7-58, Nov 1968.

A 10957 Olds, M. E. and Domino, E. P. A 10971 COMPARISON OF MUSCARINIC AND NICOTINIC Roe, P.J.C., Carter, R. L., and CHOL/NERGIC AGONISTS ON SELF-STIMULATION Adamthwaite, S. BEHAVIOR. Journal of Pharmacology and INDUCTION OF LIVER AND LUNG TUMOURS Experimental 165(E)11877- IN MICE BY 6-AMINOCHRYSENE ADMINISTERED Nature 04, Apr 1969. DURING THE FIRST 3 DAYS OF LIFE. 221(5185);1063 -4, Mar 15, 1969.

A 10958 Connecticut Medicine. A 10976 THE EFFECTS OP CARBON MONOXIDE ON HUMAN Gebber, O. L. HEALTH. Connecticut Medicine 33(2) :90 - NEUROGENIC BASIS FOR THE RISE IN 2, Feb 195 77------BLOOD PRESSURE EVOKED BY NICOTINE IN THE CAT. Journal of Pharmacology and ExperiEZETWT-Tnrapeutics 166(2): A 10961 zrr-s5, Apr 1969. Levander, O. A. and Argrett, L. C. EFFECTS OP ARSENIC, MERCURY, THALLIUM, AND LEAD ON SELENIUM METABOLISM IN A 10979 RATS. Toxicology and A lied Oliverio, A, NEURCHUMCRAL SYSTEMS AND LEARNING. pharmacology 14(2)73(8- , r 1969. U. S. Department of Health, Education, and Welfare, Public Health Service, A 10962 Washington, D. C., Public Health Service Van Duuren, B. L., Sivak, A., Katz, C., Publication No. 1836, 1969, pp. 867-78. and Melchionne, S. INHIBITION OP TUMOR INDUCTION IN TWO- STAGE CARCINOGENESIS ON MOUSE SKIN. A 10986 Cancer Research 294):947 -52, Apr 1969. Kato, R., Bruze, M., and Tegner, Y. CHROMOSOME BREAKAGE INDUCED IN VIVO BY A CARCINOGENIC HYDROCARBON -ISBONE A 10963 MARROW CELLS OF THE CHINESE Nishizuka, Y. HAMSTER. Hereditas 61(1-2)11-8, 1969. VIRAL AND CHEMICAL LEUXEMOOENESIS AND HOST DONDITIONINO. Acts Pathologies Japonica 18(3)1357-617-Fug 1968. A 1C987 Hood, L. V. S. and Winefordner, J. D. PHOSPHORIMETRIC INVESTIGATION OP A 10964 SEVERAL TRYFTOPHAN FETABOLITIES: Leuchtenberger, C. and Leuchtenberger, R. Determination of Kynurenic Acid in CYTOLOGIC AND CYTOCHENICAL EFFECTS ON Urine. Analytical Biochemistly 27(3): PRIMARY MOUSE KIDNEY TISSUE AND LUNG 523-9, Mar 1969. ORGAN CULTURES AFTER EXPOSURE TO WHOLE, FRESH SMOKE AND ITS GAS PHASE PROM UNFILTERED, CHARCOAL-FILTERED, A 11001 AND CIGAR TOBACCO CIGARETTES.Cancer Welsch, C. W. and Mattes, J. Research 29(4):862-72, Apr 1969. EFFECTS OF A MORE ODREL-MESTRANOL COMBINATION (ENOV1DON DEVELOPMENT

2$ A 11001 (continued) A 11014 AND GROWTH OF CARCINOGEN-INDUCED Bearden, J. H. MAMMARY TUMORS IN FEMALE RATS. Cancer SYNTHETIC TOBACCO: ALL OF INDUSTRY 23(3):601 .7, Mar 1969. MUST SHARE AVAILABLE DATA. Tobacco 168(17):65-7, Apr 25, 1969.

A 11003 Dandlya, P. C. and Bhargava, L. P. A 11015 THE ANTIPARKINSONIAN ACTIVITY OF Hagopian, M. and Rosenkrantz, H. MONOAMINE OXIDASE INHIBITORS AND RESPIRATORY TRACT RETENTION OF BLUE OTHER AGENTS IN RATS AND MICE. TETRAZOLIUM REDUCING SUBSTANCES FROM Archives Internationalee de TOBACCO SMOKE. Proceedings of the MIRNEFdynamie et de Then is Society for Experimental Sio' --Ind

176k11:157-67,-Nov . Medicine 30(4):1234 -T, Apr

A 11005 A 11018 Dontenwill, W., Elmenhorat, H., Cherry, C. P. and Glucksmann, A. Reckzeh, 0., Harke, H-P., and Stadler, L. THE INDUCTION OF CERVICO-VAGINAL EXPERIMMTELLE UNTERSUCHUNOEN UBER TUMOURS IN OESTROGENISED AND AUFNAHME, ABTRANSPORT UND ABBAU CANCER- ANDROOENISED RATS. British Journal OGENER KOHLENWASSERSTOFFE IM BEREICH of Cancer 22(4)1728-427M Mr-- DES RESPIRATIONSTRAKTES. (EXPERIMENTAL INVESTIGATIONS ABOUT THE INTAKE, TRANS- PORT, AND METABOLISM OF CANCEROGENIC A 11019 HYDROCARBONS IN THE RESPIRATORY TRACT.) Riopelle, J, L. and Jasmin, 0. Verhandlungen der Deutechen Oesellechaft NATURE, CLASSIFICATION, AND NOMENCLATURE TttrPatholTATe77:101 -8, 196 Cfrerr-ma-F--- OF KIDNEY TUMORS INDUCED IN THE RAT II's:I-- BY DIMETHYLNITROSAMINE. Journal of the National Cancer Instituter4117617-53; Concerning the question of whether Apr 1969. the results of the intrapulmonal applications of carcinogens are comparable with those obtained by application on the skin A 11020 the following problems have been investi- Ball, J. K. and Dawson, D. A. gated: The rate of resorption, removal BIOLOGICAL EFFECTS OF THE NEONATAL and elimination of DMBA and benzpyrene INJECTION OF 7,12-DIMETHYLBEN2(a)- from lungs after intratracheal applica- ANTHRACENE. Journal cf the National tion in different solutions and suspen- Cancer inatitin-4747117T9r7r5F-- sions and after pretreatment with eoot 77 injection or soot aerosols. The distribution of the applied substances and the compatibility of the applied solutions. A 11023 The concentration of benzpyrene in lungs Chiricuta, I., Mustea, I., Bojan, 0., after application as an aerosol and other and Simu, O. questions. (Author Abstract) CONSIDERATII BIOCHIMICE SI HISTOLOOICE ASUPRA hEPATOAMELCR DE MINIMA DEVIATIE, MUSE PRIN4-DIMETIL-AMINOAZOBENZEN A 11007 (DAB). (BIOCHEMICAL AND HISTOLOGICAL Volm, M., Kinzel, V., Mohr, U., and Suss, R. CONSIDERATIONS ON MINIMAL DEVIATION INACTIVATICR OF TISSUE-SPECIFIC INHIBITORS HEPATOMAS INDUCED BY,4-DIMETRYL- BY A CARCINOGEN (DIETHYLNITROSAMINE.) AMINOAZOBENZENE (DAB). Oncolo is si Experientia 25(Part 1):68-9, Jan 15, 1969. Radiologia 7(3)027-35, Many - Jun 9g!, Rumanian (Abs.) A 11012 A study was carried out on liver Tao, T. C. carcinogenesis induced by the daily LEAF TOBACCO COMPOSITION: THE administration of DAB, in doses of 10 POTENTIAL FOR GENETIC CHANGES. Tobacco mg/animal, for 12 months, determining 168(17)169-73, Apr 25, 1969. the following biochemical characteristics: aerobic glycolysisi respiration, glucose- 6-phosphate-dehydrogenase activity, A 11013 the Crabtree effect; increase in the Sequeire, L. level of glycolyele in vitro and in SYNTHESIS OF SCOPOLIN AND SCOPOLETIN IN vivo in the presence ofFT5Ienous TOBACCO PLANTS INFECTED BY PSEUDOMONAS ITUFose; free animated acids in the SOLANACEARUM. Phytopatholugy 59(6): liver. Similarly, the hiatopathologic 473.8, Apr 1969. changes were followed up to the

26 A 11027 (continued) A11023 (continued) appearance of the formed tumors.The IN VITRO XHIMICHESKIMI KANTSEROCIENAMI I results obtained plead for the classing VIOnET. I. Otsutsviye Sinergisma Fri of the liver tumors obtained in the group Sovmestnom Deystvii Kantserogenov I of minimal deviation hepatomas (Morris Viruaa Poliomy. (MALIGNANT TRANSFORMA- hepatomas). (Author Abstract) TION OF CELLS IN VITRO BY CHEMICAL CARCINOGENS ANITVIRUSES. I. The Absence of Synergism at a Combined Action of A 11024 Carcinogens and Polyoma Virus.) Schmahl, D., Osswald, H., and Goerttler, K. Akademiia Nauk SSSR Tsitologlia 11(2): CANCEROGENE WIRKUNG VON DIATHYLNITROSAMIN 242-7, 1907-Kailin (Abs.F BEI SCHWEINEN. (CANCEROGENIC ACTIVITY OF DIETHYLNITROSAMINE IN PIGS.) A combined action of such chemical Zeitschrift fur Krebsforschun 72(1): carcinogens as 7,12-dimethyldibenz- 102=4, 1969,-Vrman A s. anthracene (DMBA), 3,4-benzo(a)pyren (BP), urethan, nitrosoethylurea, nirro- Diethylnitrosamine was given orally somethylurea, and polyoma virus on to two pigs in daily dosages of 1.5-3.0 normal rat's and golden hamster's mono- mg/kg. 470 resp. 594 days after beginning layer embryo cells (mass culture) is of treatment the animals were killed and investigated. All the above chemical showed severe hepatic cirrhosis and agents were not found to increase the hepatomas. In one case an adenoma of a transformation frequency of normal kidney was found additionally. (Author tissues by the polyoma virus.Ater 72 Abstract) hours' treatment of a primary hamster tissue with DMBA in the dose of 0.005 mg per ml, a culture of cells able to live A 11025 in vitro was obtained. Ow analyzing the Kunte, H. 'Clones of the culture characteristic UNTERSUCHUNGEN ZUR HEMMUNG DER BENZPYREN- signs of loss of the contact inhibition HYDROXYLIERUNG DURCH VERSCHIEDENE POLY- of movement were recorded. In the animal CYCLISCHE, AROMATISCHE KOHLENWASSERSTOFFE. inoculated with the DMBA treated culture, (STUDIES OF THE INHIBITION OF BENZPYRENE that had been growing in vitro for 105 HYDROXYLATION BY VARIOUS POLYCYCLIC days, no tumors developedXFter AROMATIC HYDROCARBONS.)Zeitschrift infecting the DMBA treated culture by fur Krebsforschung 72(1):57-62, 1961, polyoma virus, morphologically trans- N7man (Abs.) formed clones were obtained and the following examination for oncogenic It was shown in in vitro experiments properties gave positive results.For with mouse-liver-microsomes that the control tumor study, cells were derived hydroxylation of benzo(a)pyrene is from 1st to 4th passages. These cells inhibited by fluoranthene, pyrene, benz(a) failed to give rise to tumors. (Author anthracene, and phenol. With a benzo- Abstract) pyrene-concentration of 1.3 X 10 to the minus 5 M, the inhibition by one of the 3 hydrocarbons amounts to 20-30 percent if A 11030 the concentration is equal. With a 5-fold Laville, Cl. and Margarit, J. amount there is 30-60 percent and with a SUR LES EFFETS NEUROLOGIWES 10-fold amount 60-93 percent inhibition. CENTRAUX DU SULPIRIDE. (CENTRAL Phenol in a concentration of 3 X 10 to NEUROLOGIC EFFECTS OF SULPIRIDE.) the minus 3 M, has an effect of only 65 Pathologi Biologie 17(1-2):71-5, Jan percent. The possibility is discussed, 1959, French (Abs.) that noncarcinogenic aromatic hydrocarbon in this way may be able to influence With regard to pharmacological agents carcinogenesis by environmental factors, designed to demonstrate some effect on since relations in concentration as used theC.N.S., e.g. mescaline, tryptamine, in the experiments occur in water, dust morphine, tremorine, nicotine, amphet- and food. (Author Abstract) amine or serotonin, sulpiride is usually inactive. In the mouse, there are no anticonvulsant effects. (Author Abstract) A 11027 Parkornenk:, II, Ir lin, I. S. and Konovalova, N. P. A 11031 Chiancone, F. M. 3TOKA4ECTBO-ttAA TPAHC.00TI.Aitlq KJETCX i1 vITRO IL METABOLISM° TRIPTOFAW--ACIDO 44444ECKAti KAMEPCCIEKAKI H 84CYCAAL 10TOICTBNE Off ini31A 1 P.1cotrecnoi ariciasi NICOTINIC° NEILS MALATTIE PSICHIATRICHE. (TRYPTOPHAN - NICOTINIC ACID METABOLISM orsteoroloeN BVIPYCAncoicru. IN PSYCHIATRIC DISEASES.) Acta ZLOKACHESTVENNAYA TRANSFORMATSIYA KLETOK Viteminologica It Enzymologra-22(3-4)i

27 A 11031 (continued) A 11033 (continued) 111-33, 1968, Italian (Abs.) OF THE PELLAGRA PROBLEM.) Acta Vitaminologica et Enzymologra22(3-4): The availability of relatively simple 90-7, 1968, Italian (Abs.) analytical methods and the results of preliminary studies on the presence of The pellagra problem still presents tryptophan metabolism alterations in social, medical and biological aspects several diseases, inducing pone of which await solution and must therefore Psychiatric interest have been the two be pointed out and discussed. One of basic reasons for development of research these aspects concerns the diffusion of in this field during the last decade. the disease, which is not localized Moreover, the importance for the central merely in countries or populations whose nervous system of at least one metabolite diet is based on maize. In fact, besides of the amino acid - serotonine - was pre- the formdue to dietetic deficiencies viously known; observations on the use of there is also a form of pellagra due to tryptophan in psychiatric therapy are metabolic errors and one due to drugs, recent. These considerations have led to i.e. of iatrogenic nature. 'Primitive" examine the data available on tryptophan- forms (for instance, Hartnup's syndrome) nicotinic acid metabolism in psychiatric and "secondary" forms (for instance, diseases and the possible outlooks of oellegra of alcoholics) can be distingu- future studies in this field. Said ished in pellagra due to metabolic errora. metabolism has been studied through Individual factors may be of importance elimination 0;7 Lhe main metabolites in also in the pathogenesis of pellagra due the urine after a dose of the amino-acid to dietetic deficiencies, either due to and also independently from any load poor utilization of anti-pellagrous (spontaneous elimination). The results factors (comprising tryptophan and obtained in the following diseases are methionine to which Caletti draws atten- examined* schizophrenia, mongolism tion) present in the diet, or to mental weakness and retardation. The metabolic disturbances leading to reduced information relative to other psychiatric endogenous synthesis of niacin. conditions is included, for the moment. in the group of "miscellaneous". A 11034 Mathieu-Levy, N. A 11032 CONTRIBUTION A L'ETUDE DU MECANISME DE Mainardi, L., Magni, L. A., and Careddu, P. LA POTEVTIALISATZON DU SOMMEIL EXPERI- LLIMINAZIONE URINARIA DI CHINURENINA E DI MENTAL PAh L'ACIDE ADENOSINE TRI- ALTRI METABOLITI DEL TRIPTOFANO PRIMA E pRogPHOR/QUE (ATP). SUR QUELQUES DOPO SOMMINISTRAZIONE DI ACTIONS D'ATP AU NIVEAU DU SYSTEME PREONISOLONE NEL NEONATO. (URINARY NERVEUX CENTRAL. (CONTRIBUTION TO THE ELIMINATION OF XINURENIN AND OTHER STUDY OF THE MECHANISM OF THE POTENTIA- TRYPTOPHAN METABOLITES IN THE NEONATE TION OF EXPERIMENTAL SLEEP BY ADENINE BEFORE AND AFTER ADMINISTRATION OF TRIPHOSPHATE (ATP). ON SEVERAL ACTIONS PREDNISOLONE.) Acta Vitaminologica et OF ATP ON THE CENTRAL NERVOUS SYSTEM.) Enumologica 22(3=i1r81-4, 1968, Therapie 23(0:1157-73, Sep -Oct 1968, Italian (Abs.) French (Abs.)

The influence of prednisolone (2 mg/kg A study of the influence of adenosine by intramuscular injection) on the triphosphate (ATP) on motor activity in urinary elimination of kynurenin, o-NH2- the mouse, analgesia in the rat and the hippuric acid and xanthurenic acid, has mouse (ATP without or together with two been studied in 12 new-born babies major analgesics), catalepsy in the rat, ranging from 1 to 13 days old. The basal induced convulsions in the rat and the Pattern of the same metabolites was also mouse. The effects of ATP at the level determined before treatment, in order to of the central nervous system are dis- obtain an exact reference term. The cussed. Small doses of ATP synergized results show that administration of the convulsant effects of nicotine in prednisolone had led only exceptionally mice. to an increase of the urinary kynurenin and A-N112-hippuric acid elimination; xantburenic acid was never encountered A 11037 (Author Abstract) Reckzeh, 0., Rucker, K., Harke, H.-P., and Dontenwill, W. UTIFASUCHUNGEN ZUR BESTIMMUNO DER A 11033 AXIITEN UND CHRONISCHEN TOXIZITAT VON Peinardi, L. and Bissanti, A. CIGARETTENRAUCH BEI PASSP/ER BERAUCHUNO ALCUNI ASPETTI ATTUALI DEL PROBLEMA VON VERSLICHSTIEREN. (INVESTIGATIONS OF DELLA PELLAGRA. SOME PRESENT ASPECTS THE DETERMINATION OF THE ACUTE AND 34 A 11037 (continued) A 11052 CHRONIC TOXICITY OF CIOARETTE SMOKE IN Friberg, L. PASSIVE SMOKING OP LABORATORY ANIMALS.) CIGARRETTER OCH REKLAM. (CIGARETTES AND Arzn imittel-Forschun19(2)1237-41, Feb ADVERTISING.) Lakartidningen 65(50 is , erman s.J 5012-3, Dec 11, 1968, Swedish (Aba.

Acute and chronic toxicity tests on The tar and nicotine content of Syrian hamsters, Wistar AF/Han rats, American cigarettes is briefly contrasted mice of the strains ICI and %%LB/ c-Jax with Swedish cigarettes.While an after passive exposure to tobacco smoke American cigarette may contain 6 mg tar are reported.The study intended to and 0.2 mg nicotine, the Swedish product find out the importance of nicotine and may have 14 mg tar and 0.8 mg nicotine. CO-content of the smoke for toxicity in The greatest difference was encountered general, and likewise for the development with Benson and Hedges which la a com- of body weight and food consumption for pletely different cigarette for Sweden. the test animals. (Author Abstract). The American manufacturer sells Sweden a product which is illegal in the United States. This also app).lea to cigarettes A 11050 protected by registered trademarks. Fleischhacker, M. and Cudina, Z. The contrast is pointed out, when dis- PROFES/ONALNE ALEROIJSKE EOLESTI cussing United States cigarettes, between RESPIRATORNIH OROANA. (OCCUPATIONAL required legends likes "caution', ALLERGIC DISEASES OF THE RESPIRATORY "cigarette smoking may be hazardous to ORGANS.i Amin Bolnice 'Dr. M. Stojan- your health', and advertising slogans °vie' 7 Sul-SW18)143-55, 1968, Serbo- like, "Your cigarette isn't lowest in tar UFFErion (Abs.) unless it's lower than Carlton," It satisfies longer", The taste is soft." Medical opinion is discussed on This is especially confusing to the allergic diseases of the respiratory Swedish importer who does not know that organs, for which pertinent statistical the legal restrictions for advertising and graphical data are included. Aller- and the required legends are different in gens act differently in humans; they Sweden and the United States. might be eliminated in normal body metabolism, may cause a specific reaction, lead to the formation of antibodies, or A 11059 may show a reaction unrelated to known Cederlof, R. and Edfors, M-L. Pharmacological and toxicological proper- HUR MYCKET TJARA OCH NIKOTIN INNEHALLER ties of the allergen. Specificity of CIOARRETTERNA? (WHAT IS THE TAR AND allergen is diagnosed with difficulty. NICOTINE CONTENT OF CIGARETTES?) Examination includes!anamnesis, complete Lakartidningen 65(50)15003-11, Dec 11, physical exam with otorhinolaryngology, 'Ate, Swedish (Abs.) cardiogram, and usually X-rays. The working environment of the patient should Over a 16-month period, 480 cigar- be inspected by the physician, if ettes from six different types were sam- possible.Statistics indicate that aller- pled and analyzed according to CORESTA gic diseases are frequently accompanied (European Tobacco Research Association) by non-allergic ones. The allergens may methods involving smoking the cigarettes be derived from certain portions of a in smoking machines.The tars were plant, such as the department in which burnt and the water arising this way feathers or molds are handled, and worker was determined by the help of the Karl may react from 0 to +4 to the same Fischer reagent.The nicotine was allergen.The type of work has an determined spectrophotometrically influence since a textile worker handling according to Willits al. Control feathers may show a completely different analyses were made by-thrTobacco incidence of allergic diseases than a Research Association and three sigma ceramicist or graphic artist handling the limits of analytical error were establish. same allergen. Remedial procedures (e.g., ed. Tabular results show the comparison proper ventilation) may prevent or reduce between Swedish cigarettes and cigarettes allergy outbreaks.Other procedures are from other countries, particular atten- specific! a room in which mold spores tion being paid to length and filter are present may be treated with super- materials present, if any. It can be heated steam. More than 50 percent of all seen that from 35 cigarette brands patients showed allergy to house dust and analyzed, the values are only occasion- their condition could be alleviated if ally beneficially affected by the residences are kept meticulously free presence of a filter. The filter from dust by electrostatic air filters might even actually account for increased or similar devices. values in tars andj,w nicotine.

29 33 A 11061 A 11071 (continued) Tobacco. ABERRATIONS IN HEMATOPOIETIC CELLS OP RESEARCH SCIENTIST CLAIMS ,IESS HAZARDOUS MICE. Oa_ nn 60(1):91-5, Feb 1969. CIGARETTE.' Tobacco 168(18):9, 17, May 2, 1969. A 11073 Tomatis, L. and Goodall, C. M. A 11063 THE OCCURRENCE OF TUMOURS IN Fl, Forehand, J. B., Badgett, C. E., and F2, AND F3 DESCENDANTS OF PREGNANT Rearik, F. E. MICE INJECTED WITH 7,12-DIMETHYLBENZ AUTOMATED DETERMINATION OF CALCIUM IN (a)ANTHRACENE. International TOBACCO USING GLYOXAL-BLS (2-HYDROXMIL). gurna1 of Cancer !12):219-25, Mar 15, Tobacco 168(18):22 -4, May 2, 1969. !TM

A 11064 A 11075 Leach, J. T., Alford, E. D., and Litzinger, Opler, S. R. E. 7. TRANSMISSION OF VIRAL INDUCED CAVIAN 4-VINYLCATECHOL IN CIGARETTE SMOKE. LEUKEMIA BY THE ORAL ROUTE. Oncology Tobacco 168(18):25, May 2, 1969. 22(4)1273-80, 1968.

A 11065 A 11076 Kuntzman, R. Schlesinger, M., Orossowicz, N., ana DRUGS AND ENZYME INDUCTION. Annual Lichtenstein, N. Review of Pharmacology 9121-3tr19. ANTI-TUMOUR ACTIVITY OF CARI3OBENZOXY- L-ASPARAGINE. Experientia 25(1):14-5, Jan 15, 1969. A 11066 Brown, D. A., Hoffmann, P. C., and Roth, L. J. A 11077 3H-NICOT1NE IN CAT SUPERIOR CERVICAL AND Parry, E. W. NODOSE GANGLIA AFTER CLOSE-ARTERIAL A QUANTITATIVE METHOD FCR ASSESSMENT INJECTION IN VIVO,British Journal of OF HEPATOCELLUIAR LYSOSOKES--ITS PharmacologY3511):4WIT711. APPLICATION TO NORMAL AND TUMOUR- BEARING ANIMALS. Journal of Patholory,97(1)115547-7FhT969. A 11067 Charles, J. L., Stahr, H. M., and Ikeda, R. M. A 11079 AUTOMATED DETERMINATION OF NICOTINE IN Platt, D. S. and Cockrill, B. L. TOTAL PARTICULATE MATTER OF CIGARETTE BIOCHEMICAL CHANGES IN RAT LIVER IN SMOKE. Tobacco 168(19)t22 -6, May 9, 1969. RESPONSE TO TREATMENT WITH DRUGS AND OTHER AGENTS--/I.Effects of Halothane, DDT, other Chlorinated Hydrocarbons, A 11068 Thioaceta,Ade, Dimethylnitrosamine and Chen, T. T. and Heidelberger, C. Ethignine. Biochemical Pharmacology QUANTITATIVE STUDIES ON THE MALIGNANT 18(2):445-57, Feo 1969. TRANSFCRMATION OF MOUSE PROSTATE CELLS BY CARCINOGENIC HYDROCARBONS IN VITRO. International Journal of CanciFI/717166- A 11080 117,577137-79677---- Lang, W. J. and Rush, M. A COMPARISON OP CONDITIONAL RESPONSES INDUCED BY VARIOUS DRUGS. British A 11069 Journal of Pharmacology 35(2/13EET. Lausch, R. N. and Rapp, P. Fe-r959. CONCOMITANT IMMUNITY IN HAMSTERS BEARING DMBA-INDUCED TUMOR TRANSPLANTS. International Journal of Cancer 4(2):226- A 11082 31', Mar 15, 196117 Bennett, A. end Fleshier, B. ACTION OF PROSTAGLANDIN EI ON THE LONGITUDINAL MUSCLE OF THE GUINEA-PIG A 11071 ISOLATED COLON, British Journal of :Writs, Y., Shisa, H., Matsuyama, M., :harmaco1ogy 55(21735115:2157-7771169. Nithizuka, Y., Tsuruta. R., and Yosida, T. H. CARCINOGEN- INDUCED CHROMOSOME

34 A 11084 A 11134 Becker, E. J. and Kreuzer, F. Klaiber, M. S., Oruenstein, M., Meranze, D. SYMPATHOADRENAL RESPONSE TO EYPDXIA. R., and Shimkinj M. B. Pflygers Archly European Journal of INFLUENCE OF HYPOTHALAMIC LESIONS ON THE T'VsTarDgy 304i1):1"..10, INDUCTION AND GROWTH OF MAMMARY CANCERS IN SPRAOUE-DAWLEY RATS RECEIVING 7,12- DIMETHYLBENZ(a)ANTHRACENE.Cancer A 11085 Research 29(57:999-1001, May 1969. Kershbaumj A., Osada, H., Pappajohn, D. J., and Bellet, S. EFFECT OF NICOTINE ON THE MOBILIZATION A 11135 OF FREE FATTY ACIDS FROM ADIPOSE Veasslinovitch, S. D. TISSUE IN VITRO.Experientia 25(2)1 THE SEX- DEPENDENT DIFFERENCE IN THE 128, Feb 1-67-1-46s. DEVELOPMENT OF LIVER TUMORS IN MICE ADMINISTERED DIMETHYLNITROSAMINE. Cancer Research 29(5):1024-7, May 1969. A 11097 Baldwin, R. W., Barker, C. R., and Moore, M. A 11136 DISTRIBUTION OF A BASIC AZO-DYE- Sugiyama, T., Kuritaj Y., and Nishizuka, Y. BINDING PROTEIN IN NORMAL RAT TISSUES BIOLOGIC STUDIES ON 7,12-DIMETHYLBENZ(a)- AND CARCINOGEN-INDUCED HE ?ATOMATA. ANTHRAOENE-INDUCED RAT LEUKEMIA WITH British Journal of Cancer 22(4)1776-86, SPECIAL RTYERENCE TO THE SPECIFIC Dec 1958. CHROMOSOMAL ABNORMALITIES. Cancer Research 29(5):1117-21, May 196fr

A 11099 Carter, R. L., Percival, W. H. and Roe, A 11137 F. J. C. Oraham, J. O. and Oppenheimer, D. R. EXCEPTIONAL SENSITIVITY OF MINK TO THE ORTHOSTATIC HYPOTENSION AND NICOTINE HEPATOTOXIC EFFECTS OF DIMETHYLNITRO- SENSITIVITY IN A CASE OF MULTIPLE SYSTEM SAMINE. Journal of Pathology 97(1): ATROPHY. Journal of Ne 108Y, Neuro- 79-88, JanrggW7 a e aridPW7ERGEry 8-T47Feb

A 11102 Conneyj A. H. A 11139 DRUG METABOLISM AND THERAPEUTICS. Hilf, R., Goldenberg, H., Michel, New E land Journal of Medicine 280(12): Carrington, M. J., Bell, C.Gruensteir4 533- , 20, 19697 M., Merame, D. R., and ShAin, M. B. BIOCHEMICAL CHARACTERISTICS OF MAMMY GLANDS AND MAMMARY TUMORS OF RATS NDUCED A 11114 BY 3-METHYLCHOLANTHRENE kND 7,12-DiMETHYL- Wood, M. BENT)ANTERACENE. Canes Research AETIOLOGY OF TUMOURS OF THE URINARY 29(5 1977-88, May 19 . BLADDER. Pathologic 11 ricrobloloAla 32(4):177-90, 1968. A 11148 Tjalve, H., Hanseon, E., and Schmiterlow, A 11125 C. O. Food and Cosmetics Toxicology. PASSAGE OF 14C-NICOTINE AND ITS METABOLITES NITROSOAMINES: A JIO-SAW PUZZLE WITH INTO MICE FOETUSES AND PLACENTAE.Acta MISSING PIECES.Ecod an4 Cosmetics Pharmacologica 4t ToxicolOgica 26(6)7-- Toxicology 6(5)1647;5-3-117117-- 339-55, 1968.

A 11130 A 11149 Oross, P., Pfitzer, E. A., Watson, J. Misiewicz, J. J., Waller, S. L., Anthony, DeTreville, R. T. P., Kaachak, M., Tolker, P. P., and 04mmer, J. W. P. E. B., and Babyakj M. A. ACEALASIA OF THE CARDIAi PHARMACOLOGY EXPERIMEMTAL CARCINOOENESIS.Bronchial AND HISTOPATHOLCOY OF ISOLATED CARDIAC Intramural Adenocaroinomas in Rats From SFEINCTERIC MUSCLE FROM PA'IENTS WITH X-ray Irradiation of the chest. Cancer AND WITHOUT ACHALASIA.gartlirlY 23(5)11046-60, May 1969. Journal of Medicine 38(ligji77-3415, Jan 1959.

35 A 11152 A 31164 (continued) Korotkova, 0. P. and Tokin, B. P. Athens, Greece, Sep 19 -26, 1966, pp. STIMULATION OF THE PROCESS OF SOMATIC 57-63, French (Abs.) EMBRYOOENESIS IN SOME PORIFERA AND COELENTERATA. I. Effect of Cancerogenic A new series of tests begun in 1965 Agents on Some Porifera.Acta Bielogica on watering tobacco crops and plastic Acadmitse SolentiarumHungraFae 19(s): mulching. This experimentation consisted 465-71, 1968. of 6 comparisons: 1--Te: unwatered, non. mulched plots. 2 - -As watered, non- mulched plots. 3 - -Ps unwatered, mulched A 11153 plots. 4--PA: mulched and watered plots. Carrillo, L. and Aviado, D. M. 5--Ppt mulched, unwatered plots, early MONOCROTALINE-INDUCED PULMONARY harvested. 6--PApt mulched, watered HYPERTENSION AND 2-CHLOROPHENYLAIANINE plots, early harvested. First results (PCPA). Laboratory Investigation 20(3): confirm and complete previous findings: 243-8, Mar 1969. Watering in relatively dry years (4 waterings of 20 mm) increased yield by about 18-20 percent. The tobacco pro- A 11156 duced was riper, better colored and Clayson, D. B., Pringle, J. A. S., had lower nitrogen and alkaloid contents; Bonser, 0. M., and Wood, M. the filling capacity of cut tobacco was THE TECHNIQUE OF BLADDER considerably improved. Plastic mulching IMPLANTATION: FURTHER RESULTS AND induced more rapid plant growth and AN ASSESSMENT. British Journal earlier maturity (lighter tobacco with of Cancer 22(4):825-32, Dec 1968. less nitrogen).However, the effect of this treatment on yield and on filling capacity of cut tobacco was, for the first A 11161 year, not very substantial. On mulched Coresta and the National Tobacco Board of plots, the harvesting date having been Greece. brought forward by about 15 days, yields PROCEEDINGS OF THE FOURTH INTERNATIONAL were appreciably lowered.This decrease TOBACCO SCIENTIFIC CONGRESS.The was higher for nonwatered plots ( - -20 National Tobacco Board of Greece, Athens, percent) than for watered plots --12 Greece, Sep 19-26, 1966, 1128 pp. percent). (Author Abstract).

A 11162 A 11165 Chouteau, J. knit's,' N. and loan, E. MINERAL NUTRITION AND FERTILIZATION OF L'INFLUENCE DE LA NUTRITION MINERALE TOBACCO. In Proceedings of the Fourth ET DE L'EAU DU SOL SUR L'HETEROSIS DU International Tobacco Scientific Congress. TABAC. (THE INFLUENCE OF MINERAL The National Tobacco Board of Oreece, NUTRITION AND SOIL WATER ON TOBACCO Athens, Greece, Sep 19-26, 1966, pp. 30-3. HETEROSIS.) In Proceedings of the Fourth International Tobacco Scientific Congress. The National Tobacco Board of A 11163 Greece, Athens, Greece, Sep 19-26, 1966, Arghyroudia, D., Binopoulos, X., Kavasis, pp. 83-95, French (Abs.) 0., and Sficas, A. 0. THE EFFECT OF SOME GREEN MANURING The Fl hybrid (Res. Hicks X line 128- PRACTICES ON THE YIELD AND THE CHEMICAL 60 B) grown in pots, gave higher yields COMPOSITION OF ORIENTAL TOBACCO. Int than its parents, in the different vari- Proceedings of the Fourth International ants of water and nitrogen in the soil. Tobacco Scientific Congress. The National Nitrogen from the soil was better utilised Tobacco Board of Greece, Athens, Greece, by the hybrid whose chemical composition Sep 19-26, 1966, pp. 47-56. gave good quality leaf tobacco.Three categories of constituents of the fresh leaves at technical maturity stages glu- A 11164 cides, organic acids and free amino acids, Chouteau, J., Renier, A., and Loche, J. were determined by paper chromatography. INCIDENCE DES ARROSAGES ET DU PAIL1AOE In all variants of the trials, sucrose, PLASTIQUE DU SOL SUR CERTAINES glucose and fructose were found in the CARACTERISTIQVES PHYSIQUES ET CHIMIQUES leaf. Their level increased with DES TABACS. (THE EFFECT OF WATERING increasing amounts of water and N in the AND PLASTIC MULCHING ON CERTAIN PHYSICAL soil. There were positive correlations AND CHEMICAL CHARACTERISTICS OF TOBACCO.) between levels of malic, ,Itric, succinic In Proceedings of the Fourth Inter- and phosphoglyceric acids in the leaf and national Tobacco Scientific Congress. levels of N and water in the soil.Such The National Tobacco Board of Greece, correlations were less evident for tar-

32 A 11165 (continued) A 11168 (continued) taric, alpha-ketoglutaric and fumaric sequently, there is no connection, in this acids. The total quantity of free amino case, between leaf browning intensity and acids of the green leaves increased with its water soluble brown pigment content. increasing amounts of N in the soil for 2 Research being carried out, suggests that water levels tested. Quantitative and in air-oured tobaccos, the products of qualitative variations were thus found in breakdown of plastid pigments have a the free amino acids in tobacco under considerable influence on the color pf these experimental conditions. (Author the cured tobacco. (Author Abstract) Abstract) A 11169 A 11166 Dimitrijevio, R., Derain, A., Nikacevic, M., Massantini, F. and Favilli, R. and Mitic, D. THE EFFECTIVENESS OF VARIOUS FORMS OF LA DYNAMIQUE DE QUELQVES COMPOSANTS NITROGEN IN THE PRODUCTION, QUALITY AND ORGANIQUES AU COURS DE LA VEGETATION DU NICOTINE CONTENT OF TOBACCO. Int TABAC. (THE DYNAMICS OF SOME ORGANIC Proceedings of the Fourth International CONSTITUENTS DURING TOBACCO GROWTH.) Tobacco Scientific Congress.The National Ins Proceedings of the Fourth Internation- Tobacco Board of Greece, Athens, Greece, al Tobacco Scientific Congress. The Sep 19-26, 1966, pp. 96-107. National Tobacco Board of Greece, Athens, Greece, Sep 19-26, 1966, pp. 162-71, French (Abs.) A 11167 Schipfer, L. A certain number of works dealing with INFLUENCE OF INCREASE N-FERTILIZATION ON the problem of the dynamics of organic THE CONTENT OF NITROGEN AND NICOTINE OF matter during growth are found in scient- BURLEY-SEMFERANTE. In: Proceedings of ific literature. The majority of these the Fourth International Tobacco Scientif- works deal with this problem in large ic Congress.The National Tobacco Board leafed tobacco; there is little informa- of Greece, Athens, Greece, Sep 19-26, 1966, tion to be found for small leafed, pp. 115-8. Oriental tobacco. For this reason, we decided to study, in a series of trials, the dynamics of total dry matter as well A 11168 as the reducing substances, total nitro- Chouteau, J. and Alpo, J. P. gen, Protein nitrogen and nicotine, PIGMENTATION DU TABAC SEC EN FONCTION considering them as the most important DE LIALIMENTATION AZOTEE ET POTASSIQUE constituents of tobacco quality. After DE LA PLANTE. ROLE DES POLYPHENOLS. three years of trials, we conclude that (THE PIGMENTATION OF CURED TOBACCO AS A it is possible to obtain a fairly large FUNCTION OF THE SUPPLY OF NITROGEN AND Quantity of good quality tobacco by POTASSIUM TO THE PLANT. THE ROLE OP THE applying adequate measures during growth, POLY PHENOLS.) Ins Proceedings of the and by knowing the dynamics of the Fourth International Tobacco Scientific accumulation and translocation of organic Congress. The National Tobacco Board matter for each stalk position of the of Greece, Athens, Greece, Sep 19-26, leaves. (Author Abstract) 1966, pp. 142-8, French (Abs.)

Pot experiments showed that after air- A 11170 curing the leaves of Paraguay type tobacco Iljin, G. S. are darker as nitrogen supply is heavier BIOCHEMISTRY OF TOBACCO ALKALOIDS. In' and as potassium supply is lighter. Proceedings of the Fourth Intrnational Analyses carried out before and after Tobacco Scientific Congress. The National curing show that this phenomenon cannot Tobacco Board of Greece, Athens, Greece, be explained by variations in the Sep 19-26, 1966, pp. 172-7. polyphenol levels, since chlorogenic acid and free rutin are found in the green leaf in quantities which decrease A 11171 as the amount of nitrogen the plant Matusiewicz, E. received increased. A brown pigment PHOSPHORUS AND NITROGEN INFLUENCE ON THE soluble in buffer at pH 7 and non-dialyz- DEVELOPMENT OF CROP TOBACCO AND ON SOME able, was isolated in cured leaves follow- CHARACTERISTICS OF LEAVES. Ins Proceed- ing techniques used by Jacobson (1961). ings of the Fourth International Tobacco The results of hydrolysis confirm that Scientific Congress, The National this pigment is a combination of iron - Tobacco Soard of Greece, Athens, Greece, protein - polyphenols. It is more colored Sep 19-26, 1966, pp. 178-83. and more concentrated in evred tobacco as the green leaf is richer in chlorogenic acid, therefore poorer in nitrogen. Con- 3933 A 11172 A 11176 (continued) Popov, M. D. tional Tobewco Scientific Congress.The EFFECT OF MALEIC HYDRA2IDE (MH) ON THE National Tobacco Board of Greece, Athens, SUCKERS, INFLORESCENCE AND QUALITY OF Greece, Sep 19-26, 1966, pp. 326-33, ORIENTAL TOBACCO. In! Proceedings of French (Abs.) the Fourth International Tobacco Scientific Congress. The National Tobacco Board of The curing of Oriental tobacco under a Greece, Athens, Greece, Sep 19-26, 1966, polyethylene film compared to direct cur- pp. 283-9. ing in the sun, reduced the time required for curing per priming by about 4 to 8 days, improved the color, increased the A 11173 weight of tobacco and its equilibrium Johnson, W. H. moisture content, improved its consiatency INFLUENCE OF HARVESTING PROCEDURES AND and hygroscopic power, increased the per- CURING VARIABLES ON CHARACTERISTICS OF centage of superior qualities, reduced .VIRGINIA-TYPE TOBACCO. In: Proceedings the total N and nicotine contents, of the Fourth International Tobacco Scient- increased the amount of reducing augers, ific Congress. The National Tobacco and improved the smoking qualities. The Board of Greece, Athens, Greece, Sep 19-26, degree of improvement depends especially 1966, pp. 300-15. on variety, the priming, climatic conditions (r.h. and dews), the nature of the ground and cultural methods.Generally A 11174 speaking, results obtained in Lebanon Carvgno, N. and Fedrizzi, L. show that qualitative differences are RSCHERCHES SUR CERTAINS CARACTERES DU more marked, as the priming is of higher TABAC TYPE VIROINIE SECHE SUIVANT LA stalk position, as the r.h. of the air is METHODE DU "BULK- CURING" PAR RAPPORT AU higher, and as the dews are more abundant. SECHAGE TRADITIONNEL. (INVESTIGATIONS (Author Abstract) ON SOME CHARACTERISTICS OF VIRGINIA TOBACCO LEAF AFTER BULK-CURING AS COMPARED TO THOSE AFTER FLUE-CURING.) A 11177 In: Proceedings of the Fourth Inter- Hitler, H., Mounat, A., Chouteau, J., national Tobacco Scientific Congress. Catamajour, F., and Albo, J. P. The National Tobacco Board of Greece, ESSAIS DE SECHAGE DE TABACS BRUNS PAR Athens, Greece, Sep 19-26, 1966, pp. "BULK CURING". (TESTS ON CURING DARK 316-22, French (Abs.) TOBACCO BY BULK CURING.) Ins Proceedings of the Fourth International Tobacco Some chemical (nicotine content, Scientific Congress. The National Tobacco sugars) and physical (sorption - desorp- Board of Greece, Athens, Greece, Sep 19- tion, filling power, weight per surface 26, 1966, pp. 342-9, French (Abs.) unit) characters as well as the burning After prelimine.,/ trials, a comparison quality of flue-cured and bulk-cured was made in 1965, between the conventional tobaccos are examined.The data evidence method of curing dark tobacco and that of that, while the look of tobacco differs, bulk curing, under the double aspect of according to its type of curing, the technique and economy. Bulk curing which characteristIcs investigated do not show is quicker, enabled six loadings of tob- significant differences. (Author Abstract) acco to be cured successively in one season in the same curing unit. In fact, A 11175 only the first batch underwent the whole Ttimaki, E. and Noguchi, M. treatment under artificial conditions, CHEMICAL STUDIES ON NITROGENOUS COMPOUNDS the five others were cured by a mixed IN TOBACCO LEAVES DURING FLUE-CURING. method, the first stage being carried out In Proceedings of the Fourth Inter- in the open air. Each time, similar national Tobacco Scientific Congress. batches, harvested on the same day, were The National Tobacco Board of Greece, air-cured. In both cases the plants were Athens, Greece, Sep 19-26, 1966, pp. 325 -7. stalk harvested. In spite of some damage due to a defect in coordinating the various harvesting stages, the experiment A 11176 showed that curing dark tobaccos by bulk Basile, E. and Fardy, A. curing is technically possible.However, EFFETS DU SECHAOE ACTIVE SOUS FILM DE the products obtained are generally less POLYETHYLENE SUR LES QUALTIES DU TABAC appreciated than those air-cured (the D' ORIENT, CULTIVE AU LIBAN. (THE tissue is often flattened, more friable, EFFECTS OF ACTIVATED CURING UNDER A coloring is mottled, ribs of a lighter POLYETHYLENE AID: ON THE QUALITY OF color, etc). During the drying process ORIENTAL TOBACCO GROWN TN LEBANON.) in bulk curing, the leaves lose less dry In Prcceedings of the Fourth Interns.-

36 sa A 11177 (continued) A 11179 (continued) matter; however, any advantage which results of the chemical analyses, the might result is to a large extent wiped content of total nitrogen and albumins out by the fact that the apparent density steadily increased while the soluble sugars of cut tobacco ls increased. Other and polyphenols decreased, in the mosaic- characteristics, such as nicotine levels affected tobacco leaves compared to and coMbuslblllty are little changed. healthy plants. These changes in the From an economic point of view, bulk chemical composition show up the detri- curing facilitates the use of more expedi- mental effect on the quality of tobacco tive work methods, resulting in important leaves. The nicotine content in the green labor savings. However, as things are at mosaic- affected tobacco leaves is a little Present, the running costs and additional higher compared to healthy plants. How- Paying of expenses) are much higher then ever, it is slightly less in the cured the savings thus obtained, (Author leaves). In any case, the problem of the Abstract) changes of nicotine level in mosaic-affected tobacco leaves needs more investigation and will be the subject of further experi- A 11178 ments based on improved and precise methods Solari, V. S. of sampling. (Author Abstract) HARVEST AND CURING OF TOBACCO IN ARGENTINA. Ins Proceedings of the Fourth Inter- national Tobacco Scientific Congress. A 11180 The National Tobacco Board of Greece, Schuster, O. Athens, Greece, Sep 19-26, 1966, pp. 357- INVESTIGATIONS INTO THE CAUSES OF 70. VIRUS-INDUCED VARIATIONS IN THE ALKALOID CONTENT OF THE LEAVES OF VARIOUS NICOTIANA SPECIES. In A 11179 Proceedings of the Fourth Blagojevic, M. International Tobacco Scientific EFFET DE LA MOSAIQUE COMMUNE SUR LE Congress.The National Tobacco RENDEMENT ET LES MODIFICATIONS CHIMIQUES Board of Greece, Athens, Greece, CHEZ LE TABAC HERZEGOVINIEN INOCULE A Sep 19-26, 1966, pp. 487-92. DIVERS INTERVALLES APRES LA PLANTATION. (THE EFFECT OF COMMON MOSAIC ON THE YIELD AND CHEMICAL CHANGES IN HERZEGOVINIAN A 11181 TOBACCO INOCULATED AT VARIOUS INTERVALS Ozkan, N., Taller, E., and Ozyolcular, M. AFTER FLKNTINO.) In Proceedings of the ESSAIS D'HYBRIDATION INTERSPECIFIQUE ET Fourth International Tobacco Scientific INTERVARIETALE POUR L'OBTENSION DE Congress. The National Tobacco Board of CULT/VARS TURCS RESISTANT AU MILDIOU DU Greece, Athens, Greece, Sep 19-26, 1966, TABAC. (INTERSFECIFIC AND INTERVARIETAL PP. 454-60, French (Abs.) HYBRIDIZATION TRIALS TO OBTAIN TURKISH CULTIVARS RESISTANT TO TOBACCO BLUE MOLD.) In the present paper, the Author Ins Proceedings of the Fourth Inter- reports the results of a study concerning national Tobacco Scientific Congress. the effect of common tobacco mosaic virus The National Tobacco Board of Greece, (TMV) on the yield and chemical composi- Athens, Greece, Sep 19-26, 1966, pp. tion of the most widespread tobacco 662-8, French (Abs.) variety Ravnjak in Herzegovinla, with special reference to the time of inocula- In 1962 we began interspecific and tion. It was found that tobacco mosaic intervarietal hybridization trials to virus causes a serious reduction in tobacco obtain Turkish cultivars resistant to yield. The amount of injury is related di- tobacco blue mold.We used N. debney1 rectly to the age of the plants at time of as well as Various Australian and American infection. The younger the plant at time resistant lines as a source of resistance. of inoculation, the greater is the damage. To obtain the fertility of amphihaplold When compared with an untreated control hybrids, we used colchicine and plot, the decreases in yield were: 40.4 acenaphthene. Aa a result of backcroasing Percent, 39.1 percent, 36.5 percent, 24.3 experiments, we aucceded in obtaining percent and 7.1 percent when the plants fertile plants from all our cultivars. We were inoculated 0, 15, 30, 45 and 60 days are now breeding B3 from the Balikesir after transplanting respectively. It is variety and B2 from other cultivars for assumed that the extent of the damage the 1966 season. We Proceeded with back- depends on the rise and fall of the virus crossing es well as selling on inter- concentration in the infected tobacco and varietal hybrids.For 1966, we are of the symptoms induced by the virus breeding lines F2 and 1 91. Ohrwato- concentrations, and, at the same time, on graphic research has shown that there is their relationship with the growth stage no difference between the alkaloids of of tobacco. As can be seen from the Fl hybrids and their parents,P1 inter-

)5 39 A 11181 (continued) A 11185 varietal hybrids gave the following Weybrew, J. A., Woltz, W. G., and changed morphological characteristics: Johnson, W. H. fewer leaves, thicker tissue, increased CHANGES IN THE FREE AMINO ACIDS OF length and width of the leaves. This TOBACCO DURING CURING. In: increase is most evident among small- Proceedings of the Fourth Inter- leafed cultivars. Preliminary trials on national Tobacco Scientific Congress. the industrial characters of Fl hybrids The National Tobacco Board of Greece, have shown that it is possible to use Athens, Greece, Sep 19-26, 1966, these hybrids in the manufacture of pp. 766-72. cigarettes. However, they have not yet been eat to commercial use. (Author Abstract) A 11186 Neurath, G., Krull, A., Pirmann, B., and Wandrey, K. A 11182 VOLATILE BASES OF TOBACCO. Ins Corbaz, R. Proceedings of the Fourth Inter- PREMIERES EXPERIENCES AVEC UNE VARIETE national Tobacco Scientific RESISTANTE AU MILDIOU ET CULTIVEE EN Congress. The National Tobacco GRAND. (FIRST EXPERIMENTS WITH A BLUE Board of Greece, Athena, Greece, MOLD RESISTANT TOBACCO VARIETY GROWN ON Sep 19-26, 1966, pp. 773-8. AN INDUSTRIAL SCALE.) Ins Proceedings of the Fourth International Tobacco Scientific Congress. The National A 11187 Tobacco Board of Greece, Athens, Greece, Ivanov, N. and Ognyanov, I. Sep 19-26, 1966, pp. 703-6, French (Abs.) ON RESINS IN BULGARIAN ORIENTAL TOBACCOS. In: Proceedings of A description of the new variety Sota the Fourth International Tobacco 27 is given; it is a Burley type, resis- Scientific Congress.The National tant to Peronospora tabacina, to tobacco Tobacco Board of Greece, Athens, mosaic virus and not very susceptible to Greece, Sep 19-26, 1966, pp. necrotic Y virus (PVY-n). Details are 779-85. reported on yield, proportion in the different grades and chemical analyses. Thia variety cultivated on an industrial A 11188 scale allowed the suppression of the Tornio, Lj., Demin, A., and Urosevic, P. fungicidal treatments in the fields; this LA FERMENTATION DES TABACS ORIENTAUX EN means for 1965 savings equal to 7.4 per- PRESENCE DE QUANTITES REDUITES D'OXYGENE. cent of the gross returns.Uninjured in (FERMENTING ORIENTAL TOBACCO IN THE 1964, the variety was however slightly PRESENCE OF LESS AMOUNTS OF OXYGEN.) infected with blue mold at the end of In Proceedings of the Fourth Inter- the 1965 growth season. In consequenne national Tobacco Scientific Congress. obligatory survey of the tobacco fields The National Tobacco Board of Greece, remains. ( Author Abstract) Athens, Greece, Sep 19-26, 1966, pp. 790- 3, French (Abs.)

A 111e3 A aeries of teats was carried out in Edreva, A. an air conditioned chamber to study the INVESTIGATION ON THE CHLOROGENIC effect of different fermentation temp- ACID CONTENT IN TOBACCO AS CONNECTED erature and an atmosphere poorer in TO ITS RESISTANCE TO PERONOSPORA oxygen, on the physical and chemical TABACINA ADAM. Ins Proceedings characteristics of oriental tobacco. of the Fourth International Reduced s,pply of oxygen was obtained by Tobacco Scientific Congress. The pressing bales to obtain greater National Tobacco Board of Greece, compactness, or, by using polyvinyl in- Athens, Greece, Sep 19-26, 1966, stead of sacking as packing material. pp. 713-6. Oriental tobacco (Prilep and Yaka varieties) was fermented at temperatures of 35 and 40 degrees C. Part of the A 11184 samples were packed normally ( sacking) Neurath, O. and the others were packed in polyvinyl. TOBACCO PRODUCTS AND SMOKE. In The compactness of the samples varied Proceedings of the Fourth Inter- from 241 to 346 kg/cubic m. Results national Tobacco Scientific Congress. obtained showed that reduced oxygen The National Tobacco Board of supply during artificial fermentation of Greece, Athens, Greece, Sep 19-26, tobacco gives different results when com- 1966, pp. 743-60. pared to tobacco fermented under oxygen conditions. (Author Abstract)

110 A 11189 A 11190 (continued) Arsenyan, E., Paskaleva-Tomova, K., and methods.In this way we were able to Staley, St. study the relationship between chemical CONTRIBUTION A L'ETUDE DES PROCESSUS composition and physical characteristics D'OXYDATION LOBS DE LA FERMENTATION DES on one hand, and the moisture equilibrium TABACS ORIENTAUX. (A CONTRIBUTION TO THE of tobacco on the other. It was observed STUDY OF OXIDIZING PROCESSES DURING THE that the crystalloid and colloidal matter FERMENTATION OF ORIENTAL TOBACCO.) of tobacco had a direct influence on its Ins Proceedings of the Fourth Inter- water retention capacity. It is interest- national Tobacco Scientific Congress. ing to note that nicotine plays no part The National Tobacco Board of Greece, from this point of view, nor do mineral Athens, Greece, Sep 19-26, 1966, pp. 794- constituents. The tissue density (ex- 9, French (Abs.) pressed as weight per 100 square cm; of leaf web) also has a direct relationship Investigations were made to establish with absorption and retention capacities the basis of the oxidizing processes dur- of tobacco. Knowledge of the relation- ing seasc:ual and artificial fermentation ship between the hydrous characteristics of Oriental tobacco. Description of a of tobacco and relative humidity and the method to investigate the oxygen uptake factors determining this relationship, is of oriental tobacco in aqueous suspension, of great use to the tobacco industry. to which a preparation of oxidizing (Author Abstract) enzymes, isolated from the same tobacco was added. Using this method it was found that during the fermentation of A 11191 Oriental tobacco, with moisture contents Mostly, R. J., Fiore, J. V., and of from 11.5 to 7 percent, the oxygen Jacin, H. uptake of the aqueous suspension of fer- CHARACTERIZATION OF PECTIC SUB- mented tobacco was the same as that of STANCES IN TOBACCO STEMS. In: unfermented tobacco. The author dis- Proceedings of the Fourth Inter- covered that during the fermentation of national Tobacco Scientific Oriental tobacco there is no interaction Congress. The National Tobacco between the oxidizing enzymes and their Board of Greece, Athens, Greece, substrates, and that the oxidizing Sep 19-26, 1966, pp. 808-19. processes are of a chemical nature. (Author Abstract) A 11192 Van Duuren, B. L. A 11190 THE FLUORESCENCE OF TOBACCO COUMARINS, Tomic, Lf., Demin, A., and Urosevic, P. HYDROXYFLAVONES AND RELATED COMPOUNDS. INFLUENCE DE LA COMPOSITION CHIMIQUE ET In: Proceedings of the Fourth DES CARACTERES PHYSIQUES DU TABAC SUR International Tobacco Scientific SA CAPACITE D'ABSORPTION ET DE RETEN- Congress. The National Tobacco TION DE LIHUMIDITE. (THE INFLUENCE OF Board of Greece, Athens, ("Preece, THE CHEMICAL COMPOSITION AND PHYSICAL Sep 19-26, 166, pp. 820-3. CHARACTERISTICS OF TOBACCO ON ITS CAPACITY TO ABSORB AND RETAIN MOISTURE.) In: Proceedings of the Fourth Inter- A 11193 national Tobacco Scientific Congress. Ormandy, A. The National Tobacco Board of Greece, COMPOSITION CHIMIQUE DES TABACS DE LA Athens, Greece, Sep 19-26, 1966, VARIETE VIRGINIA GOLD A SECHES A LA pp. 800-7, French (Abs.) CHALEUR ET A L'AIR NATUREL. (CHEMICAL COMPOSITION OF FLUE-CURED AND NATURALLY The relationship between the relative CURED TOBAOCO OF THE VIRGINIA GOLD humidity of the air and the moisture A VARIETY.) In: Proceedings of the equilibrium of tobacco is of great Fourth International Tobacco Scientific importance when treating tobacco during Congress. The National Tobacco Board curing, fermentation, manufacture and of Greece, Athens, Greece, Sep 19-26, finally in storage. Knowledge of all 1966, pp. 824-8, French (Abs.) the elements and factors which influence this relationship is very useful to During the years 1961-1964 experiments industrial practices. In a series of were made with respect to the chemical tests and in different analyses and composition of flue-cured tobacco of the determinations, we studied the behavior Virginia Gold A variety (domestic large- of some tobacco varieties with reference leaved tobaccos). The quality of these to humidity. The varieties differed from tobaccos was compared with those of the each other genetically, by cultural variety Virginia Bright Leaf ;orig. practices, chemical composition ani curing Virginia tobacco).It was found that

17 41 A 22293 (continued) A 11196 (continued) with respect to quality of the cigarette The National Tobacco Board of Greece, tobacco, variety plays an important role Athens, Greece, Sep 19-26, 1966, pp. and, within the variety, the maturity 859-64, French (Abs.) stage of the leaves at harvest, chemical composition being also affected by the Aa the density of the tobacco bales curing technology.The leaves of the is higher, changes in the absolute variety Virginia Gold A, at an optimal moisture content of tobacco are less stage of maturity and when correctly marked, and its loss during fermentation cured, may also give good quality raw is lower. When the density of the tob- material for cigarettes. The technology acco bales is higher.moisture is better of stalk - harvesting and curing of Preserved during storage under natural domestic large-leaved tobacco plants was conditions. When tobacco la fermented also tested, because these often accum- at a lower density in the bales, raw ash ulate large quantities of nitrogenous and proteins show a higher relative substances. The results obtained showed increase.When the fermentation process a good applicability of this technology is carried out at lower density, tobacco in practice. (Author Abstract) loses its ability to absorb 02 from the air. Chemical changes in tobacco are more marked when the density of the A 11194 tobacco in the bales during fermentation Soliven, F. A. is lower. The decrease may be noted in THE CHEMICAL COMPOSITION OF nicotine, total nitrogen and carbo- CIGARETTES MADE IN THE PHILIPPINES. hydrates, especially in soluble sugars, Int Proceedings of the Fourth important in determining the quality of International Tobacco Scientific Oriental tobacco. Congress.The National Tobacco Board of Greece, Athens, Greece, Sep 19-26, 1966, pp. 838 -42. A 11197 Muller, R. and Moldenhauer, W. STUDIES ON THE INFLUENCE OF THE A 11195 LENGTH OF CIGARETTE FILTERS ON Patche, L., Petchiareski, 0., and Bocevski, THEIR EFFICIENCY FOR ADSORBING D. NICOTINE, ANHYDROUS SMOKE CONTRIBUTION A L'ETUDE DU PROBLEMS DE LA CONDENSATE AND PHENOLS. In QUALITE DU TABAC ORIENTAL EN RAPPORT Proceedings of the Fourth Inter- AVEC QUELQUES-UNS DES STONES EXTERIEURS national Tobacco Scientific Congress. DU TABAC EN FEUILLE. (A CONTRIBUTION TO The National Tobacco Board of THE STUDY OP ORIENTAL TOBACCO QUALITY IN Greece, Athens, Greece, Sep 19-26, RELATION TO SOME EXTERNAL FEATURES OF THE 1966, pp. 880-5. TOBACCO LEAP.) Int Proceedings of the Fourth International Tobacco Scientific Congress. The National Tobacco Board of A 11198 Greece, Athens, Greece, Sep 1926, 1966, Keith, C. H. and Mittenheimer, J. R. 847-52, French (Abs.) VAPOR FILTRATION BY FIBROUS CIGARETTE FILTERS. Int In order to discover how far, and in Proceedings of the Fourth Inter- What way, external features of leaf national Tobacco Scientific tobacco may be used to judge its commer- Congress. The National Tobacco cial quality, a certain number of leaves Board of Greece, Athens, Greece, classified according to features such as Sep 19-26, 1966, pp. 886-94. leaf dimension, color and thinness of leaf web were examined chemically and by tasting. The study was made on Oriental A 11199 tobacco (a Prilep possibly from the 1963 Moshy, R. J. and Lang, R. E. and 1964 Prilep harvests). SMOKE AND PHYSICAL STRUCTURE' CIGARS. Int Proceedings of the Fourth International Tobacco A 11196 Scientific Congress.The BoCevski, D. National Tobacco Board of Greece, INFLUENCE DE LA DENSITE DES BALLES SUR Athens, Greece, Sep 19-26, 1966, LES TRANSFORMATIONS DU TABAC D'ORIENT pp. 904-22. AL COORS DE SA FERMENTATION. (THE IMF:VENCE OP BALING DENSITY ON CHANGES IN ORIENTAL TOBACCO DURING FERMENTATION.) A 11200 Int Proceedings of the Fourth Inter- Tiggelbeck, D., Joyce, R. S., and national Tobacco Scientific Congress. Kranc, M. P. INCREASING SELECTIVE EFFICIENCY IN

36 42- A 11200 (continued) A 11206 -CIGARETTE FILTER CHARCOALS. In: Elmenhorst, H. Proceedings of the Fourth Inter- AUTOMATIC SMOKING MACHINE FOR THE national Tobacco Scientific LARGE SCALE PRODUCTION OF CIGARETTE Congress. The National Tobacco SMOKE CONDENSATE. In: Proceedings Board of Greece, Athens, Greece, of the Fourth International Tobacco Sep 19-26, 1966, pp. 923-44. Scientific Congress.The National Tobacco Board of Greece, Athens, Greece, Sep 19-26, 1966, Pp. 1029-39. A 11201 Kuhn, H. A COMPARATIVE STUDY OF CIGARETTE A 11207 AND CIGAR SMOKE. In: Proceedings Mokhanachev, I. 0., Popova, L. P., of the Fourth International Dolan, L. A., Sirotenko, A. A., Tobacco Scientific Congress.The Kamenstchikova, S. V., Kovtunov, V. S., National Tobacco Board of Greece, Latayeva, D. N., Pisklov, V. P., and Athens, Greece, Sep 19-26, 1966, Serdjuk, L. C. pp. 967-71. THE OAS PHASE OF SMOKE AND THE INFLUENCE OF THE NEUTRAL PART OF TOBACCO RESIN ON ITS COMPOSITION. A 11202 In: Proceedings of the Fourth Carugno. N. and Rossi, S. International Tobacco Scientific EVALUATION OF NORMAL, BRANCHED Congress. The National Tobacco PARAFFIN HYDROCARBONS AND SOME Board of Greece, Athens, Greece, UNSATURATED ALIPHATIC HYDROCARBONS Sep 19-26, 1966, pp. 1040-61. IN CIGARETTE SMOKE BY °LAW CAPILLARY COLUMNS. In: Proceedings of the Fourth Inter- A 11208 national Tobacco Scientific Congress. Mokhnachev, I. 0., Popova, L. P., The National Tobacco Board of Sirotenko, A. A., Dulan, L. A., Greece, Athens, Ureece, Sep 19-26, Kamenstchikova, S. V., Kovtunov, V. S., 19E6, pp. 972-8. Latayeva, D. N., Pisklov, V. P., Serdjuk, L. 0., and Ul'anov, A. V. INVESTIGATION OF THE PRODUCTS OF A 11203 TOBACCO RESIN PYROYLSIS. In: Pappas, N. A. and Binopoulos, X. E. Proceedings of the Fourth Inter- ISOLATION, IDENTIFICATION AND national Tobacco Scientific DETERMINATION OF POLYCYCLIC Congress. The National Tobacco AROMATIC HYDROCARBONS OF CIGARETTE Board of Greece, Athens, Greece, SMOKE CONDENSATE USING THE THIN LAYER Sep 19-26, 1966, pp. 1062-74. CHROMATOGRAPHIC TECHNIQUE. In: Proceedings of the Fourth Inter- national Tobacco Scientific Congress. A 11209 The National Tobacco Board of Robb, E. W., Johnson, W. R., Westbrook, Greece, Athens, Greece, Sep 19-26, J. J., and Seligman, R. B. 1966, pp. 979 -1002. MODEL PYROLYSIS-THE STUDY OF CELLULOSE. In: Proceedings of the Fourth International Tobacco A 11204 Scientific Congress. The National Neurath, 0., Dunger, M., Oewe, J., Board of Greece, Athens, Greece, Luttich, W., and Wichern, N. Sep 19-26, 1966, pp. 1075-85. VOLATILE BASES OF TOBACCO SMOKE. In: Proceedings of the Fourth International Tobacco Scientific A 11210 Congress. The National Tobacco Wakeham, H. and Silberman, H. Board of Greece, Athens, Greece, EFFECT OF CELLULOSE ON TASTE OF Sep 19-26, 1966, pp. 1011-8. =MET SMOKE. In: Proceedings of the Fourth International Tobacco Scientific Congress. The National A 11205 Tobacco Board of Greece, Athens, Stedman, R. L. and Miller, R. L. Greece, Sep 19-26, 1966, pp. THE ALKYLATING ACTIVITY OF 1086-92. CIGARETTE SMOKE. In: Proceedings of the Fourth International Tobacco Scientific Congress.The National A 11211 TobaCco Board of Greece, Athens, Williamson, J. T. and Allman, D. R. Greve, Sep 19-26, 1966, pp. THE DISTRIBUTION OP TOBACCO SMOKE CONSTIT- 1019-24. UENTS BETWEEN THE VAPOUR AND PARTICULATE

43 A 11211 (continued) PHASES. Ins Proceedings of the Fourth A 11229 International Tobacco Scientific Congress. Frasca, J. M., Auerbach, 0., Parke, V. R. The National Tobacco Board of Greece, and Jamieson, J. D. Athens, Greece, Sep 19-26, 1966, pp. 1093- ELECTRON MICROSCOPIC OBSERVATIONS OF 101. THE BRONCHIAL EPITHELIUM OP DOGS. I. Control Dogs. Experimental and Molecular Pathology_ 9(3):303:7g, A 11212 bec 1968. Waltz, P., Hausermann, M., and Hirsbrunner, R. FACTORS INFLUENCING THE RETENTION OF A 11232 SMOKE CONSTITUENTS IN CIGARETTE. Ins Pillsbury, H. C., Bright, C. C., O'Connor, Proceedings of the Fourth International K. J., and Irish, F. W. Tobacco Scientific Congress. The National TAR AND NICOTINE IN CIGARETTE SMOKE. Tobacco Board of Greece, Athens, Greece, Journal of the Association of Official Sep 19-26, 1966, pp. 1102-14. Analyticir Mimiste 62(3):4g'6 -62, May I96 g.

A 11220 Mathe, 0., Amiel, J.-L., and Dore, J.-P. A 11236 LES NEOANTIGENES DES CELLULES CANCEREUSES Craddock, V. M. ET LEURS SIGNIFICATIONS. (NEOANTIGENS OP STABILITY OP DEOXYRIBONUCLEIC ACID CANCEROUS CELLS AND THEIR SIGNIFICANCE.) METHYLATED IN THE INTACT ANIMAL Revue Francaise d'Etudes Cliniques et BY ADMINISTRATION OF DIMETHYL- EICIOgiques 13(0)7131=10, Dec 1T687- NITROSAMINE. Biochemical Journal French (Abs.) 111(4)1497-502, Feb 1969. The neoantigens induced by chemical carcinogens or oncogenic viruses or by A 11240 mechanisms of derepression of the synthe- Leaver, D. D., Swann, P. F., and sis of embryonic molecules have several. Magee, P. N. and, sometimes, obscure biological sig- THE INDUCTION OF TUMOURS IN THE RAT BY A SINGLE ORAL DOSE OF nificances. They are not specific of cancerization and can be found in the N-NITROSOMETHYLUREA.British absence of cancer; they may play a role Journal of Cancer 23(1)317747, in the partuseoplastic syndromes and per- Rai-1969. haps in autoimmune diseases. They may permit the detection of the passage of a viral genome, even though it is concealed A 11245 under another protein coat. (Author Brimblecombe, R. W. and Rowsell, D. O. Abstract) A COMPARISON OF THE PHARMACOLOGICAL ACTIVITIES OF TERTIARY BASES AND THEIR QUATERNARY AMMONIUM DERIJATIVES. International A 11224 Jourlal of NeuropharmacologY Morgan, W. K. C. 8(2)11S141, Mar 1969. RISK OF LUNG Ca IN FILTER CIGARETS. Current Medical Digest 36(3)1228, Mar 1969. A 11248 Le Page, R. N. and Christie, O. S. A 1122? INDUCTION OF LIVER TUMOURS IN THE Miller, F., Freeman, W. J., and Stedman, RABBIT BY FEEDING DIMETHYLNITRQSAMINE. R. L. British Journal of Cancer 23(1)1125-31, THE EFFECT OF ADDITIVES ON THE COMBUSTION REF-1139. TEMPERATURE OF CIGARETTES.Beitrage tun Tabakforschung 4(7)1269-74, Dec 1968. A 11249 Matsuyama, M., Suzuki, H., and Nakamura, A 11228 T. Thornton, R. E. and Valentine, C. CARCINOOENESIS IN dd /I MICE INJECTED DETERMINATION OF THE BALANCE OF DURING SUCKLING PERIOD WITH URETHANE, CARBON-14 ACTIVITY ADDED TO CIGARETTES. NITROGEN MUSTARD N-OXIDE, AND NITROSO- Beitrale Jur Tabakforschung 4(7):287- URETHANE.British Journal of Cancer 92, Dec 1111. 23(1)1167 -717n77-1169.

44 A 11255 A 11262 (continued) Brown, G. B. during gravidity. Observations covering PURINE N-OXIDES AND CANCER. Ins David- 3,0:10 patients could not incontrovertibly son, J. N. and Cohn, W. E. (Editors). demonstrate the teratogenic effect of Progress in Nucleic Acid Research, 8 Vole., nicotine. However, the decreased weight Academic Press, Inc., New York City, N.Y., and the higher mortality rate of the 1968, pp. 209-55. newborn are significant.

A 11256 A 11264 Verhulst, H. L. and Crotty, J. J. Harke, H.-P. and Drews, C.-J. TOXICITY OF COMMON HOUSEHOLD ITEM. U.S. EINE EINFACHE METHODS ZUR OEWINNUNO Department of Health, Education, and OASFORMIOER TABAKRAUCHBESTANDTELLE. Ihre Welfare, Public Health Service, Consumer Anwendung Zur Bestimmung des Kohlenmon- Protection and Environmental Health oxides im Rauch. (A SIMPLE METHOD FOR Service, Food and Drug Administration, PREPARING OASEOUS CONSTITUENTS OF TOBACCO Washington, D.C., National Clearinghouse SMOKE. Its Utilization for the Determin- for Poison Control Centers Bulletin, Mar - atio ofCarbon Monoxide in Smoke.) Apr 1969, 6 pp. Beitnrage zur Tabakforschunm 4(7)3275-7, Dec 1969,-Nrman (Abs.)

A 11257 The present paper describes a simple Bond, B. and Orr, J. W. device designed for the analytical smoking THE EFFECTS OF A SINGLE DOSE OP 7,12 - of single cigarettes and capable of DIMETHYLBENZ(a)ANTHRACENE OF THE EPIDERMIS collecting the gaseous constituents of AND HAIR FOLLICLES OF MICE, WITH NOTES ON tobacco smoke. The trap has been used CONCURRENT CHANGES IN THE OVARIES AND to determine the carbon monoxide content ADRENALS. British Journal of Cancer 23 of the smoke of cigarettes made i'rom reconstituted tobacco by gas chromatography. (Author Abstract).

A 11262 Czeizel, E. A 11265 A LEOELTERJEDTEBB ELVETETI CIKKEK HATASA Lorenz, H. W. and Seehofer, F. A MAGZATI FEJLODESRE. (EFFECTS OF THE UNTERSUCHUNOEN MIT EINEM VERBESSERTEN COMMONEST HABIT FORMINO SOCIAL ADDICTIONS DENSIMETER ZUM PRUFEN DER FUL1FARIOKEIT ON THE DEVELOPMENT OF FETUS.) VON SCHNITTABAK UND DER HARTE VON OyermekgarogYaszat 19(3)3399-402, Aug CIOARETTEN. (INVESTIGATIONS WITH AN 1968, Hungarian (Abs.) IMPROVED DENSIMETER FOR TESTING THE FILLING CAPACITY OF cur TOBACCO AND THE The teratogeny of habit forming social HARDNESS OF CIGARETTES.)Beitragg zur addictions affecting the Xyemato-pathogen- Tabakforschun 4(7)3293-30;571SiYI911; esis is a clinical problem of worldwide GRR (Abs.) attention. The deleterious genetic effect of caffeine causing mutation in bacteria Maintaining the approved principle of was demonstrated by Novick and Szilard. determining the filling capacity of tobacco The mental retardation of issues of chronic and the hardness of cigarettes by measur- alcoholics is well documented. Experiments ing the change in volume under constant with rats (30 portent ,lcohol solution) pressure within a constant time, the resulted in embryonic deteriorations. instruments IDensimeter° and 1Kompresel. However, 1-10 percent alcohol solution meter" have been combined, automatized confined to 1 day consumption appeared and supplied with improved indicator to be innocuous. During breast feeding devices. Moreover, for measuring the thecontinuousconsumption of 10 percent hardness of cigarettes, the shape of the alcohol solution appeared to be deleter- loading platforms has been changed. The ious on the newborn rate. These observa- influence of different parameters on the tions coincide with the work of Nylander fillingpowerof tobacco and the hardness on clinical subjects. Simpon called of oigarettes for several types of blends attention to premature births precipitated has been investigated with this combined by smoking versus abstinent subjects. set of apparatuses. The results hitherto The body weight retardation of the newborn obtained confirm the usefulness of the (up to 250 g) appear to be proportional new instrument for measuring the hardness with the number of cigarettes smoked. of cigarettes and of filter rods as well The frequency of miscarriage and stillbirth as for determining the filling capacity appear to be related to smokin4. Fraumeni of cut tobacco for quality control, routine and Ravenholt et al. have observed a checks and basic investigations. (Author decline in male births due to smoking Abstract). A 21266 A 11260 (continued) Zorbalae, D. I. times relative to I- methylphenanthrene, BESTIMMLNO DER BINDUNOSWARME DES WASSERS taken au an internal ataniard, of 6 IM TABAK. (DETERMINATION OF THE HEAT OF polynuclear aromatic hydrocarbons, single BINDING OF WATER IN TOBACCO.) Beitr e and mixed) in addition he determines the z Tabakforechung 4(7):301-7, ec area and the relative areas with respect Girt= (Abs.) to the internal standard. (Author Abstract). The evolution of the desorption curves of a Oreek cigarette brand at temperatures of 15 to 30 degrees C is presented by A 11281 means of the formula established by Peretti, S., Maltoni, C., and Ohetti, O. Brunauer, Emmet and Teller, and used to SINEDOISMO D'AZIONE ONCOOENA DEL 4- determine the heat of binding of water DIMETILAMINOAZOBENZOLO E DEL TETRACLORURO at 40 percent to 70 percent relative DI CARBONIO SUL FEOATO DI RATIO. humidity of air.The mechanical linkage (SYNERGISM OF ONCOOENIC ACTION OF force of water is shown to be confirmed 4-DIMETHYLAM1NOAZOBENZENE AND CARBON by the calculated heat values. TETRACHLORIDE IN RAT LIVER. Cancro (Author Abstract). 21(1)03-80, 1968, ItalianAbli75---

The presert report deals with the A 11270 study of oncogenic effects on the Frejaville, J.-P. liver of ma/e and female albino rat SITES D'ACTION CELLULAIRE DES TOXIQUES. of long treatment with DAB (in diet) (SITES OF ACTION OF POISONS.) Annales (Group 1), CC1-4 (by inhalation) de 1'ADSAVA11912Lle Erancaise (Group II), and DAB + CC1-4 (Group III). M5-17TRE,V=Diili-1-9-68,-French (Abs.) No liver tumors have been observed after 35 weeks treatment with CC1-4. Liver In a general review of the sites of tumors have been detected in male and action of poisons in the region of the female rate treated with DAB, and with cell, it would seem pertinent to out- DAB + CC1-4. In the animals treated line the different antra- cytoplasmic concurrently with DAB and CC1-4 the formations. The nucleus and its main incidence of tumors was markedly higher chemical constituent, DNA, are submitted and the latent eriod shorter than in to the action of carcinogenic agents, the animals receiving DAB alone.The such as dinethylnitrosamine and anti- last result clearly confirms that CC1-4 neoplastics. The mitochondria are is oncogenic for rat liver (although in sensitive to different inhibitors of the present experimental conditions it the cytochrome or quinone chain did not produce hepatic tumors when and to the rupture of oxi,:ative given alone), and indicates a synergism phosPhorylation (dintrophenol, between the oncogenic effects of DAB thYroxine). The microsomes are the and CC1-4.Comparative study of liver quaai elective site of the breakdown changes at the different stages of the of a number of drugs, thanks to the treatments in the three groups indicates drug enzymes. Finally, certain a clear parallelism between neoplastic poisons produce enzymatic inhibi- response, expressed both by incidence and tions which resemble hereditary meta- latent period of tumors, and type bolic anomalies. (Author Abstract) and degree of cirrhosis, amount of newly formed c.;,,cts, and degree of liver cell hyperilasia. A 11280 Savino, A. DETERmImAzIoNs na VIA OAS CROMATOORAFICA A 11284 DEOLI IDROCARBURI AROMATICI POLICICLICI. Maltoni, C., Peretti, S., and Ohetti, O. (DETERMINATION OF AROMATIC POLYCYCLIC SINEROISMO D'AZIONE °ROWENA DELLA HYDROCARBONS BY OAS CHROMATOORAPHY.) 2-N-FLUORENILACETAMIDE E DEL TETRA- ivista Italians d'Igiene 28(1-2)166-65, CLORURO DI CARBONI° SUL FEOATO DI an- pr 1968, Italian (Abs.) RATIO. (SYNERGISM OF ONCOOENIC ACTION OF N-FLUOREN-2-YLACETAMIDE The author reports the current AND CARBON TETRACHLORIDE IN RAT literature concerning the determination LtalianIVER.) Centro 21(1)t63-72, 1968, of the polynuclear aromatic hydrocarbons I (ni7T- by gas chromatography. Using columns packed with 5 perCent SE-30 coated on 60- The present report deals with the 80 mesh Chromosorb W, flame ionization study of oncogenic effects on the liver detection and programmed temperature, of male and female albino rate of long the author fixes the times the retention term treatment with 2-FAA (in diet temperatures and the relative retention (Group) I), CC1 -4 (by inhalation)iOroup

62 46 A 11287 (continued) A 11284 (continued) besides NO2. In the fresh smoke from II), and 2-FAA+CC1-4 (Group III). No Straight Virginia cigarettes, i.e. 2-5 liver tumors have been observed after sec. after generation, no NO2 was 35 weeks treatment with CC1-4.Hepatomas detectable. Under the same conditions, have been detected in male and female blended cigarettes showed a content of rats treated with 2-FAA, and with about 5 mcg. NO2 /cigarette. 60 secondo 2-FAA+CC1-4. In the animals treated after smoke generation, about 200 veg. concurrently with 2-FAA and CC1-4 the NO2/cigarette have been determined. incidence of tumors was Markedly higher These results show that of the nitrogen and the latent period shorter than in oxides only NO is present in fresh the animals receiving 2-FAA alone. cigarette smoke.The autoxidation to Comparative study of liver changes at NO2 occurs to a considerable extent the different stages of the treatments within 60 seconds. in the three groups indicates a clear parallelism between neoplastic response, expressed both by incidence A 11289 and latent period of tumors, type and DiPaolo, J. A., Donovan, P., and Nelson, R. degree of cirrhosis, amount of newly QUANTITATIVE STUDIES OF rsVITRO formed ducts, and degree of liver cell TRANSFORMATION BY CHEMlar CMTUTNOGENS. hyperplaeia. Journal of the National Cancer VaTEUte-471151:867-74, pulT69.

A 11285 Elmenhorst, H. and Harke, H.-P. A 11290 UBER DIE BILANZ DES STICKSTOFFES IM Stjernsward, J. CIOARETTENRAUCH. (NITROGEN BALANCE IMMUNOSUPPRESSION BY CARCINOGENS. IN CIOARETTE SMOKE.) Beitrs e zur In: De Weck, A. (Editor), Antibiotica Tabakforsch 4(7)12 , oec et Chemotherapia, Vol 15. Basel, German(Abe.)) Switzerland, S. Karger, 1969, pp. 213-33. Total nitrogen and nicotine contained in cigarette awoke condensate and condensate fractions have A 11291 quantitatively been estimated. The Conzelman, O. M., Jr., Moulton, J. E., results show that only 5 to 36 percent Flanders, L. E., III, Springer, K., and of total nitrogen can be related to Crout, D. W. nicotine. It is tried to determine INDUCTION OF TRANSITIONAL CELL CARCINOMAS the balance of nitrogen in smoke con- OF THE URINARY BLADDER IN MONKEYS FED densate.The calculations made suggest 2-NAPHTHY1AMINE. Journal of the that, for example, within the group National Cancer 'nititUri M571.825-36, of nitrogenous compounds, there might May 1969. be smoke constituents which are eti11 unknown and which occur at relatively high concentrations. (Author Abstract) A 11297 Rosenkrantz, H. and Sprague, R. BIOCHEMICAL SCREEN TO INVESTIGATE A 11287 WHOLE SMOKE AN.) VAPOR PHASE EFFECTS IN Barkemeyer, H. and Seehofsr, F. MICE. Archives of Environmental 2UR UNTERSUCHUNO DER OAS-DAMPF-PHASE Health 18(6):917724 DES CIOARETTENRAUCHES. 2. Mitteilungi Zur Bestimmug des Stickstoffmonoxids (NO) aus der OasPhase des CigaretteAn- A 11298 rauches. (INVESTIOATION OF THE OS- Aviado, D. M. and Carrillo, L. R. VAPOR PHASE OF CIGARETTE SMOKE. aid HORMONES AND PULMONARY EFFECTS OF Reports Determination of Nitric TOBACCO. Archives of Environmental Oxide (NO) of the Gas Phase of Health 18(g)3925-33, Jun 1969. Cigarette Smoke. Beitrage img Tabakforschung 4 7)1278-82, Dec 1968, Osman (Abs.) A 11304 Nikki, P. The concentration of NO in the INFIVENCE OF SOME CHOLFSOMIMETIC AND mainstream smoke of commercial cigarettes CHOLINOLYT1C DRUGS ON HALOTHANE with different tobacco types and blends SHIVERING IN MICE.Annales Medicinal has been shown tr.. be in the range Experimentalis et BiBTERTET between 250-1W, ppm, i.e. 110-660 16(4)1521-30, 1768. meg.NO/cigartAe. Contrary to other methods, the new procedure enables the differentiated determination of NO 4 A 11339 A 11360 (continued) Knox, W. E., Horowitz, M. L., and Friedell, G. H. The morphology of various types of cul- THE PROPORTIONALITY OF GLUTAMTNASE tured cells, capable of inducing neoplasms CONTENT TO GROWTH RATE AND MORPHOLOGY when injected in newborn mice, was OF RAT NEOPLASMS.Cancer Resea:ch investigated. The aim of this study was 29(3):669-80, Mar 10117 to see whether peculiar morphological characteristics could be evidenced in malignant cells.We could show that A 11349 cultured, tumor-inducing cells, as well Brown, D. A. as derived tumor cells, contain virus- RESPONSES OF NORMAL AND DENEIWATED CAT like particles in their cytoplasm. These SUPERIOR CERVICAL GANGLIA TO SOME are not present in control cells.The STIMULANT COMPOUNDS. Journal of aspect of these particles varies according Physiology 201W:225-n7W n69. to the type of cell. In fact in tumor cells they are surrounded by a membrane, which however is not present in the A 11353 cultured cells inducing the tumor.The Lesca, P., Toutain, D., and Truhaut, R. data presented are briefly discusaed. AUGMENTATION TRES PRECOCE DE L'ACTIVITE (Author Abstract). DE LA DESOXYRIBONUCLEASE ACIDS FULMONAIRE DE LA SOURIS SWISS APRES TRAITEMENT PAR LE BENZO-3-4-PYRENE. (VERY PRECOCIOUS A 11361 Laval Medical. CTLEHAE szniCrAFTER ETUDE CANADIENNE SUR LA TENEUR EN GOUDRON :ATM:WITH374T-rBEIN )°NCoMptek ET EN NICOTINE DES CIGARETTES. (CANADIAN Rendus Hebdomadaires des Seances de STUDY ON THE PERCENTAGE OF TAR AND 117ca emie des Sciencir2;60, Senis D): NICOTINE IN CIGARETTES.) Laval Medical f23870, Feb 'f4, 1969, French (Abs.) 40(1):143-4, Jan 1969, FreiarASI7T---

One Mg 3,4-benzopyrene was injected Mr. John Munro, Camden Minister of a.c. into 150 Swiss mice 1 day following Health and Social Welfare, hea commented birth; untreated Swiss mice served as on the study of the ter and nicotine con- controls. Lung homogenates of tent of 85 kinds of cigarettes sold in periodically-sacrificed animals were then Canada. He offers advice on the interpre- tested for DNaSe activity. Tritiated DNA tation of the results with the reminder from E coil was used in the teats with that a low tar and nicotine content would measaiiiiiir of radioactivity made by a have no effect on the percentage of carbon Packard scintillation counter. In un- monoxide of the gas phase of the smoke. treated mice, the DNase activity increased For those who cannot stop smoking entirely slightly with age between the 3rd and 20th he suggests these measures: wait a longer day then stabilized between the 20th and time between cigarettes; increase the in- 70th day. A complete absence of patholog- terval between puffs; do not inhale; do not ical manifestation in the lunge was ob- keep the cigarette in the mouth between served. A higher DNase was observed in puffs*, and discard longer Cutts. treated mice. Between the 3rd and 9th day, one observed an average DNase activity of 27 percent as compared with controls; A 11366 the activity rose to 81 percent between the Thust, R. and Janisch, W. 10th and 35th day.No pathological changes CYTOPHOtOMETRISCHE UNTERSUCHVNGEN USER were observed under the microscope. From DEN DNS-UND HISTONGEHALT EX PERIMENTELL the 42nd to 67th day, the activity role to INDUZIERTER 1VMCREN DES ZENTRAINERVEN- 157 percent with all samrles, but one, SYSTEMS DER RATTE. (CYTOPHOTOMETRIC STUD- bearing at least 1 nodule. IES ON THE DNA AND HISTONE CONTENT OF EXPERIMENTALLY-INDUCED TUMORS OF THE CENTRAL NERVOUS SYSTEM OF THE RAT./ A 11360 Virchows Archly 8 2ellpathologie 2(2)1 Violante, A., Poletti, A., and Marchegiani, TTCZ37VebT176,airman Ins.) M. SULLE CARATTERISTICHE MORFOLCOICHE DI Eight tumors of the central nervous CELLUE DI TOPO DI COLTURA PRIMARIA E system of the rat induced by NMU (methyl- DI LINEA: NORMALI 0 PORTATRICI DI nitrosourea) or 6,9,10-trimethy1-1,2- VIRUS E CAPACI DI DARE TUMORE. (MOR- benzanthracene and one NMU-induced PHOLOGICAL CHARACTERISTICS OF PRIMARY eatracanial tumor were stained by the CULTURED MOUSE CELLS OF NORMAL, VIRUS Feulgen method and fastgreen dye for INFECTED, AND TUMOR-INDUCING STRAINS.) cytophotometrlc determination of the DNA Annals dell' Istituto Superior* di and hletone content of the nuclei. From gam 3m0.254.60, 1968, Italirn (Abs.) one NMU-induced intracranial sarcoma

44 A 11366 (continued) A 1137? (contin :el) two successive transplant generations were (3) For a rapid evaluation of environ- measured. The DNA and histona determina- mental pollution from tobacco smoke the tions of the sarcomas indicated (1 extra- carbon monoxide may be taken as a signifi- cranial, 4 intracranial, 1 intramedullary) cant index, because: (a) it ie always the tendency for development of a hyper- present in very high quantities in room- diploid DNA-stemline up to tetraploid ed:, where people smoke; (b) in these levels. In our material only the second ambients, if they are heated rationally, transplant generation of an intracranial it is produced exclusively by tobacco sarcoma and an extracranial sarcoma reached amoke; (c) it may be evaluated easily, this ploidy.As we suppose, the process of rapidly and exactly by "Draegerie Syetem". ploidy change in sarcomas of the central nervous system normally is interrupted by the premature death of the animal. The two A 11373 measured oligodendrogliomas induced by Plise, O. B. different carcinogens (NMU and 6,9,10- o KAltiEPOrDHIXTA A4+NEOW CCEAMSW trimethy1-1,2-benzanthracene) show no de- PE3CPSTMITO4WV8MA. viations from the normal values. In a glioblastoma multiforue the giant nuclei 0 KANTSEROGENNOSTI KHIMICHESEIHN show high grades of ploidy. The histone SOYEDINENIY REZORSTIVNOGO DEYSIVIYA. content has no constant relation to the (CARCINCOENICITY OF CHEMICAL COMPOUNDS OF DNA values, which could be explained by RESORPTP/E ACTION.)Voprosy Onkolo 11 degenerative processes. (Author Abstract) 15(2)171-5, 1969, Russian tAbs. In experiments on 59 mice of line A 11371 CC57W, 55 rats and 3 dogs the carcino- Polonovski, J. and Etienne, J. genic action of 2--naphthylamine was METABOLISME HEPATIQUE DES MEDICAMENTS. demonstrated.Tumors developed in 28 (HEPATIC METABOLISM OF DRUOS.)Thera ie percent of the mice (sarcomas at the 24(1):7-25, Jan-Feb 2969, French e. site of injection, tumors of the lungs, skin, leukosis, etc.), in 40 percent The various drugs are mostly transform- of rate (sarcomas at the site of injec- ed at the level of hepatic microeomes. The tion, tumors of the kidney, liver, etc.). metabolites are usually more polar than In doge tumors of the bladder were precursory drugs.The structure of hy- observed. It le concluded that local droxylation enzymatic systems and the effect of this ager.t ie not related with induction of hydroxylases by drugs are more peculiarities of this species of animals, closely studied.Benzopyrene and methyl- while resorptive action is stipulated by cholanthrene induce the formation of hy- speclee of animals (metabolic peculiarities). droxylases of aromatic nuclei active on (Author Abstract) benzopyrene, phenobarbital and zoxazolamine. Conjugation reactions ere mentioned briefly. A 11376 Scasselleti Sforzolini, O. and Savino, A. DETERMINAZIONE DELLA NICCTXNA NEL FUMO A 11372 DI SIOAREITA CONmerom SPETTROFOTOMETRICO Scassellati Sforzolini, O. and Savino, A. MODIFICATO. (DETERMINATION OF NICOTINE VALUTAZIONE DI UN INDICE RAPIDO DI 410N- IN CIOAREITE SMOKE BY A MODIFIED TAMINAZIONE AMBIENTALE DA FUMO DI SPECTROPHOTOMETRIC METHOD.)Rivista SIOARETTA, IN RELAZICNE ALLA COKPOSIZIONE Italiana d'LLUgg28(1-2):31-rE7---- DELLA PASE OASSOSA DEL FUMO. (EVAIXATICN 077W11761;-Trilian (Abs.) OF A RAPID INDEXOF ENVIRONMENTALPOLLU- TION BY ctwarrrs SMOKE IN RELATION TO THE The authors review the main techniques COMPOSITION OF THE OAS PRASEOF THE soon.) for the dosage of nicotine in cigarette Rivista Italians d'I lone 26(1-2):43-55, smoke and explain their respective advan- 707417Trysrre. In (. e.) tages and limitations.They report the results of the setting-up of a spectro- From their researches the authors draw photometric method modified by the the following conclusions: (1) The "technique of overload'. This method presence of toxic gases in high concentra- presents, in comparison with nicotine tion both in main-stream and in sidestream determination by the gravimetrIc and cigarette eloko is confirmed. (2 The spectrophotometric technique of Willits main-stream smoke of five cigarettes and col l., considerable advantages both for contains about the maglmum allowable the precision of analysis and the rapidity concentration (N.A.C.) of 00/cubic m Of execution. (Author Abstract) (110 mg) and it has been also shown that in the air of a Small cockpit (as in a car) the M.A.C. may be easily reached after smoking about a packet of cigarettes.

A$ 49 A 11403 A 11452 (continued) Seltmann, H., Ross, H., and Shaw, L. METHYLBERZ( a) ANTE:RAC EVE -12-14C IN VITRO. TIME OF TOPPING AND FETEODS OF SUCKERING Biochemical-Pharmacology 18(3) :riT0 ON YIELD VALUE AND ALKALOID CONTENT OF WI' 1969. BURLEY TOBACCO.Tobacco 168(2):22-5, 1969. A 11460 A 11406 Jasmin, O. and Riopelle, J. L. Lee, B. K. and Murphy, O. TRANSPLANTATION DE TROIS TUMEURS DETERMINATION OF ARSENIC CONTENT OF RENALES INDUITES CHEZ LE RAT PAR LA AMERICAN CIGARETTES BY NEUTRON ACTIVATION DIMETHYLNITROSAMINS. (TRANSPLANTATION ANALYSIS. Cancer 23(6):1315-7, Jum 1969. OF THREE RENAL TUMORS INDUCED IN RATS BY DIMETHYLNITROSAMINE.) International Journal of Cancer 4(3):229-31I, May 15, A 11416 MUT-Trench (Abs.) Liang, C. C. and Quaatel, J. H. EFFECTS OP DRUGS ON THE UPTAKE OF Three renal tumors induced in rats by ACETYLCHOLINE IN RAT BRAIN CORTEX dimethylnitrosamine were serially SLICES. Biochemical Pharmacology transplanted in animals of the same strain 18(5):118t-94, May 1969. and one of these tumors was futher studie. in tissue culture. Originally, these tumors exhibited the histologic character- A 11420 istics of two different types of stromal Siegel, W. V. and Shklar, G. nephromas. Their growth rate tonded to THE EFFECT OF DIMETHYL SULFOXIDE AND increase with the number of passages and TOPICAL TRIAMCINOLONE ON CHEMICAL the percentage of takes was higher in CARCINOOENESIS OF HAMSTER BUCCAL POUCH. males than in females. In the course of Oral Surgery, grill Medicine and Oral successive passages, the three tumors FrEgology 27(67T772:77-.7711.M. retained their sarcomatous aspect and either remained undifferentiated or underwent progressive differentiation A 11422 into primitive nesenchyme, into smooth Hagopian, M. or striated muscle tissue. The epithelial BLUE TETRAZOLIUM REDUCTION BY WHOLE component of one of these tumors persisted TOBACOp SMOKE AND GAS PHASE COMPONENTS. until the third passage: it was well deli- Environmental Science & Technology mited from the surrounding sacomated 3(6)1561-9, JuiiT1r77 tissue 60 that the possibility of a metaplastic transformation seems unlikely. It appears that the transplantation of A 11423 these neoplasms resulted in a simplific- Moon, R. C. ation of their structural organization RELATIONSHIP BETWEEN PREVIOUS REPRODUCTIVE and that they evolved towards a mesenchymal HISTORY AND CHEMICALLY INDUCED MAMMARY differentiation of the muscular type. CANCER IN RATS. International Journal (Author Abstract) of Cancer 4(3):3127-

A 11461 A 11424 Dini, W. Yeager, H. Jr. DETERMINACAO DAS TRANSAMINASES ALVEOLAR CELLS: DEPRESSANT EFFECT OF OLUTAMICO-PIRUVICA E OLUTAMICO- CIGARETTE SMOKE ON PROTEIN SYNTHESIS. OXALACETICA EM NAO FUMANTES E Proceedings of the Society for Experimental FUMANTES DE CIOARROS. (DETERMINATION trOn---M MdIZThe 131arra7-50, May OF THE OLUTAMIC-PYRUVIC AND GLUTAMIC- OXAIACETIC TRAMSAMINASES OF NONSMOKERS AND CIGARETTE SMOKERS.) Hospital 75(3): 153-60, Mar 1969, Portuguese kAbs.) A 11440 Camber, P. J., Shore, S. R., and Using the REITMAN-FRANKEL method, Avlado, D. M. the author did not find statistically BRONCHOPULMONARY AND OASIROINTESTINAL any important difference between the EFFECM OP raums. Archives blood-rates of glutamic-pyruvic and Internationales de Pharmacodynemie et glutamic-oxalacetic transamlnases 373TET7511777(17s1-27, Jan 1969. (alanine and aspartic aminotransferasee) between nonsmokers and smokers of cigarettes. The P test for the analysis of A 11452 the obtained results was employel. Jellin:k, P. H. and Smith, O. (Author Abstract) METABOLISM OP 7-HYDROXYMETHYL-12

go A 11465 A 11472 (continued) Concours Medical. (FORMATION OF CARCINOGENIC HYDROCARBONS FUMEZ SOUFRE (7) (SMOKE SULFURED (?).) DURINO THE THERMAL TREATMENT OF FOODS. Concours Medical 91(9):1740, Mar 1, PART I. METHOD FORTHE DETERMINATION 1969, French ',Abs.) OF 3,4-BENZOPYRENE IN FOODS IN THE PRESENCE OF OTHER POLYCYCLIC AROMATIC Tobacco smoke blocks the phago- COMPOUNDS.) Nahrun12(6):639-48, cytic action of alveolar macrophages. 1968, Oerman TAbs. Very weak concentrations of sulfured antioxidants (0.2 to 0.4 micromolea A method is described which permits of glutathione or cysteine per ml of the reproducible determination of smoke) can prevent this harmful 3,4-benzopyrene in foods in the presence action.This has been demonstrated of other polynuelear aromatic compounds in vitro in rabbit macrophages by by means of extractive, chromatograp%ic been of Boston. and ultra-violet and spectrofluorometric procedures. By fluorescence spectral analysis 3,4-benzopyrene concentrations A 11468 little as 0.1 microg./kg may be Tka',.-ni, 0. A. detected. For concentrations greater 0 ,47.14911 104EHOOXEJE3U11P1IncOOCTPonnyLIEBOA than 1 microg.Ag, the losses due to sorElsiOTWKOPDOPYrneNtKrOmmtvw-210. concentration and separation are likely to be of the order of 10 to 13 percent TSITOKHIMIYA NADPOCHECHNOY ZHE1 as estimated from the resulta of model PRI PODOSTROY LUCHEVOY BOLEZNI G. experiments. For concentrations less INKORPORIVANNOGO POLONIYA-210. than 1 microg./Kg the losses were (CYTOCHEMISTRY OF ADRENAL OLANDS estimated at nearly 35 percent. (Author DURING SUBACUTE RADIATION ILLNESS DUE Abstract) TO INCORPORATION OF POLONIUM-210). Radiobiolo iia 9(1)187-93, Jan-Feb , use an (Abs.) A 11474 Bair, W. J., Porter, N. S., Brown, D. P., Pure-bred male rats, weighing and Wehner, A. P. 220-300 g4 were treated with Po-210 APPARATUS FOR DIRECT INHALATION OF (0.02 mC/kg) and then sacrificed CIGARETTE SMOKE BY DOGS. journal after 5, 12, 30, 50, 60 and 100 days. of Applied Physiology 26(6):847-50, The dynamic intensity of the hieto- Win1969. chemical reactions on ketosteroids, lipids, and succino-dehydrogenasea as well as changes in the micro structure A 11475 of the adrenals of rats under conditions Shear, M. J. of subacute irradiation illness from YAMAOIWA'S TAR CANCER AND ITS the incorporation of P0-210, was HISTORICAL SIGNIFICANCE.Gann evidence of the phasing and synchroniza- 60(2)1121-7, Apr 1969. tion of the functional activity in the cortex and medullary substances. In the earlier period after introduction A 11476 of Po-210, there was a mobilization of Kande, M., Ishida, A., Yoshida, H., hormonal substances together with Maki,Y., and Tanaka, S. inhibition of their synthesis. In the EFFECT OF ANTINEOPLASTIC AOENTS following stage, there was a development ON MICROSOMAL ENZYMES.Kumamoto of compensating processes and again a Medical Journal 21(4):143877517 30, lessening of the intensity of hormone synthesis. In the final period, the 113117 normalization of the function of the medullary substances was combined with A 11477 the functional intensity of the adrenal Kanda, M. and Tanaka, S. cortex owing to the deficit of corticoid THE EFFECT OF VITAMIN B OROUP- AND hormones in the organisms. L-ASCORBIC ACID-DEFICIENCIES ON THE MICROSOMAL ENZYMES.Kumamoto Medical Journal 21(4)1149-55,UFF5 D: A 11472 Fritz, W. ZUR BILDUNG CANCEROCIENER KOHLENWASSER- A 11478 STOFFE BEI DER THERMISCHEN BEHANDLUNG VON Maki, Y. IEBENSMITTELN. 1. MITT. METHODE ZUR MEPHENOXALONE HYDROXYLATION IN RAT BESTIKMUNG VON 3,4-BENZPYREN NEREN LIVER MICROSOMES. Kumamoto Medical ANDEREN POLYAROMATEN IN LEBENSMITTELN. Journal 21 (4 ) 69-711777-c-7007117117, A 11479 A 11496 (continued) Kande, M., Yoshida, H., Ishida, A. Maki, DEOXYRIBONUCLEIC ACID IN AQUEOUS SOLUTION. Y., and Tanaka, S. Biochemistry 8(6):2291-8, Jun 1969. EFFECT OF ANTINEOPLASTIC AGENTS ON THE INDUCTION OF CYTOCHROME P-450 AND MICROSOMAL Fe-x.Kumamoto Medical A 11497 Journal 21(4)1190-1, Dec Shklar, G., Turbiner, S., and Siegel, W. CHEMICAL CARCINOGENESIS OF HAMSTER MUCOSA.Archives of Pathology 87(6): 11483 637-42, Jun 195'. Odashima, S. EXPERIMENTAL CARCINOMA OF THE GLANDULAR STOMACH IN RATS.I. EFFECT OF 7,12- A 11500 DIMETHYLBENZ(a)ANTHRACENE OR 4- Davis, H. J. NITROQUINOLINg 1-OXIDE PLACED ON GAS-CHROMATOGFAPHIC DISPLAY OF ThT GLANDULAR STOMACH COMBINED WITH ORAL POLYCYCLIC AROMATIC HYDROCARBON ADMINISTRATION OF N,N,-(2,7- FRACTION OF JIGARera SMOKE. Talents FLUORENYDENE)BISACETAMIDE OR N- 16(5)1621-5, May 1969. NITROSODIETHYIAMINE. Gann 60(2):211- 22, Apr 1969. A 11501 Chemical Engineering. A 11485 SEARCH SPEEDS UP FOR "SAFE" BUT Stokinger, H. E. "SATISFYING" CIGARETTE. Chemical THE SPECTRE OF TODAY'S ENVIRONMENTAL Engineering 68(13)158-60, Jun 30, 1969. POLLUTION--USA BRAND: NEW PERSPECTIVES FROM AN OLD SCOUT. American Industrial H Serene Association A 11502 our7=a3Z)(3):195-21 , Play -Jun 1969. MacDonald, A. D. LETTUCE CIGARETTES.Practitioner 202(1210:731, May lar^"-- A 11486 Armitage, A. K., Hall, G. H., and Heneage, E. A 11503 A SMOKING SIMULATOR FOR THE CONTROLLED Food and Cosmetics Toxicology. PRESENTATION OF TOBACCO SMOKE TO THE SCOURGE OP THE TOBACCO INDUSTRY. LABORATORY ANIMALS. British Journal of Ford and Cosmetica Toxicology 6(6): Pharmacology 36(0121177277767orts. 797 9 ZS1717

A 11489 A 11527 Dale, E. and Scutchfield, F. D. Rybakova, M. O. PRCOESTERCNE METABOLISM BY 0 PeeePIDers*Ww6 ar4Ta1ilACAMI1MMFJE3MAN ADRENAL HOMOGENATES OF RATS TREATED KINK 11P14aMTCPWC-11AWCM O1lIEPOEW3E. WITH 7,12-DIMETHYLPENE(a)ANTKRACENE. British Journal of ExpeFimental 0 DIFFERENTSIROVIT EPITELIYA SLYUNNY101 ralF617gy 50(2):1-65-7I, Apr 2969. GHELEL BEIM KRY* PRI EKSDERIMENTALt NOM KANTSEROGENEZE. (ON DIFFEhENTIATION OF SALIVARY GLAND EPITHELIUM IN WHITE RATS IN A 11491 EXPERIMENTAL CARCINOOENESIS.)Voprosy Hozumi, M. Onkologli 15(4)t62-6, 1969, Russian (Abs.) INDUCTION OF SKIN TUMORS IN MICE BY PAINTING WITH 4-HYDROXYAMMOQVINOLINE In 40 white nonpedigree rats, DMA 1-OXIDE. Gann 60(2)1161-5, Apr 1969. was injected in :he submaxillary salivary gland. In 24 cases tumors of various histological structure developed: squamous A 11493 cell cancer, adenocarcinoma, cancer with Thomas, H. V. and Simmons, E. double differentiation of the epithelium, HISTAMIrE CONTENT IN SPUTUM FROM sarcoma, lymphosarcoma. In cancers ALLERGIC AND NONALLERGIC INDTVIDIMS. epithelial and connective tissue changes Journal of A lied PhysiolooY 26(6): were observed, that resembled muco- and 713777,77. cartilage-like portions of mixed human tumors. In the process of tumor growth salivary gland epithelium shows great A 11496 liability of differentiation that evidences Lesko, S. A., Jr., Te'o, P. O. P., and hietogenetic potentials of the epithelium. Umans, R. S. (Author Abstract) INTERACTION OF NUCLEIC ACIDS. V. CHEMICAL LINKAGE OF 3,4-BENEPYRENE TO A 11529 A 11531 (continued) Ramsey, J. M. amount inhaled with the cigarette smoke THE IMMEDIATE HAEMATOLOGICAL RESPONSE IN does not seem to be insignificant, Whether THE RAT TO EXPERIMENTAL EXPOSURES OF nickel actually reaches the reported CARBON MONOXIDE. Journal of Physiology cancerogenic effect appears at least to be 202(2):297-304, Jun 1R9. doubtful, consideringour own results and the publications available. (Author Abstract) A 11530 Hayashi, I., Yoshida, K., Marta, Y., Yamashita, A., Yoshikawa, K., and Ico, N, A 11533 JIKKENTEKI JIN SHUYO NO CHIRYO NI Chiculescu, O. KANSURU KENKYU. 1. MITOMYCIN C, ASUPRA EFECTELOR NICOTINE' PE PLAMINUL 5-FLUOROURACIL, 3-METHYLCHOUNTHRENE, IZOLAT DE BROASCA. (NICOTINE EFFECTS ALPHA-NAPHTHYL-ISOTHIOCYANATE OYOBI ON ISOLATED FROG LUNGS.) Stud11 al DIETHYLSTILBESTROL NO JIKKENTEKI JIN Cercetari de Fiziologie 13I8):501=g, SHIN() E NO EIKYO NI TSUITE (STUDIES ON 1968, Rumaiiian (Abs.-) THE TREATMENT OF EXPERIMENTAL KIDNEY TUMORS.1. EFFECT ON EXPERIMENTAL PharmacodynamPl motor effects of KIDNEY TUMORS OF MITOMYCIN C, 5- nicotine on the smooth muscle isolated FLUOROURACIL, 3-METHYLCHOLANTHRENE, from actual alkaloid concentration in ALPHA-NAPHTHYL-ISOTHIOCYANATE AND the bathing solution.A parallel can be DIETHYLSTILBESTROL.) Hinyokika KI.42 establiahed between the polyphasic motor 15(2):79-86, Feb 1969,-7gTEFFEF TAos.) effects on the same organ of successively increasing potassium or barium chloride The effects of various anticancer agents, concentrations and those elicted by such as mitomycin C (MMC), S-fluorouracil nicotine.These polyphasic motor reactions (5-FU), diethylstilbestrol (DES) and alpha- of lung muscles are to be ascribed to the naphthyl-isothiocyanate (ANI) on rat kidney dual, nervous and muscular, functional tumor induced by dimethylnitroaamine (DMN) structures of the lung and to the succes- were studied. In rats receiving DES and sive effects on these structures of the AN', the development of kidney tumors was above mentioned stimulators, which may ex- inhibited.Histologically, golden-brown ert their actions by similar mechanisms. pigments were observed in the cells of One can assume that the polyphase effects renal tubules in the groups of DES-treat- are related to a higher reactivity of ment. No significant effects of the other intraparietal nervous endinss, as compared anticancer agents were observed on the to that of the contractile substance itself. DMN-induced rat kidney tumors. (Author These different reactivities determine the Abstract) successive participation of both components to the evolution of the regstered pharmacodnamic effect. (Author Abstract) A 11531 Szadkowski, D., Schultze, H., Schaller, K.-H., and Lehnert, G. A 11535 GUR OKOLOGISCHEN BEDEUTUNG DES Di Bella, S., panazzolo, A., Scarpa, SCHWERMETAILGEHALTES VON LIGARETTEN. F., Cacciari, P., and Santoro, L. Filet -, Cadmium- und Nickelanalysen des SUL METABOLISMC OLICIDICO DELIE Tabeks Sowie der Gas- und Partikelphase. NEOPLASIE SPERIMENTALI E UMANE. (ONCOLOGICAL SIGNIFICANCE OF HEAVY 1 Parte. "Indagini Sperimentali METAL CONTENT OF CIGARETTES. Lead-, del Metabolisso Olicidico in Cadmium- and nickel analyses of Tobacco Neoplasie Indotte net Ratto as well AS of the Gas- and Particulate Mediante DMBA." (GLYCOSIDIC phase.) Archly fur Hy iene und METABOLISM OF EXPERIMENTAL AND Bakteriolgri-MSTr): - , err 969, HUMAN NEOPLASMS. Part 1. ,at'"lie.errTa7j Experimental Investigatians of the Glycosidic Metabolism in Induced Tobacco smoke has been analyzed for Neoplasms by DMA in Rats.)Cancro cadmium, nickel and lead. From the mean 21(9).e67-300, 1968, Italian rK5g7T values of 8 types of cigarettes, it results that none of the metals reached its MAC- The tumoral tissue shows an increased value in the cigarette smoke inhaled into oxidation speed of citrate and isocitrate the lungs. therefore, one can assume that in comparison with that of noraal tiasue the inhaled amounts of lead are just as of tame age rats. In the same way the little of causal importance to the increased oxidative speed of glucose-6-phosphate com- rate of arteriosclerosis among smoker's as pared with that of 6-phctpho-gluconate is the inhaled amounts of cadmium to pulmonary increased. The enzymatic level of the emphysema. However, with respect to the glucose -6- phosphate dehydrocenase eird discussed hyTert>nic effect of cadmium, the of the phoephogluconic dehydroonase A 11535 (continued) A 11552 (continued) is increased too, not that of the CIGARETTE TAR. Indian Journal of Medical isocitrate dehydrogenase.The skin Research 57(1):1,Jan 1.169. of tumor bearing rats shows a metabolic activity frankly increased in comparison with that of control rats either for A 11553 the oxidation of the added substrate Neukomm, S. or for the enzymatic activity with ACTION OF A CARCINOGENX TAR ON THE the exception of the isocitrate REGENERATION OF THE TAIL OF THE dehydrogenase. (Author Abstract) CRESTED NEWT. Teratology. Excerptia Medica International Congress Series (173). Amsterdam, Netherlands, Excerpta A 11541 Media Foundation, 1969, pp. 11-22. Sapin-Jaloustre, H. CONSEILS AUX FUMEURS. (ADVICE TO SMOKERS.) L'oncours Medical 91(13): A 11556 2730, Mar 2P, 1959, rent (Abs.) Gars, M. and Holland, H. C. CONSOLIDATION AND MAZE LEARNING: A An inquirer, Dr. V---, himself a STUDY OF SOME STRAIN/bRUG INTERACTIONS. smoker, had posed a series of questions PsychopharmacologiA14(5):426-31, 1969. concerning the harmfulness of tobacco and the measures used to reduce its toxicity.In reply, it was stated A 11576 that smoking had an irritant effect Concours Medical. on the respiratory and upper digestive INroxicATIoc TABAGICUE ET VITAM1NE C. tracts and that it was proved that (TOBACCO INTOXICATION AND VITAMIN C.) tobacco favored the development of Concours Medical 91(14):2956, Apr 5, lung cancer and cardiovascular dis- 1969, 1Frer7575s.) orders. The author also summarized the relative hazards of different An inquirer, in a question-and- tobaccos and tobacco products, answer column, had referred to C filtered and unfiltered, and the hypovitaminosie in heavy smokers and relative toxicities of nicotine, had requested some data on the best tars, and carbon monoxide. Inhalation means for measurement of ascorbic acid accentuated the hazards.Total in blood or urine. In reply, it was cessation of smoking was offered as the stated that while tobacco intoxication only sound prophylactic measure. was sometimes accompanied by a deficit Mention was made of the 5-day cures of vitamin C, true scurvy was practically and for further information the never observed, the symptoms being limit- inquirer was directed to Dr. Maud ed to some gingival lesions. An ascorbic Cousin, at Neuilly-sur-Seine and a balance in heavy smokers, however, was book by Wayne MacFarland for thought useful.No fixed constants for detoxication without drugs. ascorbic acid exist and the figures normally given are extremely variable: ascorbic acid in the urine of an adult A 11549 varies between 10 and 40 mg/1; ascorbin- Loveless, A. emia varies between 1 and 16 mg/1 of POSSIBLE RELEVANCE 0? 0-6 ALKYLATION OF plasma. A current procedure for the DEOXYGUANOSINE TO THE MUTAGENICITY AND measurement of ascorburia and aecorbemia CARCINOGENICITY CF NITROSAMINES AND was suggested. NITROSAMIDES. Nature 223(5202):206-7, Jul 12, 1969. A 11584 Bergmann, E. D. A 11550 INTERNATIONAL SYMPOSIUM ON THE Kawamura, H. and Domino, E. F. PHYSICOCHEMICAL MECHANISMS OF DIFFERENTIAL ACTIONS OF m AND n CARCINOOENESIS. Israel Journal of CHOLINERGIC AGONISTS ON THE BRXINSTEM Medical Sciences 577777371577-1&07Apr ACTIVATING SYSTEM. International 196V. Journal of Neuropharmacoloi4 8t2):105- 1-6717111 rm. A 11589 Boletim do Institute Portuguea de A 11552 Oncologia de Francisco Oentil. Reddy, D. G., Reddy, D. B., and Edward, V. CANCERILACAO EXPERIMENTAL PELO TABA00. D. (EXPERIMENTAL TOBACCO CARCINOOENESIS.) EXPERIMENTAL PRODUCTION OF CANCER WITH Boletim do Institute PortugNes de A 11589 (continued) A 11612 Oncologia de Francisco Gentil 392): Gelboin, H. V. 1-14, Feb 17161717o7rtigunT77Cbs. A MICROSOME-DEPENDENT BINDING OF BENZO(a)PYRENE TO DNA. Cancer Research This is a translation of a report by 29(6):r272-6, Jun 1969. E. L. Wynder and D. Hoffmann and has been giveh in its entirety. The subject matter has been presented under the A 11613 following headings:Some characteristics Pinkerton, H., Liu, P. I. S., and of tobacco smoke; respiratory and skin Goodman, E. S. carcinogenesis; ciliotoxic agents; REPRESSION OF BENLO(a)PYRENE carcinogenesis of the bladder; chemical TUMORIGENESIS BY AGENTS PRESENT IN data tumor initiators; tumor-promoting CELLS INFECTED OR TRANSFORMED BY TYPE agents; ciliotoxic constituents of tobacco 12 ADENOVIRUS (33939). Proceediaga smoke; suspect carcinogens; chemical of the Societ for Experimental indicators for the carcinogens; reduction EM MY and Medicine 131(27:621-5, of tumorigenic power; selective and non- Jun 19769. selective reduction; problems of experimental cancerization of tobacco; and future studies. A 11614 Muckter, H., Frankus, E., and More, E. EXPERIMENTAL THERAPEUTIC INVESTIGATIONS A 11595 WITH 1-(MORPHOLINOMETHYL)-4-PHTHALIMIDO- Salver, J. S., Teller, M. N., and FIFERIDINDIONE-2,6 ON DIMETHYLBENL- Balls, M. E. ANTHRACENE-INDUCED TUMORS OF SPRAGUE- CHANGES IN DNA-BOUND AMINO ACIDS IN DAWLEY RATS. Cancer Research 29(6): EXPERIMENTAL TUMOR TRANSPLANTS. 1212-7, Jun 1907-- Cancer Research 29(5):1002-7, May 1969.

A 11615 A 11601 Bernard, P. J., Piette, Y., Delaunois, Horvath, E., Kovacs, K., and Szabo, D. A. L., and De Schaepdryver, A. F. AN ELECTRON-MICROSCOPE STUDY OF THE ACTION OF TOPICALLY APPLIED ATROPINE, ADRENOCORTICAL LESIQN INDUCED BY ESERINE, ACETYLCHOLINE AND NICOTINE 7,12-DIMETHYLBENZ(a)ANTHRACENE IN RATS. ON CORTICAL EPILEPSY IS THE RABBIT. Journal of Pathology 97(2} :277 -82, Feb Archives Internationales de PFERTignaynamie et de Thea"Pie 177(2): 486, Feb T969.

A 11605 Shires, T. X. A 11616 A FLUORESCENCE MICROSCOPIC STUDY OF Luthra, U. K., Bharadwaj, V. p., Lahiri, memoDoLooic EFFECTS ON THE INTRA- V. L., and Wahl, P. N. NUCLEAR DISTRIBUTION OF BENE0(a)- SUCCINIC DEHYDROGENASE ACTIVITY IN PYRENE. Cancer Research 29(6,: D.M.B.A. INDUCED EXPERIMENTAL ORAL 1277-87, CARCINOOENESIS IN HAMSTER CHEEK POUCH. Indian Journal of Medical Research 56(12T:1766-70,716ec 1968. A 11606 Grant, O. A. and Roe, F. J. C. INFLUENCE OF GERM-FREE STATUS ON A 11619 HEPATOMA INDUCTION BY 7,12-DIMETHYLBEN41) Paul, D. ANTHRACENE IN C3H MICE. Nature 222(5200): EFFECTS OF CARCINOGENIC, NONCARCINOGENIC, 1282-3, Jun 28, 1969. AND COCARCINOOENIC AGENTS ON THE BIO- SYNTHESIS OF NUCLEIC ACIDS IN MOUSE SKIN. Cancer Research 29(6):1218-25, A 11610 Jun 19677---- Mc/lvaine, P. M., Nelson, W. C., and Bartlett, D., Jr. TEMPORAL VARIATION OF CARBOXYHEMOG1OBIN CONCENTRATIONS.Archives of Environmental Hes:In-19(1)73-91, Jul 71969.

51 A 11630 A 11667 Noyes, W. F. Rosene, C. J. CARCINOGEN- INDUCED NEOPLASIA WITH COLLABORATIVE STUDY OF A COLORIMETRIC METASTASIS IN A SOUTH AMERICAN DETERMINATION OF NITRATE IN TOBACCO. PRIMATE, SAGUINUS OEDIPUS (33845) Journal of the Association of Official ProceedinITE-FTWe-EFEITEY for 713TICNT raMists 52(4):7-v,M Ex erlmental-91376 and FeifrEine u1707- 7:7233, , May 19677- A 11671 A 11640 Mathe, G. Ziccardi, J. W. ARE THE NEOANTIGENS INDUCED BY A STUDY OF THE IMMUNOLOGIC RESPONSES IN CHEMICAL CARCINOGENS OR BY LEUKAEMO- RABBITS AND C3H/HeJ MICE FROM INJECTION GENIC VIRUSES PARTICULAR TO CANCER CELLS? OF LIVE SUSPENSIONS OF STRAIN MT-70 Transplantation Proceedings 1(1, Part 1) SQUAMOUS CELL CARCINOMA. Journal of the :113-8, Mar 1969. American Osteopathic Association b71917- 104- , y A 11723 Radford, E. P., Hunt, V. R., Little, J. B., A 11645 Wynder, E. L., ani Hoffmann, D. Stanton, M. F., Blackwell, R., and CARCINOGENICITY OF TOBACCO-SMOKE Miller, E. CONSTITUENTS. Science 165(3890):312-3, EXPERIMENTAL PULMONARY CARCINOGENESIS Jul 18, 1969. WITH ASBESTOS. American Industrial Hygiene Associatng-TorFnal 30(3): A 11733 '236 -44, May-Jun 1969. Wiebecke, B., Lohrs, U., Gimmy, J., and Eder, M. ERZEUGUNG VON DARMTUMOREN BEI MAUSEN A 11646 DURCH 1,2-DIMEMLHYDRAZIN.(PRODUCTION Clapp, N. K. and Snyder, F. OF TUMORS IN THE INTESTINES OF MICE BY PRELIMINARY INFORMATION REGARDING THE 1,2-DDMETHYLHYDRAZINE.) Zeitschrift fur OCCURRENCE OF ETHER-LINKED LIPIDS IN die Gesamte Experimentell4F(7) TUMORS INDUCED BY DIETHYLNITROSAMINE. T271757113.9, German (Abs.) Research Report :185-6, 1968. Whereas cancerification of the intestinal mucosa cannot be produced by A 11658 rectal instillation of Dimethylbenz- Giles, J. A. and Curdiff, R. H. anthracene and Benzpyrene, adenomatous COLLABORATIVE STUDY OF THE OLC polyps and adenocarcinomas of the intest- DETERMINATION OF GLYCERINE AND ines develop after subcuteneoua injection PROPYLENE GLYCOL IN TOBACCO. Journal of 1,2-Dimethylhydrazine not only in of the Association of Official-KT:anneal rate but also in mice.With the Mei:rite 51[0:753-67 application of relatively low weekly doses the tumors were limited to the large intestine and only mucosal A 11660 metaplasias appeared in the ileum. Fabro, S. and Sieber, S. M. (Author Abstract) CAFFEINE AND NICOTINE PENETRATE THE PRE-IMPLANTATION BLASTOCYST. Nature 223(5204)1410-1, Jui.26, 1969. A 11735 Utomiya, J., and Mercker, P. C. HATSUGAN BUSSHITSU NO INAI TOYO NI YORU A 11662 RATTO NO TAHATSUSEI NYUOAN (MULTIPLE Saxena, R. C., Dixit, K. S., Dhasmana, MAMMARY CANCERS IN RATS FOLLOWING THE K. M., and Kohli, R. P. INTRAGASTRIC ADMINISTRATION OF CARC10- A SIMPLE METHOD TO MEASURE CENTRAL GENS.)Ochanomizu Igaku Zasshi 16(3): ANTINICOTINIC ACTIVITY. Japanese 35-45,Sep 196e, hp&nege-T577) Journal of pharmacology 19u/a12 -4, Par 1969. A relatively simple end repra4.1eible method of inducing experimental mammary tumors in rats consists of the gastric A 11663 instillation of 3-methylcholanthrenb Hoffmann, D., Rathkamp, O., and Nesnow, S. (either 100 mg in a single dose or QUANTITATIVE DETERMINATION OF 9- multiple doses of 10 mg to a total dose METHYLCARBAZOLES IN CIGARETTE SMOKE. of 210 mg) or a single dose of 15 mg of Analytical Chemistry 41(10):1256-9, 7,12-dimethylbenz(a)anthracene. The Iug 1969.

S2 5' A 11735 (continued) A 11741 (continued) induced tumors are analogous to human OP INDUCING AGENTS ON DRUO-OXIDIZING AND tumors and are hormone-dependent. OTHER REDOX ENZYMES IN LIVER.)Archly fur Pharmakologie and Ex rimentrni-- 1111Tholo ie 263(21:21 -4 , v, erman A 11736 ADS. Harke, H.-P., Frahm, B., and Schultz, C. BESTIMMUNO KLEINER MENOEN NICOTIN UND In rate, the activity of some hepatic COTININ IN TIERISCHEM GEWEBE. redox-enzymes was measured following the (DETERMINATION OF SMALL QUANTITIES OF administration of the enzyme-inducing NICOTINE AND COTININE IN ANIMAL TISSUES. substances phenobarbital, alptla-hexa- Zeitschrift fur Analytische Chemie 244(2 chlorocyclohexane (elphil-HDR-=-S1 6- :119-21, 1907-German (Abs.) benzene hexachlorldiUTDIFT 1201 enyl- diallylacetic acid ester of diethylamino- The method permits the specific ethanol), or 3,4-benzpyrene. In partic- determination of nicotine and cotinine ular, the time course of changes in enzyme in the micro g range in 2 g of tissue. activities was studied. Phenobarbital Nicotine or cotinine are extracted from and alpha-HCH, both enhance the rate of tissue homogenates with ether or chloro- demethilation of amino-pyrine consider- form and are separated from accompanying ably more than they increase the con- substances by thin-layer chromatography. centration of cytochrome P-450. Similarly, The determination is performed spectro- benzpyrene produces an increase in the photometrically by utilization of Konigis rate of hydroxylation of acetanilide that reae,on.The recovery for both compounds ie higher than the increase in con- le 9(,-:5 percent. The procedure ie centration of P-450. especially suitable for investigating questions in connection with the reduction of nicotine by animal tissue. (Author A 11742 Abstract) Kroller, E. UNTERSUCHUNGEN ZUR BESTIMMUNO DES AUS DEM TABAK UNZERSETZT IN DEN RAUCH A 11739 UBERGEHENDEN IHIABENDAZOLS. (INVESTIGA- Holgye, Z. TIONS ON THE DETERMINATION OF STANOVENI 210 -PO V MOCI KOMBINOVANOU THIABENDAZOL FROM TOBACCO PASSING OVER DEPOZICI NA NIKLOVY A STRIBRNY DISK. UNDECOMPOSED IN THE SMOKE,) Deutsche (ESTIMATION OF P0-210 IN URINE BY Lebensmittel;Rundschau 65(3)arlr;--- COMBINED DEPOSITION TO NICKEL AND Mar 1969, Delman (Abs.) SILVER DISC.) Pracovni Lekaretvi 21 (2)162-6, Mar 1017-trrech (Abs.) The fungicide Thiabendazol ie used on tobacco foil of high humidity content Estimation of Po-210 in urine with to avoid mould attack.In order to have combined polonium deposition, gradually a sound judgment on the health aspects to nickel and silver tin-foil enabled of this addition, one should know how determination of polonium in very low much of it is passing over into the concentrations, as well as in great smoke. An analytical procedure has been volumes of urine without mineralization. developed to this end, based upon a color Depoeition to Ni disc is carried out in reaction that allows photometrical maximum from the urine volume of 700 ml determination, but which is also quite after c)ndenaation to 100 ml.Polonium sensitive to interferences by other is desorbed from the Ni disc by concen- smoke ingredients. It has therefore trated nitric acid and deposition of been suggested to use a thin-layer polonium is carried out after treatment chromatographic procedure for the of solution to the silver disc. Volumes separation of the Thiabendazol. of more litres are treated in parts Using this procedure, it has been always to a separate nickel disc. possible to determine, in the smoke Deactivation-solutions are joined and of cigarettes made from tobacco foil the final deposition to one silver disc with 600 ppm Thiabendazol, 120 ppm is carried out.The result of the of this 1111W:erica that has passed over method is 91 percent, VK 3.9 undecomposed. Since according to percent. (Author Abstract) official tobacco regulations up to 20 percent of the tobacco in cigarettes may be tobacco foil, this would mean A 11741 that a smoker absorbs about 24 micro g Korensky, W., Magour, S., Noack, 0., and of Thiabendazol per cigarette, which Hermann, R. S. does not represent Increased health USER DEN EINPLUSS INDWIERENDER dangers. (Author Abstract) SUBSTANZEN AUP PREMDSTOPP-OXYDASEN UND ANDERE RED)XENZIME DER LEBER. (INFLUENCE

S.? A 11757 (continued) A 11756 by 20 percent. Tumors fail to develop Friedrich-Freksa, H., Gossner, W., and in organs which are reached first by the Horner, P. orally applied drugs after their passage HISTOCHEMISCHE UNTERSUCHUNGEN DER through the liver.The tumors localize CANCEROGENESE IN DER RATTENLEBER predominately in the stomach which shows NACH DAUERGABEN VON DIATHYLNITROSAMIN. 70 percent carcinomas (DENA 37 percent). (HISTOCHEMICAL INVESTIGATIONS OF The survival time, tumor frequency and CARCINOGENESIS IN RAT LIVER AFTER tumor localization induced by DENA are CONTINUOUS APPLICATION OF DIETHYLNIMOS- not altered by halothane and methoxy- AMINE.) Zeitschrift fur Krebsforschung fluorane.The drugs differ, however, 72(3):226-34, 1969, German (Abs.) in the type of tumor induced.DENA alone induces hemangioendotheliomas and liver Female rats (Sprague-Dawley) were cancers in a ratio of 26:1. The adminis- periodically injected with one of four tration of halothane changes the ratio doses (2.8 mg/kg to 14 mg/kg) of to 2:1 Methoxylluorane leads to a clear diethylnitrosamine. Almost all liver predominance of epitheliomas to endothe- carcinomas that appeared after months liomas with a ratio of 0.6:1. The total lacked glucose-6-phosphatase as measured dosage of DENA is increased by 7-9 percent histochemically. At all doses clearly perhaps due to the preferential induction delineated islands of cells without of liver epithelial tumors which do not glucose-6-Ohosphatase were observed long lead to early death through hemorrhage. before carcinomas appeared. These islands (Author Abstract) can be distinguished from normal hepatocytes only histochemically. The islands appear at all four dose levels after a A 11758 total amount of diethylnitrosamine between Brune, H., Henning, S., and Schmahl, D. 210 and 260 mg/kg has been administered. DER EINFLUSS VON GLUCOCORTICOIDEN AUF Thus, the first approximation is: C(con- DAS WACHSTUM UND DIE CHEMOTHERAPEUTISCHE centration)X t(time).const. Periodic BEEINFLUSSBARKEIT AUTOCHTHONER BENZPYREN- histochemical examination indicates that SARKOME BEI MAUSEN. (THE INFLUENCE OF glycogen is accumulated in the islands OLUCOCORTICOIDES ON THE GROWTH AND THE lacking glucose-6-phosphatace.This CHEMOTHERAPEUTIC RESPONSE OF AUTOCHTHONOUS glycogen is no longer responsive to SARCOMAS IN MICE.) Zeitschrift fur testing, but usually disappears, later; the Lrebsforschung 72(3):213 -8, I3697-Cerman cytoplasm becomes increasingly basophilic, after which cell divisions become more frequent. With the appearance of an Subcutaneous growing autochthonous atypical cell arrangement, the picture fibrosarcomas induced by 3,4-benzopyrene of the carcinoma is complete. Striking do not change in growing under the in- is the frequent appearance of islands in fluence of Hydrocortisone, Prednisone and a 60 degree sector around the central Dexamethasone. The chemotherapeutic vein. (Author Abstract) effect of cyclophosphamide (Endoxar) on these sarcomas is not reduced but rather increased when applied together with A 11757 glucocorticoiles. (Author Abstract) Kunz, W., Schaude, O., and Thomas, C. DIE BEEINFLUSSUNO DER NITROSAMINCARCINO- CNESE DURCH PHENOBARBITAL UND HALOGEN- A 11768 KOHLENWASSERSTOFFE. (THE EFFECT OF Adamiker, D., Altmann, H., Frischauf, H., PHENOBARBITAL AND HALOGENATED HYDRO- Kellner, O., and Scherbaum, O. H. CARBONS ON NITROSAMINE CARCINOGENESIS.) UBER DIE WIRKUNO VON 7,12-DIMETHYIBENZ(a)- Zeitschrift fur Krebsforschunk 72(3): ANTHRAZEN AU? JIE SYNTHESE DER LACTATDE= 291-304, 5647-German (Abs.) HYDROGENASE-ISOENZNVE IN MENSCHLICHEN FIBROBLASTEN. (THE EFFECT OF 7,12- The administration of phenobarbital DIMETHYLBENL(a)ANTHRACENE ON THE SYNTHESIS and halothane or methoxyfluorane is known OF LACTATE DERYDROGENASE-ISOENZYNEs IN to lead to liver enlargement and enzymatic HUMAN FIBROBLASTS.) Experientia 25(6): and fine structural changes characteristic 590-1, Jun 15, 1959,Berman(Abs.) for each substance. These agents chronic- ally applied to aloino mice show no car- The effect of.7,12-Dimethylbenz(a)- cinogenic effect. They influence however anthracene (DMBA) on the activity or the carcinogenic effect of diethylnitros- lactate dehydrogenase (IDH)-isoenzymes was amine. Phenobarbital increases the total studied in human fibroblast cultures. dosage of DENA needed to cause death by Three isoenzyme components were separated tumor induction as well as the survival by discelectrophoresis. A clear reduction time by 20 percent. The number of in the enzyme activity or the first and ralignant tumors in the liver is reduced third component was observed, while the A 11768 (continued) A 11786 other fraction was little or not affected. Davies, R. F. and Day, I. D. The incorporetion of radioactive amino A STUDY OF THE COMPARATIVE CARCINOGENI- acid in proteins of the LDH- igoenzyme CITY OF CIGARETTE AND CIGAR SMOKE bands shows the game trend, `Author CONDENSATE ON MOUSE SKIN. British Abstract) Journal of Cancer 23(2) :363'8Jixt 1969.

A 11770 A 11787 Jan, F., Jacotot, B., and Beaumont, J. -L. Smith, C. W., Nau, C. A,, and Wender, S. H. PIiENOMENE THROMBO- HEMCRRAGIQUE DECLENCHE PRELIt+INARY STUDIES ON THE FREE PROLINE PAR LA NICOTINE. (THROMHO- HEMORRHAGIC CONTENT OF HeLa CELLS EXPOSED IN VITRO PHENOMENON INDUCED BY NICOTINE.) TO A METHANOL - SOLUBLE FRACTION Pathologie Biologie 17(9 - 10):501 -4, May PARTICULATE MATTER FROM CIGARET E SMOKE. 1969, French 'rAbBj Tobacco 169(4)1204, Jul 25, 1969. Thrombosis and hemorrhage were induced experimentally in the rat by subcutaneous A 11795 infection of carragenine and nicotine. Shatton, J. B., Morris, H. P., and The lesions resembled closely those Weirhouse, S. obtained by Selye by infection of KINETIC, ELECTROPHOR EPIC, AND carragenine and adrenalin.This BeemB CHROMATOORAPHIC STUDIES ON GLUCOSE - to confirm that the phenomenon depends ATP PHOSPHOTRANSFERASES IN RPT at least partly on the liberation of HEPATOMAS. Cancer Research 29(6): catecholaminea. There exist analcgiee 1161-72,Jun 196g. between thrombosis and hemorrhage due to nicotine and certain lesiona of thrombo- angeitie observed in human A 11799 pathology. (Author Abstract) Landaw, S. A. ENDOGENOU° PRODUCTION OF CARBON MONOXIDE: THE HUMAN BODY AS A CAUSE A 11772 OF AIRPOLLUTION. Annale of Internal Saindelle, A,, Ruff, F., and Santaie, M. -C. Medicine7O(6:127,-6 TunT959. LIBERATION D'HISTAMINE PAR LA FUMEE DE CIGARETTE ET CERTAINS DE SES CONSTITUANTS. (LIBERATION OF HISTAMINE BY CIGARETTE A 11800 SMOKE AND CERTAIN OF ITS CONSTITUENTS.) Mody, J. K. Archives Internationales de Pharmacodyn - A NEW TYPE OF TRANSPLANTABLE ADRFYAL ameët de Therap ie 17![27T365 -76, Feo TUMOR AND ITS COMPARATIVE HIS'POPATH- S'JG'g,French(rCs,7 OLOOY. Cancer Research 29(6):1254 -61, Jun 1969. The hydroeoluble part of cigarette Bmoke releases histamine in vitro from chopped guinea -pig and humanTge. This A 11801 property, independent from nicotine, is Schein, P. S. eaBentially due to ethanol. Thie 1- METHYL- I- NITROSOUREA AND DIALKYL- aldehyde releases histamine by a mechanism NITROSAMINE DEPRESSION OF NICOTINAMIDE which ig different from that which is ADENINE DINUCLEOTIDE. Cancer involved in anaphylactic shock, (Author Research 29(6)l226-32,Ji 1969. Abstract) A 11803 A 11780 Balaze, T. Ohtake, S., Cummings, J. R., Fletcher, R. D., Swmey, D. L., Langkamp, and Noble, J. F. H. H., and Platt, D. VENTRICULAR EXTRASYSTOLES INDUCED BY THE ABILITY OF HUMAN SERUM TO AGGLUTINATE EPINEPHRINE, NICOTINE, ETHANOL, AND SHEEP ERYTHROCYTES AND THE EFFECT OF VASOPRESSIN IN DOOS WITH MYOCARDIAL TOBACCO MOSAIC VIRUS. American Review LESIONS.Toxicology and Applied of Respiratory Dieease lOO(T):92-4, 3u1 Pharmacology 15(1r189-'f06u1Z969. P56y .

A 11804 A 11782 Kayaalp, S. 0. and McIeaac, R. J. Lellouch, J., Schwartz, D., and Trans M. H. .4USCARINIC COMPONENT OF SPLANCHNIC- THE RELATIONSHIPS BETWEEN SMOKING AND AI)RPNAL TRANSMISSION IN THE DOG. LEVELS OF SERUM UREA AND URIC ACID British Journal of Pharmacology 36(2): Journal of Chronic Diseases 22 {l)t9 -15, 285-93, 71969. Jun 1969.

33 d4 A 11808 A 11827 (continued) Thompson, J. H., Spezia, C. A., and nitrogen oxides in mice and golden ham Angulo, M. sters in the induction of lung cancers. SEROTONIN RESPONSE TO NICOTINE IN IMMUNOSYMPATHECTOMIZF' MICE.Euro- pean Journal of FharmL.:ology 5Tril- A 11829 39r=3776?-r9SW. Arztliche Praxis. SYMPTOM SCHWINDELGEFUHL. (SENSATION OF DIZZINES$ SYMPTOM.) Arztliche A 11809 Praxis 21(8):425-6, Jan 23777M" Reuber, M. D. and Glover, E. L. Erman (Abe.) THYROIDITIS IN BUFFALO STRATN RATS IN- GESTING 7,12-DIMETHYLBENZ(a)ANTNRACENE. Vertigo can have various causes Ex2eLLE211225(7):753, Jull.5, 1969. including intoxication by nicotine, alcohol, caffein, tetraethyl lead, barbiturates, quinine and other drugs. A 11811 The etiology and symptoms of the dif- Huggins, C., Morii, S., and Pataki, J. ferent types of vertigo were discussed SELECTIVE DESTRUCTION OF ADRENAL CORTEX briefly. BY PULSE DOSES OF DERIVATIVES OF 12- METHYLBEN2(a)ANTHRACENE. Proceedin s of the NatiOhal Acade ofciences A 11637 or En Unites ota ee oMerlon 62r3): Emmelot, P. 7b4:77 RWT7677---- NIET CARCINOGENS SIGARETTEN. (NON - CARCINOGENIC CIGARETTES.) Chemisch Weekblad 64(23):11, Jun 7, i958, A 11819 Dutch tAbe.) Mobbe, B. G. UPTAKE OF (3H)OESTRADIOL BY DIMETHyL- This ie an exchange of correspond- BENZANTHRACENE-INDUCED RAT MAMMARY ence between Dr. Van Juleingha who TUMOURS REGRESSING SPCNTANEOUSLY OR supports the findings of Wynder and AFTER OVARIECTOMY. Journal of Hoffmann concerning the connection Endocrinology 44(3)AM-47-JUT 1969. between smoking and lung cancer and Dr. Emmelot who believes that the causal link has not been satisfac- A 11823 torily established. The basia for Matsuyama, M. and Suzuki, H. the exchange was an article by Van LEIOMYOSARCOMAS INDUCED BY 7,12- Julsingha entitled, "Cigarettes Which PIMSTHYLBENE(a)ANTHEACENE IN GASTRIC Do Not Cause Lung Cancer" which ap- CYSTS GRAFTED-1N SUBCUTANEOUS TISSUE peared in the May 1967 issue of Chemisch OF MICE. Gann 60(3):3334, Jun 1969. Weekblad and Emmelot's own article which appeared in the same Journal several weeks later. In the present A 11827 exchange Emmelot offers his reasons Mediziniache Monateschrift. for differing with Van Julsingha. He DIE PHARMAXOLOOIE DES ZIGARETTENRAUCHSNS. also cites Wynder and Hoffmann's book, (Ira PHARMACOLOGY OF CIGARETTE qmon.) "Tobacco and Tobacco Smoke" in which Medizinische Monateschrift 23(2)151-2, reference ie made to polycyclic aro- FeD 1969, German (Abs.1 matics as initiators and other compounds (phenols) as promoters of the carcino- Pharmacological effecte of nicotine genic process. Emmelot states that or smoking were reviewed The stim- other compounds, still unknown, may be ulating and depressant action of nico- present in the smoke fractions or in tine on the central and autonomic the smoke condensate. In addition, there nervous systems; nicotine content of are strong indications that benzopyrene smoke in relation to puff volume; com- does not function as initiator. He parison of the speed and extent of also commente on the presence of nitrates nicotine absorption by smoking or 1.v. in tobacco and the role of nitrosamines injection of nicotine; effect of 1.v. in the induction of skin tumors in Injection of nicotine on the activity mice. In what he considers the most and cortical activation of trained rate; important point in his letter, he de- effect of nicotine on the activation of plores the nonvalid extrapolation of the cortex and acetylcholine liberation data regarding tumor induction in mouse in smokers; symptoms of chronic nicotine skin (or in connective tissue) to Poisoning in heavy smokers; effect of bronchial carcinoma in heavy smokers. blogenle amines and psychic stress on the liberation of catecholamines from the adrenal medulla of smokers and nonsmokerr; the negative effects of

56 A 11843 A 11850 (continued) De Schepper, p. J. TINE IN THE PRESENCE OF PYRIDINE.) CEWENNINC EN ONTWENNING AAN VERSLAV- Laboratornoe Delo (12):756-7, Dec INGSMIDDELEN. (ACQUIRING AND BREAKING 1968, RussianMs.) DRUG HABITS.) Ti Ceneeskunde 25(,, 1969, Silicotungstic acid used in the Dutch tAbe.) amperometric determination of nicotine does not work in the presence of The general concepts of addiction pyridine. The method described for were defined and the distinctions overcoming this problem consists of between physical and psychic dependency substituting phosphomolybdictungstic were discussed. The dependency char- acid for silicotungstic acid and acteristics, tolerane, psychotoxic adding ammonium nitrate. The method properties and possible psychotic is effective for quantities of up to rlactions upon discontinuance of 0.4 mg pyridine in 1.1 mg nicotine. certain representative drugs (morphine, barbiturates, cocaine, amphetamines, marijuana, LSD, and substances such A 11853 as aspirin, caffeine, nicotine and Laville, Cl. and Margarit, J. alcohol) were given in a table. The SUR LES EFFETS NEUROLOGIQUES CENTRAUX properties of several morphine antag- DU SULPIRIDE. (ON THE CENTRAL onists such as Nallorphine, Penta- NEUROLOGICAL EFFECTS OF SULPIRIDE.) zocine, and Cyclazocine were discussed. Tnerapeutique 45(5):503-7, May 1969, It was stated that coffee, nicotine, French Trtbs.) and LSD result in no physical dependency but cause a very obvious tolerance Sulpiride, in tests with different toward its effects. laboratory animals and with different routes of administration, was round generally inactive in modifying the A 11847 central nervous system action of Cozzolino, G., Latini, p., Dominici, J., mescaline, tryptemine, morphine, Pazzaglia, P. O., and Scianaro, L. tremorine, amphetamine, serotonin and METABOLISMO TRIPTOFANO--ACIDO nicotine. By comparison, chlorpromazine NICOTINICO IN TALUNE AFFEZIONI had greater activity in this respect NEOPLASTICHE. (TRYPTOPHAN-NICOTINIC than sulpiride.To detect the anti- ACID METABOLISM IN SOME NEOPLASTIC convulsive activity of sulpiridine DISEASES.) Annali della Facolta di in mice, its protective activity was Medicine e CM,Mrlidirlr1MTNFriTta studied in crises induced by electric deg11 Studl erygirrffertrirg7 current, pentamethylenetetrazole, Dec Tfrflg/rItalfan (Abs.) nicotine, and auditory stimuli. The tests showed that sulpiride manifested The authors examined 47 patients, no anticonvulsive properties in the some with forms of neoplasia or with mice. metastases, others that had undergone surgery for the excision of neoplasms of various sites. These patients were A 11863 the sample for a study of the behavior Santamaria, L. of the spontaneous daily urinary ex- L'EFFETTO FOTODINAMICO COME MEZZO cretion of some metabolites of tryptophan, DI STUDIO PATOCENETICO DELLA by way of the kynurenines and anthranilic CANCEROGENESI CUTANEA. (THE PHOTO- derivatives. A constant observation DYNAMIC EFFECT AS THE MEANS FOR THE in this study was the decrease in the PATHOGENIC STUDY OF SKIN CARCINOGENESIS.) vrinary excretion of 3-hydroxyanthranilic Minerva Medica 60(31):1518-9, Apr 18, acid for all the types of neoplaaia 1969, ItETIFF(Abs.) examined. Kynurenine also behaves in an irregular way in patients with tumors Tha in vivo and in vitro acceleration or with metastases in various sites. by lightOfWE carciNogilireris in mice (Author Abstract) induced by several polycyclic hydrocarbons (3,4-benzopyrene, 1,2:5,6- dibenzanthracene and 20-methylcholan- A 11850 threne) was reviewed. The author then Polotebneva, N. A. and Krachun, S. V. reported the results of his own experi- NCEPCNETROECKOEONIMEnEWE NMKOTINiA ments carried out on 3 sets of albino, Swiss mice of both sexes treated with BRFVICYTCT81441411 IWA. 3,4-benzopyrene and different intensities AMPEROMETRICHESKOYE OPREDELENIYE of Wood's light. The three experiments NIKOTINA V PRISYTSTVII PIRIOINA. demonstrated that Wood's light and diurnal (AMPEROMETRIC DETERMINATION OF NICO- light influence the carcinogenesie of

57 Loi A 11863 (continued) A 11691 3,4-benzopyrene with phenomena of accel- Gutmann, H. R., Barry, E. J., and eration and inhibition as a function of Malejkagiganti, D. the excitant light. General considera- MECHANISMS OF ACTION OF CARCINOGENIC tions on the experimente seem to AROMATIC AMIDES. Journal of the emphasize the fact that carcinogenesis National Cancer infriniFF On? by 3,4-benzopyrene takes place by p87-91, Jul 1969. processes involving a transfer of energy. In such a case, neoplastic acceleration may be considered as A 11892 evidence of a fundamental mechanism Troll, W., Beaman, S., and Mukai, F. which also takes place in the dark but STUDIES ON THE NATURE OF THE PROXIMAL with reduced velocity. BLADDER CARCINOGENS. Journal of the National Cancer Institute 43(17T2$r5,

A 11886 Dontenwill, W., Harke, H.-P., Lafrenz, U., and Reckzeh, G. A 11893 DIE WIRKUNG VON BENZPYREN, ZIGARETTEN- Deichmann, W. B. and Radomeki, J. L. RAUCHKONDENSAT UND PASSIVER BERAUCHUNG CARCINOGENICITY AND METABOLISM OF AUF DIE BILDUNG DER ZOXAZOLAMINHYDROXYL- AROMATIC AMINES IN THE DOG. Journal ASE. (THE EFFECT OF BENZOPYRENE, of the National Cancer InstiOTT---- CIGARETTE SMOKE CONDENSATE AND PASSIVE 11117263-0, J-u1T9577 SMOKING ON THE INDUCTION OF 40XAZOL- AMINEHYCROXYIASE.)Experientia 25(7): 714-5, Jul 15, 1969, Garman rAbs.) A 11896 Domino, E. F. Treatment with benzo(a)pyrene, A ROLE OF THE CENTRAL NERVOUS SYSTEM cigarette smoke condensatF and IN THE CARDIOVASCULAR ACTIONS OF cigarette smoke on hamsters and rats is NICOTINE. Archives; Internationales able to induce zoxazolaminehydroxylase. de Pharmacodynamie erarTh-ET^a(= Enzyme activity in hamsters is a priori 179117:167-79, May 1-76T7 higher, whereas the enzyme system in rats is 2f higher inducibility. (Author Abstract) A 11897 Dao, T. L. MAMMARY CANCER INDUCTION BY 7,12- A 11881 DIMETHYLBENZ(a)ANTERACENE: RELATION Rosenkrantz, H., Esther, H. J., and Sprague, TO AGE. Science 165(3895):810-1, Aug R. 22, 1969. LUNG HYDROXYPROLINE LEVELS IN MICE EXPOSED TO CIGARETTE SMOKE. Life Sciences 8 (11, Fart 1):571-6, Jun 1, -TVV9. A 11902 Del Carmen Alvarez, M., Del Castillo, J., and Sanchez, V. A 11882 PHARMACOLOGICAL RESPONSES OF THE DORSAL Hancock, J. C. and Voile, R. L. LONGITUDINAL MUSCLE OF SABE1LASTARTE BLOCKADE OF CONDUCTION IN VAGAL FIBERS BY MAGNIFICA. ComparativeMgerira and NICOTINIC DRUGS.Archives Internationales Physiology 20(3)3931-42, Jun 1969. de Pharmacodynamie et de 7herapit 178(1): 1N548, Mar 1969. A 11905 Chouroulinkov, I., Lazar, P., Izard, C., A 11885 Libermann, C., tnd Guerin, M. Engle, C. G. and Groupe, V. "SEBACEOUS GLANDS" AND "HYPERPLASIA" EFFECT OF CHEMICAL CARCINOOENS ON TESTS AS SCREENING METHODS FOR TOBACCO VIRUS-INDUCED RODS SARCOMA. Cancer TAR CARCINOCIENESIS. Journal of the Research 29(7):1345-9, ;Jul 19;177--- National Cancer instinalr4707:7W-5, 771"763.

A 11889 Mallard, J. R. and Kent, M. A 11914 ELECTPON SPIN RESONANCE IN BIOLOGICAL Jull, J. W. TISSUES. Physics in Medicine & MECHANISM OF INDUCTION OF OVARIAN TUMORS INioloSi 14\331543-9T6, Jul 19b9. IN THE MOUSE BY 7,12-DIMETHYLBENZ(a) ANTERACENE.VI. Effect of NormalOvarian TiAsue or. Tumor Development. Journal, of

SB A 11914 (continued) A 11934 (continued) the National Cancer Institute 42(6)067- of losses of glucose-6-phosphatose and 727 Jun 1969. ATpase activities, and of the tisst.e specific antigens of microsomes are found among the various tumors.To interpret A 11917 the results it is assumed that several Lijinsky, W. and Ross, A. E. somat)e mutations are necessary to produce ALKYLATION OF RAT LIVER NUCLEIC ACIDS NOT a live:, carcinoma with DENA. Through RELATED TO CARCINOOENESIS BY N-NITROS- selection, only those mutants accumulate AMINES. Journal of the National Cancer that raise the rate of cell division of Institute77(771r3V-T00, 11=-T'rte677 the hepatocytes, as opposed to lengthening the life-span of the cells. With this assumption one can explain the A 11918 charact tittle localization of the islands Amaral-Mendes, J. J. of cells in a sector of the central vein. HISTOPATHOLOOY OF PRIMARY LUNG TUMOURS (Author Abstract) IN THE MOUSE. Journal of Pathology 97(3):415-27, Mar 1969. A 11936 Kalman, E. A 11924 OSTEOSARKOM VYVOLANY 3,4-BENZPYRENOM. Della Porta, O. and Terracini, B. (OSTEOSARCOMA CAUSED BY 3,4-BENZOPYRENE.) CHEMICAL CARCINOGENESIS IN INFANT ANIMALS. Acta Chirur iae Orthopaedicae et Trauma- Progress in Experimental Tumor Research ae ec oslovaca 11:334-637'1t69. zech lAbs.) The writer presents s description on A 11934 the production of osteosercomas in white Friedrich-Freksa, H., Papadopvlu, O., rats by means of pure crystalline 3,4- and Oossner, W. benzpyrene powder or its combination with HISTOCHEMISCHE UNTERSUCHUNOEN DER CANCER- paraffine. The experimentally produced 00ENESE IN DER RATTENLEBER NACH ZEITLICH osteosarcomas which developed after 6 BEORENZTER VERABFOLGUNG VON DIATHYLNITROS- months were histologically practically AMIN. (HISTOCHEMICAL INVESTIGATIONS OF identical with human osteosarcomas. CARCINOOENESIS IN RAT LIVER AFTER TIME- Their roentgenographic appearance and LIMITED APPLICATION OF DIETHYLNITROSAMINEJ clinical pattern were likewise very Zeitschrift fur Krebeforechung 72(3): similar. (Aubhor Abstract) 240-53, 1969714erman (Aos.)

In two series of experiments female A 11937 rats (Sprague-Dawley) were given period- Giao, N-B. and Buu-Hoi, N. P. ically 8 mg/kg diethylnitrosamine (DENA) EFFETS SARCOMOGENES DE DEUX DERIVES for ton weeks. The controls received 8 AZOTES DU 3,40,10-DIBENZOPYRENE. mg/kg thioacetamide (TAA). After four (SARCOMOOENIC EFFECTS OF TWO NITROGEN weeks islands of cells lacking glucose-6- DERIVATIVES OF 3,489,10-DIBENZOPYRENE.) phosphatase appeared in rats treated with Bulletin du Cancer 55(4)1531-4, Oct- DENA, whereas no islands were found in rerring,lwriCETerAbs. ) IAA-treated rate even after ten weeks. In contrast, both agents cause clear areas Two nitrogen derivatives of 3,4:9,10- around the central vein which then disap- dibenzopyrene, 5-amino- and 5-nitro-3,41 pear a few weeks later. In one series 9,10-dibenzopyrene, proved sarcomogenic female rate received 8 mg/kg DENA daily for or, subcutaneous injection in the mouse. one week.The animals were then examined The amine zompound is more active than after prolonged intervals. Even Etter 210 the nitrous compound but both are much days several islands were found, indicating more active than 3,419,10-dibenzopyrene a total dose of 56 mg/kg is sufficient to itself. (Author Abstract) form islands that remain. In one animal a micro-carcinoma was found. In a second series DENA was administered at 8 mg/kg A 11938 for eight weeks trld then stopped to in- Delwaide, P. A. vestigate the growth of the islands after EllIDES SUR L,ACTION BIOLOGIQUE DU remission of reversible changes. For BENTIPYRENE--III. LOCALISATION DU five weeks the islar.Js did not grow but BENG PYRENE TRITIE CHEZ LE RAT APRES then suddenly turn into carcinomas. His- ADMINISTRATION INTRAPERITONEALE. (STUDIES tochtmical reactions with a carcinoma are ON THE BICLOOICAL ACTION OF BENZ(a - generally uniform, but usually different PYRENE--III. LOCALIZATION OF TRIrIATED from carcinoma to carcinoma, also within BENZO(a)PYRENE IN THE RAT AFTER the same animal. All possible combinations

59 103 A 11938 (continued) A 11946 (continued) INTRAPERITONEAL ADMINISTRATION.) INDUCED BY HYDRAZINE.) Lavori Biochemical Pharmacology 18(6):1275-83, dell'Ietituto di Anatomia e Junn69, French (Abe.) 1-6171c7rilfirongnlitrnlVeFalta degIl gtudl Perusla 29(1):0=41", The distribution of tritiated 1969, TraTian kAbs.) benzo(a)pyrene in rat liver, kidney, adrenal", spleen, testicle and heart was The spontaneous incidence of lung studied between 1/2 -24 hr. after intra- tumors is low in intact virgin and peritoneal injection, with and without gonadectomized CBA/Cb/Se mice of simultaneous administration of a large both sexes. High daily doses of dose20 mg/kg) of nonradioactive hydrazine sulphate (h.s.) increased benzo a)pyrene.Intracellular distribu- the incidence as follows: intact tion in the liver was similarly studied. virgins: males 7E percent, females In all cases, measurements were obtained 90 percent; gonadectomized: males of total radioactivity and of petroleum 72 percent, females 80 percent. ether extractible radioactivity H.s. given in smaller doses is more (corresponding to unmetabollzed benzo(a)- active in female than in male intact pyrene). While tissue concentrations virgin mice, while the lung tumor were maximal 4-6 hr. after injection, no incidence le higher in gonadectomized clear-cut organ specificity could be mice than in the untreated controls demonstrated either for levels of but the difference between the sexes benzo(a)pyrene or for the pattern of practically disappears.Daily doses distribution between unchanged hydr,- of 0.56 mg of h.s. gave 87 percent carbon and its metabolites. A small of lung tumors in intact female fraction (5 percent) of the initial dose virgins and 20 percent in intact was localized in the liver. In the virgin males; 0.28 mg daily gave subcsllular fractions, microsomal 50 percent and 16 percent respec- localization was considerable at first; tively, and 0.14 mg daily 40 percent activity then increased steadily in and 7 percent. The lung tumor inci- the supernatant, where it was found in dence in gonadectomized mice was 28 the form of nonextractible metabolites. percent in females and 21 percent in (Author Abstract) males with 0.45 mg daily, 24 percent and 11 percent respectively with 0.28 mg daily and 8 percent and 12 percent A 11943 with 0.14 mg daily. These results Rondia, D. and Delwaide, p. give reason to think that a hor- ETUDE DE L'ACTION BIOLOGIQUE DU BENZO(a)- monal factor may be involved in PYRENE--II. METABOLISATION DE DIVERS pulmonary carcinogenesls by hydrazine HYDROCARBURES POLYCYCLNUES PAR LES sulphate in CBA/Cb/Se mice. (Author ENZYMES HEPATIQUES AVAhT ET APSES Abstract) INDUCTION PAR LE BENZO(a)PYRENE. (STUDY OF THE BIOLOGICAL ACTIOfT OF BENZO(a)- PYRENE--II.METABOLISM OF VARIOUS A 11948 POLYCYCLIC HYDROCARBONS BY HEPATIC Mantel, K. and Farber, D. ENZYMES BEFORE AND AFTER INDUCTION BY VERGIFTUNGEN IM ERSTEN LEBENSJAHR. BENZO(a)PYRENE.1Biochemical (POISONING IN THE FIRSTYEAROF PharmaZology 18((6):1269 -74, Tun 1969, LIFE.)MonatsachriftfurKinder- French (Abe.) heilkunde 1174):193-57-gpr 1969, MFEEFrbs.) The rate of metabolism of polycyclic hydrocarbons by rat liver homogenates is Seventy-two cases of accidental independent of the physical characters of poisoning (16 by ingestion of cig- the molecules. After stimulation of the arettes) were observed in infants liver enzymic systems in the rat by below the age cf one year in two benzo(a)pyrene these rates are character- children's hospitals in Munich from istically increased for the various com- 1962 to 1966. The reasons for the pounds. This suggests the existence of infants' inability to tolerate the several metabolic pathways for each com- poisons were given astenzymatic pcoand, some of which could be non- immaturity of the microsomal enzymes induceable. (Author Abstract). of the liver and of the enzyme systems of the erythrocytes; transitory hyper- protelnemla; abnormal vascular per- A 11946 meability; reduced efficiency of the gianclflorl, C. excretory function of kidneys and ESISTFNZA DI UN FATTORE ORMONICO llver; raised hemoglobin enzyme levels; NELLA CANCEROGENESI POLMONARE DA relatively large body surface in IDRAZINA. (EXISTENCE OF A HORMONAL comparison with weight) and peculiar- FACTOR IN PULMONARY CARCINCOENESIS ities of the metabolism of the infants. A 11948 (continued) A 11956 (continued) The pharmacological action of nicotine with the duration of the smoking habit was not specified.Some general guide- nor with the number of cigarettes lines for preventing such accidents smoked.The proportion of mobile cella were also presented. was also reduced and was dependent upon.the number of cigarettes 'smoked. The incidence of pathological forms A 11955 reached high valuea only in cases with Elmenhorat, H., Stadler, L., and large 'doses" and long-continued smoking Ooertz, E. abuse. Smoking thus exerted an unfa- FRAKTIONIERUNG VON CIGAREWENRAUCH- vorable influence on spermatogenesis KONDENSAT. II. Gelfiltrationschrom- and this influence, according to ex- atogrtfifi von Fluoreszierenden perience with animal studies, was at- Inhalteatoffen Einer Waaserloelichen tributed to the hindrance of cell Fraktion aus Cigarettenrauchkondensat. division. (FRACTIONATION OF CIGARETTE SMOKE. CONDENSATE. II. Gel Filtration Chromatography of the Fluorescing A 11961 Components of a Water-Soluble Fraction Devya, M., Alcaide, A., and Barbier, M. of Cigarette Smoke Condensate. BIOSYNTHESE DU CHOLESTEROL A PARTIR Journal of Chromate a 40(2i:264-9, DU CYCLOARTANOL PAR LE TABAC NICOTIANA F7'2137115'07,717- n s.) TABACUM. (BIOSYNTHESIS OF CHOLESTEROL FAUFMITOLOARTANOL BY TOBACCO NICOTIANA The fluorescing components of the TABACUM.) Bulletin de la socrEt-F73F-- water-soluble fraction of cigarette Ctifriren3tiologi/T)1733873ixn smoke condensate were separated by ing,-17rench kAbs.) chromatography on Sephadex gel. Thin- layer chromatographic investigations The leaves of Nicotiana tabacum of the subtractions obtained dem- have been impregnated with a sou on onstrated that the fluorescence of of cycloartanyl acetate tritiated in the water-soluble part of cigarette the aide chain. We have isolated a smoke condensate is due to the sub- mixture of sterol's in which the only stances acopoletln, harman, norharman labeled compound ie cholesterol; (in- and at least 22 additional aubetancea corporation yield 0.6 percent). Our which occur in lesser quantities and experiment shows that higher plants which have not yet been identified. are able to synthesize cholesterol Scopoletin and the mixture of barman from a triterpenic alcohol such as and novh.-..rman wore separated from the cycloartanol. (Author Abstract) other fluorescing substances by gel chromatography. In the different sub- fractions, nicotine, nicotine-N-oxide, A 11967 nicotinic acid as well as 17 other sub- Champy-Hatem, S. stances which react positively with LA REACTION irIMIDAZOLES--BENZO-3,4- BrCN/benzidine and which have not yet PYRENET, SON RETENTISSEMENT SUR LA FOR- been completely identified, were found MATION DES ACIDES NUCLENCES ET SUR in the form of nonfluorescing compo- LEUR FUNCTION. (THE "IMIDAZOLES-- nents. These substances can also be 3,4-BENZOPYRENE" REACTION, ITS REPER- partly separated from each other by gel CUSSION ON THE FORMATION OF NUCLEIC chromatography.Therefore, chromato- ACIDS AND ON THEIR FUNCTION.) Bulletin graphy on Sephadex gel appears to be a de ',Academie Nationale de MedenToi---- useful procedure for fractionating 5 5 319-101:146-57RWTI96 T7 FFMEErAba.) water-soluble components of tobacco smoke condensate. (Author Abstract) The imidazole-carcinogen (3,4- benzopyrene) reaction was tested at different aaidities; the reaction was A 11956 clear in the alkaline range, very Viczian, M. clear at the pH of tissues but not ERGEBNISSE VON SPERMAUNTERSUCHUNGEN evident at pH 3. One observes that in BEI ZIGARETTENRAUCHERN. (RESULTS OF an acid medium, where the basic nitro- INVESTIGATIONSOF SPERMIN CIGARETTE gen cannot respond to the carcinogen, SMOKERS.) leitschriftfur Hautund the reaction is not apparent. The Oeschlachten'IT(STET8377, imidazole reaction was negative with Mar 1, 1969, Oerman tabs.) the noncarcinogenic isomer, perylene. With 21ethylimidazole, where the Cigarette smoking caused a mea- methyl group sensitizes the basic surable reduction in the number of function of the imidazole, the reac- sperm cella. This reduction in the tion with the carcinogen under the total number of cells was not parallel same conditions was feeble, but A 11967 (continued) A 11977 apparent. With N-methylimidazole Pylev, L. N. (with blocked acid nitrogen) and under monmonorviubEcKvbE113MEHE14 WA DErKlIKH KPUC the same conditions, the reaction with A PE3YI1'TATEVUE11461A KMAJPHOW MOM C the carcinogen waa violent. In the AaCCPSAPCNVMM HA HEU 3,4-SD-I3-4PE:WI. presence of 3,4-benzopyrene and non- MORFOLOC ICHESKIYE ILMENENIYA V LEOKI:11 carcinogen, the N-methyllmidazole KRYS V REZUWTATE WEDENIYA KANAL'NOY selected the carcinogen and remained SAZHI S ADSORBIROVANNYM NA NEY 3,4- insensitive or less sensitive to the BENZPIRENOM. (MORPHOLOGICAL CHANGES other compound. The imidazole-carcinogen IN LUNGS OF RATS AS A RESULT OF INTRO- reaction was more pronounced in a bio- DUCTION OF CHANNEL BLACK WITH ABSORBED logical than an aqueous milieu. It 3,4-BENZOPYRENE.)Gigiena i Sanitariia thus appears that in the presence of a 34(2):102-4, Feb 1965, RussTan (Abs.) carcinogen, a reaction, in which the basic nitrogen of the imidazole has the To investigate a suspected relation initiative, creates a disorder in the between pneumoconiosis and cancer of "information library' which can inter- the lung, particularly in mine workers, vene in the genesis of nucleic acids an experiment was carried out in which and can perpetuate itself. 3,4-benzopyrene absorbed on channel black was administered intratracheally to 68 rats in 6 doses each of 0.1 mg A 11973 34-benzopyrene to 10 mg channel black. Izard, C., and Valadaud, D. Fifteen control rats received a single SUR L'OBTENTION D'UN CLONE DE dose of 0.6 mg 3 4- benzopyrene. The DUNALIELLA BIOCULATA ACCOUTUME rats were sacrificed one day after ad- LA PHASE 0AZE1f5t rt FUMEE DE ministration of the test substances and CIGARETTE ET SUR SON COMPORTEMENT a microscopic examination was made of EN PRESENCE DE 4-NITROQUINOLEINE- their lungs. The results show that N-OXYDE ET DE 4-NITROQUINALDINE- 3,4-benzopyrene absorbed on channel black N-OXYDE. (ON OBTAINING A CLONE is capable of bringing about changes OF DUNALIELLA BIOCULATA CONDITIONED in lung tissue which may lead to precan- TO THE GAS PRASE7PVMARETTE cerous conditions.Channel black alro SMOKE AND ON ITS BEHAVIOR IN THE prolongs the retention of 3,4-benzopyrene PRESENCE Cie 4-NITROUINOLINE-N- in the lungs. OXIDE AND 4-NITROZUINALDINE-N-OXIDE.) Com tes Rendus Hebdomadaires des eances FrITrcademit des Sciences; A 11976 617sTices Naturelles 2"6"73(17Frr,s D) Hamburger, F. and Baker, J. R. T35-8, 777767-Yrench (Abs.) ACCELERATED CARCINOGEN TESTING. Progress in Experimental Tumor A clone of Dunaliella bioculata, Research 1r:584-94, 1969. resistant to thrEFET775fFIFFEEre smoke was obtained. The clone, after having shown a certain resistance to the A 11982 two carcinogens, 4-nitroquinoline-N-oxide Napalkov, N. P. and Pozharisski, K. M. and 4-nitroquinaldine-N-oxide, then MORPHOGENESIS OF EXPERIMENTAL TUMORS became more sensitive to the two OF THE ESOPHAGUS. Journal of the carcinogens. The thiol-depriving National Cancer Institute 4/TOT727-40, activity of trw gas phase was then Jun 1969. confirmed. Under conditions of the experiment, cysteine completely annulled the toxIxity of the gas A 11985 phase. A clear competitive action Jull, J. W. between cysteine and 4-nitroquinoline- MECHANIS4 OF INDUCTION OF OVARIAN TUMORS N-oxide was observed.No protective IN THE MOUSE BY 7,12-DIMFTHYLBENZ(a)- action however was observed with tr ANTHRACEIE. V. Effect of Metabolic tryptophan and 4-nitroquinoline-N-oxide. Inhibitors. Journal of the National On the contrary, a slight positive effect Cancer Institute 42(67T9tn, Jun 1969. with respect to the gas phase was observed. A 11986 Williams, R. G. and Woodcock, S. R. A 11975 THE DIAGNOSIS AND MATNENT OF MOUPH Hull, E. W., Carbone, P. P., Gitlin, D., CANCER. British Journal of Oral O'Gara, R. W., and Kelly, M. G. Surgery 613):181-7, Mar 1759. ALPHA-FETOPROTEIN IN MONKEYS WITH RETKIbmA. Journal of the National Cancer Institute 42rniT535-44, Jun 1969. A 11987 A 11999 L'vitsyna, G. M. end Shishkin, V. F. Pipkin, G. E., Schlegel, J. U., Nishimura, RECfl6TCON1UPECIOLE CERmallaUXECKPIE PEAKTCVN 1JP0 R., and Shultz, O. N. flOpA3XD141 OPTWP3 4A1100014,611-210. INHIBITORY EFFECT OF L-ASCORBATE ON NESPETSIFICHESVIYE SEROLOOICHESKIYE TUMOR FORMATION IN URINARY BLADDERS REAKTSII PRI PORAZHENII OROANIZMA IMPLANTED WITH 3-HYDROXYANTHRANILIC POLONIYEM-210. (NONSPECIFIC SEROLOGICAL ACID (33916). Proceedings of the REACTION IN ATTACK OF THE ORGANISM WITH Society for Experimenter BiBTo-rvand POLONIUM-210.) Fcitobiologiia 9(3): medicine-M12):5224-, Tun 1969. 388-92, May-Junrro-,Russian (Abs.) For the determination of specific A 12000 serological reactions in guinea piga Bertalanffy, F. D. following the fc.troduction of polonium- COMPARISON BETWEEN THE RATES OF 210 (5 microcuries/kg of body weight) PROLIFERATION OF INDUCED MALIGNANCIES into the body cavity, three grcupa of AND THEIR NORMAL TISSUES OF ORIGIN. animals were tested: 1) treated with Recent Results in Cancer Research emulsion of Breslau vaccine one month 17:136-46, 1969. before the introduction of polonium- 210; 2) treated with Breslau vaccine two weeks after introduction of polonium- A 12007 210; and 3) unvaccinated animals.The Bryan, O. T. serum antibodies to the Breslau vaccine, PELLET IMPLANTATION STUDIES OF and to tetravaccine and brucella diag- CARCINOGENIC COMPOUNDS. Journal nosticum were then determined. Intro- of the National Cancer Institute duction of polonium-210 caused th.: rs(r7T255 -61 71.11-117613. manifestation of serological reactions in 56 percent of the animals. In animals vaccinated before introduction A 12010 of the polonium, the nonspecific reac- Bendich, A., Borenfrdund, E., Honda, Y., tions were numerically 5 to 10 times and Steinglass, M. higher, and in animals vaccin.ted two CELL TRANSFORMATION AND THE GENESIS OF weeks after introduction of polonium, CANCER. Archives of Environmental they were 2 to 5 times lower, than in Health 19TE1775776g7 AvA 196. the unvaccinated animals.

A 12011 A 11991 Ranadive, K. J., Oothoskar, S. V., and Kantemir, I. Fernandes, O. TESTS ON THE EXPERIMENTAL INDUCTION OF A NEW INBRED STRAIN OF MOUSE C17/Icre CANCER. Acta Medica Turcica 6(1):3-10, DEVELOPED FOR TESTING WEAK CARCINOGENS. 1969. Indian Journal of Medical Research g70):521777Wingr77---

A 11995 Naughton, O. and Nash, D. R. A 12012 TRANSPLANTATION ANTIOENS AND VIRAL Greaser, I., Bourali, C., Levy, J. P., CARCINOOENESIS. Progress in Medical Fontaine-Brouty-Boye, P., and Thomas, M. T. Virologx 11:248-906, 1969. INCREASED SURVIVAL IN MICE INOCULATED WITH TUMOR CELLS AND TREATED WITH INTERFERON PREPARATIONS. Proceedings A 11996 of the National Academy of sciences of Reiskin, A. B. tre-Vntermgares of KineMi7T1TrIM77, CELL PROLIFERATION DURING CARCINOGENESIS. lu-17 1969. Recent Results in Cancer Research 17:128- 35, 19677- A 22020 Gothe, C. -J., Fristedt, B., Sundell, L., A 11997 Kolmodin, B., Ehrner-Samuel, H., and Borum, K. Clothe, K. DMBA SKIN CARCINOGENESIS IN ADULT MICE CARBON MONOXIDE HAZARD IN CITY TRAFFIC. THYNECTOMIZED AT BIRTH. AnLIali Italiani Archives of Environmental Health 19(3): di Dermatologla Clinics e-VITFrmentaie 31 o-T; gen 7617---- (4)1371-4, 19617--

63 A 12Ce2 A 12045 Grant, G. A. and Roe, F. J. C. Neurath, 0. and Danger, M. EFFECT OF GERM-FREE STATUS AND ISOLIERUNG SCHWACH BASISCHER ANTILYMPHOCYTE SERUM ON INDUCTION OF HETEROAROMATEN AUS DEM TABAKRAUCH. VARIOUS TUMORS IN MICE BY A CHEMICAL (ISOLATION OF WEAK BASIC HE 0- CARCINCOR. GIVEN AT BIRTH.Nature AROMATICS FROM TOBACCO SMOKE.) 223(5210)31060, Sep 6, 1969. Beitrage zur Tabakforachung 5(1)31 -4, Jun I969,71Frman (Abs.)

A 12023 From the smoke of normal blend Schmid, F. A., Elmer, I., and Tarnowaki, cigarettes the weak heteroal-matic G. S. bases with pKa values below 5 have GENETIC DETEHMINATION OF DIFFERENTIAL been isolated by steam distillation INFLAMMATORY REACTIVITY AND SUBCUTANEOUS followed by precipitation of the TUMOR SUSCEPTIBILITY OF AKR:J AND C57BL/ barn with hydrochloric acid from 6J MICE TO 7,12-DI METHYLBENZ(a)ANTHRACENE. ethereal solution.2,3-dimethyl- Cancer Research 29(8)11585-9, Aug 1969. pyrazine, 2,5-dimethylpyrazine, trimethylpyrazine, 2-methy1-6-ethylpyrazine, 2,6-diethylpyrazine, a A 12Ce4 dimethyl-ethylpyrazine, tetramethyl- Toth, B. pyrazine, and a methyl-furylpyrazine, THE INDUCTION OF MALIGNANT LYMPHOMAS AND 2-phenylpyridine, 3-phenylpyridine, OTHER TUMORS BY 7,12-D7METHYLBENZ(a)- two methylquinolines, and three ANTHRACENE IN THE SYRIAN GOIDEN HAFfsTal. clImethylquinolines have been identified Cancer Research 2900:1476-64, Aug 1969. in tobacco smoke for the first time. Furthermore, 3-vinylpyridine, 3-Cyano- pyridine, quinoline, 2,3'-dipyricyl, A 12028 skatol, 2-methyl -5-formylfuran, and a Zielonka, B., Chrzan, H., and Hryeak, T. methylbenzofuran have been found. KOLORYMETRYCZNE OZNACZANIE CUKROW (Author Abstract) FEDUKUJACYCH (PO KROTKIEJ INWMRSJI) W TYTONIU ZA POMOCA 2,4-DWUNITROFENOLU (DNP). (COLORIKETRIC DETERMINATION OF A 12046 REDUCING SUGARS (AFTER SHORT INVEAEION) Schlotzhauer, W. S. and Schmaltz, T. IN TOBACCO WITH 2,4-DINITROPHENOL PYROGENESIS OF AROMATIC HYDROCARBONS (DNP).) ChemiAbsa Analit czna 14(3)t573 -9, PRESENT IN CIGARETTE SMOKE II. Pyrolytic 1969, Polish (. Products or Some Representative Con- stituents of the Hexane Soluble Fraction Photocolorimetric method for determi- of Tobacco.Baitra e zur Tatakforschung nation of reducing augers in tobacco after 5(1):5-8,Junl . short inversion, based on col=a reaction with DNP has been elaborated. The aqueous extract of tobacco is depruttinated A 12047 thermally. After short inversion in the Kruszynaki, A. J. end Henriksen, A. presence of concentrated HCL, 2 ml of DIE QUANTITATIVE BESTIAD1WG VON sample is mixed with 6 ml of reagent KOHLENMONOXID IM TABAKRAUCH. (THE (DNP) solution, boiled 6 minutes on a WANTITATIVE DETERMINATION OF CARFAN water bath, and cooled 3 minutes In a MONOXIDE IN TOBACCO SMOKE.) Beitrage stream of a cool tap water. The zur Tatakforsohung absorbance of a colored solution is GertrAn (Abb.) measured with the aid of a photocolor- 'meter and a reroent contents of Carbon mc,loxide is found in the gas carbohydrttes is read from analytical phase of cigarette smoke in relatively curve. Statistical analysis has shown high quantities. In the present study a that there, is no significant difference quantitative method for the determination between the results obtained with the of carbon monoxide in tobacco amcke by photocolorimetric and Bertrand's method. gag chromatography was used. The con- There is no syetematic error in the struction of a calibration line by means photocolorimetrio method and random error of carbon monoxide produced in the is smaller than that in Bertrand's method. laboratory is indicated and the experi- The elaborated method is simple and yields mental procedure is deacribed. Further- reproducible results; the method is more more the relation between the carbon rapid than other methods being in use in monoxide content in smoke and different the food industry and can be recommended parameters of the test cigarettes is or research end testing laboratories. evaluated. The carbon monoxide content (Author Abstract) in the smoke of various tobacco blends is

64 tog A 12047 (continued) A 12050 (continued) determined.An increase of the eurbon monoxide content in the smoke is observed The possibilities of determining after the extraction of sugars from the various anions of the burning additives tobacco.The carbon monoxide content in cigarette paper are described.The increased from puff to puff when the use of the flame - photometric method is cigarettes were smoked. Cigarette weight recommended for the determination of the had no influence on, carbon monoxide in quantity of the burning agents and the smoke. This applies also to the for deciding whether these are present humidity of the tobacco, the acetate as sodium and/or as potassium compounds. filters t..nd the carbon filters. Puff (Author Abstract) volume and the perforation of cigarette paper, however, influenced the carbon monoxide yield considerably. (Author A 12061 Abstract) Jodl, R. USER DEN EINFLUSS DER GLIMMSALZE DES CIGARETTENPAPIERS AUF DIE A 12048 ABRAUCHERGEBNISSE VON CIGARETTEN. Stedman, R. L., Lakritz, L., and Strange, (THE INFLUENCE OF BURNING ADDITIVES E. D. OF CIGARETTE PAPER ON THE YIELDS COMPOSITION STUDIES ON TOBACCO XXXIII. OF SMOKED CIGARETTES.) Eeitrage zur CHANGES IN SMOKE COMPOSITION AND TabeciorachtlIgu 5(1 )322-477ir-1706§-7 FILTRATION BY ARTIP:.:AAL ALTERATION OF FFMTLFFP.T1.7r SMOKE pH: Pyridine and Nicotine. Beitrage zur Tabakforaehung 5(1):13-7, The burning rate of a defined ciga- Jun 1969. rette blend -- same kind and composition of the cut tobacco assumed -- depends upon the porosity of the rper as well as A 12049 upon the type and quantity ,f the burning Aksu, S. additives of the paper. If the same EINIGE ORGANISCHE SALE ALS burning agent is added in comparable FEUCHTHALTEMITTEL IN CIGARETTEN. amounts the burning rate varies according (SOME ORGANIC SALTS AS HUMECTANTS IN to the porosity of the paper. In the CIGARETTES.) Beitrage zur Tabakforschung smoke, total condensate and nicotine 5(1):18-9, Jun 1959, Zeman (Abs.) decrease with an increasing burning rate. (Author Abstract) Sorbitol and diethylene glycol were compared with the respective effects of potessiu1 acetate, potassium lactate, A 12052 magnesium acetate and potassium malate Elmenhorst, H. and Hennig, W. as humectants for a Turkish tobacco blend. EINE VOLLAUTOMATISCHE RAUCHMASCHINE. Potassium lactate and magnesium acetate II. Mitteilung: Automatische Kontrolle resulted in a slight improvement of taste der Stummellange and Ihre Verwendung ale while scrbitol was a little unfavorable Steuerprinzip. (A COMPLETELY AUTOMATIC in this respect.In the cigarettes with SMOKING MACHINE. Report III Automatic sorbitol and diethylene glycol the yield Control of the Butt Length and its of condensate per cigarette was slightly Application as Control Principle.) increased.The selts of potassium caused Beitre e zur Tabakforschuna 5(0:25-7, an increase in burning rate.Potassium ,Wrinan (Abs.) acetate, potassium lactate, magnesium acetate, potassium malate and sorbitol A device for the automatic control increased the filling power. There was of butt lengths which can be attached no evidence that the :+rgetnie salts, which to the automatic smoking machine is were investigated e%ould not be used its described.The system controls the hummetants in the industrial production length of butte by measuring the of tobacco goods. (Author Abstract) infrared radiation of the glowing zone of the burning cigarette and releases the automatic ejector of butts when the re- A 12060 quired length has been reached. The Jodi, R. system is adjustable for any length of UBER DEN NACHWEIS CND DIE BESTIMMUNG VON butte. It is shown that the precision' GLIMMSALZEN IN CIGARETTE4pAPIEREN. of the smoking procedure of the fully (THE DETECTION AND DETERMINATION OF automatic emoking machine is considerably BURNING ADDITIVES IN CDARETT4 pAPER.) improved by the described control system. Beitra e zur TabakforSchunA 5(1)120-1, E'en with cigarettes of nonhomogeneous un Carman (Ape.) quality and with difference in burning,

i9 A 12062 (continued) A 12095 rates it should be possible to smoke, Boren, H. O. these automatically and according to SEQUENCE OF EXPOSURE TO ENVIRONMENTAL CORESTA standards, if this new device AGENTS AS A DETERMINANT OP PULMONARY for the control of butt length ie used. INJURY. In Proceedings of the Tenth (Author Abstract.) Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in Chronic Obstructive Lung A 12063 Disease. U. S. Department of Health, Erxleben, E. and Vorwerk, A. Education, and Welfare, Public Health MESSUNO DES ZUGWIDERSTANDES VON Service, Washington, D.C., public Health FILTERSTABEN UND DUSEN UNTER Service Publication No. 1787, 1968, VERSCHIEDENEN LUFTDRUCKBEDINGUNGEN. pp. 395-410. (MEASUREMENT OF THE DRAW RESISTANCE OF FILTER RODS AND NOZZLES UNDER DIFFERENT AIR PRESSURE CONDITIONS.) Beitrage zur A mole Tabakforschung 5(1):28-33, Jun 19E9, Connecticut Medicine. Dorman Tabs.) DRUG METABOLISM AND THERAPEUTICS. Connecticut Medicine 33(7):430-2, The relations between the pressure Jul 1969. drop values of filter rode and nozzles obtained by customary gauges and the atmospheric pressure are investigated. A 12108 Measurements are carried out between 500 Takayama, S. and Imaizumi, T. and 1,000 mm Kg external pressure. This SEQUENTIAL EFFECTS OF CHEMICALLY range was produced artifically.In the DIFFERENT CARCINOOENS, DIMETHYL- case of filter rods it ie shown, that NITROSAMENE AND 4-DIMETHYLAMINO- a variation of 4 percent only is received AZOBENZENE, ON HEPATOOARCINWENESIS on the full measuring range by operating IN RATS. International Journal at constant air circulation (cubic centi- of Cancer 4'(Z)7373.71337311rT571969. meters/e) independent of atmospheric pressure. This shift la negligible in view of normally- occurring Meal varia- A 12109 tions of atmospheric pressure,By Morena., D. R., Oruenatein, M., and operating at constant air circulation Shimkin, M. B. (cubic centimeters/8) the value of the noz- EFFECT OF AGE AND SEX ON THE DEVELOPMENT zles' pressure drop varies in considerable OF NEOPLASMS IN WISTAR RATS RECEIVING degree over the full measuring range. A SINGLE INTRAOASTRIC INSTILLATION OF Using reference nozzles for devices of 7,12-DIMETHYLBEiZ(a)ANT'HRACENE. pressure drop determination at different International Journal Cancer 4(4): altitudes therefore, either a correction 480-5, Jul l.3', 3 of the reference mark fixed at a standard pressure ie necessary, or the values for filter pressure drop are to be corrected. A 12112 The corrections are indicated. (Author Pedersen, T. and Krarup, T. Abstract) CELL F9PULATInN KINETICS IN THE MOUSE OVARY AT TREATMENT WITH A CHEMICAL CARCINOGEN (DMBA). International A 12089 Journal of Cancer 4(TrinZDT7lul Woolcock, A. J., Macklem, P. T., Hogg, J. C., 117-17TO. Wilson, N. J., Nadel, J. A., Frank, N. R., Brain, J. THE RESPONSE OF CENTRAL AND PERIPHERAL A 12113 AIRWAYS TO VAOAI. STIMULATION IN DOGS. Armitage. A. K. and Hall, O. H. Inc Proceedings of the Tenth Aspen MODE or ACTION OF INTRAVENOUS NICOTINE IN Emphysema Conference, Aspen, Colorado, CAUSING A PALL OF BLOOD PRESSURE IN THS Jun 7-10, 1457, Current Research in CAT, European Journal of Pharmacolo Chronic. Obstructive Lung Disease. 7(1)t23-3O, U. S. Department of Health, Education, and Welfare, Public Health Service, Washington, D.C., Public Health Service A 12114 Publication No. 1787, 1968, pp. 275-85. Dalhamn, T. and Rylander, R. EXPERIMENTAL REQUIREMENTS FOR THE TOXICOLOOIC EVALUATION OF TOBACCO SMOKE IN THE RESPIRATORY SYSTEM. American Review of Respiratory DiseasiTOITTre 237737 Vis 1969. A 12119 A 12135 (continued) Castagnoli, N., Jr., Melikian, A. P., and AND ITS DEPENDENCE ON THE HOST.) Roenati, V. Oazzetta Sanitaria 403):106-8, 1969, THE SYNTHESIS OF PYRROLIDINE-SUBSTITUTED TrITTIF-(rEF77---- NICOTINE ANALOOS., Journal of Pharmaceu- tical Sciences 58t7):SSO-3,-7u1 1969. Experimental work on carcinogenesis from chemical agents shows that when the predisposing conditions are induced by A 12121 a carcinogen, a noncarcinogenic agent can Bennett, A. and Fleshier, B. contribute to the growth of the tumor. A HYOSCINE-RESISTANT EXCITATORY NERVE Other experimental data show that the PATHWAY IN GUINEA -PIG COLON. Journal condition of the host animal, on which of Ety11222fix 203(1):62P-3P, Jul 2969% chemical carcinogenesis depends, may be modified by even a mild action of other carcinogens. When the host animal A 12122 acquires this new condition, noncaroino- Van Duuren, B. L., Sivak, A., Ooldachmidt, genic chemicals or chemicals that are B. M., Katz, C., end Melchionne, S. only mildly carcinogenic in the majority CARCINOGENICITY OF HALO-ETHERS. Journal of the animals may become carcinogenic. of the National Cancer Institute 43t27: As the carcinogenic action of chemical rek7s7rwr9u.------compounds depends on the condition of the host organism, studies on the host are as important as those on chemical agents as A 12123 regards cancer prevention. (Author Chan, P. C., Sanders, F. K., and Wynder, Abstract) E. L. EFFECT OF 3,4-BENZO(a)PV,FNE ON MOUSE LUNG FRIMORDIA IN VITRO. -Nature 223(5208)1 A 12138 847-8, Aug-1737-M. Stern, E. and Mickey, M. R. EFFECTS OF A CYCLIC STEROID CONTRACEPTIVE REGIMEN ON MAMMARY GLAND TUMOR INDUCTION A 12124 IN RATS. British Journal of Cancer 23(2)1 Wyrder, E. L. and Hoffmann, D. 391-400, Jun 1969. A STUDY OF TOBACCO CARCINOOENESIS. X. Tumor Promoting Activity. Cancer 24(2): 289-301, Aug 1969. A 12155 Stefanovich, V., Gore, I., Kajiyama, G., and Iwanaga, Y. A 12131 THE EFFECT OF NICOTINE ON DIETARY Borisyuk, Yu. P. ATHEROOENESIS IN RABBITS.E*perimental and Molecular Pathology 11(1) :71-61, PAX AMMO( Y KP61C, PNIMtbUVHTPATPAKKEAVHui Aug 1989. MAEnt.EMnPOOOKTOZKYPIDSAJA. RAK LEOKIKH U KRYS, VYLVANNYY INTRATRAKHEALINYM VVEDENIYEM PRODOKTOV A 1P156 KURENIYA. (CANCER OF THE LUNG IN Mayan", S. and Imaizumi, T. RATS INDUCED BY INTRATRACHEAL IN- CARCINOGENIC ACTION OF N-HITROSODIGUTIS- TUBATION OF TOBACCO SMOKE PRODUCTS.) AMINE IN MICE. Gann 60(3):353, Jun 1969. VoproayOnkolo 1§(6):49-53, Jun rngTRuse anA a.) A 12160 During 8-10 months rats were intubated Dipaolo, T. A., Nelson, R. L., and intratracheally with pure and denicotin- Donovan, P. J. ized tobacco resin as well as neutral SARCOMA - PRODUCING CELL LINES DERIVED resin consisting of polycyclic hydro- FROM CLONES TRANSFORMED IN VIM BY carbons. As a result, 12 months follow- BENE0(a)PYRENE. Science -r65T389-6): ing the cessation of intubation (neutral 917-8, -Aug 29, 19m---- resin) it. 2 animals squamous cell keratoid cancer of the lung developed.In two rate pretumor changes were observed. (Author A 12166 Abstract) Ito, N., Riau, Y., Tamil, A., and Yoshida, K. EFFECT OF UNILATERAL NSPHRECTOMY ON THE A 12135 DEVELOPMENT OF KIDNEY TUMOR IN RATS Yoshida, T. TREATED WITH N-NITROSODIMBTHYLAMINB. CARCINOGENESI CHIMICA B SUA DIPENDEN2A Gann 60(3:319-27, Jun 1969. DALL'OSPITE. (CHEMICAL CARCINOOENESIS

67 71 A 12167 A 12184 (continued) Clinical Pharmacology and Therapeutics. NOT CAUSE LUNG CANCER?Criticism of an APPLICATION OF METABOLIC DATA TO THE Article by J. van Juiaingha, Entitled EVALUATION OF DRUGS. A Report Pre- "Cigarettes Which Do Not Cause Lung pared by the Committee on Problems of Cancer.") Chemisch Weekblad 63(29): Drug Safety of the Drug Research Board, 329-33, Jul 21, 19677DUTZE(Abs.) National Academy of Sciences-National Reaearch council. Clinical Pharmacelo Polemics are presented against an and Therapeutics 10 4 - ep c article by J. van Julaingha (this rgrO. journal, IA, 253, 1967).Cigarette smoke, even in nicotine-free and low- tar cigarettea, contains many carcinogens. A 12171 The fact that smoke was collected from Henke, C. T., Chaudhry, A. P., Neiders, certain allegedly harmless cigarettes Y. E. and was not seen to induce tumors proves RELIABILITY OF EXPOLIATIVE CYTOLOGY IN nothing since the mechanism of inducing INDUCED CARCINOMA IN HAMSTER'S POUCH. tumora differs greatly from the manner Acta caologa 13(2)894-8, Feb 1969. a spontaneous tumor in the lungs occurs. Voluntary inhaling of cigarette smoke cannot be compared to forced inhaling of A 12178 such smoke by experimental animals. In Friedrich-Freksa, H. and Hoffmann, M. addition, noncarcinogens contained in the IMMUNOLOGICAL DEFENCE AGAINST smoke of specially treated cigarettes can FRLNEOPLASTIC STAGES OF DIETNYINITROS- irritate and cause in the bronchi' an AMINE INDUCED CARCINOMAS IN RAT LIVER. accumulation of influenza bacteria which NaWre 223(5211)81162-3, Sep 13, 1969. can facilitate the occurrence of lung cancer.The anticarcinogens stipulated by van Julainghe are considered specula- A 12180 tive in their nature and there is cur- Burton, H. R., Benner, J. F., and Burdick, rently no reliable proof that they in D. fact do exist. THERMAL DECOMPOSITION OF TOBACCO III. A CLASSIFICATION OF CHEMICALLY-TREATED TOBACCO USING THERMOGRAVIMETRIC ANALYSIS. A 12) 93 Tobacco 169(13):45-8,'Sep 26, 1969. Shamray, Ye. F., Dzyubko, N. Ya., and Stetsenko, I. P. eMbierebE nVOCKOMM-AXA4AQUkfttE 1,1 A 12181 °KAMM:4106E 0CCOOPS4J1OPOMI-112E MaCKV)V1PHO Miele, B. nEttmDm uwaHaocu THE NICOTINIC STIMULATION OF THE CAT VLIYANIYEGALASKORTNACITSMN9Prtil. ADRENAL MEDULLA. Archivea Internationales OKISLITELINOYE FOSFORILOROVANUE de PharmacodynamieFrartherapie Z7912)8 MITOKHONDRIY PEOHENI ZNIVOINYKH C 5(3-51, Jun 1969. INDUTSIRCVANNYMI OPUKHOLYAMI. (THE EFFECT OF OALASCORBIC ACID ON RESPIRA- TION AND OXIDATION-PHOSPHORYLATION OF THE A 12182 HEPATIC MITOCHONDRIA IN ANIMALS WITH MS Tokar, R. L. and Clobber, O. L. INDUCED TUMORS.)yoprosy Onkcaoga ANALYSIS OF NICOTINE-INDUCED VASCULAR 15(7)865-7, Jul 1989-, Russian IK6 7;) REFLEXES IN THE DOG. Archives Inter- nationales de Pharmaco37605errei The studies were carried out on 62 Therapie 175iTt/s408-18, Jun i9 T.`- nonpedigreed rata with tumors induced by single infections of 9,10-dimethy1-1,2- benzenthrapene.The mitochondria' respi- A 12183 ration was determined manometrically. Hamill, W. and O'Neill, R. P. There was observed some intensification of CARBON MONOXIDE INTOXICATION IN CIGAR respiration of the hepatic mitochondria in SMOKERS. Irish Journal of Medical animals with tumors in comparison with Science 2(6727377771711t97----- normal animals in considerably reduced phoaphorylation ant coefficient P/O, that evidences the dissociation of there pro- A 12184 ceasea and assumption of a lees effective Emmerlot, P. non-phosphorylating means of respiration. SIOARETTEN DIE OEEN LONGKANKER Injection of galascorbic acid has no VEROCOZAKEN?Kritiek op een Artikel effect on the intensity of mitochondria' van J. van Julsingha, Oetiteld respiration but considerably increases "Sigarstten die Omen Longkanker phosphorylation and coefficient P/O thus Veroorzaken." (CIOARETTES WHICH DO reducing dissociation and contributing to more adequate energetic respiration. (Author Abstract) A 12196 A 12202 (continued) Wetep, I. have more carcinogen properties than NOWOTWORY A ZJAWISKA ODPORNOSCIOWE. cigar and old-fashioned pipe tobaccos (TUMORS AND DEFENSE PHENOMENA.)Poste which have an alkaline smoke and general- Hi ioni Med c Dcswiadczalnej ly are not inhaled.Ha goes beyond - ,1 , o ish (Abe.) Beffinger, however, in claiming that not only the curing method but the size of Pefense against tumors is discussed by tobacco particles has an influence in the means of a literature review with 293 carcinogenic properties of the tobacco references. The notion that tumors cause (and smoke). the formation of antigens and that by preparing antigens of sufficient purity tumors could be cured has found more A 12227 adherents in modern medicine. These Shuba, E. P. ideas are based on such factors as the MUNIANite 9,10-4WEW-1,2-6EWOMPAICEMAmA high specificity of tumors created by CQEEp3X/S3VE KANEJA,HATIVIAM WU% X live virus. Thus, Roust virus will create POCAEW0011W4-14. a sarcoma, whereas Shopete virus will VLIYANIYE 9,10-DIMETIL-1,2-BENZANTRATSENA create a papilloma of the skin. Antigens NA SODERZHANIYE KALIYA, NATRIYA I KHLORA will interfere with oncogeneais provoked V MYSHECHNOY TKANI. (EFFECT OF 9,10- by such virue by acting on the DNA. DIMETHYL-1,2-BENZANTHRACENE ON POTASSIUM, Experimental oncology soon taught that SODIUM AND CHLORINE CONTENT ON MUSCLE certain lipoprotein fractions would lead TISSUE.) Ukrainsikyi Biokhimichnyi to immunological enhancement and also pro- Zhurnal 4113):251,2, 1969, Russan (Abs.) duce concomitant immunity. Once tolerance is developed (i.e. a way to make the Potassium, Sodium and chlorine content lymphocytes accept the antigens) immuno- in muscular tissue were investigated in therapy of tumors in humane could be different periods after the beginning initiated, a defense mechanism induced in of 9,10-dimethy1-1,2-benzanthracene effect the human organism and the regression of on it. It is found that on the 10th day certain tumors brought about. Preparation after Its introduction the ConCentre4nn of this type sera ie not new since in 1901 of potassium decreases by approximate Dar had already developed a serum which 13.8 percent. During the following days effected pascive immunization.Sub- it does not change essentially.A fur- sequently, sera were prepared which are ther decrease of its content is observed allogenic or heterologic gamma globulins. only in 120 days when the tumor undergoes This treatment has set-backs since, for complete development.By this time it instance, the endothelium might becom, comprises 23.6 percent on the average. affected. In contrast to potassium the concentration of sodium in muscular tissue increases by 46.3 percent 10 days after A 12202 introducing the cancerogen. It increases van Proosdij, C. by 78.1 percent in comparison with the CARCINOOEWEN IN TABAKSROOK. (CARCINOGENS norm in a developed rabdomyoblastoma. IN TOBACCO SMOKE.) Nederlands TiJdschrift Chlorine content ih muscular tissue under voor. Geneeskunde 1121221:1046-6, Jun 1, the influence of 9,10-dimethy1-1,2- frrg, Dutch (Abe.) benzanthracene also increases by 48.9 percent by Cle 10th day of its effect. The author has commented on the re- During the following days a further mar!'s of W. Krijgeman-de Bouve who had gradual increase in chlorine content is attributed the harmfulness of cigarettes observed, in the developed rebdomyo- to the replacement of natural fermenta- blaetoma it reaches 148.9 percent. Thus, tion curing of tobacco by more rapid the change in potassium, sodium and artificial curing techniques. van chlorine content of muscular tissue Prooedij considere this an oversimplifica- occurs at the beginning of the tion of the problem. He traces the cancertgenic effect on a muscle. development of the cigarette industry in (Author Abstract). the United States and Europe and tells how the United Staten captured the world cigarette market by better cultivation A 12232 techniques, more rapid curing techniques, Magee, P. N. and Swann, P. F. introduction of new varieties of tobacco, NITROSO COM S. British Medical namely, Burley and Bright, and the intro- Bulletin 25(3 ) :240-47-57171-9m7---- duction of a completely new product, 'sweetened Burley' tobacco by the Reynolds Tobacco Company in 1913. The rapid drying technique however, resulted in an acid smoke and was considered to A 12233 A 12270 (continued) Shetty, A. S. end Miller, G. W. Oto-Laryngologica 68(1- 2):118 -26, Jul-Aug PURIFICATION AND GENERAL PROPERTIES OF IT69. DELTA-AMINOLAEVULATE DEHYDRATASE FROM grUTIANA TABACUM L.Biochemical 76717a1-114(2):3S1-7, A 12287 Ito, N., Hiasa, Y., Tamai, A., Okajima, E., and Kitamura, H. A 12242 HISTOGENESIS OF URINARY BLADDER TUMORS Vincent, R. G. INDUCED BY N -BUTYL -N-(4-EYDROXYBUTYL)- SMOKING. Reducing the Dangers. NITROSAMINE IN RATS. Gann 60(4):401 - Minnesota Medicine 52(8):1314-8, 10, Aug 1969. rfrrtirr

A 12297 A 12256 Stutman, 0., Yunis, E. J., and Good, R. A. Pollard, M., Kajima, M., and Zacharia, T. P. CARCINOGEN-INDUCED TUMORS OF THE ThYMUS. ROUS SARCOMA VIRUS IN GERMFREE RATS. III. RESTORATION OF NEONATALLY Advances in Experimental Medicine and THYMECTOMIZED MICE WITH THYMOMA3 IN ET61707.371-40- 2, 196-9. CELL - IMPERMEABLE CHAMBERS. Journal of the National Cancer Institute 43(2): T3T -507, Aug 7777- A 12257 Grant, G. A. and Roe, F. J. C. COMPARISON BETWEEN THE EFFECTS OF A A 12299 SINGLE DOSE OF A CHEMICAL CARCINOOEN Baron, J. and Tephly, T. R. ON GNOTOBIOTIC AND CONVENTIONAL MICE. THE ROLE OF HEME SYNTHESIS DURING Advances inexperimentalMedicine and THE INDUCTION OF HEPATIC MICROSOMAL BIZI7Er37r43- , 1969. CYTOCHROME P-450 AND DRUG METABOLISM PRODUCED BY BENZPYRENE. Biochemical and Biophysical Research r-EmRIFTETEions A 12258 Str4):526-;32, Aug 15, 1969. Kajima, M. VIRAL STATUS OF GERMFREE RODENTS; PRESENT AND FUTURE. Advances inExperimental A 12300 Medicine and Brargr371-0- 4, 1969. Juchau, M. R. and Yaffe, S. J. BIOTRANSFORMATIONS OF DRUG SUBSTRATES IN PLACENTAL HOMOGENATES. IN: Trabucchi, A 12259 E. (Chairman) The Foeto-Placental Unit Kajima, M. International Symposium, Milan, September 7,12-DIMETHYIDENZ(a)ANTERACENE-INDUCED 4-6, 1968, Excerpta Medics. International MALIGNANT LYMPHOMA-IN GERMFREE MICE. Congress Series, No. 183, 1968, Advances in Experimental Medicine and pp. 260-70. 717175-3153-61, 1969.

A 12306 A 12266 Parks, A. 0., Fishlock, D. J., Cameron, Olson, P. R. and Wattenberg, L. W. J.D.H., and May, H. INHIBITION BY 5-FLUOROURACIL OF THE PRELIMINARY INVESTIGATION OF THE EARLY STAGES OF CHEMICAL CARCINOOENESIS PHARMACOLOGY OF THE HUMAN INTERNAL IN MOUSE SKIN. (54C64). Proceedings of ANAL SPHINCTER. Out 10(8):674-7, the Society for Experimental Blob airer Aug 1969. MFFicine 131 :1135 -7, Sap 1

A 22306 A 12267 Wechsler, W., Kleihues, P., Matsumoto, Kovacs, K. and Somogyi, A. S., Zulch, K. J., Ivankovic, S., PREVENTION BY SPIRONOLACTONE OF 7,12- Preustmann, R., and Druckrey, H. DIKETHYLBENZ(a)ANTHRACENE-INDUCED ADRENAL PATHOLOOY OF EXPERIMENTAL NEUROOENIC NECROSIS. (31103). proceedings of the TUMORS CHEMICALLY INDUCED DURING Societ for Experimental Biolo PRENATAL AND POSTNATAL LIFE.Annals c ne-r3114P1350-2, Sep of the New York Academy of ScieTRIDT- ITOMIN5-0F7 A 12270 Tibbling, L. THE INFLUENCE OF TOBACCO SMOKii0, NICOTINE, CO AND CO2 ON VESTIBULAR NYSTAGMUS.Acta

70 74 A 12310 A 12331 Wall, M. E., Abernethy, G. S., Carroll, Nilsson, S. and Fangs, R. F. I., and Taylor, D. J. ADRENERGIC AND CFILINERGIC VAGAL THE EFFECTS OF SOME STEROIDAL EFFSCTS ON THE STOMACH OF A TELEOST ALKYLATING AGENTS ON EXPERIMENTAL (GADUS MORHUA). Comparative Bio- ANIMAL MAMMARY TUMOR AND LEUKEMIA chemistry physiology 30(47T- SYSTEMS. Journal of Medicinal 091-4, WIT; 1969. Chemistry 1751:1173=g, Sep 19E9. A 12335 A 12313 Iida, T., Gassner, E., and Sayegh, F. S. Welsch, C. W., Clemens; J. A., and TETRACYCLINE IN TUMORS. Oral Meites, J. Surgery, Oral Medicine an375Fal EFFECTS OF HYPOTHALAMIC AND AMYGDALOID Pathology-31',77p-ITS-9. LESIONS ON DEVELOPMENT AND GROWTH OF CARCINOGEN-INDUCED MAMMARY TUMORS IN THE FEMALE RAT. Cancer Research 29(8): A 12337 1541-9, Aug 1969. Burki, H. R. and Okita, G. T. IN VIVO OXIDATION OF GLUCOSE-1-14C X70-0111tosE-6-14C IN MICE WITH A 12314 7,12-DIM33THYLBENZ(a)ANTHRACENE- Hatfield, G. M. INDUCED TUMORS. Jgurnal of the CARCINOGENS IN TOBACCO SMOKE. National Cancer IHTETEUge73177: Journal of the American Pharmaceutical 843-51, snr1179. nikTITtion-RE9rjrag37 466-8, Sep 1969.

A 12338 A 12326 Kurita, Y., Sugiyama, T., and Warwick, K. M. and Eysenck, H. J. Nishizuka, Y. EXPERIMENTAL STUDIES OF THE BEHAVIOURAL CHROMOSOME ABERRATIONS INDUCED IN EFFECTS OF NICOTINE: II INTERACTION OF RAT BONE MARROW CELLS BY 7,12- SEX AND SMOKING HABITS. Pharmako- DIMETHYLBENZWANTHRACENE. Journal paychiatrie Neuro-Pa ychopharmakologie of the National Cancer InstaalF- 2(3j:217-22, Aug 196g. 0137T635-s, e411069.

A 12327 A 12340 Deane, R. F. Burdick, D., Benner, J. F., and TRANSMURAL ELECTRICAL STIMULATION OF Burton, H. R. THE URETER,British Journal of THERMAL DECOMPOSITION OF TOBACCO IV. Urology 41(4):417-2u,AWIT6T7 APPARENT CORRELATIONS BETWEEN THERMOGRAVIMETRIC DATA AND CERTAIN CONSTITUENTS IN SMOKE FROM CHEMICALLY- A 12328 TREATED TOBACCOS.Tobacco 169(14)1 Todd, J. K. and Mack, A. . 21-4, Oct 3, 1969. A STUDY OF HUMAN BLADDER DETRUSOR MUSCLE. British Journal of Urology 41(4):448:51,717gITS77 A 12342 Thompson, J. N. and Scott, M. L. ROLE OP SEIENIUM IN THE NUMITION OF A 12329 THE CHICK. Joulnal of Nutrition Bywater, R. J. 97(3):335-427-W7T98'9. SOME RESPONSES OF BOVINE INTESTINAL MUSCULATURE TO HUMORAL AGENTS IN VITRO AND IN VIVO. Archives Internagroarii A 12355 de PERrEandynKEI-Tr-de Therapie Codegone, M. L., Provana, A., Ohittino, P., 119T77:459--68, Jun 1T677 and Palestro, 0. STUDIO SPERIMENTALE SULL'AZIONE DI ALCUNI CANCEROGENI SUL FEGATO DELLA TROTA. A 12350 (EXPERIMENTAL STUDY ON THE ACTION OF Fox, W. B. SEVERAL CARCINOGENS ON THE LIVER OF ARE YQU USING TOBACCO?Hahnemannien TROUT.) Cancro 21(5):469-76, 1968, 104(3 }t12 -5, Sep 1569. Italian (rsir7r-

The authors tested the effect of three known carcinogens (o-amino-azotoluene, An; dimethylnitrosamine, DMN: crystalline aflatoxin 81, AFT) on the liver of rain- A 12555 (continued) A 12360 bow -- and brown -- trout kept in water at Schnitger, F. and Uehleke, H. 8.9°C. Such carcinogens were mixed with DER EINFLUSS VON DIMETHYINITROSAMIN, fresh beef liver and continuously fed for TETRACHIORKOHLENSIOFF, BUTTERGELB UND 18-22 months to experimental trout. The CYCLOPHOSPHAMID AUF DEN AMINOSAURENEINBAU level in the diet of AAT and DMN as 800 IN FRAKTIONEN VON LEBERHOMOOENATEN MACH ppm, of AFT 8 ppb. The incidence of METABOLISCRER AKTIVIERUNG IN VITRO. hepatomae (microscopically detectable) Moglichkeiten Der ErfassungHepM- was very low (2 percent) and limited to toxischer Wirkungen. (THE INFLUENCE OF the rainbow trout fed AAT and AFT. The DIMETHY1NITROSAMINE, CARBON TETRACHLORIDE, authors consider that this finding may be BUTTER YELLOW AND CYCLOPHOSPHAMIDE ON connected with the supporting diet in AMINO ACID INCORPORATED INTO FRACTIONS OF which the carcinogens were fed; they LIVER HOMOGENATE AFTER IN VITRO METABOLIC discuss the other modalities of adminis- ACTIVATION. Evaluation76f-Ri7totoxic tration of such compounds used by Aotion.)Archly fur Toxikologie; Fuehner- previous authors in trout and in other Wielands Sec=sun& von Ver iftu afiFITE laboratory animal.:. (Author Abstract) 25t2):169-82, 19697Terman ADS. 4-N,N-dimethylaminoazobenzene (butter A 12356 yellow), 4-N,N-dimethylaminoazobenzene- Neurath, O. N4-oxide, dimethylnitrosamine, carbon STICKSTOFFVERBINDUNGEN DES TABAKRAUCHES. tetrachloride and cyclophosphamide (2 (NITROGEN COMPOUNDS IN SMOKE.) microMol/M1) did not influence the in- Arzneimittel-Forschung 19(7J:1093- corporation of 14C-leucine into proteins 106r, Jul 1967, German (Abs. of liver homogenate, 9,000 X g-supernatant and isolated miorosomes from rate Knowledge of tobacco smoke composition pretreated with phenobarbital. Rapid grows rapidly by application of modern metabolism of the foreign aubstances in analytical methods.Hitherto, lei nitro- the incubation mixtures was accomplished gen compounds are known comparable to 50 by addition of a NADPH2-regenerating sys- in 1959, cooprising 24 aliphatic amines, tem. There was also no inhibition of 19 aromatic amines, 7 nonaromatic N- leucine incorporation 'Ender these condi- heterocyclic comfounds, 26 pyridine tions. Prior incubation of microsomes bases, 6 other six-membered N-heterocyclic with NADPH2 as well as with the toxic compounds, 2 pyrroles, 15 other five- agents changed neither the leucine in- membered N-heterocyclic compounds, 12 corporation nor the poly-(U) directed pyrazines, 16 tobacco alkaloids and com- incorporation of 140-phenylalanine.The pounds with two nitrogen rings, 15 amino activity of mixed-function oxidases was acids, 16 nitriles, 6 nitroalkanes, some ascertained by measuring dealkylation of derivatives of nitrous acid, inorganic N-methylaniline as a standard substrate cyano compounds, nitrogen oxides, ammonia, (1 microMol/m1).Dealkylation at and elemental nitrogen.The balance of the end of 10 minutes were: 16 percent all the nitrogen compounds in tobacco in the homogenates, 8.8 percent in 9,000 smoke condensate gives a hint at the X g-supernatant, 3.6 percent in isolated occurrence of unknown neutral N-compounds. microaomes and 6 percent in the complete (Author Abstract) amino acid incorporating system with microsomes. The subcellular systema investigated are therefore not suitable A 12357 as models for the study of the toxin Palestro, G. and Codegone, M. L. action of foreign substances on the pro- EFFETTI DELLA SOMMINISTRAZIONE DI tein synthesis in intact cells and organs. DIMETILNITROSOAMINA FER VIA ORALE IN (Author Abstract) RATTI ADuLTI. (EFFECTS OF THE ORAL ADMINISTRATION OF DIMETHYLNITROSAMINE IN ADULT RATS.) Patholo ica 60(889- A 12165 890)1395-9, Sep-Orr; , talisn (Abs.) Hayashi, I., Yoshida, K., Hiasa, Y., Taai, A., and Ito, N. The authors have added various concen- JIKKENTEKI JINSHUY0 NO CHIRYO NI KANSURU trations of DMN to the drinking water of KENKYU. II. MITOMYCIN C, 5-FLUCROURACIL adult rats.The highest doses caused OYOB/ ENDOXAN NO JIKKENTEKI :INSHUYO E NO acute toxicity with early death and led EIKYO NI TSUITE (STUDIES ON THE TREATMENT to tumors which were mainly located in OF EXPERIMENTAL RENAL TUMORS.II. EFFECT the kidney. Lower doles, even if admin- OF MITONYCIN C, 5-FIVOROURACIL AND istered for a long period of time, had ENDOXAN ON EXPERIMENTAL RENAL TUMORS.) very little acute toxicity. The Hinyokika an.15(b)1547-52, Aug 1969, carcinogenic effect was shown exclusively Japdnese (XI17.1 in the liver. Thee! data agree with the results obtained by other authors. (Author Abstract) A 12363 (continued) A 12580 Kronman, B. S., Rapp, H. J., and Tibor, B. The effects of various cancer chemo- TUMOR-SPECIFIC ANTIGENS: DETECTION BY therapeutic drugs, such as mitomycin C LOCAL TRANSFER OF DELAYED SKIN HYPER- (MMC), 5-fluorouracil (5-FU) and endoxan SENSITIVITY. Journal of the National on rat kidney tumor induced by feeding Cancer InstituriliT(T)769=n, Oct 1969. dimethylnitrosamine (DMN) were studied. Endoxan injected intraperitoneally showed relative inhibitory effects on the DMN- A 12381 induced kidney tenors. Histologically, Burns, J. J. necrotic and edewatous changes were INTERACTION OF ENVIRONMENTAL AGENTS found in the kidney tumor tissue in AND DRUGS. Environmental Research endoxan-treated rats. No inhibitory 2(5-6):352-9, Oct 1969. effects were observed in the groups treated with other drugs.(Author Abstract) A 12382 Talukder, G. and Sharma, A. K. CYTOLOGICAL STUDY OF INDUCED TUMOURS A 12568 IN RAT. Indian Journal of Cancer 6(2): Federal Trade Commission. 93-8, JunT9697 REPORT OF THE TAR AND NICOTINE CONTENT OF THE SMOKE OF 118 VARIETIES OF CIGARETTES. Federal Trade Commission, A 12384 Washington, D. C., Jul 19, 1969, 14 pp. Rose, E. F. CARBON MONOXIDE INTOXICATION AND POISONING. Journal of the Iowa A 12372 Medical Society 59057:9.07-177 Nebert, D. W. and Gelboin, H. V. Oct 1969. THE IN VIVO AND IN VITRO INDUCTION OF ARYL-RVORMARECN-TIVVITUMASE IN MAMMALIAN CELLS OF DIFFERENT SPECIES, A 12388 TISSUES, STRAINS, AND DEVELOPMENTAL Stutman, 0., Yunis, E. J., and Good, R. A. AND HORMONAL STATES. Archives of CARCINOOEN-INDUCED TUMORS OF THE THYMUS. Biochemistry and Bioph7077-1747)176- IV. Humoral Influences of Normal Thymus 89, Oct 1969. and Functional Thymomas and Influence of Postthymectomy Period on Restoration. Journal of Experimental Medicine 130(4): L 12376 8 Ur197 OTt I-, 1969. Just, J., Maziarke, S., and Wyszynska, H. CARCINOGENIC HYDROCARBONS IN THE ATMOSPHERE OF CERTAIN POLISH CITIES. A 12388 Polish Medical Soience and Histor Zimmerman, H. X. euIletiirrY(Trar1737arl . BRAIN TUMORS: THEIR INCIDENCE AND CLASSIFICATION IN MAN AND THEIR EXPERIMENTAL PRODUCTION. Annals A 12378 of the New York Academy of-Sc TEcea Zbar, B., Wepeic, H. T., Rapp, H. J., I39r271337-577Vui-22, 1969. Whang-Peng, J., and Borsos, T. TRANSPLANTABLE HEPATOMAS INDUCED IN STRAIN-2 GUINEA PIGS BY DIETHYLNITROS- A 12392 AMINE: CHARACTERIZATION BY HISTOLOGY, Gauthier, P. and Nadeau, R. A. OROWTH, AND CHROMOSOMES. Journal of EFFECTS OF NICOTINE INJECTED INTO THE the National Cancer inatitalT3T47T ATRIOVENTRICULAF NODS ARTERY OF THE DOG. Oct1969.7 Journal of Pharmacology and EXPetimental TEFFIrgurres 169[2):29-8-07, Oct 1969.

A 12379 Zbar, B., Wepsic, H. T., Rapp, H. J., A 12396 Borsos, T., Kronman, B. S., and Cuparencu, B., Tics', I., Ssfta, L., Churchill, W. H., Jr. Rosenberg, A., Mocan, R., rind Brief, Oh. ANTIGENIC SPECIFICITY OF HEPATOMAS INFLUENCE OF SOME PSYCHOTROPIC DRUGS ON INDUCED IN STRAIN-2 GUINEA PIGS BY THE DEVELOPMENT OF EXPERIMENTAL ATHERO- DIETHYINITROSAMINE.Journal of the SCLEROSIS. CoretVasa 11(2):112-21, National Cancer InstiTZTIMIr7110I- 1969. 41, OCt 11107

73 97 A 12599 A 12421 Lopez, P. L., Preston, R. L., and Lalonde, E. R. Pfander, W. H. ABSORPTION THROUGH ORAL MUCOUS MEMBRANES. WHOLE-BODY RETENTION, TISSUE DISTRIBU- Journal of Dental Research 48(5, Part 1, TION AND EXCRETION OF SELENIUM-75 upiSsr$071-,-rip-Octl9r9. AFTER ORAL AND INTRAVENOUS ADMINIS- TRATION IN LAMBS FED VARYING SELENIUM INTAKES. Journal of Nutrition 97(1): A 12424 123-32, Janes Bartle, K. D., Jones, D. W., and Matthews, R. S. NMR CHEMICAL SHIFTS IN CARCINOGENIC A 12400 POLYNUCLEAR HYDROCARBONS. Journal Pyrah, L. N. of Medicinal Chemistry 12(6) 17X275, JOHN HUNTER AND AFTER: RENAL CALCULI ms-v-TgaT7 AND CANCER OF THE BLADDER. Annals of the Royal College of SurgeonTIET-- ETTliTIri;II/TI-42, Jul 1969. A 12426 Dale, M. M. IMMUNE STATUS OF GUINEA PIGS ON A 12401 LONO-TERM CARCINOGEN TREATMENT. Lee, M., Dong, A., and Yam', J. British Emigre Cancer Campaign METABOLISM OF 75SE-SELENITE BY HUMAN 1711-1417e1WW-KnEZET-report 461411, WHOLE BLOOD IN VITRO.Canadian rT6-6. Journal of BirenZ7istry 47(61:791 7, Kurrns. A 12427 Ingram, D. J. E. A 12405 EPR STUDIES OF IRRADIATION DAMAGE IN O'Brien, R. L., Stanton, R., and POLYCYCLIC AROMATIC HYDROCARBONS. Craig, R. L. British Em ire Cancer Campaign for CHROMATIN BLNDING OF BENZO(a)PYRENE Aliffr,c11, nnual-WOrt 46143147-1968. AND 20-METHY1CHOLANTHRENE. -Biochimica et Biophysica Acta 166(2)141r:177ml- A 12436 Ealldin, B. FOROIFTNINOSTILLBUD HOS BARN: A 12407 TOBAK OCH LAKEMEDEL VANLIOASTE Levij, I. S., Rwomushana, J. W., and ORSAK. (NARROW ESCAPES IN POISON- Polliack, A. ING OF CHILDREN: TOBACCO AND ENHANCEPUENT OF CHEMICAL CARCINOGENESIS MEDICINES THE MOST COMMON CAUSE.) IN THE HAMSTER CHEEK POUCH BY PRICK Lakartidningen 66(21)12230-4, May TOPICAL APPLICATION OF VITAMIN A el, 1969, Swedish (Abs.) PALMITATE. Journal of Investigatie Dermatolrel6313):228731, sep 1969. A total of 864 cases of poisoning or near-poisoning were treated at a children's clinic in Aalmo, Sweden A 12411 from 1965 to 1967.The accidents Nedergaard, O. A. and Bevan, J. A. occurred most frequently in 9-month EFFECTS OF NICOTINE, DIMETHYL- to 3-year olds. Tobacco (57 percent) PHENYLPIPERAZINIUM AND CHOLINEROIC and drugs (22 percent) constituted BLOCKING AGENTS AT ADRENEROIC NERVE the chief cauees of poisoning. ENDINGS OF THE RABBIT PULMONARY Treatment was good in 90 percent ARTERY. Journal of PharmacoloU of the cases with only 14 percent and RxperNEMT Merapeutical68(1): requiring hospitalization. Ten per- r27-35, Jul- 1969. cent of cases were repeaters. The one fatality was a 20-month-old toy who had consumed 10 migraine tablets. A 12418 Research to produce safer packaging Barraee, B. C. Blackburn, J. W., was urged. Brimblecombe, R. W., and Rich, P. MODIFICATION OF NICOTINE TOXICITY BY PRETREATMOT WITH DIFFERENT DRUOS. A 12437 Biochemical Pharmacology 18(9): Kassau, E. FrW:32774176 77- UBER DIE MIKROSUBLIMATION EINIGER CARCINOGENER STOFFE UND EINIOER HOHERER C4RBOCYCLISCHER KOHLENWASSER- STOFFE. (ON THE MICROSUBLIMATION OF A 12437 (continued) A 12439 (continued) SEVERAL CARCINOGENIC SUBSTANCES AND duction of finger skin temperature HIGHER CARBOCYCLIC HYDROCARBONS.) were more marked in the subjects Deutsche Apotheker-b4twal09(34): whose inhalation was deeper and the 1290-3, Aug 21, 1969,-UTRilan (Abs.) return of these parameters after smoking to their initial level were The behavior of several carcinogenic delayed according to the depth of the substances and several higher aromatic inhalation. Therefore the vascular hydrocarbons was described. The com- responses in cigarette smoking may pounds included pyrene and 1,2-and 3-4, be dependent on the depth of the benzopyrene, 9,10-dimethy1-1,2-benz- smoker's inhalation. (Author anthracene, 1,213,4-and 1,2:5-6- Abstract.) dibenzanthracene, 20-methylcholanthrene, and two azobenzene derivatives. Litera- ture sources for the reactions of the A 12443 substance.: were cited. Department of National Health and Welfare, Canada. SECOND REPORT ON CANADIAN CIGARETTE A 12438 TAR-NICOTINE CONTENT RELEASED. Rosenberg, A. Department of National Health and KONTROLLERET TOBAKAPVAENNING. (CON- Welfare, Ottawa, Canada, May 27, TROLLED TOBACCO DETOXICAT1ON.) 1969, pp. 1-3. ygeekrift. for Laeteri 130(47):2014, NO-Ti-21-,--Y9R7 Dan p (Abs.) A 12446 Six cases, all long-time smokers, Campese, V. M. and Mitolo-Chieppa, D. who discontinued smoking in order to INDAGINE SUL MECCANISMO VASORILASSANTE reduce the carbon monoxide of the DELLA NICOTINA CONDOTTA ATrRAVERSO UNA blood, were reported briefly.They ANALISI DEI GRUPPI FUNZIONALI DELLA ranged in age from a 35-year-old SOSTANZA. (INVESTIGATION OF THE male to a 65-year-old female. In VASORELAXANT MECHANISM OF NICOTINE one case, the carbon monoxide content CARRIED OUT THROUGH AN ANALYSIS OF dropped from 9 percent to 0 percent. ITS FUNCTIONAL GROUPS.) Bollettino in 8 days. In another representa- della Societe Italiana di Biologie tive case, the carbon monoxide con- SIDiFiMMg1i44(23):2112747-ron-1-5, tent dropped from 9 percent to 1.5 1968, Italian (Abs.) percent in 9 days, and 2 months later dropped to 0 percent. Vasorelaxant activity was tested in longitudinal strips of human umbilical cord. Pyridine showed the highest A 12439 relaxant activity but below that of Konishi, M., Yamaguchi, H., Koike, nicotine. N-methylpyrrolidine showed S., and Ishikawa, K. no relaxant action, even causing spasm; KITSUEN GA YUSISEN PLETHYSKORAM beta-pyridylcarbinal caused relaxation; NI OYOBOSU EIKYO NI TSUITE (THE ETETAinic acid caused spasm only. The EFFECT OF SMOKING ON THE FINGER- results indicated that the vaeorelaxant TIP PLETHYSMOGRAM.)Nippon activity of nicotine was not a function Eiseigakii Zasehi 24(2):328-27, of the pyrrolidine ring and that the Jun 10%9, JIMITTe (Abs.) mechanism of such activity could not be explained by a receptor of the cholinergic The skin temperature, heart rate type, but the relaxation of nicotine and finger-tip plethysmogram were operated through the pyridine ring by measured in 5 medical students during a different mechanism. and after smoking one cigarette, inhaled at three different depths, viz. deep inhalation, ordinary inhalation, A 12449 and puffing. Significant changes Stanislawski, M. were observed during smoking in the ASSOCIATION D'ANTIOENES EMBRYONNAIRES decrease of finger akin temperature, AVEC L'HEPATOKS ET D'AUTRES LESIONS the increase of heart rate, the HEPATIQUES CHEZ LE RAT. Etat Actual shortening of crest time and propa- de la Question (Suite et Fin). gation time, the reduction of volume (ASSOCIATION OF EMBRYONAL ANTIGENS change and the increase of dicrotic WITH HEPATOHA AND OTHER HEPATIC LESIONS index compared with those during sham IN RATS. Present Status of the vestion smoking. The shortening of crest (final report).) Laval Medical 40(8): time and propagation time, the in- 772.98, Oct 1969, 177iiiail7Ter7T crease of heart rate and the re-

75 79 A 12449 (continued) A 12453 Saindelle, A., Arhan, P., Oazave, J.-M., Immunoprecipitation methods have Dechy, J.-P., and Santais, M.-C. been employed to study the appearance of ANTAOONISME IN VITRO ENTRE LE FACTEUR embryonal antigens in rats in different VITAMINIQUE C=2-ETTITAIT DU DS D'ORANGE physiological states and under the in- ET CERTAINS CONSTITUANTS DE LA FUMEE DE fluence of different chemical intoxicants CIGARETTE. (IN VITRO ANTAGONISM BETWEEN and surg1cal treatments. HeAomas were THE VITAMIN CZ PACTidR EXTRACTED FROM induced by addition to the feed of the ORANGE JUICE AND CERTAIN CONSTITUENTS OF following; carcinogenae 4-dimathylamino- CIGARETTE SMOKE.)Therapie 24(4):581-8, azobenzene (DAB) 3-methy14-dimethyl- Jul-Aug 1969, French (Abs.) aminoazobenzene (3'm -DAB), N-dimethylnitrosamine (DMN , and aflotoxin B-1. Vitaminic factor C-2 extracted from Eight cares of cirrhosis of the liver orange juice accelerates reduction of have been studied, one case induced by dehydro-ascorbic acid into ascorbic acid 3'm -DAB end seven by DMN. Three embryonal by reduced glutathione. Hydrosoluble part antigens were studied; LA antigen, plea-. of cigarette smoke decreases the reaction 2-glycopzotein, and lipoprotein - esterase. rate, and antagonizes the accleration produced by the orange juice extract. Thlis property is mainly correlated with A 22450 acrolein. This in vitro antagonism be- Rohrbach, R. tween vItaminic ricT877-2 and cigarette DIE STIMULIERUNG DOPAOXYDASE-POSITIVER smoke may explain the tissue ascorbic acid NELANOCYTEN WAHREND DFR CARC]NOOENESE decrease which in vitro follows cigarette DER HAUT. (IRE STIMULATION CF smoke inhalation. -Minor Abstract) DOPAOXIDASE-POSITIVE MELANOCITES DURING SKIN CARCIINOGENESIS.) Virchcws Archly Abtellung B Zell tholo-IF-3(770T1=n, A 12454 7617177713n, uermanA s.) Candeli, A. and Morozzi, 0. IL PROBLEMA DE/1A CANCEROnNICITA DELL' - In these inveetigatione we Endeavored ARIA INQUINATAt III. TECNICA DEI to find azt whether the dopeoxidase- TRACCIANTI RADIOATIIVI PER LA poaltive melanocytee in the dorsal skin DETERMINAZIONE QUANTITATIVA DEOLI of hairless mice would react differently IDROCARBURI AROMATICI POLICICLICI. (THE to treatment with carcinogenic, cocarci- PROBLEM OF THE CARCINOGENICITY OF POLLUTED nogenic and hyperplaeiogenic, noncarcino- AIR. III. RADIOACTIVE TRACER TECHNIQUE genic subatancea. Furthermore, we explor- BY THE QUANTITATIVE In:TERMINATION OF ed the possible roll of these active, AROMATIC POLYCYCLIC HYDROCARBONS.) melanin producing cells in the develop- Giornale di I lone e Medicinepreventive ment of epithelial tumors.Carcinogenic lor0.34s7an- r-1469, Italian (Abe.) substancen, ouch as methylcholanthrene and dim ethylbenzanthracene provoked an To determine the extent to which earlier and significantly greater stint)... 3,4-benzopyrene is lost during the lation of melanocytes than weak sub- analytical procedures (column-chromatogra- stances dtxl. After administering one of phy followed by paper-chromatography) the these aubntances the number of melanocytes authors employed the tracer technique increased to about the same extent; after using 3,4-benzopyrene-H3. The H3-labeled 2-3 monthn melanotic tumors developed in benzoprvne, determinable with the liquid the Wan. The cocarcinogentc croton -oil scintillation counting technique, was caused a ranch less pronounced reaction of added to a solution of known quantity of the melanocytes, and the hyperplasiogenic, pure armstic polycyclic hydrocarbons as noncardnogenic banzanthracena was almost internal standard and quantitatively inert. For each the reaction was confined determined at the beginning and the end of to the derails only.These two substances the analysis. The experiments carried out failed to produce melanotis Vizors within glow that the recovery percentage of 34 monthn after the beginning of applica- titiated 3,4-benzopyrene corresponds to tion. Dovaoxidase-positive malanocytes the recovery percentage of the untritiated were not involved in the development of 3,4-benzopyrene and to that of the other epithelia) tumors such as papillomas, polycyclic hydrocarbons upon which experi- keratoacarithomas and carcinomas.(Author ments were made, within acceptable limits Abstract) for this type of research. The loan of such compounds is about 30 percent after the column chromatography, end about 50 percent after piper chromatcgraphy. The

eo A 12454 (continued) A 12469 analysis of the particulate matter of the Reichle, F. A., Oruenstein, M., Meranze, exhaust gas of a gasoline engine led to D. R., Rosemond, 0. P., and Shimkin, M. B. a loss of the tritiated compound which THE EFFECT OF PORTACAVAL SHUNT ON 7,12- was similar to that revealed on mixtures DIMETHYLBENZ(a)ANTHRACENE-PRODUCED of pure aromatic polycyclic hydrocarbons. MAMMARY CARCINOMA IN THE RAT. Journal (Author Abstract) of Surgical Research 9(10):559457---- UFt 1969.

A 12456 Kaempe, B. A 12470 INTERFERING COMPOUNDS AND ARTIFACTS IN Bookman, D. E. and Stutman. O. THE IDENTIFICATION OF DRUGS IN AUTOPSY FINE STRUCTURE OF A TRINSPLANTED CHEMI- MATERIAL. In Stolman, A. (Editor), CALLY INDUCED NONLYMM;ZD THYMOMA. Cancer Progress in Chemical Toxicology, Vol. 4. Research 29(9)11663-8, Sep 1969. New York and London, Academic Press, 1969, pp. 1-57. A 12472 Carney, R. E., Feldman, H., and Loh, W. P. A 12457 SEX CHROMATIN, BODY-MASCULINITY AND SMOK- Zulch, K. J. ING BEHAVIOR. Paychological Reports_ GIBT ES BEZIEHUNGEN IN DEN BEFUNDEN DER 25(1):261-2, Aug 1969. EXPERIMENTELLEN UND SPONTANEN NEUROGENEN TUMOREN? (CAN THE FINDINGS IN EXPERI- MENTAL AND SPONTANEOUS NEUROOENIC TUMORS A 12474 BE RELATED?) Arzneimittel-Forachung Baratta, E. -I., Apidianakis, J. C., and 19(9),1503 -8, Sep 1969, German (Abs.) Ferri, E. 5. CESIUM-137, LEAD-210 AND POLONIUM-210 Report on the observations of CONCENTRATIONS IN SELECTED HUMAN TISSUES experimental neurogenic tumors and IN THE UNITED STAT5S,American Industrial their bearings for the brain tumor Hygiene Associatl,n Journal (0)1443-6, problems in man.Discussion of our Sep-Ocr 1969. present concept of the origin of spontaneous human Antracranial blastomas. (Author Abstract) A 12478 McSweeney, E. D., Jr. and Fletcher, W. S. SYNTHETIC ESTROGEN-PROOESTIN COMBINATIONS. A 12461 Effect on Hormone-sensitive Breast Cancer Woods, D. A. in the Rat. Archives of Surgery 99(5)r INFLUENCE OF ANTILYMPHOCYTE SERUM ON 652-4, Nov DMA INDUCTION OF ORAL CARCINOMAS. Nature 224(5216)1276-7, Oot 18, 1969. A 12483 Alfred, L. J., Donovan, P. J.. Baker, M. S., A 12463 and DiPaolo, J. A. Roastio, A. Morris, H. P., and Weinhouse, S. PROTECTION OF CULTURED HAMSTER EMBRYONIC LACTATE DEHYDROOENASE SUBUNITS IN NCRMAL CELLS FROM 7,12-DIMETHMENZ(a)ANTHRACENE AND NEOPLASTIC TISSUES OF THE RAT. CYTOTOXIC1TY AND THE INDUCED SYNTHESIS Cancer Research 29(9)11673-80, Sep 1969. OF ARYL HYLROXYLASE. Cancer Research 29(10)11805-9, Oct 19677----

A 12464 Stern, E., Mickey, M. R., and Gorski, A 12464 R. A. Henning!, H., Bowden, G. T., and NEUROENDOCRINE FACTORS IN EXPERIMENTAL Boutwell, R. K. CARCINOGENESIS. Annals of the New York THE EFFECT OF CROTON OIL PRETREATMENT CN Academy of Sciencirra(2714W-TON, SKIN TUMOR INITIATION IN MICE.Cancer 14, 1969. Research 29(10)11773-80, Oct 19617----

A 12468 A 124 88 Kaveteky, R. E., Turkevich, N. M., Akimova, Levi, I. S., Durst, A., and Polliack, A. R. N., Kheyetsky, I. K., and Matveichuck, THE EFFECT OF nASTRATION ON CHEMICAL Y. D. CARCINOOLNESIS IN THS CHEEK POUCH OF THE INDUCED CARCINOOENESIS UNDER VARIOUS MALE SYRIAN GOLDEN HAMSTER. Oral Surgery, INFLUENCES OF THE HYPOTHALAMUS. Annals Oral Medicine and Oral Pathology N6)1 of the New York Academy of Sciepces 771:12;77ETT9S9: rriT271517-4715eL 14,191T.

77 A 12490 A 12506 (continued) Gorski, T. role in the pathogenesis of cirrhosis. BIOLOGICAL ROLE OF CHARGE TRANSFER Despite elimination of intoxication, the COMPLEXES OF AROMATIC HYDROCARBON CXI- rate display a progress of the proceed. DERIVATIVES IN CHEMICAL CARCINOGENESIS. Investigations demonstrated that laultsJi_e16(4):403-8, 1969. heliotrine affections of the liver in rate may serve as a convenient model for studying the autoimmunidation in cirrhoses. A 12492 (Author Abstract) Davidson, A., Thomas, C. G., Jr., and Owen, J. EFFECT OF SURGICAL TRAUMA CN 7,12- A 12508 DIMETHYLBENZANTHRACENE INDUCED BREAST Chiancone, F. M. and Bonollo, L. CANCER IN THE SPRAOUE-DAWLEY RAT. FUMO DI TABACCO, NICOTINA E METABOLISMO Surgical Forum 20:105-6, 1969. DEL TRIPTOFANO. (TOBACCO SMOKING, NICOTINE AND TRYPTOPHAN METABOLISM.) Acta Vitaminologica et Enrymolooica A 12494 237-4):105-10, 19r9, Italian labs.) Wheatley, D. N. and Sims, P. COMPARISON OF THE EFFICACY OF PRETREAT- Studies on the relationships between MENT PROTECTION AOAINST ADRENAL NECROSIS tobacco smoking and nicotine on one hand INDUCE!? BY 7-HYIEOXYMETHYL-12-METHYL- and tryptophan metabolism on the other, BENZ(a)ANTHRACENE AND BY 7-METHYL-12- have mainly concerned the metabolic route METHYMENZ(a)ANTHRACENE IN RATS of hydroxylation of the amino acid. The Biochemical-Pharmacology 18(10)6585-7, latest studies which are reviewed here Dot 1969. demonstrate that smoking has no effect on urinary excretion of 5-0H-indoleacetic acid.Nicotine is, however, one of the A 12495 compounds which can induce 5-0H-tryptamine Epetein, S. S. release by a mechanism which is still CHEMICAL HAZARDS IN THE HUMAN under study.Research has been performed ENVIRONMENT. CA 19(5):277-81, on tryptophan decarboxylation by determi- Sep-Oct 1969. nation of tryptamine in urine and higher levels, increasing with the number of cigarettes smoked, have been found in A 12506 smokers. These data are discussed in- Levin, G. S., Rasulev, M3. I., Malsteev, terpretatively.The number and variety V. M., and Sultanov, S. A. of the mechanisms which may be involved f(**OnrylUXECIOIDEMWAAKAM PACT14" show the complexity of the problem and VIIVIOJUKIXECKYIKX KAV#1,0MaiK that our available wledge of it is IlATOCEME3E1EMOTP4fiXXXWFV30b. slight or even non-existent. In evalu- SMYIER44O-CAJVH0-10241010nepUmIc MX,JEAUKNitE. ating the results of studies on man, it is necessary to bear in mind the MORFOLCOICKESKIYE PRIZNAXI Y CHASTIYA concept of biochemical individuality, IMMUNOLCOICKESKIKH MEKHANIZMOV V i.e. of metabolic response to a given PATOGENEZE ULIOTRINNYKH TSIRROZOV stimulus according to an individual PECHENI.Ekeperimental,no- modulus for the subject in question. Morfologicheskoye Issledovaniye. (MORPHOLOGICAL SIONS OF PARTICIPATICN OF IMMUNOLOGICAL MECHANISMS IN THE A 12509 PATHOGENESIS OF HELIOIRINE CIRRHOSES Likhachev, A. Ya. OF THE LIVER, Experimental-Morphological WWTOHNTHE3YKRK f1PNKOMIVHIPCOKIMCM Examination.) Arkhiv Patolo it 31(8): 41,071,341 H-2-41.AgFEHNIATCETN4VAN 62-8, 1969, RusrrarA a. K4MTKOCOVETKN*VHA. BIASTOMOOENEZ U KAYS PRI KOMBINIROVANNOM Signs of reaction of retarded DEYSTVII N-2-FLUORENILATSETAVIDA I hypersensitivity were found in the liver N-NITROZOD1METILAMINA. (BLASTOMOOENESIS of 146 Wistar rats with heliotrine IN RATS IN THE COMBINED EFFECT OF N-2- hepatitis: diffuse lymphoplasmooytic in- AMINE.) AND N-NITROSODIMETHYL- filtration, pyroninophilia of hepatocytes AMINE.) Voprosy Onkolo 15(9)i65-9, and mesenchymal elements, formation of 1969, Russian (bs. the so called false bile tracts, etc. Lymphoidocellular reaction consisting in The experiments with the combined the fact that hepatic cello are surrounded effect of two carcinogenic compounds by a "bulkhead", become delimited and N-2-fluorenylacetamide (2-FAA) and N- later necrotic, is in many ways similar to nitrosodimethylamine (DMNA) on rats have the reaction of discarding of a homo- demonstrated that in DMNA injection in trasplant, and apparently, plays a definite combination with 2-FAA the incidence of A 12509 (continued) A 12520 hepatic tumors was found to be the same Garcia Echeverria, J. P. (29.6±9.6 percent) as in injection of ALOO MAS SOBRE EL HABITO DE FUMA. ERNA solely, but in a double dose (SOME MORE ON THE SMOKING HABIT.) (26.7±11.8 percent). An additive effect Medicine 36(11)11563-4, 1566, Nov 1968, was manifested inthe increased incidence Spanish (Abs.) of neoplasms of all localizations. (Author Abstract). The author has conducted his own tests on various commercial btands of cigarettes, with and without filters, A 12512 with and without holders, and smoked to Braga, M., Trompeo, G., and Vanini, O. C. various butt lengtha in a smoking machine PRIME RICERCHE SULL'INQUINAMENTO DA in order to determine the "nicotinic" IDROCARBURI POLICICLICI AROMATIC' resi' a collecting in the butts or con- NELL'ATMOSFERA URBANA DI TORINO. (FIRST taine4 in the "sterile" gas passing INVESTIOATIORS ON THE POLLUTION OF THE through the mouth end of the cigarette. AIR OF TURIN BY POLYCYCLIC AROMATIC Brenda were not identified, precise HYDROCARBONS.) I iene Moderna 611-2): numerical data were lacking, and admitted- 27-45, Sep 1, 196, an e. ly the results have not been entirely consistent.However, he observed that The authors inveatigated some factors when a cigarette without filter 111 smoked that exert an influence on the pollution up to the filter, the quantity which is of the air by aromatic polycyclic hydro- left in the gas (and which may be inhaled carbons, and they describe the first by the smoker) is two to three times investigations they made on the air of higher than when smoked without a filter Turin. They describe how and in which leaving a butt length of three centimeters. places dust samples were taken, the He concluded that brand differences exist determination by gas ahrcgoalograOhy is in the inhalation and the quantity of dealt with, and the qualitative analysis nicotinic residue which enter the organism of the first 55 investigations is comment- in the act of smoking, the least harmful ed on. (Author Abstraot) cigarettes being those with longer butt lengths.

A 12514 Turusov, V. S. A 12528 0)kretrAM C,CPAPME.11,m0r0PEHTfcm054K0c0 TJrbiner, S. and Shklar, G. 0511Y4X04t1A KAPE30P6TCHiX 7,12-.04467WEEK3(A) VARIATIONS IN EXPERIMENTAL CARCINOOENESIS ARITATOO-AX KO3XE MCKEE+. OF SUBMANDIBULAR OLAND IN THREE STRAINS OF 0 VLIYANII PREDVARITEL'NOGO RATS.Archives of Oral Biology 14(9): RENTOENOVSKOGO OBLUCHENIYA NA REZORBTSIYU 1065-717Srp1963; 7,12-DIMETILBEN2WANTRATSENA V KOZHE MYSKEY. (ON THE !MOT OF PRELIMINARY X-RAY IRRADIATION ON RESORPTICN OF 7,12- A 12529 DIMETHYLBENZWANTHRACENE IN MICE SKIN.) Lawther, P. J. VozpA'COgli15(9):45-9, 1969, OCCUPATIONAL HEALTH.Medical Annual RrinWt TKW.1 87:337-47, 1969. The intensity of fluorescence of skin in living mice after application of A 12532 various doses of 7,12-dimethylbenz(a)- Linnell, J. C., MacKenzie, H. M., Wilscl, J., anthracene was studied by a quantitative and Matthews, D. M. method suggested by L. A. Anclriyanov. PATTERNS OF PLASMA COBALAMINS IN CONTROL Irradiation in doses 2000 and 4000 r SUBJECTS AND IN CASES OF VITAMIN B12 immediately prior to application of DMBA DEFICIENCY. Journal of Clinical Pathology rendered no significant effect on duration 22(5)1545-50,er=176g7 of its fluorescence on the skin. In application of DMEA a week following irradiation in various doses of a car- A 12534 cinogen a considerably longer time of its Rakusan, K. and du Meenil de Rochemonl, W. fluorescence in comparison with control CAPILLARIES IN HEART AND SKELETAL MUSCLE animals wee noted. The increased period OF DOG AND RABBIT. (31865). Proceedings of DMBA fluorescence in previously of the Society for Experimental Biology irradiated skin is related to destructive and-Wdlcine 12r1b8-40, 1967. changes in tisaues, induced by radiation, and continuous fixation of the carcinogen in them. (Author Abstract) A 12555 A 12555 (continued) U.S. Department oi Health, Education and Welfare, Public Health Service. The influence of theFlafraction SMOKING AND HEALTH EXPERIMENTS, DEMON- of homologous and heterologous hie- STRATIONS AND EXHIBITS. U.S. Department tones (from calf thymus tissue) and of Health, Education, and Welfare, of a carcinogen 3,4-benzopyrene on Public Health Service, National Clearing- lung cells of guinea-pig embryos was house for Smoking and Health, Arlington, studied throughout a prolonged cultiva- Virginia, Public Health Service Publica- tion in vitro. Histones, especially tion No. 1843, July 1969. 21 p. heter3ToTOUTones. blocked cell multi- plication; the proliferation, however, A 12540 was restored after removal of the Sander, J. and Burkle, O. preparation from the medium. 3,4- ENDUKTION MALIONER TUMOREN BEI RATTEN Benzopyrene was found to exert a toxic DURCH GLE/CHZEITIGE VERFUTTERUNG VON but not malignizing effect on cells NITRIT UND SEKUNDAREN AMINEN. (L RUCTION in vitro.Irrespective of the mode OF MALIGNANT TUMORS IN RATS BY SIMULTA- or FUTTivation, medium composition NEOUS FEEDING OF NITRITE AND SECONDARY and of the influences applied, some AMINES.) Zeitschrift fur KrebaforachunK particular changes of the karyotype were 73(1):54-6t, 1969, German twos. noted during the cell proliferation in vitro. A 32-33 months cultivation of Feeding of morpholine and nitrite or guinea -pig embryo cells failed to lead N-methylbenzylamine and nitrite induced to the formation of continuous cell malignant tumors in rats. It was thus lines. (Author Abstract) proved, that carcinogenic nitrosocompounds may be formed in-vivo. Possible practical consaWences of these A 12562 results are suggested. The pathological Brookes, P. and Dipple, A. anatomical findings are shown. (Author USE OF MOUSE EMBRYO CELL CULTURES IN Abstract) THE STUDY OF HYDROCARBON CARCINOGENESIS. British Em ire Cancer Campaign for TOTEFFEh, nnuar rimiiz-rk 46:3, 'Org. A 12545 Fishlock, J. D. THE PHARMACOLOGY OF COLONIC MUSCLE. A 12363 Journal of the Ro1 College of Boyland, E., Pound, S., and Sims, P. cur eoneof'dinur 1415):271 -4, EFFECT OF 7,12-DIMETRYLBENZ(a)- ANTHRACENE DERIVATIVES ON TN! LYSOSOME -RICH FRACTION OF FEMALE RAT ADRENAL GLANDS. British Em ire A 12546 Cancer Campaign f3715(Fniwc , Green, M. and Behrendt, H. Magi 14291146777:3737617- SUEATINU CAPACITY OF NEONATES. Nicotine- Induced AAon Reflex Sweating and the Histamine Flare. American Journal of A 12564 Diseases of Children 116(0:725-32,Rov Dipple, A. and Brookes, P. 1967. 7-8ROMOMETHYIBENZ(a)ANTHRACENE AND 7-BROMOMETHYL-12-k8THYLEENZ(a)- ANTBRACENE. British Em ire Canc.: A 12555 Campaign forETEN KFEh, nnuarTnUrt Gudima,0. 5. and Aehmarin, I. P. 46:2, 19637- PA1411ThE KJETOt EMEWCHCK HOPCKVIKX O,14-10K Hit :141TPO X1 144Ati&E HA ETOT nPOTCECC rC1D-1 rErEPOIONWECKVKArtiCTCA-(14 N 3,14-E0.13111PEHA. A 12565 Sims, P. and Grover, P. L. RAZVITIYE KLETOK EMBRIONOV MORSKIKH ENZYME-CATALYSED REACTIONS OF SVINOK IN VITRO I VLIYANIYE NA ETOT POLYCYCLIC HYDROCARBONS WITH DNA PROTSESS-OAT GE1EROLOGICHESKIKH AND PROTEIN. British Em irt Cancer GISTONOV I 3,4-BENZPIRENA. (DEVELOP- Cappalgri for WM/FM nnua Report MENT OF GUINEA -PIa EMBRYO CELLS IN 46:4, 19637- VITRO AND THE INFLUENCE OF HOMOLt3OUS XRD-RETEROLOGOUS HISTONES AND 3,4- BENZOPYRENE ON THIS PROCESS.) Tsitologiie 11(9):1112-20, 1969, Russian tans.)

eo A 12566 A 1Z.573 Oorrod, J. W., Carter, R. L., and Wells, A. B. Roe, F. J. C. CELL POPULATION KINETICS OF THE INDUCTION OF HEPATOMAS BY 4-AMTNOBIPHENYL MACHEOBRONCHIAL EPITHELIUM OF AND THREE OF ITS HYDROXYLATED DERIVATIVES FATS AND HAMSTERS EXPOSED TO ADMINISTERED TO NEWBORN MICE.British CIGARETTE SMOKE AND OTHER AOENTS. Empire Cancer CampaignforrReseF7 British Empire Cancer Campaign 5for nnue Fan4635-7l . Annuarnarrb, 486s7 77968.

A 12567 A 12574 Booth, J. and Boyland, E. Bloom, H. J. O. and Stephens, E. J. W. METABOLISM OF NICOTINE. British EXPERIMENTAL RENAL TUMORS. British Em ire Cancer Campaign for Empire Cancer Campaign for RPREFEE nn Rep 46110, 1.9rr nnuaFetritor 46in, -PAT:

A 12568 A 12575 Paasey, R. D., neon, L. A., Jones, Swann, P. P. and Magee, P. N. R., and Bette, T. ALKYLATION REACTIONS IN CARCINOGENESIS. PLANT SUGARS IN CIGARETTE TOBACCO. Britian gmplre Cancer Ca i for68. British Empire Cancer Campaign for refiErl.c17kffniTal-Freror rainh, AnnuaY-plZit 46f10-1,

A 12576 Stewart, B. and Magee, P. N. A 12569 EFFECTS OF INHIBITORS OF NUCLEIC ACID Pylev, L. N., Warwick, O. P., and Roe, AND PROTEIN SYNTHESIS CN CARCINOOENESIS. F. J. C. British Empire Cancer Campaign for EFFECT OF ASBESTOS DUST OR CARECN eye r&Annual Report 4611W-37- BLACK ON DISTRIBUTION OF TRITIATED 113117' 5,4-BENEOPYRENEFOLICWINOA SINGLE INTRATRACHEAL INSTILLATION IN IAMSTMS. British Em ire Cancer A 12577 Campaign torn:I-Ere nniarnport Dickens, F., Itaynforth, H. B., and 46:11, 19rg7 Parkin, R. INTRATRACHEAL ADOINISTRATION OF DUST PARTICLES AND CARCINOGENS IN RATS. A 12570 British Em ire Cancer camIm for Stock, J. ,.. snd Haddow, A. PraTIFFEh, nnuarire/7-ort 461108-171968. ATTEMPTS AT THE IMMUNOTHERAPY OF BENZOPYRENE RAT SARCOMAS. British Em ire Cancer PAMP8ign for RETBEFEh, A 12578 Anua /WM 46118;19Fr Powell, A. K. CARCINCOENIC ACTION OF RIBONUCLEASE ON CELLS IN VITRO. British Em Ire A 12571 Cancer Car5ani-roreeearc nnual Weston, B. J., Davies, A. J. S., and firel 461128", 1911r. Roe, F. J. C. IMMUNOSUPPRESSION BY HYDROCARBONS. British Em ire Cancer Ca si for A 12579 nnuar1T-Zrt- , r3r8. Cohen, B. INVESTIOATICN INTO CARCINOGENIC EFFECTS OF CHEWING TOBACCO. British Em ire A 12572 Cancer Camialgn for RETEFFEE nnua Roe, F. J. C. and Orant, O. A. METE rrfriTi,-Igrk. COMPARISON BETWEEN THE EFFECTS OF A SINGLE DOSE OP A CARCINOGENIC HYDROCARBON IN ONOTOBIOTIC AND A 12580 CONVENTIONAL MICE.British Em ire Olucksmann, A. and Cherry, C. P. Cancer Campaign fo. RITaanh, nnual EFFECT OF DECREASINO THE NUMBER OF DMBA Reece 46154-5, i71r8. APPLICATIONS ON THE INDUCTION OF CERVICO- VAOINAL AND VULVAL TUMOURS IN CASTRATE RATS. British Empire Cancer Campaign for Rep atiocE",-Winuar-RiErriging-r, 14687

el 85 A 12581 A 12596 Olucksmann, A. and Cherry, C. P. Nothdurft, H. INFLUENCE OF VARIATION IN OESTROGENIC UBER DIE SARKOMAUSLOSUNO DURCH STIMULATION ON THE INDUCTION OF FREMDKORPERIMPLANTATIONEN BEI FLATTEN CERVICO-VAGINAL TUMOURS IN RATS. IN ABHANGIOKEIT VON DER FORM DER British Empire Cancer gaTpagE for IMPLANTATE. (DEPENDENCE ON SHAPE RaTerfah,AnnualT-RZTRIrt 81 2 ,7558. FOR THE DEVELOPMENT OF SARCOMATA BY IMPLANTATION OF FOREIGN BODIES.) Naturwiasenschaften 42,106, 1955, A 12582 ilerman (Abs.) Glucksmann, A. and Cherry, C. P. PERINATAL MODIFICATION OF THE ENDOCRINE Polystyrene, cellulose hydrate and STATUS OF RATS AND ITS EFFECT ON THE polyvinyl chloride polymers in the form INDUCTION OF TUMOURS. British Em ire of circular dicks, rods or spheres, Cancer Cam 1 for ResiE1757Annue powders and bristles were implanted, e,rnor - ,-T9-6137 intraperitoneally or subcutaneously, in a total of 1104 Wistar Rats.A total of 123 sarcomas thus far, developed.Only A 12583 3 resulted from powder clumps and these Clays m, D. B. and Wood, M. developed 14 to 15 months after implan- CARCINOGENICITY TESTS IN MICE.British tation. No tumors developed within 19

Em ire Cancer CEmpa1-iD36tilr for RereaFFE7--- months from dispersed powders. Smooth nnua ala :2 - ,-Igt/C7 unperforated disks pro4,:ced 70 sarcomas (54 subcutaneous); perforated disks, 57 sarcomas (29 subcutaneous). Rode, A 12585 ap4eres and bristles, yielded only 13 Craig, A. W. and Bertram, J. S. sarcomas. The results of other investi- METABOLISM OF DIBUTYLNITROSAMINE. gators veins other materials were also British Empire CancerCampaignfor mentioned. STFEinh, AnnuarinFartSi -2,7;88.

A 12599 A 12586 Boletim do Institute Portugues de Oncologia Jackson, H. and Edwards, K. de Francisco Oentil. ANTISPERMATOOENIC EFFECTS OF POLYCYLIC COMO 0 PICK NEVOELRO MOLES. (LIKE THE HYDROCARBONS. British Empire Cancer WORST ENGLISH FOG.)Boletim do Inetituto Campaign for Research Annual Rego Portugues de Oncologirdirlrfaririsco asals; mg. Uentl: 35(37:3-4, Tun in.87wrquise trsm

A 12593 The harmful constituents of the DelmerD. P. and Mills, S. E. smoke of tobacco (and cigarette paper) PRIPTOPHAN SYNTHASE FROM NICOTIANA and their action on the human organism TABACUM. Biochemica et Bib sica were described briefly. It was t.oncluded Acta 167(2):431-43, 0T 8, that filters had insufficient capabilnies in removing the deleterious components of tobacco smoke. Present efforts in reduc- A 12594 ing the risks of smoking are being Zielke, H. R., Byerrum, R. U., O'Neal, directed towards (1) suppressing benzo- R. M., Burns, L. C., and Koeppe, R. E. pyrene and related substances by aub- INCOPPORATION OF CARBON DIOXIDE AND stances added to tobacco, (2) lowering ACETATE INTO THE PYRROLIDINE RING OF the temperature by additives to tobacco, NICOTINE. Journal of Biological (3) aelection of leas harmful tobaccos, Chemistry 243(18):4757-61, Sep 25, 1968. and (4) modifying the treatment of tobacco from culture to cure.

A 12695 Oppenheimer, B. S., Oppenheimer, E. T., A 12601 and Stout, A. P. Lacassagne, A., chemorro, A., Hurst, L., SARCOMAS INDUCED IN RODENTS BY IMBEDDING and Oiao, N.-B. VARIOUS PLASTIC FILMS. Proceedings of EFFET DE L'EPIPHYSECTOMIE SUR the Society for Experimental Biold,gy-Sbd L'HEPATCCANCERQGENESECHIMIQUE, Racine (9:35T-9, 1952. CHEZ LE RAT. (EFFECT OF EPIPHYSECTOMY ON CHEMICAL HEPATOCARCINOGENESIS IN RATS.) Com tee Rendus Hebdomadaires des Seances e TATEffinle des sciences; urallwrallmtamirmspac434, rep 15, 19697-F7TRECAb3. A 12601 (continued) A 12606 (continued) tension, the effect of some drugs on Ten of 12 male Water Rats who had catecholamine excretion, action of block- undergone pinsalectomy were later sub- ing and releasing drugs, and circadian mitted to a diet low in protein and rhythm; (3) studies on patients with riboflavin and fed the following toxic pheochromocytoma concerning diagnosis of substances: 4 animals (1 died) with the disease, excretion of dopamine, 4-dimethylaminoazobenzene (DAB)and 3 localization studies, pharmacological with 2-acetylaminofluorene (AAF 1, and tests, circadian rhythm, the effects of 2 with diethylnitroaamine 0)ENA , some drugs, and in vitro incubation; (4) multiple hepatomas developed in the studies on cardiac EKTiEholamines in dog animals fed AAF and DENA but canceriza- and sheep hearte, cardiac catecholamines tion was prevented in those given DAB. following experimentally induced The adrenals were normal in weight in infarcts, the effect of some drugs on controls and DENA animals, heavier in cardiac catecholamines, and tissue AAF animals and reduced in DAB animals. catecholamine from biopeiee of human The results of the histological examina- auricula cordial (5) physiopathological tion were also noted. studies dealing with monossmine excretion in patients with hyperthyroidism and myxedema, surgeons and surgical patients, A 12602 and patients with pulmonary disease, Conney, A. H. tissue amines under conditions of ENZYMINDUKTION DURCH ARZNEIM7TTEL BEIM hypoxia and anoxia, and the action of KENSCHEN. (INDUCTION OF ENZYMES BY thiazides on tissue catecholamines of DRUGS IN HUMANS.)Deutsche Apotheker- the rat; and (6) aeurohormonal studies Zietu 109(36):1437407TITP161 1969, concerning the concentration of serotonin erman (Abs.) in cerebral regions of the dog, the effect of thyroidectomy on cerebral The effects of vario.ls drugs as well aerotonin of the dog, and the effect of as cigarette smoking were briefly re- sleep deprivation on monoamines in the viewed. Cigarette smoking increases the cat. hydroxylation of 3,4-benzopyrene and the N-demethylation of the dye, 3-methyl monomethylaminoazobenzene by enzymes A 12613 present in the human placenta. Various ()argue, J. L., Paynter, O. E., and Reese, aromatic polycyclic compounds increase N. H. Jr. considerably the benzopyrene hydroxylase UTILIZATION OF imam; MICE IN THE activity In rat liver and it le apparent BIOASSAY OF CHEMICAL CARCINOGENS. that the same components of tobacco smoke Toxicology and Applied Pharmacology have the ease effect in human placenta. 15(3):552-97Tov 19E9. Further study is indicated to learn whether the high variability in the induction of the carcinogen-metabolizing A 12614 enzyme can explain the susceptibility of Macnicol, P. K. individuate to the action of chemical ISOLATION OF 6-HYDROXYKYNURENIC ACID carcinogens in their environment. FROM THE TOBACCO LEAF. Biochemical Journal 107(4):473-9,

A 12606 Serrano, P. A. A 12615 EVOLUCION A DIEZ ANDS DE LDS ESTUDIOS Goldenberg, M. M. REALIZADOS SOBRE MONOAMINAS. (TEN-YEAR TACHYPHYLAXIS TO THE INHIBITORY EVOLUTION OF THE STUDIES CARRIED OUT ACTION OF ATROPINE ON THE CHOLINEROIC ON MONOAMINES.) Oaceta Modica de Mexico RESPONSE TO NICOTINE, IN VITRO. 99(3)1310-24, Mar-r9 77 rarireds -tArer.7 Archives InternationaliTa--- PMERWidynamie et de Inentle, A survey is made of the panorama of 150(2):?61-80, Aug inv. investigations on monoamines conducted over the past 10 years. These includes (1) studies with normal subjects in- A 12616 volving the development of new techniques Orientacion Medic*. for determining catecholamines, 5- ACCION FARMACOLOGICA DE Lk NICOTINA., hydroxyindole acetic acid and serotonin (PHARMACOLOOICAL ACTION Or NICOTINE.) in urine, blood and tissue, circadian Orientacion Medics 16(653)i412, May rhythm, and monoamine excretion in 3137T5T97-rpinib(Abs.) smokers) (2) studies on essential hypertension dealing with excretion of A study on the amount and rate of catecholamines and the degree of hyper- nicotine absorbed by a smoker revealed

4037 A 12616 (continued) A 12654 that the average smoker inhales 1-2 Sims, P. times per minute and inhales about 25 ml METABOLISM OF BENZO(OPYRENE.British of smoke per inhalation; that an inhala- Empire Cancer Ca i or BeasiMg-- tion of 35 ml produces twice as much nnue 11756FE sr ./7-r957:- nicotine as one of 20 ml; and that in 10 minutes a smoker takes in 1-2 mg of nicotine.A atudy on cats comparing the A 12635 action of nicotine in inhaled cigarette Green, B. smoke on arterial pressure with that of PHYSIOCHEMICAL REACTIONS OF CARCINOGENS intravenously injected nicotine showed WITH DNA.priti4Ogilipire Cancer both modes to cause about the same rapid camausroF-w-xil.e.naTlEaLl rise in arterial pressure. An investiga- 451. -12-277n- tion on the calming or stimulating effects of nicotine on excited rats taught to drink water by pressing a receptacle, A 12636 showed that intravenous injections of 0.5 Sims, P. and Grover, P. L. mg nicotine every 30 seconds for 20 FACTORS AFFECTING THE METABOLISM OF minutes caused a 78 percent increase in 7,12-DIMETHYLBENZ(a)ANTHRACENE (DMBA) the number of presses on the receptacle BY LIVER PREPARATIMS.British for most rats. Experiments on cats, Em ire Cancer Ca ign TUFTWITiarch, demonstrated that nicotine injections can Annual RT56Fr ar 77r6=4771967. either elevate or lower the rate of acetylcholine liberated in the cerebral lup4rficies with parallel modifications A 12637 oi the EEO. The rise in cortical activity, Brookes, P. and Dipple, A. analogous with that provoked by injections MECHANISM OF HYDROCARBON CARCINOGENESIS. of nicotine in the cat, could explain the British Em ire Cancer Ca I for subjective impression of greater capacity ee nnuartleiror art77 : for concentration or better efficiency. 20, 1967. Such effects of nicotine Inan probably depend on the quantity and frequency or self-administration as well as the pey- A 12638 cholodical conditions of the moment. Booth, J. and Boylend, E. NICOT/NE METABOLISM. British Em ire Cancer Campaign for ReTWEIT; nnua A 12619 REF 15(Part British Empire Cancer Campaign Annual Report. EFFECT OF moms TOBACCO SMOKE A 12639 CCJDENSATE IN YOUNG MICE.British Paseey, R. D. and Warbrick-Smith, D. Empire Cancer ;Icilignfor ARUM, TYPES OF TOBACCO AND LUNG CANCER. Annualtypal r pm, 1965. British Empire Cancer Campaign for Frarrh'oi,77911vuarigrort 49Fiirt-27: 26, 1967. A 12620 Black, D. K. and Dickens, F. STUDIES ON CIGARETTE-SMOKE CONDENSATE A 12640 AND ITS COMPONENTS:INTERACTIONS WITH Stock, J. A. and Haddow, A. CYSTEINE OF SOME CARCINOGENIC COMPOUNDS. .CTIVS IMMUNISATION AGAINST BENZOPYRENE British Empira Cancer qa_Laign Lot SARCOMAS. British Empire Cancer Campaign WITIEF017-KOUST1RT56rT7T3TPIFt-2-7422, for ResearcgrnErial Report-ISTArt 2)i 91 55. 715717-13177-

A 12632 A 12641 Michie, M. J. and Reid, W. W. Haddow, A., Stock, J. A. and Smith, C. BIOSYNTHESIS OF COMPLEX TERPENES IN THE ATTEMPTS AT THE DIMUNOTHERAPY OF LEAF CUTICLE AND TRICHOMES OF NICOTIANA BENZOPYRENERADT S AR1CO15M11 A Sfo. BriM TABACUM.Nature 218(5141)$5787KET--- Con r TTrrin. Ann moo 1v 7771767

A 12633 A 12642 Eichel, B. and Arto Shahrik, H. Cohen, B. and Smith, C. I. TOBACCO SMOKE TOXICITY: LOSS OF HUMAN INVESTIGATION INTO CARCINOGENIC EFFECTS ORAL USUKOCITS FUNCTION AND MID-CELL OF CHEWING TOBACCO. British Em Ire METABOLISM. Science 166(3911):1424-8, Cancer Campaign for RirreTrn,c, nnu Deo 12, 1969. RIB3FE 45(Fart 27T52, 1967. A 12643 A 12653 Iball, J. Boyland, E., Nery, R. and Williams, K. X-RAY CRYSTAL ANALYSIS OF CARCINOGENIC METABOLISM OF URETHANE AND AND RELATED COMPOUNDS. 1,2,5,6- HYDROXYURETHANE. British Em ire Dibenzanthracene.British Empire Cancer Cancer Campaign forRnErrc , Annual Cam i for ResearETT-EFffual eporTIE- Report 44 (Part 2734, 1965. r :3Lr,3767.

A 12654 A 12646 Weaton, B. J., Davies, A. J. S., and Roe, Boletim do Institute Portugues de Oncologia F. J. C. de Francisco Oentil, EFFECT OF NEONATALLY ADMINISTERED A PROPOSITO DE TABACO NO CANCRO EXPERI- CHEMICAL CARCINOGENS ON IMMUNE MENTAL E NO CANCRO HUMANO. (ON TOBACCO COMPETENCE OF MICE. British Em ire IN EXPERIMENTAL AND HUMAN CANCER.) Cancer Campaign for Reeanac,nnu Boletim do Instituto Port es de frific.44tPart27T313, 2966. 817631-6ggrarYfrEnTcoenzli ) :11- 2, Jul19617ITTEUZUFge-TATIF7) A 12655 Tracheas excised from rats (Murganhos) Wallin, V. and Koller, P. C. either shortly before or several days RADIATION-INDUCED LEUKAEMIA AND IMMUNE after birth were treated with tobacco RESPONSES. British Em ire Cancer smoke condensate in in vitro culture.The Cam i forlieTereriil,,c nnarTe5ort histological changes-inMI-epithelium and Part Tr587. cartilage of the excised tissue were noted. The epithelium showed higher secretory activity after 9 days and the mitotic A 12656 index rose from 0.21 percent from the 9th Cobb, L. M. day to 0.37 percent after 17 days.The EXPERIMENTAL STUDIES. British Em ire rise in the mitotic rate, hyperplasia of Cancer Cam i for ResantrAnnua the basal cells, loss of secretory MIFF; ar 774/7071m. activity and other subsequent destructive changes in the epitheluim were noted.No degenerative changes in cartilage were A 12657 noted after 9 days of culture, but Roe, F. J. C. after 2 weeks, the chondrocytes degener- VALUE OF LABOPATORY ANIMALS AS MODELS ated and lost their powers of coloration. FOR TH: STUDY OF FACTORS INVOLVED IN The necrotic cartilage was invaded by THE CAUSATION OF HUMAN LUNG CANCER. fibroblasts from the connective tissue British Em ire Cancer Camppaniggn for situated between it and the epithelium. RTMITZ11 nnT-FaT7rt A comparison of these results with those 557r7gT: observed in human fetal lung tissue treated with benzopyrene and tracheal epithelium treated with carcinogenic hydro- A 12659 carbons, showed that thase agents first Hill, C. R. stimulated end then destroyed secretory ENVIRONMENTAL RADIOACTIVITY. British activity. In contrast, tobacco smoke Em ire Cancer Campaign for ResilaM7- hydrocarbons caused destructive changes nnua mom 44kpart721119; mr only in cartilage.

A 12660 A 12651 Bloom, H. J. O. and the Cheater Beatty Sims, P. Research Institute. METABOLISM AND CARCINOGENIC ACTIVITIES KIDNEY TUMOURS.British Em ire OF POLYCYCLIC HYDROCARBONS AND THEIR Cancer Campaign finTiTir-c Manual DERIVATIVES.British Empir: Cancer eA pow(ETTift-2117S , gamsaign for RilaTEK, Annu 17.10Ft 14iPart 2Tr-277=7 A 12661 Black, D. K. and Dickens F. A 12652 COMPONENTS or CIOARETTS SMOKE CONDENSATE. Walters, M. A. and Roe, F. J. C. British Empire Cancer Campaign for INDUCTION OF PARENCHYMAL -CELL HEPATOMAS rch, Annuarn5FrtaakFireTT: IN MICE BY CARCINOGENIC POLYCYCLIC Iva*. HYDROCARBONS. British Em ire Cancer Campaign for ReTFEFEE7 nnu KURT 44(Part 277,717V07-

35 A 12662 A 12671 Rasheed, S. Baldwin, R. W. and Barker, C. R. EFFECTS OF URETHANE ON CELLS CULTIVATED DELETION OF NORMAL LIVER CELL ANTIGENS IN VITRO. British Empire Cancer FROM CARCINOGEN-INDUCED HEPATOMAS.

CgM--r-Ffornalare , AnnUFT-Freport British ::mpixe Cvncer Campaign f7TMInTh_7lrnarIg6ri

ar 77royrrnr7 44(rart : 19-20, 1966.

A 12665 Lindop, P., Mendes, J. J. A., and A 12672 Rotblat, J. Searle, C. E. EFFECT OF CHEMICAL AGENTS AND RADIATION INHIBITION OF SKIN CARCINOGENESIS. ON THE INDUCTION OF LUNG TUMOURS. British Empire Cancer Campaign for British Empire Cancer Campaign for IreTearigirlarleUFrt44i15art127: FrelTEFEh, Annual7E1171'1 44tPart77: 30-1, 196r7---- 145-6-, 196r A 12673 A 12664 Flake, A. Sanderson, X. V. THYMUS AND CARCINOGENESIS. British ARSENIC IN CARCINOGENESIS IN MICE. Empire Cancer Cam 1 for RFFEEFEE, British Ermine Cancer Camoign for Annual erMor ar 772.58-9, 1966. MreMMer,-ral-PEirortWrt-27: 155, 1966. A 12674 Ohadially, F. N. and Roy, S. A 12665 SYNOVIAL SARCOMAS. British Em ire Mobbs, B. O. Cancer Campaign for 2171i761.1, Annual UPTAKE OF OVARIAN STEROIDS BY DMBA- RTWE44(Part 2772E2, 1966. INDUCED MAMMARY TUMOURS OF THE RAT. British Empire Cancer gsmpeigri tor nriTueh7A-5117.1arWort-Mieft-27: A 12675 165, 1966. Chalmers, J. O. TRYPTOPHAN METABOLITES IN UROLOOICAL PATIENTS. British Em ire Cancer A 12666 Ca 1 forTFIFErc ,nnilErnport Pryce, D. M. and Blenkineop, W. K. ar 1966. LUNG CANCER STUDIES.British Empire Cancer ca 1 for ReITErF61T7 Annuer MOTE ar Trr6brm3r7 A 12681 Paesey, R. D. and Blackmore, M. BIOLOGICAL EFFECTS OF CIGAR AND CIGARETTE A 12667 SMOKE. British DIpire Cancer Campaign Wright, E. C. and Hopewell, J. W. for ReseTIFEW7-EhnuEl-ReWrIMPart 2)s6, PRODUCTION OF EXPERIMENTAL CEREBRAL rgr67------TUMOURS IN RATS. British Em ire Cancer Cam i for ReseaFEETTffnua op5FE- ar 17767, 1966' A 12682 Paeeey, R. D., Elson, L. A., and Blackmore, M. A 12669 INVESTIGATION OF THE SUGAR CONTENT OF oOlucksmann, A. and Cherry, C. P. CIGARETTES OP DIFFERENT COUNTRIES. ENDOCRINE RESPONSES OF THE EPITHELIAL British Empire Cancer Campaign tor THYMUS IN THE RAT.British Em ire IWiEFEh, AnnuarTeWrE-7-T-IlaWYt-Fil Cancer Campaign for frilEiFEh, nnual b-7, 1966. is= ;Wart PTT211.:2, 1966. A 12683 A 12670 Lasnitzki, I. Olucksmann, A. and Cherry, C. P. EFFECT OF A 'HYDROCARBON ENRILHED" HORMONAL MODIFICATION OF INDUCED CIOARETTE SMOKE CONDENSATE di HUMAN AND CARCINOOENESIS IN THE RAT. British 24MSTER POSTAL LUNGS IN ORGAN CULTURE. Em ire Cancer Ca 1 for RFERFER, British Empire Cancer Campaign for nn trii375nrit r T7712-3, 1966. FaTincl, Annual-1757A vilFert -273 05, 1466.

86 90 A 12684 A 12696 Cohen, B., Smith, C. J., and Bruton, J. W. Matzinger, D. F. STUDIES IN ORAL CARCINOGENESIS.British GENETIC VARIABILITY IN FLUE-CURED Empir!. Cancer Campaign for Researrh,--- VARIETIES OF NICOTIANA TABACUM L. III. Annua RZTin44(Part 2171.31-2, 1965. SC58 X DIXIE BRIGHT 244.1;7171Ftedfrom Crop Science 8(6):732-5, 1968. Tobacco PrEFriltSTrrrerNo. 269. A 12685 Craig, A. W. and Clapp, N. K. CARCINOGENIC ACTION OF DIMETHYL- AND A 12697 DIETHYLNITROSAMINE IN THE RF MUSE. Matzinger, D. F. and Wernsman, E. A. British Empire Cancer Campaign for GENETIC DIVERSITY AND HETEROSIS IN regre17-hc7rnTiCa1717116rETITNTC127: NICOTIANA. II. ORIENTAL X FLUE- 1966. UUNED VARIETY CROSSES. Reprinted from Tobacco 167(13):52-5, 1968. Tobacco RPTTESeries No, 267. A 12686 Roe, F. J. C. MECHANISM OF CARCINOGENESIS BY THE A 12698 NEUTRAL FRACTION OF CIGARETTE SMOKE Bingham, E. and Falk, H. L. CONDENSATE. British Em ire Cancer ENVIRONMENTAL CARCINOGENS. The Cam 1 for FraTech- , nnuar-ReWirb Modifying Effect of Cocarcinogens r 175,711117-- on the Threshold Response. Archives of Environmental Health 19(6):779-15, Mc1969. A 12687 Boyland, E. and de Kock, D. H. NICOTINE METABOLISM. British Em ire A 12699 Cancer Cam i for ReirEFERT nnua Kaneko, H. and Mita, M. Report ar ITS-s,1966. ISOLATION FROM CIGAR TOBACCO LEAVES OF 2,3-DIMETHYL-4-HYDROXY-2-NONENOIC ACID LACTONE. AgTicultural and Biological A 12690 Chemistry ''.30):1525-67-Cfc't 1969. Burki, H. R. and Okita, G. T. EFFECT OF ORAL COPPER SULFATE ON 7,12- DIMETHYLBENZ(a)ANTHRAC&NE CARCINOGENESIS A 12700 IN MICE. Brirish Journal of Cancer Takayama, S. and Ojima, Y. 23(3)1591-6T-SETI969. PHOTOSENSITIZING ACTIVITY OF CARCINOGENIC AND NONCARCINOGENIC POLYCYCLIC HYDRO- CARBONS ON CULTURED CELLS. Japanese A 12694 Journal of Genetics 44(4):231-10, Gorski, T. Sep 1969. WSPOLCZESNE ZAGADNIENIA CHEMICZNEJ KANCEROGENEZY. (CURRENT PROBLEMS C7 CHEMICAL CARCINOGENESIS.)Pcsteay A 12701 14.14,:silly I Medycyny Doswiadczalnej Tarusov, B. N., Lomsadze, B. A., and 17567-S06, 1969, Polish (Abs.) Tsartsidze, M. A. SPECIFIC INTERACTION OF CARCINOGENIC A review of problems of the chemical HYDROCARBONS WITH LYSOSOMES. Translated carcinogenesia is presented.The from Doklad Akademii Nauk SSSR 178(6):

author's studies on the biological 1418- ,0, Feb113717-17oRIFTnrdemii role of charge transfer complexes of Nauk SSSR Biochemistry ec ion 176(1-6): aromatic hydrocarbons are did:missed. TVS, -7an -Feb1968. (Author Abstract)

A12702 A 12695 Olds, M. E. and Domino, E. F. Bhagat, B. DIFFERENTIAL EFFECTS OF CHOLINEROIC MECHANISM OF NICOTINE-INDUCED RELEASE OF AGCNISTS ON SELF-STIMULATION AND ESCAPE CATECHOIAMINES. Progress Report. New BEHAVIOR. Journal of Pharmacology and York Medical College, Department of _spEJerimentarlinTrapeutics 170(11:15r:- Pharmacology, Flower and Fifth Avenue 37, Wov Hospitals, New York, N.Y., for The period Jan 1, 1967-Jun 30, 1967, 2 pp.

87 9/ A 12704 A 12708 (continued) Ooodman, L. and Oilmen, A. disappeared from different organs of TOBACCO (NICOTINE). In: Resource Book rabbits more rapidly than from organs for Drug Abuse Eduoatton. U. S. Depart- of mice, rats, and dogs. Species ment of Health, Education, and Welfare, differences were noted at the level of Public Health Serw.ce, National Clearing- the accumulation of Po-210 in different house for Mental Health Information, organs and tissues as in kidneys of Chevy Chase, Md., Vublic Health Service rabbits, in spleens of doge, as wall as Publication No. 1964, Oct 1969, pp. 57.8. in other organs.

A 12707 A 12711 Astapova, S. A. Khachaturova, T. S. and Papoyan, S. A. MNIDIEME 06' 'bIEMA CO:Ya1CT0f0PYCAA COONEC1710be aacirmc AMICOMMITIA, nouxb(nFono:/oxDav n)-210. OCrIOXIATC14-HAM1t16VM4 IVIACECCKaimoro OnManfo6PA.30AoisvAY 61U1EX IZMENENIYE OB"YEMA SOSUDISTOGO RUSLA &OCHE:: PSI PORAZHEICI Po-210. (CHANGES IN SOMSTNOYE DEYSTVIYE VIRuSay GRIM, THE SIZE OF THE VASCULAR DUCT OF KIDNEYS OSPOVAKTSINNY I DMBA NA PROTSESS DURING Po-210 ATTACF.)Meditsinskaia KOZHNO00 OPUKHOLEOERAZOVANIYA U SELYKH Radiolo iia 24(9):69-71, lep 1969, MYSHEY. (JOINT ACTIVITY OF VIRUSES OF miss an (Ms.) INFLUENZA, SMALL PDX VACCINE AND DMEA ON THE SKIN TUMORIOENESIS PROCESS IN Male, white rats with the vascular WHITE MICE.) Zhurnal Ekaperimental'n network filled with 1 mixture of India 1 nin1cheskorgalli1F-79-0M0=8:-- ink and gelatin were exposed to chronic 1-09, Russian (Ate radiation with Polonium-210 (0.005 microcuries/g).Observations were rade Combined activity of viruaee of in- after 3 and 15 days (25-115 rads in fluenza, small pox vaccine and 13:42A re- kidneys) and after 200, 3C0 and 400 days sulted in an acceleration and a greatar (1400-1470 rade in kAney). The earlier incidence in the development of observations showed some necrotic changes papillomas and tumors as compared with and impairment of the permeability of the animals treated only with DAM. The vascular walls but with little change results were more pronounced wlnon DMBA (sometimes an increase) in the caliber of was combined with email pox vaccine virus the smaller vessels (arteries, arterioles than with influenza virus. and capillaries of siroma and glomeruli). Capillaries of the glomeruli appeared to be most severely damaged.Chronic exposure A 12712 to Po-210 resulted in exclusion from the Van Duuren, B. L., Conklin, M., Lavers, blood circulation of up to 50-75 percent G. C., and Segal, A. of the capillaries of the glomeruli and up SYNTHESIS OF LAURATE ESTERS OF PYROOALLOL to 50 percent, of the capillaries of the AND RELATED PHENOLS. Journal of the stroma. Chemical Society; sectibeM-OFEOW ynemlatry77) 7538-91577917. A 12708 Parfenov, Yu. D. Bed Poluboyarinova, Z. I. A'i2713 MtvoabbE PA3ait440,06rEe:rx)-2115 Tsuji, T., Segal, T., and Saito, T. CATAte43k AABCPA70P61Oc 364V3Tetox. UITRASTRUCTURE OF THREE TYPES 01 EPIDERMAL DENDRITIC CFLIS IN VIDOVYYE RAILICHIYA 05MENA Po-210 V HAIRLESS MICE. Journal of Investi- ORGANIZME LABORATORNYKR ZHIVOINYKH. ative DermatoloEintS)T352-4-67-- (SPECIES DIFFERENCES IN THE R2TABOLISM ov 6g7 OF Po-210 1N THE CROAIISM OF LABORATORY ANIMALS.)Radiobiolos0Miia 14):596-8,

Jul-Aug 196, Russian-o. . 12716 Mori, W. and Coombs, R. R. A. Po-210 was introduced by single DEMONSTRATION, BY THE MIXED ANT10LOBULIN subcutaneous inJectio0 in rats with RE'CTION, OF ANTIBODIES TO BP8 TUMOUR dosages of 0.01, 0.03. 0.035 and 0.075 CELLS IN IMMUNIZED MICE. British microcuries/g, in'rablIts 0.04 micro- Journal of Cancer 2:(3)1622:17-3FP 1969. curiee4g, and in dogs 0.025-0.5 microcuries/g. Data on Po-210 metabolism in the organs of mice were obtained from the woe.: A 12719 of Finkel et al (1953) with intravenous Beuving, L. J. .Jection BY We isotoYe.Results of EFFECTS OF OVARIECTOMY ON PRENE0- the experiments showed that Po-210 PLASTIC NODULE FORMATION AND

88 A 12719 (continued) A 12740 MAINTENANCE IN THE MAMMARY GLANDS Brown, A. S., Maitrya, B. B., and Hag, I. U. OF CARCINOGEN- TREATED RATS. BLOOD CARBOXYHEMOOLOBIN LEVEL IN BEEDI Journal of the National Cancer SMOKERS. Indian Journal of Medical rgErrute43117):1181-9, R37rgt9. Research 5717):1311-47,U117,617---

A 12720 A 12744 Beuving, L. J. Mesrobian, A. Z. and Shklar, G. RESPONSIVENESS CP CARCINOGEN- INDUCED LINOIVAL CARCINOGENESIS IN THE HAMSTER, HYPERPLASTIC ALVEOLAR NODULES IN USING TISSUE ADHESIVES FOR CARCINOGEN LEWIS RATS TO MAMMARY OLAND GROWTH- FIXATION. Journal of Periodontology. REGUIATCEY MECHANISMS. Journal of Periodontics 40110)115/603-48/606, Oct the National Cancer inelaturrTsm): 17717b1757i9ET7-- A 12745 A 12724 Kodama, M. and Nagata, C. Chiou, C. Y. and Long, J. P. PHOTOSENSITIZING EFFECTS OF AROMATIC ACETYLCHOLINE-RELEASING EFFECTS OF HYL,.00ARBONS AND QUINOLINES UPON DNA. SOME NICOTINIC AGENTS ON CHICK Chemico-Biological Interactions BIVEdTER CRVICIS NERVE MUSCLE 1(i):99-112, Oct 19g77------PREPARATION. ProceedinAa of the Society for ExPrilienTLY-BT61517 and Medan& 132(2)1732-7, Nov1969. A 12747 Convey, A. H. MICROSOMAL ENZYME INDUCTION BY DRUGS. A 12727 Pharmacoln for Phyaicians 3(12): Fujimoto, K. - , Dec LW 9. COMPARATIVE STUDIES OF THE ADEENERGIC RELAXATICVS IN THE EXCISED JEJUNUM OF RAT, EVOKED BY NICOTINE, TYRAMINE, A 12750 HISTAMINE, CALCIUM AND TRANSMURAL Rothwell, K. and Whitehead, J. K. STIMULATION; WITH A SPECIAL REFERENCE METHODS, APPARATUS: NEW PRODUCT RE.,:y"tRCH, TO THE CATECHOLAMINE RELEASE. Kobe PROCESS DEVELOPMENT AND DESIGN.Chem.9ry Journal of Medical Sciences 15(27771- and Industry (45):1628-30, Nov 8,-In97 1767-7unl-91,97"

A 12758 A 12731 Barlow, R. B., Thompson, G. M., and Scott, Halfpenny, P. F. and Starrett, P. S. N. C. CONTROL OF ODCE AND IRRITATION DUE TO THE AFFINITY AND ACTIVITY OF COMPOUNDS CIGARETTE SMOKING ABOARD AIRCRAIPT. RELATED TO NICOTINE ON THE RECTUS ASHRAE Journal 3(3):39 -44, Mar 1961. ABOOMINIS MUSCLE OF THE FROG (RANA PIPIENS). British Journal of DEITinacologrraTT:555-84, Rciv 1969. A 12734 Gaitan, E. NORMAL AND ABNCEMAL VASOIRESSIN A 12761 ACTIVITY IN MAN. In: Progress in Burdman, D., Garret, M., and Benninghoff, Endocrinolog/, Excerpta Medics. Inter- D. L. national Congress -eries, No. 1e4, 1969, COMPARATIVE CYTOMORPHOLOGY OF IRRADIATION pp. 249-57. ATYPIA AND CHEMICALLY INDUCED CARCINOMA IN THE MOUSE CERVIX.Acta Cytologica 13(11) :620-33, Nov 19677-- A 12737 Schneider, F. H. SECRETION FROM THE CORTEX-FREE BOVINE A 12763 ADRENAL MEDULLA, British Journal of Crowe, M. Pharmacology 37(2)77179. Oct 1369. SKELETAL ANOMALIES IN PIGS ASSOCIATED WITH TOBACCO. Modern VeterInnry Practice 50(13)154 .757 arIMPA-7- A 12739 Brown, D. A., Halliwell, J. V., and Scholfie'd, C. N. NICOTINE UPTAKE BY ISOLATED RAT GANGLIA. British Journal of Pharmacology 37(2): 510P- 511p7-Oct' r9.

89 93 A 12764 A 12811 (continued) Legg, P. D., Chaplin, J. F., and Collins, Czeizel & Czeizel-designed "smoking G. B. apparatus" ecApped with adeate record- INHERITANCE OF PERCENT TOTAL ALKALOIDS ing facilitiea.The simulated smoking IN NICOTIANA TABACUM L. Populations De- was imposed eight times daily for 15 riviiiMBEitrTtragFf Low Alkaloid Lines minutes. The results were compared with Burley and Flue-cured Varieties. against four control animals of identical Journal of Heredity 50(4):213-7, Jul-Aug age, genealogy and weight. The frequency 1969. of the differential spermatogenetic phases were determined according to Roosen- Runge and by the Giesel techniques. In- A 12794 hibition measurements on the spermato- Coleman, H. N., Sonnenblick, E. H., and cytes were determined by a progressively Breunwald, E. calibrated scale comprising 9 divisional MECHANISM OF THE NOREPINEPHRINE-INDUCED phases. The clear-cut spectrum reflects STIMULATION OF MYOCARDIAL OXYGEN CON- the qualitative interference in the SUMPTION AS STUDIED IN THE ISOLATED division of spermatocytes. Tha ultimate CAT PAPILLARY MUSCLE.Abstract of category, i.e. Number IX-Phase, was paper presented at the American Heart Labeled as the degenerative tubular stage. Association, 40th Scientific Sessions The pathologic degradation of teaticlas is and 21st Annual Meeting, Council on illustrated by 7 photo biopsies. Arteriosclerosis, San Francisco, California, Oct 18-19, 1969, Circulation 36(4, Suppl 2):II-69, Oct 1967. A 12815 Zasypka, A. T. IWITCEPCCEMILE ViTASONTWIRTIT001-A. A 12793 Kershbaum, A., Osada, H., Scriabine, A., KANTSEROGENNYYE METABOLITY TRIPTOFANA. Bellet, S., and Pappajohn, D. 3. (CARCINOGLNIC METABOLITES OF TRYPTOPHAN.) INFLUENCE OF NICOTINE ON THE MOBILIZATION Voprosy Onkolog1115(7):108-18, Jul 1969, OF FREE FATTY ACIDS FROM RAT %0IPOSE Russian767.-T.-- TISSUE IN VITRO AND IN THE ISOLATED PERFUSEL7bUTTIMB. Absteact of paper A review is made of experimental work presented at the American Heart reported in the literature on the induce- Association 40th Scientific Sessions ment of urinary bladder tumors by and 21st Annual Meeting, Council on tryptophan and its metabolites. Arteriosclerosis, San Francisco, Cali- fornia, Oct 18-19, 1967, Circulation 36(4, Suppl 2):11-20, Oct 1967. A 12817 Turuaov, V. S. r1P061EME KOKAITCEMID-C3A. A 12798 Kershbaum, A,, Kuzuya, F., Hirabayashi, M., K PROBLEME KOKANTSEROGENEZA. (ON THE Pappajohn, D. J., and Eellot S. PROBLEM OF 00CARCINO3ENESIS Voros . 1) EFFECT OF CIGARETTE SMOKING ON POST- Onkologil 15(6):108-15,Jun 96 , HEPARIN CLEARING FACTOR ;LIPOPROTEIN Russian LAbs.) LIPASE). Abstract of paper presented at the National Meeting of the American In this review of the literature on Federation for Clinical Research, the mechanism of cocarcinogenesia, Atlantic City, New Jersey, May 4-5, mention ie made of experimental work on 1968. Clinical Research 16(21:346, the combined effect of radiation and Apr 19687 3,4-benzopyrene on the skin.

A 12811 A 12818 Viczian, K. and Helniach, P. Tashbekov, B. U., Postupaliskiy, Ya. N., A DORANYZAS HATASA A SPERMATOGENESISRE. Davydov, Ye. S., and Bolotova, M. N. (THE EFFECT OF SMOKING ON SPERMATO- 0 COMP3/49494 3,4-bE13f tilhA M ATTAX4,EPHOM GENESIS.)Magyar Noorvosok Lapp, 30(5): K034001 FEKOTOR-UKX IFC40XXYWKIX.TAM X 412-8, Sep 1967, HurigEFTER(KEITT. XEDVE MDIATCU. Animal studies with simulated effects 0 SODERZHNII 3,4-BENZP1RENA V ATMOSFERNOM of smoking were performed to elucidate the VOZDUKHE NEKOTORNYKH GORODOV UZBEKISTANA V detrimental interference on the mechanism LE7NIE MECYATSY. (3,4-BENZOPYRENE CONTENT of spermatogenesis. The experiments were OF THE AIR IN SOME CITIES IN UZBEKISTAN IN performed on 16 male rats of known genetl- THE SUMMER MONTHS.)Meditsinskii Zhurnal ogy, weighing between 160 to 200 g. The Uzbekistan& (7):46-49, July 1969, hrrirrerK animals were confined for 6 weeks in the IA158./

90 94 A 12818 (continued) A 12824 (continued) 250 g) were given 700 micrograms of DMBA- Results are given of the determina- 12 C14 and were sacrificed 48 hours later. tion of 3,4-benzopyrene in samples of air The organs removed (the liver, kidneys, in 5 industrial cities in Uzbekistan in lungs, and spleen) were homogenized, and the sumanr of 1968. The samples were the DNA was extracted, analyzed, and taken at a distance of 1.5 m. from the chromatographed, after which radio- ground (equivalent to man's respiration activity levels were determined.The zone) in residential, industrial and quantity of DMBA (pmol/mg DNA) bound to mixed residential-industrial areas. 3,4- the DNA was 3.15 in the liver, 1.94 in benzopyrene was detected in all samples the kidney, 0.98 in the lungs, and 3.82 and ranged from 0.032 microg./100 cu. m. in the spleen. These data demonstrate in zones of minimal pollution to 3.26 that DMBA is bound to the DNA of various microg./100 cu. m. in heavily polluted organs with a stable link. The implica- zones. tions of such a link with regard to the increased probability of neoplaetic transformation in body tissues are cited. A 22822 Beritic, D. TOKSICKA I KANCERIGENA SVOJSTVA NITROZAMINA. A 12826 (TOXICITY AND CARCINOGENIC PROPERTIES OF Murata, H. NITROSAAINE.) Arhiv za Higijenu Rada JIKKEN KOTSUSHUYO NO RUIDAI ISHOKU NI iTokeikologiju7277O-2, 1969, TSUITE. (TRANSPLANTATICN OF EXPERIMENTAL NMroatian (Abs. BONE TUMORS IN SUCCESSIVE GENERATIONS OF RATS.)Ntchidai Ipku gasshi 28(8): Although it has been known for about 835-54, Aug 1969, Japanese-7E7M 15 years that dimethylnitrosamine is a rather toxic substance, it has only The carcinogens, 3,4-benzopyrene, recently been discovered that it has 20-methylcholanthrene, and 4- carcinogenic properties. Further studies nitroquinoline-N-oxide, were administered revealed that diethylnitrosamine also has in quantities of 1 and 6 mg, via intra- carcinogenic properties and that, in medullary injection into the tibia, to general, all rltrosamines are not only infant male Wistar :late. Bone tumors, toxic but also carcinogenic. Nitrosamines chiefly fibrosarcomae, developed in 33 are readily formed whenever oxides of cases, and were successfully transplanted nitrogeas react with amines as, for into the intramedullary cavity of the example, while smoking tobacco and during tibia and the subcutaneous tissue of the the smokehouse treatment of meats.While back for several successive generatioaa. an in-depth study of the problem has not been reported, it can be speculated thr.t esophagus cancer in smokers is caused by A 12827 these agents, since nitrosamines easily Kurihara, T. reach the esophagus in amounts and con- KAKVSHU KAGAKUTEKI HATSUGAN BUSSHITSU centrations sufficient to induce the NI YORU JIKKEN KOTEUSHUY0 NO SEISEI formation of malignant neop)asms.Not- NI TSUITE. (ON THEINDUCEMENTOF withatending numerical value disagreement EXPERIMENTAL BONE TUMORS BY VARIOUS among the various authors, it appears to CHEMICAL CARCINOGENS.)Nichidai be certain that a concentration of 5 parts 'Baku Zasshi 28(9):921-41, Sep 1969, per million in swallowed saliva is able to Japanese e.) produce a carcinogenic action. The carcinogens, 3,4-benzopyrene, 20- methylcholanthrene, and 4-nitroquinoline- A 12824 N-oxide, were administered in quantities Prodi, O., Finzi, C., and Francheechi, C. of 1 mg and 6 mg, via intramedullary LEGAMT DEL 7,12-DIMETI18ENZ(a)ANTRACENE injection into the tibia, to infant AL DNA DI DIVERSI ORGANI NECRATTO. male Wistar Rats. Bone tumors developed (THE LINK BETWEEN 7,12-DIMETHYLBENz(a)- in 23 percent of the rats receiving ANTHRACEN6 TO THE DNA IN VARIOUS ORGXNS 1 mg of 3,4-benzopyrene and in 29 percent OF THE RAT.) Bollettino della Societe of those receiving 6 mg. Of the rats Italian di Bloloiri.5,;FriirElamri---- receiving 6 mg of 20-methylcholanthrene, 4511)' -9; JIM 15, lgtr,Ttriari (Abs.) 38 percent developed bone tumors. In the case of 4-nitroquinoline-N-oxide, Tho investigation reported here was bone tumors developed in 9 percent of the initiated for purposes of verifying the rats receiving 1 mg, and in 31 percent interaction bet...ten 7,12-dimethylbane(0_ orthose receiving 6 mg.The average anthracene (DMBA) and LVA in the rat time before development of the tumors given intraperitoneal hydrocarbon injec- ranged from 20 to 54 weeks. Detailed tions. Female Wistar Rats (body weight X-ray and histological findings are given.

91 A 12828 A 1283? Krick, E. Borisyuk, Yu. P. CHEMISCHE CARCINWENESE VAN AROMATISCHE o6/ACTON:NIP-KU AKTIMHOCTilnsmwrolac KYPHItA. AMINEN: REACTIEVE METABOLIETTN EN HUN INTERACTIE ME r MACROMOLECULEN IN DE CEL. 0 BLASTOMOGENNOY AKTIVNOSTI PRODUKTOV (AROMATIC AMINE CARCINOGENESIS: REACTIVE KURENIYA. (ON THE BLASTOMOGENIC METABOLITES AND THEIR INTERACTION WITH ACTIVITY OF THE PRODUCTS OF SMOKING.) MACROMOLECULES IN THE CELL.) Jaarboek Voproay Eksperimentalinoi Gnkologii Kankeronderzoek en Kankerbeatrijding 111:47-55, 1968, Russian (Abs.) 17T2MS7rinr; Latch (Abs.) Tcbacco tar, from the smoke of Metabolic activation is a prerequisite °Pamir" brand of cigarettes was divided for the observed binding in vivo of the into 2 fractions, one containing the carcinogen AAF and its deFiVirffes with polycyclic hydrocarbons, including ribosomal RNA and DNA.Two reactions are 3,4-benzopyrene, and the other, the reaporaible for this metabolic process: residue after removal of the polycyclic the first, N-oxidation, to catalyzed by hydrocarbons. The tar fr ;ions were enzymes present in the microsomes of the tested on the skins of 2-month-old liver. A second activation reaction of purebred white, male mice. The results N-hydroxy-AAF is essential for the binding showed that tobacco tar, especially to tissue receptor molecules, since N- that produced by the extraction of the hydroxy-AAF does not react non-enzymasical- smoke with benzol has blastomogenic ly with nucleic acids and proteins in vitro. activity with respect to mouse skin. Recent experimental results suggest-that-1E Most blastomogenic activity was shown the second step a sulfate ester of N- by the fraction containing the polycyclic hydroxy-AAF is formed with the participa- hydrocarbons. Tobacco tar, deprived of tion of a sulfokinase dependent on Mg2+ the polycyclic components merely has and ATP.The ester AAF-N-SO4Na is cocarcinogenic prc werties, stimulating chemically highly reactive and can be the action of the carcinogenic hydro- expected to react rapidly in the environ- carbons. Increasing the content of 3,4- ment of its formation. Direct effects benzopyrene of tobacco tar increases its following administration of AAF or AF blastomogenic activity. The blastomo- to rats are structural damage to the genic effect of products or smoking de- endoplasmic reticulum, changes in activity pends on the union of carcinogenic hydro- of the drug-metabolizing enzymes and carbons of the 3,4-benzopyrene type and alterations in anabolic functions of the cocarcinogenic factors activating their ribosomal, which are affected by effect. corticosteroid hormones. (Author Abstract)

See alsoC 10219, C 10291, C 10606, rit606, C 10618, C 10855, F I0611

92 96 SECTION R. MORTALITY AND MORBIDITY

B 10212 B 10316 (continued) Hammond, E. C. LARYNGEAL CARCINOMA IN THE LUBLIN AREA.) QUANTITATIVE RELATIONSHIP BETWEEN Otolaryn&ologil Polska 22(5):671-7, 1968, CIGARETTE SMOKING AND DEATH RATES. Polish tkba.j-- In Wynder, E. L. and Hoffmann, D. (Editors). Towa--, A Less Harmful Ssudies were performed on the morbid- Cigarette. U. Department of Health, ity from laryngeal carcinoma in the pop- Education, and Welfare, Public Health ulation of Lublin in the rears 1960-1965. Service, National Cancer Institute Indices of morbidity were elaborated for Monograph No. 28, Jun 1968, pp. 3-8. individual years for the populations of various regions and for both sexes and for consecutive age groups of 5 years. B 10242 The results of these observations were Pharmaceutical Journal. compared with analogous indices elabor- PUBLIC HEALTH REPORT FOR ENGLAND AND WALES ated on the basis of report cards of FOR 1967. Pharmaceutical Journal 201 malignant neoplasms. (5478):441, Oct 26, 1968.

B 10365 B 10249 ManJfacturirg Chemist and Aerosol News. Medical World News. THE EFFECTS OF SMOKING. Manufacturing A BEDTIME STORY ABOUT STROKES. Chemist And Aerosol News 39(12):2, Dec VA=Medical World News 9(46):72, Dec 15, T76.37-- B 10375 B 10232 Brownlee, K. A. Review of Allergy. A REVIEW OF "SMOKING AND HEALTH.' TOBACCO SMOKE: TELLINO IT LIKE IT IS. Journal of the American Statistical (EDITORIAL)Review of Allergy 22(11): AllicTerEti7xriT2271317737p1965. 1025 -6, Nov 19117--

B 10406 B 10267 Rakover, J. and Kellner, G. Connecticut Medicine. CAN THE DEVIATING LUNG-CANCER- AIR POLLUTION: 1. THE PROBLEM. SMOKING RELATIONSHIP IN ISRAEL BE Connecticut Medicine 32(11)1799-801, EXPLAINED BY DIFFERENT DISTRIBUTION Nov 1968. PATTERNS OF HISTOLOGICAL TYPES?In Kellner, G., Cancer Mortality and Morbidity in Israel: 1950-1961, Part B 10270 Geneva, World Health Organization, Cancer West Virginia Medical Journal. 66.68, 1967, pp. 45-57. THE TOBACCO HAZARD.West Vir inia Medical Journal 64(12r14, ec 968. B 10415 Koszarowski, T., Gadomska, H., and B Drozdzewska, Z. ACS Cancer News. ZACHOROWANIA I ZUONY NA NOWOTWORY MALE LUNG CANCER RATE UP SHARPLY. ZLOSLIWE W POLSCE W LATACH 1961-1964. ACS Cancer News 22(2)119, Fall- (MORBIDITY AND MORTALITY DUE TO griterrrir87 MALIGNANT NEOPLASMS IN POLAND IN 1961-1964.) Polskie Archlwum Medycinz:Wewnfrp 41(2)120E-13, B 1CC95 19E84Poi DIE a. Lancet. DEATHS FROM LUNG CANCER AND ROO ACCIDENTS. Investigations in selected areas Lancet 2(7577)11088, Nov 16, 1968. have shown that the incidence of malignant neopleatic disease in Poland may be estimated at about 57,000 new B 10316 cases every year. Neoplaatic incidence Klonowski, S., Semczuk, B., Peszynski, J., in women amounts to almost 60 percent and Zderkiewicz, H. of all neoplasms reported. In most ZACHCROWALNOSC NA RAKA 1G1TANI W cases they concern the uterine cervix, REG:CNIE LUBELSKIM. (MORBIDITY FROM breast, and bile ducts. In men most frequent are neoplasms of stomach,

93 97 B 10415 (continued) B 10496 lungs, and skin. Neoplasms occurring Tcbacco. in towns are more frequently reported PURE BIOLOGICAL EVIDENCE POINTING than those occurring in the country. AWAY FROM SMOKING-DISEASE LINK, SAYS The percent of histologic confirma- DR. C. C. LITTLE.Tobacco 168(7):13, tion amounts to 50. Mortality rate Feb 14, 1969. from neoplastic diseases is higher in men than in women.The most frequent, causes of death from neoplastio B 10515 disease are stomach and Sung cancer in Weir, J. M. men, and neoplasms of stomach and bile SMOKING'S EFFECTS ON THE ORAL TISSUES- - ducts in women. (Author Abstract) EPIDEMIOLOGICAL DATA, EDUCATIONAL RESPONSES. Presented at Dental Health Section, American Public Health B 10450 Association Annual Meeting, Detroit, Teeling-Smith, G. Mich., Nov 11, 1968, 19 PP. LIABILITIES. Public Health 83(1): 17-42, Nov 196r---- B 10546 Concours Medical. 10465 CIGARETTE, CANCER DU POUMON ET von Essen, C. F., Shedd, D. P., THROMBOSE CORONARIENNE.Une Connelly, R. R., and Eisenberg, H. Enquete Anglaise Sur 54,460 Ouvriers CANCER OF THE LARYNX IN CONNECTICUT, de l'Industrie. (CIGARETTES, 1935-1959. Cancer 22(6):1315 -22, LUNG CANCER AND CORONARY THROMBOSIS. Dec 1968. An English Investigation of 54,460 Industrial Workers.) Concours Medical 90(40i:6304, 6307, Oct 5, B 10485 196.8, French Abs.) de Groot, M. J. W. RECENTE TRENDS IN DE KANKERSTERFIE A 3-year study of men, 40 years BIJ MANNEN EN VROUWEN. (RECENT of age and older, in 119 establish- TRENDS IN CANCER MORTALITY IN MN ments in Greater London has been AND WOMEN.)Tildschrift voor Sooiale reported. Slightly more than 10 Geneeskunde 46(251782 ;-7,77X 15, 1968. percent were heavy smokers (25 Dutch TAba.) cigarettes + daily); light and average smokers were about equal in Age standardized cancer mortality numbers. The mortality rate the to increased for men from 167.0.in 1955/ lung cancer was 4 times greater in 1957 to 197.5 per 100,000 in 1964/ smokers than in nonsmokers. The 1966. In women no increase was mortality rate in smokers increased found. Table 4 shows the age specific with the number of cigarettes smoked rates. The overall increase in men daily, with a correspondingly higher appeared to be due to respiratory rate in the above SO age groups. cancers. This primary si,a accounted Heavy smokers who kept cigarettes in in 1955 for one in five deaths by the mouth between puffs had a still cancer. In 1966--only 12 years later- - greater mortality rate, 14 times as this ratio was one in three. The male great as in nonsmokers.Heavy smokers crude death rate for 'lung cancer' had a 3 times greater risk of dying increased in this period by 88 percent. from coronary thrombosis than nonsmokers; (Author Abstract) the risks for smokers of all categories was twice as great as for nonsmokers. For cancers other than lung cancers, B 10494 one could observe the unfavorable Sterling, T. D. influence of cigarette smoking only in AN EVALUATION AloD CRITIQUE OF THE the older age groups. The mortality REPORT LINKING CIGARETTE SMOKING TO rate from other causes was to relation GENERAL MORBIDITY AND DISABILITY. to age and not to smoking. Washington University, Department of Applied Mathematics, St. Louis, Mo., n. d., 74 pp. B 10557 Gifford, J. H. THE MENACE OF SMOKING. Review of B 10495 Allergy 22(12):1110-1, DiFE-1168. Pennsylvania Medicine. 'SMOKING AND HEALTH WEEK.' Pennsylvania Medicine 72(2)18, Feb 1969.

94 98 IS 10624 B 10576 Denk, W., Hansluwka, H., and Karrer, K. Simon, J. L. ZUR EPIDEMIOLOGIE DES CARCINOMS I. THE HEALTH ECONOMICS OF CIGARETTE MITTEILUNG.DIE ENTWICK1UNG DER CONSUMPTION. Journal of Human KREBSSTERBLICHKEIT IN OSTERREICH. (THE Resources 3(1)1111=7, WIA177968. EPIDEMIOLOGY OF CARCINOMA. I. THE GROWTH OF CANCER MORTALITY IN AUSTRIA.) Zeitechrift fur Krebsforachun 65:488-505, 9 10601 1963,Germanrrbs. Slack, J. and Evans, K. A. THE INCREASED RISK OF DEATH FROM Statistical studies of the cancer ISCHAEMIC HEART DISEASE IN FIRST DEGREE mortality of Austria in the last 40 years RELATIVES OF 121 MEN AND 96 WOMEN WITH indicated a progressive increase in the ISCHAEMIC HEART DISEASE. Journal of number of deaths due to malignant neo- Medical Genetics 3:239-57, 19667 plasms. In men the mortality increased at 55 years of age, in women at the 70th year. The composition of the age group B 10613 and the measure of diagnostic accuracy Florida Health Notes. were decisive for the increase. With re- CIGARETTES AND LUNG CANCER.Florida spect to these factors, the cancer mortal- Health Notes 61(2):37-8, Feb T5t9. ity in Austria, when compared with other larger countries, was not so different as it seemed from the crude figures. There 10616 has been a genuine increase in carcinoma Miller, I. of the respiratory organs, especially in CURRENT STATUS OF EPIDEMIOLOGICAL men, whereas gastric carcinoma had de- STUDIES ON SMOKING AND HEALTH. creased. (Author Abstract) Presented at the 1966 Joint Statistical Meetings, Pittsburgh, Pa., Aug 21, 1968, 10 pp. B 10687 Journal of the American Medical Association. B 10623 CANCER or THE LUNG ON THE INCREASE. Denk, W., Hansluwka, H., and Karrer, K. Journal of the American Medical ZUR EPIDEMIOLOGIE DES CARCINOMS. II. marem-ro/rmilminirro, MITTEILUNG DIE KREBSSTERBLICHKEIT IN DEN OSTERREICHISCHEN BUNDESLANDERN. (THE EPIDEMIOLOGY OF CARCINOMA. II. THE MORTALITY OF CANCER IN THE AUSTRIAN B 10688 FEDERAL STATES.)Zeitschrift fur Kurohara, S. S. Krebsforschung 66:22549, 19647derman THE FORCES OF MORTALITY IN BLADDER (Abs.) CARCINOMA. Journal of the American Medical AssonEriFFMTEM!TST:77 The differences in the cancer mortal- reirrer;1959. ity among the Austrian Federal States in the years 1939/41, 1962/54and 1959/61 were analyzed. The variations in the B 10742 level of health care of the population Chicago Medicine. prejudice these differences considerably. INFLUENZA AND THE AFTERMATH. (Editorial) Consequently, it becomes difficult to Chicago Medicine 72(3) 83, Feb 1, 1969. elucidate the important epidemiological questions regarding the existence of real regional differences and the developmen- B 10760 tal tendencies occurring with time. An Kastelan, S. estimation of the most obvious distortions SMRTNOST OD MALIGNIH NEOPLASM U MAW leads to an approximation of the differ- SPLITU U DESETMDISNIEM RAZDOBLJU (1957- ences, whereby women statistically mani- 1966). ( MORTALITY FROM MALIGNANT NEO- fest no significant differentiation. PLASMS IN THE TOWN OF RPLIT IN THE PERIOD With men, however, important factors (1957-1966).) Lilecnicki yleanik 90(10): suggest a truls excessive mortality in 919-27, Oct 1961, Sergo -cra-VIE(Abs.) Vienna which expresses itself in the entire mortality. A tendency for the The author sets forth mortality values between Vienna and the remaining trends of malignant neoplasms in Split Federal States to equilibrate seems like- during the 1957-1966 period. The ly. The counterpart of this tendency is specific death rates are given in fond in the development of the entire relation to sex, age, and localization. mortality. (Author Abstract) Proportional mortality rates are given

9S B 10760 ( continued) B 10843 (continued) as well.The tendency towards increasing followed to learn whether the hypotheses cancer mortality ie evident. Some differ- stand up in the application of statistics ences, in relation to literature data, in modern epidemiological research. are observed in the frequency of certain The individual steps consisted of the localizations. (Author Abstract) formulation of the question (Does nicotine act upon humane?) and its analysis, formation of comparison B 10791 groups, critical evaluation of the data, British Medical Journal. organization and description of the data, SCOTLAND IN 1967.British Medical testing the hypotheees, and interpreta- Journal 4(5634)1859=n7M-2171,18. tion of the results.The authors concluded that present-day epidemiological research does not fulfill all B 10816 requirements for statistical evaluation National Institute of Health. and that statistical probability test CANCER OF RESPIRATORY SYSTEM.U. S. methods should be introduced before Department of Health, Education, and generalizations concerning the results Welfare, Public Health Service, of prospective studies could be made. A National Institute of Health Publica- brief lexicon of the etatistlaal concepts tion No. 30, 1968, pp. 75-90. is attached.

73 nal B 10844 Journal of the Indiana State Medical Gaell, 0., Immich, H., and Strobel, M. Association. TABAKRAUCHEN UND MORTALITAT. (TOBACCO CIGARETTE MANUFACTURER LIABLE FOR SMOKING AND MORTALITY.) Inn Schlevel- CANCER DEATH. Journal of the Indiana bein, H. (Editor). Nikotin: Pharmakologie State Medical ArsisTarliiag2TITTg7=37 and Toxikologie des Tabakrauches. an E7T9g17---- Stuttgart (West Germany), Georg Thieme Verlag, 1968, pp. 120 -53., German (Abs.)

B 10827 Various statistical-epidemiological Medical Officer. investigations were reviewed: Influence CIGARETTE SMOKING (TIME LOS FROM of smoking on general mortality; mortality WORK.) Medical Officer 120(22)1 in relationship to the type of tobacco 522, Nov-0717637----- products, smoking intensity, inhalation of cigaretlAt smoke, length of cigarette butt and age and duration of the smok- B 10828 ing habit) mortality after reduction in Public Health Statistics, Department of smoking intensity; influence of location Health, Pa. (urban and rural); personality and NATALITY & MORTALITY STATISTICS 1968. constitution; relationship between smok- Commonwealth of Pennsylvania Department ing and individual causes of death) of Health, Bureau of Administration, critical considerations on the Public Health Statistics 18(2):1-11, statistical- epidemiological investiga- Jan-Jun 1968. tions; and methodological problems. A section of the report was entitled 'Remarks on the Terry Report (Smoking B lous and Health, 1964) and the 'Health Immich, H. Consequences of Smoking (1967)'. EINFUHRUNG la Dig STATISTrK LINTER BESONDERER BERUOKSIGHTIOUNG DER EPIDEMIOLOOIE. (SHORT INTRO- B 10873 DUCTION TO STATISTICS WITH SPECIAL Saylor, L. F. CONSIDERATION TO EPIDEMIOLOGY.) In: CANCER IN CALIFORNIA--NEW DEVELOPMENTS. Schievelbein, H. (Editor). Nikotin: California Medicine 110(2)1197-8, Pharsakologie ond Toxikologie des Peb 1969. Tabakrauches. Stuttgart (West Germany), Georg Thicme Verlag, 1968, pp. 99-119., German (Abe.) B 10915 Anchev, N., Popov, I., Monov, N., and Epidemiological investigations Ouzounov, K. were deemed necessary to study the SPREADING OF MALIGNANT NEOPLASMS IN THE effect of tobacco smoke on the human PECKE'S REPUBLIC OF BULGARIA. Neoplasms organism. The authors outlined the 15(5J:01-68, 1968. statistical procedure which has been

966 /610 B 10927 B 11043 Heroic', H. J. and Berndt, H. (continued) CANCER INCIDENCE IN THE GERMAN DEMOCRATIC the Canary Islands, and other distant lands. In keeping with such worldwide REPUBLIC. SELECTED TABLES. Neoplasms 15(5):517-22, 1968. interest, the present journal (Przeglad Lekarski) also provides brief medical opinion on the problem of intoxication B 10954 associated with tobacco and some of its Sen, M. ingredients such as nicotine. Original TWELFTH ANNUAL CONFERENCE PRESIDENTIAL articles of prominent workers inthis ADDRESS. field are also published from timeto Indian JOurnal of Public time. Health 12(27774.7647117-17613. In Poland, the Polish Medical Association as early as 1881recognized the deleterious effect on humansdue to B 10973 tobacco :smoking. Hennessy, E. PERFORATED PEPTIC ULCER: MORTALITY B 21074 AND MORBIDITY IN 603 CASES. Australian Royal Society of Health Journal. and New Zealand Journal of Surgery 317317745-52, Feb 1969. SMOKING STATISTICS.Apyel Societ of Health Journal 89(ITTCH, an. IVTIVI7 B 10988 Cowan, G. A. B. and Holmes, F. F. B 11112 COMPUTERS AND CANCER. Journal of the Kansas Medical Society 70(3):977657- Journal of the American Medical Association. W-TY6f7----- CIRRHOSIS OP THE LIVER ON THE INCREASE. Journal of the American Medical Associa- tion 207M1721124 Mar 17,1969. B 10999 Kato, Y., Ferguson, T. B., Bennett, B 11133 D. E., and Burford, T. H. Markush, R. E. OAT CELL CARCINOMA OF THE LUNG.Cancer 23(3):517-24, Mar 1969. NATIONAL CHRONIC RESPIRATORY DISEASE MORTALITY STUDY. II. Mortality Associated with Persistent Cough and B 11017 Phlegm in the United States, 1963. Jussawalla, D. J., Naenszel, W., Journal of Chronic Diseases 21(11 -12). Deahpande, V. A., and Natekar, M. V. 737-48, Apr 1969. CANCER INCIDENCE IN GREATER BOMB4Y: ASSESSMENT OF THE CANCER RISK BYAGE. B 11144 British Journal of Cancer 22(4):623-36, Dec 1968. Public Health Reports. NYC AIR POLLUTION AFFECTS MORTALITY. Public Health Reports 64(3):283, Mex.1969. B 11022 Muir, C. S., Evans, M. D. E., andRoche, P. J. L. B 11145 Publi^ Health Reports. CANCER IN SABAH (BORNEO). A Preliminary Survey. British Journal of Cancer 22(4): RATES DIFFER BY RELIOIONS IN um CANCER 637-45, DFF-Pqr8. MORTALITY. Public Health Reports 84(3): 226-7, Mar 1969.

811043 Giedosz, B. B 11146 Public Health Reports. SLOWO WSTEPNE. (INTRODUCTION) Prze lad Lekarski 24(6):509-10, 1968, Polies CIRRHOSIS DEATHS INCREASE AMONG 25-TO Ws.) 44-YEAR-OLDS. Public Health Reports 84(3)1263-4, Mar 169. The ro'e of the physician has changed on s worldwide scale in recent years. 8 1114 7 Now he r-,) longer merely cures distases, Skinner, E. F. but also prevents them, and isconcerned over disease-causing agents resulting SMOKING AND LUNG CANCER. Medical Trial Technique Quarterly 15(3)159-61, Mar from meteorological conditions. Reports on the effects of "civilizing" tobacco 196T. smoking have been published in Kenya,

97 /Of B 11155 B 11273 (continued) Gadomska, H., Koszarowski, T., and mortality of cancer shows a signifi- Drozdzewska, Z. cant decrease of 25 percent for INCIDENCE OF MALIGNANT NEOPLASMS OF women but only 10 percent for men. THE STOMACH IN POLAND AND THE CITY A continuous decline is seen in OF WARSAW -- MORTALITY FROM NEOPLASMS mortality from tumors of the stomach, IN POLAND IN TICE YEARS 1962--1964. and to some extent from carcinoma of Acta Mediae Po/ona 9(4)1359-63, the oesophagus and uterus. A significant increase is noted in lung cancer of men, totalling now 24 times the mortality in 1910. Lung cancer B 11234 le the most frequent neoplasm since Harewood, J. and Heath, K. 1960. Mortality from carcinoma of RECENT TRENDS IN INFECTIOUS AND DEGENERA- the prostate and pancreas have also TIVE DISEASES AS CAUSES OF DEATH IN increased.High mortality quotients IRLNIDAD AND TOBAGO. Caribbean Medical of over 2.0 in men as compared to 1.0 Journal 29(1 -4)179-69, 771:77--- in women are found for cancers of the respiratory tract (oral cavity to bronchus), oesophagus and urinary B 11242 bladder, suggesting an etiologic Conroy, J. P. relationship to smoking.Women exhib- SMOKING AND THE ANESTHETIC RISK. it markedly higher mortality from Anesthesia and Analgesia 46(3): cancer of the gallbladder and thyroid 331r4113trrgaP7un Ivo . gland than do men. The changes in cancer mortality for age and sex are presented in detail for the period B 11243 from 1952-1965. (Author Abstract) Ramdial, S. and Poon-King, T. MYOCARDIAL INFARCTION: A TWO-YEAR STUDY AT THE SAN FERNANDO HOSPITAL. 8 11299 Weat Indian Medical Journal Cederlof, R,, Friberg, L., and Hrubec, Z. iT(Z):253, CARDIOVASCULAR AND RESPIRATORY SYMPTOMS .711 RELATION TO TOBACCO SMOKING.Archives of Environmental Health 16(6):934'477 B 11244 Win 1969. British Medical Journal. MORTALITY IN ENGLAND AND WALES IN 1967. British Medical B 11300 Journal 1(b644):g5g71 R576, 1969. Lemon, P. R. and Kuzma, J. W. A BIOLOGIC COST OF SMOKING,Archives of Enviro Health 18t6):950-5, B 11269 Mh---TV137nmontal Mancuso, T. F. and Mordell, J. S. PROPOSED INITIAL STUDIES OF THE RELATIONSHIP OF COMMUNITY AIR POLLU- B 11306 TION TO HEALTH. Environmental Medical Officer. Research 2(2):102-33, Feb 1969. STILLBIRTHS AND INFANT MORTALITY. Medical Officer 121(9).116 -7, Feb 28,

B 11273 °sell, 0. TREND DER CARCINOMSTERBLICHKEIT DER B 11307 LETZTEN 50--60 JAHRE, DAROESTELLT Metropolitan Life Insurance Company AM BEIPIEL DER SCHWEIZ. (THE Statistical Bulletin. TREND OF CANCER MORTALITY IN THE LAST CANCER SURVIVAL AMONG MEN IN RECENT 60 YEARS DEMONSTRATED IN THE CANCER YEARS. Metropolitan Life Insurance EPIDEMIOLOGY OF SWITZERLAND.) Company natiatical brilnitin 501 Zeitschrift fur Krebtforschung 72(2)1 2-4, Ye%) 1969. 197=210, 19657-bernan (Abs./

Tho development of cancer tar- B 1)312 tality in Switzerland during the Anderson, T. W., Le Riche, W. H., and period from 1910-1967 is analyzed MacKay, J. S. using age connected and raw sIAtistics. SUDDEN DEATH AND ISCHEMIC HEART DISEASE. The trend of the age standardized New England Journal of Medicine 280(15)1 FOF-T7M-1671PRIT.--

98 /o2, B 11313 B 11375 (continued) Journal of the Indian Medical Association. to minimize the damages caused to the CIGARETTES CAUSE RISK OF STILLBIRTH. community by precocious disability. It Journal of the Indian Medical is also wished for the future a different ATTaTatiFh757(27T917 7o-1171969. order of "pensioning off" problem, based on the conception of "protected work". (Author Abstract) B 11318 Indian Medical Journal. 150 AMERICANS KILLED DAILY By CANCER. B 71383 Indian Medical Journal 62(11):252, Medical Services Journal, Canada. Nov LUNG CANCER AND OTHER SMOKING DISEASES CONTINUE TO INCREASE.Medical Services Journal, Canada 23(10:1551-2, Dec rfri. B 11334 Stukonis, M. and Doll, R. GASTRIC CANCER IN MAN AND PHYSICAL B 11394 ACTIVITY AT WORK. International Watson, W. L. Journal of Cancer 412):248-54, Mar 1969. MEMORIAL HOSPITAL LUNG CANCER ABSTRACT FORM. In: Watson, W. L., (Editor). Lung Cancer: A Study of Five Thousand B 11368 Memorial Hospital Cases. Saint Louis, Spigliati, P., De Grandis, C., Busatti, L., Mo., The C. V. Mosby Company, 1968, and Conti, E. pp. 555-45. SULLA INCIDENZA DELLE VARIE AFFEZIONI MORBOSE NELLA PATOLOGIA DEL SOGGETTO ANZIANO. RILIEVI E CCNSIDERAZIONI SU B 11407 UNA CASISTICA OSPEDALIERA. (INCIDENCE Cameron, P., Koetin, J. S., Zaks, J. M., OF VARIOUS DISEASES IN THE PATHOLOGY OF Wolfe, J. H., Tighe, G., Oselett, B., OLD PATIENTS. REMARKS AND CONSIDERATIONS Stocker, R., and Winton, J. ON CASUISTICS OF A HOSPITAL.) Giornale THE HEALTH OF SMOKE3S, AND NONSMOKERS, di Gerontologia 16(8):852-4, Aug CHILDREN. Journal of Allorgy 43(6):336- Traiian (Abs.) 41, Jun 19637-----

In a large number of in-patients of this Hospital, aged up to 65 years, the B 11425 authors conducted a study of various Rosenblatt, M. B., Lisa, J. R., Teng, P., diseases in percentage. They found the and Beck, I. prevalence of chronic lung and heart VALIDITY co LUNG CANCER MORTALITY DATA. diseases. They point out the importance Bulletin of the New York Auadery of of preventive medicine in order to ,Medicine I3(Ers14=2777un 1969. realize an efficacious social welfare. (Author Abstract) B 11426 °olden, A. S. B 11375 WITH HOPE IN COLOMBIA. Clinical De Angelis, L. and Piscaglia, M. Pediatrics 8(4):246-50, Apr 1969. STUDIO SULLE CAUSE DI PENSIONAMENTO PER E/VALIDITA, NELLA PROVINCIA DI PESARO, RELATIVE AL QUINQUENNIO 1960-1964. (STUDY B 11431 OF THE CAUSES FOR PENSIONING FC9 INVALIDISM Metropolitan Life Insurance Company IN THE PESARO PROVINCE RELATIVE TO THE Statistical Bulletin. FIVE-yEAR PERIOD, 1960-1964.Folia Medica CANCER SURVIVAL AMONG WOMV IN RECENT 50(12)1966-76, Dec 1967, ItallER-MT77--- YEARS. Metropolitan Life Insurance company Statistical Bulletin 50:4-7, The causes of disability pensioning off FIKY-176-9. in the Province of Pesaro in the five-year period 1960-1964 have been studied by the authors, through the elaboration of data B 11433 pertaining to the sex, age, affected Anderson, D. L. organs and apparatus and work.They ORAL CANCER INCIDENCE AND MORTALITY underline that the cardiovascular diseases IN CANADA AND ABROAD.Journal of the by themselves represent 49.30 percent of Canadian Dental Associarl-Ko-n(r: disability causes, followed by pulmonary 192-7, ApF-1117. diseaces (14.87 percent) and by arthropathes (11.98 oercent).The study of varlovs statistical incidences can be of help for a very efficient prevention, apt

99 /05 B 11434 B 11510 Schroeder, H. A. Leke, B. THE WATER FACTOR. (EDITORIAL) MORBID CONDITIONS AT DEATH IN OLD MEN. New En land Journal of Medicine 280(15): Journal of Chronic Diseases 21(11-12): , pr0, 1969. 761,777 rik,-11747-

B 11449 B 11511 Gupta, S., Puri, R. K., Indira, O. C., Gilson, J. C. and Datta, S. P. RESPIRATORY DISEASES IN FARMING.Annals MORBIDITY IN CHILDREN UNDER FOURTEEN of Occupational Hygiene 12(2):121-77-W IN SQUTH INDIA. Indian Pediatrics iT6v. 5(11):485-97, Nov.I1737

B 11515 B 11450 Higgins, O. A., Lawton, R., Heilbrunn, Gregor, 0., Toman, R.,.Prusova, F., A., and Keehn, R. J. Drnkova, V., and Pastorova, J. PROGNOSTIC FACTORS 1N LUNG CANCER. GEOGRAPHICAL DISTRIBUTION OF STOMACH Annals of Thoracic Surgery. 7(5): CANCER IN CZECHOSLOVAKIA. nut 10(2): 472-86,1Ti7=7- 150-4, Feb 1969.

B 11516 B 11480 Medical Officer. de Villiers, A. J. SCOTTISH VITAL STATISTICS, 1968. THE EFFECTS OF AIR POLLUTION ON Medical Officer 121(12):161, Mar HEALTH, Occupational Health Review 21779T9. 20(3-4):2 , -g9.

B 11523 B 11492 Doll, R. Dean, G. THE GEOGRAPHICAL DISTRIBUTION OF THE CAUSES OF DEATH OF SOUTH AFRICAN CANCER.Britieh Journal of Car-1r DOCTORS AND DENTISTS. South African Medical Journal 43(17):05750r,-177- 23(1 ):1-1371UMS47 26, 196.9. B 11524 Jrurnal of the Indian Medical Association. B 11498 CANCER MORTALITY IN INDIA. Journal of Ea',..ional Center for Health Statistics. the Indian Medical Association(5): VITAL STATIST/CS OF THE UNITED 7r7,7IIFT, 1969. STATES 1966. SECTION 1--0EN2RAL MORTALITY. U.S. Department of Health Education, and Welfare, B 11545 Public Health Service, Washington, Staszewskl, J. D. C., Monthly Vital Statistics Report, CZY CZESTOSO RANA ZOLADKA W FOLSCE Provisional Statistics Report, National RIECZMSCIE WLRASTA? (IS sTmoii Center for Health Statistics, 2 (Part A) CANCER MORTALITY REALLY INCREASING :1-7--1-39, 1966. IN POLAND?)Novotwor 19(1).47-3, 1969, Polish s. 11499 National Center for Health Statistics. The age-adjusted stomach c'sr,ce VITAL STATISTICS OF THE UNITED STATES mortality rates in 24 countries fcr 1966. SECTION 2--INFANT MORTALITY. 1950-1963, as presented by Sei:,,t U.S. Department of Health, Education, al., were compared with the FollEn and Welfare, Public Health Service, rates for 1959-1966, adjusted Jri Washington, D. C., Monthly Vital the are way. The distinct decrease Statistics Report, Provisional of the rates in the 24 countries, Statistics Report, National Center (except Japan) is sharply contras1,71 for Health Statistics, 2(Part A): by the increasing rates observed Ir. 2-5, 1966. Poland. This increase however distinct only until 1963. It B 11506 that this increase was not real, Punt, N. A. but caused by the improvement of certification of the causes of des s. VOCAL DISABILITIES OF SINGERS AND ACTORS. Practitioner 202(1210:650-6, This explanation is based on t-.0 May 1969. fact that the increase of the :ates

100 104 B 11545 (continued) B 11560 was observed mainly in the old-age Sherwood, K. K. groups and in the rural population. MALIGNANCIES IN THE ELDERLY. It was accompanied by Pm increase of Northwest Medicine 68(5): the percentage of deaths certified 448-52, May 1969. by physicians in the rural areas, and also by a decrease of the percentage of deaths in which the cause was stated B 11567 as 'senility'. It ie concluded that Public Health Statistics, Department of in reality stomach cancer mortality Health, Pa. is starting to decrease in Poland too, NATALITY & MORTALITY STATISTICS 1968. esp. in females.Contrary to other Commonwealth of Pennsylvania Department esmcers, stomach cancer mortality in of Health, Bureau of Adminiatration, Poland is higher in the rural than Public Health Statistics 18(4):6-11, in the urban population. (Author Jan-Dec 196a, Abstract)

B 11566 B 11547 Lundin, F. E., Jr., Lloyd, J. W., Smith, Barzilai, D., Enat, R., and E. M., Archer, V. E., and Holaday, D. A. Haidenkrug, Y. MORTALITY OF URANIUM MINERS IN MQR WOW 'HR HWLY SPUN IPYR HYFH RELATION TO RADIATION EXPOSURE, HARD- Mhqr Nyswyr. (FOLLOW-UP OF ROCK MINING AND CIGARETTE SMOKING--1950 CANCER CASES IN THE CITY OF HAIFA. THROUGH SEPTEMBER 1967.Health Physics A Pilot Study.)Harefuah 76(5): 16(5):571-8, May 1969. 193-7, Mar 2, 196n9, ribTqw (Abs.)

A pilot follow-up study, the firEt B 11602 of its kind in Israel, was carried World Health Organization. out in the hospitals of Haifa during II. SPECIAL SUBJECTS. 1. MALIONANT the past year.This involved study NEOPLASMS IN CERTALI COUNTRIES. of hospital records and outpatient World Health Statistics Report 22(2): department files, and contact with tT6, 1969. the general practitioners in charge of the patients after discharge. The objectives were to compile an B 11604 accurate master file by means of British Medical Journal. Which long term treatment of cancer POINTS FROM PARLIAMENT.British cases can be studied, compared Medical Journal 2(5650:2M:79726, and evaluated) to ascertain how 1969. many cancer patients drop out of medical follow-up and whys and to restore to follow-up the patients B 11627 who drop out. From November 1, 1967, Sofoluwd, G. O. till the middle of October 19C8, 938 THE EFFECT OF ROU3ING CONDITIONS ON histological and cytological diagnoses PREVALEhCE OF BRONCHITIS-BRONCHIOLITIS of new caaes of cancer were made in the AND BRONCHOPNEUMONIA IN LAGOS, NIGERIA. hospitals of Haifa.The material ie West African Medical Journal 18(2): evaluated as to age, sex, mortality 3571.27X3F1'96777--- and type of cancer. There is no doubt that regional registration centers like the one being developed B11628 in the Haifa region (population Medical Officer. 300,000), will add imensely to the LUNO CANCER DEATHS.Medical Officer value of the National Cancer Registration 121(18):253, May 2, 1D69. Center, and contribute to the care and treatment of cancer patients. B11726 (Autho:, Abstract) Arztliche Praxis. ZIGARETTENRAUCHER LEBEN GEFAHRLICH. B 11558 (CIGARETTE SMOKERS LIVE DANGEROUSLY.) Arztliche Praxis 20(97):4820, Dec Alpers, X. H. 1968, OermETTATs.) 3, CHRONIC NON - TUBERCULOUS LUNO DISEASE 'T PORT MORESBY. P:pualanL'ew Guinea Journal llt ):1 tN,7reETTVN. A total of 54,460 male industrial edical workers (68.7 percent cigarette smokers). 40 years and older, under observation for 3 years, were arranged accordingto

101 B 11726 (continued) B 11746 (continued) their smoking habits and the cause of Republic of San Marino during the 17-ye death of the deceased during this period 1948-1965.During this period, period analyzed.Coronary thrombosis the annual mortality rate due to all (39 percent) was most frequent with an causes was 137 per 100,000 inhabitants, annual mortality of 2.7 percent; 13.9 figure which represents an overall rise percent died or lung cancer (0.4 percent over that of the preceding 40 years (90 annual mortality): noncancer- caused lung per 100,000). With regard to site, mal_ diseases resulted in only 7 percent of rant tumors of the digestive apparatus, deaths. Annual lung cancer mortality was including the stomach, alone cauaed a MK 1.2 percent higher in smokers than non- tality of 1C8 per 100,00 while those of smokers (0.3 percent). Incidence of lung the respiratory apparatus caused a morta cancer increased with rising cigarette ity of only 2 per 100,000. This latter consumption as well as with age and the figure is not only lower than that of th peculiarities of the smoking habit. Heavy total Italian population (18 per 100,000 smokers who retained cigarettes in the in 1961) but is also lower than that of mouth while exhaling were most endangered Emilia-Romagna and neighboring provinces (annual mortality of 4.1 percent).Annual (about 19 per 100,000). Statistics ac- mortality the to coronary thrombosis in cording to sex revealed a higher mortali younger smokers was 3 times as high as due to malignant tumors among men than in nonsmokers of the corresponding age women; according to age, the highest mor groups but only twice as high in older age tality was among those 60 to 75 years of groups. Cessation of cigarette smoking agt. With regard to habits, no exact reduced the risk of coronary thrombosis. statistics were available but the averag annual consumption of tobacco was report to approximate that of the adjacent B 11728 Italian population. Gerlach, H. A. DIE STERBLICHKEIT AN LUNGENKREBS IN DER BUNDESREPUBLIK DEUrSCHLAND 1952-1965. B 11774 (LUNG CANCER MORTALITY IN Th3 GERMAN Wlldner, G. P. and Klein, K. FEDERAL REPUBLIC 1952-1965.)Gesellschaft UBER DEN EINFLUSS EFIDEMIOLOOISCHER zur Bekampfung der Krebskrankheiten FAKTOREN AUF DIE HISTOLOOISCHE STRUKTUR 1787drhein4testarEn77771.111Wigadienst. DES BRONCHIALKARZYNOMS. (THE INFLUENCE 5(2):186-2M-CFE79W-berman(Ahs.; OF EPIDEMIOLOGICAL FACTORS ON THE HISTO- LOGICAL STRUCTURE OF BRONCHIAL CARCINOMA, Deaths due to lung cancer from Lelutsche Gesundheitswesen 24(22):1013-8, 1952 to 1965 have increased 126 FraT27;1§Trirsezmar) percent in males and 79 percent in females.Allowing for changes in In close correlation to the size of th the size and age structure of the living-place, the lung cancer morbidity i population between 1952 and 1965 the ODR has been doubling from the very the rate increases have been rural community to the big city. The ma] calculated as 80 percent for men population has been invariably affected 1 and 30 percent for women. Men, to 13 fold more frequently than tLe femal especially in the age groups of population. Whereas the morbidity rate c 55-60 years or older, were most the carcinomata of the histological group strongly affected, the more so /, the so-called "irritation cancers" ac- with increasing age. In women, cording to Kreyberg (aquamous c.11 car- the increase above the 40-45 cinomata, amall-cell careimeata and othe year age groups was approximately non-differentiated carcinomata) rose both the stow for all age grcr4s. The in the male and female population along mortality rate increases due to lung with the living place size, the morbidity cancer in tho observation period have rate of the carcinomata of group II (aden gradually become smaller. carcinomata, alveolar cell carcinomata, bronchus adenomata) did not increae among the female population. The potentie B 11746 muses for the different prognosis are riabloi, P., Dominiei, L, M., digotto, discussed. (Author Abstract) M. R., and Lomb. di, O. LA MORTALITA PER rumon MALIGN' NELLA REPUBBLICA DI SAN MARINO. (MORTALITY 13 11785 DUE TO MALIGNANT TUMORS IN THE REPUBLIC OF Public Health Statistics, Department of SAN MARINO.) Rivista Italiana d.Igiene Health. Pa. 28(1-2):5-25, an- pr 19S8, Italian tAbs.) NATALITY AND MORTALITY STATISTICS At..TUAL REPORT 1967. Commonwealth of Pennsyl- A statistical analysis is presented of vania Department or Health, Bureau cf trends in the incidence of cancer in the Administration, Public Health Statistics: /0102 B 11785 (continued) 6 11844 (continued) 6-11, 16-26, 28-31, 50-55, 73, expectancy for smokers in the 25- to Feb 15, 1969. 65-year age groups. The FTC recommendations concerning cigarette labeling and advertising on radio B 11792 and television were also mentioned. Roberts, N. J., Ipsen, J., Elsom, K. 0., Clark, T. W., and Yanagawa, H. MORTALITY AMONG MALES IN PERIODIC- B 11864 HEALTH-EXAMINATION PROGRAMS.New Fernan-Zegarra P, L. A., Chabes S, A., land Journal of Medicine 2811T): Rendon A, H., and Linares N, E. - , Jul 3, 19667 CIRROSIS HEPATICA EN EL HOSPITAL GENERAL DE AREQUIPA, PERU. (CIRRHOSIS OF THE LIVER IN THE GENERAL HOSPITAL B 11805 OF AREQUIPA, PERU.)Analee de la Lloyd, J. W. and Ciocco, A. Facultad de Medicine 671):567677 LONG-TERM MORTALITY STUDY OF STEEL- Jan-Mar 16T7, Spanish (Abs.) WORKERS. I. Methodology. Journal of Occupational Medicine 11TE7:299-610, The 1960-1966 case records (14,048 specimena) of the General Hospital were reviewed. Tables give the breakdowns of the different types of cirrhosis by age B 11836 and sex. Of 395 biopsies, 64 casea Heyden, S. (16.2 percent) revealed a cirrhosis; EINLEITUNG. (INTRODUCTION I. Deutsches of 982 autopales, 75 cases (7.6 percent) Medizinisches Journal 20(1 :2,Ta77.67 revealed the same disorder. The 1969, German (rs77r-- nutritivv form of cirrhosis placed highest (52 percent), followed by In his introductory remarks on obstructive cirrhosis (21 percent), preventive medicine on the occasion of congestive (18 percent), post-necrotic the 17th German Congress for Medical (6 percent) and post-hepatic (1 percent). Education, the author listed ischemic rof incidence of cirrhosis of the liver heart disease, cancer, and cerebro- in Arequipa, as evidenced by these vascular diseases as the three chief statistics, is high in comparison to causes of death. Early recognition other cities, but this may be offset of these conditions would impil:ve somewhat because of the inclusion of life expectancy. The role of nicotine congestive and pigmentary cirrhosis and inhalation was not sufficiently empha- because no age limits have been imposed sized in discussions on prevention of in compilation of the statistics. all three so-called chief causes of death. Diabetes and :idney diseases %ere also mentioned.The importance B 11877 of epidemiological studies LI connec- Higgins, I. T. T., Gilson, J. C., Ferris, tion with preventive medicine was B. 0., Waters, W. E., Campbell, H., and emphasized, with the hope that there Higgins, M. W. would be a closer conmntion between CHRONIC RESPIRATORY DISEASE IN AN the two in the future. The author also INDUSTRIAL TOWN: A NINE-YEAR referred to the 9-week course, the 4o- FOLLOW-UP STUDY. Respiration 26 called "Clinical Cancer Training (Suppl.):221-2, 1969. Course" given 3 times yearly at Duke University. B 11901 World Health Organization. B 11844 HEALTH EFFECTS OF AIR POLLUTION. Meinsma, L. World Health Organization Chronicle NIEUW RATPORT OVER HET ROKEN. (NEW 27111-mr=m, :Tin 1969. REPORT ON SMOKING.)Oeneeskundige Olds 47(1):4-5, Jan 2, 1969, DutEh 751-.) B 11909 Fan, K-Y. The findinga of the 1967 report STUDY ON THE CAUSES OF DEATH OF THE "The Health Consequences of Smoking", PEOPLE IN TAIWAN. Part 1. Study of the concerning the relationship between Reliability of the Cause of Death Described smoking and lung cancer, bronchitis, on the Death Certificates. Journal of emphysema, and cardiovascular dlseuses, the Fomosan Medical Association 68(17: were summarized.A table, presented 175-017W. 28, 1969. at the 1997 World Conference on Smoking and health shows the decrease in life

103 107 B 11916 B 12040 Cohen, J. and Steinitz, R. Palamidessi, C. UNDERLYING AND CONTRIBUTORY CAUSES OF ASPETTI DELLA MORTALITA TUMORALE IN DEATH OF ADULT MALES IN TWO DISTRICTS. GENERATE E DELLA MORTALITA PER NEOPLASIA Journal of Chronic Diseases 22(1):17-24, POUAONARE IN PARTICOLARE IN PROVINCIA DI Jun 1969. PISTOIA NEL SUINWENNIO 1962-1966. (ASPECTS OF TUMORAL MORTALITY IN GENERAL AND MORTALITY DUE TO PUIAONARY NEOPLASMS B 11922 N THE PISTOIA PROVINCE IN PARTICULAR IN Practitioner. THE 1962-1966 5-YEAR PERIOD.)Bollettino LUNG CANCER. Practitioner 202(1212): della Accademia Medica Pistoiese "Filip2o A93, Jun 1969. TaCTiii1"3-973-13=4IT715e-c196-8,Italian (Abs.)

B 11940 The tumoral mortality in the province Indul'ski, Ya. of Pistoia was above the national level. B.rwtsIECOWAJW 0AKTOP08 HAHETPX110010C06no0Tb Gastric tumors Predominated in both sexes, no 501E3H7. much above national averages. An increase VLIYANIYE SOISIAWNYKH FAKTOROV NA in lung cancer mortality was noted, but NETRUDOSPOSOBNOST' PO BOLEZNI. only in males; a modest increase was (INFLUENCE OF SOCIAL FACTORS ON WORK observed in mammary tumors in women and DAYS LOST FROM SICKNESS.) Gigiena 1 Prostate tumors in men. Pulmonary tumor Sanitarila 3T):72-8, Feb 1969, mortality per 100,000 inhabitants was Russian Abs. 1.8 percent below the national average. The incidence of pulmonary, mammary, and An analysis was made of the aicknyes uterine tumors appear at an earlier age and personal data records of 3,710 or with a tendency toward still lower age 53 percent of the 7,000 workers employed levels. The mortality for laryngeal and in a textile factory during 1961-62. tracheobronchopulmonary tumors appears to The work days lost because of sickness be linked with an increase in consumption were correlated with social factors such of tobacco: lung cancer mortality increas- as living and work conditions.Smoking ed 71 percent; consumption of cigarettes was one of the factors considered.Both increased 87.8 percent. The province 18 male and female smokers lost more work mainly agricultural, offering no valid days (calculated as a percentage of the comparison of urban and rural influences total work days) from sickness connected on the incidence of lung tumors. with the respiratory, digestive and nervous systems. Days lost as a result of accidents were also higher for smokers B 12117 than nonsmokers.On the other hand, Killer, L. H., Kramer, K., and Fisher, R. work, days lost as a reault of circulatory CHANGING TRENDS IN CIRRHOSIS AND lATTY diseases were higher for nonsmokers than LIVER MORTALITY.American Journal of for smokers, particularly in the case of Public Health and WITIggEroETTRalth women. It is speculated that one reason 's(7):1124-33,-Ja-I469. for this might have been the presence in the nonsmoking group of those people whose doctors, suspecting incipient B 12133 heart or vascular trouble, had forbidden Dvorak, L., Wolf, J., Broz, V., and them to smoke. Dvorakova, M. PREVENTIVNI PROHLIDKY PIINZSKYCH VYSOKOSKOLSKYCH STUDENTU A JEJICH B 11988 MEDICINSKA EFEKTIVNOST. (PREVENTIVE Stocks, P. MEDICAL EXAMINATIONS OF PRAGUE UNI- HEART DISEASE MORTALI1Y IN CITIES OF VERSITY STUDENTS AND THEIR MEDICAL LATIN AMERICA AND IN CITIES AND REGIONS EFFECTIVENESS.)Ceskoslovenske OF ENGLAND AND WALES.BulleAn of the Zdravotnictivi 17(7J:26 -72, 1969, World Health Organization 76617:40970, arch (Abs.) 1969. The authors give a brief account of the procedure used in contemporary com- B 12034 prehensive medical examinations and Geriatrics. periodic examinations at the Prague CHANCES OF SURVIVAL IN MEN WITH CANCER. University. They give an account of Geriatrics 24(8):204, Aug 1969. their positive and negative features and compare the precise requirements with the medical effectiveness of the examinations. They compare the results of the initial examinttion with those of the periodic

16g B 12133 (continued) B 12175 examinations after three years at the Sprott, D. A. and Forbes, W. F. University. The critical approach to MORTALITY RATES OF SMOKERS.Canadian the results of the compulsory mass Medical Association Journal 101(5): preventive examinations makes the 301-2, Sang, 1969. authors seek new ways to implement these examinations. (Author Abstract) B 12189 Werner, T., Sim, H. 0., and Woeber, Kh. B 12140 GESUNDHEITLICHE SCHADEN DURCH RAUCHEN. Statistical Bulletin. (HEALTH IMPAIRMENT DUE TO SMOKING.) MORTALITY FROM CARDIOVASCULAR DISEASES. Medizinische Klinik 694):143-51, Jan Statistical Bulletin 50:2-4, Jun 1969. 7.47-ro,9, GerEin-rEbs. Nicotinc, is a poison which shows B 12148 certain toxic effects due to its U. S. Department of Health, Education, and metabolism products and their toxic Welfare, Public Health Service. actions. Nicotine rarely acts as a SMOKING AND ILLNESS.U. S. Department free base, but enters the human body of Health, Education, and Welfare, mostly as a result of tobacco smoking. Public Health Service, Washington D.C., The smoker not only suffers an attack Public Health Service Publication No. as a result of nicotine, but also by 1662, Revised Apr 1969, 2Pp. gases such as carbon monoxide and through exposure to carcinogens and solids (e.g., the duet developed during B 12150 smoking which is an ideal areosol). Bell, J. A. E. Smoking thus induces a number of MORTALITY RATES OF SMOKERS. Canadila diseases like bronchial carcinoma and Medical Association Journal latrr: carcinomas of the upper respiratory 362-3, Sep 20, 1969. tract. Smokers suffer a higher incidence of bladder carcinoma, although the reason for this is not clearly understood. El 12157 Esophageal carcinoma is encountered more Mancuso, T. F. AND El-Attar, A. A. frequently in smokers than in nonsmokers. EPIDEMIOLOGICAL STUDY OF THE BERYLLIUM Carcinomas cause greater concern because INDUSTRY. Cohort Methodology and of their severity and mortality rate. Mortality Studies. Journal of More common is bronchitic syndrome due Occupational Medicine 11(8)3M-34, to smoking, and diseases of the heart and AlAg-1969. circulatory system. Complications of pregnancy may be induced by smoking, and stomach ulcers can also result. B 12164 Diseases r rare occasions caused by Damon, A. tobacco aret color blindness (when RACE, ETHNIC GROUP, AND DISEASE. tobacco and alcohol are used together Social Biology 16(2)369-80, Jun excessively), spinocerebellar ataxia, .19n. nnd disordera of the senses of taste and smell. Statistics in literature on the incidence of diseasea caused by nicotine B 12165 are grouped by sex and age. However, Stitnimankarn, T., Thakerngpol, K., findings from different countries and and Tansurat, P. Political divisions thereof are contra- AUTOPSY FINDINGS IN THE AGED POPULATION dictory where, locally, boundaries OF THAILAND. Archives of Pathology 88 between sex and age groups are not taken (2)3181-7, Aug-116-- into account.

B 12174 B 12201 Patterns of Disease. Lijecnicki Vjesnik. RESPIRATORY DISORDERS. Patterns of CIROZA JETRE U PORASTU. (CIRRHOSIS OF Disease (Special Report), Nov-Dec THE LIVER ON THE INCREASE.)Lijecnicki 1161174p. Vleanik 91(2)3267, 1969,Serbo-Croatia' (Abs)

IOS 109 B 12201 (continued) B 12322 Geriatrics. A table, based on statistics of the CHANCES OF SURVIVAL IN WOMEN WITH World Health Organization, presents 1965 CANCER. Geriatrics 24(9):57, Sep mortality statistics due to cirrhosis of 1969. the liver per 200,000 of the population in several foreign countries. Highest mortality (not shown in tablei was in B 12324 West Berlin (44.7 per 100,000 lowest Brunner, F. in Iceland (2.1) and Great Britain (2.9). CORONARY MORTALITY AND LIVING Cirrhosis of the liver was attributed to STANDARD. II. Coffee, Tea, viruses, bacteria, toxic substances, and Cocoa, Alcohol. and Tobacco. Acta nutritional deficiencies induced by Medica Scandinavica 186(1-2):3.1=3, alcoholism (three times as high in TirMagIR-4. alcoholism). Mortality was highest in older people and in males. B 12346 Haltvi, H. S. B 12236 PATTERNS OF HOSPITALIZATION IN ENGLAND Haas, M. AND ISRAEL.British Journal of TCWARD THE STUDY OF BIOPOLITICS: A Preventive &TOCTITi-miaTare23(3): CROSS-SECTIONAL ANALYSIS OF MORTALITY 196-202, Aug rurg:- RATES. Behavioral Science 14(4):257 -80, Jul 1969. B 12348 Gardner, M. J., Crawford, M. D., and B 12262 Morris, J. N. Schilling, R. S. F. PATTERNS OF MORTALITY IN MIDDLE AND CHANGING CONCEPTS IN OCCUPATIONAL HEALTH. EARLY OLD AGE IN THE COUNTY BOROUGHS American Journal of Public Health and the OF ENGLAND AND WALES. British Journal Nihon's Health 52T8):1366-7571%-70.67 of Preventive & Social Medicine 23(3): 133-40, Aug 193.9.

B 12278 Kruegel, D. L. B 12349 ESTD4ATED PREVALENCE OF CHRONIC CONDI- Crofton, E. C. TIONS IN KENTUCKY. Journal of the A STUDY OF LUNG CANCER AND BRONCHITIS Kentucky Medical Association-67UT:665-7, MCRTALITY IN RELATION TO COAL-MINING Sep 969. IN SCOTLAND. British Journal of Preventive & Social Me3ra7W-23r3): rir:T7Trg B 12280 Cooper, D. L. WHAT IS FITNESS? Physical Fitness, B 12377 Tranquility, and Love of Fellow Man Hammond, E. C. are Essentials of Happiness. Rhode LIFE EXPECTANCY OF AMERICAN MEN IN Island Medical Journal 52(8):4 RELATION TO THEIR SMOKING HABITS. Arrg-10627 Journal 1,1 the National Canoe 40 :951-62, Oct 1969.

B 12281 Belamaric, J. B 12394 MALIGNANT TUMORS IN CHINESE. A Report Thorarinsson, H. Based on Biopsy and Autopsy Material CARCINOMA OF Ti E LUNG IN ICELAND. A from Chinese in Hong Kong. Inter- Summary and Some Reflections Concern- national Journal of Cancer 41Tfir60- ing More Recent Principles for Diagno- 73, Jul 15, 1960. sis and Treatment. Scandinavian Journal 21 Thoracic and Cardiovascular Surgery 311)01-8, On. B JP308 an,G. B 12398 THE SEED FCR ACCURATE CERTIFICATION Assel, N. R. and Lindeman, R. D. OF THE CAUSES OF DEATH AND FCR MORE GEOGRAPHIC AND SECULAR VARIATION IN AUTOPSIES. Journal of the Irish MORTALITY FROM MALIGNANT DISEASE IN Medical AssoTiTarrn 32(3106)7273=8, Journal of the Aug 1069. 0111ASOKA 1956-1965. Oklahoma State Medical 62(9)1424.7337Sep 1969.

106 0 B 12402 B 12504 (continued) Statistical Bulletin. acquisition of knowledge. It must generate CHANCES OF DYING FROM IMPORTANT CAUSES. a demand for optimal health and produc- Statistical Bulletin 50:2-4, Jul 1969. tivity. Ways and means to bring this about are, as a rule, not available to the doctor. B 12432 Leutner, R. STATISTISCHE UNTERSUCHUNOEN ZUM B 12511 HERZINFARKT. (STATISTICAL IN- Stubna, J., Makovicky, E., Hudakova, 0., VESTIOATIONS OF MYOCARDIAL IN- and Estok, S. FARCT.) Arztliche Praxis 21(30): NIEKTORE ZVLASTNOSTI CHOROBNOSTI CIGANOV 1759, 1779, Apr 15, 1969, Oerman VO SVETLE ZIST'OVANIA CELKOVEJ CHOROBNCSTI (Abs.) OBYVATEL'OV V OKRESE KOSICE A BARDEJOV. (SOM3 PECULIARITIES OF OYPSY MORBIDITY IN Mortality due to coronary disease has RELATION TO THE OENERAL MORBIDITYOF THE increased considerably in middle Europe POPULATIONIN THE DISTRICTS OF KOSICE AND since the last war, reflecting the in- BARDEJOV.) Ceskoslovenske Zdravotnictvi dustrialization in those countries. A 17(9):377-63, 1969, Czech (Abs.) table shows the standardized mortality due to diseases of the circulatory sys- The health status of the gypsy tem, arranged by sex, from 1952 to 1962 population in Slovakia is the consequence in six countries, West Oermany, England of many years backwardneas in the economic, and Wales, France, Italy, Sweden, and cultural and social sphere. So far we pos- the United States.Another shows the sess relatively little information on ths standardized mortality due to coronary morbidity of gypsies. In the present disease for the same period in four of paper the authors submit some data on the countries (excluding France and the general morbidity of the gypsy popula- Sweden). Males were more seriously tion in the districts of Kosice and affected than females. Bardejov in 1962. In an investigation of the general morbidity of the population of these districts relatively ample B 12477 material was assembled on the morbidity U. S. Department of Health, Education, of gypsies which permits a more detailed and Welfare, Public Health Service. analysis and supplementation of data by THE HEALTH CONSEQUENCES OF SMOKING. differential characteristics from a re- 1969 SUPPLEMENT TO THE 1967PUBLIC peated survey of the morbidity made in HEALTH SERVICE REVIEW.U.S. Department 1967. In the paper the authors draw of Health, Education, and Welfare, Public attention to some peculiar features and Health Service Publication No. 1696-2, specific traits in the morbidity of 1969, 98 pp. gypsies which is in general more adverse as compared with the remaining population. (Author Abstract) B 12504 Scher, M. LEBENSOEWOHNHEITEN UND PRAVENTIVMEDIZIN, B 12519 (LIVING HABITS AND PREVENTIVE MEDICINfi.) American Cancer Society, Inc. Zeitschrift fur Praventivmedizin 14t1): 1970 CANCER FACTS AND FIGURES.American 19-24, Jan-FITS-1D59, German (Abs.) Cancer Society, Inc., New York, N. Y., 1969, 31 pp. The problems of preventive medicine are viewed as more complex than the prevention of diseases and accidents, and B 12527 are not specifically medical but also National Center for Health Statistics. educational in influencing living habits BIRTHS, MARRIAOES, DIVORCES, AND DEATHS of people and technical in coping with the FOR JULY 1969. U.S. Department of Health, environment. The environmental factors as Education, and Welfare, Public Health caueea of health disorders are doubtless Service, Washington, D. C., Monthly Vital overrated while unhealthy living habita Statistics Report, Provisional Statistics are not given sufficient attention.The Report 18(7):1-8, Sep 30, 1969. morbidity and mortality due to cardiovascular diseases and some forms of cancer can be reduced more sharply by B 12530 changes in living habits than by early Holland, W. W. diagnosis and treatment. Health educa- VITAL STATISTICS.Medical Annual 671 tion which has, as a goal, a healthy way 543-58, 1969. of life must not be limited to mere

107 /11 B 12536 B 12607 (continued) Department of National Health and Welfare, BRONCHOOENIC CARCINOMA IN THE HOSPITAL Canada. OF ONCOLOGY OF THE NATIONAL MEDICAL 'HE ESTIMATED COST OF CERTAIN IDENTIFIABLE CENTER, MEXICAN INSTITUTE OF SOCIAL CONSEQUENCES OF CIGARETTE SMOKING UPON SECURITY.) Gaceta Mediae de Mexico HEALTH, LONGEVITY, AND FflOPERTY IN CANADA 99(9):859-6775771069, 50anighTKEs.) IN 1966.Department of National Health and Welfare, Ottawa, Canada, 1969, 31 pp. Causes of bronchogenio cancer at the Oncology Hospital between 1962 and 1967 are presented and their relative frequency B 12541 by year are cored in order to study Muse, H., Sachs, H., and Pauka, B. their possible rise in relation with EPIDEMIOLOGISCHE UNTERSUCHUNG BOSARTIGER other C61308 at the hospital. An increment NEUBILDUNGEN IN HAMBURG 1960-1962. in the absolute and relative number of (EPIDEMIOLOGICAL STUDY OF MALIGNANT bronchogenic cancer cases were registered NEOPLASMS IN HAMBURG IN 1960-1962.) in the period indicated.This increment Zeitschrift fur Krebsforschuna 73(1): was noted in males as well as females' and 1-45, 1969, merman (Abs.) in all the hietopathologic types determined from the disease. The number of Cancer registration has been practiced cases in several subgroups is too small to in Hamburg for more than 30 years.The make valid conclusions.Approximately 84 statistics obtained are the beeie for percent of the patients were smokers, of this study which shows that in 42 dis- which 62 percent smoked more than 20 tricts of Hamburg regional differences in cigarettes a day. In the nonsmoking group cancer mortality were not caused by chance. the women with adenocarcinoma were With age-adjusted data using the chi- noticeable. It is thought that the rue square method for women, regional in bronchogenic cancer at the Oncology differences in cancer mortality were Hospital is due to the improvement in the found for tumors of all localizations, diagnoetic capacity of the medical staff especially for carcinomas of the cervix of the Mexican Institute of Social Securi- and corpus uteri, ovary, etomach, liver, ty without being able to ,establish the and gallbladder; for men differences relative importance of carcinogenic were found only for all localizations of environmental factors in the case of carcinoma and for carcinoma of the colon bronchogenic cancer.The study of the and respiratory tract. (Author Abstract) frequency of bronchogenic cancer in Mexico ie a requieite to determine if there is actually an increment in the B 12542 disease as well as to study some possible Statistical Bulletin. causative factors that could reduce the CANCER MORTALITY AT MIDLIFE. frequency of the disease. Statistical Bulletin 50:2-5, Aug 1969. B 12618 B 12551 Boletin del Institute Intemmericano del Hammond, E. C., Selikoff, I. J., and Nino. Lawther, P. J. EFECTOS PERJUDICIALES DEL CIGARRILLO. INHALATION OF BENZFYRENE AND CANCER (HARMFUL EFFECTS OF CIGARETTES.) IN MAN. Presented at the First Fall Boletin del Inatituto Interameritano Scientific Assembly of the American 5717T1WoT1-611122-7, Mar 1969, College of Che ."lysicians, Chicago, nThriFTAbs. Illinois, Oct .969, 12 pp. A brief hietorical review is made of studies which have related emoking to B 125 88 lung cancer and other diseases.By 1951 Elmes, P. C. and ';Impson, M. statistical studies had shown a greater RETROSPECTIVE MORTALITY STUDIES ON mortality rate among cigarette smokers PIPE COVERERS. British Em ire Cancer than among nonsmokers, with little Campaign for ReanFMAnnua FaiFf difference between the mortality of 16t456- LDT!. nonemokere and pipe and cigar smokere. Theae studies also showed a relation between the mortality of smokers and B 12607 the number of cigarettes smoked. In G4rcia-Sainz, M. 1962, 4120 men with no signs of coronary FRECUEFCIA REIATIVA DLL CARCINOMA diseaee enrolled in a study in which they BRONCOOENICO -EN RL HOSPITAL DE were examined periodically over several ONCOLOGIA DEL CENTRO MEDICO NACIOHAL years. The morbidity and mortality due I.M.S.S. (RELATIVE INCIDENCE OF to heart disease was much greater among

172. B 12618 (continued) B 12658 those who smoked.Stomach and duodenal Case, R. A. M., Harley, J. L., and ulcers in smoker: heal more slowly be- Coghill, C. cause of the toxic effect of nicotine MORTALITY STUD/ES.British Empire and the irritative action of tobacco Cancer Ca i for MEDI% Annual derivatives in the saliva. In examining Egan ar reasons for smoking, some people use cigarettes to calm their anxiety and reduce tension, some emoke only for )3 12680 pleasure, others smoke by invitation Elmes, P. C., Langlands, J. H. M., Wallace, or to pass the time, and there are W. F. M., Simpson, M., Cassidy, E., and the true addicts.Because it is Wade, O. L. difficult to stop smoking, the use REPORT OF INVESTIGATION OF DISEASE AMONGST of filters or cigars And pipes is PIPE COVEREES. British Empire Cancer suggested as a partial solution. Ca i . for ResWER57-ArffiraI-R;53R Investigations are being conducted to r 77115-6, 1966.------find filters and other methods of neutralizing the toxic substances of tlcco. B 12706 Potekhina, M. V.

B 12621 mEKOTOPUE 0C060-HOC111 womobeiccnn Medicine. HAUPDVIA noamitox 11 CWWECKOKK,43PACTOK. SALUD Y TABACO. (HEALTH AND TOBACCO.) Medicine 28(9:413-4, Nov-Dec 1968, NEKOTORY1E OSOBENNOSTI ZABOLEVAiEMOSTI ETEZTirlAba. NASELENIYA POZHILY101 I STARCHESKIKM VOZRASTOV. (SOME PECULIARITIES OF From the publication of the 1964 MORBIDITY AMONG THE POPULATION OF THE Surgeon General's report, which ,:wakened AGED AND SENILE.)Sovetskoe many people who had doubted the deleteri- Zdravookhranenie 2817;131-7, 1969, ous effects of cigarettes, to the latest Russian (Abe.; report (The Health Consequences of Smoking, 1968, supplement to the 1967 Public Health The article is devoted to morbidity Review), the statistics and investigations among the population of old and senile have multipled that affirm the harmful age. The data of copies from primary effects of cigarettes on the life expec- documentation obtained for 5 years were tancy of the smoker (2 packs a day for 25 compared with the materials of complex year-old smoker diminishes his life expec- medical examinations. Under observation tancy by 8.3 years). The youth are begin- were more than 2000 persons aged over 60, ning to realize this - 94 percent of a residing in Kaluga wi.hin the limits of 6 large number of adolescents interviewed territorial therapeutic districts. It was believe cigarettes are harmful.Almost 80 established that the level of morbidity percent either thought they would quit fluctuates from year to year quite smoking or had never smoked. In the U.S., insignificantly.Chronic and protracted 100,000 doctors have quit smoking and 90 diseases are mostly spread among individ- percent of all U.S. doctors believe there uals of old and senile age.Complex is an association between smoking and lung pathology le rather frequently observed. cancer, chronic bronchitis, emphysema, Persona of older ages, getting used to peripheral vascular disease, and coronaries. their afflictions, do not take medical In a comparative study of a city in New advice for years.Therefore even accord- Hampshire and in England, the incidence of ing to the data of three-year attendance, chronic bronchitis was 10 percent in non- a complete comprehension could not be smokers and there was an ascending curve achieved concerning the spread of chronic in direct relation to the number of daily diseases. It is necessary to attach cigarettes smoked up to 60 percent in 2- special importance to medical examination pack-a-day smokers. Cancer of the bladder in studying the state of health in persona seems to be associated with the use of of old and senile age. (Author Abstract) tobacco. An appeal is made for doctors to set an example and to quit smoking, and for the government not to favor the plant- B 12723 ing of tobacco in virgin farmlands and to Kay, C. R., Smith, A., and Richards, B. gradually reduce its production where it SMOKING HABITS Of ORAL comnAcsrpres already exists. USERS. lancet 2(7632)11228-9, Dec 6, 1969.

109 113 B 12736 13 12816 Hill, I. O. W. Petrakov, B. D. MUST WE WEAR OUT?Canadian Famil Physician 15(11):157Trn, 23 Fov 3A60reobEriocT, N 01EPTHOCT' OT 3110KAIIXECT- 1KE41WKX HOK006PA3OXAH4U MACEAEHNNA X XOGPACTE AO 30 PET (no MATERAAAAM 3APEZE3)O10U 0TAniC7M11).

B 12752 ZABOLEVAYEMOST, I SMERTNOST' OT Newhouse, M. L. ZLOKACHESTVENNYKFINOVOOBRAZOVANIY A STUDY OF THE MORTALITY OP WORKERS IN NASELENIYA V VOZRASTE DO 30 LET (to AN ASBESTOS FACTORY.British Journal MATERIALAM ZARYBEZI1NOY STATISTIKI). of Industrial Medicine-271717211=7M7 (MORBIDITY AND MCRTAIJTY PROM Tit-71777-- MALIGNANT NEOPLASMS IN POPULATIONS AGED 30 YEARS AND UNDER (BASED CV FOREIGN, i.e. NON-RUSSIAN, STATISTICS).) B 12753 Zdravookhranenie Rossiiskoi Federatsil Desai, J. R. and Vyas, B. K. 13t7):38-42, Jul 1969, Rusgaigrni7T- MORTALITY AND MORBIDITY IN PEPTIC ULCER SURGERY. Indian Journal cf Surgery Comparative statistics for morbidity 31(4):372-171a-417=9. from malignant neoplasms, gatherea from the economically developed countries in Europe, North America, and Oceania, are B 12760 given for the years 1959-61 and 1963-65. Statistical Bulletin. The data are broken down by age group POLICYHOLDER MORTALITY SHOWS LITTLE (0-29 years and 50 -64 years), and by CHANGE. Statistical Bulletin 50: sex. Available data on the incidence 10-1, Sep 1969. of cancer by site on young people in these countries are also presented. B 12809 Karecsony, 0., Ormos, J., Biliczki, P., and Szonyi, F. A TUDORAK SZEOEDEN. (PULMONARy CANCER See alsoC10402,C 10850, C 11006, IN THE MUNICIPALITY OF SZEGED.)Orvosi um-393, C 11456, C 11668, C 12500, Hetilap 109(17):921-5, Apr 28,19r17-- E 10804, E 10993, E 11100, E 12190 fringArian (Abs.)

A documented clinical record for 239 pulmonary cancer cases-10,124 autopsies performed on patients over 20 years of age-covers the period from 1921 to 1959 for the municipality of Szeged and its satellite area. The study covered all economic and social cross sections of the population. While the incidence rate was higher in the air-polluted industrial districts of the city or among workers exposed to smoke (waiters, train con- ductors, foundry workers) the record still confirms the investigation0 of Doll and Hill that there is a linear relationship between the daily dosage of (nicotine) smoking, carcinoma and mortality. The wishful thinking that adenocaroinoma has no apparent relationship to smoking cannot be supported by the studies.The studies have also confirmed the inseparable relationship between cancer and habitual smoking. Tables related to the broad spectrum of various centers, calendar year, sex, as well as the results of the autopsies are presented.

110 /14 SECTION C. NEOpLASTIC DISEASES

C 10188 C 10192 (continued) Ishii, K., Nakamura, K., Ozaki, H., the healthy side. The statistics were Yamada, N., and Takeuchi, T. too scanty to verify the reported SUIZOGAN NO EKIGAIGI NI OKERU relationship of smoking as an etiological MONDAITEN. (SOME ASPECTS OF THE factor in the development of bronchial EPIDEMIOLOGY OF CANCER OF THE carcinoma. PANCREAS.) Nippon Rinsho 26(8)1 1839-42, Aug 1968, Ilipiriese (Abs.) C 10195 With the cooperation of 101 Golubtsov, F. S. hospitals, a questionnaire survey XPOHMECKYGi 6PO-DITT 11 PAXminKro. was made of the smoking and dietary habits of 1,282 people in Japan, KHRONICHESKIY BE'NKRIT I RAK LEOKOGO. diagnosed as having pancreatic (CHRONIC BRONCHITIS AND LUNG CANCER.) cancer. Usable data were obtained Sovetskaya Meditsina (3):129-30, 1968, about 475 people (309 men and 166 Russian (Al>s.) women). The relative risk of cancer of the pancreas from smoking and Chronic bronchitis had Preceded lung from different items of diet was carcinoma in 269 of 374 patients who had calculated by comparison with undergone radical lung surgery.The similar statistics for a control majority (230 of 269) were in the 40-60 population of 260,000 healthy year age group, and of these 269 patients, adults. The latter stat:katics 251 (93.3 percent) were smokers of whom were obtained from 29 health 64.3 percent had smoked core than a pack centers distributed throughout of cigarettes for at least 20 years. Japan. The results are presented Chronic bronchitis not linked with in a series of graphs. It is smoking was present in only 18 patients. considered that the relative risk of Grippe and measles which also could lead cancer of the pancreas from smoking to bronchitis wereactedon snamnesis in is considerably greater than from 51 of the 269 patients; 48 of the 51 were dietary factors. smokers.Ninety-one of the patients (34 percent) of whom 88 were smokers had suffered earlier from pneumonia. There C 10192 was great interest in squamous cell Liokis, Th. carcinoma (201 cues, 74.7 percent) when LE CANCER BRONCHIQUE CHEZ DES FUMEURS chronic bronchitis was associated with EN MILIEU SANATORIAL. (BRONCHIAL lung cancer. The percentage was higher CANCER IN SMOKERS IN A HOSPITAL in the central form, 82.7 percent (110 of ENVIRONMENT.) Brooches 161386-91, 133) and lower in the peripheral, 66.1 Sep-Oct 1966, Frerial (Abs.) percent (90 of 136).

Of 65 cases of bronchial cancer, only 1 was a nonsmoker. Thirty-four C 10196 had smoked more than 25 cigarettes Orlovskiy, L. V. per day for many years; several had 3-1A4D-VIECOW.VICI-nin1EW4ECK1SX0MMAPV4t0nPA smoked more than 60 cigarettes per 113Y4E1-141 PAO. day. Most of the patients were from rural regions of Greece and several 2NACHENIE SOTSIALPNO-GIGIENICHUKIKH were tobacco growers who had smoked ISSLEDOVANIY PRI I2YCHENII PAKA. home-made cigarettes often wrapped in (SIGNIFICANCE OF THE SOCIAL-HYOTENIC ordinary newsprint. The latter cate- INVESTIGATIONS IN THE STUDY OF CANCER.) gory had a very rapid evolution of Gi iena i Sanitarlia 33(6)01-3, 1968, bronchial carcinoma. Ages ranged from U93 an TAU177------42 to 82 years with the greatest incidence in the 50-69 year age group. The Institute of Health Education in Most cancers were localized in the Moscow has conducted a 10-year large bronchi, especially in the upper epidemiological investigation of cancer lobes of the right bronchial tree. by means of expeditions to extremely Biopsies in 33 cases revealed 24 diverse climato-geographic areas of the epidermoid carcinomas, 5 oat-cell Soviet Union, among different ethnic carcinomas and 4 adenocarcinomas. groups with dissimilar working and Eleven of the cancers were associated living conciitions and with different with pulmonary tuberculosis, 9 on the nutritional habits. Certain cancer same side as the carcinoma and 2 on localizations were noted. Destro-

kik 115 C 10196 (continued) C 10219 (continued) intestinal cancers were found in A Less Harmful Cigarette.U. S. populations violating proper rules of Department of Health, Education, and nutrition (drinking too-hot tea, for Welfare, Public Health Service, example). Skin cancers, especially of National Cancer Institute Monograph the face, were found most frequently in No. 28, Jun 1968, pp. 57-63. the southern regions of the country, especially among sun-exposed shepherds, sailors, etc., wearing headgear which C 10246 did not shade the face.A high Arndt, J. H., Sears, A. D., and incidence of oral cancer was found among McNamara, J. J. males using "nes", a tobacco-ashes BRONCHIOLAR CARCINOMA OF THE LUNG. mixture. The incidence of lung cancer Texas Medicine 64(11):70-5, Nov 1968. was always highest among smokers. Mammary cancers and abortion were rarely found among primitive Central C 10256 Asian women who were known fcr pro- Fullmer, C. D. tracted breast feeding of f.nfants. CYTOLOGICAL ASPECTS OF LONG-TERM CIGA- Apparently, this assisted in the RETTE SMOKING. Canadian Journal protection of physiological functions MeMdicalTechnology 30(6T:249-53, Dec serving as a prophylactic measure against r-- mastopathy or other precancerous diseases. The author stressed the necessity for instituting proper C 10272 sanitary practices which take into Virginia Health Bulletin (Series 2). account the present unhygienic customs WHAT IS CANCER? Virginia Health of the populations. Bulletin 21(6, Series 2):27127-15ct 1968.

C 10273 C 10209 Knox, J. F., Holmes, S., Doll, R., and Muta, N. Hill, I. D. HANIKUGAN NO CHIRYO SEISEKI. (RESULTS MORTALITY FROM LUNG CANCER AND OTHER OF TREATMENT OF CARCINOMA OF THE GUM.) CAUSES AMONG WORKERS IN AN ASBESTOS Nippon /gar Hoshasen Oakkai Zasshi TEXTILE FACTORY.British Journal of 2 (3 :336-, Jun 1968,TOgrie3iU6s.) Industrial Medicine 25(4):213-303, Oct 1968. Of 19 males with carcinoma cf the gum, one did not smoke, 5 smoked "a few", 5 smoked 10 cigarettes per day, and 8 C 10278 smoked more than 20 cigarettes per day. Rubin, P. Of 6 women with carcinoma of the gum, COMMENT: AN OCCUPATIONAL DISEASE. 4 did not smoke, one smoked 10 Journal of the American Medical cigarettes per day and one smoked i-g-s-FirrtliTing56(8):1775-t721.3718, 1968. more than 20 cigarettes per day. These statistics are reported, without comment or conclusions, in a paper C 10279 concerned mainly with details of treat- Shende G. Y. ment. INDIANNDIAN PRACTITIONER CARCINOMA OF THE LUNG. Indian Practitioner 21(7):473-80, Jul 196r---- C 10216 Bross, I. D. J. EFFECT OF FILTER CIGARETTES ON THE RISK C 10284 OF LUNG CANCER. In: Wynder, E. L. and Nebraska State Medical Journal. Hoffmann, D. (Editors). Toward A Leas RESPIRATORY DISEASES. SMOKING, Harmful Cigarette.U. S. Department of SPUTUM, AND LUNG CANCER.Nebraska Health, Education, ar.' Welfare, Public State Medical Journal 53(17rm2, Health Service, National Cancer Institute Monograph No. 28, Jun 1968, pp. 35-40. C 10291 sock, F. G. C 10219 THE NATURE OF TUMOR-PROMOTING AGENTS Bock, P. G. IN TOBACCO PRODUCTS.Cancer Research DOSE RESPONSE: EXPERIMENTAL 28 {11)12363 -8, Nov 196r---- CARCINOOENESIS. Ins Wynder, E. L. and Hoffmann, D. (Editors).Toward

112 10298 C 10328 U. S. Department of Health, Education, and Sottosanti, M. Afare, Public Health Service. SUL 6CARCINOMA A CELLULE GIGANTI" DEL CANCER OF THE BLADDER.U. S. Department POLMONE. ("GIANT CELL CARCINOMA" OF of Health, Education, and Welfare, Public THE LUNG.) Gazzetta Internazionale Health Service, Bethesda, Md.Health di Medicine e CHirurgia 72{24): Information Series No. 145, NIH Publica- 0135-58, Dec 3I, 1967, Italian (Abs.) tion (29;, 1968, 8 pp. After a review of reports on giant cell carcinoma of the lung, the author C 10299 outlines the anatomo-pathological and Lynch, H. T., Krush, A. J., Slowlnski, clinical picture.He then describes E. J., and Marsh, M. F. three cases of this type of lung cancer SCIENTIFIC EXHIBIT: CANCER FAMILIES, observed by him and concludes with a A HEREDITARY CANCER SYNDROME.Nebraska number of considerations on the State Medical Journal 53(11)152T7307--- particular neoplastic form studied. avr9m---- All were smokers (40, 30 and 15 cigarettes per day, respectively) but there was no correlation of the smoking C 10309 habit with the neoplastic formation. Yoshida, 0., Miyakawa, M. Harada, T., and Okada, K. BOKOGAN NO EKIGAKU NI OKERJ MONDATTEN. C 10342 (SOME ASPECTS OF THE EPIDEMIOLOGY OF American Cancer Society. URINARY BLADDER CANCER.) Nippon Rinsho AMERICAN CANCER SOCIETY ANNUAL REPORT 26(8):1850-4, Aug 1968, Japanese (Abs.) 1967. American Cancer Scalety, 1967, 20 PP. From data collected in 1962, a significant association is found between cigarette smoking and urinary bladder C 10345 cancer in both males and females.The Hadley, h. G. relative risk is 3.4 for males and 3.9 RELATIVE IMPUIVANCE OF HEREDITY AND Journal of the for females. When the data for males ENVIRONMENT ON CANCER. are analyzed by amount of smoking, the Fey tiara Medical Associalfon 51(T7:--- relative risk for male heavy smokers is - 1, 1W87--- found to be 4.4. C 10346 C 10324 Dunham, L. J. Zanotelli, F. and Besa, G. A GEOGRAPHIC STUDY OF THE RELATIONSHIP IL CARCINOMA BRCNCHIOLO-ALVEOLARE. BETWEEN ORAL CANCER AND PLANTS. Cancer CONSIDERAZIONI SU DI UN CASO. Research 28(11):2369-71, Nov 1968. (BRONCHIOLO-ALVEOLAR CARCINOMA. OBSERVA- TIONS ON ONE CASE.) Giornale Italiano delle Malattie del ToaFrtgzpi51,1 C 10347 MST:104-1'9, Nov-Dara7, Italian (Abs.) Rose, E. F. THE EFFECTS OF SOIL AND DIET ON DISEASE. The authors show a case of bronchiolo- Cancer Research 28(11):2390-2, Nov 1968. alveolar carcinoma in a 56 year-old man. The symptoms were in a dominant manner persisting pains in the right lower limb. C 10356 The respiratory system disorders appeared U. S. Department of Health, Education, la.er. A bilateral bronchiolo-alveolar and Welfare, Public Health Service. carcinoma was suopected and the possibili- CANCER OF THE URINARY ORGANS.U. S. ty of a surgical therapy was excluded, Department of Health, Education, and therefore an antiblestit:, therapy was Welfare, Public Health Service, National applied, but unsuccessfully. The authors Institutes of Health Publication (30): point out that this patient died owing to 131-9, 1966. a massive haemorrhage due to a duodenal ulcer together with thrombophlebitis in the left lower limb, and not to respira- C 10371 tory insufficiency. (Author Abstract) Fonts, E. A., Greenlaw, R. H., Rush, B. F., and Rovin, S. VERRUCOUS SQVAMOUS CELL CARCINOMA OF THE ORAL CAVITY. Cancer 23(1)1152-60, Jan 1969.

117 C 10380 C 10410 (continued) Kreyberg, L. NONSMOKERS AND THE GEOGRAPHIC The smoking history of 150 lung PATHOLOGY OF LUNG CANCER. In: Liebow, cancer cases (121 men and 29 women) A. A. and Smith, D. E. (Editors). was determined. These cases were The Lung, by Twenty-five Authors. classified as: heavy smokers (over International Academy of Pathology cigarettes a day for over 21 years); Monograph. Baltimore, Md., The medium smokers (10-19 cigarettes a day Williams and Wilkins Co., 1968, pp. for over 11 years or more than 11 273-83. cigarrettes a day for 11-20 years); light smokers (lees than 10 cigarettes a day for more than 10 years or more C 10589 than 10 cigarettes a day for less than Lynch, H. T. 10 years); and non-smokers. Using "CANCER FAMILIES:"ADENOCARCINOMAS this classification as a measure of (ENDOMETRIAL AND COLON CARCINOMA) extent of smoking, correlations are AND MULTIPLE PRIMARY MALIGNANT made between .;r.ent of smoking, age, NEOPLASMS. In: Recent Reaults in sex, tumor type, chest x-rsy picture, Cancer Research, No. 12, 1967, extent of surgery and where in the pp. 125-42. lung the tumor originated.

C 10395 C 10418 Registrar General's Statistical Review Simeckova, B. of England and Wales for the Year 1962, PLICNI RAKOVINA U ZEN. (LUNG CANCER Part III. IN WOMEN.) Rozhledy v Tuberkt.lose CANCER OF THE LUNG AND BRONCHUS. In: a v Nemocech Plicnicn728[FTT------Registrar General's Statistical 565-17-5W108, Czech (Abs.) Review of England and Wales for the Year 1962, Part III, 1965, pp. 164-72. In a aeries of 107 cases of lung cancer in femalea, in 98 of whom the histological type of neoplasm could C 10401 be determined, the author failed to Mortimer, R. H. and Campbell, C. B. record any employees of the ASBESTOS EXPOSURE AND PLEURAL Czechoslovak railways, despite the MESOTHELIOMAS. Medical Journal of fact that amongst males with lung A tralia 2(17)020-2, Oct 26, lgTB. cancer this type of employment was significantly more common statistically then 1.: the total population, and C 10402 despite tne fact that one third of U. S. Department of Health, Education, the railway employees are women. and Welfare, Public Health Service. Only 4 of the 55 women whose :smoking END RESULTS IN CANCER.Report No. 3. habits were recorded were actually U. S. Department of Health, Education, smokers, three of them smoked lees and Welfare, Public Health Service, than 3 cigarettes per day. Coincidence Washington, D. C., National Institutes with tuberculosis was equally frequent of Health Publication 30:4-33, 1968. as in males, the time lapse between initial symptoms and the eatablishment of the correct diagnosis, however, was C 10404 longer in comparison with a series of Wanebo, C. K., Johnson, K. G., Sato, K., males with lung cancer. The neoplasm and Thorslund, T. W. had been observed for periods LUNG CANCai FOLLOWING ATOMIC RADIA- exceeding five years radiologically TION. American Review of Respiratory before the diagnosis was established, Disease 18T3177,11-777-Nov 1968. but these caeee concerned adenocarcinomas, in femalea. The writer arrived at the conclusion that the C 10410 sensitivity of women to the development Kanakami, H. and Ishikawa, S. of lung cancer in connection with KITSUEN TO HAIGAN, RINSHOTEKI TACHIBA smoking ia less than in males also that KARA (SMOKIwr. ...ND LUNG CANCER, FROM the possible diagnosis of lung cancer THE CLINICAL POINT OF VIEW).Nippon is less often entertained for the Rinsho 26(8):1803-7, Aug 1968, differential diagnosis of lung lesions 7-7-w-aplese (Abs.) in women. (Author Abstract)

114 IN C 10419 C 10420 (continued) Takano, K., Osogoshi, K., Kamimura, N., was superior in the treatment group Kande, K., Kane, K., Kamiyama, R., with longer over-all time (5000-6000 Sakamoto, K., Sato. H., Shirai, Y., R/over 40 days) than shorter over-all Set, M., Tanabe. T., Horino, M., time (same dose within 40 days). Minami, Y., Motoji, H., Morita, R., (Author Abstract) Orihata, H., and Hirayama, T. SHOKUDOGAN NO EKIGAKU, TOKU NI ATSUI INSHOKUBUTSU, INSHU, KITSUEN NARABI C 10424 NI MO KETSUBC NI TSUITE. (EPIDEMI- Jackman, R. J., Good, C. A., Clagett, OLOGY OF CANCER OF THE ESOPHAGUS, 0. T., and Woolner, L. B. WITH PARTICULAR REFERENCE TO THE SURVIVAL RATES IN PERIPHERAL EFFECT OF HOT FOOD AND DRINK, BRONCHOGENIC CARCINOMAS UP TO FOUR DRIIKING, SMOKING, AND NUTRITIONAL CENTIMETERS IN DIAMTER PRESENTING AS DEFICIENCIES). Nippon Rinsho 218): SOLITARY PULMONARY NODULES. Journal 1823-8, Aug 1968, Japanese (Abs. of Thoracic and Cardiovascular Surgery 57T1ITT-T,--TailIT6T-- The dietary, drinking, and smoking habits of an experimental population of 200 diagnosed cases of cancer of C 10425 the esophagus were compared with Osburn, H. S. those of a control population of 200 CARCINOMA, SMOKING, AND RHODESIAN people having no disease of the AFRICANS. (Letter) British Medical alimentary tract. The experimental Journal 4(5632):702, MTd, lsa. population composed 167 men, average age 62.6 years, and 33 women, average age 58.9 years. The control popula- C 10430 tion had the same sex ratio and ages Arima, M. within t5 years of the experimental KAN200AN NO EKIGAKU (EPIDEMIOLOGY OF population. The results show that CANCER OF THE LIVER.) Nippon Rinsho the relative risk from smoking alone 26(8):1833-8, Aug 1968, Japanese (Abs.) is less than 1.5, but increases considerably when heavy smoking is The number of cigarettes smoked combined with drinking and ingestion per day was ascertained for 108 cases of hot food and beverages. of primary carinoma of the liver (age and sex not stated) and compared with that for a control population. The C 10420 relative risk of hepatoma without Koga, S. cirrhosis (67 cases), hepatoma with 60 -CO ENKAKU CHIRYOHO NO KENKYU. 32. cirrhosis (99 cases) and cholangioma HAMAN NO HOSHASEN CHIRYO SEISEKI (14 cases) in relation to number of (STUDIES ON TELECOBALT THERAPY. 32. cigarettes smoked is given. In the RADIOTHERAPY OF CANCER OF THE LUNG.) case of cholangioma, the relative

1,27i Igaku Hoshasen Gakkai Zasshi risk is exceptionally high, reaching 8814):4 14711-47, Jul f 8, Japanese 11.4 for smokers of over 30 cigarettes (.) per day. Treatment results of 106 cases of cancer of the lung treated by tele- C 10431 cobalt irradiation during the period Kirikae, I. from 1958 to 1965 were discussed. KOTO GAN NO EKIGAKU NI OKERU. Of these, 74 cases (70 percent were MONDAITEN. (SOME ASPECTS OF THE irradiated more than 5000 R. Ones EPIDEMIOLOGY OF CANCER OF THE two, three, four, and five year LARYNX.) Nippon Rinsho 26(8)11808-11, survival rates of the total cases Were Aug 1968, Japanese s.) 26.4, 10.3, 7.3, 3.9, and 4.9 percent respectively. Survival rates of cases The smoking history, in terms of irradiated more than 5000 R were 31.1, numbers of cigarettes smoked per day, 13.8, 10.0, 5.4 and 6.9 percent was determined for 764 cases of career respectively. Five year relative of the head and neck an 1302 controls. survival rate was 10.0 percent with In the case of male smokers, the standard error of 1.2 percent. No relative risk of larynx cancer was significant difference of results found to be 3.92, of maxilla cancer was seen for five year relative sur- 1.77, of oral cancer 2.04, and of other vival rates of cases between fixed head and neck cancer 1.61. In the field irradiation and moving field case of female smokers, the corresponding irradiation. One year survival rate relative risks were: larynx cancer 6.38,

IT() C 10431 (continued) C 10449 maxilla cancer 0.98, oral cancer 1.12, Madey, J. and other head and neck cancer 1.41. CLINICAL EVALUATION OF 745 CASES OF The relative risk of larynx cancer in PRIMARY LUNG CARCINOMA. Polish females who smoked over 21 cigarettes Medical Journal 7(4):917-777-r968. a day was 19.7: the corresponding relative risk for Hen was 5.1. C 10466 Martens, J. H., Bennett, M. E., and C 10457 Vermund, H. Rigdon, R. H. and Neal, J. RESULTS OF RADIATION THERAPY IN RELATIONSHIP GF LEUKEMIA TO LUNG AND CANCER OF THE LARYNX.Based Upon STOMACH TUMORS IN MICE FED BENZO(a)- Clinical Staging by the International FYRENE. Proceedings of the Society TNM System. An Analysis of 105 Cases. for Experimental Biloq and Medicine Wisconsin Medical Journal 67(12): T35(1J:148 -8, Jan 19 9. 585-95, DeF7067

C 10438 C 10487 de Paula, A. Roumagnoux, J., Durand, J., and CANCER OF THE LUNG. In: Clark, R. L. Gharib, Cl. and Cumley, R. W. (7ditors). The Year SYNDROME DE SCHWARTZ-BARTTER AVEC Book of Cancer, 1967-1968, pp. 110-3. MANIFESTATIONS NEUROPSYCHIQUES AU COURS DE TROIS CANCERS ANAPLASIQUES DU POUMON. (SCHWARTZ-BARTTER C 10439 SYNDROME WITH NEUROPSYCHIC MANIFESTA- Kida, H., Omoto, T., Sakamoto, K, and TIONS IN THREE ANAPLASTIC LUNG CANCERS.) Momose, S. Lyon Medical (35):347 -58, Sep 1968, FUKUOKA KEN HOKUBU NI OKERU SOKO French (Ws.) SHUYO NO EKIGAKU TO INSET. (STATISTICS AND EPIDEMIOLOGY OF URINARY BLADDER Three observations on small cell TUMORS IN NORTHERN FUKUOKA, JAPAN.) anaplastic cancer, complicated by Hifu to Hinye 30(5):883 -9, Oct 1968, psychic disorders due to Schwartz- JapaneseMS.) Bartter syndrome (improper secretion of antidiuretic hormone), were The number of cigarettes smoked presented. In one of the patients, an Per day (N) and duration of smoking antidiuret12 capability was found in the in years (L) were determined for 114 tumor itself, proving that there was cases of urinary bladder cancer (88 an ectopic secretion of a vasopressin- men and 26 women) and 114 controls. like substance responsible for the For both the experimental and the hyponatremla by dilution. The latter control group, the amount of smoking was sensitive only to hydric restric- was classified as follows: Heavy, tion. Knowledge concerning this NxL more than 600, Medium, NxL less syndrome is useful because it some- than 600 and more than 300, Light, times precedes recognition of the NxL less than 300. The results show tumor and can thus aid in its detection. no significant differences between the experimental and control group in the case of men. There is a significant C 10471 difference for women, the relative risk Nanovic, R. being 2.6. RANA DEPISTAZA KARCINOMA BRONHA U ANTITUBERKULOZNIM DISPANZERIMA. (EARLY DIAGNOSIS OF BRONCHIAL CANCER 'C 10443 IN AN ANTITUBERCULOSIS DISPENSARY.) Lekas, M. D. Ttberkuloza 20(3):172-81, May-Jun , MDICAL EXPERIENCES WITH PROJECT HOPE 1968, Serbo-Croatian (Abs.) IN CEYLON. Rhode Island Medical Journal 51(177738717-7127-DFC-1968. The author stressed the i 'nortance of early diagnosis of bronahta carcinoma and discussed diagnostic C 10446 methods emphasizing the importance Modern Medicine. of radiophotography in this field. HYPERCHOLESTEROLEMIA AND LUNG CANCER He cited his own experiences in IN SMOKERS. Modern Medicine :55, diagnosis and alluded to the ability Jan 13, 1969.------cf antituberculosis clinics in making early diagnosis of bronchial carcinoma.

116 I Lo C 10471 (continued) C 10473 (continued) The incidence of bronchial carcinoma of the tumors. Carcinogenic by sex, age groups, occupation and tryptophan metabolites were found in location of habitat, is presented in the urine of heavy smokers which tables. Inhalation of uranium, disappeared after discontinuance of chromium, and arsenic dusts as well smoking. Only 11.3 percent of the as smoking were considered the basic patients were heavy smokers. A factors responsible for the increase hematuria, urination problems, in bronchial carcinoma. occasional urine retention and pain in the kidneys may be symptomatic of bladder tumors and should result in C 10472 prompt urological examination. About Nadj, I. one-third of the patients delayed PO7ODOM ISTOVREMENOG OFSERVIRANJA examination and these individuals had a KARCINOMA BRONHA KOD TRI RODJENA poorer prognosis than those who had an BRATA. (SIMULTANEOUS OBSERVATION ON early diagnosis and prompt treatment. BRONCHIAL CARCINOMA IN THREE BROTHERS). Tuberkuloza 20(3)1182-6, May-Jun 1968, Serbo-Cro:fian (Abs.) C 10480 Kanee, B. Squamous cell bronchial carcinomas ORAL FLORID PAPILLOMATOSIS COMPLICATED were diagnosed in three brothers who BY VERRUCOUS SQUAMOUS CARCINOMA. had been hospitalized during the same Treatment With Methotrexate. Archives Period for suspicion of lung cancer. of Dermatology 99(2):196-202, Feb 1969. In age, they ranged from 58 to 68 years; all had smoked from childhood, two brothers 20-30 cigarettes per C 10500 day and the third 15-20 cigarettes Kleinfeldj M. J. per day. Two other members of the ASBESTOSIS AND NEOPLASIA. Medical same generation of the family also Times 96(12):1223-9, Dec 1967---- had been diagnosed as bearing carcinomas, but in different organs of the body. The author felt that C 10501 this demonstrated the importance of Hathaway, B. M., Copeland, K., and the hereditary role in the development Gurley, J. of the malignant processes, especially GIANT CELL ADENOCARCINOMA OF THE in cases where external factors also LUNG. Report of 21 and Analysis of played a part. It was proposed that 139 Cases. Archives of Surgery prophylatic measures be taken for the 96(0:24-30, Jirirg-69. protection of endangered individuals. C 10508 C 10473 American Cancer Society, Inc. Vahlensieck, W. 1969 CANCER FACTS AND FIGURES. HARNBLASENTUMOREN. (TUMORS OF THE American Cancer Society, Inc., New BLADDER.) Deutsches Medizinishces York, N. Y., 1968, 31 pp. Journal 19(W771f5276, Oct 20, 1968, Gerwan (Abs.) C 10523 Eighty percent of the bladder Perra, L. tumors were classified as fibroepith- LA RADIOTERAPIA DEI TUMORI MALIGNI elial papillomas; the remainder DELLA FACCIA INTERNA DELLA GUANCIA. included epithelial carcinomas (5 (RADIOTHERAPY OF MALIGNANT TUMORS OF percent) and the less frequent THE MUCOSA OF THE CHEEK.)Radiobiologia mesenetymal tumors as secondary Radioterapia e Fisica Medica 23(1)1 bladder tumors.Metastases were 43-51, Jan-PeE TVWftirati (Abs.) present in vessicles, regional lymph nodes and in bones, liver and lungs. Effectiveness of treatment was There was a greater incidence of evaluated in 25 cases of malignant bladder tumors from the fiftieth year neoplasms according to the inter- with a male-female ratio of 4:1.The national T N M system. In age they report discusses the significance of ranged from 33 to 87 years (only 4 the disposition of the uroepitheliun, were women). Twenty-four of the bladder-voiding disorders, exposure carcinomas were of the to occupational carcinogens (chiefly spinocellular type. Thirteen of the aromatic amines), schistosomiasis, cases were treated with interstitial viruses and smoking in the etiology radium therapy, seven with accelerated

117 C 10523 (continued) C 10538 electrons, four with Co-60 irradiation Rigdon, R. H. and one case with contact X-ray CIGARETTE SMOKING AND LUNG CANCER: A therapy. Twenty patients survived CONSIDERATION OF THIS RELATIONSHIP. 1 year, seventeen survived 3 years, Southern Medical Journal 62(2):232-5, fifteen survived 5 years and one Feb 1969. patient survived 9 years after treatment. Twenty-two were smokers: 6 cigarette smokers, 6 cigar smokers C 10541 and 12 reverse smokers (the latter Witz, J.-P., Herdly, J., Miech, O., form of smoking was quite common and Morand, G. among sardinian peasants and shepherds). MODALITES D'ASSOCIATION IRRADIATTM PRE-OPKRATOIRE - CHIRURGIE DANS LE TRAITEMENT DU CANCER DU POUMON. C 10524 (THE MODALITIES OF COMBINED PRE- Farao, O. M., Mosca, A., and OPERATIVE RADIATION THERAPY AND Valentini, S. B. SURGERY IN THE MANAGEMENT OF LUNG RILIEVI CLINICO-STATISTICI SU UN CARCINOMA.)Annales de Chirurgie GRUPPO DI CARCINOMI DEL POLMONE Thoracique etri7M-Visculaire 7(2)1 STUDIATI A LUNGO TERMINE. (SLINICAL 191-4, Apr iT677Prench (Abs.) AND STATISTICAL STUDY OF A GROUP OF PATIENTS AFFLICTED WITH CARCINOMA OF Various modalities in combining THE LUNOS CHECKED AFTER SEVERAL radiation therapy and excision, were YEARS.) Ospedali Chirurgia experimented by the authors since 19(2):97-117, Aug 1968, Italian (Abs.) 1952. In spite of its numerous drawbacks, the conventional radiation The main data collected on the technique gave a statistically basis of a study of case histories of significant improvement in survival. lung carcinoma personally observed, Some recent radiobiological knowledge are reported. 91.03 percent were and headway in the field of high male patients, prevalently in the age energy radiations, have lead the range 50-70, addirted to smoke. In authors to resume, during the last 40 percent of all cases the patient two years, combined radiation and smoked 20-25 cigarets daily. About surgery, an accelerated irradiation 50 percent had been afflicted with with 2,000 to 2,500 rads being ordinary diseases of the respiratory delivered within 5 days immediately tract. The most common symptoms were: prior to excision.The value of such cough, phlegm, thoracic pains, fever, a technique will be estimated in two and loss of weight. Over 50 percent comparable series of irradiated and of the patients were inoperable. not irradiated patients. It already The most frequent causes of inoperability appears certain that the method does were: paralysis of the recurrent not lead to an increase in duration nerve, paralysis of the phrenic nerve, of stay in the hospital or local or lymph node metastases alone, or general operative complications. It associated with other causes. In about is still too early to evaluate late 25 percent the operation was a plain results. (Author Abstract) explorative thoracotomy. Excresis could be carried out in less than 20 percent. The percentage of cases C 10560 inoperable on the basis of clinical Friedell, O. H. and Burney, S. W. criteria increased in proportion to the BLADDER CANCER.AN INCREASING duration of the symptomatology. From PROBLKN. South African Cancer a histologic standpoint, the epidermoid Bulletin a(3)1115-20, J11TZ-eT 1968. type was prevailing. Tha operability rate varied according to the histologic type: it was 50 percent in the C 10E05 epidermoid, 35 percent in the adeno- Schlegel, J. U., Pipkin, 0. E., carcinoma and 27 percent in the Nishimura, R., and DUke, 0. A. indifferentiated type.The survival SNDIES IN THE ETIOLOGY AND PREVENTION rate up to 5 years in all the cases OF BLADDER CARCINOMA. Journal of subjected to excresis was 21.21 percent, Urology 101(3)1317-24, WaFTTE9. increasing up to 35.71 percent if only the lobectomised cases are considered. Considered in toto of all the patients afflicted with lung carcinoma only 4 percent are still living after 5 years. (Author Abstract)

116 C 10606 C 10628 (continued) Bryan, G. T. ROLE OF TRYPTOPHAN METABOLITES The authors report on 404 patients IN URINARY BLADDER CANCER. American with bronchial carcinomas who were treated Industrial HygFgAAssociatiMi------surgically. The preoperative and post- 7=1-3Zoux(111-27-3469. operative aspects of the patient material from 1950 to 1962 (including a statement on the 5-year cure rate) were compared to C 10608 patient material from 1963 to 1967 (in- Shchechkin, V. N. cluding preoperative mediastinoscopy). REPBMW-MHOONECTBIDHE 011YX0114 DOPWAHOO. The rate of exploratory thoracotomies could be decreased to 3.3 percent. 33 PERVICHNO-MNOZHESTVENNYE OPUKHOLI percent of the preoperatively undiagnosed LORORGANOV. (MULTIPLE PRIMARY TUMORS coin lesions were carcinomas. More inten- OF THE OTORHINOLARYNOOLOGICAL ORGANS.) sive screening for carcinomas and inten- Zhurnel Ushnykh NoTryk191 Gorlovykh sive diagnostic efforts for carcinomas in eznei 2815):69- 61, Russian conjunction with improvement of the ritTF7F-- operative conditions at the present time permits expectation of a 33 to 36 percent Only 12 cases of multiple primary 5-year survival late in our patient tumors (from a total pf 489 cases of material (this includes all types and all malignant otorhinolaryngological tumors) surgical methods). (Author Abstract) have been observed by the author. In 10 patients, the tumors appeared successively and in 2 the tumors C 10646 appeared simultaneously. Identical Fortuine, R. histological structures were observed CHARACTERISTICS OF CANCER IN THE ESKIMOS in 5 patients; in the other 7, the OF SOUTHWESTERN ALASKA. Cancer 23(2): tumors had different histological 468-74, Feb 1969. structures. The time of the appearance of the first and second tumors, their treatment and the results were described. C 10652 Two case histories were presented. Kakita, S. TOKYOTOCHO NI OKERU HAIGAN SHUDAN KEN SHIN NO KENKYU. (STUDY OF MASS C 10618 SCREENING FOR LUNG CANCER OF EMYLTEES Jaemin, G. and Cha, J. W. OF TOKYO METROPOLITAN GOVERNMENT. Nippon

RENAL ADENOMAS INDUCED IN RATS BY tchsu Shikkan Oakkai Zasshi 16(11 i DIMETHYLNITROSAMINE.Archives YTIT=6, Nov11511377a7rnrgiTp(Abs. of Pathology 87(3):26777871%11969. Between 1953 and 1966, 93 cases of pulmonary cancer were discovered C 10626 among 838,396 employees of the Tokyo Galera, H., Sanchez, A., Poveda, J., and 141trorolitan Government. These cases Pascual, E. were clinically analyzed in the CARCINOMA BRONQUIOLO. (BRONCHIOLAR present study. (1) The incidence CARCINOMA.) Revista Clinica Espanola of pulmonary cancer was 11.1 per 3(1):71-6, Oct-11,79617-5FEnIsh tAbs.) 100,000.Among 315,142 aged 40 and up, there were 91 cases of A case of a bronchiolar carcinoma lung cancer, the incidence per in a 69-year-old female patient, 100,000 was 0.4 among those under together with the clinical diagnosis and 40, 6.4 among those between 40 autopsy findings, was presented. The and 49, 29.8 among those between lack of a preponderance of males with 50 and 59, and 112.3 among those such tumors indicates that occupational aged 60 and up. (2) An identical exposure and the smoking habit may have group of 45,403 people was studied no decisive influence in its pathology. over 12 years (1953-1964), when the group was reduced to 30,489. Pulmonary cancer was discovered in C 10628 75 persons, and the incidence per Specht, G. and Johst, E. 200,000 was 245.99. (3) A study SIND WIR IN DER OPERATIVEN BEHANDLUNO of pulmonary cancer incidence In DER BRONCHIALKARZINOME VCRANGEKOMMEN? relation to air pollution in terms (HAVE WE MADE ADVANCES IN THE SURGICAL of chimney duet fall pointed to a TREATMENT OP BRONCHIAL CARCINOMAS?) relationship between them. (4) 34 Munchener Mediziniache Wochenschrift percent of the cases of pulmonary 117777491-8, Oct 25, 1965, German cancer discovered were symptomless; Abs.

119 123 C 10652 (continued) C 10693 the others showed such symptom, as Wynder, E. L., Dodo, H., and Barter, coughs, sputum, and bloody sputum. H. R. K. (5) In X-ray pictures, the half of EPIDEMIOLOGY OF CANCER OF THE OVARY. the cases had the coin lesion (16.1 Cancer 23(2) :352 -70, Feb 1969. percent) and nodular type (37.6 percent). (6) Nine cases had been overlooked and misidentified C 10696 respectively. Of 151 cases suspected Cecchini, M. of lung cancer, 55.6 percent had LA MALATTIA PARANEOPLASTICA. pulmonary cancer, the rest had (CoNTRIBUTO CLINICO) (THE PARANE0- Pulmonary tuberculosis (25.2 percent) PLASTIC DISEASES (CLINICAL or other diseases. (7) Of the CONTRIBUTION).) Riforma Medics discovered cases of pulmonary cancer, 82(49:1196-9, Oct 26, 1968, Italian 48.4 percent underwent resection, (Abs. which was radical in 39.8 percent. These cases were divided into three The Author relates two cases of groups: (I) those who had been "paraneocancerous" disease that, in one checked twice a year, (II) those of them, preceded by two years the who had been checked once a year, confirmation of the presence of the and (III) those who had not been primitive tumour at a pulmonary level checked the previous year, or had when clinical subjectivity, objectivity been overlooked or misidentified. and collateral examinations were not in Radical resection was performed in such a way probable ones. (Author 88.9 percent of Group I, 41.2 percent Abstract) of Group II, and 24.2 percent of Group III. (8) 50.0 percent of Group I, 30.7 percent of Group II, and C 10698 25.0 percent of Group III survived Vigliani, E. C., Ghezzi, I., Maranzana, five years after resection. Mass chest P., and Pernis, B. X-ray surveys should be checked EPIDEMIOLOGICAL STUDY OF ASBESTOS twice a year if luhg cancer is to be WORKERS IN NORTHERN ITALY. Medicina discovered at an early stage. del Lavoro 59(8-9)0181-5, Aug-Sep .

C 10683 Callaghan, R. S., Patel, J., and Faber, C 10699 L. P. de Granda, G. O. BRONCHIAL BRUSHING: A NEW TECHNIQUE EL PROBLEMA DEL CANCER. (THE CANCER FOR DIAGNOSIS OF PULMONARY LESIONS. PROBLEM.) Revista Medica de Costa Presbyterian-St. Luke's Hospital Rica 25(412):301-22717171768, Medical BulleTrii 7(3):102-9, Jul 1968. Spanish (Abs.) The influence of carcinogenic C 10686 factors in the evolution of cancers Burkitt, D. P. were reviewed. These factors CANCER EPIDEMIOLOGY IN TROPICAL discussed were heredity, contagion, AFRICA. British Journal of Hospital mutation, oxygen lack, vitamins, Medicine 1(2):214787-g717 T968. viruses, irritation, hemorrhage, tars, parasites, hormones and tobacco. The eonclusions of the American C 10691 Cancer Society and other sources, Cancer. blaming cigarette smoking for the PREOPERATIVE IRRADIATION OF CANCER OF rise in lung cancer mortality, were THE LUNG. Cancer 23(2):419-30, Feb cited. Automobile exhaust fumes were also 1969. held accountable for the rise in cancers of the respiratory tract but nicotine, although very toxic, was C 10692 absolved. The author also cited his Bennett, D. E., Sasser, W. F., and own experiments demonstrating that Ferguson, T. B. Cuban tobaccos were less toxic than ADENOCARCINOMA OF THE LUNG IN MEN. American tobaccos. A Clinicopathologic Study of 100 Cases. Cancer 23(2):431-9, Feb 1969.

120 a4 C 10700 C 10702 (continued) Calvet, J. and Coll, J. RESPIRATORY DISEASES.) Annals of LE CANCER. DANS LES MALADIES Otolaryngology 81:185 -6,7365, PROFES;IMELLES EN OTO-RHINO- French (Abs.) LARYNOOLOGIE. (CANCER IN OCCUPATIONAL DISEASES IN OTORHINOLARYNGOLOGY.) Bronchographic tests have Archives des Maladies Professionnelles indicated similarities between lung de Medecine du Travail erde Securite cancer and chronic nonspecific Sodiale 29(9IT51-67797-gep fgge, respiratory diseases. An unusual YFiEFE(Abs. finding was the presence of a lobar fringe originally observed in patients A high incidence of cancers was with chronic bronchitis and in noted in arsenic, chromium and tubercular patients.The incidence of asbestos workers and in nickel and such fringes in normal individuals cobalt workers. Other metallic however could not be ascertained powders and dusts, by chronic because as was pointed out, individuals irritation, could cause metaplastic, without symptoms do not undergo such epithelial proliferation. Cancers tests. The presence of chronic cough were also noted in pitch, tar and asphalt was considered cause for suspecting workers and in tobacco factory lung cancer. workers. Certain organic chemicals were also singled out as causing occupation-linked cancers. Heat and C 10704 ionizing radiation induced cancers. Touraine, R. and Civatte, J. The combination of tobacco and TUMEUR5 EPITHELIALES MALIONES atmospheric pollution was held (EPITHELIOMAS, CARCINOMES.) responsible for cancers of the nasal (MALIGNANT EPITHELIAL TUMORS passages. Cancers of the larynx could (EPITHELIOMAS, CARCINOMAS).) sometimes be traced to a chronic Revue du Praticien 18(34):5029-30, laryngitis in singers and actors who MC 25, 1968, French (Abs.) abused the larynx. The physical and chemical factors in the development of malignant tumors C 10701 were discussed briefly. Physical Charpin, J., Aubert, J., and Longefait, factors included mechanical injury, H. burns (spinocellular epitheliomas FIBROME DU POUMON. (FIBROMA OF THE from cigarette burns), exposure to LUNG.) Marseille Medical 105(10)1 sunlight, and ionizing radiation. 779-81, 1968, French (Abs.) Chemical factors included tar and tar derivatives (scrotal cancers in Diagnosis of an opacity in the chimney sweeps, now rare), arsenic and lower right lobe of the lung of a compounds of tin, cobalt, nickel, and 39-year-old man has been made. The beryllium. The text was only a small tumor was similar to several other portion of a large chapter on skin soft tumor masses previously excised tumors, both malignant and benign. from the left shoulder of the man and identified as benign fibromas. Benignity of the lung tumor was C 10710 established on the basis of a Scanlon, P. W., Soule, E. H., Devine, histological examination by taking K. D., and McBean, J. B. into account the limitation of the CANCER OF THE BASE OF THE TONGUE. tumor, absence of mitoses or nuclear American Journal of Roent enolo anomalies and of collagenic differen- Radium Therapy an uc ear e c ne tiation. The discussion was also 105(1)s26 -36, Jan 19637--- concerned with the possibility of the tumor being a fibrosarcoma of slow evolution. The man had been identified C 10713 in the report as having smoked 30 Tucker, B. L. cigarettes per day. INTERNATIONAL CANCER CENTRE, NEYYOOR, SOUTH INDIA. Radiography 35(409):19-22, Jan 1969. C 10702 Huizinga, E., Orie, N. O. M., and Van der Mal, A. M. C 10715 CANCER DU POUMON ET AFFECTIONS Spratt, J. S., Jr. RESPIRATOIRES CKRONIQUES ASPECIFIQUES. CANCER DETECTION: CURABILITY OF (LUNG CANCFA AND NONSPECIFIC CHRONIC SYMPTOMATIC AND ADVANCED CANCER. Cancer Bulletin 21:7-14, Jan-Feb 1969.

Iii Il5 C 10726 Ochaner, A. C 10802 (continued) LUNG CANCER--RECENT ADVANCES iN DIAONOSIS function explained by immunocompetent AND TREATMENT. Industrial Medicine and cellular elements compared both with the staltm 38(2):49-52, Feb 19g77----- leukoplasic alteration and the cancer. One fact which tends to demonstrate the possible correlation of carcinogenic C 10733 substances contained in tobacco and the Macbeth, R. development of epithelial tumors in THE TREATMENT OF CARCINOMA OF THE general is given to us in the observation HYPOPHARYNX: THE GUTTER-GRAFT OPERATION. in the same casuietics of a great majority Journa111l ofLaryngolo969.gy and Otology of patients consuming large quantities of 8=): 7. 5, Fib 1 tobacco for the most part dealing with subjects who expose the mouth to the direct action of juice by the chewing of C 10750 the leaves. In another group of 55 Cady, B. and Catlin, D. patients with oral localization of EPIDERMOID CARCINOMA OF THE GUM. spinocellular carcinoma there were Cancer 23(3)1561-69, Mar 1969. epitheliomas even in the lips, larynx and esophagus; in these patients were found the maximum incidence of multifocal C 10763 lesions. Valaitis, J., Mcdrew, E. A., Chomet, B., Correll, N., and Head, J. BRONCHOOENIC CARCINOMA IN SITU IN C 10813 ASYMPTOMATIC HIGH-RISK POPULATION OF Weigensberg, I. J. and Raventos, A. SMOKERS. Journal of Thoracic and CLINICAL CLASSIFICATION OF CARCINOMA CardiovaecUrf7-.usserr,T7r3)T,0732. OF THE LUNG. Missouri Medicine 66(1): Mar 1969. 31-6, Jan 1969.

C 10772 C 10815 Pennsylvania Pharmacist. Rangan, S. R. S., Mukherjee, A. L., CANCER ASSOCIATED WITH CHROMOSOME and Bang, F. B. IMBALANCE. Pennsylvania Pharmacist SEARCH FOR AN ADENOVIRUS ETIOLOGY 50(7):30, Fer1969. OF HUMAN ORAL AND PHARYNGEAL TUMORS. International Journal of Cancer 3C6)1814-28, NUV7571334. C 10773 Hoopes, J. E., Wolfort, F. G., and Wilkins, G. W. C 10820 FIVE-YEAR RESULTS FROM TREATMENT Kennedy, J. H., Coyne, N., and OF CANCER OF THE TONGUE. Plastic Khairallah, P. and Reconstructive Surgery 43 CARCINOMATOUS NEUROENDOCRINOPATHY 777 -07, Mar 1969. ASSOCIATED WITH CANCER OF THE LUNG. Journal of Thoracic and Cardiovasc4lar uFgilg 37(2J:276-837-Feb 1969. C 10802 Scevola, A. LA LEUCOPLACHIA LINGUALE NEL QUADRO C 10823 DELLO SVILUPPO CARCINOMATOSO Canadian Medical Association Journal. MULTICENTRICO. (LINGUAL LEUKOPLAKIA THE LUNG. Canadian Medical Association IN MULTIFOCAL CARCINOMATOUS DEVELOP- Journal 100(7)1349 -517Per15, 1969. MENT.) L'Oto-Rino-Laringologia Italiana 37r211107-20, Mar-Apr 1966, TTWITIF(Abe. C 10830 Concours Medical. The Author deals with the problem TABAC: POUR QUELQUES PlCOGRAMMES DE of the plurifocal development of the TROP.... (TOBACCO: FOR SOME PICOGRAMS leukoplasic alteration at the level of TOO MANY---.) Concours Medical 90(52) the lingual mucous membrane reporting :8999, Dec 28, 1968, French -(Abs.) 12 observations of this type in which in 2 thare was concomitant the presence Doctors may soon have a simple test of an intraepithelialcarcinoma or eo for determining which heavy smokers are called in situ'. After having amply faced with cancer by approaching the reported the bibliographical newt: threshold of 2.2 picograms of a clorant. existing on this subject, some medical Basis for the test was the observation reports are discussed for the possible that buccal epithelial cells retain

122 I a (0 C 10850 (continued) C 10830 (continued) increasing quantities of acriflavine direct relationship to the smoking habit and the manner and amount of tobacco with the rise in DNA content. D. Roth's test permits measurement of the colorant consumed. retained by the cell, expressed in picograms. For 24 subjects with cancer of the buccal cavity, the content was C 10852 Schievelbein, H. and Zickgraf, Th. between 2.3 and 4 picograms, between TUMOREN DER HARNBLASE. (BLADDER 0.6 and 2.3 for 92 nonsmokers, and between 1.4 and 3.3 for 74 heavy TUMORS.) In: Schievelbein, H. (Editor). Nikntin: Phermakologie und Toxikologie smokers (more than 30 cigarettes per des Tabakrauches. The rate decreased slowly when Stuttgart (West day). Germany), Georg Thieme Verlag, 1968, the subject stopped smoking, normalizing pp., 242-9., German (Abs.) in about 6 months.The rise in DNA was of increased synthesis seen as evidence More smokers than nonsmokers were and a sign that the cell was near mutation as a result of tobacco irrita- represented in subjects with bladder carcinomas as evidenced by prospective tion. and retrospective epidemiological investigations. The correlation was greater with higher consumpn.ion of C 10849 cigarette smoking and with inhaling. Franz, C. R. and Wey, W. With minor exceptions, no auch correla- OBERE LUFT- UND SPEISEWEGE. (b°PER RESPIRATORY- AND ALIMENTARY TRACT.) tion wag observed with pipe or cigar In: Schievelbein, H. (Editor). Nikotin: smokers. Mortality risks for all Pharmakologie und Toxikologie des smokers wts 2 to 3 ti.aes greater than Stuttgart (West Germany), for nonsmokers. Mortality due to Tabakrauches. bladder cancer was only 2 to 4 per Georg Thieme Verlag, 1968, pp. 199-205., 100,000 (compared to 30-70 for lung German (Abs.) cancer) and a possible relationship could only be suspected. Various authors Carcinogenic and noncarcinogenic effects of tobacco on the mucosa of the have recognized intermediate products of upper respiratory- and alimentary tract tryptophan metabolism as the cause of The noncarcinogenic experimental and clinical bladder cancers. were reviewed. A resent study on 6 subjects indicated effects included chronic hyperplastic inflammation of the mucous membrane, that tobacco smoke constituents might influence tryptophan metabolism but was leukoplakia and "smokers larynx." The carcinogenic effects dealt with the not definitely proved since excretion of tryptophan metabolites varied so widely nasal and secondary nasal cavities, mouth cavity, and the pharynx and in normal subjects. larynx. C 10855 Schievelbein, H. C 10850 GASTROINTESTINALTRAKT. (GASTROINTESTINAL Gsell, O. TRACT.) In: Schievelbein, H. (Editor). BRONCHIALKARZINOM. (BRONCHIAL ::-ARCINOMA.) In: Schievelbein, H. (Editor). Nikotin: Nikotin: Pharmakologie und Toxikologie Pharmakologie und Toxikologie des des Tabakrauches. Stuttgart (West Germany), Georg Thieme Verlag, 1968, pp. Tabakrauches. Stuttgart (West Germany), Georg Thieme Verlag, 1968, pp. 206-29., 261-6., German (Abs.) German (mbs.) The pharmacological action of nico- The relationship between smoking and tine and smoking on the gast:ointestinal Certain clinical bronchial carcinoma was reviewed. Mor- tract was reviewed. bidity and mortality statistics were pre- effects or smoking varied from individual sented in tables and graphs showing the to individual, as for example, intestinal incidence of such cancers in Germany and passage and motility, which were Switzerland (countries where accurate accelerated in some and retarded !r: records are maintained) according to age, others. Stomach and duodenal peptic sex, geographical location whether urban ulcers were more frequent in cigarette smokers than in nonsmokers or pipe and or rural and smoking habits. The role or air pollution and other exogenous cigar smokers. Chronic strophic gastri- factors, and influences such as tis appeared to be unfavorably influenced genetic, psychological and religious, by smoking. ro causal relationship was observed bctw2en smoking and morbidity were also dealt with. All investigations showed that in middle age up to 70 years and mortality due to ulcers but .moking in the last 4 decades, there was an was not recommended by :cost authors enormous increase in epithelial bronchial during active growth of the ulcers. Esophageal carcinomas were unfavorably carcinoma and its earlier stages In i I12 C 10855 C 10910 (continued) Blair, A. E. influenced by cigarette smoking. The Oral relationship between stomach carcinomas THE GENESIS OF A CARCINOMA. SurFery, Oral Medicine and Orri-- and smoking was not statistically signifi- PathoImi-r7r4):433-40,-ITF1-9-69. cant. In explanation of the mechanism of action of smoking upon the gastrointestinal tract, it was conjectured that C 10914 a harmful action might be exerted by hydrocyanic acid, liberated from saliva- Jones, D. G. and Gabriel, C. E. swallowed thiocyanate by the hydrochloric THE INCIDENCE OF CARCINOMA OF THE LARYNX acid cf the stomach. IN PERSONS UNDER TWENTY YEARS OF AGE. Laryngoscope 79(2):251-5, Feb 1969.

C 10663 Watne, A. L. C 10917 DISORDERS OF THE MOUTH (MALIGNANT). Hinds, J. R. and Hitchcock, G. C. Current Therapy :623-7, 1969. ADENOCARCINOMA OF THE LUNG. Thorax 24(1):10-7, Jan 1969.

C 10866 Ochsner, A. C 10921 CARCINOMA 0? THE LUNG. Current Therapy Heart Research Newsletter. :116-7, 1969. ELEVATED CHOLESTEROL MAY INCREASE LUNG CANCER RISK IN SMOKERS. Heart Research Newsletter 13(4)s2, Winter 1969. C 10881 Walike, J. W. TUBE FEEDING SYNDROME IN HEAD AND C 10925 Wellmann, K. F., Chafiian, Y., and NECK SURGERY. Archives of Otolaryngology Edelman, E. 89(3):533-6, Mar 1969. SMALL BOWEL PERFORATION FROM SOLITARY METASTASIS OF CLINICALLY UNDETECTED C 10889 PULMONARY GIANT CELL CARCINOMA.American Ross, W. L., Hayes, R. L., and Kuttner, Journal of Gastroenterology 51(2):145-50, D. H. Feb 1969. STOP ORAL CANCER.Modern Medicine :111-5, Apr 7, 1969. C 10930 Berndt, H., Wildner, G. P., and Klein, K. REGIONAL AND SOCIAL DIFFERENCES IN CANCER C 10896 Sayenko, A. J. INCIDENCE OF THE DIGESTIVE TRACT IN THE A METHOD FOR STUDYING MORBIDITY FROM GERMAN DEMOCRATIC REPUBLIC. Neoplasm PRECANCEROUS CONDITIONS AND THE QUESTION 15(5):501-15, 1968. AS TO FREQUENCY OF THEIR OCCURRENCE ON THE TERRITORY OF THE KIRGHIZ SOVIET SOCIALIST REPUBLIC. Neoplasma 15(5):565- C 10939 71, 1968. Vadura, F. DEVELOPMENT OF CANCER MORBIDITY AND MORTALITY IN CZECHOSLOVAKIA. NeoPlasma C 10897 15(5):475-84, 1968. Chaklin, A. V. ORGANIZATION OF STUDIES OF THE EPIDEMIO- LOGY OF MALIGNANT TUMORS. Neoplasma C 10945 15(5):549-57, 1968. Concours Medical. POUR LES REINS, LA PIPE EST PLUS DANOEREUSE QUE LA CIGARETTE. C 10898 (THE PIPE IS MORE DANGEROUS THAN Messert, B. and Blume, W. T. THE CIGARETTE FOR TPE KIDNEYS.) PARENCHYMATOUS CEREBELLAR DEGENERATION Concours Medical 99(46i:7639, Nov ASSOCIATED WITH CARCINOMA OF THE LUNG. 16, 1968, Prent W (Abs. Wisconsin Medical Journal 68W:101-7, A retrospective study by J. Bennington FerITO7 and F. Laubscher on 88 patients (92 percent smokers) and 9c conrols (75 percent smokers) showed that the risk of renal C 10909 adenocarcinoma was 5.] times greater for Wunder, R. those .cooking more than 10 cigarettes A DEMOGRAPHIC VIEW ON THE OCCURRENCE OF daily, 10.3 times greater for pipe MALIGNANT NEOPLASM IN THE POPULATICN. smokers, and 12.9 times gi%ater for Neoplasm 15(5):485-500, 1968.

124 es C 10945 (continued) C 11006 (continued) cigar smokers. Thus smokers who inhaled elimination of professional cancer and suffered less than those who swallowed also the reduction of cancer of the tobacco Juice, sucked on a pipe or chewed stomach show that legislative measures on cigars. In experiments on rats, may be of evident success. Cancer of the dimethylnitrosamine administered buccally stomach has decreased by nearly 50 was more effective in inducing renal percent in the last 30 years, mainly as adenocarcinoma than when inhaled. a consequence of the elimination of formerly used chemical heterogeneous suttances, which were added to the C 10968 food. That the psychological proposi- Bhaskar Rao, P. A. tion for en active cancer-prophylaAls A CASE OF BRONCHOGENIC CARCINOMA. are not yet fulfilled, is proven by the Mediscope 11(0:349-51, Nov 1968. continued increase of cancer of the lungs. It is caused by the still increasing tobacco consumption and C 10980 also partly by air-pollution. To Bergman, F. solve the problem of cancer by any TUMORS OF THE MINOR SALIVARY GLANDS. possibility it needs not only the Cancer 23(3):538-43, Mar 1969. further completion of practical cancer- cootrol and base-research in the cancer field, but, above all, a C 10981 reformation of the daily customs of Silber, I., Bowles, W. T., and life. Otherwise cancer will become Cordonnier, J. J. the third great menace of the future PALLIATIVE TREATMENT OF CARCINOMA OF THE of man, besides the danger of a URINARY BLADDER.Cancer 23(3):586-8, Mar threatening explosion cf the popula- 1969. tion and the danger of a shifting of the races in disfavor of the "white man". C 10983 Golub, G. R. and Lefemine, A. A. MULTIPLE MALIGNANCIES IN LYMPHO- C 11008 PROLIFERATIVE DISORDERS DIAGNOSED BY Lee, B. C., and Jepsen, O. NEEDLE ASPIRATION BIOPSY OF PULMONARY KIKANSHISEI HAIGAN NI TAISURU LESIONS. Cancer 23(3):725-9, Mar 1969. JUKAKUKYOKENSA 647 REI NO RINSHO LIKEN (MEDIASTINOSCOPY IN BRONCHOGENIC CARCIN- OMA. CLINICAL EXPERIENCE WITH 647 CASES.) C 10994 Jibi Inkoka 41(1):41-4, Jan 1969, Lalstela, E., Koivunieml, A., and JapariFieTAbs.) Sillanpaa, V. OBSERVATIONS ON 190 SOLELY CYTOLOGICALLY The application of mediastinoscopy to VERIFIED CASES OF BRONCHOGENIC CARCINOMA. 647 cases of bronchogenic carcinoma, not Scandinavian Journal of Thoracic and amenable to surgical exploration, gave Cardiovascular Surgery 2(2):997-1-04, 1968. positive biopsies in 214 or 33 percent of the cases. Of tne 647 cases, positive biopsies were found in 87 or 23 percent C 11002 of 380 patients with squamous cell carcin- Sobin, L. H. omas, 95 or 57 percent of 167 patients CANCER IN AFGHANISTAN. Cancer 23(3): with anaplastic cPrcinomas, 27 or 43 676-68, Mar 1969. percent of 63 patients with adenocarcinomas, and 5 or 19 percent of 37 patients with other types of tumor. No mention is C 11006 made of smoking history. Bauer, K-H. VOM KREBSP4OBLEM-HEUTE UPiD MORGEN. (THE CANCER PROBLEM-TODAY AND TCMORROW.) C 11009 In: Arbeitsgemeinschaft 2ur Forschung Yagi, M., Masuda, S., Kawaguchi, Y., des Landes Nordrhein-Westfalen. Natur-, Okamoto, Y., and Hirayama, M. Ingenieur- and Gesellschaftwissenschaften, JAKUNENKI AKUSEI SHUYO NO TOKEITEKI No. 174. Koln and Opladen, Westdeutscher KOSATSU (STATISTICAL INQUIRY INTO Verlag GribH, 1968, 74 pp, German (Abs.) MALIGNANT TUMORS IN YOUNG PEOPLE.) Jibi Inkoka 41(1):45-8, Jan 1969, Japanese By extrapolating the curves of (Abs.) today, we must realise, that :_oon after the year 2000 every 4th man will succumb Over the past 10 Years, 562 cases of to cancer. So cancer-prophylaxis is of cancer of the ear, nose, and throat have increasing impeatance. The impressive been seen at The Otolaryngology Depart-

125 1 49 C 11009 (continued) C 11048 (continued) merit of The Kyoto Municipal Medical on the basis of etiological considera- School in Japan. A statistical break- tions. Developed from descriptive down is given of these cases by age, epidemiology, statistical graphs are site, and type of cancer. One outstand- presented for Norway on the rate of ing finding from this analysis is that incidence of cancer of the thyroid, in your people age 19 and under, the stomach, lip, and breast in relation to site of the cancer is more likely to be calendar years, sex, and geographical in the nasopharynx whereas in adults age provinces. These data are evaluated on 20 and over, it is more likely to be in the basis of analytical epidemiology. the larynx or maxilla. No mention is Retrospectively, statistics are derived made of smoking history. which show a causal association and therefore forecasts can be made of the rate of future occurrence. The effects C 11016 of smoking and exposure to radiation, as Thiede, T. and Christensen, B. Chr. well as the significance of cancer-prone BLADDER TUMOURS INDUCED BY CHLORNAPH- occupations can be evaluated in the same AZINE. Acta Medica Scandinavica 185 way that the effect of smoking in workers (1-0:133=77 Jan-Feb 1969. in the rubber and gas industries can be established.

C 11021 Pindborg, J. J., Mehta, F. S., Gupta, C 11051 P. C., and Daftary, D. K. Wisniowska, J. PREVALENCE OF ORAL SUBMITCOUS FIBROSIS NALCO PALENIA TYTONIU A RAK DROG AMONG 50,915 INDIAN VILLAGERS. ODDECHOWYCH. (THE HARMFUL SMOKING HABIT British Journal of Cancer 22(4):646-54, AND CANCER OF THE RESPIRATORY TRACT.) Dec 1988. Otola olo is Polska 22(5)053-8, 1968, Pot S A s.

C 11041 A literature review of 28 references Horacek, J. is presented to illustrate the link DER JOACHIMSTALER LUNGENKREBS NACH DEM between smoking and cancers related to ZWEITEN WELTKRIEG (BERICHT UBER 55 respiratory passages. Of some 500 FALLE.) (THE LUNG-CANCER OF JOACEIMSTAL chemical agents known to be carcinogenic, AFTER THE SECOND WORLD-WAR. A REPORT OF three occurring in tobacco smoke are 55 CASES.) Zeitschrift fur cited: 1,2,5,6-dibenzanthracenel 3,4- Krebsforschung 721):5247-1969, German benzopyrene; and 9,10-dimethy1-12-benz- (Abs.) anthracene. These often act as initiat- ing carcinogens, or precursIrs to the The autopsy records of the hospital in formation of cancer cells. Later the Karlsbad contain 16 cases of lung cancer cancer and its metastases may develop of workers from the uranium-mines of under the action of quite different Joachimstal who died during the second agents even after the patient may cease world war (head of the department Dr. smoking. This explains why autopsy Kudlich), and 18 cases from the post-war - reports are at times contradictory. period up to 1961 (see Tab.7). Between While cancerous changes of the trachea 1962 and 1966, 55 cases of lung-cancer and bronchi were found more frequently from Joachimstal were autopsied. Com- in smokers, there is no strict correla- pared with the previous cases of Sikl the tion between this incidence and whether shorter tixe of exposition (50 percent or not the person, when living, '4as a under 11 years v. one single case) and a nonsmoker, or a light-, medium-, or heavy higher percentage of small cell carcinoma smoker. The chemical agent exerts its p0 v. 57 percent) is remarkable. influence initially, but is accompaniel (Author Abstract). by a mechanical action which causes an injury and/or helps to propagate the chemical agent or agents. C 11048 Pedersen, E. EPIDEMIOLOGISK CANCERFORSKNING. C 11053 (EPIDEMIOLOGICAL CANCER RESEARCH.) Fernstrom, R. Tidsskrift for den Norake CANCER OCH CANCERFRAMKALLANDE FAKTORER. Laegeforening 6311.2b)31166-73, 1968, (CANCER AND CANCER-CAUSING FACTORS. Norwegian labs.) Svensk Farmaceutisk Tidskrift 72(26 903-12, Oct 30, 1968, Swedish (Abs. Epidemiological cancer research in the Scandinavian countries is undertaken

126 C 11063 (continued) C 11087 Tale, P., garaste, K., and Meanies, T. I. A normal cell is illustrated and a BRONCHIOLO-ALVEOLAR CELL CARCINOMA OF rather complete cytology given, along THE LUNG. Annales Chirurgiae et with details of nucleic acids and protein GynaecologiirMiaae 571-0468,792, 1968. synthesis. The normal growth of both health and abnormal cells is discussed briefly.After mentioning Galen'a opin- C 11090 ion that 'cancer is due to an excess of Sisson, G. A. and Goldstein, J. C. black bile liquor', an opinion remaining INTRAORAL CARCINOMA.Archives of unchanged for 1000 years, some cancer- Otolaryngology 89(4):646-51, Apr1969. causative factors are outlined. These are listed as: hereditary factors, external influences, and carcinogens, which C 11091 are treated as chemical carcinogens and Trible, W. M. and Kahaner, H. as viruses and related causative agents. CANCER OF THE LARYNX AND PHARYNX. A tumor cytology is outlined, and Archives of Otolaryngology 89(4)1617-9, methods to cure or alleviate cancer are Awrem. cited. These methods may include the administration of cytostatic agents leading to chromosome aberrations, and/or C 11095 treatment with X-rays to attack the DNA - Medical News. synthesis. HIGH RATE OF ORAL CANCER. Medical News (33:0:5, Feb 21, 1969.

C 11066 Sano, L., and Kaneko, M. C 11101 SAIKIN 7 NENKAN NI KOKURITSU TOKYO Andersen, I.B., Noring, O., and Sorensen, DAI-ICHI BYOIN NI NYUIN SHITA KAN KOHEN B. NI TSUITE (CASE OF CIRRHOSIS OF THE LIVER LUNG CANCER. Danish Medical Bulletin ADMITTED TO THE FIRST TOKYO NATIONAL 16(2)158-72, Fir-g69. HOSPITAL DURING THE PAST SEVEN YEARS.) Iryo 22(11)11296-306, Nov 1968, Japanese 11174.) C 11108 Hornberger, H. R. In the period 1960-67, 26 cases of THOUGHTS ON LUNG CANCER IN MAINE. cirrhosis of the liver were admitted to (Editorial Journal of the Maine the First Tokyo National Hospital. Of the MedicalAss)ocTITI7F767377r5=r7Mer 1969. 26 cases, 14 had also primary cancer of the liver. The patients' age at death ranged from 15 months to 84 years, with C 11113 the modal range in the fiftie's for Rao, L. G. S. and Brown, R. I. F. cases of cirrhosis without cancer. The HUMAN EMOTIONS AND CHEST ILLNESS.Health modal age range was from forty to the 5(5):144-7, Oct 1968. sixties in casea with cancer. Seventeen or 67 percent of the cases had a history of drinking. No mention is made of smok- C 11115 ing history. Cox, C. E., Cass, A. S., and Boyce, W. H. BLADDER CANCER:A 26-YEAR REVIEW. Journal of Urology 101(4):550-8, Apr 1969. C 11078 Svoboda, V. AN ANALYSIS OF SOME POSSIBLE EPIDEMIO- C 11116 LOGICAL FACTORS INVOLVED ItCARCINOMA OF Food and Cosmetics Toxicology. THE LARYNX. Neoplasms 15(6)1677 -e4, CARCINOGEN TESTING IN THE NEW-BORN MOUSE. 1968. Food and Cosmetics Toxicology 6(5): 633=1 reC 1968. C 11083 Huth, T. C 11123 PRE- INTRA- AND POST-OPERATIVE CARE OF Cooke, R. A. THE LUNG CANCER PATIENT. Journal of CIRRHOSIS AND HEPATOMA. Pa ua and New the Kentucky Medical AssocTrUBF-t7TM Guin0 ea Medical Journal liturr-ra7 REF IlTr-t, mar 19617--- IT

127 C 11124 C 11219 Food and Cosmetics Toxicology. Ceballos Uriarte, A. M. and Risemberg, A. GETTING TO GRIPS WITH ASBESTOS.Food DIAGNOSTICO DIFERENCIAL DEL CANCER DE and Cosmetics Toxicology 6(5):657777- PULMON Y NEUMOPATIAS AGUDAS. 54F (DIFFERENTIAL DIAGNOSIS OF LUNG CANCE1 AND ACUTE FNEUM0PATHIES.)Revista de la Facultad Ciencias Medium C 11126 7B(7:201-77 Apr-Jun 1968, Spanish (Abs.) Higglnson, J. PATTERN OF CANCER IN INDUSTRIALIZED AND The clinical symptoms shown by 169 NON-INDUSTRIALIZED COMMUNITIES. Food patients is analyzed.These patients and Cosmetics Toxicology 6W:5657- were admitted to an Infectious Disease 176 P36117 Service during the period 1951-1966 under the intial assumptions of acute and subacute pneumopa thies, rheumatism, C 11128 neuritis, etc., but in every case the MacMahon, B. final diagnosis wax pulmonary neoplasia. EPIDEMIOLO01C ASPECTS OF CANCER. CA The most usual guiding symptoms such as 19(1):27-35, Jan-Feb 2969. loss of weight, bleeding expectorations and thoracic pains, specially in the case of heavy smokers are evaluated. The C 11142 necessity to apply the most important Public Health Reports. techniques for an early and correct DENTISTS TO ALERT PATIENTS WHO SMOKE TO diagnosis is also evaluated. (Author CANCER RISK. Pu....11c Health Reports Abstract) 84(3):244-5, Marl 9. C 11225 C 11151 Veys, C. A. European Journal of Cancer. AETIOLOGY OF TUMOURS OF THE URINARY CIGARETTE SMOKING. European Journal of BLADDER.Urologia Internationalis Cancer 5(1):81-2, Feb 1969. 24(3):276-B8,

C 11213 0 11246 Aubertin, E. Shamberger, R. J. and Frost, D. V. TABAC ET CANCER DU LARYNX. (TOBACCO AND POSSIBLE PROTECTIVE EFFECT OF CANCER OF THE LARYNX.)Bordeaux Medical SELENIUM AGAINST HUMAN CANCEh. 1(10):1990, Oct 1968, Fri:7E777877-- Canadian Medical Association TFUFFIFT116Urrt7Tt2, Apr 12, 1969. The author in a letter to the journal referred to the concurrence in 1946 of a number of O.R.L. specialists with the C 11252 statement that tobacco favored the appear- Tennekoon, G. E. and Bartlett, G. C. ance of cancer or the larynx.He also EFFECT OF BETEL CHEWING ON THE ORAL summarized the more recent statistics MUCOSA. British Journal of Cancer, of J. Terracol, J. Calvet, P. Marques, and 23(1):39-T371REF 1-03b77 J. Coll concerning a Joint investigation of Toulouse and Montpelier of 980 cases of cancer of the larynx. Of this number 861 C 11257 were heavy smokers (2 or more packs per Nakajlma, M., Otsuki, K., Kato, A., day) and moderate smokers (10 to 20 ciga- Katie, S., Tsukushi, S., Nakajima, T., rettes per day. The percentage of smokers Nishimura, M., Fuk-uda, T., Home, H., was 88 percent. If light smokers (4 to 5 Matsumoto, M., and Yoshiba, A. cigarettes per day) were added the per- AKUSEI SHUYO NO KENKYU. VII. 5-NEN centage rises to 98 percent. Guns of SEIZONREI NO KENTO. (RESEARCH ON Louvain and Portmann of Bordeaux have MALIGNANT TUMORS. VII. STUDY OF stated that all the subjects with cancer 5-YEAR SURVIVAL CASES.)Kyosai of the larynx that they have observed were Iho 17(2):4, 29-33, Spring-1968, heavy smokers. Of the 980 subjects cited 7W-Fanese (Abs.) above, 961 were men and only 19 were women. Twelve of the 19 had not smoked A br1akdown is given by age, sex, and Indicating that a hormonal factor probably site of cancer, of the 5-year survival Intervened. Early experiments on the rates of patients receiving treatment in carcinogenic action of tobacco tar and the the Toranomon Hospital, Tokyo, during the Irritating effect of tobacco smoke on the period 1958-1962. Of the 60 male patients mucosa wera also mentioned. with lung cancer, 2 or 3.3 percent were 5-year survivors.None of the 15

128 C 11267 (continued) C 11346 female patients with lung cancer survived Clemmesen, J. 5 years. ON THE EPIDEMIOLOGY OF RESPIRATORY DISEASES. (Editorial) Scandinavian Journal of Respiratory D seases C 11272 FOTT177273, 1969. Horak, J. VEDECKE PODKLADY SKODLIVOSTI KOURENI. Kriticky Referat. (SCIENTIFICEVIDENCE C 11350 ONTHE ADVERSE EFFECT OF THE SMOKING Kerbrat, 0., Dincuff, P., Simonot, 0., HABIT. A Critical Review.)Vnitrni Mollaret, J., and Coat, P. Lekaratvi 15(3)2269-82, 1969 CirEE-TAbs.) EPITHELIOMA ALVEOLAIRE, DIT ENCORE "ADENOMATOSE PULMONAIRE". (ALVEOLAR The paper presents a critical review EPITHELIOMA, STILL CALLED "PULMONARY compiled from data in the literature cn ADENOMATOSIS".) Ouest-Medical 21(23): the adverse effect of the smoking habit 1589-93, Dec 10, nur e,r7(Abs.) on diseases of the respiratory, circulatory and digestive systems. particular A case of a 52-year-old woven who attention was devoted to the tnterrela was hospitalized for respiratory tionship between smoking and the origin insufficiency and a degeneration of her of lung cancer.Briefly mentioned was general condition was reported.The the effect of smoking on cancer of the patient died approximately six months urinary bladder and kidneys, on blood after the first symptoms. Details of coagulation, the blood level of vitamin the examinations were given; the C and the cell as such. In lonclusion, histological examination confirmed the the effect of smoking on longevity and diagnosis of primary alveolar cancer. mortality were discussed. (Author No association with tobacco waa reported. Abstract) The author also discussed the arguments concerning the nomenclature and malignity of the tumor. C 11279 Greco, S., Pastorelli, S., Ferranti, G., Benatti, O., end Dall'Oglio, D. C 11352 TUMORI MALIGN' WI DEL PoLMONE: Alonso, J. M. SARCOMA, CARCINOSARCOMA E LEIOMIOSARCOMA. MESA REDONDA SOBRE EL CANCER LARINGEO (RARE MALIGNANT TUMORS OF THE LUNG: EN LA MUJER, DEL COMTE LATINOAMERICANO SARCOMA, CARCINOSARCOMA AND LEIONYOSAR- PARA EL ESTUDIO DEL CANCER LARINGEO. COMA.) Rivista di Patologia e Clinica (ROUND TABLE ON LARYNGEAL CANCER IN della Tu5:6763178T-4107:606-2r,11187- WOMEN, FROM THE LATIN-AMERICAN COMMITTEE Minn (Abs.) FOR THE STUDY OF LARYNGEAL CANCER.) Acta oto-Rino-Laringologica Ibero-Americana Four rarely observed cases of primal-, Tr57476:17,-731117-33FhilE-115177----- pulmonary neoplastic lesions, consisting of 2 sarcomas, a carcinosarcoma, and The incidence of laryngeal cancers a malignant leiomyoma were reported. by age and sex in several Latin-American The principal clinical anatomohisto- countries was reported in this summary logical and evolutive aspects of such of the proceedings of the Committee.It lesions were discussed. Two of the was concluded that laryngeal cancer in subjects were identified as moderate women is leas malignant than in men and smokers, another had smoked 20-25 more or less curable both by radiation cigarettes per day, and the fourth was and surgery, which is partly explained a nonsmoker. by its graater localization in the glottis. Hypopharyngeal cancer is relatively less frequent in women and C 11295 does not appear to be more benign or Ondok, J. and Svoboda, V. more easily curable than in men) it STATISTICAL ANALYSIS CONCERNING THE should be treated bj surgery followed OC,URRENCE OF MALIGNANT TUMOURS IN by radiation or in reverse order.The THE DISTRICT OF CESKE BUDEJOVICE wide-spread use of tobacco can be an DURINO THE PERIOD 1957-1966. important factor in the observed increase Neoplasma 16(1)289-99, 1969. in the number of laryngeal cancers in women.

129 /33 C 11356 C 11377 piaget, F. and Gros, J.-C. Russo, C. LOCABIOTAL PRESSURISE EN THERAPEUTIQUE CONSIDERAZIONI SU DUE CASI DI POLI- O.R.L. (PRESSURIZED LOCABIOTAL IN BLASTOMATOSI MALIGNA A LOCALIZZAZIONE O.R.L. THERAPY.)Gazette Medicale de OROFARINGEA. (CONSIDERATIONS ON TWO FranceSuppl. 6):r747Feb 25, 1069-7 CASES OF MULTIPLE PRIMARY MALIGNANT 7175FIZW Abs.) TUMORS IN THE OROPHARYNGEAL AREA.) Annali di Laringologia, Pressurized locabiotal (an anti- 1117161417, Faringologia biotic of fungal origin with added 617-3e, 1966, Italian (Abs. anti-inflammatory properties) in the treatment of 38 patients, 20 of whom The author, having examined were neoplastic, was reported. multiple malignant tumors literature, Favorable results were obtained in particularly regarding those authors who, 81.6 percent of the cases: in nasal in the ORL field, have been interested in surgery and amygdalectomy; in irrita- superior aerodigestive neoplasms, presents tive and benign diseases when the two cases of multiple malignant primary treatment was applied at the onset tumors with a particular bilateral to reduce the toxic impregnations of localization in the oral cavity. Having tobacco, alcohol and pollen; and in considered all possible ways tumors irritative consequences of surgery spread, the author is inclined to consider and physiotherapy of neoplasms of the these neoplasms, having the same face and neck. No intolerance waa histological structure, as primary observed.The patients were reported independent. (Author Abstract) to like the pleasant odor, the ease of handling, and the decongestant and rapid antalgic action of the product. LI 11585 Javadpour, N. and Mostofi, F. K. PRIMARY EPITHELIAL TUMORS OF THE BLADDER C 11357 IN THE FIRST TWO DECADES OF LIFE.Journal Semaine des Hopitaux. of Urology 101(5):706-10, May 1969. IA BRONCHITE CHRONIQUE, MALADIE SOCIAIE. (CHRONIC BRONCHITIS, SOCIAL DISEASE.) Semaine des Hopitaux (4, Suppl 3):5-9, C 11386 En -20,rm, FrenchAbs.) Seda, H. J. and Snow, J. B., Jr. CARCINOMA OF THE TONSIL.Archives of Air pollution as a cause of chronic Otolaryngoloax 89(5):756-61, May 19;5". bronchitis and bronchial cancer has been reviewed. Several authors have demonstrated the effects of air pollution on C 11387 the blood picture and on the skeletal Cowdry, E. V. growth of populations. Components of ETIOLOGY AND PREVENTION OF CANCER IN MAN. polluted air, particularly sulfur dioxide New York, N.Y., Appleton-Century-Crofts and asAstos, were singled out for their Division of Meredith Corporation, 1968, particularly harmful effects.A study by 420 pp. Kreyeberg demonstrated the increased incidence of bronchial cancer in Norway for 1929 to 1956 in which the mortality C 11388 rate was 4 tines higher in the capital Watson, W. L. than in the ru-al areas. A similar study HISTORICAL BACKGROUND. In: Watson, showed that the mortality rate from W. L., (Editor). Lung Cancer: A Study bronchial cancer in Great Britain from of Five Thousand Memorial Hospital 19L0 to 1953 in both men and women Cases. Saint Louis, Mo., The C. V. increased with greater urbanization. Mosby Company, 1968, pp. 1-14. Researchera believe that long-term aggression by air pollutants affects the ciliated bronchial mucosa leading to C 11389 metaplasia, which is considered a Wynder, E. L, and Hoffman, D. precancerous state, and the intervention CURRENT STUDIES ON ETIOLOGY AND PREVEN- of other carcinogens in polluted air TION. In: Watson, W. L., (Editor). completes the carcinogenesis process. Lung Cancers A Study of Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby Company, 1968, pp. 15-34.

15°4 C 11390 C 11459 Watson, W. L. Etienne, J.-P., Delavlerre, Ph., OAT CELL LUNG CANCER. In! Watson, Petite, J.-P., and Sauleau, P. W. L., (Editor). Lung Cancers A Study LES LEUCOPLASIES CESOPHAOIENNES AU of Five Thousand Memorial Hospital COURS DES CIRRHOSES. (ESOPHAGEAL Cases. Saint Louis, Mo., The C. V. LEUKOPLAKIA DURING LIVER CIRRHOSIS.) Mosby Company, 1968, pp. 394-405. Semaine des Hopitaux 45(23):1589-97, W7-117 TOT97-7715UE (Ate.)

C 11391 Having noticed the frequency with Ooodner, J. T. which the esophageal mucosa in liver ADENOCARCINOMA. In: Watson, W. cirrhosis is the aite of areas of (Editor). lung Cancers A Study of leukoplakia, the authors studied the Five Thousand Memorial Hospital cases. esophagus in a group of 61 patients Saint Louis, Mo., The C. V. Mosby with cirrhosis and compared it with Company, 1968, pp. 406-9. controls. It appeared that esophageal leukoplakia, is three times more common in patients with cirrhosis than in C 11392 normal aubjeots. The authors describe Watson, W. L. the pathology of the leukoplakia lesions, TEN-YEAR SURVIVAL'A STUDY OF FIFTY- then the clinical characteristics of the SIX CASES. In Watson, W. L. (Editor). liver cirrhosis in these patients.After, Lung Cancers A Study of Five Thousand discussing the possible role of Memorial Hospital Cases. Saint Louis, leukoplakia in the production of Mo., The C. V. Monty Company, 1968, carcinoma of the esophagus, the authors PP. 514-7. review the various pathogenic factors liable to cause esophageal leukoplakia during cirrhosis and insist on the C 11393 complex uechanism of the lesions thus Schottenfeld, D. described. (Author Abstract) FACTORS BEARING ON PROGNOSIS:A REVIEW OF 3,124 CASES. In: Watson, W. L., (Editor). Lung Cancers A Study of Five C 11471 Thousand Memorial Hospital Cases. Clavenzani, E. Saint Louis, Mo., The C. V. Mosby FIBROSARCOMA PRIMITIVO POLMONARE CON Company, 1968, pp. 518-28. ESTRINSECAZIONE MEDIASTINICA ANTERIORE. (PRIMARY PULMONARY FIBRO- SARCOMA WITH ANTERIOR MEDIASTINAL C mce DEVELOPMENT.) Nuntius Radiologicus Journal of the American Dental Association. 33(12)11583-9, nram, Italian (Aos.) ORAL CANCER. Journal of the American Dental AssooiarTFIN-TU07177T,-Mr7177n. The author reports a case of pulmonary fibmsarcoma with anterior mediastinal development, rarely C 11405 described in the literature (about 30 Gerami, S. and Cole, F. H. observations). The patient was a 28- COEXISTING CARCINOMA OF THE LUNO AND year -old farm worker, a moderate PULMONARY TUBERCULOSIS. Annals of drinker and smoker (20 cigarettes per ThoracicSurgery7(4):31.77217Tpr1969. day).

C 11415 C 11482 Medical Journal of Australia. Miller, A., Mitchell, J. P., and Brown, N. CAUSAL FACTORS IN LUNG CANCER.Medical J. Journal of Australia 1(15)073-47W-- THE BRISTOL BLADDER TUMOUR REOISTRY. TG-TOTO. British Journal of Urology 41(1, Suppl.)t 1764,reb 1969. C 11456 Jenson, C. B. and Smart, C. n. C 11508 CANCER OF THE LUNG IN UTAH. Rocky Oellin, G. A. and Possick, P. A. Mountain Medical Journal 66(1)14T-50, OCCUPATIONAL CANCER OF THE SKIN. Jan T966. CutiS 5(5)1543-8s May 1969.

/33 C 11509 C 11534 (continued) De Vries, N. C. T. terms of the stage of development of the METASTASES OF SQUAMOUS CELL CARCINOMA tumor and includes: surgery, radiotherapy, OF THE SKIN AND LIP. Dermatologica cytostatic chemotherapy and a symptomatic 138(4):333-9, 1969. with anabolizing drugs, sedatives, and antibiotics in case of suppuration. C 11526 (Author Abstract) Matarazzo, R. and Corradi, O. TUMORI MALIGN' BRONCO -POLIMONARI E SESSO FEMMINILE. (MALIGNANT BRONCHOPULMONARY C 11536 TUMORS AND THE FEMALE SEX.) Archivio Riforma Medics. COMPUTER IN AZIONE PER STUDIARE LE CAUSE Italiano diatolo is e DEL CANCRO POIMONARE. (COMPUTER IN 1117 : - ,.7Ta=m713113, Ttallan (Abs. ACTION TO STUDY THE CAUSE OF FULMONARY CANCER.) Riforma Medica 83(6)in. p., The authors illustrate 21 cases of !web 8, 196% itaiiEE-768.) malignant pulmonary neoplasms in women occurring during the 1945-1959 A Univac 1107 was installed at the French national Institute for period. On the basis of the results obtained, the anatomo-clinical character- Health and Medical Research at istics and the differentiating elements Villejuif (near Paris).Linked with between male and female are discussed. the computer is the Gustave - Roussy (Author Abstract) Institute, one of the more modern cancer clinics with more than 500 beds and an annual rate of more than 30,000 C 11528 ::!nbulatory patients. The computer will A/exalder, P. handle all therapeutic data, drugs THE RELATIONSHIP BETWEEN AGEING AND prescribed, medical treatment, EKG values, and analyses of laboratory tests. In CANCER: SOMATIC MUTATIONS OR BREAKDOWN OF HOST DEFENCE MECHANISMS, Bulletin commenting on American lung cancer der Schweizerischea Akademie der statistics it was noted that almost Mizinischen Wiesenfa-MTh nr4):258- all the subjects selected from a sample 71, Jan 1969. of 1500 patients (excluding cases of asbestosis) were heavy smokers.

C 11534 Burnea, D. C 11539 CE TREBUIE SA STIR DESPRE CANCERUL Pierquin, B., Chassagne, D., Isla, F., BRONHOPULMONAR. (WHAT WE SHOULD KNOW and Vandenbrouck, C. WENDOCURIETHERAPIE DES CARCINOMAS ABOUT BRONCHOPULMONARY CANCER.) Munca Sanitara 17(1)11-11, Jan 1969, EPIDERMOIDES DU VOILE PAR L'IRIDIUM Rumanian (Abe.) 192. (ENDOCURIE THERAPY OF EPIDERMOID CARCINOMAS OF THE VELUM BY IRIDIUM Bronohopulmonary cancer is defined 192.) Journal de Radlo;ogie as the sevareet form of neoplasia, with dineceRrnrY gr ar me edine a rapid evolution towards exitue, a Fireririre bOtl-Tb73-7771,77eb 1969, difficult treatment and postoperative FRITEITcrbs.) survival of short duration. The incidence of this form of cancer is very Fifty-one cases of velar epidermoid frequent today and occupies first or carcinoma were treated at the Gustave- second place within the framework of Roussy Institute between 1959 and 1965. neoplasias, in most countries. In 1966, The results showed that the radiation in S R Romania, the mortality rate from technique utilizing iridium 192, bronchopulmonary cancer was 17.3 per preceded by or in association with 100,000 inhabitants, with a 6 to 12 teleradiotherapy, can in most instances fold higher Incidence in males.After sterilize primary tumors (more than giving certain data on the etiology, 90 percent of the cases). Survival development and symptomatology of results however, are rather poor, bronchopulmonary cancer, the author chiefly because of adenopathies which emphasized the importance of the are frequent, bilateral and difficult investigations carried out for an early to cure, as well as eecondary tumoral diagnosis: the roentgenogram, bronchos- localizations. In all, close to 20 copy, bronchography and anatomo-pathologic percent of the cases died of eecondary examination. For appraising the extent of localizations, only 10 percent of local the tumor, he recommends the use of eso- recurrences, less than 10 percent of gastric barium transit, pulmonary metastases, less than 10 percent of scintigraphy, azygography.The treatment intercurrent diseeees, and more than of bronchopulmonary cancer is applied in 10 percent were loet from view or C 11539 (continued) C 11573 died of undetermined causes. At 3 Heyden, S. years, less than 30 percent survive, EP/DEMIOLOOIE DES KARZINOMS DER BRUST, Who, according to mortality tables for DES MAGENS, DER SPEISEROHRE, DER LUNGE, velar cancer, barely exceed 20 percent DER HARNBLASE UND DES M. HODGKIN. at S years. (EPIDEMIOLOGY OF CARCINOMA OF THE BREAST, STOMACH, ESOPHAGUS, LUNG, BLADDER, AND HODGKIN'S DISEASE.) C 11543 Deuteches Medizinischea Journal 20(1): Capronnier, C., Rulliere, R., and 3717-7iirl, 1969, German) Bariety, M. METHODES ET RESULTATS DV DEPISTAGE Three - fourths of all clinical cancers, DV CARCINOME BRONCHIQUE. according to the World Health Organization, (METHODS AND RESULTS OF THE DETECTION were directly or indirectly, the result OF BRONCHIAL CARCINOMA.) Bulletins of external factors whose incidence in et Memoiree de la Societe ggrnlnItrifee-TATITIII large part can be reduced. Several select ): forms of cancer in different countries and FM, Dec 13,75rN7French Abs.) populations have been reviewed, showing that nutritional or other factors may have The authors think that the a bearing on the incidence of the cancers. detection of bronchial carcinomas The association between cigarette smoking should be improved, on the individual and lung cancer was also discueaed.Heavy plane at leact but it would also be smokers also run a three-fold risk of desirable on the collective level. acquiring key and bladder cancer as Currently several detection methods compared with nonsmokers.Using the are in use and these should be examples of portio-and corpus uteri, associated rather than exclusive. stomach and esophageal cancers, the Two principal techniques can be carcinogenesis of each segment being tilized, (1) radiological detection different and specific, the author and (2) cytological detection by stressed the importance of reporting the examination of the sputum. Radiography precise description of the localizations of the thorax is the simplest method. of the individual cancers.A table was Cytology of the sputum is a finer method presented indicating that early diagnosis but its execution and the interpretation of different cancers could result in an of the results are difficult.Biological average cure-rate of 40 percent. anomalies of the blood and urine have been observed, and if the specificity of such analyses could be improved, the detection C 11578 of the cancer would be facilitated. Bulian, T. RILIKVI CLINICO-STATISTICI SUI CANCRI POLMONARI A NODO UNICO. (CLINICAL AND C 11544 STATISTICAL FINDINGS IN SINGLE-NODE Ashley, D. J. B. LUNG CANCERS.) Minerva Medics 59(102): SEX DIFFERENCES IN THE INCIDENCE 5710-29, Dec 22,WILITIR7 (Abs.) OF TUMOURS AT VARIOUS SITES. British Journal of Cancer 23(1): Personal findings in a series of single- 26-30, xinFimmr. node lung cancer cases showed that such tumors pass through a long period of clinical silence; if operated in time, C 11564 i.e. before clinical eigns are observed, British Medical Journal. they are the most likely of all lung EPIDEMIOLOGY AND PATHOLOGY OF canters to be followed by positive cure PREMALIONANT LESIONS. Britiah Medical and long-term postoperative survival. Journal 2(5658):570, They are easily visualized as roundish shadows on the X-ra;' field long Wore they become clinically evident, and C 11566 regular mass screening is clearly t,o, Weir, J. M., Dunn, J. E., Jr., and be recommended, ',specially in the case Buell, P. E. of persons who, by reason sex, age SMOKING AND ORAL CANCER: EPIDEMIOLOGICAL and habits ,.re more prone to such forms. DATA, EDUCATIONAL RESPONSES. American Once they have been discovered, one must Journal of Public Health and tE17------not wait in the hope of obtaining a fratirTnelTentrnt611959'W,-717n1969. more accurate diagnois, but be prepared to reach such a diagnosis via surgical exploration. (Author ;,ostvact)

133 13? C 11582 C 11594 continued) Lynch, H. T. in the report here wee on the more usual HEREDITY AND CANCER.Nebraska State locations of the tumors such as of the Medical Journal 54(5):268-9, M47176-9. skin, bladder, respiratory tract, and the hemopoietic system. Some general sugges- ti-ns for the prevention of +ccupational C caLers were offered. '.imington, J. SMOUING, SPUTUM, AND LUNG CANCER. Maryland StateMedical Journal 18(1): C 11598 85"17-76177 Linn, B. S. and Snyder, G. B. SIGNIFICANCE OF THE PRIMARY IN METASTATIC CANCER OF THE NECK. Southern Medical C 11585 Journal 62(5):615-9, any ing% Holaday, D. A. HISTORY OF THE;;;CslIcIR8E12147flalps? RADal. Health C 11600 key 1969. Haenszel, W. REPGET OF THE WORKING OROUF ON STUDIES OF CANCER AND RELATED DISEASES IN C 11586 MIGRANT POPULATIONS. International Gilbertsen, V. A. and Lillehei, J. Journal of Cancer 4 {3):364 -71, Flay THE CHEST X-RAY IN THE DIAGNOSIS OP rs;rgrs. LUNG CANCER. British Journal of Clinical Practice 23(4)1149-52, Apr 1969. C 11603 Dawes, J. D. K., Harkness, D. G., C 11592 Marshall, H. F., and Van Miert, P. J. TEppeiner, J. and Wolff, K. MALIGNANT DISEASE OF THE NASOPHARYNX. FAPILLOMATOSIS MUCOSAE CARCINOIDES Jo-rnal of trivrawLer and Otolum ("CRAL FLORID V.PILLOMATOSIS"). IrStrri.71r73, r Hautarzt 20(3)0102-8, Mar 1969, trairgirrAhs.) C 11608 The nature and nomenclature of a Wolinsky, 3., Lin, A., and Williams, verrucose- tumorous hyperplasia of M. H., Jr. the mucosE of the mouth and lip were LUNG PERFUSION IN BRONCHIOLO-ALVEOLAR discussed. Three cases were presented CARCINOMA. (A Case Report) American by the author along with a literatur3 Review of gerspigt:ry Diseasu review of similar cases.The clinical 1§(1,Part170585 -9, AFF-1767. similarity to a carcinoma was evident but histological investigations confirmed C 13526 the ncnmalignity of the processes. A Bulletin cot.he Philadelphia County viral cause was rejected.Chronic Dental Society. traomatizAtion by smoking or wearing AD.! CALLS SMOKING A CLEAR AND SERIOUS of prosthesis was not conclusive PUBLIC HEALTH ME5iAC2). Bulletin of the :barely 20 cases were published and Philadelphia Count DenEai Societe smoking habits and prosthesis wtre not nrgTs26", may- un, mentioned). The necessity for frequent control was indicated, in view of the nosological arrangement of such conditions C 11632 as precancerous and the possibility of Donaldson, A. W. malignant 4egenenation. Tit, EPIDEMIOLOGY OF LUNG CANCER AMONG URANIUM MINERS. Health Physics 16(5): 563-9, May, 1969. C 11594 Do Amaral Rocha, A. and R:eno, 2. CANCER OCUPACIONAL. (OCCUPATIONAL CANCER.) C 11633 Hopital 74r:1985-96, Dec 1968, Eolea, R. and Komorn, R. or ugoeso Abs.) CARCINOMA OF THE LARYNGEAL GLOTTIS: A FINE-YEAR REVIEW AT A UNIVERSITY HOSPITAL. Experimental data End epidemiolcgical Laryngoscope 79(5):909-20, May 1969. observations were summarized. A number of known chemical carcinogens and cocarcinogens in th) form of dusts, vapors C 11635 anj gases were listed.Also mentioned was Peacock, P. R., Biancifiori, C., and the role of ionizing radiation in the Bucciarelli, E. development of the cancers. The emphasis RETROSPECTIVE SEARCH FOR ASBESTOS BODIES

134 138 C 11635 (continued) C 11676 (continued) IN NECROPSIES AND BIOPSIES ON CASES OF PRIMARY MALIGNANT DISEASE OF THE LUNG. The logic in the evaluation of Euro can Journal of Cancer 5(2):147-53: statistical dais concerning the relationship ',etween smoking and lung cancer was discussed. It was considered remarkable that such an intensive and C 11642 cohcentrated effort on one subject Medical News, resulted in no clear decision. This CANCER LINK QUESTIONED IN SMOKING. was primarily attributed to the fact Medical News (344):16, May 9, 1969. that two powerful organizations approached the subject with entirely different motives, one group obtaining C 11653 grants for "basic" or "qualitative" Leadbetter, W. F. research which deny that medical SURGERY FOR MALIGNANT DISEASE OF THE statistics may be an instrument of BLADDER. In: Glenn, J. P. and Boyce, causal research.The difference in the W. H., (Editora).Urologic Surgery. incidence of lung cancer in men and New York, Evanston, and London, Harper women was attributed to the more recent & Row, Publishers, 1968, pp. 273-304. aquisltion of the smoking habit by women. Also included was mention of data that the decisive factors 1G the C 11656 mortality of married vs. nonmarri9d, Ashley, D. J. B. widowed or divorced women were changes BLOOD GROUPS AND LUNG CANCER. Journal in ambient conditions. of Medical Genetics 6(2):183-6,77,FTIS9.

C11693 C 11661 Baron, F., Joinville, R., Kernels, J. P., Coy, P. and Orzyoowskl, S. De Lajartre, Lenne, and Bruneau, Y. SCREENING FOR LONG CANCER IN BRITISH TUMEURS BLANCHES DU LARYNX ET CANCER. COLUMBIA. British Columbia Medical ("WHITE" TUMORS OF THE LARYNX AND Journal 11(7):207-87-717117617 CANCER.) Journal Francais d'Oto-Rhtno- Laryngolode ecchlrurgie 161-5)T18r-S, 1967,77-er1T (Abs.) C 11665 Seltzer, A. P. "White" tumors (leukoplakias, PALPATION OF THE NASOPHAllYNX. corneous keratoses, parakeratoses, National Medical Association 61(4): and papillomatoses) usually involve the 350-1, JuI 1969. male sex. The average age is about 54 years and the tumora appear to develop under the influence of a common C 11668 aggressor: all are heavy amokers, and Weiss, W., Cooper, D. A., and Boucot, if not smokers, remain permanently K. R. exposed to a tobacco smoke atmosphere as OPERATIVE. MORTALITY AND 5-YEAR in offices or cafes. Six case histories SURVIVAL RATES IN MEN WITH BRONCHO- were presented here. Macroscopically, GENIC CARCINOMA.Annals of Internal all exhibited the same lesions but Medicine 71(1)15945, the histological examination revealed fundamental differences permitting classification into three iistinct C 11669 groups. Four oP the patients were Falor, W. H., Gordon, M., a..,d bearers of leukoplak418, discretely Kaczalft, 0. A. villous, localized in one vocal cord, CHROMOSOMES ,1N BRONCHOSCOPIC BIOPSIES. most often median, with extension toward Cancer 24(171198-2C9, Jul 1969. the commissure but the larynx was perfectly mobile.

C 11676 Feiner, S. C 11694 RICEHCHE QUANTITATIVE IN BIOLOOIA E Pedersen, E., Magnus, K., Mork, T., MEDICINA nMANA. Rapport! Socloblologici: Hougen, A., Bjelke, E., Hskama, M., and Stato Mritale, Tabacco. (QUANTITATIVE Saxen, E. RESEARCA IN HUMAN BIOLOGY AND HUNAN LUNG CANCER IN FINLAND AND NORWAY. MEDICINE. Sociobiological relation- An Epidemiological Study. Acta shipst Marital State, Tobacco.) Pathologica et Microbiologhica Minerva Medica 59(79):4124-5, Oct 3, ScandinavIZerSuppl 199J, 1969, 63 pp. rwrarrtratr(Abso

135 139 C 11724 C 11731 Roche Medical Image & Commentary. Fort, L. and Taper, H. S. BETEL QUID CANCER.Roche Medical L'ACTIVITE HISTOCHIMIQUE DES NUCLEASES Image & Commentary 1107:1r:57--- ALCALINES ET ACIDES, COMPAREE A L'INCIDENCE Jun 1959. DES CARCINOMES DANS LE SYSTEMS DIGESTIF DU RAT. (THE HISTOCHEMICAL ACTIVI1V OF ALKALINE AND ACID NUCLEASES, IN COMPARISON C 11725 WITH THE INCIDENCE OF CARCINOMAS OF THE Bauer, K. H. DIGESTIVE SYSTEM OF RATS.) Patholo is EPIDEMIOLOGJt OEOGRAFICA E DEMOGRAFICA Europaea 4(1):42-57, 1969, Frenc s.) pRE- E CANCEROSA. 11 Pericolo Canceroso Dell'uomo D'oggi: Et Possibile una The alkaline and acid nue): saes were Profilassi Anticancerosa? (GEOGRAPHIC AND studied histochemically in different PRECANCEROUS AND CANCEROUS DEMOGRAPHIC segments of the digestive system in EPIDEMIOLOGY. The Present cancer Risks normal albino rate. A correlation between in Humans: Is an Anticancer Prophylaxis low activity of nucleases and increased Possible?) Minerva Medica 59(79)14111-4, incidence of carcinomas in some parts of Oct 3, 1968,71granW) the digestive system was demonstrated. The data from the literature indicate The increase in cancer mortality an, that carcinomas, both spontaneous and in- the changing ratios in men and women in duced by nitrosamines, were found nearly recent years and decades were discussed. exclusively in the oesophagus, forestomach, The parailel between the rise in cancer stomach and large intestine, precisely in mortality and the lengthening of the human these segments where a low activity of life span was also noted. Bronchial nucleases was demonstrated in the carcinoma was selected as an extrema ex- present study. On the other hand carcino- ample in which the t:cidence in a single mas are rarely observed in duodenum and organ had increased almost 30 times from small intestine, where the activity of one genaraticn to the next. Elimination nucleases is increased. This observation or reduction of hazardouc external factors gives an additional support to the hypoth- could reduce the incidence cf bronchial esis previously elaborated in a similar cancers as well as cancers of the skin, study on the central nervous system of osseous system, thyroid, genitals, and normal rat (TAPER and BRUCHER, 1969). intestinal tracts and leukosis and According to this hypothesis the low leukemia. activity of nucleases in normal tissues is a predisposing factfsr for malignant transformation.Therefore it could be C 11727 supposed that the nucleases constitute Hoppe, R. some kind of double barrier mechanism BRONCHOLOGISCHE UNTERSUCHUNGSSTELLEN ZUR protecting the genetical stability of FRUHERFASSUNG DES LUNGENKRESSES IN the cell against foreign nucleic acid NORDRHEIN-WESTFALEN. (BRONCHOLOOICAL incorporation or production) alkaline INVESTIGATION SITES FOR EARLY RECOGNITION nucleases being an extracellulPr and acid OF LUNG CANCER IN NORTH RHINE-WESTPHALIA) nucleases an intracellular barrier. Gesellschaft zur nBakalpfung der (Author Abstract) riZbskrenkheirgri 17(51eF5Fir1=Winfalen e.v. ATIEFTrUMPTOTEit 5(2):226-42, Oct 1988, German tAts.) C 11740 Chiurco, G. A. Results of the investigation of 1,577 PRE- E NEOPLASIE VERE E SOSPETTE DA cacao utilizing different diagnostic LAVORO E DA AMBIENTI. Lavoro Umano techniques were reviewed. Tables give e Malattie: Pre- e Tumori krofessionali. breakdowns by age an4 sex, symptoms, (FRENEOPLASIA AND REAL AND SUSPECTED accompanying illnesses, loPation of NEOPLASIA AS A RESULT OF OCCUPATION AND tumors, and smoking histories. Males ENVIRONMENT. Human Work and Diseases: represented 88 percent of all cases. Pre- and Occupational Tumors.) Minerva Forty percent of all individuals were Medica 59(79):4171-98, Oct 3, 19M-- liated se heavy emokers, 33 percent as rum (Abs.) moderate smokers and 17 percent nonsmok- era. Malignant tumors were found in Results of 17 years of research of 40 percent of the heavy amokerc, in 42 the Centro Precanceroao which was percent of the moderate szezers and in 23 created in 1951-52. The research was percent of the nonsmokers. The per- bated on many thousands of cases reported centage Of nonsmokers with bronchial car- in Europe and elsewhere and included 1167 cinoma is higher than generally given by cases of lung cancer (1035 men and 132 other authors. women) of whom 19.66 percent were smokera, 7.10 percent nonsmokers and 13,27 percent with no data on amoking habit. The

136 /40 C 11740 (continued) C 11745 (continued) percentage of known smokers was much characterized by a rapidly developing higher in men than in women (88.90 and symptomatology, is presented, and the 6.47 percent, respectively). most important aspects of this relatively rare neoplasia are discussed. Most frequently, the site of malignant C 11744 leiomyoma (or leiomyosarooma) is in the Berti, P. inferior lobe and the middle lobe, but CELLULE ALVEOIARI NELLO SPUTO IN this disease can arise in the remaining PORTATORI DI CIACINOMI POLMONARI. pulmonary lobe as well. Clinical symptoms (ALVEOLAR CELLS IN Tr" SPUTUM OF of the disease include coughing and S L MON0A(R9) OMS.) thoracic pain.Dyspnea, hemoptysis, and MBEAReEaMOFedPUa :3RC-9N, fever are frequent manifestations and 31, 195971"aTian (Abs.) in some cases compro.-ased nutrition and conspicuous anemia may occur. Radiology A sunnary is presented of a study by doeo lot usually enable diagnosis of S. and M. Masin, published in 1968, malignant leiomyoma. Based on analysis showing that characteristically a greater of cases in the literature, a notable number of alveolar cells ar' found in the difference in evolution has been deduced. sputum of patients with pulmonary car- A relatively favorable prognosis has been cinoma than in those affected by other alleged by numerous authors, particularly types of respiratory illness. The study in view of the long clinical latency and population comprised patients divided in- good surgical possibilities. Pneumonec- to three groupas (1) 164 ninsmokers with tomy, first successfully performed in slight or .1c, symptoms of respiratory 1976, has been efficacious for many pat- illness; (2) 869 smokers with high risk ients. Ths anatomical-histological pec- who smoked one or more packs of cigarettes uliarity of the tumor leads to the daily and were admitted to the clinic diagnosis of malignant leiomyoma.From because of chronic respiratory illness the clinical point of view, the histo- (bAonchitis, emphysema, etc.); and (3) 77 logical investigation is of primary bearers of pulmonary carcinoma.Group importance since it yields useful bioptic 1 patients had a percentage of macrophages information through bronchoscopy. in the sputum of about 58.7, the second group had 33.51 percent, and the third 35.52 percent. Lipophagea were found (' 11747 in he sputum cf 28.26 percent of Group Fossett, C. 1 patients and in 50 percent of both INCIDENZA DEL CARCINOMABRONCOPOLMONARE Group 2 atei 3 patients. Other findings NELIA DONNA.Rilievi Clinico-Statistici reported were that five times more gross Effettuati in Arabo-Libici Negli Ultimi dimensions of particles included in the Dieci Anni. (INCIDENCg OF BRONCHO- lipophages were discovered in patients PULMONARY CARCINOMA IN WOMEN. Clinico- with tumors than in the nonsmoxers or the Statistical Surveys of Arab Libyans high risk smokers; gross inclusions were in the Last Ten Years.)Rassegna not found in the university students or Clinico-Scientifica dellIxstitao the industrial workers, With regard to ITMETrnico Itaiiano 2) 49 -53, hyperplastic bronchial cells, a signifi- rirringrairrirsirsAbs. cantly higher percentage was found in the bearers of carcinoma; the nonsmoking Following a brief review of literature patients e:id smokers with higher percent regarding the greater prevalence of ages of these cells than the nonsmoking bronchopulmonary carcinoma among men than university students and industrial workers. women and the recent rise among women, a Differences observed among 011 subjects study conducted on the incidence of with regard to the five classifications bronchopulmonary carcinoma in women in of cells found in the sputum Are summari . Libya during the last 10 years is zed. discussed. As early as 1931, the possible relationship between lung cancer and tobacco consumption was postulated. C 11745 Since then, among other findings; it Bisetti, A. and Lodi, R. has been reported that in the past fewer LEIOMIOMA BRONCHIALE MALIGN() A RAPIDA women than men developed lung cancer EVOLUZIONE. (r.PIDLY DEVELOPING because of their lower consumption MALIGNANT BRONCHIAL LEIOMIOMA.) Riviata of tobacco; that women are more sensitive della Tubercolosi e dells Mslattir----- to the toxic effects of. tobacco; and that 3iTTYAI)parsto ReipTrITITroI6I2)2151-65, deleterious effects have been ev,lented FMApr19613, Italian (Abs.) in the offspring of women who are heavy smokers. In the study reported, 264 cases The case history of a 38-year-old man of bronchopulmonary carcinoma among Arab- with malignant bronchial leiomyoma, Libyan people in three provinces of Libya

117 C 11747 (continued) C 11750 (continued) during 1957-66 were investigated.The subjects ranged from 30 to 64 years of The organization and functions on the age, with the higheat incidence (25.9 per- provincial and national levels were cent) of bronchopulmonary carcinoma oc- outlined. The functions would include curring among those 50-54 years of age. control of the more important oncogenic A total of 27 (10.22 percent) of the sub- factors of external origin such as jects were women.Eight of these 27 ionizing radiation, colorant and food women had a family history of cancer; 16 preservative additives, smoking, and lived in cities and 11 in desert areas. atmospheric pollution. With regard to smoking, a most prevalent habit among Arabs (even women abuse tobacco and not solely in cigarette form), it C 11751 was found that all 27 women smoked, 9 of Sirtori, C. them being light cigarette smokers, 10 8101007A DEL CANCRO POLMJNARE. average to heavy, smokers, and 7 very (BIOLOGY OP PULMONARY CANCER.) heavy smokers. The clinical symptoms Riforma Medicos 82(34)1929-52, Aug included coughing and expectoration, Mrrel787TriTian(Abs.) fever, thoracic pain, and dyspnea. In 11 of 27 cases, the disease was very advanced, Various agents capabl, of inducing and inoperable, death was imminent; in lung cancer were revicwed, including the remaining 16, surgical treatment was benzopyrene in cigarette smoke and in possible, but 7 of these refused surgery. air pollution, nitrosamines, DMBA, This study confirms the higher incidence urethane, tare, chromium, asbeatos, of lung cancer among men than women, as nickel, viruses, and X-radiation.The well as the important relationahip of genetic make-up of the individual and heavy tobacco smoking to lung cancer. the psyche were also believed to play a role in ca-:inogenesis.Vitamin A can reduce the carcinogenic activity of C 11748 chemical carcinogens and benzopyrene Chiurco, 0. A. hydroAylases can inactivate DMBA and EPIDEMIOLOG1A OEOORAFICA E DEMOGRAFICA acetylaminofluorene as well as benzo- PRE- E CANCEROSA. (GEOGRAPHIC AND pjrene. The different periods of time FRECANCEROUS AND CANCEROUS DEMOGRAPHIC required for the emergence of carcinoma EPIDEMIOLOGY.) Minerva 'lexica 59(79)1 in situ in different tissues of the body 4114-20, Oct 3,r7T,TtaTraT-1(Abs.) gerrillted. Immunological aspects of pulmonary tumors were briefly discussed. Several epidemiological studies, The author also advanced his own theory internationai congresses on cancers, and of preventive treatment by administration the establishment of tumor registers in of useful drugs to everybody in the various countries were noted.No specific generally affected age group, as for data were included although a French study example, to everyone above 50 years of confirmed the relationship of alcoholic aje to be given every 3 to 4 pare.His abuse and certain cancers. The report own experiments with the regression of closed with some comment on the purposes carcinoma in situ were cited. and output of the three international seminars on cancer prophylaxis in Rome in 1965-68. Meinemaia reports on antismoking C 11759 campaigns in Holland in connection with Jelinek, R. lung cancer and cardiovascular diseases MULTIPLIC1TA KARCINOMU HRTANU A were mentioned. The insufficiency or PRUDUSEN. (MULTIPLICITY OF absence of statistical data concerning CARCINOMA OF THE LARYNX AND precancerous states or occupational tumors BRONCHI.)Ceskoslovensks was criticized. Doctors were urged to Otolaryngoloeie 18(1T!40-1, study the psychosomatic or psychoneuro- Feb 196w, CzeFg (Abe.) pithic state of subjects in the etiology of tumors. The mithor describes three patients tho developed a secondary carcinoma of the larynx after four, C 11750 two-and -a-half and five years fol- Nuzzolillo, L. lowing total laryngectomy. The LiORGANIZZAZIONE DELIA LOTTA CONTRO I average age of the patients was 58 TUMORI IN ITALIA. (TYE ORGANIZATION OF years. All three patients were THE FIGHT AGAINST TUMORS IN ITALY.) heavy smokers. (Author Abstract) Minerva Medic& 59(79);4121-2, Ott 3, rwrmalirrubso

138 148 C 11762 C 11769 Balenko, N. V. Wolf, H., Wavnknecht, L. V., and Madsen, MOM:WV-Ent-EWE 000640410Cro 3WIEN4C-ITAn6HIT0 P. O. MAIEMOX. DIE ATIOLOGIE UND PATIUMENESE DES MORFOGENETICHESKIYE OSOBONNOSTI BLASENCARCINOMS. (THE ETIOLOGY AND EKSPERIMENTALTC00 RtKA LEOKIKH. PATHOGENESIS OF BLADDER CARCINOMA) (MOROPHOLOGICAL PECULIARITIES OF Urolo e 8(2)81-96, Mar-Apr L969, EXPERIMENTAL LUNG CANCER.) er n (Abs.) Vrachebnoe Delo (4)117-20, Apr 1969, ausaian tAbW77 An outline of recent investigations and theories concerning the etiology and A comparative evaluation of pathogenesis of bladder cancer ie present- human and experimental lung cancer ed. The known bladder carcinogens in man is presented. Bronchogenous lung are listed. These chemicals frequently cancer induced experimentally in appear as by-products in various indust- rats by intratracheal administration ries. The experimental induction of of 3,4-benzopyrene showed similari- bladder cancer in animals ie outlined in ties with human lung cancer histolog- detail. The metabolic pathways of the ical types.The number of induced aromatic amines, in particular tryptophan, tumors and their histological struc- including excretion studies in humans and ture depended on the dosage of experimental studies in animals, which carcinogenic substance. The corre- are important in the etiology of certain lation of various histological types bladder cancers are outlined and the of human lung cancer in the autopsy different carcinogeneals theories are room and surgical material, the pre- presented.Our knowledge concerning the sence of mixed carcinomas evidence exact mechanism of carcinegenesis le multipotential properties of cancer reviewed.The relationship between tobac- epithelium to transform from one type co smoking and bladder cancer, and bil- into another.This ie also corrob- harziosis and bladder cancer 18 consider- orated by the nolymorphism of neeplastic ed. The endemic nature of bladder cancer processes observed in the experiment. in cattle in certain parts of the world (Author Abstract) is discussed. A complete literature reference is given. (Author Abstract)

C 11763 Veeze, P. C 11771 VERTRAGING BIJ HET DIAGNOSTISEREN 011er Corominas, F., Raventos Moragas, A., VAN LONGCARCINOOM. (DELAY OF THE and Pinol Aguade, J. DIAGNOSIS IN LUNG CARCINOMA.) CANCER DE LENGUA. ((LINGUAL CANCER.) Nederlands Tijdschrift voor Medicine Clinica 52(3)1198 -208, Mar 1969, (1Wial7sisrlae 113117):74-3777Apr 26, STATIIEVWF7T-- 1969,1Jut76 (Abs.) Between 1948 and 1967 we received in In 81 out of 580 patients (i.e. our Department of Dermatology 132 pat!ents 1 in 7) with carcinoma of the lung, with lingual carcinoma, that ie 0.2 per- there Mme a considerable delay before cent of all the patients seen in Dermato- the k:orrect diagnosis was made after logic Clinic and 5.2 percent of all the roentgen indications of the disease cases of carcinoma of skin and muccses. had already been detected. The Out of these 132 patients only 46 have median duration of the delay in 71 been controlled for more than five years out of these 81 cases was more than and 22 have not yet reached this period 12 months. The diagnosis was delayed of control. The outset of the carcinoma comparatively more often in women and occurred between 50 and 70 years of age, in cases detected during mass surveys. nearly always in males. The sites of The causes of the delay were analysed prefarent localization are the borders in 62 cases and some frequently occur- of the tongue.The sepsis and defective ring medical and clerical errors could hygiene of the oral cavity are factors be identified. In 45 patients, an of importance in the development of incorrect diagnosis had been made lingual carcinoma. Further 20.45 percent first. The author discusses the of the patients were luetic and 4 diabet- problem of adequately examining pa- ic; in those cases, especially in the tients without causing them undue diabetic, the prognosis is much more un- difficulties, and some specific recom- favorable. The patients had been in the mendations are made. (Author Ab- majority great smokers. In all the stract.) Cases the clinical examination looking for adenopathies has not been sufficient and we had many surprises.Radiumuncture has been our elective method of treatment. (Author Abstract)

139 '43 C 11775 C 11817 MacCy.b, W. S. Barton, R. T. DIAGNOSIS AND TREATMENT OF ORAL CANCER. MONOBLOC RESECTION FOR CARCINOMA OF Tr: Oral Cancer. Interprofessional THE FLOOR OF THE MOUTH. Laryngoscope Symposium, U.S. Department of Health, 79(7):1307-14, Jul 1969. Education, and Welfare, Public Health Service, Public Health Service Publication No. 1806, 1969, pp. 17-26. C 11818 Harington, J. S. THE SECOND INTERNATIONAL CONFERENCE ON C 11776 THE BIOLOGICAL EFFECTS OF ASBESTOS. Bradshaw, E. and Schonland, h. South African Cancer Bulletin 13(2): OESOPHAGEAL AND LUNG CANCERS IN NATAL Ulirgrr: AFRICAN MALES IN RELATION TO CERTAIN SOCIOEC)NOMIC FACTORS.British Journal of Cancer 23(2 ):275-8; C 11824 Jun 19619. Shaheen, O. H. MALIGNANT DISEASE OF THE MOUTH. Practitioner 203(1213):23-9, Jul 1969. C 11777 Auerbach, O. CANCEROUS AND PRECANCEROUS LUNG CHANGES: C 11833 A SLIDE REVIEW. CA 19(3)1138-45, May-Jun Likhachev, A. Ya. 1969. KCMEMPOBAHHOE AEACTOLIE KAHOEPOIEH-40

C 11788 KOMBINIROVANNOE DEYSTVIYE KANTSEROGENNYKR Staszewski, J. VESHCHESTV. (COMDINED ACTIVITY OF CAR- SMOKING AND CANCER OF THE ALIMENTARY CINOGENIC SUBSTANCES.) Voprosy TRACT IN p0ND. British Journal of Onkologi1 14(10)0.14-24, 1968, 'Russian Cancer 23(2):247-537-5.7r1969. lAbs.r---

A review is made of experimental C 11789 findings reported in the literature Du Plessis, L. S., Nunn, J. R., on the mechanism of action of various and Roach, W. A. carcinogens, particularly when used in CARCINOGEN IN A TRANSKEIAN BANTU combination.Among the carcinogens FOOD ADDITIVE.Nature 222(5199): considered are aromatic hydrocarbons, 1198-9, Jun 21, rusir:- nitroaaminea, and aromatic amines.

C 11790 C 11838 Asian Medical Journal Zielhuis, R. L., Roegholt, M. N., TPnEAT OF LUNG CANCER. Asian Medical Hage, F. C., and Drogendijk, A. C. Journel 12(5):356-7, May11167. DE FACTOR LUCHTVERONTRETNIGINO IN HET ROKEN-LONOKANKERVHAAGSTUK. (THE AIR POLLUTION FACTOR IN THE C 11791 SMOKING-LUNG CANCER KOBLEM.) Montana, G. S., Hellman, S., Von Essen, Nederlands Ti schrift voor C. F., and Kligerman, M. M. OTTIETIMITe 71n2-47Jun 18, CARCINOMA OF THE TONGUE AND FLOOR OF 1966, Dutch (Abs. THE MOUTH.Results of Radical Radio- therapy.Cancer 23(6)0284-9, Jun Three correspondents, R. L. 1969. Zielhuie, M. N. Roegholt, and F. C. Rage, in three separate letters to the editor, have commented on an C 11807 article by A. C. Drogendijk which Eye, Ear, Nome h Throat Monthly appeared in Nederland. Tijdschrift CIGARETTE SMOKING IN RELATION TO LUNG voor Geneeskunde 110:873, 1966 con- CANCER. Eye. Ear,Nesek Throat cerning the relative roles of air Mont $112 4M) 1371-37 -11,117 pollution, pipe-, cigar-, and cigarette smoking and inhalation. Drogendijk replied to each separately. C 11813 Dickinvn, J. I. DEFEATISM IN LUNG CANCER. Journal of C 11854 the Medical Association of Borg rK Racugno, V. and Cossu, F. 511r0737-4,Jun 1969 . INFLUENZA DEL FUMO DI TABACCO NELLA

Sco / 44 C 11854 (continued) C 12860 (continued) GENESI DELLS LEUCOPLACHIE E DEI MOSELWINZERN. (DELAYED ARSENIC CARCINOMI DEL CAVO ORALE, CON DAMAGE IN AUTOPSIED MOSELLE VINEYARD PARTICOLARE RIGUARDO AI FUMATORI DI WORKERS.) Medizinische Welt 20(191 SIGARO A 'FOGU A' INTRU". (INFLUENCE 557-67, Mar M-1-9-07-Cerman (Abs. OF TOBACCO SMOKE IN THE GENESIS OF LEUXOPLAKIAS AND CARCINOMAS OF THE Use of arsenic-containing insecti- ORAL CAVITY WITH PARTICULAR ATTENTION cide sprays in vineytrda was forbidden TO REVERSE SMOKING OF CIGARS.) in 1942, but late-appearing arsenic- Minerva Medics 60(30:1514-5, Apr 18, caused disorders of the akin and in- 1969, ItriTEK-(Abs.) ternal organs still come to light. Of 100 Moselle vineyard workers who A high incidence of leukoplakiae were autopsied in 1960-66, araenic- and neoplastic lesions have been caused skin damage was found in 83 observed in reverse smokers. The cases and malignancies in 85; the leukoplakiss were generally localized malignancies were the cause of death in the hard palate as compared with in 75 of the cases.Numerically, 65 leukoplakias of the oral mucosa in malignancies were of the respiratory normal smokers.A study of 300 reverse organs, 23 of the skin and 3 of the smokers revealed an incidence of such larynx. The high incidence of liver leuk:plakias in 90 percent of the damage was also worth noting. Syntropy smokers.Malpighian caroinomas of the of arsenic-caused skin damage and palate were rather frequent and were malignant tumors of the internal organs believed due to degeneration of the could not be proved atatietically, leukoplskiss The tumors' gradually but second cancers were observed in developed infiltrative characteristics 29 percent of the arsenic-charged and spread to the jawe.Metastases of workers and only 1 percent in ordinary the hard palate were no more frequent autopsy. With a latent period of Lhan those of tho soft palate.Radio- 3S-50 years, as calculated from the logical techniquot are employed in the literature, one could expect additional therapy of the leukoplakias and carci- malignancies to appear as late as the nomas of reverse smokers. nineties. The influence of :looking could not be ascertained but smoking was viewed as merely an additional C 11858 factor in the development of bronchial Acone, L, and Cittadini, A, carcinoma. NOSTRE ESPERIENZE IN TEMA DI DEPISTAGE PRECOCE E DI DIAONOSI UTILE DELLE NEOPLASIE POLMONARI. (OUR EXPERIENCES C 11865 WITH EARLY DETECTION AND USEFUL DIAG- Pauli, G., Witz, J.-P., Morand, O., and NOSIS OF PULMONARY NEOPLASMS.)Reese a Oudet, P. Internazionale di Clinica e Tera a CONTRIBUTION A L'ETUDE DU CANCER 4-9(8):472-82, A157, 3171779, n BRONCHO-PULMONAIRE PRIMITIP CHEZ LA FEMME. (CONTRIBUTION TO THE STUDY OF PRIMARY BRONCFOPULMONARY CANCER IN Some general premises on the WOMEN.) Journal Francais de Medctine present lung cancer mortality and the et Ohiruri1Z-TH3rgertraM7):741-56, medical and social problems connected Re-Dec 1968, rencn (7C6s.) with the efficacious prevention of the disease were discussed. The Fifty cases of malignant tumors of concepts of 'early detection" and the bronchi in women were observed between "useful diagnosis were explained. 1952 and 1965. Histological examinations The most suitable techniques and were positive in all cases. Twelve of the measures to reveal neoplasms of the cases were diagnosed as primary and 38 as respiratory apparatus in a population, apparently primary.Twenty-four were of especially in the light of the authors, the cylindrical type (11 of which were own experiences, were then illustrated. broncho-alveolar), 10 anaplastic, 8 Three cases of pulmonary cancer were epidermoid and 8 of unknown origin. presented. The cancers were detected From the radiological point of view, in the preclinical phase and the primary and apparently primary tumors diagnoses confirmed in accordance with were proximal or central in 52 percent the procedures outlined in the report. of the cases, peripheral in 32 percent, and both in 16 percent. Bronchoscopy was outetandtng in diagnosis (73 percent C 11860 of the eases) of the different diag- Denk, R., Holzmann, H., !Arlo. H.-J., nostic) me/tut:me emplOyed. Complete and Greve, D. surgical removal was performed in 19 USER ARSENpATSOHADEN BRI OBDUZIERTEN cases, 3 of which were alive 5 years

141 /45 C 11865 (continued) C 11874 (continued) after surgery. Smoking histories lung cancer, chronic bronchitis, were incomplete; 5 were identified as emphyseme, etc.This is because smokers with a high consumption of tuberculosis in the USSR is now less of tobacco for many yearaj 3 of the car- a problem partly due to improvement cinomas were identified as anaplaetic, in living conditions and partly to 1 epidermoid, and 1 cylindrical. improved treatment methods. On the other hand, lung cancer, shronic bronchitis and other diseases of the C 11868 respiratory organs are increasing, Lange, D. and Plagmann, H.-C. though not to the same extent as in other DIAONOSTIK UND THC.RAPIE VON ZUNGEN- countries. VERANDERUNGEN UND ZUNOSNERKRANKUNGEN. (DIAGNOSIS AND THERAPY OF TONGUE ALTERATIONS AND TONGUE DISEASES.) C 11875 Internistische Praxis 9(1):101-16, Peterson, B. Ye. 1969, German (AVF77--- IlYT1411POWSWATNICAAriyaioPAM The most important and most arKoro. frequently-occurring conditions PUTT PROFILAKTIKI I LECHENIYA RAKA and diseases of the tongue were LEGKOOO. (MEANS OF PROPHYLAXIS covered, including tobacco-linked AND TREATMENT OF LUNG CANCER. emokerts tongue, black tongue, leu- Klinicheskaia Mediteina46(12i33-10, koplakia and carcinomas. Dec 1968, AussiierrATE7)

After a brief review of some of thn C 11869 findings reported in the literature on Cattan, A. the caroinogenicity of substances com- CANCEROLOOIE. (CANCEROLOOY.)Vie monly found in the atmosphere, including Medicale 50(4)1369, 371-2, Jan rgrv, the components of tobacco smoke, measures nrarrAbs.) recommended in the USSR for the prevention of lung cancer are outlined. Advances in cancerology in 1968 These measures are mainly directed were briefly reviewed. Theae include to controlling air pollution but also topics such ae: role of the cell mem- recommend discontinuation of smoking. brane and lysosomes; carcinogens in inducing immunization; mechanism of viral action; study of tumoral growth; C 11890 role of lymphatics and ganglia; bio- Friedell, G. H., Burney, S. W., Bell, chemical tests for the detection of J. R., and Soto, E. cervical cancer; scintigraphy by PATHOLOGY AS RELATED TO TRYPTOPHAN radioactive isotopes; utilization of METABOLITE EXCRETION, OCCUPATIONAL labeled molecules; mercury 197 fixation HISTORY, AND SMOKINO HABITS IN PATIENTS in growing tumors; chemotherapy in- WITH BLADDER CANCER. Journal of the volving use of hydroxyurea, hydroxy- National Cancer institUrinTrOTOS=6, urethane, rubidomycin or daunomyoin, Jul 196g. cytosine arabinoside, and 1 -asparaginaae; better methods of administAticn based on better knowledge of cellular cycles; C 11894 and immunotherapy. Hitoeugi, M. EPIDEMIOLOGICAL STUDY OF LUNG CANCER WITH SPECIAL REFERENCE TO THE EFFECT OF AIR C 11874 POLLUTION AND SMOKING HABIT. Bulletin Rabukhin, A. Ye. of the Institute of Public Health 17(3)t TE7=5E, Sep 196g. !VIMWrEITALMA0111334ATPWI rerTMON.OH. purr INTERGRAT3II PTIZIATRII I C 11903 PNEVMOLOGII. (PATH OF INTEGRATION OP Lee, A. M. and Fraumeni, J. F., Jr. PHTHISIODOnY AND PNEUMMOOT.). ARSENIC AND RESPIRATORY CANCER IN MANr Klinicheskaia Mediteine 46(121J135-9, AN OCCUPATIONAL STUDY.Journal of the Dec 19C8, Russian (Abs.) National Cancer Institutg-argTtrZkg72, A case is made for the merging in Tag. the USSR of the medical speciality relating to tuberculosis with the C 11904 specialities relating to all other Martinez, I. diseases of the respiratory organs. e.g. FACTORS ASSOCIATED WITH CANCER OF THE

142 1

C 11904 (continued) C 119',?5 (continued) ESOPHAGUS, MOUTH, AND PHARYNX IN PUERTO months from the early favorable RICO. Journal of the National Cancer cl!Agnosis followed by operation made Institut6721111TOM94, Jun 1969. hardly, if any, difference from a ne- glected malignant carcinoma. In some instances, it has been noted metastasis C 11906 ie rather promoted by surgery. Cu:Tent Daniels. , n., Chokroverty, S., and Barron, knowledge is illustrated by 5 clinical X. D. cases on this point.The distribution of THALAMIC U. 'TION, DEMENTIA, AND carcinoma among the sexes, the time SEIZURES. Arc".o,1 Neurology 21(1)t factor, age, anamnesis, post-operative 15-24, Jul rejgr sunqval, and lymphsdenoma metastasis ar) also tabularly presented.

C 11908 Friedmann, I. C 11930 CANCER OF THE NASOPHARYNX. Proceedings Andi, N. of the Canadian OtolaryngologicaI A PROPHYLAXIS ES POSTTHERAPIAS OONDOZAS STOrgyrntrn, 1988. A HAKEILENES KU2DELEMBEN. (THE PRO- PHYLAXIS AND POST-THERAPEUTIC CARE IN THE STRUGGLE AGAINST CANCER.) Magyar C 11912 On!zolo ia 12(4):249-54, Dec 19W---- Hinder, R. A. and Schmaman, A. 11176gar an (Abs.) BILHARZIASIS AND SQUAMOUS CARCINOMA OF THE BLADDER. South African Medical Journal The progress since 1951 for the early 43(21)s6177Irrgarg4,"T9697 decoction, prevention and methodology of owner ie discussed. The prophylaxis fo, bronchial carcinoma normally should C 11915 be the termination of smoking. The Bryson, O. and Bischoff, F. broad spectrum (cytology, colposcopy, THE LIMITATIONS OF SAFETY TESTING. et:.) screening tests for women over 30 Progress in Tumor Research am)unted to 450,000 cases performed by 19E89xperimental oncologists. In 1987, 317,000 investigations were carried out by gynecologists. The success in prophylaxis is reflected C 11920 by the methodology applied as well as in Orinspan, D., Abulafia, J., Diaz, J., and the maintenance of a network covering all Berdichesky, R. the spectrum of hygiene where cancer may MELANOMA OF THE ORAL MG:OSA. Oral originate. The periodontist and the Surgery, Orel Medicine, and Oar-Pathology, stomatologist should be equally alert and 28(1):1-177-7Ui1V6D. their anamnestic records should be coordi- nated to establish the susceptibilities and the latent caaes for nation-wide C 11925 screening. Specific attention should be Imre, U. directed to hazardous profess::ns, i.e. AZ OPERALT TUDOCARCINOMAS BETEOEK workers in the gas, asbestos, rubber, and PROGNOSISA. (TNE PROGNOSIS OF PATIENTS other industries that art, so-to-speak, UNDERGOING PULMONARY CARCINOMA incubators of cancer.Concerted effort to SURGERY.) Orvosi Hetila 110(1T dsvelop a universal test for cancer detec- 817-22, Apr737r9 , ungarian Abs.) tion, thus far, has not been successful and at some gastroenterological institu- Polmona.7 cancer is a mortal af- tions the efforts are too scientific to be fliction. In the study of 520 patients, of practical significance.The post- it has been established that the prognosis thorapeutio care in the struggle against in women patients is rather worse than in cancer to ae important as its prevention. their male counterparts, though the In the domain of post-therapy the long affliction is more common among male sub- range cooperation of the various scientif- jects. Surgical complications and dif- ic disciplines se well as the collegial ficulties are more common for patients, tact among the experts in their various without regard to sex, under the chrono- splcIalties Si essential. The frequency logical age of 50. In terms of surgery of post-therapeutic care can have a and successful recovery, the incidence of definite psychological impact on the peripheral tumors which have not yet initiated metastasis of the lymphadenoma are the most favorable.This type Of tumor is relatively easy to diagnose, but the prognosis is improved only if surgery ie immediately effected.A lapse of six

143 1 11 C 11947 C 11957 Huong, B-Q., Buu-Hoi, N. P., Duong, Coury, Ch. and Thibault, Ph. P-N., Te, N-H., and Hoang, D-D. L'ACTUALITE FNEUMOPHTISIOLOOIQUE LES CANCERS DU NASOPHARYNX AU 1967-1968. (PNEUMO-PHTHISIOLOOICAL VIETNAM: Epidemiologie, Aspects TOPICS, 1967-1968.)Revue du Pra- Cliniques, Facteurs Etiologiquee ticien 19(3):275-6, 277:U7,-787W Poasibles. (CANCERS OF THE t89-90, 293, Jan 21, 1969, French (Abs.) NASOPHARYNX IN VIETNAM: Epidemiol- ogy, Clinical Aspects, Possible The more important research on Etioloical factors.)Annales Oto- tuberculosis of the lung, bronchial Laryngologie et de ChiTTWIT- cancer, respiratory allergies of the Cervico-Faciair. ET(4-5):287-78, bronchi, and respiratory reanimation, KPr-May 1969, French (Abs.) was very briefly reviewed. The section on bronchial cancer dealt with metastases An epiiemiological, clinical, and of bronchial carcinoma, causes of death etiological study of cancers of the in the course of cancer, parareoplastic nasopharynx has been carried out in and Schwartz-Bartter syndromes, ana- Vietnam, covering 153 cases, of tomical and surgical studies, polychemo- which 156 were epitheliomaa and 7 therapy, and early diagnosis of bronchial were lymphosarcomas. These tumors cancer. The literature references represent 3.5 percent of all types which merit more detailed analysis were of cancer observed over a period of cited. three years, or approximately 3.6 cases per 100,000 inhabitants per annum; these statistics are very C 11960 similar to those recorded in other Lutte Contre Cancer. non-Chinese populations of the Indo- LE CANCER DANS LE MONDE. L'jffensive chinese peninsula (Thailand, Malaya). Contre le Cancer. (CANCER IN THE WORLD. The incidence of nasopharyngeal cancer The Offensive Against Cancer.) Lutte among the Vietnamese is distinctly Contra Cancer 45(172):39-42, Sep:M-- lower than among the Chinese, but 198g; liliFFE-(Abs.) much highor than in peoples of the white race, the Japanese, and the Nikolai Blokhine, director of the Indians. Our observations support Institute of Experimental and Clinical the genetic hypothesis for the etiology Cancerology (U.S.S.R.) was interviewed. of these cancers, and a cocarcinogenic He stressed the importance of the virus influence of certain exogenous factors as the chief factor in carcinogenesis. is postulated. From the clinical Externally, carcinogsAic substances aspect, the neurological complications were the chief accomplices and inter- were particularly significant. nally, hormonal disorders. Soviet (Author Abstract) research In developing immunity against virus-induced tumors was encouraging. Research in the pollution of air, water, C 11950 and soil was also being conducted in Picha, E. the Soviet Union. In regard to tobacco, RADIUMNEKROSEN UND NIKOTINABUSUS. he emphasized the necessity of early (RADIUM- CAUSED NECROSIS AND NICOTINE detection and treatment of pre=cancerous ABUSE.)Wiener Klinieche Wochenschrift states since, as he believed, cancers 81(14):265717rpr 4, 1969, German (Abs.) generally do not develop in healthy tissues. Therapeutic measures in the A possible connection was seen treatment of tumors in the Soviet between nicotinism and the incidence of Union include hormonal treatment, where severe radium-caused necrosis of the applicable, and the regional treatment portio and vagina which can occur in of tumors by direct injection of large the radiation therapy of neoplasms of quantities of the agent directly into the genital area of women. Observation the tumor. Treatment of deep-seated of 48 women (39 of Whom were listed es tumors as of the lung, esophagus and heavy cigarette smokers for et least stomach was difficult since such tumors eight years) appeared to support this could not be diagnosed promptly. This contention. The vascular changes caused interview was reproduced from the Soviet by nicotine were viewed as an unfavorable publication, "Novosti". factor in the necrosis.

144 )4% C 11962 C 11963 (continued) Zapletal, J. either from mechanical or immunological KLINICKE ZKUSEVOSTI S DLOUHODOBOU influences. In other fields, on the CHEMOTERAPII SPINOCELULARNIHO DRONCHO- contrary, the radioactive contents are GENNIHO KARCINOMU. (CLINICAL EXPERI- very likely to play a part. (Author ENCE WITH LONG-TERM CHEMOTHERAPY OF Abstract) SpINOCELLULAR RRONCHOGEWIC CARCINOMA.) Casopis Lekaru Ceskych 108(23):688-90, 1964, Czech (Abs.) C 11964 Nunez, I. p., Elverdin, J. M., Olivares, The author summarizes his experience M. A. and Caffe, P. 3. with long-term continuous chemotherapy CANCER DEL LABIO. (CANCER OF THE LIP.) with cyclophosphamide in 30 patients Revista Argentina de Cirugia 15(3-4): with inoperable apinocellular broncho- 7r=r,--Kep-Cct, I96T7 pan s (Abs.) genic carcinoma and compares the results with an equally-sized group of patients A series of 51 patients with cancer treated by symptomatic therapy.The of the lip treated by surgery during a selection of both groups was such that period of 20 years was analyzed. The patients born in odd years were treated lesion was extirpated In all the with cyclophosphamide and patients born cases; dissection of the gland was per- in even years formed the control group formed in 17. In 3, histologic atudy subjected to symptomatic treatment. of the apecirens revealed gland metas- The diagnosis of carcinoma was checked tasis. Long-term evolution is known morphologically in all patients. In in 34 patients; 50 percent are olive the group of patients subjected to and in good condition 5 years after long-term therapy with cyclophosphamide, operation. Corm.: nts were made on the so far the period of survival was by general characteristics of the series. 286 days longer than in the control group. Therapeutic tactics applied and the A favorable objective effect of treatment procedures used were described. was recorded in 40 percent, subjective (Author Abstract) improvement in 36 percent. So far the everage period of chemotherapy was 330 days. (Author Abstract) C 11965 Ott, A. and Titscher, R. DAS PRIMARE DOPPELKARZIFOM DER LUNGE. C 11963 (THE DOUBLE-PRIMARY CARCINOMA OF TRE Vidal, J. and Michel, P. 8. LUNG.) Fortschrltte auf dem Gebia te INCIDENCE DU CANCER BRONCHIQUE CHEZ LES der RontiFigt-FERTMurladiF-NaTMF: MINEURS DE CHARBON. RESULTATS D'UNE FINizin1-10j6):/93-9,Turr9ggrreTman ENQUETE SUR LA CONSOMMATICN DE TABAC. Ina.) (INCIDENCE OF BRONCHIAL CANCER IN COAL MINERS. RESULTS OF AN INVESTIGATION ON The authors report seven cases cf THE CONSWPTICN OF TOBACCO.) Journal primary double carcinomas (five simul- Francais de Medecine et Chirlff---- taneous and two successive). In six TE3Waguea 23(1):49-MUTE 1g patients one of the carcinomas pre- French (Abs.) sented es round shadows, in some Cft800 with cavitation and in others Without. Several notions are first objectively In one patient both primary carcinomas analyzed, as they are based on surveys showed cavity formation.They stress of very different concepts. Our survey the significance of primary round shad- shows that a fall in the incidence of ows in the diagnosis of double carcino- bronchial cancer has little to do with mas. The best therapeutic results are a smaller consumption of tobacco by obtained by surgery if the tumors are coal-miners. The more recent works on still operable. If they have become the subject show that there is no inoperable, the treatment of choice is clear-cut answer to the question as to irradiation with high energy X-rays or whether there is a relation between fast electrons. (Author Abstract) bronchial cancer and anthracosilicosis. This relationship varies from one country to another and from one region C 11966 to the other. It varies with the Rojas, L. L., Lescaille, E. B., Garcia, geological features of the coal-basin E. B., and Hernandez, L. J. under study, and those features are ESTUDIO ANATOMOCLINICO RADIOGRAFICO DE ems now aeldom properly set up in the CIEN CASOS DE NEOPLASIAS PLEUROPULMON- resulting accounts. In some coal- ARES PRIMITIVAS. (RADIOGRAPHIC &NA- fields, the dusting seems quite unim- TOMICOCLINICAL STUDY OF 100 CASES QP portant as to the incidence of bronchial PRIMARY PLEUROMILMONARY NEOPLASMS.) cancer, or it appears to inhibit it, Revieta Cubans de Medicine 7(3):273- $77-17i ST-111537 sTiTalarubso

145 '49 C 11966 (continued) C 11969 (continued) peated hemoptysis, an exploration of the One hundred cases of primary pleuro- systemic circulation can explain its pulmonary neoplasm were reviewed during production and lead to measures to avoid the period from April 7961 to December a possible cataclysmic hemoptysis; the 1964, In ',he "Hospital Oeroral Calixto high incidence of vascular thrombosis in Garcia". Pa.thological studies were the course of the evolution of the tumors carried out in all cases. The mascu- suggests the systematic use of prolonged line sex prevailed over tho feminine anticoagulant treatment in these pa- sex and there was high incidence among tients; the high incidence of hypoxia the smokers. The whole analysis or suggests a possible oxygenation in asso- the etiological factors such as age, ciation wit): medical or physical treat- sex, race and tobacco did rot show any ment; and the nossibility of repermeation important variation with regard to the of pulmonary arteries in case of obtuva- histological appearance of each particular tion by compression if proved reversible. type of group. It is of importance to point out that in 28 of 30 cases of undifferentiated trmors, the diagnosis C 11970 can be established following the Liebow's Lutte Contre le Cancer. outline. A comparative stuffy with CHIMIE. ENTRETIHN AVEC LE PROFESSEUR other national and foreign staCistics N. P. BUU-HJI. (CHEMISTRY. CONVERSATION was made and the necessity for a greater WITH PROFESSOR N. P. BUU-HOI.) Lutte diffusion in our country of massive Contre le Cancer (351 Special 01175h)1 radiographical examinations to detect 377117-1758, -V7FiTch (Ate.) the neoplasm at early stages was stressed. (Author Abstract) Dr. Buu-Hoi discussed the fruitful cooperation of chemiste and epidemiological ctinicians in identifying the nature of C 11968 cancer and the measures for prophylaxis. Favez, O., Maillard, J.-M., and Willa, C. Two examples of such cooperation were LES METHODES D'EXAMEN EN FNEUMOLOOIE. cited: (1) the discovery that aromatic (EXAMINATION METHODS IN PNEUMOLOGY.) hydrocarbons in soot were responsible for Revue Medicale de la Suisse Romande certain occupational cancers in chimney Err:97-107, Te66 r;677-Pilich (Abs.) sweeps, and (2) that cartain toxic substances in foods were responsible for Diagnostic procedures for the cancers of the liver.A chemical struc- detection of malignant and ronmalig- ture, identified as 5,4:9,10- nant states were discussed. The dibenzopyrene, wee presented as the most malignancy of lung opacities was carcinogenic substance in cigarette especially suspect if the subject smoke. Viruses were also mentioned as was a heavy striker above the age of the cause of cancers but the complexity 45 years. Emp,,ysema was especially of their structure and function still suspect in male smokers in their escapes precise analysis by chemists. sixties having other clinical signs Buu-Hoi also commented on his current of the disease. research and the future aims of cancer research.

C 11969 Laval, M. P. C 11971 MODIFICATIONS DE LA CIRCULATION PULMONAIRE Portman, U., Bisch, X., and Parcits, P. AU COORS DES CARCINOMES BROW:HIqUES PRIM- LA MALADIE CANCEREUSE EN OTD-RHINO- ITIFS ET LEURS CONSEQUENCES THERAPEU- LARYN00/001E, (CANCER IN OTORHINO- TIQUES. (MODIFICATIONS IN F.ILMONARY LARYNOOLOOY.) Revue de lar olo to CIRCULATION IN THE COURSE OF PRIMARY OtologLie-FthinolFre-971 BRONCHIAL CARCINOMAS ANDna(iTHERAPEUTIC Jan-Feb 1967, French (Abs. RESULTS.) Bulletins et Memolres de la Societe MediWM-alF. TOram-an-1m' The writers stress the recrudes- 1199-1:7135:11)1779E87 renc cence of delayed recidivation of cancers in the realm of otorhinolaryngology. In Findings by means of anatomicopatho- reality, it does not, for the most part, logical, angiogrsphic (including scinti- concern recidivations or metastases, but graphic), and physiopathological tech- a new tumor. This fits in well with the niques were received. The analysis of modern concept of the viral origin of the exploration of circulatory modifica- cancer, sad the authors review the latest tions led to the following conclusions: research carried out concerning this sub- Data from pulmonary angiography permit a ject by emphasizing the fcct that during better definition of the tuscral volume the last eight years almost all the and of the environment; in case of re- oncogenical viruses known have been

146 'so C 11971 (continued) C 11998 identified morphologically in the in- Schmidt, S. fected cells. Certain viruses develop IS IT STILL POSSIBLE TO CHANGE THE TOTAL in the nucleus, others in the cyto- TOXIC SITUATION? yi.4212 Medical Journal plasm, and finally others on the cell 18(8):311-21, Mar surface. The virus is therefore the origin of a general disease, the cancerous disease whien. otst be considered C 12002 more and more as the result of a reel Mital, V. P. and Gupta, S. opposition between the aggressive THE STUDY OF A B 0 BLOOD GROUPS IN ORAL potential of the disease and the CANCER. Indian Journal of Cancer 6(1): organism's means of defense.The %u- 34-7, Mar"i9677 thors also give some typical exawles with the aid of observations of cancers or the larynx and or the deep regions C 12003 of the face. They etraaa especially the Jussawalla, D. J. aid Bhaneali, S. K. pulmonary metastases in cancer of the CANCER IN THE TOP4S. A Comparative larynx which appear to be becoming more Study with Speclul Reference to India. numerous.After giving the modern Indian Journal of Cancer 6(1):1-26, methods of investigation, both for the nrrinr7 larynx and for the lungs, they believe that it is indispensable to submit all patients suffering from neoplastic C 12006 laryngeal disorders, whether they under- Kreyberg, L. go an operation or are treated by radium, AETIOLOGY OF LUNG CANCEF, A to a systematic and regularly renewed Morphological Epidemic,' !'cal and examination of the lungs. Experimental Analysis. uslo, Norway, Universiteteforlaget, 1969, 90 pp.

C 1197E Dudley, E. F., Beldin, R. A., and Johnson, C 12006 B. C. Price, J. M. CLIMATE, WATER HARDNESS AND CORONARY NONINDUSTRIAL CHEMICALS AS ?OSSIBLE HEART DISEASE,Journal of Chronic FACTORS IN THE ETIOLOOY 01 BLADDER Diseases 22(1):2573177Ur17577--- CANCER. Journal o' tr lational CancerIniitilTr 43(1172§7-471111969.

C 11979 Chattopadhaya, M. L., Mittel, M. M., Bhatt, C 12008 V., Bhargava, S. p., and Sharma, M. L. Bapna, B. C. Singh, S. M., and Nath, A. STUD1 OF SOME OF THE FACTORS IN THE URINARY EXCRETION OF CARCINOGENIC EFTUEMIOLOGY OF CORONARY HEART DISEASE TRYPTOPHANE METABOLITES IN CANCER OF IN DELHI AREA. Journal of the Indian BLADrER.Indian Journal of Medical Medical Association 52(M31$9:157-X177 Reseateh577M-887171Wr-T9= 1, 1969. C 12014 C 11980 Sturgis, K. R. Wheeler, W. L., Jr. and Ayre, J. E. IS SURGERY FOR LUNG CANCER lORTHWHILE/ CANCER DETECTION AND FREVENTION IN Bulletin of the Geisinger Medical Center DOUSTRY. (Editorial). Cancer 2173111 IO27Tug196g. Cytology 8(2)17, Jul-Des TM. C 12016 C 11984 Ashley, D. J. B. and Davies, H. D. KleitsAi, W. P. end Tericco, A. LUNG CANCER IN WOMEN. Thorax CANCER AND LEUKOPLAKIA OF THE LIP, 6400:446-50, Jul 1969. Nebraska State Medical Journal 54(7)1 4117707-41-Tg677----- C 12017 Mason, M. K. and ordan, J. W. C 11989 CARCINOMA IN SITU AND EARLY INVASIVE Harrison, D. F. N. CARCINOMA 07 TREBacmcmys. Thorax CARCINOM/ OF THE LARYNX.British 24(41461-71, Jul 1969. Medical Journal 2(5657):61571777,n 7771§117.

117 C 12019 C 12107 (continued) Kidner, P. H. and Williams, H. O. WORKERS. Jo al of the National Cancer BRONCHIAL CARCINOMA IN A YOUNG NEGRO. Institute nrJUl 1969. Thorax 24(4):472-5, Jul 1969. C 12120 12025 Bowlin, J. W. Stewart, T. H. M., Klassen, D., and PRIMARY CARCINOMA OF THE LUNG: PREVENTION, Crook, A. F. DIAGNOSIS AND TREATMENT. Joli,rnal of the METHOTREXATE IN THE TREATMENT OF Misaissi i State Medical T%-rirentreirinf MALIGNANT TUMOURS: Evidence for the 20 - ,airrgo. Possible Participation of Host Defence Mechanisms. Canadian Medical Association Journal 101(4):191-9, C 12125 rug-2171969. Le Roux, B. T. BRONCHIAL CARCINOMA. Edinburgh and C 12035 London, E. & S. Livingstone Ltd., Hertel, 0., Louhija, A., and Konttinen, A. 1968, 144 pp. CARDIOVASCULAR STUDY OF 100 CHRONIC ALCOHOLICS. Acta Medica Scandinavica 185(6):507-137Nn-193177 C 12128 Huber, F. B. DIE KLINIK DES ADENOKARZINOMS DER C 12035 BRONCUEN UND DIE OPERATIVEN Karuga, W. K. SPA7SROEBNISSE. (THE CLINIC OF LUNG CANCER IN KENYA East African ADENOCARCINOMA OF THE BRONCHI AND THE Medical Journal 46(4):7r=g,XtriV69. OPERATIVE CONSEQUENCES.) Thoraxchirurgie VaskularChirui ie 17(4)):334 -41, Aug- rg317arma s.)

C 12103 By analyzing 70 cases of our own Parkes; H. O. and studying the literature, we investi- EPIDEMIOLOGY AND ETIOLOGY OF HUMAN gated the causes for the unsatisfactory BLADDER CANCER: OCCUPAT:ONAL BLADDER long term survival rate of patients CANCER IN THE BRITISH RUBBER INDUSTRY. whose adenalarcinoma has been resected. Journal of the National Cancer Two years after resection 68 percent of fliTirrarir(T)1741P5273b-rIT69. the radically and 83 percent of the palliatively operated had already died. Of the 37 patients who showed pulmonary C 12104 symptomatology, only two lived longer Koss, L. O., Relined, M. R., and Kelly, than five years after resection.This R. E. points toward the early hematogen FURTHER CYTOLOGIC AND HISTOLOGIC STUDIES dissemination of the adenocarcinoma. OF SADDER LESIONS IN WORKERS EXPOSED However from 10 patients without symptoms TO PARAAMINODIPHENYLs PROGRESS REPORT. whose generally good state and apparent Journal of the National Cancer institute stationer, 4n ',salon did not prohibit

rstrre153-437-JurraTT tnoratotoix, , lived longer than three years and 3 longer than five years.The thoracotomy in the phase °V coin lesion C 12106 without apparent symptoms fa therefore Ferber, K. H. decisive for the chance of survival of INDUSTRIAL BLADDER CANCER: A PROGRESS patients with an adenocarsinoms of the REPORT AND SVNE UNANSWERED QUESTIONS. bronchi. (Author Abstract) Journal of the National Cancer Institute r);(i7174g8;Turing C 12129 Candiori, R. and lonescu, M. C 12106 CUNOSTINTE NEC:MARE PLNTRU RROPILAXIA Munn, A. CANCERULUI BROMOMMNAR. (KNOW- ASSESSMENT OF INDUSTRIAL BLADDER CANCER LEDGE REQUIRED FOR THE PROPHYLAXIS OF HAZARDS PROM EXPERIMENTAL DATA. Journal BRONCHOPULMONARY CANCER.) Wm* of the National Cancer Institutearm Sanitara (2)05-9, Feb 1969Marian rsinr,Jul 1969. tabs./

The rectors incriminated in favoring C 12107 the onset of bronchopulmcoary cancer Veys, C. A. are reviewed. Among the living and TWO EPIDEMIOLOOICAL INQUIRIES INTO THE working conditions, the authors discuss INCIDENCE OP BLADDLR TUMORS IN INDUSTRIAL the role of air pollution of nocuous

141 C 12129 (continued) C 12169 occupational elements (nickel, chro- Alarcon, D. G. matee, crude all, radioactive sub- RATIONAL APPROACH TO THE PROBLEM OF etancea etc.) and smoWang. Certain dis- CANCER OF THE LUNG.Geriatrics 24(9): easee of the bronchial trunk, 106-14, Sep 1969. especially chronic bronclitie, likewise predispose to malignant neoplasia. The relationship between pulmonary viral C 12170 diseases and neoplasms is quescionxble, Mehta, F. S., Pindborg, J. J., Vaftary, since according to some authors viral D. K., and Gupta, P. C. diseases do not favor cancer, but, in ORAL LEUKOPLAKIA AMONn INDIAN VILLAGERS. opposition, the latter favors the The Association with Smoking Habits. former.To conclude, stress is laid on Britiah Dental Journal 127(2):73 -7, Jul the importance of mass detection of 15, 1969. bronchopulmonary cancer in the early etages, especially by means of microroentgenovame. (Author Abstract) C 12177 Zegarelli, E. V., Kutscher, A. H., Cohen, D. W., Ketcham, A. S., Ochoa, M., Jr., C 1211) and Stanton, G. Akem, G., Depierre, A., and Brocard, H. MAINTAINING THE ORAL AND GENERAL HEALTH LE CANCER BRONCHIQUE PRIMITIF AVANT OF THE ORAL CANCER PATIENT (PART TWO). QUARANTE ANS. (PRIMAI7Y BRONCHIAL CA 19(4):232-47, Jul-Ag 1969. CANCER BEFORE THE AGE OF FORTY YEARS.) Semaine dee Hopitaux 45(31-4):2146-54, 7071W97-PrenEh (Abe.) C 12194 Garza Garza, R. A. and Moreno Torres, A. Primary bronchia) carcinc.14 before CARCINOMA DE LARINGE. Comunicacion the age of forty is rare but not ex- Preliminar. (CARCINOMA OF THE LARYNX. ceptional as it represented 5.6 per- Preliminary Report.)Revista Medica cent of the cases in our series, i.e. 7(e):509-15, 195P, Spanish lAbiT7T--- 17 cases out of 303 observed over a period of 12 years.Certain special One hundred and twenty-five cases were characteristics are worth emphasizing: observed between May 1961 and April 1966. the high percentage of cases diagnosed Laryngeal cancer occurred most frequently on roatine X-ray (23 percent), the high in the fifth, sixth, and seventh decades proportion presenting ae acute of life, with males predominatinc in a pneumonia (23 percent), and the 1011 ratio.Tooacco and alcohol appeared relatively large number with metaetases to favor the origin of such cancers. when first seen.This disease always Surgery was the method of choice in the has a very poor prognosis, but even early clinical stages. In extracord though they are rare, the number of lesions, and in the presence or absence cases surviving more than 5 years of clinical metastasis to the neck with- following surgery should be noted. out general mataatasis, treatment of This cancer, °serving in young sublects choice was total laryngectomy with con- very often ia good general health current radical dissection of the neck. should be treated simultaneously by Damage resulting from radiotherapy vas all modern methods including surgery, c;enerally attributedo pmgressively radiotherapy, antinnoplastic agents, treated lesions. Prognosis was better in and even immunologic agents.The direct ratio to the early stages of the real problem In such patients is the lesions. In the cased under discussion, constitutional factor which allows the radiotherapy-surgery sequence gave tumors to develop so early; to resolve the best results. it, it will be necessary in the future to investigate further the immunologic factors responsible. (Author Abstract) C 12199 Thiess, A. M., Oettel, R., and Uhl, C. BEITRAG ZUR PROBLEMATIN BZRUFSBEDINGTER C 12152 LUNGENKREBSE. Langzeit-Bcobachtungen Zsgarelli, E. V.Kutscher, A. H., Cohen, Aus der Badischen Anilin- & Soda-Fabrik Y. V., Ketcham, A., Ochoa, M., Jr., snd AG In Ludwigshafen am Rhein Zweite Stanton, G. Miti,i1u7g. (THE PROBLEM OF LUNG CANCER MAINTAVING THE ORAL AND GENERAL MALTH r DUCED BY OCCUPATION. Long-term OF THE ORAL CANCEL: PATIENT (PART TWO). Observations at the Badische Anilin-& U. S. Department of Health, Education, Soda-Fabrik AO at ltdwigehafen am and Welfare, Public Health Service, Rhein, Second Report.) Zentralblatt Washington D.C., Public Health Cervics fur Arbeltsmedizin and ArbeitesChutz Publication No. 1958, Jun 1968, pp. 5+- TTT41/97-115, Apr 1117*, German (Abs.) 67. C 12199 (continued) C 12244 (continued)

Lung cancer observations for an Statistics are presented on various eleven -year period, in a caemical carcinomas classified according to the factory in Ludwigshafen, Germany, are 1958 Geneva International Classification. presented. Industrial personnel were Data are discriminated by occidential or grouped into four categoriesi lock- oriental background of the cancer emiths, operators of the nickel victims, and the carcinoma types are tetracarbonyl plant, operators of the listed by country of origin of the eulfuric acid plant, and workers in immigrant groups.Certain carcinomas all departments where dimethyl sulfate show unusual features.For example, in is an important reagent.A total of 51 the case of thymid carcinoma the portion locksmiths contracted lung cancer, but of women afflicted in larael is unusually it is quite difficult to pinpoint a high, and the incidence of lymphatic and connection betheen occupation and this hematopoietic system carcinomas, health hazard, as workers in 23 including leukemia, is rather high for different shops or departments were all age groups. Death due to skin subjected to differential attacks upon carcinoma is rare, and oriental ancestry their respiratory systems. Also, the accounts for the major incidence. For relationship of this incidence with the bladder carcinoma, the exceediAgly small number of cigarettes smoked is nebulous, number of women afflicted is striking. since the 51 workers included non- It is r. ,t possible to compare the smokers, moderate-to-heavy smokers, etiology of kidney carcinoma with its occasional smokers, and smokers who had etiology in other countries, at published quit the habit. Most locksmiths had international data are lacking. It can lung cancer diagnosed at age 55 to 65. only be said that it affects almost Nickel workers rarely show lung carci- exclusively European immigrant groups and noma, but rather nose- and bronchial that kidney carcinoma has greatly in- carcinomas, apparently caused by creased during the last 3 yeara. nickel duet. The type of cancer attacking sulfuric acid plant workers is generally bronchial cancer. Any C 12206 evaluation is practically impossible, Schamaun, M. since workers were in contact with duet DIE AUFGABEN DER CHIRURGIE AM BEISPIEL containing pyrite combustion products DER THORAXCHIRUROTE. (THEPROBLEMSOF for many years.Arsenic and chromium SUROERY.,USINO THORAX SURGERY AS AN have been known as causative agents EXAMPLE.) Praxis 58(1)1391-7, Apr. for carcinoma in inivatrial workers. 1969, Oersarrnir.) In recent years dust protection for workers improve: and the method of Chest surgery has been performed suc- processing pyrites has changed.As for cessfully in hospitals only recently, lung caner in workers of sulfuric acid and reports have appeared in literature plants, the incidence in smokers is since 1917. Since its inception in 1883, greater than in nonsmokers.Regarding this technique was not alwaya aucceseful. dimethyl sulfate, it can be said that A poeumonectomy was reported in 1931, and the oaterial, as such, is toxic, but segment resections have been undertaken not a carcinogen. Since it introduces since 1943. Many types of thorax a methyl group into many chemical surgery became possible only after compounds which are carcinoma, its certain drugs like streptomycin were presence may increase the incidence of synthesized to assist the surgeon in his all carcinomas of entirely different work. This surgical evolution has etiology. continued tmtil now bronchial carcinoma is perhaps the one disease in which thorax aurgery ie indicated, even though C 12204 the .actual intervention ie exceedinhly Kellner, G. complicated and actually often cannot DIE EPIDEMIOLNIE DES KARZINOMS (II). even be attempted. In a 5-year observa- Eine Untorsuchung an Hand von tion, only 5 to 8 percent of the persons Isrlelischem Zahlenmaterial. (THE undergoing surgery really recover.The EPIDEMIOLOGY OF CARCINOMA (ii). An procedure to replace a complete trachea Investigation Based on Numerical Values ie nehulous :t the present time, and the from Israeli.) Medizinische Welt solution to the problem of transplanting ('.8):1069-79, May 34 1969, German complete lungs lags far behind solutions (Abe.) for transplanting hearts, kidneys, end livers. Guidelines are nct too helpful

150 154 C 12206 (continued) C 12224 (continued) as to when chest surgery ie to be CARCINOGENIC SUBSTANCES. Revista attempted and as to how the surgeon Medico-Chirur icala 72(2 :277=517 should collaborate with ',thole in the pm-nn , umanian (Abs.) medical profeasion.Tobacco smoking is mentioned as something better avoided The role of arsenic, asbestos, by patients. chrumium, iron, nickel, beryllium and their derivatives in producing cancer in humans is discussed. Arsenic is C 12212 considered to be directly related to Oettel, H., Thicer. A. M., and Uhl, C. cancer in the skin, lunge, liver, and BEIIRAG ZITR PROLAMATIK BERUFSBEDINGITR sinus. Workers in the glace and arsenic LUNCENERBBSE. (CONTRIBUTION TO THE industry, and those employed in PROBLEM OF OCCUPATION-LINKED LUNG horticulture and viticulture are CANCER.) Zentralblatt fur affected mostly by arsenic and its Arbeitsmedizin and Arbeirischutz compounds.For example, mortality due 1111=7215T73133,75Et1958, German (Abs.) to bronchial cancer wee found to be 5.13 percen for people engaged in horticul- Long-term observations (1912 -1967) ture compared to only 0.97 percent for of lung cancer incidence in a German the rest of the population.Arsenic le chemical factory are compared with also found in cigarette paper. Non- statements in medical literature. The smokers inhale 0.5 mg. As/year Whereas fact that certain occupations favor smokers inhale 0.5 mg. As/100 cigarettes. specific types of cancer has been However, experiment on the role of known since 1775, when the scrotum arsenic in inducing cancer are not cancer of British chimnersweeps was conclusive.A close correlation wee recognized. Many literature reports found between asbestosis and lung have to be accepted with reservations cancer. The frequency of lung cancer for any occupation engaged in at an due to absestosis is 10 times higher early age and under unsanitary con- than the normal values.Chromium and ditions will lead to different dis- chromatee are cancer producing, especial- eases, including cancer.The fre- ly lung cancer.A study of workers from quency of incidence is discussed for 7 chromium plants in the United Statcs tar carcinomas, bladder cancer, showed that about 21.6 percent of chromate-lung cancerasbestos-lung mortality was due to lung cancer, as cancer, and arsenic-induced cancers. compared with 1.4 percent for the Tobacco smoking can be isolated &a general population.Another study a contributing or causative agent, but reports that mortality due to cancer of sometimes its influence ie doubtful. the lung was 15 times higher for workers Bladder cancers have been observed in engaged in the chromium industry than both smokers and nonsmokers, but for the rest of the population.About Chromate cancer will occur only in 70 percent of cancers occurred at age smokers' lunge. This indicates a 52. The incidence of lung cancer is syn-carcinogenesie which means that high among workers in the iron industry. the carcinogenic materials from to- Experimental work with iron compounds bacco are Joined in their action by showed that 16 out of 45 mice developed the chromate'. In the chemical in- cancer. The role of nickel in cancer dustry it is difficult to ascertain formation is particularly impotrant in whether lung cancer is an occupational England and Norway. In England, nickel disease, or if it was caused by other industry workers exhibited incidences of agents and merely aggravated by the lung cancer and natal cancer which were 5 occupation. Retrospective evaluation ie and 150 times, respectively, higher than difficult since the chemical plant working those of workers in other industries. enviroment has changed.Workers of the Only 3 cases of lung cancer related to chromate department who have teen nickel compounds were discovered in afflicted with lung cancer for the last Norway.There is no nickel-related eleven years might have contracted the cancer in Germany, U. S., and other disease elsewhere.Some workers from this countries.Only 4 cases of cancer due department (which is now closed) are to beryllium were reported.Workers in working in other departments. the beryllium indtstry showed a high incidence of dermatitis and acute- and chronic teonchitis. Reduction of the C 12224 amount of carcinogenic substances and the Zamfir, Oh. time of contact in sanipulating them are SUBSTANTE ANOROMICE C4NCER4GENE IN recommended measures for cancer preven- MEDIUL DE VIATA SI MUNCA. (ENVIRON- tion. Individual safety protection is MENTAL AND OCCUPATIONAL INORGANIC very important in reducing the incidence of cancer in the above industries.

151 155 C 12226 Meinsma, L., van Rootselaar, F. J., Fullmer, C. D., Short, J. 0., Allen, A., Bierateker, K., Bloentergen, H. C. P., and Walker, K. Dumoulin, F. V. B., and Drogendijk, A. C. PROPOSED CLASSIFICATION FOR BRONCHIAL DE FACTOR LUCHTVERONTREINIGING IN HET EPITHELIAL CELL ABNORMALITIES IN THE ROKEN-LONOKANKERVRAAGSTUK. (THE AIR CATEGORY OF DYSKARYOSIS. Acta POLLUTION FACTOR IN THE SMOKING -LUNG CaelogIca 13(8):459-71, Arg-r969. CANCER PROBLEM.) Nederlands Ti,jdschrift voor Genteskunde 11%24'1%1112-8, Jun 177'1666, Dutch (Abs.) C 12261 Meyer, J. S. and D'Elia, J. A. Several authors have commented (in METASTATIC ADRENAL GLAND CARCINOMATOSIS. letters) on an article by A. C. Case Reports. Missouri Medicine 66(9): Drogendijk on the importance of smoking 734-9, Sep 1969. in the development of lung cancer. L. Meinema believed that other factors such as air pollution may predispose popula- C 12265 tions to cancer. F. J. van Rootselaar :Alirago Medicine. noted that people in agricultural areas CHOKING ON AIR.Chicago Medicine smoked less and that city dwellers were 72(17):623, Aug 16, 1969. exposed to more cigarette smoke in addition to air pollution. K. Bierateker stated that although absolute C 12268 values for lung cancer were lower in Vazirani, S. J. and Dalttsch, W. W. rural areas, percentagewiee the increases ORAL CANCER IN WOMEN. Punjab Medical were greater. H. C. P. Bloemberger Journal 18(9):351-7, Apr 1969. stated that smoking studies were inconclusive since city air contained 8 to 11 times as much benzopyrene as C 12269 rural air.F. V. B. Dumoulin mentioned Stone, D. D. and Sturgill, B. C. (Editors) that homes in a certain high-risk area LUNG LESION AND FOCAL NEUROLOOIC SIGNS. were heated by a cheap "house-brand" coal Virginia Medical Monthly 96(9):532-42, which discharged much caroinogenic tep-1967. material to the atmosphere. Motor %,ehicle exhaust gases exerted a greater influence on lung cancer than cigarette C 12272 smoking. In rebuttal, A. C. Drogendijk Cooper, E. H. Anderson, C. K., and agreed that 3,4-benzopyrene and 1,12- Williams, R. E. benzoperylene caused lung cancer in EVOLUTION OF BLADDER CAAER TN MAN. urben areas but stressed that his Proceedings_ of the Floyal Society of atatistica clearly proved that smoking Reoicine 67(87:1=4;-Alrig 1969. was the cause of lung cancer. C 12274 C 12235 Robertson, M. A. Trible, W. M. CLINICAL OBSERVATIONS ON CANCER CANCER OF THE ORAL CAVITY.Five Year PATTERNS AT THE NON-WHITE HOSPITAL End Resulta in 237 Patients.Annals BARAGWANATH, JOHANNESBURG, 1948-1964. of Otolo , Rhinology & Larynerc7V- South African Medical Journal 43(30): TS( Aug 19969. $]T =31, Jul 26, 1969.

C 12239 C 12288 Wolinsky, 3. and Liechner, M. W. Moolten, S. E. NEEDLE TRACK IMPLANTATION OF TIMOR AFTER INDUSTRIAL PNEUMOCONIOSIS IN NEW JERSEY. PERCUTANEOUS LUNG BIOPSY.Annals of Pathologic Manifestations.Journal of Internal Medicine 71(2):369727-K4E-1969. the Medical Society of New Jeraey 661115)155T-6t, Oct

C 12240 Fahy, A. C 12292 LUNG DISEAUE FROM COTTON MID ASBESTOS? Freckmen, H. iS. Asbestos: can This Indispersable WHEN IS CANCER HOPELESS? Cincinnati Substance Cause Physical Herm?Bulletin Journal of Medicine 50(3):69-70, Mar National Tuberculosis Association 550): r7377-- 73-77S715 !Mr

gt, C 12295 C 12361 (continued) Hammond, E. C. The author studied the correlation,be- CANCER PREVENTION AND COMPETITIVE RISKS. 14 pre- Archives of Environmental Health 19(3): tween lung cancer and smoking in fectures in Japan. In 1955 the correla- 395-402, Sep 1969. tion coefficient was +0.36 and in1960, it was +0.16. Consequently there is no significant relation between lung cancer C 12303 Lung cancer should be Mackie, B. S. and smoking. studied not only in relation tosmoking A SKIN TEST FOR CARCINOGENS. tutors Australian Journal of Dermatology but also in relation to other 10(27:97-9,KUirrg6T7 such as air pollution, living conditions, heredity, etc. (Author Abstract) C 12307 Solanke, T. F. CARCINOMA OF THE ESOPHAGUS IN IBADAN. C 12371 International SlaszE 52(3):204-9, Simmons, H. E. In: Simmons, Tep 1969. SMOKING AND CANCER. H. E., The Psychogenic Theory of Disease: A New Approach to Cancer Sacramento, California, C 12309 Research. Raven, R. W. General Welfare Publications, 1966, CARCINOMA OF THE MOUTH AND PHARYNX. pp. 127-41. British Journal of Hoepital Medicine MITOT117ruirl969. C 12374 Schonland, M. and Bradshaw, E. SMOKING PATTERNS IN AFRICANS AND C 12311 Nessif, R. and Harboyan, O. INDIANS OF NATAL. International THE ASAI TECHNIQUE FOR LARYNGEOTOMEES. Journal of Cancer 451:743-51, Journal Medical Libanais22(2):145-51, Mr PIM= C 12375 C 12323 Keller, A. Z. Stoll, P. M. RESIDENCE, AGE, RACE AND RELATED FACTORS CATASTROPHIC HAEMORRHAGE AFTER MAJOR IN THE SURVIVAL AND ASSOCIATIONSWITH American Journal of NECK SURGEFY, British Journal of SALIVARY TUMORS. Surgery 56(7b52T=777urT9177 Epidemiology90(4)7g1777 (:%T13697"

C 12325 C 12386 Castleman, B. and McNeely, B. D.(Editors). Schonland, M. and Bradshaw, E. CASE RECORDS OF THE MASSACHUSETTS CANCER OF THE LUNG IN NATAL BANTU--A A Review of 472 GENERAL HOSPITAL.CASE 37-19691 New NEW CANCER PROBLEM. En land Journal of Medicine281(11): Cases, 1964-1966. South African Medical Journal 43(3177T058-60, Aug - , reyn,1V697-- P3, 1969.

C 12341 Bruno, M. S. and Ober, W. B.(Editors) C 12393 RAPID DETERIORATION SIX YEARS AFTER Bryan, G. T. PNEUMONECTOMY FOR BRONCHOOENIC CAUSATION OF URINARY BLADDER CANCER. CARCINOMA. New York State Journal Acta Urolorca Japonica 15(8)1545-6, of Medicine 6gT7: nn=77;-mt-17 AT11-1469.

C 12404 Rosenfeld, L. and Green, J. C 12361 CARCINOMA OF THE ORAL CAVITY. Journal Onitauka, M. Apnea/TM-- HAIOAN TO KITSUEN NO EKIGAKUTEKI of the Tennessee Medical KOSATSU. (EPIDEMIOLOOICAL STUDY OF 67( 117771:37:117TUYTI697" LUNG CANCER AND SMOKING.) Nippon Kyobu Rineho 25(2) :101 -5, Feb 1965,Japanese 71-57

133 157 C 12409 C 12433 Bruno, M. S. and Ober, W. B. Romer, K.-H. PULMONARY LESION, HEMOPTYSIS, ANEMIA, DAS BRONCHIALKARZINOM IN DER DDR. AND PROORESSIVE DYSWEA.New York I. UBERSICHTSREFERAT. (BRONCHIAL State Journal of M.dicine grain" CARCINOMA IN E. OERMANY. I. 2669-777=3 7.37 ITU= REVIEW REPORT.) Zeitschrift fur Arztliche FortbildtuNg 63(151: VC:grATIg 1, 1969-, -German (Abs.) C 12410 Stanford, R. E. The tollowing topics were reviewed: LARGE-CELL CARCINOMA OF THE LUNG. mortality statistics for bronchial Cancer Seminar 4(2):56-9, Fa'l 1968. carcinoma in men and women in various cities of E. Germany; known carcinogens (including the added risks of cigarette C 12412 consumption) for such tumors; de:air- Bailit, H. L., Ogan, E., and Leigh, R. ability of developing uniform diagnos- ORAL HEALTH OF THE NASIOI OF BCCOAINVILLE. tic and evaluation techniques; appli- Australian Dental Journal 13:353-9, Oct cation and advantages of particular diagnostic techniques; symptomatology and indications for therapy; and the prognosis depending on the symptoms C 12413 and stages of tumors when detected Mehta, F. S., Pindborg, J. J., Gupta, and the therapeutic measures under- P. C., and Daftary, D. K. taken. EPIDEMIOLOGIC AND HISTOLOGIC STUDY OF ORAL CANCER AND LEUKOPLAKIA AMONG 50,915 VILLAGERS IN INDIA. Cancer C 12435 2414) :832 -49, Oct 1969. Klintrup, H-E. VIRTSARAKON KASVAIMET. (TUMORS OF THE URINARY BLADDER.)Duodecim C 12416 64(23)11333-44, 1968, FIERTITTAba.) Wynder, E. L., Dodo, H., Bloch, D. A., Gantt, R. C., and Moore, O. S. The majority of urinary bladder EPIDEMIOLOOIC INVESTIGATION OF MULTIPLE tumors are tumors of the transitional PRIMARY CANCER OF THE UPPER ALIMENTARY epithelium with the histological and AND RESPIRATORY TRACTS. I. A clinical picture varying from benign Retrospective Study. Cancer 24(4):730- papilloma to anaplastic carcinoma. 9, Oct 1969. Betanaphthylamine and certain tryptophan metabolites, including 3-hydroxyanthranilio acid and 3- C 12428 hydroxykynurenine have been Hairston, P. identified as being carcinogenic for LUNG CANCER. CURRENT CONCEPTS IN the bladder.An analysis of a tingle DIAGNOSIS AND MANAGEMENT. Journal cell of sediment is a reliable means of the South Carolina Medial-- of diagnosis. When positive it is ns3EME35E-65TIVIT3F2:77-MT 1969. nearly conclusive; when negative however, it is not significant. Prior to beginning treatment the C 12431 tumor's histological nature and Vie Medicale. clinical spread ere settled upon by TABAC DYSPHONIE.La Dqtection Precoce determining its "grade and 'stage" du Cancer du Larynx. (TOBACCO DYS?HONIA. with the aid of cystoscopy, blopci

1 Early Detection oLaryngeal Cancer.) and bimanual palv.tion performed in Vie Medicale 50(1):30-2, Jan 1969, narcosis. Many different surgical, Finanni7) radiological and chemotherapeutic procedures end combinations thereof The symptoms and diagnoeie of are available for treating tumors of laryngeal cancers were discussed. the bladder. When generally viewed, The association of alcoholiem, heavy no one of these is clearly better smoking, vocal strain, and dental than the other and the outcome of pyorrhea is considered almost certain treatment depends primarily on to result some day in a cancer in the treatment procedure. ORL region.Of this tetrad, only the prevention and therapy of pyorrhea may be easily managed by counseling.Indirect or direct larynaoscopy are useful in the diagnosis of laryngeal cancers but the most certain results are obtained by biopsy.

154 161 C 12452 C 12482 Baron, F. and Gaillard, A. Scott, '4. O. ETUDE STATISTIQUE KIR LE ROLE DU TABAC, NEW CONCEPTS IN CANCER CONTROL. DES BOISSONS ALCOOLIQUES ET DE IA MAUVAISE Preventable and Avoidable Cancers. HYGIENE BUCCALE GONNE FACTEURS ETIOLOGIQUES California Medicine 111(4):245-51, DES EPITHELIOMAS DES VOTES AFRO- DIGESTIVES mrriusr. SUPERIEURES. (STATISTICAL STUDY OF THE ROLE OF TOBACCO, ALCOHOLIC BEVERAGES, AND POOR BUCCAL HYGIENE AS ETIOLOGICAL FACTORS C 12500 OF EPIThSLIOMAS OF THE UPPER AERO-DIGESTIVE Blundi, E. TRACT.) Ouest Medical 22(13-14-15-16-111 A BATALHA DO CANCER DO PULMAO. Cancer 1103-8, JUTTU-317710171969, French (Abs. do Pulamol eeu Terrivel Preco. (THE FIGHT ACONST CANCER. Cancer of the Detailed stat,:tics were presented Lung: It's Terrible Price.) Brasil regarding the type and importance of the Madico 83te. .:198-205, Jul-Aug ran smoking, drinking and dental hygiene Iranieee (Abe.) practices of the patients, who ranged in age from 36 to 84 years.Eighty-nine of Lung cancer mortality statistics the patients were manual workers.Ninety- have been presented indicating that the nine had smolced, with 93 etill active rise 1'. mortality in certain countries smokers; 90 percent were listed is app. caching epidemic proportions. drinkers) 88 had practiced po,r .ntal Offic:LA reports have demonstratti the hygiene. Tobacco, in agreemeat with rolatic-rship botween cigarette eu,Altz numerous statistical and experimental and iarg cancer. Smoking more th).) studios, was the most frequent factor. other factor, was held responsible for Alcohol while not a determining factor, epideraold and undifferentiated cercinoma might play a role as a favoring factor. of the lung. U. S. efforts in cigarette Poor dental hygiene no doubt played an labeling and the presence of c.itiamoking important role in the genesis of certain post(rs on Poet Office tru,:ks were cited

cancers.The statistics also showed that with the reminder V- , nothing comparable the level of °education' as evidenced by to this has been ....tempted in Brazil. the buccodental hygiene, on the whole, The author emphasized the need for prompt was rather mediocre. diagnosis of lung cancer, utilizing techniques ranging from the simplest procedures to exploratory thoractomy. In C 12459 the high risk (smoker) age groups, X-ray Samuel, K. C., Havant, H., and L-gani, K. B. and cytological examination of the sputum EPIDEMIOLOGY OF CAL CARCINOMA ,N EASTERN every .hree months was considered manda- DISTRICTS OF UTTAR PRADESH. Journal of tory. the Indian Medical 4secciatiorn(171

C 12502 Mennig, H. C 12460 DiaGNOSTISCHE UND THERAPEUTISCHE ASPEKTE Kieeen, D. M., Brown, R. I. F., and Kiesen, BEI DER LEUKOPLAKIE DER MUNDHOHLE. M. (DIAGNOSTIC AND THERAPEUTIC ASPECTS OF A FURTHER REPORT CV PERSONALITY AND LEUXOPLAKIA OF THE ORAL CAVITY.) PSYCHOSOCIAL FACTORS IN LUNG CANCER. Zeitschrift fur Arztliche Fortbildjg Annals of the New York Academy of b3(17;i966-47-rep 1, 19(1, -UTFIIKE1114.) reiTriFerISZT2i15:5=5; Oct 11,7969. Leukoplakia was viewed as a precancerous state of the mouth =coma C 12466 which may lead to a true carcinoma. Pobee, J. O. M. and Christian, E. C. The exogenous and endogenous causes THE SIZE OF THE PROBLEM. A Survey of of leukoplekia and tho diagnosis and Liver Disease in Xorle Bu Teaching therapy of the different types of Hospital. Ghana Medical Journal leukoplskia were discussed. A special 8(2)876-83,-M-11177-- form (leucoceratosis nicotinica palati) has been found in the mouth cavities of heavy smokers in the higher decades C 12473 of life. British Medical Journal. CARCINOGENICITY OF TOBACCO MOSAIC VIRUS. British Medical Journal t(5674):36, Oct C 12513

4, 95 . De Muyldsr, Ch. REVISION D'UNE SERIE ININTERROMIVE DE 40.000 DOSSIERS DS L'OFFICE MEDICO - LEGAL. C 12513 (continued) C 12521 (continued) REFLEXIONS SUR LES MALADIES DES VOLES and pulmonary complications and observa- RESPERATOIRES, IA BRONCHITE ET LE CANCER tions of 70 caaes of surgical inter- DU POUMON. 'REVIEW OF AN UNINTERRUPTED vention has enabled the authors to judge SERIES OF 40,(00 FILES OF THE MEDICO- when to practice exeresis or to utilize LEOAL OFFICE. CONSIDERATIONS ON THE cobalt therapy, polyethylene tubes on DISEASES OF THE RESPIRATORY TRACT, BRONCH- cytostatics. In spite of the reputed ITIS AND LUNG CANJER.)Bulletin de incrimination of tobacco and alcoholic l'Academie Ro ale de MedFFEFili-difila 1 ue consumption in the etiology of r(7)72Z3723 , l ar ,sophagzal cancers the authors attribute the presence of these factors merely to The question is the possible rela- coincidence. tionship between chronic bronchitis and lung cancer. The cause of cancer being unknown, there is no direct answer. Two C 12524 Pr ways of approach are used. First a Kotin, P. bibliographical study, which includes the CARCINOONESIS OF THE LUNO: ENVIRON- epidemiology of chronic bronchitis and MENTAL AND HOST FACTORS, In: Liebow, lung cancer, Re well as the morphological A. A. and Smith, D. E. (Editors). The basis for their diagnosis.Thies approach Lung. International Academy of Pathology leads to ',he statement that both diseases Monograph. Baltimore, Md., The Williams are closely linked to tobacco smoke and Wilkins Co., 1968, pp. 203-25. (mainly cigarettes) and that the microscopic anatomy of the 'smokers lung' offers another link. Secondly, a review of C 12533 40,000 consecutive files of the "Office Jones, F. A. Medicolegall, of which 10,121 cover respi- OESOPHAOUS, STOMACH, AND SMALL ratory cripples, and 76, lung cancers; in INTESTINE--MEDICAL. Medical Annual comparison to the bibliographical study 87:51-93, 1969. there is such a lack of information on exposure to smokes and particularly to tobalco smoke, that no conclusion can be C 12589 drawn. The calculation of a parameter World Health Organization. *percentage of invalidity/years of HISTOPATHOLOOY OF LUNG TUMORS. First duration' in the lung cancer group and Report of Expert Committee on Cancer. in a control group of chronic bronchitis Oslo, Nov 17-22, 1958. WHO/CANC/2, without cancer does not give any pasitive Dec 11, 1558, 14 pp. evluence on the tendency to develop a cancer. A prospective study is necessary. (Author Abstract) C 12591 Zacho,A.Nielsen, J., and Laraen, V. ON 4NE CONSUMPTION OF UNBURNED TOBACCO IN C 12521 PATIENTS WITH CANCER OF THE STOMACH. Andreu, L., and Andreu Morate, J. Ma. Acta Chirur Ica Scandinavica 134(3-4): EL CANCER DE ESOFA00. SU DIAONOSTICO DIFERENCIAL E INDICACIONES TERAPEUTICAS. (CANCER OF THE ESOPHAGUS. ITS DIFFEREN- TIAL DIAONOSIS AND THERAPEUTIC INDICA- C 12597 TIONS.)Reviata Esnola de las Tuca Barcelo, L. Enfermed e r cab gel LESIONES CANCEROSAS INIC1ALES DE LA 290.7'41-4a,tai- , Spanish (Abe.). MUCOSA ORAL. (INITIAL CANCEROUS LESIONS OF THE ORAL MUCOSA.Anales de Medicine Esophageal cancer is third in the 54(4):332-50, DIc 19687-STIWITH TIMM-- listing of all diseases of the esophagus in Spain, with a high percentage observed From an oncological viewpoint oral in males, and with preferential localiza- lesions can be divided into precancerous tion in the middle and lower third of the and cancerous lesions. Precancerous esophagus.The mega-esophagus has been states include chronic inflammation, e:meet for possible neoplastio trans- degeneration of benign tumors, physiologic formation. The clinical and radiological involution and regenerative hypertrophy. symptomatology has been described as well There are 3 fundamental premalignant as the auxiliary methods (Pharmac0- histiologic alterations, the third being dynamic., therapeutic tests with sounds of the only real premslignant ones (1) progressive caliber, exfoliative cytology, cellular hyperplasia, (2) keratosis, and esopinagoscopy, and cineradiology) for its (3) dyskeratosis.Trecancerous lesions differential diagnosis with seophagitis, are those nolsological entities that esophageal varices, peptic ulcers, etc. biologically and histologically are not Experience gained from the study of hepatic malignant but which frequently end in a

156 1(o C 12597 (continued) C 12600 (continued) neoplastic degeneration. There are: (1) Institute Portugues de Oncolo la de leucoplasia, (2) papilloma, (3) papillar Francisco Uentll 35(11):29, 3 , Dec 1968, hypertrophy of the tongue, (4) Plummer- orir-r1gueee-TrEM Vinson syndrome, (5) Bowen's disease, and (6) fibroma. The morphology of oral This editorial comment briefly re- cancerous lesions in these initial states views arguments concerning the relative depends largely on where they begin and guilt of cigarette smoking and air pollu- the pre-existence of precursor lesions of tion in the etiology of lung cancer. the neoformation. There are 3 fundamental Results regarding cigarette smoking are anatomoclinic forms which can be observed considered inconclusive since it was as initial morphologies: (1) initial pointed out that laboratory animals sub- exophytic forme, (2) initial infiltrative jected to a cigarette smoke environment forms, and (3) initial ulcerative forms. do not develop lung cancer whereas dogs Oral lesions fwe found in the following who do not smoke do develop lung cancer. descending order of frequency: lips, It was also observed that the incidence tongue, floor of mouth, mucous of cheeks, of lung cancer was higher in cities than mucous of gums, and palate, Carcinogenetic in rural areas and the difference was irritative factors in the oral cavity in- manifest in smokers and nonsmokers alike. cludes (1) tobacco, (2) alcohol, (3) Mortality due to lung cancer was three syphilis, 4) caries, pyorrhea and dental times as high in cities es in the country. decubitue, (5) 'spices, ingested irritants, Specialists were in accord however rege.rd- and (6) trauma.The biopsy, smear, tap ing the necessity to.* energetic efforts in ma abrasion are commonly used to collect combatting cigarette smoking. suspected tissue.Methods of treating leukoplasia and small lesions are described. C 12605 Sirtori, C. C 12598 BIOLOOIA Y CITOLOO/A DEL CANCER PULIONAR. Boletim do Institut° Portugues de (BIOLOGY AND CYTOLOGY OF PULMONARY Oncologia de Francisco Gentil. CANCER.) Acta OinecoloFia 20(1): FACTORES QUE FAVORECEM 0 APARECIMENTO 37-52, Jen-rfn, Spar:len (Abp.) DO CANCRO. (FACTORS FAVORINO THE DEVELOPMENT OF CANCER.)Boletim Various causes of pulmonary cancer do Institute Port ea de76517gla are described, including carcinogenic der A0=:tioirEl=Z(g-rol-9, Sep 1968, hydra arbone, particularly benzopyrene, /5AlAgmese present in cigarette smoke and smog, mustard gas, lack of benzopyrine Present-day statistic, show that hydroxylase, X-rays, chromium, asbestos, the incidence of certain cancers, notably nickel, pulmonary cicatrices, lack of lung cancer, is constantly increasing vitamin A, genetic factors, viruses and whereas the incidence of other cancers is the psyche. A detailed description is declining, even in the absence of specific given of how pulmonary cancer is formed. therapy. The geographic dietribution of Immunologic aspects of cancer are dis- gastric carcinomas may be explained on the cussed along with its biology and basis of dietary differences. Its inci- treatment, the latter including prop- dence in Japan and Iceland was discussed hylactic and surgical treatment and briefly. Leukemias may result from a treatment of metastasen.The cytologic chromosomal defect, particularly chromo- diagnosie of tumorJ1 cells, precanceroua some 21 and Wilm's tumor from congenital metastatic cells, and cells altered anomalies. The rising incidence of lung by antimitotice, by radiation, by a lack tumors in the United States was attributed of folic acid, and by virus or virocytes to the smoking, especially inhaling, of is described. Results of mass studies tobacco.Examples of the rising incidence of smokers are summarized. in Britlish laity and a drop in British doctors, Who now smoke lees, and the rise in Iceland were cited to illustrate the C 12645 influence of tobacco on lung cancer Medicine. mortality. The possible role of air EL TABACO, LA SALUD Y LOS CIENTIFICOS. pollution was also considered. (TOBACCO, MALTH AND THE SCIENTISTS.) Medicine 29(91224-6, )ay -Jun 1969, Spanish (Abe. C 12600 Boletim do Institut° Portugues de Oncologia Tt.le editorial criticises works which de Francisco Gentil. have linked tobacco to long cancer 0 CIOARRO E 0 CANCRO DO PULMAO. (CIOA- but which have not followed scientific RETTES AND LUNO CANCER.) Boletim do methods in concluding this relationship.

137 C 12645 (continued) C 12648 (continued) The pofnt is made that although there ie Authorities of public hygiene of all an apprxent association between smokIng industrialized countries to deal with and lung cancer, there are many smokera the interrelation of air pollution and who do not have lung cancer airs that what bronchial carcinoma. Epidemiological has been and continues to be Is lerestimat- investigation has ehonn that air ed is the familial antecedenta of carter. pollution is one of the factors con- For example, there are African populations tributing to the increase in cancer that don't smoke and have no .1.1ng cancer. mortality. The risk to health brought Is the lack of cancer due to the fact that about "1y carcinogenic hydrocarbons in they don't smoke or is it becLuee there the atmosphere cannot always be ex- are no familial antecedents of cancer in pressed in terms of their concentration. these populations? Some of the modifying factors are discussed. The influence of smoking on lung cancer morbidity le also dis- C 12647 cussed.The reduction in the 6101113iOn Boletim do Institute Povtugues de of polycyclic hydrocarbons ie partic- Oncologia de Francisco (lentil. ularly necessary for prophylaxis of ALTERACOES RRECANCEROSAS NO EPITELIO bronchial carcinoma. DA BEXIGA. (PRECANCERCUS CHANGES IN THE EPITHELIUM OF THE BLADDER) Boletim do Institute Port ues de Oncoloraint C 12649 YiTinniE5MIT1 L 2T :15-777f5-71.61r," Horn, K., Dorre, W. H., and Wettig, K. 75FUNEEFFe710577) DAS BRONCHIALKARZINOM AUS KOMMUNAL- AYOIENISCHER SICHT. (BRONCHIAL CARCINOMA This is a summary of a publlshed work ',ROM THE VIEWPOINT OF PUBLIC HYGIENE.) by R. 0. Skade and J. Swinney of the Zeitschrift fur die Oesamte H lone and University of New Castle cones:ming the 'bre GrenueB1it7T518):562- ,ug Mr, diagnosis and treatment of camer of iginTian tAte.) the bladder. The belief that cancer cf the bladder is an occupational risk of The presence of carcinogenic nydro- workers exposed to substances yuch aarbons in the atmosphere makes it as o-sminophenols, benaldine or necessary for the authorities of public betrnaphthylamine, is well documented. hygiene of all industrialized countries It has also been suggested that to deal with the interrelation of air spontaneous cancer of the bladier may pollution and bronchial carcinoma. be due to carcinogenic substances pro- Epidemiological investigation hes shown duced by metabolic processes. Three that air pollution is one of the factors metabolites of tryptophan excreted contributing to the increase in cancer the urine are carcinogen? of ttis mortality. The risk to health brought The value of cytological examiration by cbout by carcinogenic hydrocarbons in the the Papp technique has been verified, cimosphere cannot always be expressed but a negative test is considered of in terms of their concentration. Some little value in the exclusion cf ct the modifying factors ire oiscussed. a spontaneous or recurrent tumor. it The redaction in the emission of has been recommended that workers exposed golycyclic hydrocarbons is particularly to chemical carcinogens be examined every necessary for the prophylaxis of six months which can reveal malignant bronchial carcinoma. In the future a cells in the urine long before the develop- further energetic investigation into ment of a tumor. The authors have listed the source of carcinogenic factors in the seven anomalies of the mucosa or the environment is necessary, an important bladder based upon their observation of role being assigned to public hygiene. 100 cases of tumora. (Author Abstract)

C 12548 C 12658 Horn, K., Dorre, W. H., and Wett1i, K. Harilam, I. W. F. DAS BRONCHIALKARZINOM AUS KONDWAL- CARCINOMA OF NASOPHARYNX. British HYGIENISCHER SICHt. (BRONCHIAL ElPire: Cancer "am 1 for FrETWIT7h, CARCINOMA FROM THE VIEWPOINT OF Tn nu FiliFFE 4 ar 7Tra, igtr: PUBLIC HYGIENE.)Zeitechrift fur Erkrankungen der Atmungsorgane-1750(1-2)1 27-32, Jun 1954, demon (Abs.) C 12616 Skinner, M. E. G. and Parker, D. A. The harmful constituents of cir THE CANCER RESEARCH UNIT OF MPILO CENTRAL pollution were reviewed. The nivaence HOSPITAL, BULAWAYO, RHODESIA. Britich of carcinogenic hydrocarbons in the Erlare Cancer Cam 1 for ReseFFEN7 atmosphere makes it necessary fcr the nnar MITT ar IT320, 1965.

i54 C 12677 C 12729 Brae, O. and Walter, D. C. FullmerC. D. and Parrish, C. M. THE CANCER REGISM, JAMAICA.Results PULMONARY CYTOLOGY. A DIAONOSTIG METHOD, for the Period from January to FOR OCCULT CARCINOMA. iota Ceologica September, 1966.British Empire 13(11):645-61, Nov 19697-- Cancer Campaign forWrirE17-Arinual 11475176 46( Fart 2 521. -2, 1966. C 12730 Nishimura, R., Pipkin, G. B., Duke, G. A., C 12678 and Schlegel, J. U. Grieve, J. M. NONENUMATIC FORMATION OF CINNABARINIC CANCER REGISTRY OF THE C.S.I. HOSPITAL, ACID IN URINE OF PATIENTS WITH TUMORS NEYYOOR KANYAKUMARI DISTRICT, S. INDIA. OF THE URINARY BLADDER. Investigative Registration. British Em ire Cancer Urology 7(3):206-14, Nov 1969. Cam i for ReiTTFEE7 nnua I Report ar 7T324-5, 1966. C 12741 Case, R. A. M. C 12679 SOME ENVIRONMENTAL CARCINOOENS. Coy, P. Proceedings of the Ro1 Society of IRRADIATION AND CHEMOTHERAPY IN LUNG RedicLie 62(0)7TUSE=6:-Oct 1969. CANCER. British Em ire Cancer Campaign for ReseaRTTATinua _eport-a(Pirt 2): 3134711-637 C 12749 Quinn, H. J. Jr. A NEW TECHNIQUE FOR OLOTTIC RECON- C 12692 STRUCTION AFTER PARTIAL LARYNOECTOMY. Chomet, B. Laryngoscope 79(11):1980-2011, Nov 1969. SOME FEATURES OF THE ORAL CARCINOMA. Presidential Address. Promeedin a of the Institute of MedrElhe o C 12751 affinao-n17/7734r; Nov1969. Kaufman, J. J. CURRENT THERAPY FOR CARCINOMA CF THE BLADDER. Postgraduate Medicine 46(61: C 12706 *C-102, Dec-f9gv. Efroimson, V. P. rEHETAKA3110IGUPECDOmocmatoo6PA30IOMAim C 12762 mpoiArai31H KAiinim0m-E3A Y WEiumEICA. Coeburn, H. S. GENETIKA ZLOKACHESTVENNYKH NOVOCBRAZOVANIY LUNG CANCER IN A MINING DISTRICT IN I MEKHANILMY KANTSEROOENELA U CHELCVEKA. RHODESIA. South African Medicrl (GENETICS OF MALIGNANT TUMORS AND THE Journal 43(13)'1T3U77174-0n-257 1969- MECHANISM OP CARCINOOENESIS IN MAN.) Vestnik Akademii Meditsinekikh Nauk tSSft24(6-77357sr, 1969, Rbssian-751.) C 12765 Watson, W. L. (Editor). Review of the literature dealt LUNG CANCER: A STUDY OF FIVE THOUSAND with the following topics: Mendelian MEMORIAL HOSPITAL CASES.Saint Louie, inheritance of several rare for of Mo., The C. V. Mosby Company, 1968, cancer and other tumors; inherited 584 pp. diseases predisposing toward malignancy; forms of cancer with the role of family predisposition; study of cancer in one- C 12766 ovum-and two-ova twins as indication of Melamed, M. R. the range of inherited predisposition to PATHOLOGY. In: 'iateon, W. L., (Editor). cancer; en4 the mechanism of carcinogene- Lung Cancer: A Study of Five Thcusand aim. It was stated that lung cancer Memorial Hospital Catlett. Saint Louis, Mo., appeared more frequently in smokers than The C. V. Mosby Company, 1968, pp. 35-138. nonsmokers but conflicting data were also cited. It was concluded that a comprehension of the mechanism of the development of C '2767 malignant tumors 'n humans necessitated La Due, J. S. collecting data in tha probability of CLINICAL FEATURES. In: Watson, W. L., repeated morbidity in families, the rela- (Editor). Lung Cancers A Study of Five tive role of family factors, somatic Thousand Memorial Hospital Cases.Saint disturbances and hereditary predisposition. Louis, Mo., The C. V. Mosby Company, 1968, pp. 139-50.

:S9 /615 C 12768 C 12775 Sherman, R. S. and Phillips, S. J. Cliffton, E. E. and Luomahen, R. K. J. RADIOLOGIC DIAGN06- OF PULMONARY TYPES AND TECHNIQUES OF SURGERY MOST NLOPLASMS. In Watson, W. L., ;Editor). COMMONLY USED. Surgical Treatment. Lung Cancer: A Study of Five Thousand In: Watson, W. L., (Editor). Lung Memorial Hospital Cases. Saint Louis, Cancers A Study of Five Thousand Memorial Mo., The C. V. Mosby Company, 1968, Hospital Cases. Saint Louis, Mo., The pp. 151-97. C. V. Mosby Company, 1968, pp. 274-98.

C 12769 C 12776 Watson, W. L., Pool, J. L., and Lynch, S. Watson, :. L. BRONCHOSCOPY. In: Watson, W. L., TYPES AND TECHNIQUES 0? SURGERY MOST (Editor). Lung Cancer: A Study of Five COMMONLY USED. Extended Surgical Thousand Memorial Hospital Cases. Saint Procedures at Memorial Hospital. Louis, Mo., The C. V. Mosby Company, Ins Watson, W. L., (Editor). Lung 1968, pp. 198-204. Cancer: A Study of Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby CulmanY, 1968, C 12770 pp. ?99-307. Melamed, M. R. and Cahan, W. G. CYTOLOGY. In: Watson, W. L., (Editor). Lung Cancer: A Study of Five Thousand C 12777 Memorial Hospital Cases. Saint Louis, Phillips, R. F. and Hilaris, B. S. Mo., The C. V. Mosby Company, 1968, pp. RADIATION THERAPY. Ins Watson, W. L., 205-26. (Editor). Lung Cancers A Study of Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby 12771 Conr,any, 1968, pp. 308-22. Pool, J. L. and Conte, A. J. SURGICAL PROCEDURES FOR DIAGNOSIS. In: %.atson, W. L., (Editor). Lung C 12778 Cancer: A Study of Five Th:tsand Henschke, U. K., Hilaris, B. S., Mahan, Memorial Hospital Ca^et.. Saint Louis, G. D., and Wright, F. E. Mo., The C. V. Mosby Company, 1968, pp. INTERSTITIAL IMPLANTATION OF RADIO- 227-46. ACTIVE SEEIS DURIN3 THORACOTOMY. In: Watson, W. L., (Editor).Lung Cancer: A Study of Five Thousand C 12772 Memorial Hospital C:.ses. Saint Freiman, A. H. Louis, Mo., The C. V. Mosby Company, EVALUATION FOR TREATMENT.Medical 1968, pp. 323-46. Evaluation. In: Watson, W. L., (Editor). Lung Cancer: A Study of Five Thousand Memorial Hospital Cases. Saint Louis, C 12779 Mo., The C. V. Mosby Company, 1968, pp. Golbey, R. B. and Karnofsky, D. A. 247-57. TYPES AND TECHNIQUES OF CHEMOTHERAPY. Chemotherapy. In Watson, W. L., (Editor). Lung Cancers A Study Of C 12773 Five Thousand Memorial Hospital Cliffton, E. S. Cases. Saint Louis, Mo., The C. V. EVALUATION YOIR TREATMENT. Criteria Mosby Company, 1968, pp. 347-59. for Operability and Reaectability. In: Watson, W. L., (Editor). Lung Cancer: A Study of Five Thousand C 12780 Memorial Hospital Cases. Saint Louis, Cliffton, E. S. and Lawrence, W., Jr. Mc., The C. V. Mosby Company, 1968, pp. TYPES AND TECHNIQUES OF CREMOTHERAFi. 258-62. Regional Chemotherapy. Ins Watson, W. L., (Editor). Lung Cancers A Study of Five Thousand Memorial Hospital C 12774 Cases. Saint Louis, Mo., The C. V. Howland, W. S. nd Ryan, G. M. Mosby Company, 1968, PP. 360 -75. ANESTHESIOLOGY: PREOPERATIVE EVALUATION AND MANAGEMENT IN THE OPERATING .11-10 RECOVERY ROOMS. In Watson, W. L., C 12781 (Editor). Lung Cancer: A Study of Cliffton, E. E. and Luomanen, R. V. J. Five Thousand Memorial Hospital Cases. RELATIONSHIP CF PATHOLOGY TO DIAGNOSIS Saint Louis, Vo., The C. V. Mosby AND TREATMENT. Epidermoid Carcinoma. Company, 1968, pp. 263-73. In Watson,'. L., (Editor). Lung

160 144 12781 (continued) C 12787 (continued) Cancer: A Study of Five Thousand Lung Cancer: A Study of Five Thousand Memorial Hospital Cases. Saint Louis, Memorial Hospital Cases. Saint Louis, '1., The C. V. Mosby Company, 1968, Mo., The C. V. Mosby Company, 1968, pp. pp. 376-86. 446-65.

C 12782 C 12788 Watson, W. L. and Farpour, A. Gutowski, F. RELATIONSHIP OF PATHOLOGY TO DIAGNOSIS NURSING MANAGEMENT OF THE PATIENT WITH Terminal Bronchial or LUNG CANCER. Ins Watson, W. L., AND TREATMENT. A Study of Five Alveolar Cell Cancers A Study of (Editor). Lung Cancers Saint 265 Cases. In: Watson, W. L., Thousand Memorial Hospital Cases. (Editor). Lung Cancer: A Study of Louis, Mo., The C. V. Mosby Corpany, 19C8, Five Thousand Memorial Hospital Cases. pp. 466-79. Saint Louis, Mo.,, The C. V. Mosby Company, 1969, pp. 387-93. C 12789 Klingon, G. H. C 12783 NEUROLOGIC IMPLICATIONS. In: Watson, A Study Goodner, 1. T. W. L., (Editor). Lung Cancer: RELATIONSHIP OF PATHOLOGY TO DIAGNOSIS of Five Thousand Memorial Hospital Cases. AND TREATMENT. Bronchial Carcinoid Saint Louis, Mo., The C. V. Mosby Company, and Cylindroma. Ins Watson, W. L., 1968, pp. 480-7. (Editor). Lung Cancer: Study of Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby C 12790 Company, 1968, pp. 410-5. Myers, W. P. L. HORMONAL MANIFESTATIONS. In: Watson, W. L., (Editor). Lung Cancer: A Study C 12784 of Five Thousand Memorial Hospital Cases. Papaioannou, A. N. and Watson, W. L. Saint Louis, Mo., The C. V. Mosby Company, RELATIONSHIP OF PATHOLOGY TO DIAGNOSIS AND 1968, pp. 488-503. TREATMENT. Primary Lymphoma: A Clinical Appraisal. In: Watson, W. L., (Editor). Lung Cancer: A Study of Five Thousand C 12791 Memorial Hospital Cases. Saint Louis, Luomanen, R. K. J. and Watson, W. L. Mo., The C. V. Mosby Company, 1968, pp. AUTOPSY FINDINGS. Ins Watson, W. L., A Study of 416-27. (Editor). Lung Cancer: Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby C 12785 Company, 1968, pp. 504-10. Watson, W. L. and Anlyan, A. J. RELATIONSHIP OF PATHOLOW: TO DIAGNOSIS AND TREATMENT. Primary Leiomyosarcoma: C 12792 A Clinical Evaluation of Six Cases. In: Watson, W. L. Watson, W. L., (Editor). Lung Cancer: SURVIVAL AND SALVAGE RAZES: THE PATIENT'S A Study of Five Thousand Memorial Hospital CHANCE FOR RECOVERY.Five-year Survival. Lung Cancer: Cases. Saint Louts, Mo., The C. V. Mosby Ins Watson, W. L., (Editor). Company, 1968, pp. 428-41. A Study of Five Thousand Memorial Hospital Cases. Saint Louis, Mo., The C. V. Mosby Company, 1968, pp. 511-3. C 12786 Watson, W. L. RELATIONSHIP OF PATHOLOGY TO DIAGNOSIS C 12793 AND TREATMENT. Multiple Primary Cancers. Beattie, E. J., Jr. Lil Watson, W. L., Ins Watson, W. L., (Editor). Lung OUTLOOK FOR TREATMENT. A Study of Five Thousand Memorial (Editor). Lung Cancers A Study of Five Cancers Saint Hospital Cases. Saint Louis, Mo., The Thousand Memorial Hospital Canes. C. V. Mosby Company, 1968, pp. 442-5. Louis, Mo., The C. V. Mosby Company, 1968, pp. 529-34.

C 12787 Rasmussen, L. H. and Goodner, J. T. C 12800 MANAGEMENT OP THE PATIEM: WITH ADiANCED Baird, J. A. THE EARLY DIAGNOSIS OF CARCINOMA OF THE LUNG CANCER. Ins Watson, W. L., (Editor). LUNG: THE IMPORTANCE OF THE INCIDENTAL

161 165. C 12800 (continued) C 12807 (continued) CHEST RADIOGRAPH.New Zealand Medical of breast cancer, howe7er, is still Journal 70(34):34-67Tul 1969. outstanding. The manifold reasons reside in the lack of edification of the inhabitants, the complexity and the mis- C 12806 leading nature of the precancerous symp- OLejnicek, M. and Meluzin, J. toms, occasionally aggravated by non- OSUDY NEMOCNiCH S RAKOVINOU PLIC. target specific diagnosis which necessar- (THE FATE OF PATIENTS WITH LUNG ily leads to improper choice of therapy. CANCER.) Vnitrni Lekerstvi Breast self-examination should .0,1 jut: as 15(9):870471;17-007.17iFh (Abs.) much part of the basic education of yourg womanhood as the familiarity with the A series of 349 Patients treated Oeleterious effects of habit forming so- with a diagnosis of lung cancer was cial addictions such as the consumption submitted to analysis.Bronchoscopic of hard liquor, smoking or the adoption investigation was performed in 243 of dietetic excesses. Tha postoperative patients. Signs chaxecteriatic for care and documentation for the period of the presence of cancer were found in 1952-1957 reflects a survival index of 81 percent of cases with the central more thenFyears among 108 operated type of growth, and in 30 percent of patients e. 50.5 percent, whereas for cases with a peripheral tumor. His- 1958-1962 the survival index was in- tological or cytological verification creased to 67.5 percent for 108 operated of the diagnosis was obtained in 61 patients. Similar graphic presentetion Percent and 45 percent of cased r.opec- and breakdown is also given for colon and tively. A diagnosis of lung cancer for pulmonary cancers.The most disap- based entirely on clinical and pointing aspect of the study is concerned roentgenological evidence and not with the pancreal, irtestinal, and gall- supported, by either bronchosnopical, bladder nancsrs or stomach sarcomas! histological or cytological proof was these ronaally are not detected in their made in 95 patients.Resection was incipient formative stage by the stan- advised in 106 patient& suffering 'rom dard screening tests. lung cancer or from lesions highly suspicious of lung cancer. Operation was refused by 33 patients, in another C 12808 4 cases the surgeon did not agree to Kessler, P., Kollar, L., ?aster, T., operate. A total of 69 patients were and Buzna, E. su:mitted to operation. In 49 of those ADATOK A TUDORAK OPERAIHATOSAGAHOZ ES cancer was confirmed - 36 had a resec- A MUTETI EREUMENYEKNEZ. (DATA ON tion and 13 only a thoracotomy. No SUCCESSFUL SUROICAL FEA51BILITIES ON evidence of carcinoma was found at PULMONARY CANCER AND INTERPRETATION operation in the remaining 20 cases. In OF OPERATIVE RECORDS.) Orvosi Hetilso 12 instances a benign tumor was present, 110(3):115-21, Jan 19, 1969, HuTgiTriii once a lymPhogranvloma vas found and in (Abs.) 7 no nooplestic lesion could be established. Six out of 36 cases whose lung cancer Recorded incidence of pulmonary was removed by resection survived for 5 cancer during the pest 7 years was years. Out of the 30 non-surgical cases minutely elaborated. Among 540 only a single patient survived following clinical patients 323 underwent surgery, actinotherapy for oat-cell carcinoma. whereas 222 (41 p. cent) were subjected The need for early surgical therapy was to resection. The foctore spelling stressed. (Author Abstract) potential success in surgery are contingent upon early detection, target specific appraisal of the incipient C 12807 stage and tissue typing. Fourteen Kocsis, S. curative resectionsere performed against A RAXELLENES KUZDELEM NVANY 75 multifarious and %3 LEHEIOSEGEROL, VAS MEOYEI ADATOK ALAPJAN. resections. The preponderance of therapy (SOME FEASIBILITIES IN THE STRUGGLE consisted of 129 lobectomies against AGAINST CANCER, BASED ON CLINICAL CASES 81 surgical cases of pneumonectomy. FOR THE COMITAT VAS.) Orvosi Hetila2 Succensful surgical restoration on 23 110(36):2099-102, Sep 7, 1969, Triiiiirran subjects is describe!. The rate of (Abe.) Primary mortality, subsequent to surgery, was 12 percent with cardiorespiratory The most remarkeOe success in the insufficiency as the leading lethal cause. war on cancer was accomplished ir the Among the 82 patients resected prior to prevention of cervical cancer. Tle 1964, 45 percent, i.e. 37 subjects, hive anticipated success in the early detection survived over 3 years. According to

162 C aom (continued) C 12813 (continued) the survey, lobectany appears to he of no lesser surgical significance than Autopsy material over a period of pneumonectomy. Ile most promising 45 years including 25,104 autopsies done results were registered in curative on patients aged rover 19 years were The subjects of analysis were resections. The diminished chance of analyzed. survival in the case of metastasis, cages of primary hepatic carcinoma and still should justify this type of liver cirrhosis with particular reference surgery. In the confrontation with to coexistence of both these conditions. cancer, surgery is still the most effec- Primary carcinoma of the liver occurred tive remedy in terms of prolonging the frequently in a cirrhotic liver (37.14 life of the patient or as a palliative. percent). In over 5 percent of cases of liver Cirrhosis, presence of carcinoma should be expected. (Author Abstract) C 12810 Varga, G., Kovacs, B., and Kertes, 1. NEOY Mina/ MALIGNUS TUMOR EGYUTTES C 12820 EIGFORDULASA.TRACHEARESECTIo ES Sjolin, K.-E. DIREKT ANASTOMOSIS SZEREPE A STOFMISBRUG CO CIOARETTER. (DRUG ABUSE TRACHEADAOANATOK OYOGYITASABAN. (THE AND CIGARETTES.) Ugeskrift for Laeger COINCIDENTAL MANIFESTATION OF FOUR 151(18):189-90, May T, 1969, - Danish [Abs.) MALIGNANT TUMORS. THE ROLE OF TRACHEAL SECTION AND OF DIRECT ANASTOMOSIS IN THE Cigarette smoking, and the consider- THERAPY OF TRACHEAL TUMORS.) Orvosi ation of it as a type of drug abuse, are Hetilap 110(32):1863-6, Aug 10-,IggI, briefly discussed. It is mentione that gaiTazo. (Abs.) cigarette smoking will lead to lung cantor, and that other diseases such as coronary A rare clinical coincidence of sclerosis are more apt to occur among the incongruous malignant tumors, tetrafold Population that smokes tobacco. To a in nature, was atudied in a 70 year o'.d limited extent, social attitudes are at locksmith-machinist, a habitual smoker, fault and it is stated that sclool boys Though ma- start to smoke at an early age to smoking 15 cigarettes per day. If the malignancy was in its primary Prove their masculinity, for example. stage, i.e. detectable prior to the cigarette smoking were not acquired during surgery and the patient had no complaints school years, it might possibly not become Since the connec- or other discomforts, only the tracheal a habit in 10-- life. adenoma was diagnosed.The bronchial tion between ..cw cancer and tobacco carcinoma was detected during the smoking is so w'4. :,tablished, it is uhi.ber money should be surgery. The bronchogram was negative. considered that no The blood sputtna as well as the cytologic spent in research. .-itner these funds fir.dings without the recognition of the shoad be used to canc.!: the habit of tracheal adenoma would have had a smoking. different medical interpretation.The post mortem study has revealed that the squamovs bronchial carcinoma has Sealed C lkS23 the fate of the patient and omission of Sand, L. the latte:, surgery would have zench.red PROBLEMI DE PREVENZIONE DEI TUMORI. the tracheal operation meaningless.The Prevenzione della Malettla Neoplastica, patient was further encumbered with nodu- Significato, Possibilita e Limit'. lar hepatoceliular carcinoma incipient on (PROBLEM3 OF TUMOR PREVENTION.Prevention the portalis cirrhosis substrnte and still of Neoplaatic Disease, ita Significance, more with adenocarcinoma of the stomach. Possibilities and Limits.)Minerva The tracheal adenoma was relieved by Medics: 60(74)13460-8, Sep 15, 1969, tracheal resection. The suture on the Italian (Abs.) tracheal anaetomosis has healed effec- A general discussioa is presented on tively. The differential stages of the with malignancies are displayed by photo problems in the prevention of tumors, biopsies. major emphasis on the three essential types of prevention and on intervention programs for human r.gan sites where tumors moat The World Health C 12813 frequently develop. Starzyk, H., Sosnik, H., Oleszkiewicz, L., Organizationls delineation of ontological and Szydlowski, Z. Prevention as primary, secondary, and RAK PIERWOTNY I MARSKOSC WATROBY W tertiary is used as the basis for this MATERIALE SEKCYJNYM. (PRIMARY CARCINOMA discussion: Primary prevention concerns AND CIRRHOSIS OF THE LIVER IN AUTOPSY the study of exogenous and endogenous carcinogenic agents; secondary encompasses MATERIAL.) Polski Todnik Lekarski 24(46)31757-17ga I7, 1969,- 7oTfeE- (Abs.) the removal of certain localized or

161 C 12823 (continaed) C 12833 generalized pathological alterations that Land, F. often lead to the development of a ROLE OF THE GENERAL PRACTITIONER OF malignant tumor Prd are classified as MEDICINE IN ORAL CANCER. In: Oral "precancerous states"; tertiary preven- Cancer. Interprofessional Symposium, tion is essentially the diagnosis of a U.S. Department of Health, Education, neoplasia that exists but has not yet and Welfare, Public Health Service, manifested clinical signs. The organ Public Health Service Publication sites described with regard to prevention No. 1806, 1969, pp. 37-8. are the female genitalia, the respiratory apparatus, esophagus and stomach, colon and rectum, breasts, urinary apparatus, C 12834 and akin.The periodic control of sub- Wilk, C. jects particularly exposed to respiratory ROLE OF THE GENERAL PRACTITIONER OF neoplaslas--heavy smokers, chronic DENTISTRY IN ORAL CANCER. In: Oral bronchitics, and those in certain work Cancer. Interprofessional Symposium, categories--is advocated.With regard U.S. Department of Health, Education, to stomach and esophageal tumors, primary and Welfare, Public Health Service, prevention is reported to be very impor- Public Health Service Publication tant for cigarette smokers. No. 1806, 1969, pp. 39-42.

C 12829 C 12835 Ross, W. L. Moore, C. ACTIVITIES OF THE CANCER CONTROL EDUCATION AND ORAL CANCER. Ins Oral PROGRAM. Yn: Oral Cancer. Inter- Cancer. Interprofessional Symposium, professional Symposium, U.S. Department U.S. Department of Health, Education, of Health, Education, and Welfare, and Welfare, Public Health Service, Public Health Service, Public Health Public Health Service Publication No. Service Publication No. 1806, 1969, 1806, 1969, pp. 83-92. pp. 3-11.

C 12830 Clark, R. L. all also A 10201, A 10203, A 10228, A 10239, PRESENT STATUS OF CANCER RESEARCH. rrs245, A 10251, A 1a305, A 10332, In: Oral Cancer. Interprofessionil A 10334, A 10336, A 10352, A 10396, Symposium, U.S. Department of Health, A 10397, A 10399, A 10417, A 10428, Education, and Welfare, Public Health A 10441, A 10454, A 10455, A 10469, Service, Public Health Service Publica- A 10488, A 10521, A 10531, A 10534, tion No. 1806, 1969, pp. 12-6. A 10567, A 10572, A 10585, A 10831, A 10859, A 11291, A 11552, A 11595, A 11889, A 11891, A 11918, A 12529, C 12831 B 10316, B 10375, B 10406, B 10415, Wood, D. A. B 10465, B 10485, B 10496, B 10515, ROLE OF THE MEDICkL PATHOLOGIST IN B 1(1546, E 10613, B 10816, B 10821, ORAL CANCER. In: Oral Cancer. B lcd43, B 10844, B 10927, B 11145, Interprofessional Symposium, U.S. B 11147, B 11269, B 11307, B 11394, Department of Health, Education, and B 11515, B 11628, B 11901, B 12040, Welfare, Public Health Service, Public B 12398, D 11363, D 11879, D 12319, Health Fsivice Publication No. 1806, E 10574, E 11359. F 1065l, F 10972, 1969, lx). 27-30. I 11580, J 11323, 3 11753

C 12832 Shafer, W. G. ROLE 0? THE ORAL PATHOLOGIST IN ORAL CANCER. In: Oral Cancer. Inter- Professional Symposium, U.S. Department of Health, Education, and Welfare, Public Health Service, Public Health Service Publication No. 1806, 1969, pp. 51-6.

164

1 WV SECTION D. NONNEOPLASTIC RESPIRATORY DISEASES

D 10189 D 10200 (continued) Grandjean, E., Capitalne, Cl., and tion was found tetween ventilatory func- Gilgen, A. tion values and ;he number of years spent TOXIKOLOGISOHE WIRKUNGEN DURCH in a dusty (occupational) environment, INHALATION VON NO2 BEI DER MAUS. productive cough and shortness of breath. (TOXICOLOGICAL EFFECT OF INHALA- Persons with a history cf dust exposure TION OF NO2 IN MICE.) Zeitschrift suffered more frequently from the effects fur Praeventivvedizin 1n142-57, of weather conditions and also displayed 1968, German kAn77-- a higher incidence cf nasal catarrh. No valid opinion could be expressed concern- Thu influence of P. nitrogen ing correlations between housing condi- dioxide air mixture on the physical tions and cough or between housing and performance of mice wa- investigated lung function. There was a satisfactory in an exposure chamber by single and agreement between FCV percent VC and PEER repeated tests. The most important values. There was good correlation of results are summarized: (1) Swimming symptoms characteristic for chronic non- test time showed that rice expose.. to specific lung disease with a number of 40 ppm nitrogen diox1,1e exhibited a radiological signs considered character- lowering of performance. The decreased istic for these disorders. Dyspnea was performance was more marked in the most frequently and significemtly courses with load.Nice exposed to associated with abnormal size, abnormal nitrogen dioxide showed a greater shape and position respectively of the susceptibility to fatigue than control heart shadow, with reduced diaphragmatic mice. The decrease in physical mobility, barrel chest, widened performance was reversible and retrocardial space, decreased brcacho- appeared to return to control levels vascular marking and increased trans- 2 weeks after the last exposure. (2) lucency of the lung fields. Correlations The chronic toxicity tests extended were highly sigAlficant between some for a period of 10 weeks and radiological signs- adhesions, reduced alternated with 10 weeks of exposure diaphragmatic mobility, decreased to pure air, and in tests of acute bronchovascular markings, increased toxicity the single exposures translucency of lung fields and functional lasted 6 hours. The approximate LD50 values such as VC, FEV, and FEV, percent values in chronic tests were 120 ppm VC. The data indicate that chronic and in acute tests, 140 ppm. (3) The bronchitis is a common and serious disease tolerance tests showed that a in certain age groups in specific areas single exposure to 20 ppm nitrogen of Czechoslovakia. dioxide reduced the mortality from subsequent exposure to 200 ppm from 90 to 1.2 percent. (4) Histological D 10214 study of the lungs of 13 mice Doerken, H. sacrificed 4 weeks after the last THE ETIOLOGY OF MYOCARDIAL INFARCTION- - exposure of 8 weeks duration revealed WITH SPECIAL REFERENCE 70 CIGARETTE a thickening of the septa in 6 mice. SMOKING AMONG YOUNG CORONARY PATIENTS AND THOSE WITH SECOND HEART ATTACKS. In: Wynder, E. L. and Hoffmann, D. (Editors). D 10200 Toward A Less Harmful Cigarette. U. S. Jan,lk, E. Department of Health, Education, and ERLDBEZNE ZAVERY A PERSPEKTIVA Werare, Public Health Service, National EPIDEMIOLCOICKEHO VYZKUMU 0 CHRONICKE Cancer Institute Monograph Nc. 28, Jun BRONCHITIDE. (PRELIMINARY RESULTS AND 1968, pp. 21-5. FUTURE ASPECTS OF THE EPIDEMIOLOGICAL STUDY ON CHRONIC BRONCHITIS.)Rozhledy Tuberkulose a v NemoCech Flicnich D 10220 28(21:f32-41, 1968, Czech (Absa Auerbach, 0., Hammond, E. C., Kirman, D., Garfinkel, L., and Stort, A. P. A total of 8,538 chronic bronchitis THE EFFECT OF DIRECT CIGARETTE SMOKE patients in Chicago, Brno, London and INHALATION ON THE RESPIRATORY TREE rural areas of England as well as rural OF DOGS. In: Wynder, E. L. and and industrial areas of the Netherlands Hoffmann, D. (Editors). Toward were studied. Smoking appeared to have A Less Harmful Cigarette. U. S. an adverse effect on lung function values Department or Health, Education, and and cough, sputum production, and short- Welfare, Public Health Service, ness of breath. A significant correla- National Cancer Institute Monograph No. 28, Jun 1968, pp. 65-70.

165 D 10221 D 10326 (continued) Daihamn, T. these workers are inevitably exposed EFFECT OF DIFFERENT DOSES OF TOBACCO (particularly the exposure to cold) are SMOKE ON CILIAR7 ACTIVITY IN CAT. responsible. Attention is drawn to VARIATIONS IN AMOUNT OF TOBACCO SPIKE, chronic bronchitis as a social disease INTERVAL BETWEEN CIGARETTES, CONTENT and emphasis is laid on factors incident OF "TAR," NICOTINE, AND PHENOL. In: to the occupational environment (irritants Wynder, E. L. and Hoffmann, D. of the bronchial mucus, allergizing and (Editors). Toward A Less Harmful infectious agents) as the prime causes Cigarette. U. S. Department of of the disease.Smoking was also Health, Education, and Welfare, Public considered an important factor in the Health Service, National Cancer development of bronchitis. Institute Monograph No. 28, Jun 1968, pp. 79-67. D 10329 Kleinfeld, M., Messite, J., Shapiro, J., D 10247 Kooyman, 0., and Levin, E. El Batawi, F. A. and Hussein, M. A CLINICAL, ROENTGENOLOGICAL, AND HEALTH PROBLEMS OF INDUSTRIAL FHYSIOLOICAL STUDY OF MAGNETITE WORKERS IN EGYPT U.A.R. I. A WORKERS. Industrial Hygiene Review MEDICAL SURVEY OF TFE INDUSTRY 10(1)13-11, varma. IN ALEXANDRIA. Journal of the tiara Public kealth AssoaEtion 4 :2 3-36, 196&.. D 10330 caban, W. G. and Kirman, D. AN EFFECTIVE S1STEM AND PROCEDURE FOR D 10277 CIGARETTE SMOKING BY DOGS. Journal Heinrichs, E. H. and Hins, B. F. of Surgical Research 8(12)1567-75, EMPHYSEMA REHABILITATION PROGRAM IN Dic 1968. SOUTH DAKOTA. South Dakota Journal of Mediudne 21(11)757=5,-Narr9 ir---- D 10348 Webster, J. R. Jr., Kettel, L. J., Moran, D 10293 F., Bugaieski, S., and Cugell, D. W. Albert, R. E., Spiegelman, J. R., Shatsky, CHRONIC OBSTRUCTIVE PULMONARY DISEASE. S., and Lippman, M. A COMPARISON BETWEEN MEN AND WOMEN. THE EFFECT OF ACUTE EXPOSURE TO CIGA- American Review of Respiratory Disease T.STTE SMOKE ON BRONCHIAL CLEARANCE IN 98(6):102T=G-bec 1988. '.:1E MINIATURE DONKEY. Archives of gayironmental Health 18(1):36=41, Jan 1969. D 10381 Fletcher, C. M. RECENT CLINICAL AND EPIDEMIOLOGICAL D 10294 STUDIES OF CHRONIC BRONCHITIS. Sargent, T. S^lndinavian Journal of Respiratory_ SPONTANEOUS FNEUMOTHORAX.SurAo biieWer417265-W, 13W7. 36(1)129, 1968.

D 10416 D 10326 Petrilli, F. L. and Cavallaro, 0. De Pompeis, C. and Marcone, ). IMPORTANZA MED7C0 SOCIALE DELLE INDAGINE STATIS"ICA SULLk MORBILITA PNEUMOPATIE CRONICHE E DELLA LOBO BROCHITICA NELLE FORNAlI DI LATERIZI RIABIL1TAZIONE NELL' ANZIANO. E SUOI RIFLESSI IN MEDIC1NA SOCIALE. (SOCIAL MEDICAL IMPORTANCE OF CHRONIC (STATISTICAL INVESTIGATION OF BRONCHITIS PULMONARY DISEASES AND OF THEIR IN BRICK-KILN WORKERS AND ITS PLACE AS A REHABILITATION IN THE AGED.) Giornale SOCIAL DISEASE.) Medicina Sociale 18(7)1 di Geronotologia 16(5):407-21,-Vay 290-3, 1968, Italian CAW:T T968, Italian (Abs.)

A stun), of the incidence of chronic The authors review the problems bronchitis among 4,250 workers in 51 concerning chronic pulmonary diseases brick-kilns is reported.The frequency and relate about some researches of the disease was found to be above the carried out, outlining the difficulties general worker average and was especially of a statistical evaluation of data. high in workers who remove the bricks They also propose some technical from the kiln. It is suggested that the solutions for the rehabilitation of repeated changes of terperature to which chronic pulmonary diseases of old persons. (Author Abstract)

166 176 D 10444 D 10468(continued) Weis,, W. and the prompt and effective treat- CIGARETTE SMOKING AND DIFFUSE PULMO- ment of the recurrent bronchitic NARY FIBROSIS. American Review of el.isodes and all other measures Respiratory Disease 99(1)67-777, aiming at the elimination or attenua- Jer. 1969. tion of the environmental factors leading to a further impairment of pulmonary function (cigarette smoking, D 10448 atmospheric impurities and lack of Klelnfeld, M., Messite, J., Swencicki, an adequate grade of air humidity). R. E., and Shapiro, J. (Author Abstract) A CLINICAL AND PHYSIOLOGIC STUDY OF GRAIN HANDLERS. Industrial Hygiene Review 10(1):12-9;-JUR-17n. D 10470 Pochmon, 0., Skarabellova, M., and Legostov, J. D 10452 CHRONICKA OBSTRUKCNI BRONCHITIDA U Holma, B. HAVIRU V KARVINSKEM OKRESE. (CHRONIC THE ACUTE EFFECT OF CIGARETTE SMOKE OBSTRUCTIVE BRONCHITIS IN MINERS OF ON THE INITIAL COURSE OF LUNG KRAVINA DISTRICT.) Pracovni Lekarstvi CLEARANCE IN RABBITS. Archives of 20(8):366-71, Sep 1968, Czech (Abs.) Environmental Health 18(2):171-3, Feb One hundred and twelve miners suffering from obstructive bronchitis were, for certain Year., followed-up D 10456 by the department of occupational Berard, M. J. diseases of the Karvina distric'. INFLUENCE DES FACTEURS EXTRINSEQUES The highest rate of findings belong DANS LA BRONCHITE CHRONIQUE. to the age-group of 41-50 years (INFLUENCE OF EXTERNAL FACTORS IN (43 percent) working in average CHRONIC BRONCHITIS.) Journal de exposure of workplaces with high dust Medeci.ne de Lyon, 49 114911=7=L concentrations (breaking ground and 1331-071535-6, Sep 20, 1968, French faces) for 19 years. Pneumoconiosis (Abs.) in compensable stage was found in 20 percent of the miners. In clinical The sudden aggression on the analysis of 66 cases only 28 percent superior respiratory tract by gases or of miners reported typical asthmatic toxic fumes can produce definitive paroxysms. In 67 percent were found bronchial lesions.Such was the case, symptoms of lung-emphysema, often very for instance, during World War I, wi,,r1 progressed; in a half of this number the war gas; it can also occur during emphysema developed within 10 years work, in factorios or mines. The from the beginning c' the symptoms. By chronic irritation of the mucous otorhinolaryngological findings in membrales is less ascertained, but mo-t of the cases pathological changes it remains probable. It certainly cf the upper respiratory ways wet.. constitutes an aggravating factor, nd, the effect of a chronic inflam- perhap3 a causing but not a determining .,.tion of the nasal sinuses being one, inevitably. After all, chronic found as secondary.Chronic obstructive bronchfAis is perhaps merely constitu- bronchitis accompanying pneumoconiosis tional or diathetic. (Author Abstract! represents a relevant comp)icatiun of the primary disease. All miners in which the diagnoses of chronic obstruc- D 10468 tive bronchitis was determined, should Bonaccoreo, O. and Scillieri, F be replaced - within the mine - to work- L'INSUPFICIENZA RESFDRATORIA places with lower dust concentration. NELL'AI,ZIANO: ASPETTI PREVENTIVI E In cases of aggravation of respiratory CURATIVI. (RESFIRAT( : INSUFFICIENCY functions it is rocessary to place these IN TEE AGED: PREVENfiVE AND CURATIVE miners outside of the mine. (Author ASPECTS.) Giorn.le di Gerontclogia Abstract) 16(5):441-57747-rga7 Italfin (Abs.)

The t:eatment of chronic respir- D 10475 atory ,iseases is strictly connected Brun, J., Moulinier, J., Tuaillon, J., with '.1-e problem of the secondary Kcfman, J., and Blot, N. prevention of respiratory failure. POUMCN DETRUIT AU COURS D'UNE The most important aspects of such FOLYARhERITE MONIQUE PROGRESSIVE prevention are the early diagnosis CARACTERE FAMILIAL AVEC POWOIR

167

171 D 10475 (continued) D 10512 ANTIELASTASIQ.UE ELEVE ET 'POUVOIR Prineas, R. J., Tibblin, G., and ANTITRYPSIQUE ABAISSE. (LUNG DESTROYED Rose, G. IN THE COURSE OF A PROGRESSIVE CHRONIC ELECTROCARDIOGRAPHIC PATTERNS OF POLYARTHRITIS OF FAMILIAL CHARACTER RESPIRATORY DISEASE IN A WORKING WITH ELEVATED ANTIELASTIC AND LOWERED POPULATION. British Heart Journal ANTITRYPTIC POWER.) Lyon Medical 30(6):859-63, Nov 1968. 220(35):327-45, Sep 1968, PFgr1h(Abs.)

A 61-year old man, suffering fmom D 10513 a rheumatoid polyarthritis for many West Virginia. Medical Journal. years, and whose sister also suffered SMOKING AFFECTS WHOLE FAMILY. West from the same disease, has been Virginia Medical Journal 65(1):M7 observed. On the pulmonary level, in San 196g. addition to a fibrosis of the basal region, there was an extremely serious pulmonary destruction with a very D 10520 large bullous cavity occupying almost Kolbye, A. C., Jr. the entire left superior lobe.The CIGARETTE SMOKING AND PULMONARY antitrypsin power of the serum, EMPHYSEMA. Presented at the 5th reduced to 0.680 mg/m1, is significative Annual Meeting on Health Hazard of the heterozygous state of a genetic Appraisal, Indianapolis, Ind., Dec defect. The authors asserted net 10, 1968, 5 pP. alcoholic intoxication and nicotinism very certainly favored the deLradation of the elastic structure of the lung, D 10535 especially when the two toxic factors Maryland State Medical Journal. were associated as was the case in the CHRONIC BRONCHITIS AND EMPHYSEMA. patient (2 packs of cigarettes and 2 Maryland State Medical Journal liters of wine per day). 17(11):10/7GNov 1968.

D 104 82 D 10551 Robins, A. B., Epstein, H. H., Diamond, Tysinger, D. S., Jr., Walton, R. A., P. H., Plishner, M. J., and Finkelstein, and Adams, C. N. H. TREATMENT PHASE OF THE ALABAMA A PROJECT FOR THE FREVEATION OF CHRONIC RESPIRATORY DISEASE PROGRAM. DISABILITY FROM CHRONIC RESPIRATORY Southern Medical Journal 62(1):23-9, DISEASR IN WORKING MALES. American Journal of Public Health and the Na tion sRe=1-59(1):77-65, Jan 1969. D 10554 Wundohl, F. F. and Fackler, W. A. D 10505 THE LIFE CYCLE OF OLIN ANSINK. Blair, W. H., Henry, M C., and National Tuberculosis and Respiratory Ehrlich, R. DrieWgAssociation BuIntin 54(10): CHRONIC TOXICITY OF NITROGEN DIOXIDE. 3-6, Nov 1968. 2. Effect on Histopathology of Lung Tissue. Archives of Environmental Health 18(2):1-6g=97, Feb 1969. D 10555 Chadwick, D. R. CHRONIC RESPIRATORY DISEASES -- A D 10506 TIME FOR ACTION. (Editorial) Review Ehrlich, R. and denry, M. C. of Allergy 2212):1108-9, Dec 1T6767.-- CHRONIC TOXICITY OF NITROGEN DIOXIDE. 1. Effect on Resistance to Bacterial Pneumonia. Archives of Environmental D 10559 calth 17(6):860-5, Dec 1968. Anderson, T. W. and 3hephard, R. J. NORMAL VALUES FOR SINGLE-BREATH DIFFUSING CAPACITY - THE INFLUFNCE D 10510 OF AGE, BODY SIZE AND SMOKING HABITS. Mitchell, R. S. Respiration 26(1):1-7, 1969. OVILOCK IN EMPHYSEMA AND CHRONIC BRONCHITIS. New England Journal of Medicine 260(8)1445-6, Fob 20, 1969. D 10563 D 10594 Turner, W- A. Brinkman, O. L. and Block, D. L. CHRONIC OBSTRUCTIVE LUNG DISEASE. LONGITUDINAL STUDIES OF CHRONIC Nova Scotia Medical Bulletin 45(1)s OBSTRUCTIVE BRONCHIAL DISEASES. Int 3=1T, Feb 191T7---- deTreville, W. M. (Director). Emphysema in Industry. Medical Series Bulletin No. 10, Industrial Hygiene D 10566 Foundation of America, Inc., Pittsburgh, Boin, J. K. Pa., Jul 1966, pp. 72-89. EXPERT MD OPINIONS VARY ON MAJOR HEALTH HAZARD FACIN3 COAL MINERS. U. S. Medicine 5(1):4, 18, Jan 1, D 10595 1959. Gross, P. PATHOLOGICAL ANATOMY OF EMPHYSEMA ASSOCIATED WITH KNOWN OCCUPATIONAL D 10589 DISEASES. Ins deTreville, W. M. deTreville, R. T. P. (Director) (Director). Emphysema in Industry. EMPHYSEMA IN INDUSTRY.Medical Series Medical Series Bulletin No. 10, Bulletin No. 10, Industrial Hygiene Industrial Hygiene Foundation of Foundation of America, Inc., Pittsburgh, America, Inc., Pittsburgh, Pa., Jul Pa., Jul 1966, 127 pp. 1966, pp. 90-8.

D 10590 D 10596 Thurlbeck, W. M. Bates, D. V., Brinkman, 0. L., THE ANATOMY AND HISTOLOGY 0? CHRONIC Gocke, T. M., andStone, R. W. BRONCHITIS AND ALL FORMS OF EMPHYSEMA. IS EITHER CHRONIC BRONCHITIS OR Ins deTreville, W. M. (Director). EMPHYSEMA CAUSALLY RELATED TO OCCUPA- Emphysema in Industry.Medical Series TION? Ins deTreville, W. M. Bulletin No. 10, Industrial Hygiene (Director). Emphysema in Industry. Foundation of America. Inc., Pittsburgh, Medical Series Bulletin No. 10, Pa., Jul 2966, pp. 1-20. Industrial Hygiene Foundation of America, Inc., Pittsburgh, Pa., Jul 1966, pp. 99-108. D 10591 Wright, 0. W. CLINICAL ASPECTS OF EMPHYSEMA AND D 10597 CHRONIC OBSTRUCTIVE BRONCHIAL Hill, J. L., Fritz, J. W., Rady, R. B., DISEASE. Ins deTreville, W. M. and Standish, W. L. (Director). Emphysema in Industry. PRACTICAL MEDICOLEGAL PROBLEMS. Ins Medical Series Bulletin No. 10, deTreville, W. M. (Director). Industrial Hygiene Foundation of Emphysema in Industry. Medical Series America, Inc., Pittsburgh, Pa., Jul Bulletin No. 10, Industrial Hygiene 1966, pp. 21-43. Foundation of America, Inc., Pittsburgh, Pa., Jul 1966, pp. 109-24.

D 10592 Higgins, I. T. T. D 10598 BRONCHITIS AND RESPIRATORY DISABILITY Iamb, D. and Reid, L. IN POPULATIONS IN BRITAIN. Ins GOBLET CELL INCREASE IN RAT BRONCHIAL deTreville, W. M. (Director). Emphysema EPITHELIUM AFTER EXPOSURE TO in Industry. Medical Series Bulletin CIGARETTE AND CIGAR TOBACCO SMOKE. No. 10, Industrial Hygiene Foundation of British Medical Journal 1(5635): America, Inc., Pittsburgh, Pa., Jul 33-5, YiE-4, 1455. 1966, pp. 44 -55.

D 10607 D 10593 Gross, P. Gocke, T. M. .LE MECANISME DU TRANSPORT ALVEOLAIRE. FACTORS WHICH AGGRAVATE CHRONIC (THE ALVEOLAR TRANSPORT MECHANISM.) BRONCHITIS. Ins deTreville, W. M. ?Duman et le Coeur 23(10)0215-27, (Director).Emphysema in Industry. ITS7,FFiriCE TA777) Medical Series Bulletin No. 10, Indust...lel Hygiene Foundation of An outline of the two concepts of America, Inc., Pittsburgh, Pa., Jul alveolar clearance is briefly sketched. 1966, pp. 57-71. These concepts era: transport by ameboid motion of phagocytes and

i69 173 D 10607 (continued) D 10637 (continued) transport by the moving alveolar change: due to quartz dust. (3) For surface film of fluid. Among the obstructive bronchitis, the measurements factors possibly involved in the show that miners were not sick more mechanism of alveolar clearance the often than the general male population. following are discussed: the pulmonary (4) Only silicosis cases with large surfactant, atelectasis, intraalveolar formation of callosities and shrinking compaction of inhaled dust particles processes (B and C) show with an and the subsequent fragmentation of the incidence-rate of 63.4 percent beyond compacted dust masses, and peribronchio- the age of 55 years and incidence of lar adenomatosis. (Author Abstract) chronic obstructive bronchitis of about the twofold as would be expected in the light of the survey of the general male D 10615 population. (5) Contrary to mine dusts, Gandevia, B. smoking habits show an influence on the A PRODUCTIVE COUGH UPON REQUEST AS incidence of obstructive bronchitis. AN INDEX OF CHRONIC BRONCHITIS: While of 65 non-smoking men only 20 per- THE EFFECTS OF AGE, SEX, SMOKING cent show an increased flow resistance, HABIT AND ENVIRONMENT UPON PREVALENCE 100 heavy smokers with a daily IN AUSTRALIAN GENERAL PRACTICE. cigarette consumption of more than 20 Medical Journal of Australia 1(1): cigarettes show in 30 percent of the 16-20, air-747TM. cases an obstructive bronchial affection. The bronchial flow resistance lay in heavy smokers clearly above the value of D 10635 nonsmokers. The arterial oxygen- Indian Medical Record. pressure showed a reduction while the CLINICAL MANAGEMENT OF ASTHMATIC BRON- intrathoracal gas volume in heavy smokers CHITIS. Indian Medical Record 88(10): as compared to the non-smoking control 163-8, Oct 1968. group was elevated. (6) At the same dust exposure, miners who were heavy smokers became sick with chronic brc, D 10637 chitis, associated with increased bron- Ulmer, W. T., Reichel, O., and Werner, U. chial resistance, nearly twice as often DIE CHRONISCH OBSTRUKTIVE BRONCHITIS as miners with light tobacco consumption. DES BERGMANNES. UNTERSUCHUNOEN ZUR HAUFIOKEIT BEI DER NORMALBEVOLKERUNO UND BEI BEROLEUTEN. DIE BEDEUTUNO DEB D 10641 STAUBBELASTUNO UND DER EINFLUSS DES Kandus, J. and Rosmanith, 3. RAUCHENS. (CHRONIC OBSTRUCTIVE BRONCHITIS SCHADIGUNO DER ATENWEGE DURCH OF THE COAL MINER. AN EPIDEMIOLOGIC STUDY THOMASSCHLACKENVEHL. (DAMAGE TO i.3 OF ITS INCIDENCE IN THE NORMAL RESPIRATORY TRACT CAUSED BY GROUNE. POPULATION AND IN COAL MINERS. THE BASIC SLAG.) Internationales IMPORTANCE OF DUST AND SMOKING.) fur Oewerbepathologie and OeweiFY;lens Internationales Archly fur 2W1):5174,-1968, German (Abs.) Oewerbepathologi-e-WOewerbehyglene 25(1):75-98, 968, German (Abs.) The employees of the Thomas Fi.-cate Slag Mi/1 were examined according to the In the present investigation 952 BMRC Clinical-Epidemiological method. A steelworkers, 626 coal miners without considerable function of an injurios radiological signs of silicosis, 376 ingredient has been detected in the miners affected with silicosis of the airways.The authors have ascertainei a grades m n p A, and 304 miners suffering significantly higher incidence of c,-t11- from silicosis of the radiological cated chronic bronchitis (i.e. chronic grades B C have been examined. The recurrent mucopurulent bronchitis Fria findings were as follows: (1) Coal chronic obstructive bronchitis accorciing miners without silicosis showed, a to BMRC) in the employees of the Thcmas reduction of the arterial oxygen-Pressure Phosphate Slag Mill (15.15 percent), as of 3--4 mm Hg due to a stronger against the control group (1.79 percent) inhomogenity of the ventilation- and also the other group of perfusion-diffusion ratio. (2) (6.58 percent). The authors have sug- Reduction of the lung function values gested that in plur!.causal aetiology o' is not bound to the presence of the origin and development of chronic silicogenous dust deposits. The group bronchitis in these cases, conttit.1- miners with silicosis of the grades m n tion of the working conditions is a and A shows in its functional behavior dominant factor. Similarly, they hay,- no differences as compared to miners shown higher incidence of bronchc- without radiological evidence of lung pnewonia in these subjects. Mc, D 10641 (continued) D 20585 (continued) authors, however, could not succeed in was significantly higher in Osaka proving either the fibrogenous effect of district (6.5 percent) than in Tsuge Thomas slag or that the symptoms of region (0 percent). Pulmonary general organism impairment were a result hypofunction cases in Osaka district of the main bronchotropic injurious increased significantly in 40-55 year ingredient contained in that slag. old group. (Author Abstract) (Author Abstract)

D 10690 D 10685 Ayres, S. M. Takenouchi, S. THE EFFECTS OF AIR POLLUTION ON HEALTH. BOJ] GYOSHO GYOSHA NI OKERU MANSEI Delaware Medical Journal 42(1)19-14, KOKYUKI SHOGAI NI KANSURU TETIng. EKIOAKMTEKI KENKYU. (EPIDEMIOLOGICAL STUDIES ON CHRONIC RESPIRATORY DISTURBANCES AMONG EMPLOYEES IN A D 10695 CERTAIN ORGANIZATION'S WORKSHOP.) D'Anelli, A., Proscia, N., Sorisio, Nara rtku Zasshi 19(5-61:749-63, F., and Caratti, C. A. Trar1 68, Japanese (Abs. L'ENFISEMA POLMONARE CRONICO OSTRUTTIVO NEL MALATO ULCEROSO. (CHRONIC An attempt was made to investigate OBSTRUCTIVE EMPHYSEMA IN THE ULCER chronic respiratory disturbances among PATIENT.) Archivio per le Scienze 4,911 employees in a certain organiza- Mediche 125(61:191-4-,-May 1968, tion's workstop in Osaka district, but Italian (Abs. in particular 1,486 cases excluding pulmonary tuberculosis and other diseases After an examination of the of }clown causes were examined under literature data, a series of 54 cases consideration of abnormalities on of chronic obstructive emphysema X-ray findings, respiratory symptoms observed in 220 operated ulcer and pulmonary function in age groups, patients (25.9 percent) is presented. residential places, smoking habits It is considered that this value (especially, duration of smoking) and (and those reported by other w.:::kers) working places.A comparative study cannot be dismissed as matters of pure was mad: between Osaka district and chance. Turning on the possible Tsuge region (288 cases).The causes of such an association, statistical results obtained were as follows: (1). evidence is advanced in support of The incidence of abnormalities on X-ray the view that smoking, vagal hyper- findings in 1,486 cases in Osaka tonia, respiratory acidosis and district was 2.8 percent and increased hypoxia must be considered as as age advanced. Some significant providing the most direct pathogenetic difference of incidence of abnormalities link between the two morbid forms in on X-ray findings was observed on the same subject. (Author Abstract) 40-55 year old group betiweea Osaka district end Tsug., region, indicating that air pollution had effects on D 10705 incidence of abnormalities on X-ray Negreiros, B. and de Almeida, A. H. E. finiings even among the young aged ASMA E ENFISEMA. (ASTHMA AND group. (2). The incidence of abnor- EMPHYSEMA.) Rovista lrasileira malities on X-ray findings in Osaka de Medicina M7ITT57-61, Jul f968, district increased with prolonged Portuguese (Abs. duration of smoking (Smokers 3.1 percent, Nonsmokers 1.5 percent). But, there The authors begin their report was no difference between smokers and with the up to date concepts of nonsmokers in Tsuge region. (3). emphysema and asthma and their relation- Prevalence of respiratory symptoms ship. The two following questions are (production of sputum having presistent of practical interests (1) Is the or recurrent cough for one month or mechanism of asthma capable by more) showed some significant itself to develop the emphysema? difference between Osaka district (2) How much of emphysema has a and Tsuge region. (4). The prevalence chronic asthma? After a brief was significantly higher among smokers historical revision and commenting than among nonsmokers Sn Osaka district. the aspect an anatomo-physlopathcicgic Eut, there was no difference in Tsuge of both diseases, they concluded: region. (5). Pulmonary function test by (1) "Many asthmatics of today are Vitalor was performed in all cases in emphysematous but few emphysematous of both areas. Pulmonary hypofunction today were asthmatics". (2) The

171 /75- D 10705 (continued) D 10719 (continued) mechanism of asthma could make a HUMAN BRONCHI, In Proceedings of the emphysema if it could maintain the Eleventh Aspen Emphysema Conference, lung inflated after the end of the Aspen, Colorado, Jun 12-15, 1968, Current bronAhlal sp -n.This could only Research in Chronic Respiratory Disease, happen when b chial irritating factors U.S. Department of Health, Education, and became part of e process (chronic Welfare, Public Health Service, bronchitis, smoking and air pollution.) Washington, D.C., Public Health Service (3) "We believe that the physician of Publication, No. 1879, 19'69, pp. 191-7. an asthmatic patient has a great responsibility in the Presumption of a Emphysema, suggested by the pulmonary D 10720 function tests. the diagnosis of Davis, A. L. and McClement, J. H. emphysema only is certain under THE COURSE AND PROGNOSIS OF CHRONIC necropsis). Tie allergist should not go OBSTRUCTIVE PULMONARY DISEASE. In: Fru- far beyond his field, limiting himself ceedings of the Eleventh Aspen Emphysema to treating asthma and asking the help of Conference, Aspen, Colorado, Jun 12-15, a pneumologist if emphysema is envolved. 1968, Current Research in Chronic Respi- (Author Abstract) ratory Disease, U.S. Department of Health, Education, and Welfare, Public Health Service, Washington, D.C., Public D 10716 Health Service Publicatior, No. 1879, Anderson, W. H. and Williams, J. B. 1969, pp. 219-34. EFFECTS OF CIGARETTE SMOKE ON DISTRIBU- TION OF PULMONARY PERFUSION. In: Pro- ceedings of the Eleventh Aspen Emphysema D 10721 Conference, Aspen, Colorado, Jun 12-15, Gregg, I. 1968, Current Research in Chronic Respi- A STUDY OF THE CAUSES OF PROGRESSIVE AIR- ratory 'Disease, U.S. Department of WAYS OBSTRUCTION IN CHRONIC BRONCHITIS. Health, Education, and Welfare. Public In Proceedings of the Eleventh Aspen Health Service, Washington, D.0, Public Emphysema Conference, Aspen, Colorado, Health Service Publication, Nom. 1879, Jun 12-15, 1968, Current Research in 1969, pp. 75-9. Chronic Respiratory Disease, U.S. Depart- ment of Health, Education, and Welfare, Public Health Service, Washington, D.C., D 10717 Public Health Service Public,,cioa, No. Ballenger, J. J., McFarland, C. R., 1879, 1969, pp. 235-48. Harding, H. B., and Koll, M. THE EFFECTS OF AIR POLLUTANTS ON MUCOCILIARY CLEARANCE. Ins Proceedings D 10722 of the Eleventh Aspen Emphysema r:onference, Fletcher, C. M., Tinker, C. M., Hill, Aspen, Colorado, Jun 12-15, 1968, Current I. D., and Speizer, F. E. Research in Chronic Respiratory Disease, A FIVE-YEAR PROSPECTIVE FIELD STUDY OF U.S. Department of Health, Education, and EARLY OBSTRUCTIVE AIRWAY DISEASE. In: Welfare, Public Health Service, Proceedings of the Eleventh Aspen Washington, D.C., Public Health Service Emphysema Conference, Aspen, Colorado, Publication, No. 187' 1969, pp. 91-102. Jun 12-15, 1968, Current Research in Chronic Respiratory Disease, U.S. Depart- ment of Health, Education, and Welfare, D 10718 Public Health Service, Washington, D.C., Spain, D. M. Public Health Service Publication, No. THE DISTRIBUTION OF TRACHEOX.ONCHI, 1879, 1969, pp, 249-52. METAPLASIA (REGENERATIVE HYPERPLASIA) (ACE, SEX, CIGARETTE SMOKING AND RELA- TION TO REID INDEX{) -- PRELIMINARY REPORT. D 10723 In: Proceedings of the Eleventh Aspen Burrows, B. Emphysema Conference, Aspen, Colorado, THE COURSE CF PATIENTS WITH CHRONIC Jun 12-15, 1968, Current Research in CBSTRUCTIVE LUNG DISEASE. In Proceed- Chronic Respiratory Disease, U,S. Depart- ings of the Eleventh Asper. Emphysema Con- ment of Health, Education, and Welfare, ference, Aspen, Colorado, Jun 12-15, 1968, Public Health Service, Washington, D.C., Current Research in Chronic Respiratory Public Health Service Publication, No. Disease, U,S. Department of Health, Educa- 1879, 1969, pp. 183-6. tion, and Welfare, Public Health Service, Washington, D.r., Public Health Service Publication, No. 1879, 1969, pp. 253-8. D 10719 Anderson, A. E., Jr., Furlaneto, J, A., and :raker, A. G. SELECTIVE VENTING OF CIGARETTE SMOKE IN DICHOTOMOUS DUCTS AND TRESERVED D 10724 D 10734 (Continued) Holland, W. W., Halil, T., and Elliott, A. patients were treated for 4 months with THE EFFECT OF ENVIRONMENTAL FACTORS ON daily doses of 500 mg of Oxytetracyclin VENTILATORY FUNCTION 7N SCHOOL -CHILI N. and 8 mz of Bisolvon in the form of the Ir: Proceedings of the Eleventh Aspen combination drug Bisolvomycin. Bouts of Emphysema Conference, Aspen, Colorado, bronchiti6 could be prevented by means of Jun 12-15, 1968, Current Research in this treatment, and thus the advance of Chronic Respiratory Disease, U.S. Depart- the disease be limited. During the win- ment of Health, Education, and Welfare, ter of 1967/68, the acute exacerbation of Public Health Service, Washington, D.C., chronic bronchitis of 21 hospitalized Public Health Service Publication, No. patients was treated daily with 3x2 cap- 1879, 1969, pp, 259-72. sules of Bisolvomycin until improvement and afterwards with 4x1 capsule, of the combination drug until recovery. Side D 10725 effects and symptoms of intolerance Rylander, R. could not be observed with both types of ENVIRONMENTAL AIR POLLUTANTS AND LUNG treatment. (Author Abstract) DEFENSE TO AIRBORNE BACTERIA. In: Pro- ceedings of the Eleventh Aspen Emphysema Conference, Aspen, Colorado, Jun 12-15, D 10735 1968, Current Research in Chronic Respi- Gerwel, T. ratory Disease, U.S. Department of STAN GORNYCH DROG ODDECHOWYCH U Health Education, and Welfare, Public PRACOWNIKOW PRZENYSLU TYTONIOWEGO. (THE Health Service, Washington, D.C., Public STATE OF UPPER RESPIRATORY WAYS AMONG Health Service Publication, No. 1879, TOBACCO INDUSTRY WORKERS.) Mid c a

1969, pp. 297-304. Pracx19(6):599-606, 1968, P.61 s . s.)

An investigation of the working envi- D 10730 roneent in one of the tobacco plants was Worth, G., Smidt, U., and Muysers, K. made as well as laryngological examina- ZUR THERAPIE DER CHRONISCHEN BRONCHITIS. tions among the staff. From 233 persons (THERAPY OF CHRONIC BRONCHIIS.) examined the anneals was gathered and Fortschritte der Medizin86(22):983-6, changes in the upper respiratory ways were troy 21, 196g,-Ugrman lAbs.) described. The analysis of information obtained in comparison with data in the The clinical and pathological criteria literature formed the basis for the fol- in the diagnosis of chronic bronchitis lowing conclusions. (1) Changes in the end the pharmaceutical and surgical upper respiratory tract of workers exposed measures were briefly discussed. Progno- to tobacco dust cannot be considered as sis in chronic bronchitis is dependent serious. (2) Changes of greater inten- upon early diagnosis and treatment. sity can be noticed in the group of tobacco industry workers who smoke, than in the group of nonsmokers employed in simi- D 10734 lar conditions. (Author Abstract.) Staudacher, H. L. and Hoffmann, H. L. NEUE WERE FUR PROPHYLAXE UND IHERAPIE DER CH:1ONISCHEN BRONCHITIS IM ALTER. D 10738 (NEW METHODS FOR PREVENTION AND THERAPY Krumholz, R. A. OF CHRONIC BRONCHITIS IN THE AGED.) A COMPREHENSIVE RESPIRATORY DISEASE PRQ- Zeitschrift fur Oerontologie 1(4) :238- CRAM. Ohio State Medics? Journal 65(2): 52, Jul 19687-Uerman (Abs.) 147-9, rwrIgn. The authors give sn account of the prevention and treatment of bouts of D 10739 chronic bronchitis as the effective types Birath, G. of treatment for old patients. The pre- FUNKTIONELLA OCH STRUKTURELLA FORANDRINGAR vention of bouts consists of a consistent I ANDNINOSORGANEN. (SMOKING AND HEALTH long-term treatment with antibiotics and (2): FUNCTIONAL AND STRUCTURAL CHANGES secretolytic agents during the damp-cold RESPIRATORY ORGANS.) Lakartidningen months of autumn and winter, whereas the 65(44i:4345-50, Oct 30, 1968, Swedish treatment of bouts of the acute exacerba- (Abs. tion of chronic bronchitis consists of an intensive dosage of drug treatment with Facts concerning the health risks of the are combination drug for en adequate- tobacco smoking for tA respiratory or- ly long period of time. Investigations gans are now available from many studies on 81 hospitalized patients with bronchi- of the injurious effects of smoking. tis confirmed the efficacy of the preven- Here are presented in a sh(xt review some tion and treatment of bouts. 40 of the observations made over the past

173 111 D 10739 (continued) D 10762 year on the immediate effects on, among Burrows, B. and Earle, R. H. others, bronchial musculature, c:ial ac- COURSE AND PROGNOSIS OF CHRONIC OBSTRUC- tion, and mucus production, and 01 the TIVE LUNG DISEASE.A Prospective Study strucsural changes that take place in the of 200 Patients. New En /and Journal of broncnial epithelium, the mucus gland, Medicine 280(8):397=T , eb2a, 1969. and the lung. The risks in relation to cigarette consumption for bronchitis, emphysema, and bronchial cancer, are pre- D 10775 sented by means of morbidity and mortali- Palzer, A-n and Thomson, M. L. ty statistics. BOD( PLETHYSMOGRAPHIC MEASUREMENTS OF AIR- WAY CONDUCTANCE IN OBSTRUCTIVE PULMONARY DISEASE. American Review of Respiratory D 10743 Disease 99(2):194-274777b79t9. Lord, G.P. THE EXPIRATORY FLOW VOLUME CURVE IN LOCAL- IZED AIRWAY OBSTRUCTION.Journal of the D 10776 Maine Medical Association g75-(Trir87.707 Ishikawa, S., Bowden, D. H., Fisher, V., :117r9M7---- and Wyatt, J. P. THE 'EMPHYSEMA PROFILE' IN TWO MIDWESTERN CITIES IN NAITH AMERICA. Archives of D 10748 Environmental Health 18(4)=1177q57 Petty, T. L. and Nett, L. M. Mg. PATIENT EDUCATION AND EMPHYSEMA CARE. Medical Times 97(2):117-30, Feb 1969. D 10779 Rylander, R. D /0751 ALTERATIONS OF LUNG DEFENSE MECHANISMS Loudon, R. G. AGAINST AIRBORNE BACTBRIA. Archives of COUGH IN HEALTH AND DISEASE. In: Pro- Environmental Health 18(4):55T=5775r ceedings of the Tenth Aspen Emphysema 1969. Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in Chronic Obstruc- tive Lung Disease.U.S. Department of D 10780 Health, Education, and Welfare, Public Biersteker, K. Health Service, Washington, D.C., Public AIR POLLUTION AND SMOKING AS CAUSE OF Health Service Publication 1787, 1968, BRONCHITIS. Archives of Environmental pp. 41-53. Health 18(4):531-5, gpF-1769.

D 10752 D 10787 Green, G. M. Gross, P. and deTreville, T. P. PATHOPHYSIOLOGY OF THE ALVEOLAR EMPHYSEMA AND PNEUMOCONIOSIS. Archives MACROPHAGE SYSTEM. In: Proceedings of of Environmental Health 18(3):340-9, Mar the Tenth. Aspen Emphysema Conference Aspen, Colorado, Jun 7-10, 1967, Current Research in Chronic obstructive Lung Disease. U.S. Department of Health, D 10794 Education, and Welfare, Public Health Erkstam, G., Kiviloog, J., and Ostling, E. Service, Washington, D.C., Public ALPHA-1-ANTITRYPSIN DEFIC;ENCY AND CHRON- Health Service Publication 1787, 1968, TU-TULMONARY DISEASE. Scandinavian Jour- nal of Respiratory Diseases 49(4171MT, PP. 463-80. rm. D 10753 Howard, P. D 10801 ACUTE EXACERBATIONS AND THE FALL OF FEV Boudik, F., Herles, F., Teichman, V., IN CHRONIC OBSTRUCTIVE AIRWAYS DISEASE. Macholda, F., Horacek, F., and Kaufmann, P. In: Proceedings of the Tenth Aspen C. Emphysema Conference on Current Research VYSKYT CHRONICKE BRONCHITIDY V MESTSKEM in Chronic Obstuctive Lung Disease. U.S. OBVODU.Nektera Data Epidemiologicke Department of Health, Education, and Wel- Studie Chronicke BronAllitidy a Cor Pul- fare, Public Health Service, Washington, monale v Praze 2.(INCIDENCE OF CHRONIC D.C., n. d., pp. 461-9. BRONCHITIS IN A 'DOWN DISTRICT. Some Data on Epidemiological Studies of Chronic Bronchitis and Cor Fulmonale.) Caso Is Iekaru Ceskych 108(1):12-9, 1969, -zec 177a77 D 10801 (continued) D 10803 (continued) In 1964 -1965, epidemiological whether there were more habitual smokers studies were undertaken in Prague 2 among them than in this investigated to test the frequency of chronic population could not be answered. Still, bronchitis and pulmonary heart it is worth noting that of 42 patients among 8,292 males born during 1898- between the age of 35 and 65 years 1913. Chronic bronchitis (chronic for which we have data, 37 were habitual cough and expectoration + 2 years) was smokers. found in 31.77 percent of the subjects. A statistically significantly higher frequency of respiratory symptoms was D 10805 found among cigarette smokers, as Kirbel, P. (Project Director). compared to the nonsmokers. These data A MULTIDISCIPLINARY REHABILITATION were confirmed by ventilation data (FEV PROGRAM FOR PATIENTS WITH CHRONIC 1.0 and PEF). A statistically OBSTRUCTIVE PULMONARY DISEASE. significantly higher frequency of Albert Einstein Medical Center, Moss respiratory symptoms was also found Rehabilitation Hospital and the Public among individuals, in whom the change Health Service (National Center for in occupation (duration exceeding 4 Chronic Disease Control), Philadelphia, years) was associated with a shift from Pa., Supported by Grant No. 29426, May the social group of mental workers to 15, 1968, 69 pp. the social group of manual labourers. (Author Abstract) D 10807 Buturlin, V.V. D 10803 LACTOT4 NKEKOTONEC6EI1E V1 06 3FNAE144A01141 Dappen, C., Bucher, U., and Scherrer, M. XPC0-144ECKVX HECnEW43444ECKW 3A6011EBArill4 BEITRAO ZUR KLINIK DER BRONCHCHRHO. DEMO( Y 11114 YKTBEttiOr0 TPYAA. STATISTISCHE UNTERSUCHUNGEN AM KRANKENGUT DER MEDIZINISCHEN KLINIK DER UNIVERSITAT BERN. (CONTRIBUTION CHASTOTA I NEKOTORYE SVEDENIYA OMB 10 THE CLINIC OF BRONCHORRHEA. EPIDEMIOLCOI/ KHRONICHESKIKH STATISTICAL INVESTIGATION OF PATIENTS NESPETSIFICHESKIKH ZABOLEVANIY OF THE UNIVERSITY OF BERN MEDICAL LEOKIKH U LITS UMSTVENN000 TRUDA. CLINIC.) Praxis 58(2):35 -41, Jan 14, (INCIDENCE AND SOME INFORMATION 1969, German s.) CONCERNING EPIDEMIOLOOY OF CHRONIC NONSPECIFIC DISEASES OF THE LUNGS In 1485 patients of the Medical IN INTELIECUALS.)Telapavticheskii Clinic of the University of Berne Arkhiv 40(11):57-60, 1968; Russian the frequency of the symptom bronchor- (Abs.) rhea (for at least two years continually or Interruptedly cough and phlegm) was Frequency of chronic nonspecific studied. 118 (7.9 percent of the diseases of the lungs among intellect- patients suffered from it, 96 were men. uals who had been under dispensary In 58 cases the unspecific airways observation for many years was studied. disease that led to the bronchorrhea Chronic pneumonia was revealed in gave rise to hospitalize the patient. 1.81 percent, chronic bronchitis in The patients with bronchorrhea had a 1.16 percent, nonspecific pneuro- mean age of 54.S years and 61 of them sclerosis in 0.5 percent. Moreover, had suffered more than ten years from port- tuberculous pneumosclerosis was it. In 82.8 percent of the patients revealed in 0.26 percent and adhesive with bronchorrhea, in which the pleurisy in 0.54 percent. The average pulmonary function was tested, there age of patients with chronic diseases was found an airways obstruction and of the lungs was higher than that in in 72.5 percent a positive response to healthy individuals.The percentage administered Isoprenaline. 5.9 percent of undernourised persons among of the patients with bronchorrhea patients with pulmonary diseases proved moreover suffered from bronchial cancer, to be the same as in healthy individuals. 24.4 percent from a pulmonary tuberculosis Excessive nourishment among patients with (active or inactive) and 11.9 percent from pulmonary diseases was encountered as a sinusitis. According to Gsell in a frequently as among patients with diseases rural Swiss community 60 percent of all of other systems and organs and much men between 35 and 60 year., of age were more frequently than in health/ patients habitual smokers. Since in almost one- (apparently due to the older age of these fourth of our male patients with patients as compared to healthy ones). bronchorrhea indications of the smoking Influenza, catarrh of the upper habit were lacking, the question of respiratory tract and angina in the

175 D 10829 D 10807 (continued) anamnesis of patiem,with chronic In this article are described the diseases of the lungs was encountered most important biochemical results of more often than in healthy persons and the pathological bronchial secretion patients with other diseases, still in various forms of bronchitis. Accord- greater difference wal observed in the ing to their significance it is incidence of pneumonia ar'4 acute particularly descended to the findings bronchitis sustained in tne past (in of the secretion in chronic bronchitis. patients with chronic diseases of the Hereby the quantitative relations both lungs -75.2 percent, - in healthy ones - oP the inorganic constituents, such as 23.1 percent). Among patients with Na, K, Ca, P, and of the organic chronic diseases of the lungs there substances, such as proteins, parts and were more smokers than among healthy components of carbohydrates, lipoids, persons and those With other diseases and amino acids are included. In our own (correspondingly 60 percent and 45 per- examinations of bronchial secretion got cent). (Author Abstract) bronchoscopic:Aly the protein contents in patients with chronic bronchitis was on the same level as in patients with D 10817 laryngectomy performed a longer time ago Nikulin, K. G., Kostina, V. V., who served as compar'tive series in Chernysheva, N. I., Zhichina, A. I., default of normal secretion. There was MalTtseva, A. L., Kitayeva, N. D., also no significant difference between Samochernova, L. I., VOronkova, A. V., the secretion of patients with bronchitis Vorontsov, N. 1., Yarygina, V. Ya. and the control group mentioned concerning the hexosamine contents. However, 0:0619110Cn1 TE41.341 0 XR1414ECi09CHUTE04K,N600,-0( the total hexoses in the secretion of 3/5.6010344,0 nEriM 8 N0.310410:803PACRect rPATIAx. patients with bronchitis were found in ca. three-fold quantity compared with the OSOBENNOSTI TECHENTYA KHRONICHESKIKH secretion of patients in 1,hom some time NESFETSIFICHESKIKH ZABOLEVANIY ago a laryngectomy was performed. This LEGKIKH V RAZLICHNUM VOZRASTNYKH difference is highly significant. (Auth- (FEATURES PECULIAR TO THE GRUPAKH. or Abstract) COURSE OF CHRONIC NONSPECIFIC DISEA4ES OF THE LUNG IN DIFFERENT AGE GROUPS.) Klinicheskaia Meditsina 46(12)u78 -86, bec 1968, Russian (Ws.) D 10851 Holland, W. W. The paper contains information on CHRONISCHE BRONCHITIS UND LUNGENEMPHYSEN. the incidence and clinical forma of (CHRONIC BRONCHITIS AND LUNG EMPHYSEMA.) chronic nonspecific disesss of the InSchievelbein, H. (Editor). Nikotin: lungs in 2754 patients of different age Pharmakologie and Toxikologie des groups. The authors noto the prevalence Tabakrauches. Stuttgart (West Germany), of restricted pneumonic forms at a Georg Thieme Verlag, 1968, pp. 230-41., young age, diffuse bronchitic and mixed German (Abs.) forms in advanced age.Spasm of bronchi in young and mature age is encountered The relationship between smoking more frequently, In advanced age there and chronic bronchitis and emphysema in prevails restricted disturbance of Great Britain was reviewed.The review bronchial patency and asthmatic state is included the following studies: combined with left-ventricular Histopathological changes in the respir- insufficiency due to concomitant coronary atory tract in the lung parenchyma in- cardiosclerosis. In advanced age there duced by tobacco smoke; effect of smoking is seen right-ventricular insufficiency on lung function; relative effect of mostly in the portal system. (Author smoking and other factors (urban and Abstract) rural); relationship or respiratory symptoms to smoking; and possible causal factors which may participate in the D /0829 etiology of chronic bronchitis. Several Kohler, H. tables show the incidence of bronchitis DAS FATHOLOGISCHE BRONCHIALSE:3UT BEI and lung emphysema in 40 to 59-year-old VERSCHIEDENEN BRONCHITISFORMEN. male postal and telephone workers in (PATHOLOGICAL BRONCHIAL SECRETION IN London, in 3 rural English towns and VARIOUS FORMS OF BRONCHITIS.) in 3 American cities on the basis of Zeitschrift fur die Oesamte Inhere their smoking habits. Medizin 23C2677675§:15, Oct 17,-1 &8, TiFFEET-(Abs.) D 1C865 D 10942 (continued) Pistawka, H. J. Medical Research Council. The investiga- CHRONIC AIRWAY OBSTRUCTION. Current tion included measurement of vital Thera_p :99-104, 1969. capacity, forced expiratory volume, peak expiratory flow rate, and chest x-rays. Fifty-four percent were smokers, 18 percent former smokers, and D 10867 28 percent had never smoked. One Greenblatt, M. and Rijhsinghani, K. hundred and nineteen with emphysema had COMPARATIVE CYTOPATHOLOGIC ALTERATIONS lowPr ventilation values than the INDUCED BY ALKYLNTTROSAMINES IN NASAL others; analogous observations were EPITHELIUM OF THE SYRIAN HAMSTER. made of heavy smokers in comparison Journal of the National Cancer nnstitutr. with nonsmokers. A significant correlation was observed between the quantity of tobacco consumed end depth of inhalation with the severity of D 10882 cough and expectoration. Former Journal of the American Medical Associa- smokers, more often than nonsmokers tion. complained, of cardiac difficulties, 'KEY' TO CHRONIC LUNG ILLS ELUSIVE. which coupled with cough and expectora- Journal of the American Medical Associa- tion, may have influenced discontinuance tion 207MTI626, Mar 3,)7g17 of smoking. In former smokers an improvement in cough and expectoration Was often coupled with an improvement in D 10884 obstruction of the respiratory tract. Lowe, C. R. INDUSTRIAL BRONCHITIS. British Medical Journal 1(5642):463-8, Feb 22, D 20960 1969. Winkelstein, W., Jr. and Kantor, S. RESPIRATORY SYMPTOMS AND AIR POLLUTION D 10891 IN AN URBAN POPULATION OF NORTHEASTERN Davidson, J. M. and Macleod, W. M. UNITED STATES. Archives of Environmental PULMONARY ALVEOLAR PROTEINOSIS. Health 18(5):760-7, May on. British Journal of Diseases of the Chest 6311):13-28, Jan 19E9. D 10965 Asmundsson, T. and Kilburn, K. H. D 10902 SURVIVAL OF ACUTE RESPIRATORY Barclay, W. R. FAILURE. Annals of Internal AXIOMS ON CHRONIC PULMONARY DISEASE. Medicine 70(3):171-65, Mar T969. Hos itel Medicine 5(1):70-1, 75-9, an D 10969 Lord, G. P., Gazioglu, K., and D 10919 Kaitreider, N. Mulcahy, R. THE MAXIMUM EXPIRATORY FLOW-VOLUME CIGARETTE SMCKING AND CORONARY HEART IN THE EVALUATION OF PATIENTS WITH DISEASE. Medical News (532):7, Feb LUNG DISEASE. American Jomlnal of 14, 1969. Medicine 46:72477M798T-----

D 10942 D 10977 Jancik, E. Albert, H. E., Lippman, M., and LINE EPIDEMIOLOGISCHE STUDIE UBER Briscoe, W. CHRONISCHE BRONCHITIS AUS BRNO, THE CHARACTERISTICS OF BRONCHIAL TSCHECHOSLOWAKEI. (AN EPIDEMIOLOOICAL CLEARANCE IN HUMANS AND THE EFFECTS STUDY OF CHRONIC BRONCHITIS IN BRNO, OF CIGARETTE SMOKING. Archives of CZECHOSLOVAKIA.) Praxis der Pneumologie Environmental Health 16(5J:738-55T vereini t mit der Tubeikungearzt Play 1469. 2 : -8, TO T13871TWEER1Als.T The study begun in 1968 covered D 10978 2,736 male inhabitants (92 percent of Carnow, B. W., Lepper, M. H., Shekelle, a Brno district) between the ages of R. B., and Stamler, J. 40 and 64 years and followed the CHICAGO AIR POLLUTION STUDY. SO2 guidelines recommended by the British Levels and Acute Illness in Patients

177 181 D 10978 (continued) D 11038 (continued) with Chronic B%onehopulmonary Disease. obstructive chronic bronchitis are stated Archives of Environmental Health in 21 percent, among nonsmokers only in 18(5): 768-46, -Fey 1969. 4.4 percent. Of 215 foundry workers exposed to dust at their working place, 26 rercent show chronic bronchitis, of D 11010 their 230 Colleagues not exposed to dust Simonsson, BO. G. only 18 percent. In 15.1 percent of the STUDIES ON CHRONIC BRONCHITIS. Goteborg, total group (among nonsmokers only in 4.4 Sweden, The Pulmonary Function Laboratory percent) is there a bronchial flow and the University Lung Clinic, resistance above 3 cp/WS/1 sec. After Renstromska Sjukhuset, 1965, 32 pp. 20-30 years work at a place with heavy contamination of the air an increase of 10 to 20 percent in the resistance values D 11026 of 3.0 cm/WS/1 sec. and more can be Martin Santos, F. J. demonstrated. A similar accumulation of EXPERIFNCIA CLINICA CON UNA ASOCIACION increased obstructions of the respiratory DR ERITROMICINA, TETRACICLINA, SULFA- tract is .:omputed after a daily smoking METOXI-PIRIDAZINA, DEXAMETASONA Y of 20 cigarettes for 30 years.The BALSAMICOS. (CLINICAL EXPERIENCE WITH A number of cases of chronic bronchitis COMBINATION OF ERYTHROMYCIN, TETRACYCLINE, increases earlier with the augmenting SULFAMETHOXY-FYRIDAZINE, DEXAMETHASONE influence of professional exposure to AND BALSAMICS.) Medicine Es nola 60 dust, than the number of pathological (354):180-92, Sep 1968, Span s (Abs.) flow resistances.

In 22 cases with infectious respiratory diseases, or with bronchopulmonary D 11039 component, the possible therapeutic Sawicki, F., Steczkowski, J., Jedrychowski, effects of Bio-Exazol (Andreu-Dif) Were W., and Maternowska, W. studied. The administration of the PRZEWLEKLE NIESWOISTE CHOROBY UKLADU medicament was carried out by injection ODDECHOWE00 WSROD MIESZKANCOW KRAKOWA. (intramuscular route) every 12 or 24 III. Wstepne Badanie Terenowe. hours, according to the disease stage, (CHRONIC NONSPECIFIC RESPIRATORY and the results showed a quick regression DISEASES IN THE CITY OF CRACOW. of the symptomatology with an excellent III. Pilot Study.) Przeglad therapeutic response.There was not any Epideriologicz)" u 22(171361,14, 1968, case w,th site effects, and the tolerance PolisH (Abs. at the site of injection was very good in spite of the number of injections In April and May 1966, the pilot administered. (Author Abstract) study was carried out in one of the districts of the city of Cracow, based on a randomly selected sample of 200 D 11038 dwellings and 574 permanent inhabitants. Fruhmann, 0., Barth, M., Bergstermann, H., From the selected sample, 91 percent of Kouba, U., and Fuchs, O. the dwellings and 90.2 percent of the ARBEITSMEDIZINISCHE UNTERSUCHUNGEN persons were examined. Chest roentgeno- 'OBER CHRONISCHE BRONCHITIS, USER grams, spirometric data, body height and BYSSINOSE UND FUR EINE ALLGEMEINE weight were obtained for 63 percent of GESUNDHEITSVORSOROE. (INDUSTRIAL, the persons in the sample. On the basis MEDICAL STUDIES OF CHRONIC BRONCHITIS, of the adopted diagnostic enteria, BYSSINOSIS, AND IN CONNECTION WITH chronic bronchitis syndrome was diagnosed OENERAL PREVENTIVE MEDICINE.) Mvnchener in 17.8 percent of the persons (24 percent Medizinische Wonhenschrift 111(n): of the men and 13 percent of the women). 552-64, Mar 7, :969, German (Ab.r.) In the course of the pilot study, a number of additional, methodologic, Whole-body plethysmography Improves studies were made with the purpose of the early diagnosis of an obstructive cssessing the sources of errors biasing bronchial disease. Knowledge of the flow the results. (Author Abstract). resistance in the bronchi is necessary for the assessment of a capacity per second below 70 percent of the maximum D 11049 respiratory volume and for the evaluation Krstic, S. of the maximum respiration time volume KRONICNE NESPECIFICNE BRONHOPNEUMOPATIJE. measured below 70 percent of the minimum (CHRONIC NONSPECIFIC BRONCHOPULMONARY value required. Among 1,000 workers of a DISEASES.) Anali Rolnice 'Dr. M. metal work (mean age: 42.2 yearn) the Stojanovic' T(npler7eriT"T8):7-20, 1968, anamnestic and clinical symptoms of a non- Serbo-Croation (Abs.)

148 D 11049 (continued) D 11141 Burton, P. A. and Dixon, M. F. Since 1965, the author has been A COMPARISON OF CHANGES IN THE MUCOUS investigating apparently unspecific GLANDS AND GOBLET CELLS OF NASAL, SINUS, bronchopneuMonopethiee, chronic AND BRONCHIAL MUCOSA. Trax 24(2): bronchitis and pulmonary emphysema being 180-5, Mar 1969. of most common occurence. Medical examinations should include the usual manipulations of auscultation and D 11150 percussion, biochemical and immuno- Staneacu, D., Teculescu, D., and Pacuraru, hematological tests, X-rays, and R. apirometric measurements. Bailed on these UNEVEN VENTILATION IN ADVANCED SILICOSIS. test results, diseases are classified as: Internationales Archiv f*.n. Gewerbepatho- I. chronic bronchopathies, like ourrizar-rgra. bronchiectasis; II. localized chronic unspecific pneumonopathies, such as chronic pneumonia; III. diffuse chronic D 11157 diseases of the lungs, auch as diffuse Mitchell, R. S., Walker, S. H., pulmonary fibrosis; IV. chronic diseases Silvers, G. W., Dart, G., and of the pleura, such as chronic adhesive Maisel, J. C. pleuritic; N. secondary cardio-pulmonary FREQUENCY AND SEVERITY OF ANATOMIC disorders and vascular diseases (e.g., EMPHYSEMA IN MEN OVER 40 DYING IN pulmonary embolism); VI. specific TWO DENVER HOSPITALS.Archives diseases of the reapiratory organa 61161 of Environmental Health 18(4): as pulmonary mycosis.Also provided gr7-76, Apr 1969. are 16 tables on the incidence of most of these diseases. D 11158 Freeman, o., Crane, S. C., Stephens, D 11105 R. J., and Furioal, N. J. Gross, P., deTreville, R. T. P., Babysk, THE SUBACUTE NITROGEN DIOXIDE- M. A., Kaschak, M., and Tolker, E. B. INDUCED LESION OF THE RAT LUNG. EXPERIMENTAL EMPHYSEMA: EFFECT OF Archives of Environmental Health CHRONIC NITROGEN DIOXIDE EXPOSURE AND 1814)1609=r2, Apr 1969. OF PA PAIN ON NORMAL AND PNEUMOCONIOTIC LUNGS. U. S. Department of Health, Education, and Welfare, Public Health D 11230 Service, Washington, D. C., Public Health Rodman, T. and Sterling, F. H. Service Publication No. 1787, 1568, PULMONARY EMPHYSEMA AND RELATED LUNG pp. 357-78. DISEASES. Saint Louis, Mo., C. V. Mosby Company, 1969, 468 pp.

D 11109 Epstein, S. W., Fletcher, C. M., and D 11231 Oppenheimer, E. A. Strieder, D, J., Murphy, R., and Kazemi, H. rAILY FEAK FLOW MEASUREMENTS IN THE MECHANISM OF POSTURAL HY?OXEMIA IN ASSESSMENT OF STEROID THERAPY FOR ASYMPTOMATIC SMOKERS.American Review AIRWAY OBSTRUCTION. British Medical of Respiratory Disease 99(5):76077--- Journal 1(5638)3223-57-7M-757-MTT Play 1969-.

D 11127 D 11251 Suhe, R. H., Lumeng, J. L., and Lepper, M. Robertson, D. G., Epstein, S. W., and H. Warrell, D. A. AN EXPERIMENTAL IMMUNOLOGIC APPROACH TO TRIAL OF DISODIUM CROMOOLYCATE IN BRON- THE INDUCTION AND PERPETUATION OF CHRONIC CHIAL ASTHMA. British Medical Journal BRONCHITIS. Archiver of Environmental 1(5643):552-4, Mar 1, 19717 Health 18(4)3364-73, AFF 1969.

D 11260 D 11132 Crusader. Thomson, M. L. and Shnrt, M. D. SMOKING AND EMPHYSEMA.Crusader 35-7, MUCOCILIARY FUNCTION IN HEALTH, CHRONIC May 1969. OBSTRUCTIVE AIRWAY DISEASE, AND ASBESTO- SIS. Journal of Applied Physioluy 26(5):b35-9, May 1969. D 11268 Vargha, G., Poros, Z., and Jozsa, S. DOHANYZAS ES VENTILLACIOZAVAR IDULT TUDOSETEOSEMBEN. Osszehasonlito

179 D 11268 (continued) D 11271 (continued) Vizsgalatok 1000 Betegen. (SMOKING is the percentage of diagnostic errors AND VENTILATION INTERFERENCE IN in identifying nonspecific laryngitis CHRONIC PULMONARY DISEASES. and tracheobronchitis, duo to their Comparative Studies on 1,000 clinical symptoms coinciding with those Patients.)Orvosi Hetilap 109(2): seen in tuberculosis of the larynx 80-2, 1966, ffirigiVian tithe.) and bronchi. The time necJssary to cure nonspecific laryngitis End tracheo- Studies preformed on 690 smokers bronchitis ranges from 1 up to 41 months. and 310 nonsmoking patients afflicted (Author Abstract) with chronic respiratory ailment, have revealed that the obstructive ventilation interference - as expressed by the D 11274 Tiffeneau index - is displaying practical- Reffi, A., Jotti, D., and Baffoni, A. ly a parallel trend with increased FNEUMOTORACE SPONTANEO SACCATO intensity and continuity of the smoking IRREVERSIBILE NEL DECORSO DELLA SILICOSI period. The impairments beyond the age POLMONARE PROGRESSIVA. Osservazione Di 3 of 40 degenerate into chronic debilities. Casi Clinici. (SPONTANEOUS IRREVERSIBLE These observations are derived and con- PNEUMOTHORAX IN THE COURSE OF PROGRESSIVE firmed by the patients of the male ward. PULMONARY SILICOSIS. Observations of In incurring of the phenomena the essen- Clinical Cases.) Rivista di Patologia e tiel factor is manifest by hyperplasia of Clinics della TubeFEBTFEr 3r(5):627=35, the salivary glands on the respiratory rerm-raran kAb6.1 tract caused by smoking. The ratio is 44 percent versus 18 percent among the The authors report on the clinico- abstainers. The ailment is also symptom- radiological and evolutive characteristics atic by the wheezing sound releasTd by of three cases of pulmonary silicosis the patient during the act of breathing. (two massive and one in the initial phase A characteristic inter-relationship, thus of confluence) complicated by chronic far, has not been established between the pneumothorax, limited to the site of vitality of the patient and the effect of the most important pneumoconiotic lesions. smoking. The investigations, however, The absence of a clear symptomatology at have confirmed other documented informa- the initial phase of the disease, the tion that smoking is the prime cause in occasionality of the radiological finding, the initiation of obstructive ventilation the limitation and the irreversibility of difficulties of afflicted sublects. the gaseous collection suggest to prospect Presumably smoking also promotes the a stkLi eneria pathogenesis of these proneness for infections on the respira- pneumoorates allowing the distinction tory (tract and) system. The results from the more frequent and whole pneu- are graphically and tabularly displayed. mothoraces which are always well identified clinically and with a well established pathogenesis, having also a better D 11271 prognosis. (Author Abstract) Satyr, N. A. HECAEL114414EOCNE VAXE03H43600-004Tb1 Y banu-ta TYSEPKYIIE301.1 11E1104.X. D 11281 Chester, E. H., Gillespie, D. G. and Krause, F. D. NESPETS1FICHESKIYE LARINGITY I THE PREVALENCE OF CHRONIC OBSTRUCTIVE TRAKHEOENDOBRON KHITY U BOL1NYKH PULMONARY DISEASE IN CHLORINE GAS TUBERKULEIOM LEGKIKH. (NONSPECIFIC WORKERS. American Review of LARYNGITIS AND TRACHEOENDOBRONCHITIS RespiratorrillreeTie 99(3):335-73, IN PATIENTS WITH TUBERCULOSIS OF Mar 1969. THE LUNGS.) Problem Tuberkuleza 47(2):58-60 Wuea liF77177r D 11288 Examination covered 135 patients, Dines, D. E. whereby nonspecific laryngitis and CHRONIC OBSTRUCTIVE PULMONARY tracheobronchitie were revealed not only DISEASE:Considerations in in tuberculosis, but also in nonspecific Treatment, From Acute Respiratory diseases of the lunge.There was a Failure to long-Term Outpatient tendency towards reduced tuberculosis care. Boletin Asociacion Medico morbidity involving respiratory passages, de PuerrETTFF b0(5):205-137---- but, at the same time, the proportional WiTggr share of detected nonspecific processes in the larynx and bronchi shows but insignificant variations. Still high

180 D 11293 D11363 Holland, W. W., Kasap, H. S., Colley, Oudet, M. P. J. R. T., and Cormack, W. METHODOLOGIE DU DIAGNOSTIC EN PNEUMOLOGIE. RESPIRATORY SYMPTOMS AND VENTILATORY (METHODOLOGY OF DIAGNOSIS IN PNEUMOLOGY.) FUNCTION: A FAMILY STUDY.British Bulletins et Memoires de la Societe Journal of Preventive & SociEr----- Redicale avvrei rgris 1190): ME3rie-n(2)177-64, mirrm. 793780 rT1 ute, French MT:T A critical study of the steps in the D 11294 diagnosis of pneumology has been reported. Cullen, K. J., Welborn, T. A., The present diagnostic procedures are Stenhouse, N. S., McCall, M. G., based upon objective criteria and admit and Curnow, D. H. only a reduced margin of error. This VENTILATORY CAPACITY AND PRODUCTIVE precision in diagnosis permits the use COUGH IN A RURAL COMMUNITY.British of modern information methods. The Journal of Preventive & Social----- research is based upon a study of ROIFT6e778(2):85-90, mirrm. 2912 dossiers of patients admitted to the Hospital during the author's 4 years of service.Tuberculosis and D11301 bronchopulmonary cancers are initially Rankin, J. G., Hale, G. S., Wilkinson, isolated upon diagnosis and the other P., O'Day, D. M., Santemaria, J. N., pneumopathies then arranged into 6 and Babarczy, G. categories accoAing to the radiological RELATIONSHIP BETWEEN SMOKING AND images. One le thus able to structure, PULMONARY DISEASE IN ALCOHOLISM. according to a pragmatic sequence, the Medical Journal of Australia 1(14): collection of the information, and to 730737-A13T-571-967. enter the data on ,:srecoied sheets for eventual transfer to perforated tape for machine handlln4. The adopted D 1130 pragmatic sequence seeks to facilitate Palecek, F. and Rochova-Mrgulaskova, J. the recording of ikformatior. while EXPERIMENTAL EMPHYSEMA IN RATS; AN furnishing a useful plan for clinical ATTEMPT TO INFLUENCE ITS PRODUCTION BY work. GESTAGEN ADMINISTRATION. Phyaiolo la Bohemoelovaca 17(5):443-34, VERJ. D 11364 Katz, F. D 11306 ENFERMEDAD PULMONAR CRONICA OBSTRUCT/VA, Mohanty, P. and Gupta, T. C. (CHRONIC OBSTRUCTIVE PULMONARY DISEASE.) SMOKING HABIT AND PULMONARY VENTILATION Gaceta Medica de Mexico 99(1):67-74, IN ADIVASIS. Indian Journal of 111:11-SFTFITE MT:T.-- physiology and -YRTFEaFFM5r12i3):87-9, 7%11 1968. Chronic bronchitis, asthma, and pulmonary emphysema are defined. From the etiological point of view, it is D 11337 evident that many causal far tors such as Kowalyshyn, T. and Sataline, L. R. infection, smoking, and atmospheric FAMILIAL EMPHYSEMA ASSOCIATED WITH pollution in industrial areas, play a ANTITRYPSIN DEfICIENCY.Diseases of part in the development of chronic the Cheat 55(4)1265-9, Aprrnr- bronchitis. In asthma, although the allergic factor is predominant in cauaing bronchospasms, infections and psychosom- D11341 atic factors must also be taken into Ferris, B. G., Jr. account. Pulmonary emphysema does not CHRONIC LOW-LEVEL AIR POLLUTION. constitute a single pathological entity; Use of General Mortality, and Chronic its major definition is based upon Disease Morbidity and Mortality to structural changes but with regard to its Estimate Effects.Environmental pathogenesis, the obstruction in the Research 2(2):79-87, Feb 1959. aerial tract is not the prime factor in its production but rather the result of lesions in the paremchyma.Tobacco is D 11347 related, directly or indirectly, to the Weill, R., George, R., Schwarz, M., development of emphysema but air pollution, and Ziekind, M. autolmmune phenomena, and metabolic, LATE EVALUATION OF PULMONARY FUNCTION vascular or hereditary factors are also AFTER ACUTE EXPOSURE TO CHLORINE GAS. being investigated.The final verdict American Review of Respiratory indicates that emphysema depends upon UTTFCF6-9;(3173-479, Mar 1967. a combination of factors and upon different mechanisms.

181 /V5 D 11365 D 11369 (continued) Fimiani, R. and Silvestroni, A. rail-shaped longitudinal folds and L'ELETTROCARDIOGRAMM1 NELLE BRONCOPATIE ventilatory changes in lumen caused by CRONICHE. (THE ELECTROCARDIOGRAM IN the tonicity and in those without CHRONIC BRONCHITIS.)Folia Medica $1 bronchitis ecchondromaa. Sexual differ- (2):118-48, Feb 1968, rarraFrMr3.1 ences, external and biomorphous influences appear to be significant. (Author The authors have carried out a study Abstract) for the purpose of ascerttining the value of the electrocardiogram in chronic bronchitis. 1000 cases have been D 11404 observed through complete electrocardio- Jacobs, P. and Robinson, R. graphic teats and, in many cases, through EXPERIENCES WITH DOXYCYCLINE LN THE the comparison of electrocardiographic MANAGEMLNT OF ACUTE RESPIRATORY TRACT tracing with radiologic findings and INFECTIONS. South African Medical tests of respiratory function. On the Jouraal 43(8):206-1M-4107-2, 1969. interpretation of electrocardiographic observations for the diagnosis of right ventricular hypertrophy and chronic D 11409 right heart failure (pulmonary heart) Westerman, D. H., Domm, S.E., Rogers, W. K., have been taken under consideration either and Sorrell, J. L. by those suggested by experts o' the THE EFFECTIVE USE OF BRONCHOSCOPY IN WHO or those recommended by the authors CHRONIC BRONCHITIS. Annals of Otology, that have studied these subjects. From Rhinology and LaryngorFETT8rS):449-58, the examination of the authors, casuistics Jun 196g. the electrocardiogram is normal in 20 percent of the cases; in 2.3 percent there are evident pathognomonic signs of chronic D 11428 pulmonary heart disease according to the Labovitz, J. J., Lebovitz, E., and norms of the WHO in 77.2 percent of all Silverman, 3. D. cases the authors have found PULMONARY EMPHYSEMA. Current Therapy electrocardiographic signs that Show a :113-6, 1969. participation of the right heart.These signs are represented, chiefly in the third and fourth groups by the morpholo- D 11429 gical changes of P waves and by the changes Suhs, R. H. of R/S ratio. On the basis of these CHRONIC BRONCHITIS. Current Therapy results and on the coexistence of a 110-2, 1969. correspondence between these electrocardiographic changes art radiographic and spirographic findingt the authors stated D 11437 that in a high percentage of chronic Baxter, W. D. and Levine, R. S. patients, the electrocardiogram show AN EVALUATION OF INTERMITTENT POSITIVE signs of right heart disease and are of PRESSURE BREATHING IN THE PREVENTION OF valuable aid for a more precise diagnostic POSTOPERATIVE PULMONARY COMPLICATIONS. and prognostic judgment in chronic Archives of Surgery 98(6):795-8, Jun bronchial diseases. (Author Abstract) 1969.

D 11369 D 11438 Reuter, W. and Kohler, H. Kilburn, K. H., Asmundsson, T., Britt, BRONCHUSVERANDERUNOEN IN ABHANGIOKETT R. C., and Carrion, R. VON ALTER UND OBSCHLECHT. (BRONCHIAL EFFECTS OF BREATHING 10 PER CENT CHANGES DEPENDING ON AOE AND SEX.) CARBON DIOXIDE ON THE PULMONARY leitschrift fur Alternsforschung21(3): CIRCULATION OF HUNAN SUBJECTS. 407-12, Dec mr8, German (Abs.) Circulation 39(5):639-53, May 1969. Of 500 bronchoscoped patients, 404 males and 96 females, 265 showed a chronic D 11446 bronchitic ayndrome.The different Pratt, S. A.Finley, T. N., Smith, M. H., incidences of endoscopically visible and Ladman, A. J. changes in the bronchial wall and lumen A COMPARISON OF ALVEOLAR MACROPHAGES AND was calculated statistically. They were FULMONARY SURFACTANT(?) OBTAINED FROM THE observed significantly more frequently in LUNGS OF HUMAN SMOKERS AND NONSMOKERS BY male bronchitics of all age groups than ENDOBRONCH/AL IAVAGE. Anatcmical Record in females. In elderly males with chronic 153(4):497 -507, Apr 19647 bronchitis these wore chiefly parallel

182 g4 D 11464 D 11518 Brunel, M. Medical Officer. TRAITEMENT DE FOND DE LA MALADIE THE "CHESTY" CHILD, CHRONIC BRONCHITIS, ASTFMATIQUE. (FUNDAMENTAL TREATMENT AND CIGARETTES. Medical Officer 121(12): OF ASTHMA.) Revue du Praticien 19(8): 161, Mar 21, 1969. 1135-6; 11394.271-1M4, Flay 71, 1969, French (Abs.) D 11519 Drugs and hygienic measures in the Reid, D. D. treatmen': of asthma were reviewed. THE BEGINNINGS OF BRONCHITIS. Only the nontoxic and less aggressive Proceedings of the Royal Society drugs and techniques were considered in 'inn° Tc the t7( g7T3rr=r; AprT969. this review. In spite of its hazards, the author was enthusiastic regarding cortisone treatment in serious cases D 11525 of asthma. Tobacco was explicitly Croxatto, O. C. and Olmedo, O. forbidden during certain courses of RELACION ENTRE EL "ENFISEMA APICAL 0 treatment. MARGINAL MINIMO" CON EL ENPISMA EXTENDIDO BILATERAL. (RELATION BETWEEN APICAL OR MINIMAL MARGINAL EMPHYSEMA AND D 11470 DIFFUSE BILATERAL EMPHYSEMA.) Medicina Ivanova, I. S., Gayvoronakiy, A. P. 28(5):281-5, Sep-Oct 1968, SpaAishkAbo.) npooEcameokkbe3a5o.rE6as2ceramos/'1$t5 r PA501A1CWBKOMAKTECtiEPC7R10:1 mac. Lungs of one thousand consecutive autopsies performed on patients dyir.g PROFESSIONAL:NY/F. zABOLEVANIVA from different causes were studieU in ORGANCN DYKHANIYA U RABOTAYUSCHIKH order ,o select cases of anatomical V KONTAKTE S SHERSTYANOY PYLM. emphysema and to establish relationships (OCCUPATIONAL DISEASES OF THE between them. One hundred fifty-seven RESPIRATORY OROANG IN WORKERS IN cases of emphysema were found and class- CONTACT WITH WOOL DUST.) Oi Jena ifien in four groups, as follows: group Trudy i Professional1nye La evaniia I, minimal apical or localized peripheral 17117:36-6. Jan 1969, RusTri5PM777 emphysema: group II, more advanced apical or peripheral emphysema; both without Under examination were 191 persons clinical aymptomatology; group III, cica- working under conditions involving tricial emphysema with clinical symptoms exposure to the effects of wool and group IV, diffuse bilateral and gener- dust. Chronic bronchitis was diagnosed alized, noncicatricial emphysema. Mean in 16 (8 percent) cue1 bronchial asthma age of each group was obtained and its In the subjects under examination. differences subjected to statistical Peraons presenting diseases of respira- analysis. There was a significant differ- tory organs (8) underwent clinical ence between mean age of group I and that examination. In the majority of cases of group IV, suggesting that noncicatricial the course of these diseases had a generalized emphysema is the last stage benign nature, but in individual of the peripheral or apical emphysema. Instances more pronounced forms of the This suggestion would be supported by the ailmont developed which led to reduced fact that generalized emphysema shows more work capacity of the patients. (Author advanced lesions at the apices indicating Abstract) a progession of the disease from the apical to the basal zones.(Author Abstract) D 11481 Fullmer, C. D., Short, J. G., Allen, A., D 11532 and Walker, K. Coltoiu, Al., Msteescu, D,, and Lebe, V. SPUTUM OF CHRONIC CIGARETTE SMOKERS- - CONSIDERATII FRIVIND SENSIBILIZAREA LA Rocky Mountain Medical Journal 66(1): TUTUN. (CONSIDERATIONS CONCERNING 42-6, Jan 1969. SENSITIZATION TO TOBACCO.) Viata Medicala 16(0:29-37, Jan 19517-- D 11494 un (Abs.) Lippmann, M. and Albert, R. E. THE EFFECT OF PARTICLE SIZE ON THE The antigenic structure of tobacco REGIONAL DEPOSITION OF INHALED AEROSOLS is discussed, as well as the value of IN THE HUMAN RESPIRATORY TRACT. the skin tests with total tobacco and American Industrial H iene Association tobacco smoke, and of the inveatigation 7FArE-81-3/%3)1257-75,PFny Tun 1969. tests, such as lymphoblastogenesis, Passive transfer, PK, hemagglutination etc. Stress is laid on the role an

183 18/ D 11532 (continued) D 11570 (continued) atopic disposition in sensitizations to and (5) associated therapy (broncho- this allergen, with special reference to 8 dilators, expectorants, diuretics, cardiac cases of cutaneoreepiratory sensitization tonics, oxygen therapy, sedatives, and to tobacco, most of whom were employees weight reduction in overweight subjects.) in a tobacco plant. To conclude, the Therapeutic surveillance measures were authors discuss problems of investigation also outlined. and pathogenesis derived from the study of these patients and from the data In the literature. (Author Abstract) D 11590 Herberg, D. and Utz, G. BEDEUTUNG, DIAGNOSE UND PROGNOSE DER D 11538 RESPIRATORISCHEN INSUFFIZIENZ BEI Ito, K., Iwakura, M., Shirai, J., CHRONISCHEN OBSTRUKTIVEN LUNGENERKRMUNGEN. Hattori, J., and Sugiura, Y. (SIGNIFICANCE, DIAGNOSIS AND PROGNOSIS OF MANSEI KIKANSHI HEISOKUSEI SHIKKAN RkSPIRATORY INSUFFICIENCY IN CHRONIC NO KAMBETSU SHINDAN, MANSEI OBSTRUCTIVE LUNG DISEASES.) KIKANSHIEN 0 CHUSHIN TO SHITS Lebensversicherungsmedizin 21(2):35-8, (DIFFERENTIAL DIAGNOSIS OF CHRONIC Mar 19-69, German tabs./ BRONCHIAL OBSTRUCTIONS, WITH PARTICULAR REFERENCE TOHRONIC The significance of chronic non- BRONCHITIS.) Naika 23(3):406 -13, specific lung diseases is underscored Mar 1969, Japanese(Abs.) by the high mortality and lethality. Sub- jective troubles usually first becomes to be considered in the noticeable when a generalized obstructive diagnosis of chronic bronchitie are dyspnea sets in. The clinical diagnosis discussed, with particular reference of the obstruction is supplemented by to: (1) existing diagnostic criteria spirometry and whole-body plethysmographic such as those of the British Medical investigation. A respiratory insuffi- Research Council; (2) X-ray findings; ciency can be objectified by measurement (3) bacterial and fungal infections of of the blood gases. Prognosis in in- the lung; (4) lung function; (5) hereditary dividual cases depends on the duration abnormalities and predisposition; (6) and progress of the basic disease but a patient's history; (7) air pollution; (8) fundamental ivprovement of a chronic smoking; (9) devel-peentel factors; and obstruction is not to be expected. (10) relations between chronic bronchitis, bronchial asthma and emphysels.As regards smoking, the authors, using D11593 the Brinkmann formula, quote from Vargha, 0. their own observations the following EINE NEUE--AUF DIE BRONCHIALE SCHLEIM- figures for the incidence of chronic DRUSENHYPERPLASIE GEGRUNDETE- bronchitie in different groups: ENTSTEHUNGSTHEORIE FUR DAS OESTRUKTIVE Non-smokers, 0.37 percent; less than EMPHYSEM. (A NEW ORIGIN THEORY FOR 200 on Brinkmann scale, 1.10 OBSTRUCTIVE EMPHYSEMA BASED ON percent; 200-600 on Brinkmann HYPERPLASIA OF THE BRONCHIAL MUCOUS scale, 1.51 percents and over 600 GLANDS.)Acta Medica Academies 4.85 percent. Scientiareirnungrasze26(11 :73 -8, 1969. German (Abs.7

D 11570 Comparative respiratory function- and Liot, F. and Bignon, J. histological inveetigatione were carried CONDUITE THERAPEUTIQUE EN PRESENCE DUNE out in 440 lung-surgery patients.A close BRONCHITE CHRONIQUE. (THERAPEUTIC connection could be established between CONDUCT IN THE PRESENCE OF A CHRONIC the increase of deep mucous glands of the BRONCHITIS.) Therapeutique 45(2): walla of medium-sized bronchi and (1) 193-6, Feb 196D, French (Abs.) obstructive ventilatory disturbances, (2) smoking, and (5) chronic infection of the The differences between chronic bronchi. In 100 smokers, glandular bronchitis, chronic bronchitis compli- hyperplasia could be observed in 44 cated by emphysema, and asthma were patients which was in proportion to the reviewed. The therapeutic measures intensity of the smoking habit; in 100 have been dealt with in 5 categories: nonemokers, glandular hyperplasia was (1) sunpression of the factors of present in only 18 patients.A new bronchial irritation (tobacco and working hypothesis was discussed in which occupational dusts and vapors); (2) a decisive role in the development of anti-infection therapy iintibicotice obstructive emphysema was attributed to and vaccinotherapy); (3 cortisone hyperplasia or dystophy of the deep therapy; (4) respiratory kinesitherapy; mucous glands.

184 D 11611 D 11675 (continued) Shore, S. R. and Aviado, D. M. of 1/28 to a maximum of 1/7; in the HORMONES AND PULMONARY EFFECTS OF emphysemda group without classic TOBACCO.Archives of Environmental electrocardiographic signs of atrial Health 19(1):49-69,-Tur-rg07------enlargement, the ratio was 1/3.2, varying from 1/6 to 1/1. It was ntserved that the P/QRS ratio in the D 11618 nonemphysemia groups was never above Weiner, B. P. and Worth, R. M. 1/7 and in the emphysemia group, always INSECTICIDES HOUSEHOLD USE AND above 1/7. The constancy of these ratios RESPIRATORY IMPAIRMENT. Hawaii suggests that they Lay have value in Medical Journal 28(4):28377-Wr-Apr electrocardiographic diagnosis when 1969. classic parametric criteria are absent.

D 11624 D 11677 Outeran, E., Williams, M. K., Walford, Journal of the American Medical J., and Smith, M. M. Association. CIRCADIAN VARIATION OF F.E.V. IN EMPHYSEMA WARNING INDICATED. Journal SHIFT WORKERS.British Journal of of the American Medical Assoclit751-7- Industrial Medic171 77r2):121-5, 2trerrE):2255, 22x7yun 23, 1967: Apr 1969. D 11682 D 11652 Bouhuys, A., Hunt, V. R., Kim, B. M., and Walker, W. C. and Wright, V. zapietal, A. DIFFUSE INTERSTITIAL PULMONARY FIBROSIS MAXIMUM EXPIRATORY FLOW RATES IN INDUCED AND RISUMATOID ARTHRITIS. Annals of the BRONCHOCONSTRICTION IN MAN.Journal of Rheumatic Diseases 28(3):252"17-101arigN. Clinical Investigation 48:115§-11717-T9rT.

D 11672 D 11684 Lamb, D. Woolcock, A. J., Vincent, N. J., and MUCOUS SECRETION IN HYPERSECRETORY Macklem, P. T. SLATES. dronohes 18(6)1453-65, FREQUENCY DEPENDENCE OF COMPLIANCE AS Nov-Dec 10147---- A TEST FOR OBSTRUCTION IN THE SMALL AIRWAYS. Journal of Clinical Investiga- tion 48:107771717,711707------D 11673 Bouhuys, A., Barbaro, A., Schilling, R. S. F., Van De Woestijne, K. P., D 11699 Kalaysky, S., Kane, 0., Toren, M., Anthonieen, N. R., Bass, H., Oriol, A., and Van Wayenburg, J. Place, R. E. 0., and Bates, D. V. CHRONIC RESPIRATORY DISEASE IN HEMP REGIONAL LUNO FUNCTION IN PATIENTS WORKERS.American Journal of WITH CHRONIC BRONCHITIS.Clinical Medicine 4514;:526-3T -ATF 1T69. Science 35(3):495-511, Dec -ITAT7--

D 11675 D 11729 Miti, L., Moroni, E., and Kassel., V. Harrison, T. R. ASPETT/ ELETTROCARDIOGRAFICI DELL,- TERAPIA DELL,ANGINA PECTORIS. ENFISEMA POIMONARE: IL RAPPORTO P/QRS (ANGINA PECTORIS THERAPY.)Clinics NELIA DIAQNOSI DI INGRANDIMENTO ATRIAIE Terapeutica 45i2):92-115, ApF-307- DESISO. (ELECTROCARDIOGRAPHIC VIEW OF 1968; Italian Abs.) PULMONARY EMPHYSEMA: THE P /QBS RATIO IN THE DIAGNOSIS OF RIOHT ATRIAL Various measures to combat and pre- ENLARGEMENT.) Internexionale vent angina pectoris were reviewed. The di Clinica e Terapla I (22) :1417 -23, dietetic and hygienic measures that MTV -3157-PAT, Italian Abs.) everybody reachir4 a certain age must observe, particularly those already One hundred emphysematous subjects, suffering from cardiac isehemis, were 70 male and 30 female, and 100 non- discussed. The therapy of true angina emphysematous subjects, equally divided was then considered, distinguishing as to sex, were investigated.Twenty of between exertion angina and pre-infarct the emphysemia group were excluded angina, and illustrating the application because of findings of infarct ami of coronary dilators, cholesterol-reduc. ventricular hypertrophy. In the non- ing agents, and anticoagulants.Partic. emphysemia group the average P/QRS War attention was paid to the causative ratio was 1/17, varying from a minimum factors and to the psychological problems

18 D 11729 (continued) D 11767 (continued) of subjects with angina pectoris. With hospital treatment for bronchial regard to the effects of tobacco, most complaints and who could later submit subjesita, after smoking, showed ballisto- to repeated clinical observation cardiographic evidence of cardiac at periods averaging from 2 to 8 compression.Some subjects react to the years. The inhalation technique used inhalation of tobacco smoke with the for the acetylcholine test guaranteed liberation of catecholamines, which in a fair identity of the amount of ac- turn favors coagulation of the blood, and tive substance (1600 gamma) effectively forces a rise in the lipemic level. inhaled by all the patients. The Patients with angina pectoris are advised investigation has shown a close rela- against smoking cigarettes. tionship between the reactivity to acetylcholine and the variations of tha basic Maximal Expiratory Volume D 11749 par Second (VEMS) in the firat ob- Auerbach, O. servation.This relationship seems to EPITELIO BRONCHIALE IN EX-PUMATORI. explain the correlation described as (BRONCHIAL EPITHELIUM IN EXSMOKERS.) classical, between the age of the pa- Minerva Medica 59(79):4136-9, Oct 3, tient and his reactivity to acetyl- 1731177te-7rair(Abs.) choline. The latter has proved to differ in smoking and nonsmoking Seventy-two examokers of cigarettes, patients generally the latter being 72 current cigarette smokers and 72 more receptive than the smokers. This nonsmokers (never smoked) were matched may be explained by a mechanism of in all other respects regarding, age, earlier selection: a number of non- sex, intensity and duration of the smokers may have been people who never smoking habit in smokers and residence smoked or who had abandoned smoking (urban or rural). Epithelial lesions cigarettes because of a general hyper- were present in 97.8 percent of strips reactivity of their respiratory eyatem. of bronchial epithelium from current In comparing the prognostical value of smokers, in 66.6 percent of exemokers the ventilatory and tuasigenic reactivity and only in 25.7 percent of nonsmokers. to acetylcholine in two groups of 31 Each specific type of epithelial alter- patients with an average VEMS, middle ation was found more frequently in the aged and of the same smoking habits, no stripe of current smokers and less fre- relationship hat aeen found between quently in those of nonsmokers. The hyperreactivity to acetylcholine and the percentage for exemokere was midway be- evolutivity rate of pneumoconiosis. tween that of the other 2 groups. The functional degradations mainly the Atypical nuclei were present in 93.2 important degradationsappearedto be percent of stripe from current smokers obviously more frequent in the group of and only in 1.2 percent of those from patients with a markedly high reactivity nonsmokers.All current smokers exhibited to acetylcholine. (Author Abstract) many strips of such cells but they were present only in 36 of 72 ex:smokers and 19 of 72 nonsmokers. Cells with atypical D 11784 nuclei decreased in number after cessation Shambaugh, 0. E., Jr. of smoking.A strong negative correlation EMPHYSEMA, THE INSIDIOUS ENEMY.Archives was found between the presence of cells of Otolaryngology 90(2):121, Aug mr--- with atypical nuclei and those of cells with disintegrating nuclei. D 11797 Toyama, T. D 11767 AIR POLLUTION AND ITS HEALTH ASPECT Minette, A. IN TOKYO AREAS. Asian Medical Journal VALEUR PRONOSTIQUE DE LINYPERREACTIVITE 11(12):5-15, Dec Mir BRONCMIQUEPOURL'ACETYLJHOLINE AU LOURS DS IA BRONCHITE CRRONDWE DES MrNEURS DE CHARBW. (PROGNOSTIC VALUE D 11798 OF BRONCHIAL HYPERACTIVITY FOR ACE- Aronow, W. S. and Swanson, A. J. TYLCHOLINE IN CHRONIC BRONCHITIS OP NON-NICOTINIZED CIGARETTES AND ANGINA COAL MINERS.) Bronches 18i6)1466-88, PECTCRIS. Annals of Internal Medicine Nov-Dec 1968, PFTEZHTrbs. 70(6):1227,MTMET. beauthor proposed to examine the prognoetic functional and D 11839 roentgenological value of ventilatory Melica, A., Cavalli, A., Fabbri, M., and tuseigenic hyperactivity to and Brignani, P. acetylcholine in coal-miners.He LA DOXICICLINA IN PNEUAOLOGIA: utilised a group of ace miners in

186 !90 D 11839 (continued) D 11848 (continued) FROFILASSI E TERAPIA DELLE BRONCO- the morbidity rate was much greater. PNEUMOPATIE. (DOXYCYCLINE IN The externally communicating organs FNEUMOLOOY: PROPHYLAXIS AND THERAPY were for the most part Involved, OF BRONCHOPULMONARY DISEASES.) especially the revAratory system Gazzetta Internazionale di Medicine (bronchitis, lobular pneumonia), the i-Ch71417gitt 7321):1892-72W-RWIT, urinary tract (cystitis, pyelonephritis), ns8, IEajan (Abe.) and the gastro-intestinal tract (div- erticulitis, cholecystitia). In a Treatment with Doxycycline, a relatively high percentage active tuber- tetracycline obtained by hydrogenation culosis was found. In the higher age of metacycline, was investigated in groups the number of simultaneously 55 cases, both male and female, suf- coexisting multiple infections increased. fering from acute, subacute or chronic Men turned out to be more susceptible to bronchitis, and/or pulmonary emphysema multiple infections than women. While at the Institute di Patologia Speciale infections during young age are given of the University of Bologna during considerable attention, there is an 1967 and 1968. Treatment consisted of underestimation of their importance in 1 tablet per day for varying periods old age. (Author Abstract) from 15 days to 3 months.Tolerability was good in all cases and the results favorable. Results of treatment were D 11849 compared with those using other tetra- Julich, H. and Rucker, K. cyclines requiring higher dosage. DER EINFLUSS VON FULMOPEYLLIN AUF DIE KORPERLICHE LEISTUNOSFAHIOKEIT VON KRANKEN MIT LUNOENEMPHYSEM. (THE D 11840 INFLUENCE OF PULMOPHYLLIN OW THE Israel-Asselain, R. PHYSICAL CAPACITY OF PATIENTS WITH

BASES ET CONDUITE DU TRAITEMENT DES PULMONARY EMPHYSEMA,)Deutsche . BRONCHITES CHRONIQUES. (BASIS AND Gesundheitswesen 24(8):3Tr-T-Teb UUIDE FOR THE TREATMENT OF 21-, 1959, German (Abs.) BRONCHITIS.) Maroc Medical 49 523): 237-44, Apr 19g177rench (Abe. After having detected and examined the normal values for the recovery The definition, etiology, neces- quotient and the vital capacity in 196 sity for observing anatomical intact persons, we observed 20 patients alteratIons in the course of chronic suffering from a pulmonary emphysema bronchitis, functional tests and prior to and during a four months' therapy (classical, Antibiotic, treatment with pulmophyllin.During corticoid, climatic and kinesitherapy) this period of treatment the patients were discussed briefly.As preventive were repeatedly examined. Under the measures, the author advocated res- simultaneous intravenous, intramuscular, piratory hygienic rules for everybody, and peroral application the recovery especially those already threatened, quotient rose from 69 percent of the vigorous anti-tobacco campaigns, and normal on the average to 99 percent measures against air pollution in within one month. Under the exclusively cities and industrial plants. peroral application it dropped again to 89 percent during the following 3 months. Under the same conditions the D 11848 vital capacity rose from 38 percent of Geiser, B. and Steinmann, B. the normal on the average to 52 percent, INFEKTIONEN IM ALTER. (INFECTIONS so as to drop down again to 48 percent. IN THE AGED.) Zeitschrift fur Although also other factors exert a Gerontolosie 2(2) :69-85, lgarr969, favorable effect on pulmonary emphysema Oerman tAbe.) patients (e.g. nicotine prohibition, patients' gymnastic exercise), we may The post-mortem findings in a hos- yet conclude owing to the sole medica- pital for chronic disease have been mentous application of pulmophyllin analyzed with regard to the occurrence that this drug helps to improve the of infections (340 cases, 251 patients patients' physical efficiency. Prcbably, more than 60 years old).With the parenteral application is more effective exception of tuberculosis, only second- than the peroral one. (Author A.,stract) ary local infections were found.They were analyzed as to their incidence, distribution to age and sex and D 11851 dependence on preexisting systemic Yablokov, D. D. and Galibina, A. I. lesions caused by old age.The in- SPO-CGIAPtlikR ACTKAN TYEEPOTE3 fluence on the mortality was rather ADWV. unimportant, whereas the influence on BRONKH/AWNAYA ASTMA I TUBERKULEL

187 191 D 11851 (continued) D 11878 LEGKIKA (BRONCHIAL ASTHMA AND Gregg, I. TUBERCULOSIS OF THE LUNG.) Klinicheskaya INFECTION AND CHRONIC BRONCHITIS. Meditsina 46(12):20-8, Dec 1958, A Study Carried out in General iallirrAbs.) Practice.Respiration 26(Suppl.): 16-30, 1969. Examination of 6,000 patients with active tuberculosis of the lungs showed that 27 or 0.45 percent of these D 11879 patients also had bronchial asthma. A Scher, M. further examination of 600 patents with UMWELTSFAKTOREN UND PERSONIICHES VERHAI- bronchial asthma showed that 11 or 1.83 TEN ALS URSACHE VON ERKRANKUNGEN DER percent also had active tuberculosis ATMU4GSORGANE. (ENVIRONMENTAL FACTORS of the lungs. These findings are com- AND PERSONAL BEHAVIOR AS CAUSES OF pared with statistics reported prev- DISEASES OF THE RESPIRATORY ORGANS.) iously in the literature on the Res iration 26(Suppl.):5-15, 1969, coexistence of bronchial asthma and erman rm.) tuberculosis. The effects of air pollution and of the principal components of polluted D 11857 air on the morbidity of chronic bron- Gluckman, J.J. chitis, asthma and lung cancer were L'EMPHYSEME PULMONAIRE. (PULMONARY discussed. Air pollution was recognized EMPHYSEMA.) Gazette des Hopitaux as a serious factor in the development 141(11):341-37757-707-19;4, French of such disorders but the incidence (Abs.) was much greater in smokera than nonsmokers. The incidence of pollen-caused Clinical, radiological, and asthma was also much higher in environ- biological aspects of pulmonary ments with a high sulfur dioxide content. emphysema were very briefly outlined. Carboxyhemoglobin content of the blood of Preventive measures include combat- smokers was much greater than nonsmokers. ting air pollution, occupational Research on identoal and fraternal twins respiratory Irritants, and consumption has shown that chronic bronchitis was of tobacco. not genetically linked but depended upon whether the twins were or were not smokers. The conclusions of the Terry D 11811 Report concerning the effects of smoking Amatunyan, V. G. on the incidence of chronic bronchitis, Balm+ namomorm A PADIPOCTPAHD+10cTb emphysema, asthma and lung cancer were xPOH4ACK000 5POr061TA E Ammon CCP. presented. The author also expressed hie own views on the benefits of discon- VOPROSY VPIDEMIOLOGLE I RASTPROSTRANEN- tinuing smoking on health and life ex- ROST' KHRONICHESKOGO BRONKHITA V pectancy. Measures to reduce air ARMY1NSKOY SSR. (QUESTIONS ON THE pollution would include inatallation of EPIDEMIOLOGY AND PREVALENCE OF expensive industrial devices, improve- CHRONIC BRONCHITIS IN THE ARMENIAN ment of heating syatems, desulfurization SSR.) Zhurnal Eksperimentallnoi 1 of fuel oil, and control of motor vehicles Klinichirracirgeditainy CrgrItir§, and traffic. 1767;t7MTIIntAbs.7 The incidence and severity of chronic D 11907 bronchitis was studied in two populations Kubo, S. in Armenia, one inhabiting a mountainoua AIR POLLUTION AND HEALTH OF ENFANTS AND area and the other a valley. It waa (AILDREN.Asian Medical Journal 12(4): found that the incidence of chronic bron- '!33-47, AprInr, chitis was higher in the mountain area than in the valley, and this despite the fact that the percentage of smokers D 11932 was lees in the mountain population than Putz, C. in the valley population. LA NOCIVITE DES POUSSIERES DE SCORIE THOMAS SUR L'ARBRE RESPERATO/RE ET I/ PREVENTION DES BRONCHO-PNEUMOPATHIES D 11876 (20 ANNEES D'EXfERIENCE DANS LA SIDERUhlIE Bartsch', R. and Regli, J. LUXEMBOURGEOISE). (THE INJURIOUS EFFECT CHRONIC BRONCHITIS IN A RURAL AREA OF THOMAS SCORIA DUSTS ON THE RESPIRA- AND ITS PROGNOSIS.Respiration TORY TREE AND THE PREVENTION OF 26(Suppl.)(251-8, 1969. BRONCHOPULMONARY DISEASES (TWENTY YEARS

188 D 11932 (continued) D 11941 (continued) OF EXPERIENCE IN THE LUXEMBOURG IRON as far as gastrointestinal disturbances INDUSTRY).) Archives des Maladies are concerned, we detected that this fact ProfessionnelTiinReaFF6Nnr/Tavail also applies to herniae in our 110pa- etdeSecurite SoFTale 30(3):1777567--- tients. Over and above, we also consid- Wr-T9b9, French (Abs.) ered the relative frequency of the Sahli venous wreath of varices and hemorrhoids, The author describes the adverse as well as of watch-glass nails, drum- effects of Thomas scoria dust on t'ie stick fingers and senile angiomas. There respiratory apparatus and suggests pre- result starting points for prophylactic ventive measures. Pneumonia ane. bronchio- measures, which are mainly desirable for pathy resulting from Thomas scoria dust preventingaprogredient course of the have decreased markedly in incidence and disease towards a chronic cor oulmonale. severity. However, deaths from broncho- (Author Abstract) pulmonary diseases, including severe pneumonia and acute and chronic bronchitis, remain higher among scoria workers than D 11942 among other workers. Apparently there Mammarella, L., Fischetti, M. and are no trends toward pulmonary sclerosis, Tarsitani, F. emphysema, tuberculosis, or cancer. L'APPARATO RESPIRATORIO ED I MECCANISMI Pneumoconioses and irritations of the DE DIFESA MICROBICA. (THE RESPIRATORY upper respiratory tracts are rare. The APPARATUS AND THE MECHANISMS OF MICRO- improvement of the situation is due to: BIAL DEFENSE.)Annali di Medicine Neville (1) modernization of facilities, which 74(2):125-40,Ma.:7-47a1zgl97-Trirrin-(KEIT7) has brought about a spectacular reduction in the dust; (2) wearing of anti-dust The present knowledge about the masks; (3) medical registration of workers; mechanism of antimicrobial respiratory and (4) treatment of serious pulmonary defense, based on the most recent studies diseases by antibiotics. The scoria and experiments, is summarized. In the worker should receive preventive treatment, nose and upper airway the protection de- including: (1) an examination at the time pends mostly on the interplay of three of recruitment; (2) semiannual examina- factors: deposition, transport and tions; (3) regular radiophotographic exist:11;ton of particulate matter: a kind examinations; and (4) vaccinations for of local inactivation of microbes is also influenza. possible. In the lower respiratory tract more complex and efficient mechanisms are operating such as capture, transport, D 11941 macrophagic action. These mechanisms may Mann, D., Wendekamm, R., Schutz, J., be altered by various conditions (hypoxia, Schulz, K., and Michael, H.-G. alcohol, smoking, etc.). (Author Ab- DIE BEDEUTUNG EINIOER ATIOLOGISCHER stract) MOMENTE BEI DER CHRONISCH-OBSTRUKTIVEN BRONCHITIS. (THE SIGNIFICANCE OF SEVERAL ETIULCOICAL FACTORS IN CHRONIC OBSTRUCTIVE D 11451 BRONCHITIS.) Deutsche Gesundheitswesen Baumann, H. R. 24(191747-50,-AfriT7 T969,Oa -man ZUR BEHANDLUNG DES LUNaENEMPHYSEMS. (Abs. (TREATMENT OF LUNG EMPHYSEMA.) Therapeutische Umschau 25(11)1592-8, In addition to its clinical importance, Nov 1968, GermanU:4;37) chronic-obstructive bronchitis is gaihing an ever increasing importance for occupa- It is important to distinguish tional medicine. For a better differen- clinically between two forms of pul- tiation of the endogenous etiological monary emphysema, the "pink puffer" component at the pathological process the and the "blue bloater". The different authors engaged in directed studies, re- therapeutic measures to improve mus- searching into anamnestia and symptomatic cular respiratory work, bring about signs. The results achieved so far sug- economic respiration, intensify ex- gest a constitutional inferiority or pectoration, reduce disturbances of inferior exposability of the respiratory repartition and t!erthy increase the channels. An endogenous predisposition is tolerance to effort, were discussed. suggested, amongst others, by the accumu- The manner in which the physician can lated occurrence of disturbances which rffer his patient psychological cannot solely be accounted for by exoge- guidance was deemed of great impor- nous factors, such as stomach diseases and tance in therapy. the symptoms of a poor structure of the connective tissue. Besides the significant, well-known differences, as compared to the control groups with intact lungs,

189 193 D 11959 D 12026 (continued) Wilde, W. apparently healthy, male workers non- LANGZEITBEHANDLUNG DES "BRONCHITISCHEN smokers and cigarette smokers.The data SYNDROMS". (LONG-TERM TREATMENT OF THE obtained indicate that squamous metaplasia "BRONCHITIS SYNDROME%) Landarzt 45(12): is more frequent among smokers than non- 573-7, Apr 30, 1969, German74177) smokers, and a clear parallelism does exist between incidence of the lesion and Asth-Med has been administered to the number of daily cigarettes. (Author 125 patients with the bronchitis syn- Abstract) drome for its lung circulation-promoting, secretolytic, antiphlogistic anti- allergic, and cough-serlating properties. D 12030 It was recommended for all phases of Robertson, D. 0., Harrell, D. A., Newton- the syndrome, especially for long- Howes, J. S., and Fletcher, C. M. term therapy and was said to have no BRONCHIAL REACTIVITY TO CIGARETTE AND side-effects even in combination ther- CIGAR SMOKE. British Medical Journal apy. Asth-Med is a specialty prod.st 3(5667):269-7177177,7177677- containing diprophylline, norep:nephrine- suit., diphenylhydramine-HC1, guaiacol/ glycerine ether, and alcoholic extracts D 1.037 of several herbs. Freour, P. and Coudray, P. EPIDEMIOLOGIE DES TROUBLES BRONCRO- RESPIRATOIRES: RECHERCHES SUR UN D 11992 GROUPE DE FEMMES DUNE GRANDE Bouhuys, A., Wolfson, R. L., Horner, D. W., AGGLOMERATION URBAINE.. (EPIDEMIOLOGY Brain, J. D., and Luskin, E. OF H'ONCHORESPIRATORY DISORDERS: BYSSINOSIS IN COTTON TEXTILE WORKERS. RESEARCHES 0'.1 A GROUP OF WOMEN OF A Respiratory Survey of a Mill with Rapid LARGE URBAN POPULATION.) Bulletin Labor Turnover.Annals of Internal de l'Institut National de la Sante et Medicine 71(2):257707-Aug 1959. ae Ta-MEFFEhe medicalra.N7773-77, Wr=rpr 19b9, VeinEffcrEs.)

D 12015 A feminine urban population (Bordeaux), Ball, J. D., Pcery, 0., Clarke, W. G., 30 to 70 years, was investigated regarding Gilson, J. C., and Thomas, J. bronchopulmonary symptomatology and A CONTROL1ED TRIAL OF ANTI-TUBERCULOSIS respiratory insufficiency.A functional CHEMOTHERAPY IN THE EARLY COMPLICATED exploration was carried out for the deter- PNEUMOCONIOSIS OF COALWORKERS.Thorax mination of vital capaoity, m?. imam ex- 24(4):399-406, Jul 1969. piratory second volume and Tiffeneau Coefficient. An important bronchopulmonary syndrome was found in 12.33 percent D 12018 and a slight syndrome in 17.53 percent of Howard, P. and Astin, T. W. the subjects. The incidence of the eyn- PRECIPITOUS FALL OF THE FORCED EXPIRATORY dromea inc.:need with age and with in- 7OLUME. Thorax 24(4):492-5, Jul 1969. creasing consumption of tobacco. The incidence of allergic and pleural antecedents in the development of severe D 12026 dyspneas was very significant.There was Maltoni, C., Carretti, D., Canepari, C., a greater incidence of syndromes in aNd Ghetti, G. retired individuals. Among the actively INSIDENZA DELIA METAPLASIA SQUAMOSA employed, the incidence was lower among DELL'EPITELIO RESPIRATORIO IN RAPPORT° management officials, merchants, artisans, AL FUMO DI SIGARETTA. STUDIO CITOLOOICO and clerical employees than in the manual SU 1000 DRDIVIDUT DI SESSO MASCHILE workers but the differences were not APPARENTEMENTE SANI. (INCIDENCE OF statistically significe..t. The results SQUAMOUS METAPLASIA OF THE RESPIRATORY were compered with thole of other French EPITHELIUM IN RELATION TO CIGARETTE and foreign populations. SMOKING. CYTOLOGICAL STUDY ON 1,000 APPARENTLY HEALTHY MALE INDIVIDUALS!) Cancro 21(4)1349-56, 1968, Italian (Abs.) D 12054 U. S. Department of Health, Education, and After a short review of the literature Welfare, Public Health Service. on the relationship between squamous CURRENT RESEARCH IN CHRONIC RESPIRATORY mataplasia of respiratory epithelium, lung DISEASE. Eleventh Aspen Emphysema carcinoma and tobacco smoking, the results Conference.Aspen, Colorado, Jun 12-15, are reported of a cytological investiga- 1968. U. S. Department of Health, Educa- tion performed on the sputum of 1,000 tion, and Welfare, Public Health service, Wrshington, D.C., Public Health Service Publication No. 1879, 1969, 355 pp.

190 ) 94 D 12065 D 12059 (continued) lauweryns, J. M. and Bourgeois, N. Disease. U. S. Department of Health, NEONATAL HYALINE MEMERANE DISEASE: Education, and Welfare, Public Health LIGHT AND ELECTRON MICROSCOPICAL Service, Washington, D.C., Public Health STUDIES. In: Proceedings of the Service Publication No. 1879, 1969, Eleventh Aspen Emphysema Confererce, pp. 103-14. Aspen, Colorado, Jun 12-15, 1968, Current Research in Chronic Respiratory Disease. U. S. Department of Health, D 12063 Education, and Welfare, Publio Health West, J. 8., Glazier, J. 8., Hughes, Service, Washington, D.C., Public Health J. M. B., and Maloney, J. E. Service Publication No. 1879, 1969, EFFECT OF GRAVITY ON THE MORPHOLOGY OF pp. 3 -32. PULMONARY CAPILLARIES AND ALVEOLI. In: Proceedings of the Eleventh Aspen Emphysema Conference, Aspen, Colorado, D 12066 Jun 12-15, 1968, Current Research in Evans, M. J., Bile, R. P., Hackney, J. D. Chronic Respiratory Disease. U. S. AN ELECTRON MICROSCOPIC STUDY OF CELLULAR Department of Health, Education, and RENEWAL IN PULMONARY ALVEOLAR WALLS OF Welfare, Public Health Service, NORMAL AND OXYGEN POISONED MICE. In Washington, D.C., Public Health Proceedings of the Eleventh Aspen Service Publication No. 1879, 2969, Emphysema Conference, Aspen, Colorado, pp. 135-7. Jun 12-15, 1968, Current Research in Chronic Respiratory Disease. U. S. De- partment of Health, Education, and D 12064 Welfare, Public Health Service, Washing- Turino, O. M., Edelman, N. H., Senior, R. ton, D.C., Public Health Service M., Richards, E. C., and Fishman, A. P. Publication No. 1879, 1969, pp. 33-40. EXTRAVASCUIAR LUNG WATER IN COR PULMONALE. In: Proceedings of the Eleventh Aspen Emphysema Conference, Aspen, Colorado, D 12067 Jun 12-15, 1968, Current Research in Niden, A. H. Chronic Respiratory Di . U. S. EFFECTS OF AMMONIA INHALATION ON THE Department of Health, Education, and TERMINAL AIRWAYS. In: Proceedings of Welfare, Public Health Service, the Eleventh Aspen Emphysema Conference, Washington, D.C., Public Health Aspen, Colorado, Jun 12-15, 1968, Service Publication No. 1879, 1969, Current Research in Chronic Respiratory pp. 139-50. Diaease. U. S. Department of Health, Education, and Welfare, Public Health Service, Washington, D.C., Public D 12065 Health Service Publication No. 2879, Boren, H. O. 1969, pp. 41-4. DEPOSITION AND REMOVAL OF CARBON PARTICLES BY FLUOROCARBON BREATHING. In: Proceed- ings of the Eleventh Aspen Emphysema D 12068 Conference, Aspen, Colorado, Jun 12 -15, Penman, R. W. B. 1968, Current Research in Chronic REGIONAL AND OVERALL VENTILATICN-PERFUSION Respiratory Disease.U. S. Department RATIOS IN NORMAL SUBJECTS AND PATIENTS of Health, Education, and Welfare, WITH CHRONIC LUNG DISEASE. Ins Proceed- Public Health Service, Washington, D.C., ings of the Eleventh Aspen Emphysema Public Health Service Publication No. Conference, Aspen, Colorado, Jun 12-15, 1879, 1969, pp. 153-7. 1968, Current Reeearch in Chronic Respi- ratory Disease. U. S. Department of Health, Education and Welfare, Public D 12066 Health Service, Washington, D.C., Pratt, P. C. Public Health service Publication No. INTRAPULMONARY RADIAL TRACTION: MEASURE- 1879, 1969, pp. 63-73. MENT, MAGNITUDE AND MECHANICS. In: Proceedings of the Eleventh Aspen Emphysema Conference, Aspen, Colorado, D 12069 Jun 12-15, 1968, Current Research in Sekihara, T., Olson, D. C., and Filley, Chronic Respireto..y Disease. U. S. O. F. Department et Health, Education, and AIRFLOW REGIMES AND GEOMETRICAL FACTORS Welfare, Public Health Service, IN THE HUMAN AIRWAY. InProceedings Washington, D.C., Public Health of the Eleventh Aspen Emphysema Confer- Service Publication No. 1879, 1969, ence, Aspen, Colorado, Jun 12-15, 1968, pp. 1E9-81. Current Research in Chronic Respiratory

191 195 D 12067 D 12072 Ricketts, H. J. and Carrington, C. B. Schaefer, K. E. EXPERIMENTAL BRONCHIAL ARTERY THE CO2-INDUCED HYALINE MEMBRANE DISEASE OCCLUSION IN SHEEP. In: Proceedings of AS A BIOLOGICAL MODEL FOR THE STUDY OF the Eleventh Aspen Emphysema Conference, LUNG CELL INJURY AND REPAIR.In: Proceed- Aspen, Colorado, Jun 32-15, 1968, ings of the Eleventh Aspen Emphysema Current Research in Chronic Respiratory Conference, Aspen, Colorado, Jun 12-15, Disease. U. S. Department of Health, 1968, Current Research in Chronic Respi- Education, and Welfare, Public Health ratory Disease.U. S. Department of Service, Washington, D.C., Public Health, Education, and Welfare, Public Health Service Publication No. 1879, Health Service, Washington, D.C., Public 1969, pp. 187-9. Health Service Publication No. 1879, 1969, pp. 321-2.

D 12068 Vatter, A. E. (Moderator). D 12073 LUNC MORPHOLOGY. In: Proceedings of the Echt, R. Eleventh Aspen Emphysema Conference, ESTIMATIONS OF PULMONARY SURFACE ACTIVITY Aspen, Colorado, Jun 12-15, 1968, Current IN SEDENTARY AND EXERCISED RATS. In: Research in Chronic Respiratory Disease. Proceedings of the Eleventh Aspen U. S. Department of Health, Education, Emphysema Conference, Aspen, Colorado, and Welfare, Public Health Service, Jun 12-15, 1968, Current Research in Washington, D.C., Public Health Chronic Respiratory Disease. U. S. Service Publication No. 1879, 1969, Department of Health, Education, and pp. 199-212. Welfare, Public Health Service, Washington, D.C., Public Health Service Publication No. 1879, 1969, D 12069 pp. 323-31. Loudon, R. G. DETERMINANTS OF EXPIRATORY AIRFLOW. In: Proceedings of the Eleventh Aspen D 12074 Emphysema Conference, Aspen, Colorado, Graf, P. D., Wolfe, W. 0., and Nadel, J. A. Jun 12-15, 1968, Current Research in NEW TECHNIQUE FOR OUTLINING AIRWAYS Chronic Respiratory Diaease. U. S. RADIOLOOICALLY USING POWDERED TANTALUM. DePartment of Health, Education, and In: Proceedings of the Eleventh Aspen Welfare, Public Health Service, Emphysema Conference, Aspen, Colorado, Washington, D.C., Public Health Jun 12-15, 1968, Current Research in Service Publication No. 1879, 1969, Chronic Respiratory Disease. U. S. PP. 275-85. Department of Health, Education, and Welfare, Public Health &mice, Washington, D.C., Public Health D 12070 Service Publication No. 1879, 1969, Emnanuel; G. E., Rosenbluth, A., Ansari, I., pp. 333-43. Villano, R., and Carducci, R. EVIDENCE OF ACTIVE ALVEOLAR CLOSURE IN THE HUMAN LUNG. In: Proceedings of the D 12075 Eleventh Aspen Emphysema Conference, U. S. Department of Health, Education, and Aspen, Colorado, Jun 12-15, 1968, Welfare, Public Health Service. Current Research in Chronic Respiratory CURRENT RESEARCH IN CHRoNIC OBSTRUCTIVE Disease. U. S. Department of Health, LUNG DISEASE. Tenth Aspen Emphysema Education, and Welfare, Public Health Conference. Aspen, Colorado, Jun 7-10, Service, Washington, D.C., Public Health 1967.U. S. Department of Health, Service Publication Ho. 1879, 1969, Education, and Welfare, Public Health pd. 287-95. Service, Washington, D.C., Public Health Service } ublication No. 1787, 1968, 531 pp. D 12071 Caldwell, E. J. and Fry, D. L. PULMONARY MECHANICS IN THE RABBIT. D 12076 In: Proceedings of the Eleventh Aspen Kilburn, K. H. Emphysema Conference, Aspen, Colorado, CLEARANCE FROM ALVEOLI TO THE CILIARY Jun 12-15, 1968, Current Research in ESCALATOR: IMPLICATIONS FOR PULMONARY Chronic Respiratory Disease. U. S. DISEASES. In: Proceedings of the Tenth Department of Health, Education, and Aspen Emphysema Conference, Aspen, Welfare, Public Health Service, Colorado, Jun 7-10, 1967, Current Re- Washington, D.C., Public Health search in Chronic Obstructive Lung Service Publication No. 1879, 1969, Disease. U. S. Department of Health, PP. 307 -20.

192

19 le D 12076 (continued) D 12084 Education, and Welfare, Public Health Moolten, S. E. Service, Washington. D.C., Public PULMONARY LYMPHATICS IN RELATION TO Health Service Publ_aation No. 1787, PULMONARY CLEARANCE, INTERSTITIAL 1968, pp. 3-25. FLUID AND THE PATHOGENESIS OF EMPHYSEMA. In: Proceedings of the Tenth Aspen Emphysema Conference, Aspen, Colorado, D 12077 Jun 7-10, 1967, Current Research in Laurenzi, G. A., Yin, S., Collins, B., Chronic Obstructive Lung Disease. AndGuaeneri, J. U. S. Department of Health, Education, MUCUS FLOW IN THE MAMMALIAN TRACHEA. and Welfare, Public Health Service, InProceedings of the Tenth Aspen Washington, D.C., Public Health Service Emphysema Conference, Aspen, Colorado, Publication No. 1787, 1968, pp. 191-221. Jun 7-10, 1967, Current Research In Chronic Obstructive Lung Disease. U. S. Department of Health, Education, D 12085 and Welfare, Public Health Service, Said, S. I. Washington, D.C., P.blio Health Service VASOACTIVE SUBSTANCES IN THE LUNG. Publication No. 170, 1968, pp. 27-40. Ina Proceedings of the Tenth Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in D 12078 Chronic Obstructive Lung Disease. Herzog, H., Keller, R., Maurer, M., U. S. Department of Health, Eduation, Baumann, H. R., and Nadjafi, A. and Welfare, Public Health Service, THE DISTRIBUTION OF BRONCHIAL RESISTANCE Washington, D.C., Public Health Service IN OBSTRUCTIVE PULMONARY DISEASE AND IN Publication No. 1787, 1968, pp. 223-8. DOGS WITH ARTIFICIALLY INDUCED TRACHEAL COLLAPSE. In: Proceedings of the Tenth Aspen Emphysema Conference, Aspen, D 12C86 Colorado, Jun 7-20, 1967, Current Re- Read, J., Lee, J. H., and Pain, M. C. F. search in Ch:nnic Obstructive Lung TWO GROUPS OF SUBJECTS WITH OBSTRUCTIVE Disease. U. S. Department of Health, LUNG DISEASE, DEFINED BY PULMONARY Education, and Welfare, Public Health VASCULAR REACTIVITY. InProceedings of Service, Washington, D.C., Public Health the Tenth Aspen Emphysema Conference, Service Publication No. 1787, 1968, pp. Aspen, Colorado, Jun 7-10, 1967, Current 55-91. Research in Chronic Obstructive Lung Disease. U. S. Department of Health, Education, and Welfare, Public Health D 12079 Service, Washington, D.C., P)blic Health Anthonisen, N. R., Bass, H., Oriol, A., Service Publication No. 178i, 1968, pp. Place, R. E. 0., and Dates D. V. 229-39. SOME ASPECTS OF REGIONAL LUNG FUNCTION IN CHRONIC BRONCHITIS. Ina Proceedings of the Tenth Aspen Emphysema Conference, D 12087 Aspen, Colorado,Jun 7-10, 1967, Current Itkin, I. H. Research in Chronic Obstructive Lung BRONCHIAL HYPERSENSITIVITY TO MECHOLYL Disease. U. S. Department of Health, AND HISTAMINE IN ASTHMA SUBJECTS. Education, and Welfare, Public Health In: Proceedings of the Tenth Aspen Service, Washington, D.C., Public F::ith Emphysema Conference, Aspen, Colorado, Service Publication No. 1787, 196'.., Jun 7-10, 1967, Current Research in PP. 103-14. Chronic Obstructive Lung Disease. U. S. Department of Health, Education, and Welfare, Public Health Service, D 12081 Washington, D.C., Public Health Service Penman, R. W. B. and Aetin, T. W. Publication No. 1787, 1968, pp. 243-55. AIRWAY OBSTRUCTION DUE TO HYPDXEMIA IN PATIENTS WITH CHRONIC LUNG DISEASE. In Proceedings of the Tenth Aspen D 12088 Emphysema Conference, Aspen, Colorado, Lyons, H. A., and McFadden, E. R., Jr. Jun 7-10, 1967, Current Research in AIRWAYS RESISTANCE, AIRFLOW AND Chronic Obstructive Lung Disease. INH0410ENEITY DP DISTRIBUTION OF U. S. Department of Health, Education, VENTILATION AS INDEPENDENT ABNORMALITIES and Welfare, Public Health Service, OF BRONCHIAL ASTHMA. InProceedings of Washington, D.C., Public Health Service the Tenth Aspen Emphysema Conference, Publication No. 1787, 1968, pp. 145-59. Aspen, Colorado, Jun 7-10, 1967, Current

193 19'7 D 12088 (continued) D 12093 (continued) Research in Chronic Obstructive Lung Washington, D.C., Public Health Service Disease. U. S. Department of Health, Publication No. 1787, 1968, pp. 339 -55. Education,and Welfare, Public Health Service, Washington, D.C., Public Health Service Publication No. 1787, 1968, PP. D 12094 267-73. Thurlbeck, W. M. INTERNAL SURFACE AREA OF NORMAL AND EMPHYSEMATOUS LUNGS. In: Proceedings D 12090 of the Tenth Aspen Emphysema Conference, Denton, R., Hwang, S. H., Foramen, W. C., Aspen, Colorado, Jun 7-10, 1967, Current Litt, M., and Miller, C. E. Research in Chronic Obstructive Lung VISCOELASTICITY OF MUCUS: ITS ROLE IN Disease. U. S. Department of Health, CILIARY TRANSPORT OF PULMONARY SECRE- Education, and Welfare, Public Health TIONS. In: Proceedings of the Tenth Service, Washington, D.C., Public Health Aspen Emphysema Conference, Aspen, Service Publication No. 1787, 1968, Colorado, Jun 7-10, 1967, Current Re- PP. 379-93. search in Chronic Obstructive Lung Dis- ease. U. S. Department of Health, Edu- cation, and Welfare, Public Health D 12096 Service, Washington, D.C., Public Health Long, D. M. Service Publication No. 1787, 1968, VENTILATION STUDIES WITH SYNTHETIC FLUIDS. pp. 287-307. In: Proceedings of the Tenth Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in D 12091 Chronic Obstructive Lung Disease. Miller, C. E. U. S. Department of Health, Education, AN INVESTIGATION OF THE MOVEMENT OF and Welfare, Public Health Service, NEWTONIAN LIQUIDS INITIATED AND SUSTAINED Washington, D.C., Public Health service BY THE OSCILLATION OF MECHANICAL CILIA. Publication No. 1787, 1968, pp. 425-7. In: Proceedings of the Tenth Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in D 12097 Chronic Obstructive Lung Disease. Pircher, F. J. U. S. Department of Health, Education, LUNG SCANNING IN THE ASSESSMENT OF and Welfare, Public Health Service, OBSTRUCTIVE LUNG DISEASE. In: Proceed- Washington, D.C., Public Health Service ings of the Tenth Aspen Emphysema Con- Publication No. 1787, 1968, pp. 309-21. ference, Aspen, Colorado, Jun 7-10, 1967, Current Research in Chronic Obstructive Lung Disease. U. S. Department of D 12092 Health, Education, and Welfare, Public Ishikawa, S., Fattal, G. A., Zylak, C., Health Service, Washington, D.C., Public Chemieck, R., and Wyatt, J. P. Health Service Publication No. 1787, A POSTMORTEM STUDY OF VISCOELASTIC PROPER- 1968, pp. 429-31. TIES OF LUNG IN EMPHYSEMA (CORRELATION WITH QUANTITATIVE MORPHOMETRY.) In: Proceedings of the Tenth Aspen D 12098 Emphysema Conference, Aspen, Colorado, Hogg, J. C., Macklem, P. T., and Jun 7-10, 1967, Current Research in Thurlbeck, W. M. Chronic Obstructive Lung Disease. THE RESISTANCE OF SMALL AIRWAYS IN U. S. Department of Health, Education, NORMAL AND DISEASED HUMAN LUNGS. and Welfare, Public Health Service, In: Proceedings of the Tenth Aspen Washington, D.C., Public Health Service Emphysema Conference, Aspen, Colorado, Publication No. 1787, 1968, pp. 325-37. Jun 7-10, 1967, Current Research in Chronic Obstructive Lung Disease. U. S. Department of Health, Education, D 12093 and Welfare, Public Health Service, Pratt, P. C., and Thong-Yai, K. Washington, D.C., Public Health Service THE RELATIVE IMPORTANCE OF BRONCHIOLITIS Publication No. 1787, 1968, pp. 433-41. AND EXTENT OF CENTRILOBULAR EMPHYSEMA IN PULMONARY VENTILATORY INTERFERENCE. In Proceedings of the Tenth Aspen D 12099 Emphysema Conference, Aspen, Colorado, Dayman, H. Jun 7-10, 1967, Current Research in THE NORMAL EXPIRATORY SPIROGRAM-- Chronic Obstructive Lung Disease. TECrNIQUE. In: Proceedings of the U. S. Department of Health, Education, Tenth Aspen Emphysema Conference, and Welfare, Public Health Service, Aspen, Colorado, Jun 7-10, 1967, Current

194 D 12099 (continued) D 12132 (continued) Research in Chronic Obstructive Lung older groups the other nonoccupational Disease. U. S. Department of Health, factor - tobacco smoking - is more Education, and Welfare, Public Health significant. (Author Abstract) Service, Waahington, D.C., Public Health Service Publication No. 1787, 1968, pp. 443-7. D 12134 Spevak-Marinkovic, Lj., Mudrinic, P., and Stamenkovic, Z. D 12100 monOEHOA PECTIOPATOPFM OPrAKA KQq nOVOMIAKPEZISIKA. Earle, R. H. and Burrows, B. ETODOOCKANVIVfMAIXICKAWMAMTLA. PROGNOSIS IN CHRONIC OBSTRUCTIVE LUNG OBOLJENJA RESPIRATORNIH ORGANA KOD DISEASE. In: Proceedings of the Tenth POLJOPRIVREDNIKA. Etioloska Aspen Emphysema Conference, Aspen, Epidemioloska Ispitavanja. Colorado, Jun 7-10, 1967, Current (RESPIRATORY DISEASES IN AGRICUL- Research in Chronic Obstructive Lung TURAL WORKERS. Etiological and Diseaee.U. S. Department of Health, Epidemiological Inveetigation.) Education, and Welfare, Public Health Medicinski Pre led 22(1):11-4, 1969, Service, Washington, D.C., Public terto-croft an 8.) Health Service Publication No. 1787, 1968, pp. 453-62. The authors examined 300 agricultural workers to investigate the incidence of respiratory diseases. They found a D 12101 great incidence of chronic bronchitis Talamo, R. C., Austen, K. F., and Allen, and pulmonary emphysema.After analysis J. D. of the etiological factors, the authors FAMILIAL EMPHYSEMA AND ALPHA-1- have the impression that "farmers lung" ANTITRYPSIN DEFICIENCY.--TFT Proceedings disease exists but was not possible to of the Tenth Aspen Emphysema Conference,, prove in the laboratory. The authors Aspen, Colorado, Jun 7-10, 1967, Current present much data concerning the types Research in Chronic Obstructive Lung of respiratory diseases (mainly oc- Dieease. U. S. Department of Health, cupational) that they found. (Author Education, and Welfare, Public Health Abstract) Service, Washington, D.C., Public Health Service Publication No. 1787, 1968, pp. 491-5. D 12162 Stanescu, D. PULMONARY IMPAIRMENT IN COAL MINERS. D 12132 American Review of Respiratory Dieease Potkonjak, V., Pasalic, M., Jablanov, Lj., 170TrITCCJi1 StJ6s. and Djordjevic, V. CTEMMA V3AXEHOCTV (WAN NVUEATMOOPEPE OCCTEWEHTAWAHAjVCAPitrnmscopAymgx64. D 12168 ODNOS STEPENA IZLOZENOST/ FRASINI Preiser, F. M., Donner, M. W., and Van RADNE ATMOSFERE I OSTECEN1A ORGANA Metre, T. E., Jr. DISAJNOG PRIBORA U LIVACA. (CORRELATION COMPARISON OF MIDPLANE, FULL-CHEST BETWEEN THE DEGREE OF EXPOSURE TO AIR- TOMOORAMS, DIFFUSING CAPACITIES, BORNE DUST AND PATHOLOGICAL FINDINGS IN SPUTUM EOSINOPHIL CONTENT, AND OTHER THE RESPIRATORY SYSTEMS OF FOUNDRY PARAMETERS IN PATIENTS WITH ASTHMA WORKERS.) Srpski Arhiv za Celokupno AND EMPHYSEMA. Journal of Allergy Lekaratvo A(9):851787a; 1968, Serbo- 44(3)r154-64, Sep 1969. 7F3rEFFF-(Abs.) A group of foundry workers were ex- D 12203 amined with the aim of ascertaining the Bohlau, V. and Schildwachter, O. correlation between the degree of expo- UNSPEZIFISCHE CHRONISCHE sure to airborne dust and pathological LUNGENERKRANKUNGEN.Diagnostische Und findings in the respiratory system. Therapeutische Aspekte. (CHRONIC Full correlation was found between both NONSPECIFIC LUNG DISEASES.Dia gnlstic and the incidence of fibrosis and chronic Therapeutic Aspects.) Arztliche Praxis bronchitis with the degree of exposure 21(18):1048, Mar 4, 19677137Airri 7677T to airborne duet.Correlation was prominent with incidence of nodular Medical therapy for emphyseua and Cor fibrosis. The degree of exposure to pulmonale is discussed in the light of dust is significant in causing chronic increasing incidence of chronic bronchitis bronchitis in younger workers, but in and bronchial asthma.This group of

195 199 D 12203 (continued) D 12211 (continued) diseases ranks first in number of lost indicate these obstructive diseases. working days, awl second for premature The beat diagnostic tool ie whole retirement for disability. It is known body-plethysmography.As prophylaxis that premature disability retirement for measures it is recommended that cold nonspecific lung diseases costs about symptoms be treated immediately, 300 million DM a year in Germany, and that protection be enacted against some people are forced to retire 7 to 9 dusts and gases, end that Brooking be years before normal retirement age. stopped completely.Treatment con- Increased industrializetion, urbaniza- sists in antibiotic therapy, accompa- tion, and civilization influence the nied by spasmolytic and antlinflam- number of cases. Sanatorium records matory drugs, as needed. Relief for show chronic bronchitis patients are the heart is essential. Prognosis is younger (49-50 years): Chronic never very favorable; 50 percent of bronchitis affects mostly the male, victims die. More recently, due to geriatric population. Juseatz die - the administration of corticoids and covered that the chief cause for early if it is possible to enlist the pa- retirement in 1952 was tuberculosis, and tient's cooperation, life expectancy in 1958 it ranked fourth. Social can be extended considerably. Security records in the Stave of Wurttemberg showed that chrcnic bronchitis diseases increased yearly, D 12216 and chronic brohchitie cases have Geleler, L. doubled since 1964. It ie estimated KLINIK DER CHRONISCHEN BRONCHITIS. that 10 percent of the population (CLINIC OF CHRONIC BRONCHITIS.) suffers from chronic bronchitis, and 5 Praxis 10(3):377-90, 1969, percent from emphysema. Advanced 81-Tirclitbrs7r" emphysema deetroys much lung capillarity and the blood shows increased carbon The incidence, etiology, pathogenesis, dioxide and decreased oxygen levels. and functional effect of chronic Subsequently chronid symptoms of lack bronchitis were discussed. Nicotine of oxygen are seen.The body can only abuse and air pollution were listed partly compensate for the oxygen lack among the external factors which play a and develops blood viscosity. Chronic part in the development of the disorder. Cor pulmonals ie heart stress caused by lungs, especially pressure on the right side of the heart.Ulmer found that 90 D 12231 percent of patients with right-side Wilhelmsen, L., Orha, I., and Tibblin, O. heart Stress suffered from respiratory DECREASE IN VENTILATORY CAPACITY duct obstruction. Modern hygiene in BETWEEN AGES OF 50 AND 54 IN REPRESENTA- working conditions and early diagnoele TIVE SAMPLE OF SWEDISH MEN. British by heart and lung tests are essential. Medical Journal 3(5670):553-67-nrr, Corticoateroid treatment le prescribed together with antibiotics such as row: tetracycline, sulfonamide, and penicillin. Desensitization, D 12253 geronto-therapy, and intensive treatment Mawdeeley-Thomas, L. E. and Healey, P. in special clinics are other THE QUANTITATIVE EVALUATION or EXPERI- prophylactic measures.Early detection MENTAL CHRONIC BRONCHITIS. American of impaired lung function is stressed. Review of Respirator Disease 10012): 231.-737 rug 1969. D 12211 Reif, E. D 12255 DIE OBSTRUKTIVEN ATEMWEGSERKRANKUNGEN. Pugh, D. L. and Page, V. (OBSTRUCTIVE RESPIRATORY TRACT DISEASES.) ACUTE EXACERBATIONS OF CHRONIC BRONCHITIS. Lebonaversieherungsmedizin 21(2)130, Cliff l Trials Journal 6(2)169-80, May 32-4, Mar 1969, airman Ohs.) m.= In a statistical presentation of literature reports, incidences of D 12275 bronchial asthma, bronchitis, pre- Emirgil, C., Sobol, B. J., Norman, J., bronchitis cough, ate., are catego- Moskowitz, S., Ooyal, P., and Wadhwani, B. rized by professional groups, A STUDY OF THE LONO-TERM EFFECT OF teachers, construction workers, and THERAPY IN CHRONIC OBSTRUCTIVE PULMONARY wood workers, The various diagnostic DISEASE. American Journal of Medicine aids which physicians have at their 47(3)i367-T77-331717677--- disposal often fail to adequately

196

2. op D 12293 D 12354 Glaueer, E. M. and Glauser, S. C. Kucewicz, J. THE ROLE OF ACIDOSIS IN THE ETIOLOGY OF PRZEWLEKIE NIESWOISTE CHOROBY UKLADU PULMONARY EMPHYSEMA (34034). ODDECHOWEGO WSROD MIESZKANCOW KRAKOWA. Proceedings of the Societ for VIII. METODA DYSKRYMINACYJNA FISHERA reriffiEltalw;EriOriTey an errEine W ANALIZIE WPLYWU PALENIA TYTONIU NA : - 775I-T9g77 WYSTEPOWANIE OBJAWOW CHOROBOWYCH. (CHRONIC NONSPECIFIC RESPIRATORY DISEASES IN THE CITY OF CRACOW.VIII. D 12319 FISHER'S DISCRIMINATORY TEST IN THE Kendig, E. L., Jr. ANALYSIS OF THE INFLUENCE OF SMOKING ON CHRONIC RESPIRATORY DISEASES IN PREVALANCE OF SYMPTOMS.) Przeglad CHILDREN. Minnesota Medicine Epidemildsslczny 23(2):331-7, 1969, 52(9):1363-7, Sep 1969. Polish (Abs.) A mathematics/ model for prediction of D 12320 the diagnosis on the basis of several Hepper, N. G. G. characteristics, e. g. smoking, in CIGARETTE SMOKING AND CHRONIC chronic respiratory disease is described. RESPIRATORY DISEASE. Minnesota (Author Abstract) Medicine 52(9):1373-5, Sep 71569.

D 12366 D 12321 Concours Medical. El-Sewefy, A. Z. CIGARETTE: LA FIBROSE PULMONAIRE PULMONARY FUNCTION TESTS IN A AUSSI. (CIGARETTES: PULMONARY SHEFFIELD STEEL WORKS. Journal FIBROSIS ALSO.) Concours Medical of the E tian Medical rTgEneTtion 91(25) :5317, Jun 2'1, 1969, rare

ST(IT7.1 : -82, 1968. (Abs.

Investigation of 2,825 adults by D 12339 M. Weiss of Philadelphia was reported. Morton, A. Radiographic signs of diffuse pulmonary POSTOPERATIVE HYPDXAEMIA. Medical fibrosis were evident in 40 of the Journal of Australia 2(7):3Tr427-- subjects. The incidence was more rurrs, 1V619 elevated in men than in women, it increased with age and more rapidly in men than women. The fibrosis was 12353 associated with respiratory sympi:oms Smetanin, E. Ye. and with ventilatory anomalies entirely 113MENEFLIA EnNTENIA OPrAHHOU KYPTY1161 typical of chronic obstructive disease VISPOONAJVHAX 0E1Kmxx ttAxEu nP0 of the lung. A relationship was TPAHIUMIJCEHTAJWHIMIfH44H-HVTRIIMPI- found to exist between the number of METKIWWLA N N-NOTNOWN-METWINOWWW. cigarettes smoked and the patients IZMENENIYA EPITELIYA OROANNOY KUL,TURY difficulties. Tho author explained EMBRIONAMNYKH LEGKIKH MYSHEY PRI these observations by postulating TRANSPLATSENTARNOM WEDENII N-NITHOZODI- that cigarette smoking was the common METILAMINA I N-NITROZO N-METILMOCHEVINY. denominator of diffuse pulmonary (THE EPITHELIAL TISSUE CHANGES IN ORGAN fibrosis as evidenced in these forty CULTURE OF MICE LUNGS IN TRANSPLACENTAL cases and chronic obstructive disease INJECTION OF DIMETHYLNITROSOAMINE (DMNA) of the lung. AND NITROSOMETHYLUREA.Vo roe Onkologii 15(8)148-53, 19 , ussian tAbs.) D 12367 Pariente, R. The results of transplacental action BRONCHITES CHRONIQUES. (CHRONIC of DMNA and NMU on the embryonic lung BRONCHITIS.) Revue de Medecine 10 tissue of mice under conditions of its (16):963, 965,Yr7=8, 971, 973-4, organ cultivation are described. In 977, Jun 1969, French (Abs.) these experiments 621 explants were investigated during different periods of The difficulties involved in time up to 35 days.An evident defining "chronic bronchitis" were stimulation of the epithelial tissue described. The report then dealt growth was demonstrated. It was ex- with anatomical lesions and modifi- Pressed in multiple focal--diffuse cations in chronic bronchitis, factors proliferates resembling adenomatous favoring its development, clinical growths. (Author Abstract) signs, acute respiratory insufficiency

197 2 ot D 12367 (continued) D 12434 (continued) in the patients, differential diagnosis allergic-and infectious allergic and therapy. Factors which favor the (bacterial) forme. psycho - allergic development of chronic bronchitis asthma cauaed by psychic stress is include smoking, air pollution, relatively rare.Tobacco is a alcoholism, occupational and climatic pronounced irritant to the epithelium conditions, infection and personal of the hyperergic reacting mucous factors such as age and genetic and organs. The acetylcholine teat metabolic defects. (always positive here) can dietinguish between both main forma of bronchial asthma from the psychogenic respiratory D 12390 disturbances with aathmoid aymptomatology Klein, R. C., Salvaggio, J. E., and In the opinion of the editor, primary Kundur, V. O. tobacco allergy of the respiratory THE RESPONSE OF PATIENTS WITH "IDIO- tract mucoaa has not yet been demon- PATHIC" OBSTRUCTIVE PULMONARY DISEASE strated. AND wALLEROIC" OBSTRUCTIVE BRONCHITIS TO PREDNISONE. Annals of Internal Medicine 71(4)Or1 =87-0ErT777--- D gggawa, N. JIKKENTEKI MUSE' HAIKISHU NO DENSHI D 12406 KENRICIOOMOTENI IMMO (ELECTRON Densen, P. M., Jones, E. W., Bass, H. E., MICROSCOPIC STUDY CO THE ACUTE Breuer, J., and Reed, E. STAGE OF EXPERIMENTAL PULMONARY A SURVEY OF RESPIRATORY DISEASE AMONO EMPHYSEMA.) Nichidai Igeku Zaaahi NEW YORK CITY POSTAL AND TRANSITWORK- 28(7):765-73, Jul 14g9, Japsin7W-- ERS.2. Ventilatory Function Teat (Abe.) Results.gnvironmental Research 2 (4):277-96, Jul 4969. Ultrastructural changes were observed in the acute stage of experimental pulmonary emphysema of albino rata D 12414 induced by the method of tracheal Wightman, J. A. K. ligation. Morphological alerations A PROSPECTIVE SURVEY OF THE INCIDENCE in the alveolar septa shoved four OF POSTOPERATIVE PULMONARY COMPLICA- different patterns which were TIONS. British Journal of Surgery evidenced by characteristic changes 65(2)s85-91, Veb 1968. in each type. Type I, with the alveolar portions containing only the blood capillaries between the D 12434 covering epithelial layers, and BruschkeO. (Editor). type II, containing the interstitlum FRAGEKISTEN. ASTHMOID BRONCHITIS. besides the capillaries, were easily (QUESTION BOX.ASTHMOID BRONCHITIS.) stretched without destruction or dis- Deutsche Gesundheitswesen 24(31)en.p. appearance of the capillary vessels. 773171969, German (Abs.) Type III, with the division of the blood capillaries missing between the This is a reply to an inquirer who double layers of the alveolar epithelia, had noted that several of his patients and typeIV,composed only of a single with asthmoid bronchitis had suffered epithelium, were weak against extension intensification of their symptoms upon and easily torn off. These results entering a smoke -laden room. He show .hat the fenestration of the wished to know whether among these alveolar aepta in emphyeemic lungs patients there was a considerable occurs in the capillary meshes of psychic superimposition, What con- the aepta and the capillary vessels centrations of tobacco smoke could themselves are not primarily involved. cause such difficulties, and whether The hietogeneaie of alveoli concerned there was a possibility of en allergy in pulmonary emphysema is discussed. to tobacco smoke in the region of the trachea, bronchi and nasal mucoaa. The editor stated that bronchial asthma is D 12441 primarily allergy-calmed and the Waardenburg, H. A. J. result of clinical manifestation of the MALADIES DES FOUMONS CHEZ LE VIEILLARD. bronchiole triad; spasm, edema, and (LUNG DISEASES IN THE AGED.)Medicine dyacrinlam or hypertriniem as a et Eyglone 26(646)t1305-10, Nov 13, consequence of antigen-antibody re- IT6-8-,--Yiitich (Abs.) actions. One distinguishea between the two most frequent forms, nonbacterial

198 D 12441 (continued) D 12503(continued light smokers. Heavy smokers also The article describes how senile manifested fewer subjective symptoms than anatomical and physiological changes light smokers. It was assumed that there in the respiratory apparatus lead to was some selection in the heavy smokers increased vulnerability to nonspecific who had especially good constitutions and infections. The diagnosis and treat- who experienced fewer symptoms or chose ment of chronic nonspecific respiratory to ignore them.The dangers of smoking disorders remains very important in were discussed. view of their frequent tendency to become worse. Tuberculosis of the respiratory apparatus, although de- D 12522 creasing in frequency in the general Reid, L. population, actually occurs relatively BRONCHIAL MUCUS PRODUCTION IN HEALTH AND more often among the aged. The results DISEASE. In: Liebow, A. A. and Smith, D. of conservative treatment are favor- E. (Editors). The Lung. International able. Malignant tumors of the respi- Academy of Pathology Monograph. ratory apparatus are still increasing in Baltimore, Md., The Williams and Wilkins frequency, especially among males. Co., 1968, pp. 87-108. General therapeutic directives are given. D 12525 Gough, J. D 12487 THE PATHOGENESIS OF EMPHYSEMA. In: Burrows, B. and Kettel, L. J. Liebow, A. A. and Smith, D. E. (Editors). IMPORTANT CONSIDERATIONS IN EMPHYSEMA - The Lung. International Academy of CHRONIC BRONCHITIS SYNDROME.Geriatrics Pathology Monograph. Baltimore, Md., 24(11)172-82, Nov 1969. The Williams and Wilkins Co., 1968, pp 109-33.

D 12489 Hayes, J. A. and Summerell, J. M. D 12539 EMPHYSEMA IN A NON-INDUSTRIALIZED TROPI- Lepine, C. and Myre, M. CAL ISLAND. Thorax 24(5):623-5, L'EMPHYSEME PULMONAIRE. CONFRONTATIONS SeP 1969. =Null= ET PHYSIOLOONUES, AVEC UNE REFERENCE SPECIALE A L'USAGE DE LA CIGARETTE. (PULMONARY EMPHYSEMA. D 12503 CLINICAL AND PHYSIOLOGICAL COMPARISON Blohmke, M., Depner, R., Oruntzig, A., WITH SPECIAL REFERENCE TO THE USAGE OF Koschorreck, B., and Stelzer, O. CIGARETTES.) UiMedicale du canal UBER UNTERSCHIEDE IN DER HERZ-LUMEN- 98(11)i1853-8, Nov ov IT /7 177inZE (Abs. FUNKTION UND BEFINDLICHXEIT BEI MANNERN MIT VERSCHIEDENEN RAUCHGEWOHNHEITEN. Forty-one emphysematous patients (ON DIFFERENCES IN THE HEART-AND LUNG admitted to Nopital du Sacre-Coeur of FUNCTION AND THEIR PRESENCE IN MEN OF Cartierville were investigated for DIFFERENT SMOKING HABITS.) Zeitschrift lung function disturbances and for fur Praventivmedizin 14(4 ;235-42, correlation which might exist between 3111-Aug 1969, German (Abe.) clinical symptoms and functional troubles and smoking habits. It is An epidemiological investigation of suggested that respiratory symptoms 1,039 men, consisting of manual and and functional troubles related to nonmanual workers and officials, between bronchial inflammation and obstruction the ages of 40 and 59 years, was carried increase with the number of cigarettes cut concerning the heart and lung function smoked. This preliminary work indicates of smokers and nonsmokers and heavy and a need for further and more specific light smokers. Smokers were generally investigation. (Author Abstract) slimmer than nonsmokers, had lower blood pressure values, and had more sustained performance capacity (ergometer measure- D 12543 ment). Light smokers were slightly McKenzie, H. I., Glick, M., and slimmer than heavy smokers and had lower Outhred, K. O. cholesterol values. Other differences in CHRONIC BRONCHITIS IN COAL MINERS: physiological measurements between light ANTE-MORTETOST-MORTEM COMPARISONS. and heavy smokers were not observed. Lung Thorax 24(5 :527-35, Sep 1969. function of smokers however was below that of nonsmokers. Heavy smokers had fewer absences (and of shorter duration) than

199 203 D 12688 D 12797 (continued) Bouhuys, A., Schilling, R. S. F., and Federation for Clinical Research, van de Woesti5ne, K. P. Atlantic City, New Jersey, May 4-5, CIGARETTE SMOKING, OCCUPATIONAL DUST 1968, Clinical Research 16(2)2377, Apr EXPOSURE, AND VENTILATORY CAPACITY. 1968. Archived of Environmental Health 19(61:7937, Dec 1969. D 12805 Boudik, F., Teichman, V., Novak, K., D 12689 and Jensovsky, J. HePper, N. G., Hyatt, R. E, and Fowler, VYSKYT VLEKLE BRONCHITIDY MEZI we S. VENT:OP/Mg OBYVATELSTVEM. (INCIDENCE DETECTION OF CHRONIC OBSTRUCTIVE LUNG OF CHRONIC BRONCHTIS IN A RURAL DISEASE. Archives of Environmental POPULATION.) VnitIrni Lekarstvi Health 19(6):806-157-Dec 1969. 15(8):736-44, Aug 1969, Czech (Abs.) In 2 regions of northeastern D 12691 Bohemia (Ceske Lips, Semily) the prev- Finklea, J. F., Sandifer, S. H., and alence of chronic bronchitis by Smith, D. D. epidemiological method was studied. CIGARETTE SMOKING AND EPIDEMIC INFLUENZA. 3298 persons (men and women) in American Journal of Epidemiology the age of 30-64 and 15-67 respectively 90(5)1390:9-70 1159. have been examined which represents 76.98 percent of all selected persons in the limited regions chosen. A D 12703 modified British questionnaire for Albert, R. E., Lippmann, M., Spiegelman, J., obtaining factual information has been Strehlow, C., Briscoe, W., Wolfson, P., and used, the answers being interpreted by Nelson, N.. doctors. In the maJority of the THE CLEARANCE OP RADIOACTIVE PARTICLES examineea a simple epirometric examina- FROM THE HUMAN LUNG. Inhaled Particles tion was used (FEV1.0 and FVC, maximal and Vapours II. Proceedings of an expiratory velocity - PEF) and a International Symposium organized by the radiophotogrem in the postero-anterior British Occupational Hygiene Society. position of the 7X7 cm size was performed. Cambridge, Sep 28-Oct 1, 1965. Pergamon The results have been computed in an IBM Press, Oxford and New York, 1966, pp 361- machine. Chronic bronchitis, defined as 78. "a chronic cough and phlegm lasting for at least two of the subsequent years", was found in the group of men in the D 12722 age of 40-64 years in 24.78 percent, in Scarpelli, E. M. women of the same age in 7.06 percent. PULMONARY SURFACTANTS AND THEIR ROLE IN Chronic bronchitis was significantly LUNG DISEASE. Advances in Pediatrics more frequent in cigarette smokers than 162177-210, 1969. in nonsmokers and also in persons after Pneumonia and in persons with small Pleural adhesions as found by X-ray D 12756 examination. (Author Abstract) MeNicol, M. W. CHRONIC BRONCHITIS. Prescribers' Journal 9(4)i90 -7, Oct 1969. D 12825 de Petra, V., Rossi, A., Cecchetti, E., and Maino, R. D 12759 STUDIO CIINICO-STATISTICO DI 2Q6 CASI DI Journal of the American Medical Associa- ASCESSO POIXONARE PR/MITIVO. (CLINICAL- tion. STATISTICAL STUDY OF 206 CASESOF CIGARETTE SMOKING MAY CAUSE SMALL PRIMARY PULMONARY A:BOERS.) Resew& HEARING LOSS. Journal of the American Clinico-Scientifica 45(6)1183-1, Jun Medical Aesociat[on e10Tro7TI845, Dec 1969, Italian (ne.) 8, 1969. Analyses of 206 cases of primary Pulmonary abscess, examined over a 21- D 12797 year period (1945-1965), are presented. Williams, J. B. and Anderson, W. H. Percentage distributions of incidence ACUTE EFFECTS OF CIGARETTE SMOKE ON were made by year, season, age, occupa- DISTRIBUTION OF PULMONARY PERFUSION. tion, predispoaing causes (including Abstract of paper presented at the smoking), symptomatology, extent of fever, National Meeting of the American cavity site, complications, and therapy.

200 204 3

D 12825 (continued) D 12846 (continued) Pulmonary abscess was found to occur in therapy. Patients need strict and more men than in women, probably because intensive medical supervision, and of the male's greater abuse of smoking associated illness, including chronic and alcohol, mu well as hie greater expo- alcoholism, must be treated at the sure to inclement weather. The major same time. (Author Abstract) finding of this investigation was the strong decrease in the number of patien bedridden with pulmonary abeceaa.The introduction of antibiotic therapy was cited as the moat important factor in See alsoB 10450, B 11133, B 11480, B 11627, this decline. Use of antibiotics has U-16849, C 11357, C 11874, C 12265, been found to reduce postoperative E 11458, E 12062, F 10317, F 10458 bronchopulmonary complications, notably reduce the duration of hospital stays for patients affected by the disease, and to promote complete clinical recovery.

D 12840 U.S. Department of Health, Education, and Welfare, Public Health Service and Sherman, M. REAPIRATOHY TRACT IN HEALTH AND DISEASE.A Review of Research Grants Supported by the National Heart Institute 1949 to 1968. U.S. Department of Health, Education, and Welfare, National Institutes of Health, Public Health Service. National Heart Institute, Extramural Programa, Bethesda, Maryland, Aug 1969, 574 pp.

D 12846 Braun, P. URSACHEN UND AUSMASS DER CHRONTEITAT DER TUBERKULOSE. (CAUSE AND EXTENT OF THE CHRONICITY OF TUBERCULOSIS.) In: Langzeitprobleme Innerer Krankheiten in Diagnostik and Therapie. Basel, Switzerland and New York, New York, S. Karger, 1969, pp. 15-34, German (Abs.)

Chemotherapy cannot prevent relapses and the development of chronic tuberculosis. The reasons for these failures are Primarily to be sought in inadequate or incorrect treatment.The patient's personality and the doctor's overoptimistic aesessment of the situation are the main causes. Many social misfits and alcoholics are to be found among tuberculoaie patients. Associated diseases such as diabetes mellitus, pneumoconiosis, gastric disorders, abuse of alcohol and tobacco, and the resistance of tubercle bacilli to the first-line antibiotics Prevent optimum treatment of tuberculosis. A special form of chronic tuberculosis is that in the elderly. It occurs almost enlusively as a result of reactivation of old cavities. Chronic tuberculosis can be reduced or prevented if every fresh case of tuberculosis is cured by intensive combined

201 205 SECTION E. CARDIOVASCULAR DISEASES

E 10190 E 10196 Medecine et Hygiene. Konishi, M., Yamagu,Ali, Y., Koike, S., A PROPOS DE LA FUMEE DE CIGARETTES, Ishigawa, S., and Honda, T. DE LA MALADIE CORONAIRE ET DE MASSHO JUNKAN NI OYOBOSU KITSUEN NO L'HYPOTHESE OENETIQUE. (CIGARETTE EIKYO. (EFFECT OF SMOKING ON THE SMOKE, CORONARY DISEASE AND THE PERIPHERAL CIRCULATION.) Showa ffakkai GENETIC HYPOTHESIS.)Medecine Zasshi 27(:3):1027-9, Dec 1.9777 et H iene 26(834):866, Aug 15, 1968, Japanese (Abs.) French A s.) The effect of smoking one cigarette Several theories concerning the on the temperature of the body extremities relationship between smoking and and on the peripheral blood circulation coronary disease were reviewed. of human subjects was determined. The Several authors believed that the experimental subjects were 12 healthy male association could be explained by the university students, age 22-26 years, none fact (1) that smokers were constitu- of whom had smoked for at least 2 years tionally different from nonsmokers previous to the test. The subjects while and (2) that smokers were more often smoking lay face up in a room maintained of the pre-coronary type than non- at a temperature of 24-26°C. Four of the smokers. Research on twins has subjects puffed lightly at the cigarette, furnished evidence that in six smoked normally and two inhaled monozygous twins with different deeply. The average time of smoking was smoking habits, coronary disease was 5 mins. 10 secs.Body temperature was not more frequent in the smokers than measured by thermistors and blood circula- in the nonsmokers. Smokers appeared tion by strain-gauge pneumatic to be more emotional, anxious and plethysmography.Measurements were presented more psychosomatic symptoms recorded every minute during Molting and than nonsmokers. The author's own every 2, minutes after smoking.The research indicated that the psy- results showed that smoking lowered both chobiological differences were of the quantity of blood circulation and the considerable importance. Another temperature of the extremities. There was study of the author's on the same an increase in the tension of the blood population, compared the differences vessels, the pulse rate and the resistance between individuals chose parents to blood circulation. As regards the had suffered from coronary disorders. method of smoking, the changes were more From this it appeared that anxiety pronounced in the order: puffing lightly, was an excellent factor of discrimina- normal smoking, and deep inhalation. tion between smokers and nonsmokers respectively. and between those whose parents had suffered from coronary disorders and those whose parents were unaffected. E 10204 The number of cigarettes smoked per Blohmke, M., Gruntzig, A., and Schaefer, day played no role in this differentia- H. tion. A separate study has compared DIE ERGEBNISSE DER HEIDEIBERGER HERZ- patients who had suffered coronary KREISLAUFSTUDIE IM SPIEGEL INTERNATIONALER attacks as to whether they ZAHLEN. (RESULTS OF THE HEIDELBERG HEART identified themselves with the AND CIRCULATION STUDIES IN THE LIGHT OF mother or the father. One study INTERNATIONAL FIGURES.) found differences In personality Bundesgesundheitsblatt 11(4):49-52, 2eb between patients who had suffered 19a, German (Absj a myocardial infarct without symptoms and those who had experienced pain One thousand and thirty-nine and another study compared patients Heidelberg males, aged 40-59 years were who had died of a diagnosed coronary compared with populations of 7 other disorder and those who had died with- countries. The comparisons are presented out such diagnosis.The differences in 5 tables entitled: (1) Participation suggest that there are two types of rate, number of investigated individuals, coronary disease, one linked with and percentage distribution, arranged an active metabolic disorder and according to age groups; (2) prevalence another due to senescence. Anxiety rate of pain or feeling of pressure, appears to be the common denominator angina pectoris, and suspicion of between the smoking habit and myocardial infarct; (3) average values coronary disease.

202 No E 10204 (continued) E 10250 for body size and weight and their Medical Journal of Australia. standard deviation (all age groups); SOCIAL STATUS AND CORONARY HEART (4) average value and standard deviation DISEASE. Medical Journal of of blood pressure and serum cholesterol Australia 2(15):63g217atT2, 1968. level in 2 age groups; and (5) percentage distribution of the smoker category and the number of cigarettes smoked daily. E 10257 On the basis of the data it could be Boyle, E. Jr., Morales, I. B., Nichaman, assumed that in the Federal Republic in a M. Z., Talbert, C. R., Jr., and Watkins, so-called healthy i.e. work-capable R. S. population in the 5th and 6th decade, SERUM BETA LIPOPROTEINS AND CHOLESTEROL 10.8 percent have an existing coronary IN ADULT MEN. RELATIONSHIPS TO SMOKING, disease. AGE, AND BODY WEIGHT. Geriatrics 23(12): 102-11, Dec 1968.

E 10213 Kannel, W. B., Castelli, W. P., And E 10261 McNamara, P. M. Jenkins, C. D., Rosenman, R. H., and CIGARETTE SMOKING AND RISK OF CORONARY Zyzandski, S. J. HEART DISEASE. EPIDEMIOLOGIC CLUES TO CIGARETTE SMOKING: ITS RELATIONSHIP TO PATHOGENESIS.THE FRAMINGHAM STUDY. In: CORONARY HEART DISEASE AND RELATED RISK Wynder, E. L. and Hoffmann, D. (Editors). FACTORS IN THE WESTERN COLLABORATIVE Toward A Less Harmful Cigarette. U. S. GROUP STUDY. Circulation 38(6)11140-55, Department of Health, Education, and Dec 1968. Welfare, Public Service, National Cancer Institute Monograph No. 28, Jun 1968, PP. 9-20. E 10262 Sackett, D. L., Epid, M. 3., Gibson, R. W., Bross, I. D. J., and Pickren, J. W. E 10217 RELATION BETWEEN AORTIC ATHEROSCLEROSIS Doyle, J. T. AND THE USE OF CIGARETTES AND ALCOHOL. IMPORTANCE OF DOSE RESPONSE IN TERMS OF (AN AUTOPSY STUDY) New En land Journal TOTAL CIGARETTE SYDKE, "TAR," AND of Medicine 279(26) :T1T3 -20, Dcc68. NICOTINE: CARDIOVASCULAR SYSTEM. In: Wynder, E. L. and Hoffmann, D. (Editors). Toward A Less Harmful Cigarette. U. S. E 10263 Department of Health, Education, and Nutrition Reviews. Welfare, Public Health Service, THE GEOGRAPHIC PATHOLOGY OF National Cancer Institute Monograph ATHEROSCLEROSIS. dUtrition Reviews No. 28, Jun 1968, pp. 43-6. 26(11)1327-30, Nov 1968.

E 10218 E 10266 Murphy, E. A. and Mustard, J. F. Connecticut Medicine. SMOKING AND THROMBOSIS. In: Winder, TO PREVENT HEART DISEASE AND DEATH FROM E. L. and Hoffmann, D. (Editors). MYOCARDIAL INFARCTION. Connecticut Toward A Less Harmful Cigarette. U. S. Medicine 32(11):789-91, Nov 1968. Department of Health, Education, and Welfare, Public Health Service, National Cancer Institute Monograph No. 28, E 10271 Jun 1968, pp. 47-55. Medical Letter. EXERCISE AND CORONARY HEART DISEASE. Medical Letter 10(23, Issue 257):93-4, E 10243 1968. Meade, T. W. THE EPIDEMIOLOGY OF ISCHAEMIC HEART DISEASE.Transactions the Society of E 1028C Occupational Medicine 18(431T27 -S4, Carothers, T. E., Mallow, J. E., and Oct 19687- Stark, F. M. DEATHS FROM CORONARY HEART DISEASE IN PERSONS UNDER THE AGE OF 55. South E 10248 Dakota Journal of Medicine 2(377-8, Elliott, R. and Thyst11, R. Nov 146-67-- A NOTE ON SMOKING AND HEART RATE. PszchophysiologY 5(3)1280-3, Nov 1918.

203 2.01 E Icom E 10319 (continued) Kassir, J. T. Cardioan iolo ica 16(8):660-8, Aug 1968, CHOLESTEROL AND ITS RELATIONSHIP TO ca an vice. HEART DISEASE. Journal of the Facult of Medicine BaghdalIC(1Z)7=9- , Eleven cases of paroxysmal lein:VF-111"8. tachyarrhythmia caused by atrial flutter-fibrillation without clinical symptcms of organic cardiopathy are E 10289 described. The opinion that these crises Fisher, G. R. (which exceptionally may occur for very ASSOCIATED CLINICAL SOCIETIES. Delaware long periods) represent a particular Medical Journal 40(5):364-5, Novi07-- chronologically anticipated phase of permanent total arrhythmia is given.The etiopathogenesis of these crises, recog- E 10301 nizing two periods: the former, of Gifford, R. W., Jr. functional nature, and the latter of MANAGEMENT OF ESSENTIAL HYPERTENSION AND organic nature, formed with harmful ITS COMPLICATIONS. In: Brest, A. N. and elements of the atrial myocardium is Moyer, J. H., Editors. Cardiovascular discussed. Alcoholism and nicotinism Disorders. Philadelphia, Pa., F. A. which may play a role in causing function- Davis Company, 1968, pp. 945-56. al disturbances were not specifically discussed.

E 10304 Likoff, W. E 10322 MANAGEMENT OF CORONARY ATHEROSCaROSIS Ferrucci, M. and Perini, G. AND ITS COMPLICATIONS. In: BrAtt, A. N. CORRELAZIONI TRA ALCUNI VALORI and Moyer, J. H., Editors. Cardiovascu- ANIROPOMETRICI ED EMATOCHIMICI IN UN lar Disorders. Philadelphia, Pa., F. A. ORUPPO DI RECLUTE FERRARESI. Davis Company, 1958, pp. 689-704. (CORRELATIONS OF SEVERAL ANTHROPOMETRIC AND HEMOCHEMICAL VALUES IN A G3OUP OF FERRARESE RECRUITS.)Annali di Medicine E 10305 Navale 73(4):339-50, 7Unner9337----- Coffman, J. D. Trialih (Abs.) EFFECT OF PROPRANOLOL ON BLOOD PRESSURE AND SKIN BLOOD FLOW DURING CIGARETTE The Authors have carried out some SMOKING. Jourral of Clinical anthropometric and hemochemical re- PharmacolegrEN3-tEW 7731717FIT-of New searches, in a group of 360 recruits some Druz! 9(1)739=M-M=FiE77617 evaluations of the clinical symptomatology and tne habit of smoking of the subjects was also made. They have evaluated the E 10306 average values and variants of total cho- Mulcahy, R., Hickey, N., and Maurer, B. lesterol, beta/alpha cholesterol ratio, CORONARY HEART DISEASE.A STUDY OF RISK beta/alpha lipoproteina ratio, turbidime- FACTORS IN 400 PATIENTS UNDER 60 YEARS. try (Phosfotungstic acid test), Kunkel Geriatrics 24(1):106-14, Jan 1969. phenol test, total lipids. As far as blood cholesterol is concerned, the obtained data are a confirmation of those E 10308 obt.ined in preldous experiences carried Gifford, R. W., Jr. out on male subjects of the same age. A DISEASES OF THE AORTA AND THS PERIPHERAL statistical study on the connections of ARTERIES.CHRONIC OCCLUSIVE ARTERIAL the various hemochemical data demonstrated DISEASE OF THE EXTREMITIES. In Brest, a significant correlation of nearly eve.' A. N. &NJ Moyer, J. H., Editors. one of them with the others. Significant, Cardiovascular Disorders. Philadelphia, too, were the reciprocal correlations of Pa., P. A. Davis Company, 1969, the antropometric indexes (scelic and pp. 1017-57. baric indexes, real/physiologic weight's ratio) while lees significant were the correlations between anthropometric and E 10319 hemochemical indexes. According to the Capaldi, E., Oiovanelli, E., and Sgarbi, M. evaluation of 'risk" toward atherosclero- LA FIBRILLAZ1ONE ED IL FLUTTER sis, based upon some hemochemical and PAROZSISTICI IN ,,!:OETTI PRIVI DI SEONI anthropometric date, the Authors infer CONCIAMATI DI LA,,TOPATIA ORGANICA. from their actual experiences, that even (FIBRILLATION AND PAROXYSMAL FLUTTER IN amongst young and apparently healthy SUBJECTS WITHOUT C1SAR SYMPTOMS OF people it is possible to detect some sub- ORGANIC CARDIOPATHY.)Minerva jects showing a trend to atherosclerosis. (Author Abbtract)

204 goR E 10327 E 10369 (continued) De Luca, F., Plancone, R. M., D'Addetta, time of Circulatory Disease. 0., Cramarossa, L., Andrsoli, M., and Vir inla Medical Monthly 96:13-20, Negri, M. Jan L'INFARTO DEL MIOCARDIO: PROGNOSI IMMEDIATA E TARDIVA SU 214 PAZIENTI. (MYOCARDIAL INFARCTION: SHORT-TERM AND E 10379 LONG-TERM PROGNOSIS IN 214 PATIENTS). Dalderup, L. M., Stockmann, V. A., Rassegna di Fisiopatologia Clinica e Rechsteiner de vos, H., and van der Terapeutica 40(2J:145-59, MIF=r514-1168, Italian (Abs.) SURVEYONj.6m DISEASE IN RELATION TO DIET IN PHYSICALLY ACTIVE Short-term and long-term prognosis 26(5):245 -88, 1965. following coron,TY occlusion has been studied in 214 patients recovered from myocardial infarction from 1956 to 1967. E 10393 The over-all mortality during the acute Librach, G. phase is 23 percent (46 percent of the PREVALENCE OF ISCHEMIC HEART DISEASE deaths occurred during the first week of AMONG ELDERLY YEMENITES AND EUROPEANS, hospital admission). The survival rate RESIDENTS OF HOMES FOR THE AGED IN is 50 percent six years after myocardial ISRAEL. Journal of the American infarction and 33 percent twelve Years Geriatric7-Matl 15(T2):112 -$6, after myocardial in:arction) the Dec 1967. incidence of coronary (28.8 percent) or myocardial insufficiency (14.2 percent) 1.1. the survivors is high. Congestive E 10400 heart failure and recurrent coronary MVIcerjee, A. B. occlusion are the ultimate cause of death PRECOCIOUS ISCHAEMIC HEART DISEASE. in the majority of the patients Journal of the Indian Medical surviving the acute phase. Advanced age, ITE6Eigt7m-5M)12107-TITEgil 1, 1968. female sex, sedentary work, history of myocardial infarction or angina, peripheral vascular disease, hypertension, E 10422 ccr pulmonale, diabetes and obesity are Glazunov, I. S., Aronov, D. M., associated with a bad prognosis. Also Drombian, Y. G., and Krylova, E. A. the presence of shock, arrhythmias, ISCHAEMIC HEART DISEASE AND OCCUPA- heart failure, thromboembolic complica- TION. aor el Vasa 6(4)1274-280, 1964. tions, uremia, leukocytosis, increased sedimentation rate, and high levels of serum enzymes have an unfavorable E 10426 influence on th.: survival during the Marcatili, S., Del Bono. M., and acute phase. The prognosis is not Zucchetto, C. significantly affected by the COMPORTAMENTO DELL'EPITELIO electrocardiographic location of the BRONCHIALE IN ALCUNE BRONCO- infarction; on the contrary Prognostic ENEUMOPATIE CRONICHE. (BEHAVIOR OF significance has the extent of the BRONCHIAL EPITHELIUM IN SOME CHRONIC myocardial infarction. The anti- BRONCHOPULMONARY DISEASES.)Rivista coagulant therapy (during the first 2 di Anatomia Patologica e di oriFUniTa months of hospital admission) reduces the 1(3):50846, Mar 1017, Kilian (Abs.) mortality rate during the acute phase in the patients with unfavourable prognosis; Zie authors refer results of there is no influence on the long-term observations made on a large anatomic prognosis. (Author Abstract) material obtained in surgery of patients with different chronic bronchopneumopaties.The behavior of E 10368 bronchial epithelium has beea Kinoshita, S. an Sato, N. particularly investigated which presents EFFECT OF TOBACCO SMOKING ON THE HEART significant modifications in the ESPECIALLY IN YOUNG ADULTS. es above-related cases of chronic inflamma- Circulation Journal 32(9):126 - , eP tory processes.These modifications have been minutely examined and their effects interpreted. (Author Abstract) E 10369 Wvaerman, A. J. THE EVOLUTION AND CONTROL OF ASCVD. The Management of Patient's Life-

205 204 E 10432 E 10460 Medvedev, V. P. Lifeso, R. M. and Miles, J. T. 0 natet-W 0:134,4ECKGR AKni8HOcni HA PA381414,E ATHEROSCLEROSIS:AN ETIOLOGIC AND ATEADcruEPOU. THERAPEUTIC REVIEW.University of Toronto Medical Journal 16(2):4550, 0 VLIYANII FIZICHESKOY AKTIVNOSTI Dec 1968. NA RAZVITIYE TEROSKLEROZA. (THE INFLUENCE OF PHYSICAL ACTIVITY ON THE DEVELOPMENT OF ATHEROSCLEROSIS.) E 10477 Kardiologila 8(9):48-53, Sep 1968, Diaz, F. V., Cesar, F. P., Alonno, Russian (AFs.) J. L., Esteban, L., Martin, E., and Salazar, J. S. The paper deals with clinico- IS A NEW PHYSIOPATHOLOGIC INTERPRETA- biochemical investigation and ECG TION OF OBSTRUCTIVE DISEASE OF THE recording in two groups of men, aged ARTERIES POSSTBLE?AngiologY 19(11): 30-45 years, without hereditary 633-51, Dec 1968. predisposition in respect to ischemic cardiac disease and metabolic affections, with an approximately E 10484 similar nature of nutrition. The Felton, J. S. first group consisted of 77 mental COLLEGE DEGREES AND HEART DISEASE. workers (scientific workers and Jo al of OccupatIona). Medicine engineers) with restrict physical 2 017-57-5;ETIMT activity, the second group - 34 workers engaged in mild and moderate physical labor. Instances of .iyslipidemia, E 10524 clinical manifestations of cardiac Rose, G. A., Ahmeteli,4., Checcacci, L., ischemic disease and hypertensive F1danza, F., Olazunov, I., de Haas, J., vascular disease, ar well as an Horstmann, P., Kornitzer, M. D., Meloni, excessive body weight in persons of C., Menotti, A., van der Sande, D., de the first group wera more significant. Soto-Hartgrink, M. K., Pisa, Z., and The author explains this by the pro- Thomsen, B. tective influence of moderate physical ISCHAEMIC HEART DISEASE IN MIDDLE- activity in respect to the development AGED MEN. Prevalence Comparisons in of atherosclerosis. (Author Abstract) Europe. Bulletin of the World Health Organization 38(6)7885-95,-7§38.

E 10440 New York Medicine. E 10518 THE ROLE OF THE OCCUPATIONAL Pilgeram, L. O. and Pickart, L. R. PHYSICIAN. New York Medicine 24(4): CONTROL OF FIBRINOGEN BIOSYNTHESIS: 202-3, Apr 1356. THE ROLE OF FREE FATTY ACID. Journal of Atherosclerosis Research e115 -66, 11368. E 10451 Journal of the American Medical Association. E 10526 NEW RESEAMH SPARKS DEBATE ON SMOKING Hammond, E. C. AND HEART DISEASE DEATHS. Journal of FACTORS IN THE ETIOLOGY OF CORONARY the American Medical AssociWITUF- HEART DISEASE, STROKE AND AORTIC WIRT1664-6,TE727,-ITTI7---- ANEURYSM. Presented at a Symposium cn °Coronary Heart Disease: Present Status' Albany, N. Y., Oct 17, 1968, E 10453 25 pp. Mulcahy, R. AETIOLOGICAL FACTORS IN CORONARY HEART DISEASE. Medical Research E 7O537 Council of irelsETTS0707-N-7-31. Spain, D. M., Bradess, V. A., Matero, A., T1T77-- and Tarter, R. SUDDEN DEATH DUE TO CORONARY ATHEROSCLEROTIC HEART DISEASE. E 10457 Age, Smoking Habits, and Recent Charms, B. L. Thrombi. Journal of the American PATHOPHYSIOLOGY OF CARDIAC SYMPTOMS. Medical Association In Brest, A. N. and Moyer, J. H. TT, 1959. (Editors). Cardiovascular Disorders. Philadelphia, Pa., F. A. Davis Company, 1968, pp. 160-76.

206 2W E 10542 E 10603 Denham, R. M. Hellung-Larsen, P., Laursen, T., Kjeldsen, SMOKING AND THE CORONARY CIRCULATION. K., and Astrup, P. GP 39(2):129, Feb 1969. LACTATE DEHYDROGENASE ISOENZYNES OF AORTIC TISSUE IN RABBITS EXPOSED TO CARBON MONOXIDE. Journal of E 10549 Atherosclerosis 8W5elYZE87148-8, 1968. Schirmler, W. and Neff, C. RAWNGEWOHNHEITEN UND HERZINFARKT. (SV4.,KING HABITS AND MYOCARDIAL E 10604 INFARCT.) Allgemeine Therapeutik Siggaard-Andersen, J., Kjeldsen, K., 8:325-30, 1L68, German (Abs.) Petersen, F. B. and Astrup, P. A POSSIBLE CONNECTION BETWEEN CARBON The authors have reviewed the MONOXIDE EXPOSUM, CAPILLARY FITRATION known risk factors of myocardial RATE AND ATHEROSCLEROSIS. (Preliminary infarct and 'owe cited the findings Report) Acta Medica Scandinavica 182(3) of the Framirllam and Albany Studies :397-9, T887. and the connlvrAons of the Terry Report. They have also presented their own 1962-1965 observations on E 10611 503 male infarct patients and 714 Oberwittler, W. controls having no detectable ANMERKUNG ZUR INTERPRETATION DER heart disease. More non-mokers FRAMINGHAM-STDDIE. (CONVENT ON THE and exsmokers were in the control INTERPRETATION OF THE FRAMINGHAM group than among the Infarct STUDY.) Medizinishce Welt 19 45): patients. Heavy cigarette smoking 2478-80, Nov 9, 1968, German (Abs.) was found to play an increasingly important role in the younger age Some deficiencies of the Framingham groups up to the age of 59 years. study were discussed. Analysis of the From that age, differences in the study and its interpretation can be incidence of myocardial infarct made without any knowledge of the were less obvious and past the age statistical considerations. A character- of 70, no differences Were discern- istic example of the study, namely the ible. The relationship of heavy graphs concerning the combination of cigarette smoking to hypertexsion risk factors and the incidence of and cholesteremia and the role of coronary disease, is therefore illus- smoking in blood clotting and thrombus trated. It can be observed that the formation was also discussed.The columns of the familiar graphs of the mechanism of action by which study represent risk indexes for coronary nicotinism leads to myocardial infarct disease. They represent the relationship has not presently been clarified but between observation and expectancy values, the discontinuance of cigarette but give no information concerning the smoking reduces the rick of future number of the afflicted. Also, according myocardial infarct. to the statistics, the risk of suffering a coronary disease doubtless rises with the increasing number of burdening E 10568 factors. On the other hand, closer Engel, R. R., Rodkey, F. L., O'Neal, analysis of the study shows that almost J. D., and Collison, H. A. one-third of the individuals developing RELATIVE AFFINITY OF HUMAN FETAL a coronary disease did not manifest a HEMOGLOBIN FOR CARBON MONOXIDE AND single risk factor, a fact that is highly OXYGEN. Blood 33(0:37-45, Jan 1969. significant in the discussion of the causality of the arteriosclerotic process.

E 10570 Gertler, M. M., White, P. D., Cady: E 10612 L. P., and Whiter, H. H. Fodor, J. T., Glass, L. H., and CORONARY HEART DISEASE. A Prospective Weiner, J. M. Study. American Journal of thq IMMEDIATE EFFECTS OF SMOKING ON Medical 17TEM7ii-r3(7310-98,75ct 1964. HEALTHY YOUNG MEN. Public Health Reports 84(2)1121-6,-1079M---

E 10600 Diament, M. L. and Palmer, K. N. V. E 10619 AN ANALYSIS OF PRE-OPERATIVE PA02 Anjuere: J. IN A GENERAL SURGICAL POPULATION. PEUT-ON PREVOIR L'INFARCTUS Thorax 24(1)1126-8, Jan 1969. MYOCARDIQUE?FACTEURS PREDISPOSANTS.

207 err E 10619 (continued) E 10627 (continued) (CAN ONE FORESEE MYOCARDIAL INFARCT? Two pairs had died as a result of PREDISPOSING FACTORS.) Archives myocardial infarct; the third pair had Medicales diAngers 69(3):151 -8, May- suffered from coronary disease with Jun 1968, French (Abs.) fatal outcome and have been included in the study. All were or had been ciga- One hundred patients with first rette smokers previous to death: (1) myocardial infarct were studied. 55-year-old brothers, both diabetic. both The patients consisted of 53 men heavy smokers, (2) one brother died at average age 64 years) and 47 women 47 years, the other surviving by 10 years; average age 75 years). Thirty-three both had smoked until the death of one 31 men and 2 women) were heavy brother after which the survivor had smokers; average amount of tobacco stopped smoking and drinking; (3) one consumed was 17 grams per day with a brother died at 45 years, the other 15 maximum of 60 grams per day in 2 months later; the surviving brother had patients; all who smoked in excess of stopped smoking 4 years before the 10 grams per day deeply inhaled the other's death. The study demonstrated smoke. The mortality was not influenced the significance of the genetic and by the use of tobacco; 14 percent of environmental factors. the smokers were deceased. The statistical study can describe the individual least likely to develop E 10642 myocardial infarct:the nonmenopausal Eastcott, H. H. G. female; in general, the nonsmoker, BUERGER'S DISEASE REASSESSED. Lancet nonobese and nonhypertensive; one with- 1(7587):200-1, Jan 25, 1969. out familial or personal vascular antecedents; and one having h normal cholesterol level. E 10643 Bassett, D. R., Moellering, R. C., Rosenblatt, G. Greenberg, D., and E 10620 Stokes, J., III. Kinoshita, S., Sato, N. and Mashimo, K. CORONARY HEART DISEASE IN HAWAII. JAKUNEN DANSEI NI OKEL KITSUEN NO Serum Lipids, and Cardiovascular, SHINZO NI OYOBOSU EIKYO, TOKU NI Anthropometric, and Related Findings in SHINJIKU TO NO KANKEI NI TSVITE. Japanese and Hawaiian Men. Journal cf (EFFECT OF SMOKING ON THE HEART OF Chronic Diseases 21(8):565-8377E-1'f69. YOUNG MALES, PARTICULARLY IN RELATION TO THE HEART AXIS.)Naika 22(7): 1455-8, Dec 1968, Japanese (Abs.) E 10648 Adams, C. W. Estimates of the deviation of the PREVENTION BY AGGRESSION. Diseases heart axis were made from the electro- of the Chest 55(2)195-6, Feh 1959. cardiograms of 984 males, none of whose electrocardiograms showed any obvious abnormalities. The male subjects E 10651 comprised 782 smokers and 202 non- Lancet. smokers and ranged in age from 15 to SERUM-URIC-ACID AND CORONARY HEART- 84. Correlations were made of axis DISEASE. Lancet 1(7590) :358, Feb 15, deviation with age and with smoking. 1969. The results show that the tendency to left deviation increases with age and that this tendency occurs 5 years E 10656 earlier in smokers than it does in Krut, L. H. nonsmokers. CURRENT CONCEPTS OF ATHEROGENESIS. British Journal of Clinical Practice k(12):5177:727-pec Mr E 10627 Parade, O. W. E 10680 HERZINFARKT BEI ERBOLEICHEN ZWILLINGEN. Dlin, B. M. (MYOCARDIAL INFARCT IN IDENTICAL THE DOCTOR, HIS EMOTIONS AND HIS HEART. TWINS. (OBERVATIORS AND CONSEWENCES).) Minnesota Medicine 52(2)1351-74, Feb Zeitschrift fur Gerontologie 1(3)1151-5, 1969. May 1968,3erman (Abs.)

Genetic influences have been studied through the analysis of the case histories of 3 pairs of identical male twins.

208 E 10697 E 10729 TjawokinW. W. Sorour, A. H. and El-Sherif, A. A. EXPERIMENTELIE CORONARSKLEROSE DURCH ALOUNGS PROBLEMAS CARDIOVASCULARES. BEWEGUNOSEINSCHRANKUNG BEIM (SEVERAL CARDIOVASCULAR PROBLEMS.) KANINCHEN. (EXPERIMENTAL CORONARY Dia Medico 40(44):1253-5, Jul 1968, SCLEROSIS INDUCED BY IMMOBILIZATION WEnish (Abs.) OF RABBITS). Virchows Arehiv Pathologische Wfari 3f611): Statistics have been presented to 21-45, 1969, German (Abs.) demonstrate the increasing incidence of various types of cardiovascular diseases We report a new method of in Egypt. Several measures have already producing arteriosclerosis with been taken to improve the situation coronary insufficiency in rabbits by including the study and prevention of means of immobilizing them. In our rheumatic fever and its consequences, studies the experimentally induced hypertension and atherosclerosis. An atherosclerosis develops by hyp9dynamles institute of cardiology is being imposed by the reduced muscular established. A hemodynamie unit was activity without overloading with established in 1948 and cardiac surgery exogenous cholesterol. The athero- begun in 1949; the first mitral sclerosis and coronary insufficiency valvulotomy was performed in 1953; a are associated.With variations in rehabilitation center to rheumatic the duration and extent of immobiliza- convalescents was established. A tion, coronary insufficiency alone or tribute was also paid to Prof. M. Ibrahim with atherosclerosis can be produced. for his work in advancing cardiovascular This new method for producing knowledge in Egypt. arteriosclerosis and ischemic cardiac disease has its clinical counterpart. (Author Abstract) E 10737 Maunoury, L. ARTERIOPATHIES OBLITERANTES CHRONIQUES E 10707 DES MEMBRES INFERIEURS. (CHRONIC Hauss, W. H., Junge-Hulsing, G., and OBLITERATING DISEASE OF THE LOWER LIMBS.) Oberwittler, W. Revue de Medecine 9(28) :1809 -23, Dec UBER DIE BEDEUTUNG DER "UNSPEZIFISCHEN 1966, rFeneh (Abs.) MESENCHYMREAKTION" FUR DAS ALTERN. (SIGNIFICANCE OF "NONSPECIFIC The pathology and treatment of the MESENCHYMAL" REACTIONS FOR THE AGED.) different stages of chronic obliterating Zeitschrift fur Gerontologie 1(5):281-8, diseases were reviewed. The etiological Sep 1968, German (Abs.) varieties included diabetic, Buerger's disease, rickettsial, and gouty forms. Speed of extension and tendency of localization of atherosclerosis are responsible for the individually E 10767 different speed of ageing: considerations Santrucek, M. and Vacek, M. on pathogenesis of athersoclerosis KOURENI A ISCHEMICKA CHOROBA meet with the problem of the cause of SRDECNI VE SVETLE EPIDEMIOLOGICKYCH the process of ageing.Rate of STUDII. (SMOKING FROM THE ASPECT severity and frequency of complica- OF EPIDEMIOLOGICAL INVESTIGATION.) tions of atherosclerosis and the speed 3eskoslovenske Zdravotnictvi of the process of ageing are probably 16(2):66-n, 1968, Czech tAbs.) connected with a pathologic increase of metabolism of connective tissue by The effect of smoking on the way of the "nonspecific mesenchymic cardiovascular system was the reaction". (Author Abstract) subject of extensive investigations in man' countries during the past ten years. The acute effect of E 10714 smoking was fairly reliably eluci- Nutrition Reviews. dated experimentally. Epidemiological IDIOPATHIC MYOCARDOPATHY IN CEYLON. investigations attempted to clarify Nutrition Reviews 27(1):9-11, Jan the sequelae of many years of heavy 1969. smoking. An attempt is made to evaluate critically hitherto Assembled facts and probable hypotheses as well as to formulate questions which are still to be solved. The need of

209 are E 10767 (continued) F 10797 multifactorial analysis under various Burch, R. R., Rogers, J. A., Gulotta, C. J., conditions is emphasized. Strong Comer, E. 01B., McCurley, D. R., Rufty, smoking is one of the important causal A. J., Jr., and Baltz, H. J. factors in the development of myo- SYMPOSIUM ON CURRENT MANAGEMENT OP cardial infarction and only this ACUTE MYOCARDIAL INFARCTION. Journal assumption can explain all known of the Louisiana State Medical Society facts. (Author Abstract) 1-ffcr)ti-3, Jan

E 10769 E 10799 Whitaker, W. Bloor, C. M. and 7,eon, A. S. ETIOLOGY OF CORONARY DISEASE. THE GENETIC DETERMINATION OF CORONARY Practitioner 202(1208):207-15, ARTERY PATTERNS: A POSSIBLE FACTOR IN Feb 1969. ATHEROGENESIS. Annals of the New York of ScierFiETT97)78r0-4, Acade,MB. E 10770 Strong, J. P., Eggen, D. A., Newman, W. P., III, and Martinez, E 10804 R. D, Santrucek, M. NATURALLY OCCURRING AND EXPERIMENTAL K OTAZCE UMRTNOSTI NA ARTERIO- ATHEROSCLEROSIS IN PRIMATES.Annals SKLEROTICKOU CHORORU SRDECNI. of the New York Academy of Sciences (MORTALITY DUE TO ARTERIOSCLEROTIC TTPTW187-94, Nov 21, 13587------HEART DISEASE.) Ceskoslovenske Zdravotnictvi 16(5):259-63, 1968, Czech (Abs.-I E 10783 Stamler, J., Berkson, D. M., Levinson, An analysis of statistical data M. J., Mojonnier, L., Epstein, M. B., pertaining to causes of death reveals Hall, Y., Burkey, F., Soyugenc, R., and the rising incidence from arterio- Andelman, S. L. sclerotic heart disease, in particular A LONG -TERM CORONARY PREVENTION in younger age groups. There are EVALUATION PROGRAM. Annals of the New considerable differences between York Academy of Scienc777797)7M different countries. In all countries 377-Nov 21, J.M. the mortality is considerably higher in men. The analysis confirmed that only a multifactorial hypothesis can explain E 10784 the revealed facts. (Author Abstract) Wissler, R. W. and Vesselinovitch, D. EXPERIMENTAL MODELS OF HUMAN ATHEROSCLEROSIS. Annals of the New York E 10810 Academy of Sci ncer1-07277967=a7- Abbas', A. S., Raze, M., Beg, M. A., Nov 21, TT& . and Syed, S. A. CORONARY HEART DISEASE IN PAKISTAN- - SERUM CHOLESTEROL IN HEALTHY ADULTS E 10785 AND PATIENTS WITH CORONARY HEART Raab, W. DISEASE. Journal of the Pakistan PATHOPHYSIOLOGICA1 FUNDAMENTALS OP THE Medical lisTaTirfron 131)T285 -9 ORIGIN AND PREVENTION OF DEGENERATIVE Aug 1968. HEART DISEASE. Annals of the New York Academy of ScienFir1 g6TI)7211-4, Jan 31, TT69. E 10811 Reid, D. D. SMOKING AND THE HEART. Health 5(6): E 10793 176-7, Dec 1968. Benack, R. T. ETIOLOGY OP CONGESTIVE HEART FAILURE IN CLINICAL MEDICINE.Annals of the E 10824 New York Academy of EcieMeinfT(TIT Hart Hansen, J. P. 59440"27 Jan 31, 1169. CORONARY DEATH IN YOUNGER PERSONS. Danish Medical Bulletin 15(10): sams, Dec 2, 1968. E 10795 British Medical Journal. MANAGEMENT OF CORONARY ARTERY DISEASE. British Medical Journal 1(5630i37-8, Taiii7017:

210 214 E 10845 E 10847 (continued) Gsell, O. Georg Thieme Verlag, 1968, pp. 17e-92, TABAKRAUCHEN UND HERZERKRANKUNGEN. Berman (Abs.) (SMOKING AND HEART DISEASES.) In: Schievelbein, H. (Editor). Nikotint The following observations were made Pharmakologie and Toxikologie des concerning the effects of smokingt Tabakrauchea. Stuttgart (Weet Germany), Thromtocyte count did not appear to be Geo:g Thieme Verlag, 1968, pp. 154-70., influenced; aggregating capabilities German (Abs.) appeared to be affected but this may be an artifact resulting from the complex- Prospective and retrospective ities of statistical comparisons; no studies were reported. The studies changes cesulted from the reaction of showed that there was a clear thrombocytes and latex particles and no relationship between smoking and differences were observed between smokers myocardial infarct, very Pronounce: in and nonsmokers; changes in thrombocyte the younger age groups up to 50 years, adhesivenesa appeared to depend on the and still evident in heavy smokers test method employed; throMbooyte life between 51 and 60.The recognition appeared to be shcrtened; inhaling tended of all the factors taking part in the to increase adhesiveness of thrombocytes; development of coronary sclerosis offers no changes were observed in nucleotide or he possibility of avoiding myocardial serotinia content of thrombocytes; fibri- infarct and the coronary dieordrre of nolysla appeared to be little influenced) middle age. thrombus formation time was decreased; and sharp changea in blood clotting could not be confirmed. E 10846 Wahl, Pand Schettler, 0. ARTERIOSKLEROSE UND FETTSTOFFWECHSEL. E 10848 (ARTERIOSCLEROSIS AND PAT METABOLISM.) gess, H. Ins Schievelbein, H. (Editor).Nikotin: RAUCHEN UND ARTERIEL1E DURCHBLUTUNGS- Pharmakologie and Toxikologie &le STORUNGEN CER EXTREMITATEN. (SMOKING labakrauchea. Stuttgart (West Germany), AND ARTERIAL CIRCULATORY DISTURBANCES Georg Thieme Verlag, 1968, pp. 171-7, OF THE EXTREMITIES.) Ins Schievelbein, German (Abs.) H. (Editor). Nikotins Pharmakologie and Toxikologie des Tabakrauchee.Stuttgart !le atheroganic effect of smoking has (West Germany), Georg Thieme Verlag, not been definitely clarified. Athero- 1968, pp. 193-8., German (Abs.) sclerotic attack of the aorta is more marked in smokers.More certain relation- The relationship between smoking ships between smoking and arteriosclerosis and chronic obliterating vascular of the cerebral and peripheral arteries diserses was reviewed. The investiga- are not proved.Epidemiological studies tions cited dealt with intermittent suggest that nicotine has no cumulative claudication, thromboanglitis obliterans, effect on the intima, or in other words, obliterating arteriosclerosis and obliter- on atherogenesis of the coronary arteries. ating vascular diseases. It was con- There is no recognizable difference in the cluded that smoking was only one factor cholesterol levels of smokers and non- in the genesis of obliterating vascular smokers. Triglycerides also do not diseases; six reasons were enumerated in appear to be influenced by smoking. Free support of this view.Almost all of the fatty acid levels rise briefly after authors were of the opinion that absten- smoking but this effect is neither con- tion from smoking was the basis of all sistent or positive. One may conclude treatment for thromboanglitis obliterane that a poeeible relationship exists be- and several expressed the belief that tween smoking and arteriosclerosis but the such abstention resulted in stasis of the effects of smoking on the vascular system disease. Abstention from smoking was are not explainable by its influence on recommended in all forms of obliterating lipid metabolism. anglopethy.RaynaudIs disease and acute inflammatory arterial diseases were also briefly mentioned. E 10847 Murphy, E. A. THROMBOZYTEN, THRCKBOSE UND GERINNUNO. E 10857 (THRCKBOCYTES, THROMBOSES AND CLOTTING.) Schroder, J. Ins Schievelbein, H. (Editor). Nikotint KOHLENMONOXYDGEHALT DES BLUTES BEI Pharmakologie and Toxikologie des RAUCHERN. (CARBON MONOXIDE CONTENT OF Tabakrauches. Stuttgart (West Germany), THE BLOOD IN SMOKERS.) Ins Schievelbein, H. (Editor). Nikotint Pharmakologie

211 E 10857 (continued) E 10888 and Toxikologie des Tabakrauches. Gershon-Cohen, J., Borden, A. G. B., Stuttgart (West Germany), Georg Thieme and Hemel, M. B. Verlag, 1968, pP. 278-84., German (Abs.) THERMOGRAPHY OF EXTREMITIES AFTER SMOKING.British Journal of Radiology The following topics were reviewed: 42(495):189-91,-g§r 1969. Relationship between carbon monoxide and carboxyhemoglobin; absorption and lihera- tion of carbon monoxide; conditions for E 10899 carbon monoxide absorption in smokers; Rosenman, R. H. carbon monoxide content in tobacco smoke PROSPECTIVE EPIDEMIOLOGICAL RECOGNITION and carboxyhemoglobin content in smokers OF THE CANDIDATE FOR ISCHEMIC HEART and nonsmokers; and the carboxyhemoglobin DISEASE. Psychotherapy and Psycho- content in smokers and depth of inhala- somatics 16(4251:1-93-20177968. tion. The carboxyhemoglobin content was invaribly greater in cigarette smokers than in non-or occasional smokers with E 10906 highest values in the inhaling smokers. Graziano, J. L., Olander, G. A., and Lal, R. B. SIGNIFICANCE OF THE PROFUNDA FEMORIS E 10870 ARTERY IN EXTREMITIES WITH MARKED ISCHE- British Medical Journal. MIA. American Surgeon 35(4):229-33, CORONARY DISEASE AND COMPETITIVENESS. Apr 1969. British Medical Journal 1(5635):1-2, 757-1-77-1T07-7- E 10913 Middleton, C. C. E 10874 NATURALLY OCCURRING ATHEROSCLEROSIS IN Stejfa, M., Jr. TURKEYS. Proceedings of the Societ PREDICTIVE SIGNIFICANCE OF RISK FACTORS for Euerimental Bibloa and Medicine IN EXERTIONAL ANGINA 2ECTORIS. TrU(2):638-42, Oeb 1961. caEgoloata 51(0:336-9, 1967.

E 10922 E 10878 Dawber, T. R. and Thomas, H. E., Jr. Chung, C. S., Bassett, O. R., Moellering, PROPHYLAXIS OF CORONARY HEART DISEASE R. C., Jr., Rosenblatt, G., Stokes, J., STROKE, AND PERIPHERAL ATHEROSCLEROSIS. III., and Yoshizaki, H. Annals of the New York Acade of RISK FACTORS FOR CORONARY HEART DISEASE Scfence3-111TAFticre-2): 8=57,, IN HAWAIIAN AND JAPANESE MALES IN Nov 21, 1968. HAWAII. Journal of Medical Genetics 6(1)159-66, Mar iro. E 10943 Tibblin, 0. E 10885 ROKNING OCH HALSA (1)s RISKER FOR Journal of the American Medical KORONARSJUKDOM. (SMOKING AND HEALTH (1): Association. RISKS OF CORONARY DISEASE.) IN RATS, AT LEAST: HYPDXIA + NICOTINE Lakartidningen 65(44)14341-4, Oct 30, HEART LESIONS. Journal of the American 1968, Swedish (Abs.) Medical Association 207(i1)Tr370, Mar 11, 1969. After a review of literature on risk fact7Ts in coronary disease (high cholesterol, hyPertensionhigh E 10886 triglycericks, smoking, physical British Medical Journal. inactivity, and stress), the author's CIGARETTES AND ATHEROMA. British work is presented: Since 1963 at the Medical Journal 1(5642):4667176-22, Sahlgren Hospital a survey has been 1969. conducted on men born in 1913. Of 973 randomly chosen men, 92 percent were studied in 1963. The studies E 10887 concerned cardiovascular disease, with Abramson, D. I. special regard to correlating etiological DIAGNOSIS AND MANAGEMENT OF ARTERIAL factors. In 1967, 90 Percent were DISORDERS OF THE EXTREMITIES. Modern restudied.In 1963, 56 percent smoked Medicine 1103-10, Apr 7, 1969. and 20 percent had stopped smoking. Of 834 men examined in 1967 who had had no earlier symptoms of coronary disease,

212 ad& E 10943 (continued) E 10970 15 had developed heart infarcts and 9 Boyaner, H. O. angina pectoris, with simultaneous INFLUENCE OF ALCOHOL ON CORONARY development of pathological EOGs.The FUNCTION IN RABBITS WITH ATHEROSCLEROSIS 15 infarct cases were all smokers; INDUCED BY CHOLESTEROL.Nature half smoked more than 15 cigarettes a 221(5185):1066-7, Mar 15, 1969. day. In the angina group, 3 out of 9 had never smoked. No cases of sudden death were noted. Since Jaruary 1968 E 10991 a clinical study has been made of all Fox,-S. M. and Paul, O. infarct cases born in 1913 or later. PHYSICAL ACTIVITY AND CORONARY HEART The first 50 patients showed two DISEASE. American Journal of Cardiology interesting things: there was a strong 23(2):298-35678eb 1969. preponderance of men (49 to 1); and all were smokers at the time of the first infarct. E 10992 Bhandari, M. M., Jain, S. R., Chhabra, M. L., and Sepaha, O. C. E 10944 BLOOD FIBRINOLYTIC ACTIVITY IN Heinemann, A. L., Kritsikis, Sp., and MYOCARDIAL INFARCTION. Indian Heart Eitner, S. Jou-nal 20(4):361-8, Oct 1988. ZUR PROBLEMATIK DER DEGENERATIVEN HERZERKRANKUNGEN IM ASPEKT DES ZUSANMENWIRKENS VON DISPOSITION UND E 10993 EXPOSITION. (ON THE PROBLEM OF Shankar, P. S. DEGENERATIVE HEART DISEASES FROM THE CARDIOVASCULAR DISEASE: ITS MORBIDITY VIEWPOINT OF THE INTERACTION OF AND MORTALITY IN NORTHERN MYSORE STATE. DISPOSITION AND EXPOSITION.)Deutsche Indian Heart Journal 20(4):423-31, Oct Gesundheitswesen 23:1766-71,SeD'9 ET 1968. German (Abs:)

The investigation, which was carried E 10996 out on 4,797 electrical and metal workers Acheson, R. M. in 6 Berlin plants, included the effects CORONARY DISEASE AND COMPETITIVENESS. of age and sex, blood pressure, vital British Medical Journal 1(5639):319, capacity, occupational and leisure-time physical activity, occupational status, marital status and tobacco consumption. The findings showed that: morbidity E 10998 increased with advancing agein rather Master, A. M. and Geller', A. J. linear fashion; men became ill more THE EXTENT OF COMPLETELY ASYMPTOMATIC frequently than women; engaging in CORONARY ARTERY DISEASE. (Editorial) leisure-time sport had a favorable American Journal of Oardio/oey 23(2): influence, with athletes suffering least; 1737137-741969. -..elow 3 liters of vital capacity there was 2.4 times as much degenerative heart disease than above 4 liters; hyperten- E 11004 sives fell ill approximately 2.5 times Metropolitan Life Insurance Company as often as normotensive and hypotensives Statistical Bulletin. with approximately the same results for PROGNOSIS IN CORONARY HEART DISEASE systolic and diastolic blood Pressure. AMONG METROPOLITAN EMPLOYEES. The data on tobacco consumption were Metropolitan Life Insurance c_qmpany incomplete (the individuals were merely ITRfftical BUTT-4M 76117.1,-ZWI469. listed as smokers or nonsmokers) but smokers appeared to fall ill more often than nonsmokers. E 11028 Christian, P. INTERDEPEND= VON UM WELT UND PERSON AM E 10959 BEISPIEL DES HERZINFARKTES. Bullok, B. C., Clarkson, T. B., Lehner, (INTERDEPENDENCE OF ENVIRONMENT AND N. D. M., Lofland, H. B., Jr., and St. PERSONALITY IN MYOCARDIAL INFARCT.) Clair, R. W. Psychotherapy and Psychosomatics 16(4-5): ATHERCSOLEROSIS IN CEBUS ALBIFRONS 210-23, 1946, aWmanTAbe.) MONKEYS. III. Clinrarand Fafhologic Studies. Exrimental and Molecular Sociological influences, habits and Pathology 10(1pe)t39-62, Tri5 laT. Personality structure are all decisive for the development of coronary disease. With the aim of elucidating their inter-

213 ad7 E 11028 (continued) E 11042 (continued) relationships, the following six stood or misinterpreted the clinical methodological principles are results obtained from this study on established: risk-increasing behavior twine. Since both twins are genetically (heavy cigarette smoking, abnormal eat- identical, change of environment or ing habits, pathological behavior pat- habits in one twin can be linked to any terns, etc.); 'coronary factora' as disease syndrome shown by only one of shown in psychological tests; Profession- the twins without fear of a genetic al motivation as an increased riski predisposition for any specific disease 'illness behavior'; paychodynamic on the part of the other twin. The aspects. Riek Personality and socio- findings on the study of identical twins cultural background are interrelated. are therefore considered valid and (Author Abstract) should be of interest in the future when determining whether coronary insufficiencies may occur in relation to E 11029 the habit of tobacco smoking. Clinical Hachure, B., Piestrak, J., and Nowak, S. findings and the causal relationship PRZYPADEK ZESPOLU WIENCOWO-MOZOCWEGO. linking smoking to heart disease, such (A CASE OF CORONARY-CEREBRAL SYNDROME.) as angina pectoris, are reviewed on Wiadomosci Lekerekle 21(2912271-4, studies made with British and Norwegian Dec15, 19617-11BIiih (Abs. immigrants, and nativeborn Americans. The authors describe a case of coronary-cerebral syndrome in a 64-year- E 11044 old woman. Simultaneously with the Custovic, F. and Bubanj, D. manifeetations of acute coronary failure BUERGEROVA BOLEST ILI PRESENILNA a transient left-aided hemiparesis ATEROSKLEROZA. (BUERGER'S DISEASE OR developed. After several days hemi- PRESEN/LE ATHEROSCLEROSIS.)LiJecnicki paresis regressed parallelly with die - Vesnik 90(6):585-9, Jun 1968, Serbo-. appearance of the aymptoms of acute Crjoation (Abe.) coronary failure. (Author Abstract). Noeologic aspects of Buerger'a disease are highlighted in this literature review E 11035 of 17 references. Since 1950, many au- Hahn, P. thors have expressed the opinion as to PSYCHOSOMATISCHE ASPEXTE DES INFARKT- whether or not Buerger's disease is a PROFILES. (PSYCHOSOMATIC ASPECTS OF true disease entity. It is definitely a INFARCT P?'..?ILES.1Ilychotherapy and Peripheral vascular disease and is Psychosomatics 16 4-51:2g1:32, 1061: referred to by many authors as thrombo- German (Abs.) angiitis obliterane, a term devised by Buerger. Presumably, the disease was Characteristic features of the known prior to Buerger's time as it was organic and psychological risk factors in described by Jaesche (1865), Lavirier myocardial infarction are Presented and (1866) and Friedlander (1876) under illustrated by a case history. The different names: arterlitie obliterans, psychosomatic aspects can be Been as and endarterlitis obliterans. Fisher interdependent products of various groups termed it cerebral thromboangiitis of factors within the total personality. obliterans.This disease leads to other The case history included conatantly body disturbances and infections contus- increasing physical inactivity, increaee ing the original disease symptoms so much in weight (above 30 kg) and heavy smoking that some physicians believed that (40-60 cigarettes per day) Since 1964. tobacco 'smoking would alleviate or even cure the disease. Oldham referring to the diseaae is famous for the statement: E 11042 You can have your cigarettes or you can CederM, R., Friberg, L., and Landman, T. have legs. You cannot have both. OCH ANGINA PECTORIS--EN REPLIK, Modern diagnoaticians recommend that the

(MOKING(SMOKING AND ANGINA PECTORIS--A REPLY./ term 'Buerger's disease" be deleted from 65(46):4516-7, Nov 13, medical terminology. It is not truly a clinical entity but is composed of symptoms which precede or accompany others, Polemics are presented in reply to such as disturbances of the peripheral Tibblin's (Lakartidningen No. 44 (1968)) circulation in general, leading to refutation of studies by the present peripheral atherosclerosis. authors on heart disease that were conducted on identical twins. It is Poiated out that Tibblin either misunder-

214 aot E 11054 E 11068 Gothman, B. Aetrup, P. EN HJART-KARLKIRURGISK STUDIERESA I USA. BLACKFOOT DISEASE. (BLACKFOOT DISEASE) (A CARDIOVASCULAR STUDY IN THE USA.) Ugeskrift for Lae ear 130(43):1807-15, Svenska Nationalforeningen mot Heart-och Get 24, 19g37 n e (Abs.) tungsfukdomar 63(3):66-62, T3'68, SwedriT (Abs.) A scientific expedition to Taiwan in 1967 is reported in which blackfoot A map shows the A summary report is provided on a disease was surveyed. study-trip made to the United States to locations of highest incidences of this evaluate heart and blood vessel diseases. disease, typical case histories are pro- Representatives were from such institu- vided, and figures illustrate the amputa- tions as: the Thoracic Surgery Depart- tions. Details are also given on the ment of the Cleveland Clinics, the pathological anatomy, etiology and patho- Clinics for Vascular Surgery at Baylor genesis. Etiology can be complicated in University,the Department of Vascular- that the arsenic concentration in the Surgical Clinics of the University of blood and the dissociation curve for the San Francisco, and the 40th Meeting of oxyhemoglobin seem to greatly influence These param- the American Heart Association. Statis- the outbreak of the disease. tics on heart and circulatory diseases eters, in turn, are influenced by external in the United States are given, and factors: the type of water the person medical opinion is surveyed as to when drinks (artesian well, or river water), surgery of the coronary vessels is the caloric intake, and whether or not he indicated, and when surgery of the smokes. Synergism of the causative agents central and peripheral vessels should be may also occur. For example, tobacco done. Some techniques are described plants are often sprayed with arsenicals briefly and indications for using them as pesticides. In Such cases, the smoker are given.From these abstracted not only ingests tobacco, but also the meeting papers, it may be generalized tobacco decomposition products, and when that not all revascularization operations smoking also ingests certain amounts of today are "workable", although clinical, arsenic. The rather high incidence of physiological and biochemical tests periphers1 arteriosclerusis in Taiwan must on such patients show that some benefit be explained on the basis of such syner- is derived. In 75 percent of the cases, gistic effects. Cases reported in pain as,,ociated with heart disease may earlier literature from other parts of be lessened. One paper discusses the the world (Silesia and the vicinity of relationship between blood cholesterol Cordoba, Argentina) can bo similarly assay and heavy cigarette smoking. explained.

E 1.055 E 11088 Tibblin, G. Frankel, E. KOMMENTAR TILL LN SVENSK TVILLING- CORONARY DISEASE AND PERSONALITY. UNDERSOKNING. (COMMENT ON RESEARCH British Medical Journal 1(5640):382-3, ON TWINS IN SWEDEN).Lakartidningen Feb 8, 19117 65(47i:4654-5, Nov 20, 1968, Swedish (Abs. E 11092 Experimental results and conclusions Bucher, H. W. and Stucki, P. derived from an investigation of the NOREPINEPHRINE-INDUCED RISE IN link between the incidence of angina CIRCULATING BLOOD PLATELETS AND FREE pectoris and cigarette smoking, in Sweden, FATTY ACIDS IN ARTERIAL AND VENOUS are disputed by Friberg, Cederlof, and BLOOD OF PATIENTS WITH ISCHAEMIC HEART Lundman (Lakartidningen No. 44, year DISEASE AND CONTROLS. Helvetica Medics 1968). The present author attacks the Acta 34(6):503-9, 1968. definition of coronary disease, casts doubt on the diagnostic value of involving twnns in such a testing program, and E 11093 calls for stricter delineation between British Medical Journal. the concepts of smokers and nonsmokers. MYOCARDIAL INFARCTION AND PEPTIC ULCER. The percentages and types of tobacco British Medical Journal 1(5638)1237, smoked should also be taken into consid- 717121;; rejsr-- eration in any investigation of this type. Regarding statistics and electrocardiographic findings, the case is E 11094 mentioned of 90 from a group of 181 men Douglas, A. S. showing a false positive diagnosis PREVENTION AND TREATMENT OF THROMBOSIS. involving heart disease.

213 E 11094 (continued) E 11223 (continued) Journal of the Royal College of Sweden, 1968, pp. 18, 28, 30-4, 1,E,n-ribireir7 TM:171-51, Jan 1V39. 5/, 45.

E 11110 E 11241 Connecticut Medicine. Fitzgerald, P. GENETIC FACTORS IN CORONARY HEART ARTERIAL DISEASE AND TOBACCO. DISEASE. Connecticut Medicine Anesthesia and Analgesia 53(3):16b-4, Mar 1969. 48(3):12-777Rey-Jun 1969.

E 11120 E 11250 Hoff, H. E. and Gottlob, R. Leb, G., Derntl, F., Goldachlager, STUDIES ON THE PATHOGENESIS OF ATHER- N., Cowan, C., and Bing, R. J. OSCLEROSIS WITH EXPERIMENTAL MODEL SYS- DETERMINATION OF EFFECTIVE AND TEMS. I. An Electron Microscopy Study TOTAL CORONARY BLOOD FLOW USING of the Effect of Artificial Pat-Emulsion Rb-84. American Journal of the Injections into the Lumen of Doubly - Medical 1717;Fices 257:203-T7,-0r Ligated rabbit Carotid Arteries.Virchowa Archiv fir Pathol /echeAnatomic s l0 3eun nische MedinE ( ): E 11253 McDonald, L, Gent, Q.and McDonald, A. CORONARY CARE UNITS. Practitioner 202 E 11154 (1208)1238-50, Feb Ayres, S. M., Mueller, H. S., Gregory, J. J., Olannelli, S., Jr., and Penny, J. L. SYSTEMIC AND MYOCARDIAL HERODYNAMIC E 11254 RESPONSES TO RELATIVELY SMALL CONCENTR- Nagle, R. E. ATIONS OF CARBOXYHEMOOLABIN (COHB). PROGNOSIS OF CORONARY HEART DISEASE. Archives of Environmental Health8(4): Practitioner 202(1208)1251-8, Feb 1959. 694109, XiOr 1969. E 11259 E 11160 Sigurjonsson, J. Wainwright, J. UNBAR-RURAL DIFFERENCES IN MORTALITY FROM CARDIOVASCULAR DISEASE IN THE ASIATIC ISOMERIC HEART DISEASE. Americ Journal : - (INDIAN) POPULATION OF DURBAN. goulh of the Medical Sciences 2 African Medical Journal 43(6):136=,- FiE77-136T7--- E 11276 E 11214 Modzelewski, A. and Malec, A. Jornal do Medico. ZACHOWANIE SIE NIEKTORYCH LIPIDOW WE KRWI U PALACZY. (PATTERNS OF CERTAIN 0 TABACO PROVOCA MATS DOENCAS CARDIACAS Wiadomoaoi DO gps CANCROS DO PULMAO. (TOBACCO BLOODLIPIDS IN SMOKES.) CAUSES MODE HEART DISEASES THAN LUNG Lekarskie 22(3):229-33, Feb 1,1969, CANCERS.) Joal do Medico 67(1354)147, ToIiih (Abs.) Jan 4, 1969, Por uguese (Abs.) The authors determined blood levels of The remarks of Dr. Otto (!sell at an cholesterol, beta - lipoproteins and free fatty acids in 102 cigarette smokers with internatimal conference of doctors in The Heidelberc were reported. Dr Gsell also a history of many years of smoking. added that atatletics of different control group comprised20nonsmokers It was found, that in countries and orgarizations showed that matched for age. heart disease in individuals below the the subgroup of subjects smoking up to 10 age of 50 years was more frequent in cigarettes daily the increase of the smokers, as was also true in the 50 to serum level of cholesterol, beta- 70 year group. lipoproteins and free fatty acids was not statistically significant in comparison with the controls. A statistically sig- E 11223 nificant difference was observed only in the subgroup of smokers smoking over 1) Carlson, L. and Lindstedt, S, A. cigarettes daily.Particularly marked THESTOCKHOLMPROSPECTIVE STUDY 1. lipics The Initial Values for Plalma Lipids. differences in the level of the Acta Medici: Scandinavica Suppl. No. were found in comparison with the control 493, Almqv!et & Wiksell, Stockholm, group of subjects aged over 50 years.

216 E 11276 (continued) E 11286 The duration of smoking also had an effect Choi, Y. Y. cn the serum lipid level. After 5 years EFFECT OF NICOTINE UPON CHOLESTEROL- of smoking a statistically significant INDUCED ATHEROSLCEROSIS pi RABBITS. rise of cholesterol, beta-lipoproteins New Medica% Journal 10(7):49-57, 1967, and free fatty acids was observed. (Author Abstract). It is known for some time that smoking is an important factor in E 11278 the etiology and the progression of Ferrante, O. and Zacche, E. thromboangiitis obliterans (Buerger's CARCINOMA A CELLJLB GIGANTI DEL POLMONE. disease) though its mechanism is not Aspetti Clinico- Radiologici. (GIANT clear. The present investigation is CELL CARCINOMA OF THE LUNG.Clinicoradio- undertaken to, study the effect of logical Aspects.) Quaderni di Radiologia nicotine upon cholesterol- induced 33(6)1653-67, Nov-DE.77TM Milan (Abs.) atherosclerosis on the assumption that nicotine might enhance atheroma The authors, after stressing the formation. 64 Albino rabbits were utmost rarity of this histological divided into 8 groups and treated variety of the primary carcinoma of the with cholesterol and nicotine in lung defined as by *giant cells", go on different concentrations. The result to describe the two cases that happened revealed that the gross atheroma under their observation. Taking in formation in the aorta was markedly consideration the data supplied by reduced in the groups treated with literature which were wholly similar to cholesterol together with nicotine and theirs, they find it very interesting to the degree of inhibition was parellel point out some of the aspects of these to the dose of nicotine administered. neoplasia, namely the riotous clinic But the changes of vascular wall due evolution associated with the swift to the administration of nicotine alone growing of the neoformation, always by consisted of necrosis, degeneration of clean and circumscribed outlines. elastic fibers, cystic changes and Though not claiming to arrive at any calcification of the media of the conclusions, owing to the limited number aorta and endothelial hyperplasia in of cases, the authors deem that the small arteries.Contrary to an frequent periphericity of carcinomata by original assumption that nicotine *giant cella" so contrasting with a might have enhancing effect on rapidly developing clinic-radiologic cholesterol-induced atherosclerosis tableau is an element to be kept well in in rabbits, the result showed an mind for an eventual differential diagno- inhibiting effect of nicotine. sis. (Author Abstract). E 11303 B 11283 Journal of the American Medical Associa- Scoppetta, V. tion. SUL OONTENUTO DI OSSIDO DI CARBONIO NEL THE A/R WE BREATHE. Journal of the SAME CIRCOLANTE DI OESTANTI FUMATRICI. American Medical AssonEET3.) 751ff77 (CARBON MONOXIDE CONTENT IN THE BLOOD 353;776F rr7-r9n. CIRCULATING IN PREGNANT SMOKERS.) Archivio di Ostetricia e Oinecologia 73(31,360=75, may-Jun MC, Italian E 11314 (Abs.) Fox, W. A XOMEOPATH LOOKS AT CORONARY DISEASE. Carbon monoxide (CO) concentrations Journal of the American Institute of in the venous blood of 46 pregnant air-tfi- rm. ,2-3 ) :6-97-741E71F-Nri. women were found to be higher in smokers than in nonsmokers. In 19 samples of maternal and funicular venous blood, obtained at the moment E 11316 of delivery, CO concentrations were Barnes, J. R. approximately the &WOO, while CO EARLY DETECTION OP ATHEROSCLEROTIC concentrations per 100 gr. of haemo- HEART DISEASE. New York AAA Journal globin were lower in the samples of of Medicine 69(37TTC=T; Feb -T,71777- fetal blood than in those of maternal blood. (Author Abstract)

217 E 11338 E 11355 (continued) Softer, A. of time, can be an important factor in ONLY ONE-THIRD REACH THE HOSPITAL. the pathogenesis of coronary insuffi- (Editorial)Dieeases of the Chest ciency.Stress, with repeated adrenergic 55(4):272-3, stimulus, which may safely be considered more frequent and intense than in earlier historical periods appears to be the E 11345 prime factor in the increase in the Muller-Dietz, H. incidence of coronary disease.The SOVIET CARDIOLOOICAL RESEARCH AND smoking habit, sedentary :Ire, and a diet PRACTICE.Review of Soviet Medical high in caloric and lipid content must be Sciences 5():12-8;-1§1957-- considered important links in causing the increase in morbidity and mortality by coronary insufficiency. E 11354 Jouve, A.Courbier, R., and Lavaurs, G. LES ARTERIOPATHIES DES MEMBRES. (ARTERIO- E 11358 pATHTES OF THE LIMBS.) Concours Medical Attall, J.-R. 91(7)11360, 1363, 1365-6, 1169, Pitt-157 HYPERTENSION ARTERIELLE. (ARTERIAL 1969, French (Abs.) HYPERTENSION.) Gazette Medicale de France 76(8):16237.137-Mia, 15, 1969, The text and illustrations concerning rep----Ene (Abs.) the diagnosis and the medical and surgical treatment of the arterial diseases had Diagnosis, etiology, and therapy of been presented on French television on arterial hypertension were outlined. January 7, 1964. The majority of the Therapeutic ensures included suppression afflicted individuals were in the second of excitant' (tobacco, alcohol, coffee). half-century of their existence with the greatest incidence in the 50 to 52-year- old-segment, but c.e-fourth of the E 11359 patients were below the age of fifty. Nature. Various factors contribute to the develop- TAHAC, POUMON ET COEUR. {TOBACCO, ment of the disorder, of which the most LUNG AND HEART.) Natu 3405):26, prominent is tobacco. All statistics are Jan 1969, French (Ati . in agreement on this point and there are practically no cases of arterlopathiee The risk of contracting lung cancer below the age of forty in which there had is 20 times greater for heavy cigarette not been heavy consumption of tobacco. smokers than for nonsmokers. The risk Twenty-eight percent of the cases were of coronary thrombosis is only doubled discovered in the first stage of the by excessive smoking, but it le still disorder, that is, before the initiation the primary cause of death in the more of intermittent claudication. highly developed countries, according to a recent WHO bulletin.Of 100 excess deaths due to various causes, 16 can be E 11355 attributed to lung cancer and 50 to heart Ferreira, I. J., Anderiz, M., La Figuera, disease. Mortality is accelerated by E., and Cebollaot, J. familial, occupational and social ten- FACTORES ADRENERGICOS EN LA PATOGENIA sions. Ths more an individual is exposed DE LA INSUFICIENC/A CCRONARIA.(ADRENER- to such tensions, the more he smokes, and GIC FACTORS IN THE pATHCOENESIS OF CORO- as a consequences, thromboses and other NARY INSUFFICIENCY.)Revista Es nola de cardiac processee are accelerated. Cardiologia 21(3):321-37MT 1988; Spanish TIbs.) E 11362 The recent literature on the action Plante, M. M. of catecholemines as possible factors AWED CLINIQUE DE L' HYPERTENSION of coronary insufficiency has been re- ARTERIELLE A L'HOTEL-DIED DE MONTREAL. viewed. It was postulated that such hor- (CLINICAL APPROACH TO ARTERIAL HYPERTEN- mones can lead to coronary insufficiency SION AT THE HOTEL -D/EU DE MONTREAL.) by three mechanisms, (1) functional Ilan Medical 220(45)s1167-70, 1173-6, mechanisms, (2) production of hyper- -,116 1191-8, Nov 10, 1968, lipemia, and (3)determination of French (Abe.) hypercoagulability. The possible action of tobacco on the genesis of coronary Procedures for the examination and insufficiency was also discussed. therapy of arterial hypertension at the Nicotine increases the liberation of hospital are outlined.Smoking is catecholamines from lipoid deposits. This formally condemmed because of its action repeated frequently, in the course cardiovascular effects.

116 E 11370 E 11374 (continued) Semeraro, S., Cremonini, O. P., Oarbini, O. C., Facchini, 0., and Civiero, 0. After the smoke of a strong cigarette STUDIO COMPARATIVO SU ALCUNE VftRIAZIONI there have been observed hemocoagulative SFIOMICHE ED EMOCOAOULATIVE INDOTTE DAL changes, expressed especially by an in- FUMO DI SIOARETTA IN SOOOETTI NORMALI E crease in the "r" and "k" tinea and in VASOPATICI.NOTA PRIMA: OLI EFFETTI an increase in the maximum TEO amplitude SFIUMICI. (COMPARATIVE STUDY CN SOME ae will ae in a lengthening of the time of SPHYOMIC AND HEMOCOAGULATIVE VARIATIONS euglobulinic fibrinolysis.These changes INDUCED BY CIGARETTE SMOKE IN NORMAL were more evident in a group of 15 AND VAWPATHIC PATIENTS REPORT I. arteriopathic subjects than in a group of THE SPHYOMIC EFFECTS.) Bollettino della 15 controls. Insignificant were the Societe, Italians di Cardiolcsia 13(67: variations in the Decalcification time, 668-75, 1966, Itarran (Abs.1 the partial thromboplastin time, the pro- thrombin time, and in the fibrinogenesda. The authors proposed a comparative The hemocoagulative and fibrinolytic study between vascular and hemocoagulative changes do not always coincide with the effects of tobacco smoke. The present major degrees of the aphypic reactivity, note deals with some ephygmic modifica- as shown by the oscillographic, digital tions. The experiment made on 150 normal plethysmographic and craniocerebral and Arteriopathic subjects, in whom the rheographic studies. (Author Abstract) effects of the smoke of one cigarette was thoroughly examined on the craniocerebral rheogram, the digital photo- E 11378 plethysmogram, the cardiac rate, the maxi- Avtandilov, O. 0., ArifkhanoVa, S. I. and mum and minimum humeral pressure, the Bekker, O. M. maximum digital pressure and the humero - digital pressor gradient. On three groups 802PACTlik 0C060110CTY1Rk3EPRY91ATEPOCKIEPO3A8 of reactive subjects the same teat of 00061-tMOTABAAAAPTEPtikblialallIMWMFAIBEKA. smoke was reported after novocainization VOZRASTNYVEOSOBENNOSTIRAZVITIYA in the ganglion atellatum on one side, ATEROSKLEROEA V OSNOVNYKH OTDELAKH after premedication with t sympatholytic ARTERIAL'NOY SISTEMY CHELOVEKA. (A0E- drug (dihydroergotamine) end after treat- SPECIFIC FEATURES PECULIAR TO THE ment with adrenergic blockade respectively; DEVELOPMENT OF ATHEROSCLEROSIS IN MAJOR The results obtained demonstrated that SEGMENTS OF THE HUNAN ARTZRIAL SYSTEM.) tobacco smoke exerts a vascapastic action Vestnik Akedemli Meditsinskikh Neuk on the brain and in a larger measure on P4(Eit4E-52, 1969, Russian I-April-- the arterial digital level with an increase in peripheral resistances (decrease Statistical processing of the data in the humero-digital pressor gradient). ensuing rrom planimetric evaluation of The vascular reactivity to smoke seems to atherosclerosis in 2287 anatomic complex be stronger in vaaopathic patients, in preparations of longitudinally opened younger subjects and in women.Discordant aortas, common iliac arteries, major results were obtained in non-smokers. trunk arteries of the heart, abdominal Likewise a protective action on vascular organs and the brain base furnisLed a smoke effects was observed by dihydro- background for comparative assessment of ergotamine and novocainization of the qualitative and quantitative peculiar- ganglion stellatum as far as the corre- ities attending age-qualified develop- sponding upper limb le concerned.An ment of atherosclerosis in the main parts equal protective action of bsnodaine was of the human arterial system.Subject to not observed. (Author Abstract) the moat intensive and gross lesion are aorta and iliac arteries, with coronary arteriaa of the heart coming next, the E 11374 third and fourth places being taken Cremonini, O. P. Semeraro, S., Facchini, 0., respectively by the arteries of the Oarbini, O. C., Collcngo, O., and Spagna, brain base, major trunk arteries of the I. abdominal organs. (Author Abstract) STUDIO COMPARATIVC SU ALCUNE VANIAZIONI SFIOMICHE ED EMOCOAOULATIVE INDOTTE DAL FUMO DI SIOARETTA IN SOOGETTI NORMALI E E 11379 VASOPATICZ. NOTA SECONDA: OLI EFFETTI Brown, H., Sellwood, R. A., Harrison, C. V. EMOCOAOULATIV/. (COMPARATIVE STUDY ON and Martin, P. SOME SPHYOMIC AND HEMOCOAOULATIVE VARIA- THROMBOANOIITIS OBLITIRANS. British TIONS BY win:ANS OF CIGARETTE SMOKE IN Journal of Surgery 56(1):59-637717r1969. NORMAL AND VA93PATHIC SUBJECTS REPORT II. THE HEMOCOAGULATIVE EFFECTS.) Bollettino della Societe Italians di CardiBTEATE---- 11TUTA76 -ITr; 1968, ItaTien (Abe.;

219 E 11381 E 11430 Wu, C-C., Huan6, T-S., and Hsu, 0-I. Berenson, G. S. PREVENTION OF EXPERIMENTAL ATHEROSCLEROSIS MYOCARDIAL INFARCTION. Rocky Mountain WITH WRIDINOLCARBAMATE. American Heart Medical Journal 66(4):41-7, Apr 1969. Journal 77(5):657-67, May 1969.

E 11432 E 11382 Marriott, H. J. L. Shapiro, S., Weinblatt, E., Frank, C. W., PREMATURE BEATS (EXTRASYSTOLES). and Sager, R. V. Current Therapy :168-70, 1969. INCIDENCE OF CORONARY HEART DISEASE IN A POPULATION INSURED FOR MEDICAL CARE (HIP). Myocardial Infarction, Angina Pectoris, E 11439 and Possible Myocardial Infarction. Van Dellen, T. R. American Journal of Public Health and the DOES BUERGER'S EXIST? (EDITORIAL) Nation's MiTaW5T(67TW17,75.17-t-Tr: Illinois Medical Iournal 135(4):404-5, 1-101, Sun 1969. Apr 1969.

E 11401 E 11441 Duncan, C. H. and Best, M. M. Eliot, R. S. and Bratt, O. AN APPROACH TO THE PREVENTION OF THE PARADOX OF MYOCARDIAL ISCHEMIA AND CORONARY ARTERY DISEASE. Journal of NECROSIS IN YOUNG WOMEN WITH NORMAL the Kentucky Medical AssocrEFE56674): CORONARY ARTERIOGRAMS. American 266-7, 309, Apr 1969. Journal of Cardiology_ 237633-47-May 1969.

E 11408 E 11442 Kane, W. C. and Aronson, S. M. Logue, B. CEREBROVASCUIAR DISEASE IN AN AUTOPSY. ANGINA PECTORIS. Current Therapy : POPULATION. I. Influence of Age, Ethnic 158-62, 1969. Background, Sex, and Cardiomegaly upon Frequency of Cerebral Hemorrhage. Archives of Neurology 20(5):514-26, E 11443 FTY-rgg§.-- Lindsay, A. E. WHAT'S THE RHYTHM? Rocky Mountain Medical Iournal 66(4):66, Apr 1969. E 11411 Crawford, M. D. and Crawford, T. LEAD CONTENT OF BONES IN A SOFT AND A E 11457 HARD WATER AREA. Lancet 1(7597)3699-701, Wilson, R. B., Martin, T. M., and Apr 5, 1969. Hartroft, W. S. FAILURE OF INSULIN THERAPY TO PREVENT CARDIOVASCULAR LESIONS IN DIABETIC E 11413 RATS FED AN ATHEROGENIC DIET. Diabetes Kallichurum, S. 18(4):225-31, Apr 1969. DEATHS CAUSED BY HEART FAILURE IN THE BANTU IN DURBAN.South Africian Medical Iournal 43(8) :214 -7 Feb 22, 1969. E 11458 Suppa, G. and Mezzasalma, O. LA VALUTAZIONE DEL RISCHIO OPERATORIO E 11414 NEI PAZIENTI AFFETTI DA MALATTIE Hoffmann, H. DELL'APPARATO CARDIOVASCOLARE E STRESS AT THE WHEEL.World Health RESPIRATORIO. (ASSESSMENT OP SURGICAL :5-10, Feb 1969. RISKS IN PATIENTS WITH CARDIOVASCULAR AND RESPIRATORY DISEASES.) Minerva Chirurgksa 2415):243-54, Mar 15;-1-969, E 11417 Italian (Abs. Fukushima, H., Toki, K., AND Nakatani, H. THE EFFECT OF N-(a-METHYLBENZYL) The difference between "assessment of LINOLEAMIDE ON EXPERIMENTAL ATHEROSCLEROSIS the cardiorespiratory function" and IN RABBITS. Journal of Atherosclerosis 'assessment of the specific risk of Research 9(1)TS7=Ti7 /in-Feb 1969. surgery" is defined and a systematic pattern for the evaluation of these factors is presented. Five 'classes of risk" are proposed, although they cannot be sharply defined. Assessment of the specific hazard of surgery has a certain

220 aa.4 E 11458 (continued) E 11466 (continued) unavoidable margin of error which can be cigarette smoking, diabetes mellitus, reduced by careful clinical and functional overweight), EKG at rest (leads I, II, evaluation and by close collaboration III, aVR, aVL, aVF, V1-V6, evaluated between the cardiologist and general according to the Minnesoc..-Code), (4) physician on the one hand and the surgical EKG during'stepwise increased ergometer- team on the other. (Author Abstract) work. The following conclusions are drawn: (a) Severe coronary artery disease can be excluded if history, EKG at rest E 11463 and EKG during ergometer-work are normal. Giornale di Medicine Militare. (b) In patients with a normal EKG DUBBIO IL RAPPORTO TRA TABACCO E at rest and no history of angina pectoris CORONAROPATIE. (DOUBTS THE RELATION- EKG-signs for coronary insufficiency can SHIP BETWEEN TOBACCO AND CORONARY be provoked using orgometer-work. DISEASE.) Giornale di Medicine (c) Severe stenotic or occluding coronary Militare 118(4):582,-7111-Aug 1968, artery-disease must be expected if the TERTITH-(Abs.) exercise-EKG shows typical ischemic ST- segment-depression. (Author Abstract) A study of epidemiological data had led C. C. Seltzer to doubt that the use of tobacco could explain the increased E 11506 mortality from coronary diseases.Angina Damon, A., Damon, S. T., Harpending, H. C., Pectoris probably could have no relation- and Kennel, W. B. ship to the use of tobacco and only in PREDICTING CORONARY HEART DISEASE FROM slightly more than one-half of the cases BODY MEASUREMENTS OF FRAMINGHAM MALES. could there have been a relationship Journal of Chronic Diseases 21(11-12): between myocardial infarct and tobacco. 781-80,7p11-1767: The more recent data does not permit the establishment of a relationship between the number of cigarettes smoked 11537 and the frequency of coronary complications Longhino, C., Poetiglione, G., and the same uncertainty exists if we consider Fortis, P. A. the duration of the smoking habits and LA NOSTRA ESPERIENZA CON LA the effects of its renunciation. Finally, GANGLIECTOMIA LOMBARE NEL TRATTAMENTO according to Seltzer, from the epidemi- DELLE ARTERIOPATIE OBLITERANTI ological viewpoint, evidence of a relation- CRONICHE PERIFERICHE DEGLI ARTI ship between tobacco and coronary disease INFERIORI. (OUR EXPERIENCE WITH 18 not greeter now than in 1964. LUMBAR GANGLIECTOMY IN THE TREATMENT OF CHRONIC PERIPHERAL ARTERIAL DISEASE OF THE LOWER LIMBS.) E 11466 ppedall d'Italia Chirurgia 19i4-5): Blumchen, 0., Kiefer, H., Roskamm, H., Y/5-94, OET=WBVr9t8, ItalianAbs.) Waldmann, D., Buchner, Ch., and Reindell, H. A brief survey of the clinical VEROLEICH DER KORONARANGIOGRAPHISCHEN features of peripheral chronic BEFUNDE VON 127 PATIENTEN MIT ANAMNESE, obliterative arteritis and of the RISIKOFAKTOREN FUR KORONARE different therapies commonly applied, HERZERKRANKUNG, RUHE-UND BE1ASTUNGS- is followed by the description of the EKG. (COMPARISON OF CORONARY ANGIO- anatomical and physiological premises GRAPHIC FINDINGS IN 127 PATIENTS WITH on which the method of lumbar CASE HISTORY, RISK FACTORS FOR CORONARY gangliectomy is based. The short-term HEART DISEASE, AND EKG AT REST AND and long-term results achieved by this DURING WORX.) Zeitschrift gm method in 83 patients from 1950 Xreislau_fl. rsch 58(2)1141=67, Feb through 1965 are presented.Although 1.'969, German s.) the other therapies are also very effective, it may be maintained that Cornonaryangiography was performed on gengliectomy is a very important modern 127 patients using the method of surgical intervention which achieves Paulin. For coronary angiographic excellent results. (Author Abstract) findings the following classification was used: normal, slight sclerotic changes, moderate obstruction (lipss than E 11542 50 percent), severe obstruction (more Reale, A., Oioffre, P. A., D'Intino, than 50 percent), occlusion.The angio- S., and Veetri, A, raphic findings are compared with: STUDIO NELL'UOMO DEGLI EFFETTI 1). History of angina pectoris, EMODINAMICI DI ALCUNI FARMACI 12) risk factors for coronary heart CORONARICI E CONSIDERAZIONI SUL LOBO disease (hypertension, hypercholesteremia, MECCANISMO DI AZIO1E. (CLINICAL

221 a- 5 E 1154? (continued) E 11548 study of the hemodynamic effects of Malmejac, J., Schlet:terer, M., Clostre, some coronary drugs and consideraZions F., and Roux, A. on their mechanism of action.) SUR LIIMPORTANCE DES SECRETIONS Atti della Societe Italians di MEDULLOSURRENALES DANS IA rfariBT8Ta 2[1-4):(4-6, Ju1-T966, PRODUCTION DE LIHYVERTENSION PAR a n a.) IA NICOTINE. (THE IMPORTANCE OF THE MEDULLO-ADRENAL SECRETIONS IN The therapy of acute and chronic HYPERTENSION INDUCIO BY NICOTINE.) coronary insufficiency was investigated Comptes Rendus d.a Seances de la using trinitrin, nicotinic acid, Societe 2113-717413e-Wrai-see dipyridamole, aminophylline, isoproterenol, FirriaTa-1.6217): 276707-FWV-8, 1969, and a blocker of beta-adrenergic PFECTI-TAbs.) receptors (Trasicor). The parameters under investigation were the left A sufficiently high doeage of ventricular pressure, aortic pressure, nicotine induces a hypertension which heart rate, cardiac capacity and evolves in 2 phases, (1) a very rapid coronary flow. The studies indicated surge in arterial tension which is of that there may be a multiplicity of nervous origin, and (2) a slower rise factors which intervene in the with a "dome" effect which is of mechanism of action of coronary drugs. adrenalinic, medullo-adrenal origin. Each drug usually possesses more Medullo-adrenal participation was - than one method of attack with effects evaluated by using an adrenal short- diametrically opposite to some circuit in a heparinated, chlorslosed parameters which can lead to an equal dog under eimilar conditions whether result.It aleu appears that coronary or not the adrenals were in the circuit. flow is perhaps the least important The tests showed that medullo-adrenal element in the therapy of acute coronary participation is incontestably insufficiency, intervening in a more important, and can come into play with significant manner in the treatment weak doses of nicotine. With higher of chronic insufficiency. and higher doses of nicotine, the nervous mechanisms progressively become more pronounced and the E 11546 hypertensive surge at the debut can Widmer, L. K., Hartmann, 0., Duchoaal, exceed the secondary dome. With high F., and Plechl, S.-Ch. doses (200 to 500 mcg/kg), the nervous RISIKOFAKTOREN UND OLIEDMASSENARTERIEN- and adrenalinic mechanisms are at their VERSCHLUSS. (RISK FACTORS AND ARTERIAL maximum. OCCLUSION OF THE LIMBS.) Deutsche Medizinische Wochenschrift 94(21): 1107-10, May 23, 1969, (arman (Abs.) E 11559 Greenspan, K., Edmands, R. E., Knoebel, A total of 277 patients with S. B., and Fitch, C. arterial occlusion of the limbs were SOME EFFECTS OF NICOTINE ON CARDIAC compared with 2,082 subjects of the AUTOMATICITY, CONDUCTION, AND INOTROPY. Basel Study I having no evidence of Archives of Internal Medicine 123(6]: arterial occlusion. Systolic 707-12, Jun 1969. hypertension, elevated betalipoprotein levels, and heavy cigarette smoking were more frequent in the occlusion E 11561 group than in the control group. Vessey, M. P. and Doll, R. The in'idence of overweight as a risk DfVESTIOATION OF RELATION SEMEN factor, however, was not more USE OF ORAL CONTRACEPTIVES AND pronounced in the occlusion group. THROMBOEMBOLIC DISEASE. A FURTHER In the occlusion group, practically REPORT, British Medical Journal no individual was free of risk 2(5658):6E1-777urlTr7r93 factors and more than half had two or more risk factors. In the healthy group, the situation was reversed, E 11569 three-fourths had not a single or Russo, O. only one risk factor. Arterial L'INATTIVITA FISICA QUALE FATTCRE DI occlusion and coronary heart disease RISCHIO E DI LETALITA NELL'INFARTO had a similar age- and sex distribution DEL MIOCARDIO, (PHYSICAL INACTIVITY and often occurred together. The AS RISK AND LETHALITY FACTOR IN striking parallel between the two My0CARDIAL INFARCT.)Clinics Europe& disorders is of significance in that 7(6);806-27, Nov-Dec 1866, Italian (Ate.) the presence of one disorder may indicate the necessity for preventive Statistical data, experimental research therapy of the other. and the evaluation of epidemiological 22222 E 11569 (continued) E 11575 (continued?(continued studies have been deemed to constitute 5, 1969, French proof of the importance of physical inactivity in the incidence and severity of Smoking and drinking habits and the myocardial infarct.One research Indicated degree of atherosclerosis were studied that while smoking clearly favored the in 1,019 cancer patients who had died development of the initial myocardial in- at Roswell Pa,,k Memorial Hospital between farct, double that in nonsmokers, it had 1956 and 1964. Aorta were removed upon no significant relationship to the autopsy and studied. The investigation prognosis immediately following infarct, showed that an association existed be- i.e., within the first four weeks. tween aortic atherosclerosis and smoking, Early mortality from infarct, in smokers the association being the more pronounced and nonsmokers alike, was influenced by with the duration of the smoking habit the degree of physical activity prior to and the increasing number of cigarettes the intervention of infarct. smoked.Alcohol, however, had no apparent effect on the severity of the disorder. The relationship of age and aortic Indi,liduals E 11571 atherogenesie was constant. Ouimberteau, 3.-C. more than 70 years old had an aortic RESULTATS DE L'EXPERIMENTATION atherosclerosis 2 to 3 times more CLINIQuE DU PIRIDOXILATE EN PATHOLO3IE developed than individuals of the As for sex, aortic ARTERIELLE. (RESULTS OF THE CLINICAL youngest age group. EXPERIMENTATION OP PYRIDOXYLATE IN atherogenesis appeared to be more rapid ARTERIAL PATHOLOGY.) Bordeaux Medical in men than in women, but with age, the 2(3)673, 675-6, Mar193177PironEEW5.) severity in women approached that of men. Olyo 6 (pyridoxylate) was tested as a metabolic medication capable of influencing the cellular utilization of E 11591 oxygen in hypoxic tiscues. Fifty obser- Belyayev, I. I. vational (42 men and 8 women, 39 to 32 nPO51IEMAUrt561 CCEPX413-COCYAICT6/41 years old), 48 of whom suffered from 3A60JEdNIVIMBriiriC414ECKOMCCBBIEWN. arteritic lesions of the lower limbs in stages II to IV, formed the basis of PROBLEMA BORtBY S SERDECHNO- SOSYDISTYMI evaluation. Results of treatment were ZABOLEVANIYAMI V OIOIYENICHESKOM evaluated after 6 months. A beneficial OSVESHCHENII. (THE PROBLEM OF result was obtained in 34 of the 50 CARDIOVASCULAR DISEASES COMTROL VIEWED cases. Smoking previous to therapy had HYOUNICALLY.) Vetniks Akedemli no appreciable effect on the benefits of Meditsinskikh Nelah (5):48-56, treatment.As a whole, the results have 14.69, Russian (Abe.) shown that Olyo 6 can very often bring about a clear improvement or the dolorous Data on the prevalence of diseases functional syndrome and permit skin cica- affecting the organs of blood circulation and the resulting mortality in the Soviet trization in arteritin. Union and abroad were reported.Character- ization was given of the etiological factors implicated in the emergence and E 11574 Concours Medical. development of such common diseases of 1RAITEMENT DE LtANOINE DE POITRINE. the cardiovascular system as hypertension (A l'Exclusion de l'Infarctus du and diseases of atherosclerotic origin. Smoking, if not the main cause, in every Myocarde). (TREATMENT OF ANGINA PECTORIS (EXCLUDING MYOCARDIAL INFARCT).) case, was considered by investigators Concours Medical 91(14)12929, 291, to be a factor contributing to the develop- French (Abs. went of diseases of the circulatory organs. 2933-4,APSr/969, Alcohol was found to disrupt the vascular Five cases of angina pectoris, with regulatory processes and induce hyperten- the recommended thera;eutio and assoolated sion. Data regarding its etiological An abeolute role in the development of atherosclerosis measures, were presented. there suppression of tobacco was included in was found to be contradictory, but the hygieno-dietetic measures. was general agreement concerning its unfavorable influence in existing atherosclerosis.The report also E 11575 discsesed mayor social end hygienic Concours Medical. measures which should be carried out in ATHEROSC1EROSE DE L'AORTE, CIGARETTE controlling cardiovascular diseases ET ALCOOL. (ATHEROSCLEROSIS 0? THE in the Soviet Union. AORTA, CIGARETTES AND ALCOHOL.) Concours Medie91 91(14),2873 -4, Apr

223 a27 1.--,.

E 11596 E 11654 (continued) Deutacher, S., Epstein, F. H., and AORTIC ANEURYSM.Archives of Keller, J. B. Environmental Health 19RT:177-82, RELATIONSHIPS BETWEEN FAMILIAL Aug1969. AGGREGATION OF CORONARY HEART DISEASE AND RISK FACTORS IN THE GENERAL POPULATION. American Journal of Epidemiology 89(5): E 11657 5mm-ray-mg. Goldsmith, J. R. CARBON MONOXIDE AND HEART DISEASE. (Editorial Annals of E 11597 Internal Medicine 71 1)irgr=f017 Welborn, T. A., Cumpaton, G. N., Cullen, Jul. 190.. K. J., Curnow, D. H., McCall, M. G., and Stenhoure, N. S. THE PREVALENCE OF CORONARY HEART DISEASE E 11659 AND ASSOCIATED FACTORS IN AN AUSTRALINN Metcalfe, J., Dhindsa, D. S., Edwards, RURAL COMMUNITY.American Journal of M. J., and Mourdjinis, A. Epidemiology 89(5):5%-36: ITETIV119* DECREASED AFFINITY OF BLOOD FOR OXYGEF IN PATIENTS WITH LOW-OUTPUT HEART FAILURE. Circulation Research 25(1): E 11617 47-51, Jul 1969. Naval Research Reviews. JOINT CARDIOVASCULAR DISEASE STUDY.Naval Research Reviews 22(5):11, May 1969. E 11674 Wessler, S. BUERGER'S DISEASE REVISITED. Surgical E 11620 Clinics of North America 49(3): Heyden, S. and Gerber, C. J. (03-13, 7uh7r4'r. ATHEROSCLEROTIC CEREBROVASCUUR DISEASE--ITS NATURE AND MANAuf,MENT. American Journal of Medicine 46:763-73, E 11679 Mr1167. Frederiksen, H. ORAL CONTRACEPTIVES AND THROMBOEMBOLIC E 11631 DISEASE.British Medical Journal Keys, A. 4(5633):77TE5EMI7Org. CURRENT STATUS OF RESEARCH ON THE EPIDEMIOLOGY OF CORONARY HEART DISEASE. E 11695 Ja nese Circulation Journal 32:1669- Stamler, J., Mojonnier, L., Hall, Y., , ec 96'87------Berkson, D. M., Lindberg, H., Cohen, D. B., Epstein, M., Miller, W. A., E 11634 Soyugenc, R., and Barr, G. Hood, B., Tibblin, G., Welin, 0., Orndahl, PREVENTION OF ATHEROSCLEROTIC CORONARY G., and Korsan-Bengtsen, K. HEART DISEASE. Medicine Today 2(6/9/10) :1-40, Aug-Sep-Oct 1968. MYOCARDIAL INFARCTION IN EARLY AGE. III. Coronary Risk Prctora and Their Deficient Control. Acta Medica E 11730 Scandinavica 165(4):'2TI=M-7147 1969. Sgarbi, M. and Maacarello, M. L'INFARTO DEL MIOCARDIO NEI GIOVANI. E 11638 Osservazioni su di una Casistica di Walker, A. R. P. and Bersohn, I. Soggetti in eta Inferiore al 40 Anni. MEMORANDUM: WHAT CAN BE DONE TO AVOID (MYOCARDIAL INFARCTION IN YOUNG SUBJECTS. Observations in a Orou CORONARY HEART DISEASE? South African of Patients Medical Journal 43(14):387717A707717-1-969. Under 40 Years of Age. Minerva Cardloangiologica 17(6 13:364 -12Jul 1969, Italian [Abs.) E 11639 Mulcahy, R., Hickey, N., and Maurer, B. After a survey of the literature on THE VALUE OF RETROSMTIVE SURVEYS IN the incidence and features of myocardial infarction under 40 years of age, a group THE STUDY OF CORONARY HEART DISEASE. of 27 cases is reported. Public Health 83(4):176-84, May 1969. The conclusion is reached that myocardial infarction in young subjects is becoming less uncommon E 11654 than formerly and that it is lees severe Hammond, E. C. and Oarfinkel, L. than in old subjects on account of the CORONARY HEART DISEASE, STROKE, AND lower death rate, whereas it shows no special clinical features.The aetio-

224 E 11730 (continued) E 11738 (continued) pathogenesis requires further investi- differences in the subjective and gation. (Author Abstract) objective findings within the three B oole' groups as blue-collar workers, employees, and civil servants. (Author E 11732 Abstract) Preuss, Hausler, M., and Seige, K. OBLITERIERENDE ARTERIELLE SYSTEMER- KRANKUNGEN BEI ?RAVEN. (OBLITERATING E 11743 DISEASES OF THE ARTERIAL SYSTEM IN Hfross, W. H., Schmitt, O., Junge-Hulsing, WOMEN.) Deutsche Oesundheitswesen 24 O., Themann, H., and Kienecker, B. (13):577-$77MTF-27, 2969, sermon (Abs.) OUR PATHOGENESE DER HYPERTONIEBEDINGTEN OEFASSSKUROSE. (PATHOGENESIS OF Female smokers (34.6 percent) got ill HYPERTENSION- CAUSED VASCULAR SCLEROSIS. on the average 8.3 years earlier than Zeitschrift fur Kreislaufforschung58(d: those who did not smoke. Obesity has tr7M7WilIgT, German tabs.) been a symptom of the women with vascular diseases younger than 50 years. The Fifty rabbits, in which arterial older patients showed overweight. hypertension had been induced by the Seventy-five percent of the women suffer- celloctsne method of Page were killed at ing from arterial vascular diseases show- diM4ent intervals after the onset of ed chronic hypertension, 43 percent of hypeztinsion 43., ware compared to fifteen them a serious hypertonia of the blood. normPl rabbits... The aortae and carotid The numerous pathological excitations arteries weiccised and studied under in the electrocardiogram (61.4 percent) the electron microscope and light micro- and the corebro-vascular affection (9.2 scope (HE, Astra blue, PAS, Resorcinol- percent) have to be regarded as the Fuchein, in combination with Astra blue, expression of a generalized angiopathy. Van Gieeon and Sudan III staining). At Thirty women (16.2 percent) with a time, at which no other macroscopic, peripheral arterial obliterations suffer- microscopic or electronoptic structural ed from a manifest diabetes mellitus. changes could be discerned, the aortae and The peripheral arterial obstruction of arteries of the hypertension animals the females is of secondary interest with showed a consistent and definite increase respect to Working and social medicine. in mesenchymal substances in all areas of the vessel wall, particularly in the sub- endothelial space.The results enforce E 11738 the validity of our previous statements Blohmke, M., Schaefer, H., Abel, H., that dieturbances in the mesenchymal meta- Depner, R., Oruntzig, A., Koschorreck, bolism of the vessel wall are primary and B., and Stelzer, O. obligatory in development of arterioscler-. MEDIZINTSCHE UND SOZIALE BEFUNDE BEI osis. Lipidosis, calcinosis and necrosis KORONAREN HERZKRANKHEITEN. (MEDICAL of the vessel wall as well as thrombotic AND SOCIAL FINDINGS IN CORONARY HEART processes are important but secondary DISEASES.) Munchener Medizinimche events which occur as a consequence of Wochenschrift 11I1I31:101-1U, Mar 28, the disturbed nesenchymal metabolism. 1 3-61, German (Abe.) Arteriosclerosis is not a disease of aging, it is neither a disease of lipid- or The population studied consists of cholesterol - metabolism nor blood coagul- 1039 Heidelberg Local Government person- ation, it is primarily a reaction disease nel and was examined in the aummer of of the mesenchyue in the vessel wall, 1967. The response rate was 82 percent Which may be induced by a variety of non- of all men between the ages of 40 and specific noxious agents. (Author Abstract) 59 eligible for inclusion in this study. Various subjective symptoms and ECG findings were the criteria for the E 11752 establishment of the five groups of Reeine, O. and Chiavaro, A. Persona suspected of suffering from Coro- COMPCIRTAMENTO DI ALCUNI PARANETRI nary heart diseases. These groups were EMOMNAMICI DURANTE EFFETTO DEL FUMO compared with another group of persons DI SIOARETTA IN CONDIZIONI DI RIPOSO without any subjective symptoms or ECG E DOPO LM/ORO MUSCOLARE IN SOGOETTI CON findings.The five groups differed in ANGOR DA SFCRZO, FUMATORI E NON FUMATORI. part considerably from the control group (ACTION OF SEVERAL HEMODYNAMIC PARAMETERS and/Or from each other in some physiolo- UNDER THE INFLUENCE OF CIGARETTE SMOKING gical data.Further the persons of those UNDEP CONDITIONS OF REST AND AFTER groups complained more often of vegeta- PHYSICAL WORK IN SUBJECTS WITH ANGINA UPON tive troubles than the persons of the EXERTION, SMOKERS AND NONSMOKERS.) Atti control group.Significant differences dells Societe Italiana di Cardiologii--- could be stated also in the frequency of 2Tr-4T3112-5; rul 1968,-7/Alien (Abs.) some social variables. There were also

225 E 11752 (continued) E 11754 (continued) cholesterolemia, increases in coagul- The immediate effects of cigarette ability and towards psychoeocial and smoking on the cardiovascular apparatus occupational factors.A schematic of man was atudied.Specifically, an in- account is also given of the moat vestigation was performed on the effects modern views relating to its treat- of smoking, under conditions of rest and ment and prevention. (Author Abstract) after physical labor, on cardiac frequency, arterial pressure, the electrocardiogram, and peripheric rheographic waves in E 11765 normal subjects and in coronary subjects Halhuber, M. J. with etem.cardia (both smokers and non- PRAVENTION UND REHABILITATION BEI smokere), divided into groups of 11 each. ISCHAEM13CHER HEREERKRANKUNG. (PRE- Findings on the normal nonsmoking subjects VENTION AND REHABILITATION IN both at rest and during smoking were as ISCHEMIC HEART DISEASE. Zeitschrift follows; An increase in cardiac frequen- fur Gerontologa 2(2)193-1 ,FIZZ-717-11%9, cy of plus 10 to plus 21 percent; an in- Te-Fmn11a s. cream in general arterial pressure of plus 11 to plus 27 percent; and plus 15 After a definition and explanation to plus 33 percent, respectively, in of primary aril secondary prevention, systolic pressure and diastolic pressure. rehabilitation and the role of longterm No change was observed in the electro- treatment in iachemic heart disease, cardiographic test. Upon muscular ex- the author evaluates critically in ertion, it was noted that both cardiac this survey the present epidemiological frequency and arterial pressure increased and experimental knowledge about risk during smoking. In the normal smoking factors as a basis of preventive card- subjects, at rest and under the influence iology. The practical conclusions of smoking, more evident increases in for comprehensive care of patients cardiac frequency (plue 22 to plus 35 with ischemic heart disease are put peretnt) and in arterial pressure in three hypotheses. (1) The multi- (plus 20 to plus 38 percent for the causal (comprehensive) etiology of systolic values and plua 25 to plus 49 coronary heart disease has to cor- percent for the diastolic) were noted. ltspond with a multiple individual Exertion before smoking produced an in- comprehensive care program of pre- crease in rheographic waves, while ventive measvrea in which drugs exertion during smoking produced a play a minor part. (2) Preventive reduction. Among the angina subjects, cardiology as adapted epidemiology both smokers and nonsmokers, at rest and of risk factors has to use many under the influence of smoking, an different methods and results of increase in cardiac frequency and general medical specialties such at diet, arterial pressure was observed. It was physical activity and sport, psyco- concluded that cigarette smoking provoked therapy, physical therapy, health an increase in cardiac frequency and in education, longterm drug management, the systolic and diastolic values of the presymptomatic diagnoaie. (3) Re- general arterial pressure, and a reduction conditioning centers which are able in the peripheric rheographic waves. to really integrate these measurea and the necendary health education seem to be a way to realize the E 11754 purposes of secondary prevention in Terzuolo, D. Central Europe for a maximum of EPIDEMIOLOOIA, PATOGENESI E PRLFTLASSI cardiac patients. These hypo- DELL,ATEROSCLEROSI. (SOME MEDICOSOCIAL theses as the result of 2 years CONSIDERATIONS WITH RESPECT TO THE experience in a Bavarian Recon- EPIDEMIOLOGY, PATHENESIS AND PROPHYLAXIS ditioning Center have to be OF ATHEROSCLEROSIS. Archivio ar le proved by five years-statistics. Scienze Mediche 125 10)1542-50,75Ft In othercountrieswith different rnr,"-nrrrerrrAbs. traditions other ways (for example the comprehensive care of a private The moat recent data concerning the patient in a health club) may be pathogenetic and epidemiological features useful.The need of standardiza- of atherosclerosis ars considered by way tion of diagnostic measures and of laying emphasis on the medicosocial functional tests in the evalua- importance of the prophylaxis of this tion of work capacity during exer- diaease in the fight against cardio- cise is discussed and a new class- vasculopathy. The various factors that ification of patients after myo- contribute to the setting-up of athero- cardial infarction is proposed. sclerosis are analyzed and particular (Author Abstract) attention is directed towards hyper-

226 2.36 E 11766 E 11781 Romagnoli, 0., Marinoni, A., and Torre, E. Kennel, W. B., Schwartz, M. J., and VALUTAZIONE DI ALCUNI INDICI ANTRO- McNamara, P. M. POMETRICI E STRUMENTALI IN RELAZIONE BLOOD PRESSURE AND RISK OF CORONARY ALLA FATOLOGIA CRONICA NON INFETTIVA. HEART DISEASE: THE FRAMINGHAM STUDY. (EVALUATION OF SOME ANTHROMMETRIC DL:eases of the Chest 56(1):43-52, AND INSTRUMENTAL INDICES IN RELATIO TO CHRONIC NONINFECTIVE PATHOLOGY.) Giornale di Igiene e Medicine raven Ivir914):291.78, Oct-Dec 1968, E 11793 Italian cAbs.) Chiang, B. N., Perlman, L. V., Ostrander, L. D., Jr., and Epstein, F. H. The Author:: present the results RELATIONSHIP OF PREMATURE SYSTOLES TO obtained from a longitudinal study CORONARY HEART DISEASE AND SUDDEN DEATH in order to evaluate iTme risk factors IN THE TECUMSEH EPIDEMIOLOGIC STUDY. for ischemic heart diseases. The Annals of Internal Medicine 70(6)1 results reconfirm as predisposing TrgrEt, Jun 1907 factors: high h1c.od pressure, die- lipedemia, a tv.:itive family history and cigarette sm:;,,ng. (Author Atstract) E 11794 Toiler, O. B., Saker, B. M., Rollo, K. A., Burvill, M. J., and Stenhouse, N. E 11773 ELECTROCARDIOGRAM OF THE SOCIAL Jouve, A., Rochu, P., and Avril, P. DRINKER IN PERL!, WESTERN AUSTRALIA. ENQUETES EPIDEMIOLOGIQUES SUR L,- British Heart Journal 31(3):606-13, ATHEROSCLEROSE DANS LA REGION PROVENCALE. Ray 1969. (EPIDEMIOLOGICAL INVESTIGATIONS OF ATHEROSCLEROSIS IN THE PROVENcE REGION.) Union Medicale du Canada 98(5):761-6, E 11812 Mirrag7/07E-Tch-Mil- Frantz, I. D. and Moore, R. B. THE STEROL HYPOTHESIS IN ATHEROGENESIS. The study was conducted on 1,229 American Journal of Medicine 46(5):684-90, subjects with coronary disease, 669 May 1969'. with obliterative arteriopathy of lower limbs and 743 controls.Ten different factors were examined and the main E 11814 conclusions were: (1) The most important Frets, E. D. predisposing factors leading to coronary HYPERTENSION AND ATHEROSCLEROSIS. disease in men were familial tendency, American Journal of Medicine 46(5): android biotype (often associated with 715-41371471759. excessive body weight), compulsive neuro- ais, arterial hypertension, elevated blood levels of lipids, glucose and uric E 11615 acid, exceasive food intake, especially Morris, J. N. and Gardner, M. J. fat, and heavy smoking habits. (2) In EPIDLMIOLOGY OF ISCHAEMIC HEART DISEASE. women with coronary disease, the presence American Journal of Medicine 46(5):674-83, of masculine traits and arterial hyperten- May 1969. sion are most prevalent. (3) In patients with chronic arteriopathy of lower limbs, the same factors seem to be at play, E 11816 except for obesity, heredity and abnormal Dayton, S. and Pearce, M. L. personality traits. (Author Abstract) PREVENTION OF CORONARY HEART DISEASE AND OTHER COMPLICATIONS OF ATHERO- SCLEROSIS BY MODIFIED DIET. American E 11778 Journal of Medicine 46(5):751-62, May Dawber, T. R. THE RISK OF CORONARY HEART DISEASE. Heart Bulletin 18(3):43-6, May-Jun 1969. E 11820 Chedd, O. and Stubbs, P. E 11779 SMOKING MAY NOT CAUSE CORONARIES. Allison, R. D. and Roth, O. M. New Scientist 43(5)1222, Jul 31, 1969. CENTRAL AND PERIPHERAL VASCULAR EFFECTS DURING CIGARETTE SNOKINO. Archives of Environmental Health 19(2):179 --7717 E Aug 1969. Wyndham, C. H. THE PROBLEM OF CORONARY HEART DISEASE WITH SPECIAL REFERENCE TO THE INFLUENCE

227 2,31 E 11821 (continued) E nue (continued) OF PHYSICAL ACTIVITY. South African feared apoplectic strokes.The investi- Medical Journal 43(?3):77071,7a577 gation has shown that the damaging factors in both diseases have a certain simi:arity.These factors are blood pressure, cholesterol level, overweight, E 11825 diabetes, hemoglobin concentration and Mercier, J. N. smoking. Smoking was found to be an LA MEDECINE DU TRAVAIL ET L'INSUFFISANCE important factor in the development of CORONARIENNE. (INDUSTRIAL MEDICINE AND Cahiers de apoplexy and coronary disease but the CORONARY INSUFFICIEMY.) mechanism of action is not known.The Medecine Interprofeusionneln- TMIT significance of the relationship of the 507T7T766, French (WM" different factors to all types of apoplexy and arteriosclerotic-thrombotic Detection of risk factors such as cerebral infarct was discussed. vascular heredity, obesity, diabetes, lipidic anomalies, and excessive smoking (more than 20 cigarettes daily, especially when inhaled) can lead to the isola- E 11830 Vachon, J., Oratadour, C., and Facquet, J. tion of a nonnegligible percentage LE TRA/TMENT DE L'ARTERITE DES MEMBRES (2 to 5 percent) of Individuals, INFERIEURS AU CABINET DU PRACTICIEN. even without clinical symptoms, who are (TREATMENT OF ARTERITIS OF THE LOWER especially endangered.The report LIMBS IN THE PRACTITIONER'S OFFICE.) outlines the measures for treatment of Revue du Practicien 18(39s126-32, the two forms of conmary insufficiency: (1) acute (in practice myocardial in- re-7,79trenc (Abs. farct) and (2) chrorvi.c (in practice, angina pectorisand the prognosis for Treatment has two primary objectives: (1) to oppose the arteriosclerotic complete or partial re-entry into disease which is at the root of the professional life. arteritiB (general treatment) and (2) to improve the circulation of the affected limb (local treatment). The E 11826 Sehnert', G. and Kahlks4 W. proportion of heavy smokers among these patients is very high, from one- DIE THERAPIE DER FRIMAREN HYPERLIPIDA- to two-thirds, a000rding to statistics, MIEN. (THE THERAPY OF PRIMARY HYPER- although 10 to 15 percent (excluding LIPEMIAS.) Deutsche Mediz1nische Wochenachrift 94(71071:327-Mir4, the women) have never smoked. It has 1969, German (Abt. also been observed that the arteritice who continue to smoke more frequently The differentiation and the dietetic develop ischemia and require amputa- and drug treatment primary hyperlip- tion. emiaa (hypercholestesemia, exogenous and Endogenous hyperglyddemia, and Type III hyperlipemia) were discussed. The E 11831 controlled long-term treatment of patients Tashbekov, B. U., Davydov, Ya. S., with primary hyperchclesteremia and and Bolotova, M. N. AoriVAIIKKOAYCTA11043KA WtAormnaio primary hyperglycidesia, because of 3,4-601141MA 6 ATm0O4Eamom BaSaxt. the high risks of arteriosclerotic KaitgaiTPALIM heart- and vascular-diaeases, must neces- ASPIRITSIONNAYA USTANOVKA DLYA sarily include the control of other OPREDELENIYA KONTSENTRATSII 3,4- risk factor.: such as cigarette smoking, BENZPIRENA V ATMOSFERNOM VOZDUKHE. high blood pressure and overweight. (ASPIRATION APPARATUS FOR THE DE- TERMINATION OF 3,4-BENZOPYRENE IN ATMOSPHERIC AIR.) Mediteinskli E 11828 Zhurnal Uzbekistana (3)s66-8, Mer Dswber, T. R. and Thomas, H. E. 11=7-ruesian (Abs.) DIE EPIDEMIOLOGIE DES SCHLAGANTPALLS. A portable aspiration apparatus (THE EPIDEMIOLOGY OF LPOPLEXY.) Dertsches Medizinischra Journal 20(1)s for the determination of 3,4-benzo- It has d 33-43, Jan 5,-1967, CurciEN-1717.) pyrene in air is described. capacity of 9-10 cu. m. of air per The original Framingham study on hour. As the volume of air required coronary disease luis teen extended to for one teat is from 250 to 400 cu. m., the investigation of apoplexy and the length of time required per test arteriosclerotic-thrombotic cerebral is from 3 to 5 days. infarct.During the 11 -year open from the beginning of the study, 133 persons in the investigated ago groups had auf-

223 Z32. E 11832 E 11842 (continued) Abdullaev, R. A. public to accept changes in living KDuroCY WACHOMIGI N EEYEISIX habits. One group has suggested that MANOR mak. doctors, psychologists, and sociolo- K VOPROSY DIAGNOSTIKI I LECHENIL gists study the best means of reaching GRUDNOY ZHABY. (THE QUESTION OP the masses. DIAGNOSIS AND TREATMENT OF ANGINA PECTORIS.)Meditsinskii Zhurnal Uzbekistan 10:3-9, Feb SJST-Tussian E 11855 716177---7- Lang, V. O. BLUTDRUCKWIRKSAMKEIT ORALEE KREISLAUF- In a review of the etiopathogenesis, MITTEL. (BLOOD PRESSURE EFFECTIVENESS diagnosis and modern methods of treat- OF ORALLY-ADMINISTERED CIRCULATORY ment of angina, it is mentioned that SYSTEM DRUGS.) Internistische Praxis it is imperative that the heart patient 9(1):149-50, l459, German (Ats7T---- should abstain from smoking, since nicotine not only constricts the Depot-Effortil and Novadral- blood vessels but also lessens the retard pills were adminietered to 15 effect of druga. male and female students, free of circulatory disturbances in double blind tests.Alcohol, nicotine and coffee E 11634 as well as the use of other drugs were Medizinischo Klinik. forbidden before and during the tests. ZIGARETTENKONSUM UND HERZTOD. (CIGARETTE The testa showed that both drugs had a CONSUMPTION AND DEATH FROM HEART DISEASE.) more certain blood pressure effectiveness' Mediziniache Klinik 64(2):84, Jan 10, than the placebo, and that even admin- 1969, German 7677 istration of 2 pills had no action under at-rest conditions.This last was in This le a comment on C. C. Seltzer's contradiction to the data of the C. H. report in the January 1968 issue of the Boehringer firm in their brochure Journal of the Amsrican Medical Associa- regarding similar tests. tion wherein he evaluated the findings of 29 epidemiological investigations, E11 e56 (including the 1964 Terry Report) which Blohmke, M., Schaefer, H., Abel, H., appeared from January 1964 to May 1967. Depner, R., Gruntzig, A., Koachorreck, B., Seltzer concluded that the investigations and Stelzer, O. have not proved the connection between RESULTATS DUNE ENQUETE MEDICALE ET cigarette smoking and the excessive SOCIALS SUR LES AFFECTIONS CORONARIENNES. forms oT coronary disease and their (RESULTS OF A MEDICAL AND SOCIAL lethalit., or that cigarette smoking INVESTIGATION OF CORONARY DISEASES.) can cause coronary disease. To Cahiers du Colle e de Medecine des date, he maintained, no valid con- nalTanee ar s 737703779(, -Frar nection has been proved between the 1969,-Frerah-trEW.) duration of cigarette smoking and death as a consequence of coronary A group of 1,039 men, 40 to 59 disease. Whether inhalation of the years of age, employees of the City of smoke has harmful effects 13 still Heidelberg, were examined in the summer considered an open question. of 1967, with 82 percent participation of the men interrogated. Based upon E 11842 subjective symptoms or E.K.O. data, the Minerva Medica. men were arranged in 5 different groups LIO.M.S. E LE CARDIOVASCULOPATIE. in which coronary disease was suspect. (W.H.O. AND CARDIOVASCULAR DISEASES.) These subjects were compared with a Minerva Medica 59(6, Suppl 75):29-30, control group with no symptoms or E.K.O. Sep 196871T-Tian (Abs.) anomalies. The 5 groups differed from the control group and/or themselves The regional office of the World by certain eignificant parameters.The Health Organization for Europe has suspect subjects presented subjective symp- proposed an intensification of its toms or E.K.O. alterations, and complained program, beginning in 1968, for more frequently of vegetative troubles obtaining data useful in limiting than the control group. The incidence dangers of ischemic heart disease. of certain variables of eoc'_al order Some doctors have upheld the neces- In the 5 groups showed significant sity for some general rules to pre- differences in comparison with the vent or retard coronary disease by control group. One could observe limitation of caloric and fatty acids differences in the incidence of sub- intake and cigarette consumption. jective and objective signs among the Methods must be found to persuade the 3 occupational groups studied (workers,

229 E 11856 (continued E 11867 clerks,officialsi. In all suspect Hess, H. groups, the tolerance to alcohol was BEHANDLUNG DER CHRONISCHEN EXTREMITA- reduced and the consumption of cigarettes TENARTERIENVERSCHLUSSE. (TREATMENT OF lower in the patients with infarct which CHRONIC ARTERIAL OCCLUSIVE DISEASES OF had been detected on anamnesis. THE EXTREMITIES.)Deutsche Medizinische Wochenschrift 94(24):1295-6, 1969, German (Abs.) E 11859 Frisch, P. The conservative symptomatic, throm- DIE KONSERVATIVE BEHANDLUNG DER bolytio, surgical, and preventive treat- ARTERIELLEN VERSCHLUSSKRANKHEITEN. ments were briefly discussed. In the (THE CONSERVATIVE TREATMENT OF author's opinion, endangiitis obliterana ARTERIAL OBLITERATING DISEASES.) can be checked if the inhalation of to- Medizinische Klinik 64(8):323-6, bacco smoke can be avoided. If other risk Feb 21, 1969,-alwan (Abs.) factors such as hypertension, hyperlipemia, diabetes mellitus, and hyper- The various methods of treatment uricemia exist, dietetic or medical were discussed. It was stated that a measures may be applied. proper choice of druga in combination with systematic exercise and phyaico- mechanical and balneological methods E 11873 could bring about improvement, not Glashoff, E. only in the initial stages but often ZUR BEHANDLUNG ZEREBRALER UND with existing necrotic or gangrenous PERIPHERER DURCHBLUTUNGSSTORUNGEN IN states, through the development of a DER PRAXIS. (TREATMENT OF CEREBRAL functional collateral circulation. AND PERIPHERAL CIRCULATORY DISTURBANCES All general measures are ineffective IN THE PRACTICE.) leraple der Gegenwart or temporary at beat if the patient 108(1)t88, 90-2, 94- , J&H-ignr, is not convinced of the necessity of German (Abs.) absolute nicotine abstinence. Cosaldon pills (200 mg 1-hexy1-3,7- dimethylxanthine + 50 mg nicotinic E 11862 acid) were administered to 26 patients Schoop, W. (18 women, 8 men) all but 2 of whom PATHOGENESE, PATHOLOGISCHE PHYSIOLOGIE were above 50 years of age. Cosaldon- UND DIAGNOSTIK DER ARTERIEL1EN retard pills (400 mg of the xanthine VERSCHLUSSKRANKHEITEN. (PATHOGENESIS, derivative + 100 mg nicotinic acid) PATHOLOGICAL PHYSIOLOOY AND DIAGNOSIS were administered to 52 patients OF ARTERIAL OBLITERATING DISEASES.) (31 women, 21 men) about half of Whom Hippokrates 40(6):219-22, Mar 31, 1969, were above 70 years of age. Improve- German (Abs.) ment was observed in 64 patients, with no change in 14 patients. The incidence of the so-called Practically no side-effects were noted arterial obliterating diseases, based with the newer preparations. Results on recent investigations, is much of treatment in 2 select cases, a 90- greater than previously thought.The year -old an with cerebral sclerosis and obliterating processes generally general sclerotic circulatory distur- develop slowly and usually go unnoticed bances and a 78-year-old woman with for a long time.Major cause is intermittent claudication were also cigarette smoking with diabetes, hyper- presented. tension and hyperlipemia also repre- senting important endogenous factors. Diagnosis in moat cases can be made E 11880 by simple methods such as pulse U. S. Depa,,tment of Health, Education, and palpation, arterial auscultation and Welfare, Public Health Service. oacillography. An angiogram is CEREBRAL VASCU1AR DISEASE AND STROKES. usually necessary only if surgical U.S. Department of Health, Education, and measures appear indicated.A com- Welfare, Public Health Service, National plete diagnosis should include Institutes of Health, Bethesda, Md., Public evaluation of the cordial and cerebral Health Service Publication (513), Health blood supplies which are often damaged Information Series No. 116, 1969, pp. 3-19. in patients with disorders of the arterial circulation.

30 a^Z E 11883 E 11927 (continued) Burns -Cox, C. J., Doll, R., and Ball, as diabetes and hyperlipemia, latent and K. P. manifest cardiac insufficiency, and smok- SUGAR INTAKE AND MYOCARDIAL INFARCTION. ing were not properly controlled.One- British Heart Journal 31(4):485-90, third of the overweight patients had not Jul 1969. reduced further. Only one-fourth of the hypertensives and only one-half of the patients with cardiac insufficiency phe- E 11884 nomena had remained on effective therapy. Rytel, A. Alcohol consumption was reduced only PROF. EDWARD ZEBROWSKI, PIONEER IN THE elightly and approximately one-third of STUDY OF THE ADVERSE EFFECTS OF the smokers resumed the smoking habit in TOBACCO OU THE CARDIOVASCULAR SYSTEM. the postinfarct period (26 percent as Polish Medical Science and History compared with 72 percent before infarct). 12(3):13=77-.Tul1969. A slightly higher percentage of lethality was observed in connection with resumption of smoking. The report also discussed E 11888 the effect of therapy and the physical, Suzuki, K. psychic and occupational rehabilitation EXPERIMENTAL STUDIES ON MORPHOGENESIS OF of the affected patients.Fifty-seven ARTERIOSCLEROSIS, WITH SPECIAL REFERENCE (19 percent) died during the investigation TO RELATION BETWEEN HEMODYNAMIC CHANOE which was conducted in the Ludwigshafen AND DEVELOPMENTS OF CELLULOFIBROUS Medical Clinic from 1960 to 1965. INTIMAL THICKENING AND ATHaliOSCLEROSIS. Ounce Journal of Medical Sciences 1171=41111M-4437birrnri. E 11928 Novaro, A. DIAGNOSI E CUBA DEI DISTURBI PSICHICI E 11913 NELIE CORONAROPATIE. (DIAGNOSIS AND Miller, A. CURE OF PSYCHIC DISTURBANCES IN CORONO- ADVANCES IN CARDIOLOGY. Manitoba Medical PATHIES.)Flkaaegne Internazionale di Review 49(5):136-9, May 11E77-- Olinica e TiTilti7TR(5):312-7, Mar IT, 1969, Itilian (Abs.)

E 21921 The psychic disturbances in coronary Greenberg, L. D. and Gonzalez, I. E. diseases are very fr.,quent and can be INFLUENCE OF FATTY ACID COMPOSITION OF distinguished as: (1) Disturbances which INFANT FORMULAS ON DEVELOPMENT OF ARTERIO- Precede or accompany coronary diseases SCLEROSIS. Experimental and Molecular and which sometimes cause them by a. Pathology 10(3):240 -9, JuiTT9E9. psychosomatic pathogenesis (anxiety neurosis and depressive psychoneurosis); (2) disturbances which follow coronary E 11e23 diseases and consist in part of neuroses Insull, W., Jr., Lang, P. D., Hsi, B. P., and psychoses considered from the view- and Yoehimure, S. point of (1) and in part secondary neu- STUDIES OF ARTERIOSCLEROSIS IN JAPANESE roses induced by suppression of the AND AMERICAN MEN. I. Comparison of tobacco habit and alcohol end sometimes Fatty Acid Composition of Adipose Tissue. originating in suvere dietary cures which Journal of Clinical Investigation 48(7): were undertaken to reduce a possibly ISTISZT ,7urr7677- excessive body weight.Sometimes these primary and secondary neurosea intertwine and condition each other. Particularly E 11927 serious are psychodepressions which might Gillman, H. and Colberg, K. indicate a tendency towards suicide. Good UNTERSUCHUNGIN USER DIE LEBENSPHASE therapeutic results have been obtained with MACH UBERSTANDENEM HERZINFARKT. (IN- repeated cycles of intramuscular injections VESTIGATIONS OF THE LIFE PHASE AFTER of chorionic gonadotropic hormones, muscu- SURVIVING MYOCARDIAL INFARCT. Deutsche lar exercise especially in the practice of Medizinische Wochenschrift 94 18 sports, and psychotherapy. Four case his- D33-9, May 2, ITER, German (Abs. tories were also presented.

In 300 patients who had survived Wocardial infarct for 1 to 5 years E 11929 (average 3-1/2 years), the chief risk Krueger, O. A. W. factors still had an unfavorable influence ZURBEHANDLUNODER ANGINA PECTORIS MIT on the postinfarct prognosis. Overweight, REGULDERUNODER SAUERSTOFFUTILISATION hypertension, metabolic disturbances etch UND OLEICHtEITIOER KATECHOIAMINDEPRESSION.

231 235 E 11929 (continued) E 11939 (continued) (TREATMENT OF ANGINA PECTORIS WITH rettes per day have a 3 to 5 times greater REGULATION OF OXYGEN UTILIZATION AND incidence of myocardial infarct as com- SIMULTANEOUS DEPRESSION OF CATECHOL- pared with nonsmokers. Nicotine supports AMINES.) Therapiewoche 19(4):169 -72, the development of a thrombus but influ- Jan 22, 19677-ifiRiaTrba. ences only slightly the development of atherosclerosis of coronary arteries. One hundred and thirty-seven patients Stubborn smokers, to avoid inhalation, (92 men, 45 women) were treated with a should switch to cigars or a pipe. Long- sedative (Valocordin) which inhibited the term anticoagulant therapy is useful after liberation of catecholamines or with a termination of the acute stage only in men combination therapy, sedative and nitro- below 55 years of age, that la, about 6 to glycerin (Steno-Valocordin).Of these 20 months after the acute infarct. patients, 58 percent were discharged as very good', 22 percent as 'good', and 14 percent as "satisfactory'.Only 6 E 11944 percent were resistant to therapy. Break- Pirlet, K. and Richter, H. downs were given in the report by age and PHYSIKALISCH-DIATETISCHE THERAPIE BEI aex. The results showed that Valocordin ARTERIELLEN DURCHBLUTUNOSSTORUNOEN DEB and Steno-Valocordin were reliable and SEINE. (PHYSICAL-DIETETIC THERAPY IN effective agents in organic and functional DISTURBANCES OF THE ARTERIAL BLOOD CIR- angina pectoris, stenocardla, and coronary CULATION OF THE LEGS.)Archly fur insufficiency, as well as in the rehabil- Physikalische Thera le 27617171X, itation of patients surviving myocardial Nov-Dec 1968, erman Abs.) infarct. The tolerability was good in all cases and in no case were side-effects A 15-point program which the patient observed. must follow is presented. Provisions of the program are covered in a brochure furnished each patient and emphasized in E11933 succeeding clinic- and office visits. Audier, M. The patient is informed that the disorders LE TRAITEMENT DES ARTERIOPATHIES SENILES are caused by heavy smoking, over- PERIPHERIQUES. (THE TREATMENT OF SENILE nourfahment, metabolic disturbances and PERIPHERAL ARTERIOPATHIES.)Archives lack of exercise, and the causes must be Mediterraneennea de Medecine 45(5):219-42, eliminated or the course of disease will 245-6, Sep-Oct 196H,-FWETE7(Abs.) progressively worsen. The author discusses the nature and treatment of senile peripheral arteri- E 11945 opathie:. The dominant factor in medical Janos, V., Sandor, P., and Eazter, T. treatment is restoration of the cardio- VISCERALIS THROMBANOIITIS OBLITERANS. arterial blood supply. Antithrombosie (VISCERAL THROMBOANOIITIS OBLITERANS.) treatment should always be of short Magyar Sebeszet 22(1):32-5, Feb 1969, duration and, if possible, local. Al- ungarir6-0077) though peripheral disease predominates, this disorder is best viewed as a gener- A case of a rare vieceral form of alized arterial disease. thromboanglitie obliterans diagnosed in vivo, was described. The clinico- fEtEZTEgical relationships and the E 11939 literature data were discussed. Arztliche Praxis. VERHUTUNO ISCHAMISCHER HERZERKRANEUNGEN. (PREVENTION OF ISCHEMIC HEART DISEASES.) E 11949 Arztliche Praxis 21(31)11820, Apr 19, Oberwittler, W. and Dieckhuea, B. 1969, OermErrITs.) OPHTHALMOLODISCHE VND INTERNMEDI- ZINISCHE UNTERSUCHUNGEN AN 226 Prevention of the onset of ischemic KRANKEN MIT UBERSTANDENEM HERZIN- heart disease presents obvious difficul- FARKT. (OPHTHALMOLOGICAL AND IN- ties. Prompt detection and treatment of TERNAL MEDICAL INVESTIGATIONS OF existing ischemia is extremely important, 226 PATIENTS WHO HAVE EXPERIENCED however, in reducing the death toll from MYOCARDIAL INFARCT.) Medizinische this disease.Dietary measures must be Klinik 64(8)s338-44, Feb 21, 1969, instituted to control the caloric, carbo- trliezretn (Abs.) hydrate, and animal fat intake and to reduce cholesteremia. Hypertension and The investigations were conducted diabetes must be controlled, and psychic upon 214 men and 12 women from 24 stress, another risk factor, must be to 64 years of age. Seventy-two of avoided. Smokers of more than 2,.) ciga- the patients manifested arterioacle-

232 2.34 E 11949 (continued) E 11953 ( continued) rotic alterations of the fondue oculi, treatment fov cardiovascular conditions, of which eight had a retinopathy. 62 (42.2 percent) were diagnosed as In three oases there were signs of suffering from chronic cor pulmonale. thrombotic processes of the fundus Almost all were long-time smokers, oculi. A characteristic diabetic consuming from 5 to 30 cigarettes daily. rstinopathy was not found in any of The urgency in providing care for these the patients. The diagnostic value patients in a dispensary was stressed. of the ophthalmological investigation for the evaluation of arteriosclerosis was explained and the significance E 11954 of the ophthalmological findings Hloucal, L. and Dusek, J. for the pathogenesis of arteriosole- EPIDEMIOIGGISCHE STUDIE DER KORON- rosee on the basis of the "nonspecific ARSKIEROSE UND DES HERZINFARKTES. mesenchymal reaction" was discussed. (EPIDEMIOLOGICAL STUDY OF CORONARy SCLEROSIS AND MYOCARDIAL INFARCT.) Wiener Medizinische Wochenechrift E 11952 119(2):27-31, Jan 11, 1969, German Parade, D. (Abs.) COR PULMONALE UND RAUCHEN. (COR PULMONALE AND SMOKING.)Medizinische A remarkable rise in the inci- Klinik 64(2):80-4, Jan 10, 1959, dence of ischemic heart disease was German (Abs.) noted in the internal medicine section of the regional hospital at Strakonice Nicotine abuse in the development in the 1962-1966 5-year period ae of cor pulmonale was investigated in compared with an earlier 1956-1960 177 patients (138 men, 42 women) with period.The increase in myocardial EKG signs of right overloading.Twenty- infarct was :significant (1.5 times). nine patients showed clinically signif- In the last 5-year period the inci- icant signs of a chronic bronchitis dence of ischemic heart disease and with emphysema. Smokers were relatively myocardial infarct was most striking more numerous in this group.The in farmers: four times as high for development of cor pulmonale can have ischemic heart disease and six times different causes with bronchial as high for myocardial infarct. asthma, lung emphysema as well as Remarkably high cholesterol values further parenchymal- and vascular changes were found in patients with ischemit being very important in this respect. heart disease and myocardial infarct Chronic nicotine abuse plays an important in the younger age groups. Smoking role herein. Inhalation of tobacco was seen as one of the important risk smoke in nonindustrial areas is the factors in myocardial infaeot. most important factor, as compared with other forms of air pollution, in the development of cor pulmonale. A E 11972 relatively high coincidence of an Scher, M. obstructive bronchitis with a peptic GEPAHRDUNG VON BETRIERSANGEHORIOEN DURCH ulcer was observed. The number of :smokers HERZ- UND KREISLAUFXRANKHEITEN. with peptic ulcer showing EKG indications (ENDANGERMENT OF PLANT EMPLOYEES of right overloading of the heart was BY CARDIOVASCULAR DISEASES.) also relatively high. Zeitschrift fur Praventivmedizin f41e):109-12 7kr-Apr 1969, German (Abs.) E 11953 Rentsch, H. J. Hypoxic heart diseases are the most DAS COR ?UR:MALE CHRONICUM IM HOHEREN frequent causes of death in man above the LEBENSALTER. (CHRONIC COE PULMONALE age of forty years and are caused chiefly IN OLDER PEOPLE.) Zeitschrift fur through a sclerosis of the coronary Arztliche Fortbildun, 62{207:11M33, veesele. Cholesteremie, hypertension, Cot 15, 19E8, Oerman (Abs.) overweight, and cigarette smoking represent an elevated risk for coronary heart General data in the symptomatology disease.The risk factors were deter- and diagnosis of chronic cor pulmonale mined in 1100 workers. An attempt was were given. The diagnostic possibil- made to influence the emoking and nutri- ities in small hospitals were discussed. tional habits by health education in 50 The author also reported his own obser- percent of the workers who exhibited 2 or vations on the male patients of the more of the risk factors.A significant hospital who were treated for this loss of weight was observed in several disorder in 19661 of 146 men undergoing men of the teat group. An improvement could also be observed in lowering the

233 E 11972 (continued) E 12013 blood pressure in several men of the Mazunder, H. C. test group but the smoking habits were MYOCARDIAL INFARCTION AND TOBACCO AND not essentially altered. ALCOHOL HABITS.Indian Medical Forum 20(3)09-102, Mar -lib

E 11974 Spengler, C. H. and Scher, M. E 12021 PROSPECTIVE SOZIALMEDIZINISCHE Sackett, D. L. STUDIE IN EINEM INDUSTRIELLEN CIOARLTUS, ALCOHOL, HOSPITALS, AND GROSSEETRIEB. (PROSPECTIVE ATHEROGENESIS. American Heart Journal SOCIAL MEDICINE STUDY IN A 78(3)1423-4, Sep 1969. LARGE INDUSTRIAL PLANT.) Zeitschrift fur Preventivmedinin 14(2):103-7,-Mgr-Apr 1988, E 12027 German (Abs.) Jan, P. and Beaumont, J. L. PHENOMENE THROMBO-HEMORRAGIQUE DEOLENCHE A 5-year study was initiated in 1968 PAR L'ADRENALINE ET AL NICOTINE. on'900 male employees, 30-59 years old, (THROMPIOHEMORRHAGIC PHENOMENON CAUSED of Sulzer AO to learn whether risk fac- BY ADRENALINE AND NICOTINE.) Archives tors for cardiovascular diseases could dee Maladies du Coeur et des VITTAFEW be reduced.The study included the known TrrsUFT:77:76-3; T760711Wrich(Abe.) risk factors, smoking, blood pressure, overweight, and cholesterol, to which A thrombohemorrhagic phenomenon was were added 14 psychosocial "stress" ques- obtained in the rat by using carrageenin tions and 5 Reeder questions. Prelimi- and noradrenline then by replacing the nary results were reported: correlation latter by nicotine in a second series of between blood pressure and overweight experiments. Finally, the phenomenon and between overweight and cholesterol; could be reproduced by a prolonged no confirmation of an expected negative treatment with subliminal doses of both correlation between smoking and over- carrageenin and nicotine. weight; a significant correlation between the "stress" questions and the known risk factors not found; supposedly, no nega- E 12029 tive correlation between sport and the Garrison, n. E. known risk factors; no correlation be- EPIDEMIOLOGY OF CORONARY HEART DISEASE. tween overweight and psychosocial :stress, Journal of the Medical Aasociation of psychosocial stress and the Reeder ,Zritr7-1--It agir(7)r331"477nr=g7:- questions, and between blood pressure and stress; negative correlation between hard sports, Raab teat, and vital capacity E 12031 with overweight. Padmavati, S. and Sandhu, I. INCIDENCE OF CORONARY ARTERY DISEASE IN DELHI PROM MEDICO-LEGAL AUTOPSIES. E 11983 Indian Journal of Medical Research Oliver, M. P. 57(3774M7671417 1969. IS APOINA PREVENTABLE?Res Medica (Special Issue):43-8, ApF-1-9577--- E 12038 Dubrulle, P. E 11990 LE DEPISTAGE PRECOCE DE L'ATHEROSCLEROSE. Ratcliffe, H. L., Luginbuhl, H., Schnarr, (EARLY DETECTION OF ATHEROSCLEROSIS.) W. R., and Chacko, K. Cahiers de Medecine Interprofessionnelle CORONARY ARTERIOSCLEROSIS IN SWINE: 7(32)t39=T47-177MPrench "Abe.) EVIDENCE OF A RELATION TO BEHAVIOR. Journal of Comparative and Physiological The factors Involved in the develop- TiriTMTogyt8(3)1386=947u1 19 ment of atherosclerosis were reviewei. The value of various diagnostic methods, as well as the particular techniques of E 12001 the Comite pour le Developpement de la Lang, D. M. and Ohrt, D. K. Medecine du Travail de Lille, were then THE INTERRELATIONSHIP OF FAT, discussed. Subjects with clinical, pars- CARBOHYDRATE AND ATHEROSCLEROSIS. clinical, or biological injury were South Dakota Journal of Medicine referred to their personal physicians for Mr:7r-47 Jul 1969. therapeutic action.Emotional factors, by themselves, were deemed insufficient to entirely condition atherosclerosis but

236 12036 (continued) E 12042 (continued) they were believed capable of acceler- ating natural processes. Tobacco abuse Potential, subclinical, vascular ( favored manifestations of atherosclerosis insufficiency, conditioned by the in certain 011108 or, at least, caused a narrowing and hardening of the arterio- more rapid evolution of the diaease. sclerotic artery can reach the level of Thio action of tobacco was especially clinical manifestation when one of the harmful in arteritis of the lower limbs. following situations occurs' Extension of the lesions to now vascular areas by per- sistence of the . therogenic factors; com- 12039 plications of already-existing lesions; Jouve, A. and participation of other hemodynamic LES ARTERIOPATHIES DES MEMBRES. and vascular factors. Each of these, as (ARTERIOPATHIES OP THE LIMBS.) well as the role of such pathogenic Oueet Medical 22(4i:31S-22, Feb 25, factore as diet, diabetes, arterial rim ITiEret(Abs. hypertension, obesity, psychic stress and heavy smoking, was diecussed. It was The evolution of arterial diseases of noted that one year after the discontin- the limbs, current diagnostic techniques, uance of smoking, the danger of coronary and current medical and surgical treat- accidents in atheroeclerosis was greatly ments were discussed in a T V broadcast. reduced, regardless of the duration of Early diagnosis and preventive measure the smoking habit. were stressed in order to forestall advanced stages of the disease.Smoking is prohibited in patients with t' dis- E 12043 ease since tobacco is recognized - In Gottstein, U. important factor in its development and INTERNE THERVIE DER ALTERNSPROZESSE DES the disease rarely appears in individuals UHIRES UND SEINER GEFASSE. (INTERNAL below forty years of age without a high THERAPY OF THE AGING PROCESSES OF THE consumption of tobacco. BRAIN AND ITS BLOOD VESSELS.)Wiener Klinische Wochenechrift 8124)arr=g7 mirrsrm9, German (Abs. 12011 Barrillon, A., Binet, J.-P., de Gennee, The causes and therapy of the aging J.-L., Hazen, E., and Lenegre, J. procesces were described. It was LE TRAITEMENT DE FOND DE L'ATHEROSCLEROSE emphasized that arteriosclerosis of CORARIENNE.ON (BASIC TREAMENT OF CORO- the brain we: a consequence of injurious NARYATEEROSCLE(OSIS.) FrTeeseMedicate influences during the lifetime of the 77(28):1C93-6, Jun 7, 196r7inTegartni.) individual and became manifest with age. The factors which favored the A. Barrillon discussed necessary development of arteriosclerosis were therapeutic measures such as caloric listed au nicotine abuse, arterial intake and regimen, suppression of tobac- hypertension, diabetes mellitus, fat co, treatment of arterial hypertension, metabolism disturbances, hypothyroidism, hypocholesteremic drugs, living habite, gout, and inflammatory hypersensitive and anticoagulant treatments. The con- reactions. ventional drugs for angina pectoris were also mentioned.E. Hazen discussed the possibilites of surgery in angina E 12014 pectoris: J. Lenegre was more sceptical Ducloux, G. of the role of surgery today, considering ACQUISITIONS RECEN TES DANS LE DIAGNOSTIC it of possible future value only if the ET LE TRAITEMENT DE L'ANOINE DE POITRINE. surgical risk:: became acceptable. J. L. (RECENT ACQUISITIONS IN THE DIAGNOSIS AND de Gennee discussed three types of TREATMENT OF ANGINA PECTORIS. Lille metabolic troubles (lipidic, hydrocarbon Medical 14(4):476-87, Apr 1969, and uric) which must be futher researched. frer-M(Aba.) He also discussed necessary dietetic measures and drug treatments. Modern techniques for the diagnosis and treatment of angina pectoris caused by coronary atherosclerosis were reviewed. E 12042 The diagnostic methods include inter- Maenatta, 0,, Dadoni, L. 0., and Pardal, C. rogation for ascertaining risk factors, FACTORES DESENCADENANTES DE LOS clinical examination, electrocardiogram, ACCIDENTES VASCULARES AGUDOS DE LA mechanogram, coronary arteriography and AIEROSCLEROSIS. (CAUSATIVE FACTORS OF metabolic and immunological studies. ACUTE yASCVIAR ACCIDENTS OF ATHEROSCLE- Medical treatments include method:: for ROSIS.) ?refse Medics .,rgentina 5§(2): medical vascularization, electrical stim- 49-72, Ke1771171;17-gpanish (Abs.) ulation of the carotid sinus, surgery and preventive medicine.

235 R39 E 12060 E 12082 (continued) Harley, R. A., Friedman, P. J., Seldana, Chronic Obstructive Lung Disease. M., Liebow, A. A., and Carrington, C. B. U. S. Department of Health, Education, SEQUENTIAL DEVELOPMENT OF LESIONS IN and Welfare, Public Health Service, EXPERIMENTAL EXTREME PULMONARY Washington, D.C., Public Health Service HYPERTENSION. Ini Proceedings of the Publication No. 1787, 1968, pp. 163-76. Eleventh Aspen Emphysema Conference, Aspen, Colorado, Jun 12-15, 1968, Current Research in Chronic Respiratory E 12083 Disease. U. S. Department of Health, Kimbel, P., Nagano, M., Stein, M., and Education, and Welfare. Public Health Nunez, L. E. Service, Washington, D.C., Fublic Health THE EFFECTS OF PULMONARY EMBOLISM ON Service Publication No. 1879, 1969, pp. PULMONARY CAPILLARY BLOODFLOW. 117-20. In: Proceedings of the Tenth Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Current Research in E 12061 Chronic Obstructive Lung Disease. Grover, R. F., Alexander, J. K., and U. S. Department of Health, Education, Hartley, L. H. and Welfare, Public Health Service, MYOCARDIAL FUNCTION IN CCR PULMONALE. Washingon, D.C., Public Health Service In: Proceedinge of the Eleventh Aspen Publication No. 1787, 1968, pp. 177-90. Emphysema Conference, Aspen, Colorado, Jun 12-15, 1968, Current Research in E 12110 Chronic Respiratory Disease. U. S. Department of Health, Education, and Heyden, S., Heyman, A., and Camplong, L. Welfare, Public Health Service, MCRTALITY PATTERNS AMONG PARENTS OF Washington, D.C., Public Health PATIENTS WITH ATHEROSCLEROTIC CEREBROVASCULAR DISEASE. Journal Service Publication No. 1879, 1969, of Chronic Deseases 22(2):TOr.707 pp. 121-8.

E 12062 Rao, B. S., Cohn, K. E., Eldridge, F. E., E 12111 and Hancock, E. W. Caffrey, B. LEFT VENTRICULAR FAILURE SECONDARY TO BEHAVIOR PATTERNS AND PERSONALITY CHRONIC PULMONARY DISEASE. In: Proceed- CHARACTERISTICS RELATED TO PREVALENCE ings of the Eleventh Aspen Emphysema RATES OF CORONARY HEART DISEASE IN Journal of Chronic Conference, Aspen, Colorado, Jun 12-15, AMERICAN MONKS. 1968, Current Research in Chronic Reapi- Disease! 22(2)193:1717-7ura697--- ratory Disease. U. S. Department of Health, Education, and Welfare, Public Health Service, Washington, D.C., Public E 12115 Health Service Publication No. 1879, Beg, M. A., Siddiqui, M.K., Ahmed, N., 1969, pp. 129 -34. Abbasi, A. S., and Syed, S. A. ATHEROSCLEROSIS IN KARACHI--A RETROSPEC- TIVE STUDY OF THE CLINICAL PATTERN OF E 12080 CORONARY HEART DISEASE IN CARDIAC Most.yn, E. M. and Luft, U. C. ADMISSIONS. Journal of the Pakistan ALVEOLAR-ARTERIAL GRADIENTS FOR OXYGEN Medical Association 1811117412-20, Nov AND CARBON DIOXIDE IN PULMONARY rin737-- EMBOLIZATION. In: Proceedinge of the Tenth Aspen Emphysema Conference, Aspen, Colorado, Jun 7-10, 1967, Cur- rent Research in Chronic Obstructive E 12157 Lung Disease. U. S. Department of Paffenbarger, R. S., Jr., Thorne, M. C., Health, Education, and Welfare, Public and Wing, A. L. Health Service, Washington, D.C., Public CHRONIC DISEASE IN FORMER COLLEGE Health Service Publication No. 1787, STUDENTS. VIII. Characteristics in 1968, pp. 155-44. Youth Predisposing to Hypertension in Later Years. American Journal of Epidemiology 811(1):25-52, 1968. E 12082 Dunnill, M. S., Allison, P. R., Marshall, R., and Morrell, M. T. E 12142 PULMONARY EMBOLISM. Feinleib, M., Kennel, W. B., and Parrish, In Proceedings of the Tenth Aspen H. M. Emphysema Conference, Aspen, Colorado, CORONARY ATHEROSCLEROSIS IN WOMEN Jun 7-10, 1967, Current Research in CASTRATED PREMENOPAUSALLYIREPLY TO

64 E 12161 E 12142 (continued) American Walker, A. R. P. DRS. FEINLEIB AND KANNEL. CAN EXPECTATION OF LIFE 1N WESTERN Journal of Obstetrics and GYFFEBT7T57 POPULATIONS BE INCREASED BY CHANGES 104(7)s111587-13;,irl",77769. IN DDT AND MANNER OF LIFE? South Africrm Medical Journal 43(257!7T -75, E 12143 NEM, 1969. Kritchevsky, D. EXPERIMENTAL ATHEROSCLEROSIS IN PRIMATES Annals of the New E 12172 AND OTHER SPECIES. Malden, W. K. York Academy of ScieriCe17762(1770737 INFLUENCE OF DIET ON CARDIOVASCULAR 7U--3,1964. MORBIDITY. Journal of th,., American Medical Womeglirffoareilat 8(24): g3771r,AugorT. E 12144 Gresham, G. A. and Howard, A. N. EXPERIMENTAL ATHEROSCLEROSIS IN BABOONS. E 12185 Annals of the New York Academy of Djordjevic, B. S., Josipovic, V., Straser, SErgrcer1670.77797MJul 3, 1769. T., Nedeljkovic, S., Lambic, I., Balog, B., StojAnovic, 0., Macarol, V., Simic, V., Simic, A., Slavkovic, V., Milutinovic, E 12145 P., Kline, L., and Jovanovic, M. Eggen, D. A., Strong, J. P., and Newman, OPP-01W W. P. 11P44 PE3YTITATOrINNANWAE1114,774401301141E samcno Y TPWPA3A44,11T OXV116414}E ITYTE Y Un6PCO. EXPERIMENTAL ATHEROSCLEROSIS IN PRIMATES: PRVI RFZULTATI PROUCAVANJA EPIDEMIOLOGIJE A COMPARISON OF SELECTED SPECKS. Annals KORONARNE BOLESTI U TRI RAZIACITE of the New York Acade of Sciences POPULACIONE GRUPE U SRBIJI. (FIRST 1T21TT:1715-77-7u , 1 677 RESULTS OF EPIDEMIOLOGICAL RESEARCH OF CORONARY DISEASE IN THREE DIFFERENT POPULATION GROUPS IN SERBIA.) Glasi E 12146 S aka Akademi a Nauka 1 umetnoniT Clarkson, T. B., Lofland, H. B., Bullock, e ciran5 Nauka 27271): B. C., Lehner, N. D. M., St. Clair, R., serbo-Croat irrirAba. and Prichard, R. W. ATHEROSCLEROSIS IN SOME SPECIES OF NEW Results were given of a prospective WORLD MONKEYS. Annals of the New York study of 3 different groups, (1) farmers Academy of ScienFirinTr)Tr63797ZUTS, of Velika Krona, i2) factory workers of 1969. Zrenjauin, and (3professors of Belgrade University. Differences between the professors and the farmers were clear and E 12147 significant regarding the incidence of Stout, C. and Oroover, M. E., Jr. coronary disease, 74 among professors and SPONTANEOUS VERSUS EXPERIMENTAL only 30 among farmera. Differences in ATHEROSCLEROSIS. Annals of the New cholesterol level were also clear and York Academy of ScririErgnTrT:81T98, significant, very high in the professor 77.11-3, 1964. group and much lower in the other, especially farmer, groups. The Belgrade University group also had greater E 12149 statistically significant syatolic and Frederiksen, H., Ravenholt, R. T., and diastolic hypertension in comparison Bush, R. D. especially with the farmer group but ORAL CONTRACEPTIVES AND THROMBOEMBOLIC also in comparison with the factory DISEASE. British Medical Journal 3 (5669):52977747907---- workers.

E 12186 E 12154 Bruggemann, W. Washington University School of Medicine, ACTION OEOEN DEN HERZINFARKT. (ACTION Department of Medicine, St. Louis, AGAINST MYOCARDIAL INFARCT.) Thera pis Missouri. der Gegenwart 108(1):75-6, 76- , - , CORONARY HEART DISEASE AND RHEUMATIC 857, Jan 19;9, German (Abs.) FEVER. In: Manual of Medical Therapeutica, 19th Edition, Boston, AltAough many statistics have been Little, Brown and Co, 1969, pp. 77-94. reported recently, the epidemiology of coronary infarcts cannot be evaluated without the aid of animal experiments.

237 241 E 12186 (continued) E 12188 (continued) In the U.S., the following factors may predispose people to cardiac infarct: Christopher Bjerkelund writes to vascular and metabolic diseases, criticize Erling Kristensen. Bjerkelund adipoeity, increased blood fat levels, accuses Kristensen of confusing in his high blood pressure, smoking and statistical evaluations the term nicotine intake in other forms, lack of prevalence (number of sick persons at a physical exerciee, psychic stress, certain time divided by the number of disturbancee in the accustomed rhythm of persons in the population) with the term life, and decreased glucose tolerance. incidence (number of new cases of disease Based on this knowledge, in Western per unit of time, divided by the number Germany a "Kneippbund" was formed which of persons in the population).Therefore advocated a natural diet regime and a he reiterates that Kristensenis notions reatrictlon of nicotine intake. Excesses about primary and secondary prophylaxis and fanaticism are to be avoided and are erroneous, particularly in regard to membera will not bathe in an open river the number of caries between 1935 and 1961 although their program calls for daily in Norway. exposure to cold water. Smoking is not completely abolished. The Kneipp program takes into account age and E 12190 occupation. If their system leads to Jensen, D. and Zeiner-Henriksen, T. stress after giving up smoking, then the MORBIDITZTEN AV CORONARE HJERTESYKDOMMER desired effect is not obtained.This I NORGE DELYST VED ET TRYODEKASSE- program was seen to reduce heart MATERIALE. (MORBIDITY DUE TO CORONARY infarcts. A counterpart of this HEART DISEASE IN NORWAY, BASED ON HEALTH society in New York is the "anti- INSURANCE STATISTICS Tidsekrift for den coronary club" which is however too Norske Leegeforening 89(2):73-6,-Min75, small to put forth valid conclusions. 1969, Norwegian A statistical evaluation on coronary E 12187 heart disease in several Norwegian cities Lukl, P. for 1965 is presented.Factors involved SEKUNDARE PREVENTION DER ISCHAMISCHEN included the reasons persons retired and HERZERKRANKUNGEN. (SECONDARY PREVENTION requested compensation for heart diseaae, CF ISCREMIC HEART DISEASBS.)Deutsches and hospital treatment. Bergen and Oslo, Medianisches Journal 20M:29=3373E7 as well as other cities in Norway 5, 1969, camel-715M accounted for a greater incidence in men between 60 and 69 years of Lge. In women, prevention of decreased blood the incidence of coronary heart disease supply is based on a proper, balanced was greater after 70 years of age. Once diet, the avoidance or stream, and admitted to a hospital, men tend to stay reduction of tobacco consumption. It longer than women before they are dis- has been definitely proven that persons charged. In the 30-49 age group, men show smoking more than 20 cigarettes a day fewer cases of this disaase; women are show 3 to 5 times higher risk of an afflicted with this disease only rarely. infarct of the myocardium. Arterial hypertension can also lead to these diseases; however, drugs used to cure E 12191 them have undesirable side effects. van Proosdij, C. At tha present time it appears that TABAKSROOK EN KOOLMONOXYDE. (TOBACCO methyldopa (Dopegyt) is indicated as the SMOKE AND CARBON MONOXIDE.) Nederlande drug of choice. If rehabilitation is Ti schrift voor Geneeskunde 112(15):699- conducted correctly, about 50 percent of , pr ,7rgre, Dutch (Abs.) the persons afflicted can return to work, but only 20 percent will actually The harmful effects of carbon monoxide be free of complaints. in the human organism were reviewed. Smoking is responsible for higher CO levels in the blood than that resulting from air E 12188 pollution from %utomobile exhalst gases. Bjerkelund, C. Mainstream cigar smoke contains a higher CORONARSYKDOMMENES EPIDEMIOLOOI. percentage of CO than cigarette smoke, but (EPIDEMIOLOGY OF CORONARY DISEASE.) cigar smoke customarily is not inhaled. A Tidsskrift for den Norske Lee eforenln CO level of 0.2 to 0.8 volume percent in 69(2)11019-115, JEK-157-13r4, orweg an the blood can correspond to a hemozlobin (Abe.) saturation of 4 to 5 percent. The usual

238 E 12191 (continued) E 12200(continued) CO-Hb levels in the blood of smokers case of cigarettes, furthermore, carbon generally cause no visible harmful monoxide poisoning becomes superimposed effects in healthy smokers but the over the damage done by nicotine alone. performance of athletes as well as performance at high altitudes can be affected. Dark-adaptation is also E 12206 affected. Carbon monoxide has a harm- Wahl, P. and Hahn, U. ful e re^ nn the respiratory organs as ZUR WIRKVNG DES RAUCHENS AUF DIE FREIEN well as on they organs with a reduced FETTSAUREN DES SERUMS. (EFFECT OF capacity for oxyeen transport. The SMOKING ON THE FREE PATTY ACIDS OF THE possibility that effect of nicotine SERUM.)Verhandlungen der Deutschen on coronary sclerosis and Buerger's Oesellscharr-Ur Innere-Malan 74:953-6, disease may be potentiated by carbon IrgE75E"Inan 75'87 monoxide cannot be excluded. An investigation of smoking effects was undertaken with 29 healthy, graduate B 12192 students of both sexes, from 22 to 59 Forster, G. years of age. Twenty-one were tested ZUR KLINIK UND EINTEILUNG DER when fasting, the rest after breakfast. HYPERLIPIDAMIEN. (ON THE CLINIC ANp Seven persona were non-smokers, and the CLASSIFICATION OP HYPERLIPO/DEMIAS.) rest moderate- to-heavy smokers. After Medizinische Welt i28)11553-6, Jul the first blood sample wee collected, 1969, German rra. each person was made to smoke a cigarette and inhale deeply.There was a time The incidence and significance of the lapse of 4 to 8 minutes until the next different for of hyperlipoidemia were blood sample could be taken.The time briefly described.According to Freder- could not be reduced because the non- ickson the five different types of pri- smokers smoked so slowly.Results are mary or essential hyperlipoldemia can be not conclusive since each individual differentiated on the basis of lipoid reacts differently.After smoking the electrophoreals, glucose tolerance and assay of free fatty acids in the serum the dependence of fat or carbohydrate in will change, but it cannot be concluded the diet.This division today makes that the increase of these acids due to possible a differentiated dietetic or smoking affects the atherogenesis. drug therapy.

E 12207 E 12200 Oettel, H. Robin, E., Ravens, K. 0., and Bing, R. J. TOXISCHE OEFASSSCHADEN UND DURCH- DIE WIRKUNO VON ALKOHOL, NIKOTIN UND BLUTUNOSSTORUNOEN. (TOXIC VASCULAR ZIGARETTENRAUCHEN AUF DAS HERZ. (THE DAMAGE AND DISTURBANCES OP BLOOD CIR- EFFECT OP ALCOHOL, NICOTINE AND CULATION.) Hippokrates 40i8):285-95, CIOARETTE SMOKING ON THE HEART.) Apr 30, 1969, German labs. Deutsche: Medizinisches Journal 20(1): 19-29, an 5,1969, German s.) A ten-point program is presented for preventing blood vessel dieeasee, based the various effects of tobacco and upon complete prohibition of tobacco in alcohol on the heart are evaluated in any form.A toxic action may be brought the light of 133 literature reports. about in the human organism by a spe- Both alcohol and nicotine act upon the cified chemical formula, or by fear. Pear metabolism of the myocardium and upon Is classified as an occupational hazard if the hemodynamics of the coronary the stress' under which a person works arteries. The actions are differential causes such fear.True chemical since alcohol in the course of its poisoning (e.g., by mercury, asbestos, metabolism will remove available oxygen halogenated hydrocarbons, benzoquinone) from tissues and in this way might 16 actually rare, but diseases produced create a shortage of nicotinamide- by chemical dusts are much more common. adenine dlnucleotide (NAD), whereas Walls of the vessels might be damaged, nicotine acts as such in the or the vessels might become enlarged in unmetabolized state and the products of the presence of such toxic agents as its metabolism also create damage. A duet. Alcoholic beverages will aggravate difference le seen if nicotine enters such diseases.Nicotine and tobacco in the body on detour over cigars or all forms are really the main culprits, cigarettes, and in the case of ciga- and they account for diseases more often rettes, nicotine shows an enhanced than the other causative agents ability to form a thrombus, which is mentioned.A difference is seen in those also favored by pure nicotine. In the smoking cigars P-' those smoking

239 445 E 12207 (continued) E 12213 (continued) cigarettes. The cigar smoker is not Bo arteriosclerosis. In cams of hormone heavily affected by these diaeases be- imbalance, it must be taken into account cause he swallows a considerable amount that some hormones (thymus hormone) in- of the nicotine which reaches the liver crease mesenchymatic metabolism, whereas and is rendered harmless. Cigarette others (ACTH) lower it. Predisposition to smoking will aggravate vessel damage arteriosclerosis may result from the use already existing due to other causes, of nicotine and other stimulants, lack of and migraine attacks will occur with exercise, social pressures and stress, greater severity and frequency in faulty dietary habits, and overnutrition. smokers and those who started to smoke Adiposity and alimentary hyperlipidemia after the disease was established. Even all make a person prone to this syndrome. so-called passive smoking is a hazard There is actually no strict boundary since a nonsmoker sitting all day in an between prophylaxis and long-term therapy. office with smokers will show a higher It must be ascertained why the metabolism incidence due to the contaminated air of fats is disturbed, dietary habits must he is forced to breathe. be regulated, and druga to lower the lipoid level must be administered. These drugs will impede the synthesis of lipids, E 12209 prevent their migration out of the fatty Kaindl, F. tissue, prevent the resorption of fats, DIAGNOSTIK UND THERAPIE ARTERIELLER and remove the lipoproteins from the VERSCHLUSSKRANKBEITEN. (DIAGNOSIS plasma. More recently drugs were admin- AND THERAPY OF ARTERIAL OCCLUSION istered to lower the lipiod level, inhibit DISEASES.) Wiener Medizinieche unspecific mesenchymatic reactions, and Wochenschrift 119(111):333 -4Q7 Fay 3, increase the blood flow through the 1969, German (Abs.) tissues. The patient is cautioned to quit smoking, not overeat, avoid stress, and do Arterial-blocking diseases are those physical exercise. Long-term drug therapy which are noted in the extremities when will lower the lipid level, act upon blood patients, complaints includes pain, flow through tissues, affect pallor, weakness, pareathesia, and capillarization and repair mesenchymatic paralysis.Diagnostic tools cover damage. vein-filling times, oacillometry, auscultation of vessels, plethymography, diet, exercise, and treatment with E 12219 anticoagulants. As the calm indicate, Hauffe, Ch. individual precautions must be taken FORTSCHRITTE IN DER SPORTMEDIZIN. and thus a ring of foam rubber might (ADVANCES IN SPORTS MEDICINE.) be indicated to prevent pressure Arztliche Praxis 21(11)1620-1, necroses from occurring. 625-6, Feb 8, 1969, Berman (Abs.)

(Abstract of papers presented at the E 12213 meeting of West German sport physicians, Iunge-Hulaing, O. December 13-15, 1968).Cardiologic MOGLICHKEITEN DER PROPHYLAXE W) Presymptomatic diagnoals LANGZEITTHERAPIE PATERIOSKLEROTISCHER EKIWILTIffissed to the extent that it is PROzESSE. (POSSIBILITIES OF PROPHY- easier to prevent cardiac disturbances LAXIS AND LONG-TER/I THERAPY OF ARTERIO- now. Penicillin prophylaxis is used for SCIEROTI: PROCESSES.) Therapiewoche 19 rheumatic heart disease, and it is (2)16441, Jan 8, 1969, German (Aba.) now known how an atrium septum defect can be compensated for, although Prophylaxis of an arteriosclerotic coronary acleroais remains difficult to procesa is generally based on preventing diagnose It is mentioned that arterial mesenchymal damage to the walls of pressure may change by 50 ram in 10 seconds vessels. A schedule ie presented on and so the ordinary sphygmomanometer is the manner 6 physician may examine a worthless in detecting this symptom. patient suapected of having arterioacler- Circulation teat and size of heart: A oats. It conaists of anamnesia, clinical EIFFMatory function leading to the symptoms, findings in clinical diagnosis of vegetative dystonia is diagnostics, diagnostic steps to be taken, described. The heart may show shapes and and laboratory diagnostics, If sizes different from the accepted norm, hyperlipidemia is found, it moa be 'nd the diaphragm may change its position, ascertained whether it ie primary or intrathoracal processes arise, such secondary. Certain diseaaea (e.g., i tumors, exudates, pneumothorax, or hypertension, metabolic disturbances, ._telectaels of the lunge. In the toxic processes, and hormonal distur- left-side of the heart, since a greater bance) predispose a patient to rasistence is seen, a certain aorta

240 2.44 E 12219 (continued) E 12222 (continued) configuration will arise as time Wiener Klinieche Wochenschrift 81(25): progresses. Peychic conditionin : A Igr=r7 Jun 20, 1955, German (Abs. person engaged in sports w s ow the best performance only if both body and Medical re-evaluation has been made in psyche are healthy and in full harmony. regard to vessel enlargement therapy for Adaptation: This is now defined as a arteriosclerosia.Vessel enlargement shorE'-duration adjustment reaction with- treatment currently depends on the out any preceding exercise. specific factors causing the malady. Physiotherapy: This is used in Susceptibility to this affliction is traumatology and accident - medicine. based on hyperlipidemia, hypertension, Three groups of instruments are metabolism affected by diabetes, employed: those which heat tissues with cigarette consumption, obesity, in- high-frequency alternating currents; sufficient physical exercise, stress in those supplying irritation currents, family environment, physical constitu- or low-frequency instruments, causing tion, personality type, and worry over muscle contraction; and instruments family welfare.Depending on which creating galvanization, bringing about causative agent prevails, the method of hyperemia, loosening of membranes, treatment will change from one case to resorption, and migration of ions. another. However, it must be stated that, in general, absolute prohibition of smoking, or at least great reatriction E 12221 thereof, must be part of any therapy Lichtlen P. and Baumann, P. C. method. ZUR THLRAPIE UND DIAGNOSE DER ANGINA PECTORIS. (THERAPY AND DIAGNOSIS OF ANGINA PECTORIS.) Praxis 58(5):135-44, E 12223 Feb 4, 1S'69, Germanng7) Hedberg, E. and Lindberg, J. VENTRIKELSEPTUMRUPTUR SOM KOMPLIKATION The pathophysiology, diagnosites, and TILL HJART/NFARKT. (RUPTURE OF THE treatment of angina pectoris are VENTRICULAR SEPTUM AS A COMPLICATION discussed. Of the treatment methods, OF MYOCARDIAL INFARCT.) Lakartidningen nitroglycerin drugs are atill considered 66(2):98-102, Jan 8, 1969, Swedish (x s.) the best agent and a number of ways to improve treatment with it are now known. Three cease of cardiac infarct are For example, Inderal (Propanolol) will described: a 62-year-old manual exert a synergistic effect on laborer, a 75-year-old pensioned factory nitroglycerin; in addition, according to worker, and a 62-year-old painter who the individual case, the patient should had been engaged In hie occupation for be digitalized, and anticoagulants given 40 years. Four types of ruptures are to reduce the risk of infarct. known to occur in cardiao infarct, but Cholesterol-lowering substancea should the cases described are considered a fifth be administered with great care as they poeeibility. All patients were smokers, shot side reactions and might potentiate but their anamnese showed such a variety the action of anticoagulants in an of maladies affecting the heart earlier undesirable manner. Nicotine in any form that no conclusions can be drawn as to should be forbidden, although it Whether tobacco did or did not exert an actually has a slight effect on angina influence on the infarct. pectoris and sometimes induces a coronaryspastic effect. Loss of weight le very important, and patients should E 12225 undertake Physical exercise until their Krysa, I. pain threshold is reached. Coronary TABAKOVA SRDECNI ANGINA. (TOBACCO- operations should be resorted to in INDUCED ANGINA PECTORIS.) Vnitrni cases where the various drugs show Lekarstvi 12:492-6, May 196b, Czech absolutely no ealutory effect. Implantation of Arteria mann. int. or Pm= a vein patch grart are mentioned. A literature review of 35 references Patience is of the greatest importance and is presented on angina pectoris induced thm physician should endeavor to keep by tobacco smoking.Factors mentioned hip patients in good spirits. are hypoxia, blood pressure alterations, changes in blood volume, tobacco allergy in vascular diseases, and oxygen E 12222 utilization in laboratory animals. In Siedck, H. cases of angina, electrocardiograms may GEZIERELLE THERAPIE DER ARTERIOSKLEROSE. show normal values, but treatment with (=MAL THERAPY OF ARTERIOSCLEROSIS.) glycerol trinitrate (nitroglycerin) does

241 245 E 12225 (continued) E 12245 not give any relief.Nicotine is said Seltzer, C. C. to induce stenocardia, disturbance of OVERWEIGHT AND OBESITY. The Associated the cardiac rhythm, palpitation, cold Cardiovascular Risk. Minnesota Medicine extremities, tremor," nausea, and 52(8):1265 -70, Aug 1969 prostration.In a differential diagnosis, care must be taken not to confuse the symptoms with ischemia of the heart, E 12246 but in this instance the EKG can be used Doyle, J. T. as a guide.Tobacco angina per se is CIGARETTE SMOKING. The Associated not too common, and 1 percenE-Uf-ill Cardiovascular Risk. Minnesota anginas encountered are primarily Medicine 52(8)0311-13, Aug 1969. caused by tobacco.The mechanism of this type of angina ie fairly complicated because nicotine presumably causes an E 12247 allergic phenomenon leading to many Epstein, F. H. other types of complications, starting ELEVATED BLOOD SUGAR. The Associated with a simple migraine headache, Cardiovascular Risk. Minnesota Medicine resulting in a greater load upon the 52(8):1271-4, Aug 1969. heart. Catecholamine is one metabolism product of tobacco known affect the heart. This type of angina may be E 12248 classified as a typical cardiac Christakis, O. insufficiency which becomes permanent. OBESITY AND NUTRITION EDUCATION. Community Approach to Prevention of Coronary Heart Disease. Minnesota E 12228 Medicine 52(6):1279-82, Aug 1969. Aronow, W. S. and Swanson, A. J. THE'EFFECT OF LOW-NICOTINE CIGARETTES ON ANGINA PECTORIS.Annals of Internal E 12251 Medicine 71(3)1599 -60r7Sep iT69. Bruno, M. S. and Ober, W. B. (Editors) PROGRESSIVE UREMIA AND HEPATIC INSUF- FICIENCY.New York State Journal of E 12238 Medicine 69117)173417977er1, 19607 Astrup, P. EFFECTS OF HYPDXIA AND OF CARBON MONOXIDE EXPOSURES ON EXPERIMENTAL E 12252 ATHEROSCLEROS;S.Annals of Internal Lloyd, T. C. Medicine 71(2):426:77-X747907----- HYPDXIC PULMONARY VASOCONSTRICTION: ROLE OF PERIVASCULAR TISSUE. Journal of Applied Physiology 25(5):560-5, Nov 1968. E 12241 Paul, O. PHYSICAL INACTIVITY. The Associated E 12254 Cardiovascular Risk. Minnesota Edmonds, J. H. Medicine 52(8):1327-31, Aug 1969. EXERCISE AND THE PREVENTION OF CORONARY HEART DISEASE. Journal of the Medical Association of 0.17i01718( 97117-g5 E 12243 1707-- Wells, R. THE EPIDEMIOLOGY OF ISCHAEMIC HEART DISEASE IN AUSTRALIA. Medical Journal E 12263 of Australia 2(2)009-0717I71, 1969. Kennel, W. B., Castelli, W. P., and McNamara, p. M. SERUM LIPID FRACTIONS AND RISK OF E 12244 CORONARY HEART DISEASE. The Framingham Turpeinen, 0., Miettinen, M., Karvonen, Study. Minnesota Medicine 52(8):1225- M. J., Roine, P., Pekkarinen, M., 30, Aug rw7---- Lehtosuo, E. J. and Alivirta, P. BLOOD LIPIDS AND PRIMARY CORONARY EVENTS. The Effect of Diet Modification. E 12271 Minnesota Medicine 52(8)0247-52, Aug Helin, P. Lorenzen, I., Garoarsch, C., 1969. and Matthiessen, M. E. ARTERIOSCLEROSIS AND HYPDXIA. Part 2. Biochemical Changes in Mucopolysaccharides

242 E 12271 (continued) E 12296 and Collagen of Rabbit Aorta Induced by Cornfield, J. and Mitchell, S. Systemic Hypoxia. Journal of SELECTED RISK FACTORS IN CORONARY Atiseroaclerosis ReseTRE-1137t295-304, DISEASE. Possible Intervention May-Jun 1969. Effects. Archives of Environmental Health 19(3)3382-94, Sep 7 E 1227E Caro, C. 0., Fitz-Gerald, J. M., and Schroter, R. C. E 12302 ARTERIAL WALL SHEAR AND DISTRIBUTION OF World Health Organization. EARLY ATHEROMA IN MAN.Nature 223 INTERNATIONAL WORK IN CARDIOVASCULAR (5211)11159-61, Sep 13, Mr" DISEASES. 1. Prevention and Control WHO Chronicle 23(8):345,67, Aug 1969.

E 12277 Blachly, P. H. E 22315 Maempel, J. V. Z. LITHIUM CONTENT OP DRINKING WATER AND THE ETIOLOGICAL ROLE OF DIABETES ISCHEMIC HEART DISEASE.New land MELLITUS IN CARDIOVASCULAR DISEASE. Journal of Medicine 281(1211-6 , ep 117-170. Israel Journal of Medical Sciences 5(4):67S-9, Ju17Ing 1969.

E 12279 Rosa, R. J. and Balloon, S. L. E 12316 EF:TCT OF RESTRICTED ENERGY AND PROTEIN Obeyeeekere, I. INTAYE ON ATHEROSCLEROSIS AND ASSOCIATED EVAL9ATION OF RISK FACTORS IN PHYSIOLOGICAL FACTORS TN COCKERELS. CORONARY HEART DISEASE IN CEYLON. Journal of Nutrition 98(3):335 -43, Jul Israel Journal of Medical Sciences IVO= 5(4):6717-7u77KUrINIF7

E 12282 E 12317 Hickey, N., Mulcahy, R., and McFarlane, R. Pick, R. and Katz, L. N. CHOLESTEROL AND CORONARY HEART DISEASE. EFFECT OF ENVIRONMENTAL CHANGES ON Journal of the Irish Medical Association THE DEVELOPMENT OF HYPERCHOLESTEROLEM/A b2t380:270'43,-ATITI907--- AND ATHEROSCLEROSIS IN CHOLESTEROL OIL FED COCKERELS. Israel Journal of Medical Sciences 5(4):635-8, furAug E 12283 1969. Miller, F. and Kuschner, M. ALPHA-1-ANTITRYPSIN DEFICIENCY, EMPHYSEMA, NECROT/ZINO ANOIITIS AND E 12318 014MERULCNEPERITIS.American Journal of American Journal of Public Health and Medicine 46(4):615-237W117677--- the Nation's Health. Lin STYLES IN THE PREVENTION OF CORONARY HEART DISEASE.American E 12289 Journal of Public Health Hyams, L. and Loop, A. RrtOirsffealth S9[ 1713.617C THE EPIDEMIOLOGY OF MYOCARDIAL INFARCTION gep1969 . AT TWO AGE LEVELS. American Journal of Epidemiology 90(2):937OrTrur11177 E 12332 Garbarsch, C. matthiessen, M. BO, Helin, P., and Lorenzen, I. E 22290 Part Doyle, J. T. ARTERIOSCLEROSIS AND HYPDXIA. CAN CORONARY HEART DISEASE BE PREVENTED, 1. Gross and Microscopic Changes in American Journal of Medical Sciences Rabbit Aorta Induced by Systemic Klvoxia. Histochemical Studies. 2111(7)7F17977irg1T69. Journal of Atherosclerosis Research 9(3):28$:174, May-Jun 1969. E 12294 Thomasson, H. J. PROSTAGLANDINS AND CARDIOVASCULAR E 12343 DISEASES. Nutritio et Dieta 11(3)3 Higgine, I. T. T., Higgins, M. W., 228-40, 196v. Lockehin, M. D., and Canal., N. CORONARY DISEASE IN MINING COMMUNITIES

243 44'7 E 12343 (continued) E 12362 (continued) IN MARION COUNTY, WEST VIRGINIA. a multifactorial genesis. There is an Journal of Chronic Dimness 22(3): age factor, a metabolic factor, an 113---Tr.f7 riiertYarr unspecific mesenchymatie reaction and other parameters, all of Which interact in a complex manner. There are no E 12344 conclusive statemente on the harm of Murnaghan, D. J., Ryan, M. P., Hickey, cigarette smoking. N. J., Maurer, B. J., Hingeroy, D. J., and Mulcahy, R. MAGNESIUM LEVELS IN PATIENTS WITH E 12365 CORONARY HEART DISEASE. Journal Reid, D. D. of Atherosclrosis Researarra(r): LE TABAC ET LE COEUR. (TOBACCO V5-7, JUl-Aug AND THE HEART.) Journal de Medecine de Lyon (1166)197a, 993- r',-77-521 ,T9MFrench (Abs.) E 12345 Enticknap, J. B., Gooding, P. G., This is the second article in the Lansley, T. S., and Avis, P.R.D. series especially written for the PLATELET SIZE AND FUNCTION IN Information Service of the WHO by ISCHAEMIC HEART DISEASE.Journal eminent specialists dealing with the of Atherosclerosis Research 10(1): added risks of death by coronary Tr-9, J\1 -Aug 1969. disease associated with tobacco usage. All the studies, epidemiological, clinical or pathological, E 12347 strongly indicate that cigarette Pal, M. P. and Nayak, K. G. smoking is one of tho factors in TREATMENT OF THROMBO-ANGIITIS the development and aggravation of OBLITERANS--A STUDY OF 74 CASES. the cardiac arteriosclerotic process. Antiseptic 66(7):495 -502, Jul 1969. The medical profession was urged to concentrate its efforts on breaking the cigarette habit. At present, E 12350 attempts to evaluate these methods Chiang, B. N., Alexander, E. R., Bruce, for the prevention of coronary R. A., Thompson, D. J., and Ting, N. diseasee are being studied. FACTORS RELATED TO ST-SEGMENT DEPRES- SION AFTER EXERCISE IN MIDDLE-AGED CHINESE MEN. Circulation 40(3): E 12383 315-25, Sep World Health Organization. INTERNATIONAL WORK IN CARDIOVASCULAR DISEASES. 2. Research. Chronicle E 12362 23(9):395-404, Sep 1969. Oberwittler, W. EPIDEMIOLOOIE DER ARTERIOSKLEROSE. (EPIDEMIOLOGY OF ARTERIOSCLEROSIS.) E 12395 Therapiewoche 19(2):50-8, Jan 8, 1969, Marshall, W. J. Jr., Stanley, E. L., German (Abs.) and Kezdi, P. CARDIOVASCULAR EFFECTS OF COLD PRESSOR Preventive aspects of arteriosclerosis liSTS, 40' HEAD-UP TILT, AND SMOKING are discussed in a literature review of ON SMOKERS AND NON-SMOKERS. Diseases 97 references, covering a 150-year of the Chest 56(4)1290-6, oct7r377-- period. Statistical evaluations found in the literature have merit only if physicians presenting them have classi- E 12397 fied and weighed their data.The con- Stout, C. cept of 'risk of incidence' appeared CORONARY THROMBOSIS WITHOUT CORONARY for the first time in 1920 in the ATHEROSCLEROSIS. Case Report. American Framingham Study. Afterwards only Journal of Cardiology 24(4):564-7707t-- connections between the cause and 1969. occurrence of arterloacleroele were presented in a more significant manner in the literature.In New York, an Anti-Coronary Club has been in existence for about 10 years, Members maintain themselves on a 'prudent' diet, but data obtained up to now suggest that the diet as such le vorthless. Presumably, it is correct to say that arteriosclerosis has

244 a48 E 12403 E 12455 Kloeze, J., Houtsmuller, U. M. T., and Fiegel, G. Vies, R. O. RISIKOFAKTOREN BEI "JUVENILEN" HERZIN- INFLUENCE OF DIETARY FAT MIXTURES ON FARKTEN. Untersuchung Bel 136 Patlenten. PLATELET ADHESIVENESS, ATHEROSCLERO- (RISK FACTORS IN "JUVENILE" MYOCARDIAL SIS AND PLASMA CHOLESTEROL CONTENT IN INFARCT. Studies on 136 patients.) Munchener Medizinisehe Wochenschrlft RABBITS. Journal of Atherosclerosis Research 9(3):31g-3r, May-Jun 1969. 111(40):2020-2, Oct 3, 1969, German (Abs.) One hundred and thirty-six patients, E 12408 ranging in age from 23 to 39 years (mean Stamler, J. REDUCING CARDIOVASCULAR RISK. age 35.8 years) who had survived a myocardial infarction were subjected to The Basis and Feasibility. "risk Minnesota Medicine 52(8):1342-5, an examination for the presence of factors" during the stage of follow-up Aug 1269. treatment.The examinations concentrated on the 4 factors: diabetic metabolic situation, cholesterol level, weight E 12445 relationship and hidden focal lesions. Harkavy, J. CARDIOVASCULAR MANIFESTATIONS DUE TO No risk factor could be demonstrated in New York State only 3 patients. In 35 patients one risk HYPERSENSITIVITY. factor could be found, in 43 patients 2, Jburn 1 of Mediciner1=70g77g5, in 44, 3 and finally in 11 patients with Nov , 1 179. infarctions all 4 factors were found simultaneously.Six heavy smokers were included in the one-risk-factor statis- E 12447 Robin, E. and Bing, R.-J. tics. ACTION DE L'ALCOOL, DE LA NICOTINE ET DE LA FUMEE DE CIGARETTES SUR LE COEUR. (THE ACTION OF ALCOHOL, NICOTINE AND E 12462 CIGARETTE SMOKE ON THE HEART.)Medecine Magyar, E. et Hygiene 26(834)8857-65, Aug 15, 1968; INCIDENCE OF CORONARY SCLEROSIS AND MYOCARDIAL INFARCTION IN HUNGARY IN THE nench (Abs.) LIGHT OF STATISTICAL DATA DERIVED FROM Acta Medics, Academiae Alcohol was discussed under the fol- AUTOPSY MATERIAL. lowing headings: Historical consider- Scientiarum Hungaricee 26(3):26377-00. ations; metabolism of alcohol, effect of alcohol on myocardial metabolism; electrocardiographic modifications in E 124 75 alcoholic cardiopathy; effect of alcohol Haines, C. O. on coronary circulation and hemodynamics; CORONARY HEART DISEASE AND SMOKING. Journal and consumption of beer and cerdio- A Reducible Risk Factor. of the Medical Association77073rgia myopathies.The action of nicotine and cigarettes is dealt with under these rE(TasTi67-ba 969. headings: Historical considerations; Pharmacology of nicotine; effects of nicotine on the coronary circulation; E 12480 effects of nicotine on the cardiac Malmros, H. DIETARY PREVENTION OF ATHEROSCLEROSIS. contractility and hemodynamics, effects Lancet 2(7618)8479-84, Aug 30, 1969. of cigarettes and nicotine on thrombus formation; and physiological effects of carbon monoxide produced by the combus- E 12485 tion of tobacco. Glassford, R. G. and Howell, M. L. SMOKING AND PHYSICAL FITNESS: A PRELIMINARY REPORT. canallan Family E 12451 Murphree, H. B. and Schultz, R. E. Physician 15(10):60-2, Oct 1969. ABSTINENCE EFFECTS IN SMOKERS.Supported by a grant from the American Medical AsSociation Education and Research E 12491 Linhart, J., Prerovsky, I., Dejdar, R., and Foundation. Abstracts Federation Proceedings 27(2)8220, 1968. Hlavova, A. GANGRENE IN ISCHEMIC DISEASE OF THE LOWER EXTREMITIES. Angiology 20(9)8526-8, Oct 1969.

245 a49 E 12496 E 12507 (continued) Reader, R. THE EPIDEMIOLOGY OF CORONARY HEART Twenty-eight patients, including 1 DISEASE IN AUSTRALIA.Australasian diabetic, were studied.Nineteen of Radiology 13(3):258-61, Aug 1969. the thromboangiitis patients still survive and 8 had died after duration of the disease of 11-38 and 1-16 years, E 12497 respectively. A series of conservative Alexander, J. K. treatments were, by and large, without EXERCISE AND CORONARY HEART DISEASE. effect.This held true also for therapy Cardiovascular Research Center Bulletin with sex-hormones and vasodilating prep- 8(1)12-7-, Jul-Si:TT= arations. None of the patients stopped smoking permanently. In a number of cases, lumbar sympathectomy had produced E 12499 favorable effect despite continuance of Journal of the American Geriatrics smoking. In 38 lower limbs in 24 Society. patients, infections, ulcerations and CHANGES IN DIET TO LCWER RISK OF HEART gangrene developed.In 14 lower limbs ATTACK. Journal of the American in nine patients, leg or thigh GerlatricinEgity 17(I0)11012-4, emputattme were undertaken. In a Oct 1969. number of patients, signs of complicating arteriosclerosis occurred, In seven cases, cardiac diaesse, possibly arterio- E 12501 sclerotic, was the direct or indirect Kaetl, O. cause of death. BERUFLICHE UND UMWELTANALYSE INFARKTKRAN- KER EISENBAHNBEDIENSTETER. (OCCUPATION- AL AND ENVIRONMENTAL ANALYSIS OF INFARCT E 12510 PATIENTS IN RAILWAY SERVICE.) Bernameler, A. and Held, K. Medizinieche Klinik 64(42)11911-7, THROMBANGITIS OBLITERANS CEREBRI. Oct 17, 1969,757all (Abs.) (THROMBOANGIITIS OBLITERANS CEREBRI.) Zeitschrift fur Kreislaufforschung Two hundred and seventy-five male t8(9):1002-117 Sep 1969, German (Abs.) railway employees of a rehabilitation hospital, up to 65 years, who had There is still no agreement whether survived myocardial infarct were thromboangiitis obliterans cerebri le a investigated regarding risk factors of distinct nosological entity or rather a infarct. Only 3.26 percent represented special form of cerebral arteriosclerosis. workers below the age of 40 years. This review deals with the present con- Diabetes was manifest in 8 percent of the cepts and arguments of the pathology, the cases. The incidence of infarct in clinical appearance, the etiology and occupationally nonphysical activity was pathogenesis, the prognosis and therapy of 2.2 times as great as in physically- this disease. The diagnostic validity of active employees. The majority of the pathological findings well known from infarct patients lived in large cities many observations is still controversial. and geographically in the north and the The clinical diagnosis presents even more more industrialized areas of Germany. difficulties because definite reactions to The unfavorable influence of nicotine establish the diagnosis are still lacking. was confirmed; a control group of non- Clinical findings are either focal or infarct subjects smoked significantly neurological deficiencies progressing leas than the infarct patients. The from symptoms of intermittent cerebral influence of the psychodynamics of the ischemia to the signs of complete cerebral Personality on myocardial risk was infarction. Other cases present manifes- significantly evident. tations of psychiatric disorders. Special diagnostic procedures (cerebral angiography, pneumoencephalography. EEG) I& 12507 may support the clinical diagnosis in Nielsen, J. some cases. Often it may prove difficult THRCMBANGIITIS OBLITERANS BUERGER. to distinguish this disease from arterio- En Prognoseatudie. (THROMBOANGITTIS sclerosis of the cerebral vessels, since OBLITERANS (BUERGER'S DISEASE). manifestations of thromboangiitis A Study of the Prognosis.) Ugaakrift obliterans cerebri usually occur also in for Eger 131(41):1740 -51, Oct 9, the middle or older age group and are not 1r69, Danish (Abs.) confined to males only. An established

246 250 E 12510 (continued) E 12550 causal therapy of this rare disease is Finn, F., Hickey, N., O'Doherty, E. F., not known. Surgical correction of and Mulcahy, R. vascular stenoses and an anticoagulant- THE PSYCHOLOGICAL PROFILES OF MALE AND therapy to prevent further thromb- FEMALE PATIENTS WITH CORONARY HEART embolic complications are recommended. DISEASE. Irish Journal of Medical A consequent treatment of cardiac and Science 2(77319-4 , circulatory disorders is directed against additional hemodynamic dieturbances. (Author Abstract) E 12552 Doyle, J. T. SMOKINO AND MYOCARDIAL INFARCTION. E 12515 Circulation 39-40 (5, Suppl. 4: Bozyk, Z. 13 6707R37 1969. CHOROBA WIENCOWA WSROD MIES2KANCOW DZIELNICY MOKOTOW M.ST. WARSZAWY URODZONYCH W LATACH 1927, 1912 I 1897. E 12553 (CORONARY DISEASE IN THE POPULATION OF Bassett, D. R., Abel, M., Moellering, THE MOKOTOW QUARTER OF WARSAW BORN IN R. C., Jr., Rosenblatt, 0., and Stokes, THE YEARS 1927, 1912 AND 1897.) Polski J. odnik Lekareki 24(41)11573-4, MT-1.3, CORONARY HEART DISEASE IN HAWAII: olish (Abs.) DIETARY INTAKE, DEPOT FAT, "STRESS," SMOKING, AND ENEMY BALANCE IN In a representative sample of 588 HAWAIIAN AND JAPANESE MEN.American inhabitants of the Mokotow quarter of Journal of Clinical Nutrition 22(11): Warsaw born in 1927, 1912 and 1897 who 1483-1503; Nov 196%. were subjected to an inquiry investigation the author selected 155 subjects with suspected coronary disease. These E 12554 subjects were submitted to cardiologic Bassett, D. R., Abel, M., Moellering, examinations to study the effects of R. C., Jr., Rosenblatt, 0., and various factors which could have an in- Stokes, J. fluence on the development of this DIETARY INTAKE, SMOKING HISTORY, ENERGY disease. (Author Abstract) BALANCE, AND "STRESS" IN RELATION TO AGE, AND TO CORONARY HEART DISEASE RISK IN HAWAIIAN AND JAPANESE MEN IN E 12523 HAWAII. American Journal of Clincial Naeye, R. L. Nutrition 22(11):15 a:M7 Ray 1969. PATHOLOGY OF THE .7121ONARY CIRCULATION. In: Liebow, A. A. and Smith, D. E. (Editors). The Lung. International E 12556 Academy of Pathology Monograph. Rimington, J. Baltimore, Md., The Williams and CHRONIC BRONCHITIS, SMOKING AND SOCIAL Wilkins Co., 1968, pp. 164-86. CLASS. A Study Among Working People in the Towns of Mid and Eaat Cheshire. British Journal of Diseasea of the E 12526 Chest b3(4)0.93465, Oct 19617 Oerami, S., Payan, H. M., and Wojnar, V. S. ROLE OF ESTROGEN IN ARTERIOSCLEROSIS AND CARDIOVASCULAR COMPLICATIONS. SUngical E 12559 For 20197-8, 1969. Reid, D. D. THE DESIGN AND CONDUCT OF CLINICAL TRIALS IN MYOCARDIAL INFARCTION. E 12531 Circulation 39-40 (5, Suppl. 4): Morooks, T. a..v. Kuwae, T. p1-8, Nov 1969. CARDIOVASCULAR MORTALITY IN JAPAN AND IN THE UNITED STATES.Bullatin of the Heart Institute, Japam 121 91-116, 1V617 E 12608 °sell, O. RAUCHEN UND HERZERKRANKUNOEN. (SMOKING E 12544 AND HEART DISEASES.) Suchtgefahren Havlik, R. J., Feinleib, M., Garrison, 15(2):1 -11, Apr 1969, German (Abs.) R. J., and Kannel, W. B. BLOOD-OROUPS AND CORONARY HEART- Several studies on the causal DISEASE. Lancet 2(7614)1269-70, connection between cigarette smoking and Aug 2, 19637- cardiovascular diseases were reviewed. The studies included the 1964 Terry Report

267 as! E 12608 (continued) E 12650 and its 1967 supplement "The Health Vessey, M. P. and Doll, R. Consequences of Smoking".Both the acute INVESTIGATION OF RELATION BETWEEN USE forms of heart disease (tobacco heart, OF ORAL CONTRACEPTIVES AND THRCEBO- tobacco angina or nicotine angina pectoris) EMBOLIC DISEASE.British Medical and the chronic forms (coronary sclerosis Journal 2:199-205, Apr 27, 19n. and its consequences, myocardial infarct, and heart attack) were discusLed. The report featured the following tables E 12710 which were entitled: Risk factors of Valgma, K. A. myocardial infarct of 75 men up to 70 AKTOPU, CnOCOECTX0'6lYCXAXV6E PA3)1(14TIVY years of age (Osell 1966); mortality rates ncxEnomaciu EC1E3F41 CEPATCA. in coronary heart disease in relation to the intensity of cigarette smoking (Hammond and Horn); Age-specific mortality FAKTCEY, SPOSOBSTVUYUSHCHIYE RAZVITIYU rates in coronary heart disease based on ISHEMICHESKOY BOLEZNI SERDTSA. (FACTORS 100,000 individuals according to age, sex CONTRIBUTING TO THE DEVELOPMENT OF and smoking habits (Hammond 1966); ISCHEMIC HEART DISEASE.)Vrachebnoe coronary diseases and tobacco smoking; Delo (4):145-6, Apr 1969, Russian (Abs.) and risk factors for the development of coronary disease (coronary sclerosis, Risk factors for ischemic heart myocardial infarct, heart attacks). disease were investigated in 176 (120 male, 56 female) stenocardia patients; the control group having the E 12617 [same male-female ratio, consisted of 102 Reid, D. D. healthy subjects or patients hospitalized LE TABAC ET LE COEUR. (TOBACCO AND THE for nonatherosclerotic causes.Ages HEART.) Revue d'Hygiene et de Medecine ranged from 32 to 68 for stenocardia pa- Sociale 16(8):791-4. Decrgar. tients and 30 to 65 for controls; 52.4 WeITEr(Abs.) percent of stenocardia patients and 43.2 Percent of controls were smokers. A Results of recent epidemiological study of both groups indicated that the studies on the effects of tobacco on moat frequent risk factors for iechemic the heart have been reviewed. The heart disease were hypertension, differ- studies demonstrate that smoking, ences in inherited predisposition, other especially heavy cigarette smoking, concurrent illnesses, emotional stress, increases the risk of coronary disease. sustained occupational mental stress and In all of the studies, the apparent physical inactivity. effect of cigarette smoking was moat clearly evident in men below 50 years of age. In general the effect in women E 12717 was less clear. A lower incidence of Walker, A. R. P. coronary disease was observed in those CORONARY HEART DISEASE--ARE THERE who habitually smoked a pipe or cigars. DIFFERENCES IN RACIAL SUSCEPTIBILITY? Other clinical [studies have shown that American Journal of Epidemiology 90(5): cigarette smoking induced blood changes 359-64, Nov 1969. which increase the risk of thrombotic Processes in arteries supplying the heart. Nicotine which increases the pumping E 12721 action of the heart, when linked with Abou-Daoud, K. T. an already-reduced oxygen supply to CORONARY HEART DISEASE ASSOCIATIONS the heart caused by carbon monoxide of OBSERVED IN HOSPITALIZED PATIENTS. the smoke reacting with hemoglobin in Journal Medical idbanais 21(2):49- the blood, places a heavy burden on an 3771lar-A-137r08. already deficient heart. Physicians were urged to induce their patients, especially those in middle age with E 12726 clinical signs of coronary disease to Kidner, P. stop smoking altogether.Those in- RECOVERING FROM A HEART ATTACK. Regular capable of doing ao, should be Exercise and a Sensible Diet Can Help encouraged to substitute a pipe or Sufferer6 from Heart Attack Back to a cigars. Normal Life.Health 6(5)[24-8, Oct 1969. E 12728 E 12799 World Health Organization. Rime, B., Segera, M. J., and Mertens, C. SOCIAL CLASS AND ARTERIOSCLEROTIC HEART L'EPIDEMIOLOGIE DE L'ATHEROSCLEROSE DES DISEASE.WHO Chronicle 23(11)1532-4, CORONAIRES EN BEIOIWE. (EPIDEMIOLOGY Nov 1969. OF ATHEROSCLEROSIS OF THE CORONARIES IN BELGIUM.) Acta Cardlologlca 24(5)1 482-95, 1969, itlizch (Abs.) E 12732 Paaby, H. and Stadil, F. From 1955 to 1965, an obvious THROMBOSIS OF THE ULNAR ARTERY. Acta annual progression of the coronary Orthopaedics Scandinavica 39(3):331.45, heart mortality is observed in Belgium. 1968. This Progression occurs parallel in male and female, but is of lower intensity for the latter. Yet the female coronary E 12735 heart mortality tends, from year to Sibley, J. C. year, to approach the male mortality. MEDICAL MANAGEMENT OF THE HEART VICTIM. As concerns the female subjects, the Canadian Family, Physician 15(11):60-3, atherosclerotic heart mortality is of RUV1V66. lesser Importance before the age of forty.After this age, the levels begin to rise with age, while the maximal E 12742 mortality is observed much later in life Ohaffar, M. A. than for men.The role of moclo-cultural IS THE ROLE OF HYPERCHOLESTEROLAEMIAE IN factors in this evolution of atheroscle- THE ETIOLOGY OF CORONARY DISEASE rotic heart disease is discussed. UNASSAILABLE? Pakistan Journal of (Author Abstract) Geriatrics 7(2)762-67Cr 1969.

E 12743 Abdul Wahed, A. K. M. See alsoB 10249, B 10546, B 10601, ROLE OF FATS IN CORONARY DISEASES E711434, B 11988, B 12140, D 10801, (HYPERLIPAEMIA). Pakistan Journal D 12054, D 12063, D 12064, D 12503, of Geriatrics 7(2)19 -10, Apr 1961. J 12215

E 12746 Stead, E. A., Jr. WHAT WE HAVE LEARNED ABOUT MYOCARDIAL INFARCTION FROM EPIDEMIOLOGIC AND DIETARY STUDIES. Circulation 40(5, Suppl. 4):IV-85-IV-90, Nov 1969.

E 12748 Stamler, J., Schoenberger, J. A., Lindberg, H. A., Shekelle, R., Stoker, J. M., Epstein, M. B., deBoer, L., Stamler, R., Reetivo, R., Gray, D., and Cain, W. DETECTION OF SUSCEPTIBILITY TO CORONARY DISEASE.Bulletin of the New York Academy of Medicine-15=71306-25, Dec 1969.

E 12796 Puri, P. S. and Bing, R. J. INFLUENCE OF CARDIOVASCULAR DRUGS ON THE FORCE-VELOCITY RELATION OF THE INTACT HEART. Abstract of paper Presented at the American Physiology Society, Washington, D. C., Howard University College of Medicine, Aug 21-25, 1967. phylioloAist 10(3)1285, Aug 1967.

249 253 SECTION F. OTHER DISEASES AND CONDITIONS

F 10e68 F 10318(continued) Noojin, R. O. TREAT LEUKOPLAKIA EARLY AND DETER CANCER. Among 5 patients with tobacco Consultant 8(2):18-20, Feb 1968. amblyopia, a severe disturbance in vitamin -B12- absorption was found by means of the Schilling test in 2 cases. In all F 1°275 5 cases, the disturbance of vision Joreinn, P. H., Jr. improved after treatment with vitamin B12 CLINICAL ASPECTS OF GASTRIC SECRETION (Aquocobalamine acetate); in 4 of them In AND GASTRIC ANALYSIS.Medical Clinics spite of the continued abuse of tobacco. of NoMrth America 52(6):1305-15,7R67--- According to these results it seems like- PA ly that a deficiency in vitamin B12 assumes a decisive role in the development of tobacco amblyopia. Pathogenesis and F 10288 therapy of the clinical picture are die- Bowles, W. T. cussed in detail. HEMATURIA: WHEN DOES IT PROBABLY MEAN CANCER? Consultant 8(1):20-3, Jan 1968. F 10357 Shuler, R. L. F 10297 EFFECT OF CIGARETTE SMOKING ON THE Current Medicine for Attorneys. CIRCULATION OF THE ORAL MUCOSA. Journal DRIVERS' NEGLIGENCE DUE TO THEIR IMPAIRED of Derntal Research 47(6):910-5, Nui=n-F- PHYSICAL CONDITION. Current Medicine for Attorneys 15(62):36717.707 1968.

F 10361 F 10317 Terris, M. and Gold, E. M. Grassi, V., Fornari, G., Marcheai, N., and AN EPIDEMIOLOGIC STUDY OF PREMATURITY. Duranti, G. 1. Relation to Smoking, Heart Volume, PNEUMOPATIE CRONICHE ED ULCERA PEPTICA: Employment, and Physique.American ANALISI DEI FATTORI INFLUENZANTI Journal of Obstetrics and dgraTeTERY L'ASSOCIAZIONE. (A STATISTICAL STUDY OF 103(3):356 -70, Feb 1, rm. THE FACTORS INFLUENCING THE ASSOCIATION OF CHRONIC LUNG DISEASE AND PEPTIC ULCER). Rassegna di Fisiopatologia Clinica e F 10370 TerapeutiEE 4012J:160-7i, AfFITIM, Russell, C. S. Iltalian Abs.) ANOTHER HAZARD OF SMOKING. New Scientist 41(631):64-5, Jan 771969. The rate of incidence of peptic ulcer was statistically evaluated in 309 patients with partial chronic repiratory F 10403 failure (hypoxia and hypercarbia). A Tuchmann-Duplessis, H. significant difference of incidence of INFLUENCE OF ENVIRONMENTAL AGENTS ON peptic ulcer in these groups of patients MAMMALIAN FOETAL DEVELOPMENT. with chronic lung disease was not found. Proceedings of the FloAl Society of Peptic ulcer was found to be significantly kedicine 61(r7)TINT=TU; Dec 1968. correlated to the presence of polycythemia and to the duration of the disease. While smoking was considered one of the factors F 10433 responsible for chronic inflammation of Legrand, J. the respiratory apparatus it wee not seen LA FONCTION VISUELLE ET AL CONDUITE as a decisive factor in the development of AUTOMOBILE. (THE VISUAL FUNCTION OF ulcers in pneumopathic patients. THE AUTOMOBILE CONDUIT.)Annales d'Oculietique 20911):1081=T67--- Nov 1968, French Abs.) F 10318 Kommerell, G. and Castrillon-Oberndorfer, The alarming increase in road W. L. accidents is due to numerous causes TABAK-AMBLYOPIE. BEITRAG ZUR PATHOGENESE among which all that can alter the UND THERAPIE. (TOBACCO AMBLYOPIA. A driver's vision plays an important CONTRIBUTION TO PATHOGENESIS AND THERAPY.) role. The visual function is involved Klinische Monatablatter fur Augenheilkunde in making bad conditions for visibility 153(4)1551-62-, Nov 196g, Merman Ace.) (driving at night or at cilsk, dazzling by badly placed headlights and sidelights, badly marked or badly lit

250 zt F 10433 (continued) F 10493 roads) and in impairing the driver's Hoon, J. R. vision (bad central acoaty, alterations INTRAGASTRIC PHOTOGRAPHIC OBSERVATION in the visual field, :engthening of the OF THE EFFECTS OF SMOKING ON GASTRIC time of sensory motor action under the MUCOSA. Gastrointestinal EndoscoPY influence of fatigue, alcohol, etc.., 15(3):172-4, Feb 19E-9. ocular afflictions, troubles of the chromatic sense, monophthalmy). Tobacco likewise influences vision F 10498 by increasing the carbon monoxide Garrett, J. M., DuBose, T. D., Jr., content in the blood.Perdriel and Jackson, J. E., and Norman, J. R. Desbordes have noted that four ESOPHAGEAL AND PULMONARY DISTURBANCES cigarettes smoked consecutively in IN MYOTONIA DYSTROPHICA. Archives a non-ventilated vehicle can lower of Internal Medicine 123(1):26-32, the noctural visual capacity by 20 Jan 1969. percent. It would be desirable, to limit these deficiencies and the dangers they entail, if the road were F 10511 lit, the vehicles were often checked Fine, B. J. and if the driver had an ophthalmic PERSONALITY TRAITS AS RELATED TO examination to verify the soundness of SYMETOMATOLOGY AND RUNNING PERFORMANCE his vision. AT ALTITUDE UNDEa NORMAL AND DRUG (ACETAZOLEAMIDE) CONDITIONS. Perceptual and Motor Sills 27:975-90, F 10458 1968. Ambanelli, U. CONSIDERAZIONI SULLA ASSOCIAZIONE SILICOSI-SCLERODERMIA. (OBSERVA- F 10517 TIONS ON THE SILICOSIS-SCLERODERMA Goldsmith, J. R. and Lan01,14, S. A. ASSOCIATION.) Medlcina Clinica e CARBON MONOXIDE AND HEALTH. Sperimentale 16(.077:Tg, 2968, Science 162(3860):1352-9, Dec 20, 1968. Italian (Abz.)

A case of generalized sclero- F 10540 dermia in a patient with pulmonary National Center for Health Statistics. silicosis is described. In this INFANT AND PERINATAL MORTALITY IN case the urinary excretion of the ENGLAND AND WALES. Pregnancy intermediate metabolites of the Complications and Disorders of tryptophane-nicotinic acid pathway Maturation. U. S. Department of was determined.The following Health, Education, and Welfare, discussion is based on the data of Public Health Service, Washington, the literature and on the suggested D. C., Monthly Vital Statistics immunologic pathogenesis of the Report, Provisional Statistics silicosis. The alterations of Report, National Center for Health tryptophane metabolism detected in Statistics, Series 3(12):34-40, Nov the present case were not dissimilar 1968. to those observed in other patients with generalized sclerodermia. (Author Abstract) F 10548 Bronshteyn, Ye. I. BonPOCY 06 ANEPFINECKM ItnAWAX. F 10461 U. S. Medicine. K VOPROSU OB ALLEROICHESKIKH PREGNANT WOMEN TOLD TO BREAK SMOKING OEPATITAKH. (ON ALLERGIC HEPATITIS). HABIT. U. S. Medicine 4(22)116, Nov Terapevticheskil Arkhiv 40(12)352-7, 15, 1968. 1968, Russian (Abi7)--- The author describes a group of F 10462 225 patients with allergic diseases Seylaz, J. and Molnar, L. who in their clinical picture had A STUDY OF THE CONTROL OP CEREBRAL signs of hepatic lesions. Out of the BLOOD FLOW IN THE FREELY MOVING above number the author describes a aABBIT. Archives Italiennes de group of furriers 126 strong who had Biologie 106(2):157-64, May 13'68. ursol allergy and the liver was

251 4255 F 10548 (continued) F 10679 involved in 92.8 percent of the cases. Drutz, H. P. They also had other allergic manifesta- PERINATAL DEATH AND PREMATURE LABOUR. tions. Out of 39 workers with allergy University of Toronto Medical Journal to tobacco on tobacco plantations 46(3):88-91, JTE-rggg. liver lesions were present in 94.8 percent. Out of 60 patients with nonprofessional allergic manifestations F 10682 liver lesions were present in 68.3 Bockel, R. percent of the cases.They complained TRAITEMENT MEDICAL DE L'ULCERE of pains and dyspepsia. The liver was GASTRO-DUODENAL NON COMPLIQUE. enlarged mostly at the expense of the (MEDICAL TREATMENT OF UNCOMPLICATED left lobe. It was somewhat hard. GASTRODUODENAL ULCER.) StrasbourK Allergic nature was confirmed by Medical 19(6):592-602, Jul-Sep allergic tests and histological data. 1968, French (Abs.) (Author Abstract) To measures such as rest, diet and suppression of tobacco, one may F 10573 utilize medications for the purpose Jackson, J. A. of checking secretory activity and HEAVY SMOKING--A FACTOR IN DELAYED stomach motility, neutralizing SOCKET HEALING. National Dental gastric content and protecting the Association QuaraFTITTIg-17-53E gastroduodenal mucosa. Tobacco must 1950. be forbidden since it is known to stimulate gastric secretion. If complete suppression in very heavy F 10574 smokers is not possible, it may be Jackson, J. A. authorized only in the postprandial ORAL PATHOS:S AND HEAVY SMOKING. period. Journal of tile Philippine Dental Association- 7(4):13 -8, Dec 196g. F 10747 Kika, K. F 10582 NINSHIN NO KITSUEN. (SMOKING IN Roberts, D. M. PREGNANCY.) Sanfujirika no Jissai THE MEDICAL TREATMENT OF PEPTIC 15(7):611-4, Jul 19C6, aliariirrtAbs.) ULCERATION WITH SPECIAL REFERENCE TO ANTICHOLINERGIC DRUGS. Clinical Studies on the relation between Medicine 76(2):24-7, Feb7307-- smoking in pregnancy and the incidence of prematurity and other obstetric complications are reviewed. These F 10621 studies were mainly published in the Stucki, D. and Montesinos, F. American literature between 1957 and LE CERCLAGE DV COL UTERIN ET SES 1965. INDICATIONS. (CERCLAGE OF THE CERVIX AND ITS INDICATIONS.) Praxis 57(52): 1829-34, Dec 1968, French (Abs.) F 10768 Sharp, D. V. Cerclage of the cervix by MscDonald's TOBACCO AMBLYOPIA.ANOTHER CASE method has been extended to other con- AGAINST SMOKING. Ea Physician ditions such as habitual or possible 2(3):12-4, Mar 1969. spontaneous abortion. Results of terclage in 55 cases during 1966 and 1967 wv'e reported. Maternal smoking and cons'Amp- F 10800 tion of alcohol were l4sted among other Vrcelj, S., Rodic, S., and Tesanovic, causes of spontaneous abortion. One M. dozen select cases were presented. nEraktini YAM Y 60IEDWA CA XPO-41wit1 nY1140:0A144CPuDi. PEPTICKI ULKUS U BOLESNIKA SA F 10654 HRONICNIM PULMONALNIM SRCEM. Oillies, M. and Skyring, A. (PEPTIC ULCER IN PATIENTS WITH GASTRIC ULCER, DUODENAL ULCER AND PULMONARY HEART DISEASE.) SrPski, GASTRIC CARCINOMA: A CASE-CONTROL STUDY Arhiv za Celokupno Lekarstvo OF CERTAIN SOCIAL AND ENVIRONMENTAL 3g177:377-81, Apr 13W-U0go- FACTORS. Medical Journal of Australia Croation (Ab..) 2(25):1132=67-EiF 21, 1968.

252 F 10800 (continued) F 10853 (continued) and fertility in males and females were Peptio ulcers were found on obduction reviewed. One study showed a higher of 47 deceased patients with chronic, thiocyenate content in the cervical decompensated, pulmonary heart disease. mucus of female heavy smokers (5 mg: In 21.3 percent of the cases, they were 0.2-1.0 percent); 1 percent can located in the stomach and duodenum. A inhibit sperm motility.Certain comparision of these findings and ulcer investigations in men have shown a localization in patients with chronic higher rate of oligospermia and pulmonary heart disease and patients with hypospermia in heavy_smokera than in cardiac insufficiency of other etiologies nonsmokers, but no valid conclusions showed that ulcers were more frequent in could be drawn from such differences. newly admitted patients and more frequent Tests in male heavy smokers have shown in the stomach. decreased sperm motility.

F 10818 F 10854 Cozzolino, G., Scianaro, L., Rottini, E., Hickl, E.-:. and Bisaanti, A. SCHWANGERSCHAFT. (PREGNANCY). In: REPERTI BIOCHIMICI SUL METABOLISMO Schievelbein, H. (Editor). Nikotin: TRIPTOFANO--ACIDO NICOTINIC° IN CORSO Pharmakologie und Toxikologie des DI EPATOPATIE ACUTE E CRONICHE. Tabakrauches. Stuttgart (West Germany), (BIOCHEMICAL FINDINGS ON TRYPTOPHAN- Georg Thieme Verlag, 1968, pp. 255-60., NICOTINIC ACID METABOLISM DURING THE German (Abs.) COURSE or ACUTE AND CHRONIC LIVER DISEASES.) Acta Vitaminologica et Clinical investigations have shown Enz olo ica=r5):145-55, 1965,-- that smoking inures both mother and a an n s.1 child. While cigarette smoking does not appear essentially to influence gestosis An altered tryptophan metabolism, in mothers, the greater incidence of with increased urinary excretion of abortions and lighter weight of the neo- kynurenine and acetyl-kynurenine, and nates in smoking mothers have been con- decreased 3-0H-anthranilic acid firmed. The significance of maternal excretion, was noted in 14 subjects smoking in perinatal infant mortality has suffering from acute liver disease. been disputed and there appears to be no Simultaneous study of these metabolites relationship between maternal smoking and together with the bilirubin serum levels malformations and the sex of the off- and transandnases revealed a parallel spring. Apart from other considerations, trend in the relevant curves, indicating at least mothers with pregnancy risks for overall improvement of the hepatic cell children should be cautioned against function: in particular, it was noted smoking. Smoking of the father appears that the changes for bilirubin serum to have no influence upon the offspring. levels and 3-0H -anthranilic acid were no longer evident after the 21st day of observation, whereas the others F 10856 persisted until the 28th day. In 10 Hollwich, F., Zunemann, 0., and Damaske, E. chronic liver disease sufferers, the AUGE. iEYES.) In: Schievelbein, H.

only change encountered wall that urinary (Editor . Nikotins Pharmakologie und elimination of 3-0H-anthranilic acid was Toxikologie des Tabakrauches. Stuttgart much decreased. In all 24 subjects a dose (West Germany), Georg Thieme Verlag, of tryptophan accentuates the deviation 1968, pp. 267-77., German (Abs.) already present. The influence of smoking on the eyes and vision and the effects of nicotine on F 10855 the retinogram and on glaucoma were re- Schirren, C. viewed. Particular attention was paid to FERTILITAT. (FERTILITY), Ins the incidence, diagnosis, and therapy of Schievelbein, H. (Editor). Nikotins tobacco-alcohol amblyopia, a disorder Pharmakologie und Toxikologie des which was attributed to smoking of tobac- Tabakrauchea. Stuttgart (West Germany), co with a high nicotine content or smok- Georg Thieme Verlag, 1968, pp. ing cigar-and cigarette butts, consump- 250-4.,German (Abs.) tion of strong, relatively low-grade alcoholic beverages, and a disposition to Experimental and clinical data a generally weakened condition. Auditory concerning the relationship of smoking problems associated with tobacco alcohol amblyopia were also considered.

233 X s? F 10'7,A otahlhofen, W. F 10916 (continued) DAS RADIOAKTIVE POLONIUM-210 IN TABAK, AND AMERICAN NEGROES AND CAUCASIANS. TABAKRAUCH UND MENSCHLICHEM GEWEBE. Neurology 19(3):205-10, Mar 1969. (RADIOACTIVE POLONIUM-210 IN TOBACCO, TOBACCO SMOKE AND HUMAN TISSUE.) In: Schievelbein, H. (Editor). Nikotin: F 10918 Phermakologie and Toxikologie des Weathers,D. R. and Halstead, C. L. Tabakrauches. Stuttgart (West Germany), HISTOLOOIC STUDY OF THE EFFECT OF Georg Thieme Verlag, 1968, pp. 285-92., 5-FLUOROURACIL ON CHEMICALLY INDUCED German (Abs.) EARLY DYSPLASIA OF THE HAMSTER CHEEK POUCH. Journal of Dental Research Several tables show (1) the polo- 48(1):157,Er-Fe6 1969. nium-210 content in cigarette tobaccos in various countries, (2) distribution of polonium-210 in main-stream and side- F 10923 stream smoke, and (3)average values World Health Organization. of polonium-210 in the bronchial tree II. SPECIAL SUBJECT.CIRRHOSIS OF THE and peripheral parenchyma, bifurcation LIVER AND ALCOHOLISM.World Health and lymph nodes of the lungs and in other Statistics Report 21(11):629-78, 1968. organs of the body.One author estimated that 41 percent of the total polonium-210 activity of a cigarette was present in F 10924 the smoke, 35 percent remained in the Weybrew, B. B. and Stark, J. E. butt and 17 percent in '.he ash. A small PSYCHOLOGICAL AND PHYSIOLOGICAL CHANGES portion of the activity remained in the ASSOCIATED WITH DEPRIVATION FROM SMOKING. filter, When present. The natural Submarine Medical Research Laboratory. radiation and the polonium-caused radia- U.S. Naval Submarine Medical Center tion ratio in the human respiratory Report No. 490, Bureau of Medicine and tract were also compared. Several Surgery, Navy Department, Submarine Base, authors have considered the percentage of Groton, Conn., Feb 23, 1967, 16pp. polonium-210 radiation insufficient to cause bronchial carcinoma, but one author has found much higher polonium-210 F 10972 activity localized in the lower bifurca- Blackburn, C.R.B., McGovern, V. J., tion of the left bronchus. Burchett, P., and Arter, W. J. LIVER DISEASE IN THE TERRITORY OF PAPUA AND NEW GUINEA. II. HISTO- F 10864 LOGICAL OBSERVATIONS ON LIVER TISSUES Perry, H. O. and Lovestedt, S. A. OF PATIENTS IN HOSPITAL. Tropical DISORDERS OF THE MOUTH (BENIGN). and Geographical Medicine 20(4): Current Therapy ;616-23, 1969. MY-16, Dec 196*.

F 10890 F 10985 Osuntokun, B. 0., Monekosso, G. L., and Morimoto, M. Wilson, J. INFLUENCE OF PANCREATIC AMYLASE ON RELATIONSHIP OF A DEGENERATIVE TROPICAL PATHOGENESIS OF EXPERIMENTAL PEPTIC NEUROPATHY TO DIET REPORT OF A FIELD ULCER. Medical Journal of Shinshu SURVEY.British Medical Journal University 13T2):75-80, it 1968. 1(5643):517-50, maTr7r9g77----

F 10995 F 10894 Zussman, B. M. Harrison, D. F. N. ALLERGIC CONSEQUENCES OF SMOKING - -A SNUFF--ITS USE AND ABUSE. In: NEW HEALTH HAZARD.Memphis and Transactions of the Pacific Coast Oto- Mid-South Medical Journal 44T3T: Ophthalmological Society, Fifty-second /6, Mar 19117---- Annual Meeting.Vancouver, British Columbia, May 12-16, 1968, pp. 47-50. F 11000 Caganova, A., Cagan, S., and Simko, V. F 10916 LIPIDY KRVNEHO SERA U NEFAJCIAROV A Williams, A. 0., Resch, J. A. and FAJCIAROV. (BLOOD SERUM LIPIDS IN Loewenson, R. B. SMOKERS AND NONSMOKERS.)Bratislayske CEREBRAL ATHEROSCLEROSIS - -A COMPARATIVE Lekarske List (5)2587-91, 1968, AUTOPSY STUDY BETWEEN NIGERIAN NEGROES Slovak (Abi-0-

254 2.51 F 11000 (continued) F 11046 (continued) well as conservative treatment of peptic, In a group of 49 young students, gastric, and other types of atonic studying at the University of Bratislava, ulcers, which would include prohibition the authors investigated blood serum of smoking. lipids and their fractions and evaluated their levels in relation to the habit of mocking cigarettes. In smokers, F 11047 statistically significantly higher Rylander, R. levels of cholesterol, iodine number, LITTFORCRENINGAR I VART SAMHALIE. beta-lipoproteins, determined by the (AIR i...:LUTION IN OUR SOCIETY.) Svenska turbidity method and by filter paper Nationalforeni en mot Njart-och electrophoresis, a higher beta: alpha- a .omar )Tgr-gi, Jul-Oct 1968, lipoprotein-index and lower values of Sw la (Abe.) alpha and 0 lipoproteins were found than in nonsmokers. The smoking of cigarettes Abstracts from this air pollution may constitute one of the adjuvant symposium are presented and indicate the factors promoting early atherosclerosis various pollutants etressed by different also by unfavorably influencing blood speakers. The effects of these pollutants serum lipids. (Author Abstract) or contaminants cannot be fully evaluated since meterological, hereditary and socioeconomic factors are involved. The coun- F 11040 try in which the pollution occurs must be Dontenwill, W., Elmenhozat, H., Reckzeh, considered also.California, for in- G., Hal!ce, H.-P. and Stadler, L. stance, is noted for excess carbon monox- EXPERIMENTELLE UNTERSUCHUNGEN UBER DIE ide in the air, and Sweden for pollution BEEINFLUSSUNG VON ABBAU UND ABTRANSPORT derived from effluents of the paper and CANCEROGENER KOMENWASSERSTOFFE IM pulp industry. Pollution in the work en- BEREICH DES RESPLIATIONSTRAKTES rCRCH vironment must be distinguished from air PASSIVE BERAUCHUNG VON GOLDRAMSTERN. pollution in the city where the work is (STUDIES ON THE REMOVAL AND CATABOLISM located.Fogs differ from locality to OF CANCEROGENIC HYDROCARBONS IN THE locality, the London fog being rich in RESPIRATORY TRACT OF GOLDEN HAMSTERS sulfur dioxide, and the Los Angeles smog EXPOSED TO SMOKE.)Zeitschrift fur high In nitrogen dioxide. It is not suf- Krebsforschung 72 1)163-4, 1969, ficient to make air analyses] the people Berman (Abs.).- affected must also be examined. Lung clearance studies, in which a patient in- It could be demonstrated that exposure hales and exhales a radioactive pollutant, of Syrian golden hamsters to cigarette are made to determine the fate of the smoke before and after intratracheal labeled compomd in the body. Genetic injection of 3.4-BP has no influence upon differences to pollution effects were catabolism or removal of BP from the studied in research on 10,000 pairs of lungs. (Author Abstract). twins who were genetically identical and exposed to similar pollutants under varying conditions.The effects of tobac- F 11046 co smoking were evaluated in a similar Hedenberg, I. manner. Central heating ie a factor in FREKVENSEN AV VENTRIKELRESEKTIONER FOR air pollution. Sweden requires more ULCUS. (THE FREQUENCY OF VENTRICLE houst, heating than the United States and RESECTIONS FCR ULCERS.) Lakartidningen even though all other factors are equal, 66(4):529-52, Jan 22, 1969, Swedish f7 a Swede during hie lifetime will be exposed to more sulfur dioxide than an A statistical evaluation is presented American.Elimination of pollution is on Surgical resections performed in two always beneficial, and elimination of Swedish military hospitals over a 10-year secondary combustion of exhaust geese from period in cases of duodenal and ventric- cars is desirable in any case. ular ulcers. These operations are especially indicated in the presence of bleeding of the ventricles or cancerous F 11057 degeneration. The operations may lead to Takaki, N, and Kono, N. complications such as stenosis and poet - I - JUNISHICHO KATY°, NAIKA NO TACHIBA cibal complaints from the patients. In KARA (DTERNALPEPTICULCERFROM THE STANDPOINT view of the obvious advantages and dis- OF T MEDICINE.) advantages, it must be concluded that 1225-33,1225 -33, Nov 1968, Japanese (Abs.) this operation does more good than harm and will in the future be used as a In the period 1962-66, 516 cases of feasible treatment. Medical opinion ie peptic ulcer were admitted to the First briefly reviewed on X-ray diagnosis, as Tokyo National Hospital. The maximum

255 a59 F 11057 (continued) F 11222 incidence of gastric and duodenal ulcers Hall, O., Sharma, O. P., Naish, P., Doe, was observed in the 50-59 and 30-39 age W., and Jame!, D. 0. groups respectively. The incidence rate THE EPIDEMIOLOGY OF SARCOIDOSIS, Post- in gastroduodenal ulcers revealed no graduate Medical Journal 45(522):2Tr:50, significant difference in the age groups Apr 1969. from 30 to 69. Comparing the incidence rates by sex, the ratio of male to female was 3:1 in gastric, 10:1 in duodenal, and F 11226 13:1 in gastroduodenal ulcer. The effect Buncher, C. R. of specific foods, stress, drugs, and CIOARETTE SMOKINO AND DURATION OF hiatus hernia on the incidence of peptic PREGNANCY.American Journal of ulcer la discussed with illustrative Obstetrics Luid-OFTFEorilfr537): examples. No mention is made of :ooking 942-6, Apr 171989. history.

F 11247 F 11089 Pylev, L. N., Roe, F. J. C., and Review of Allergy. Warwick, O. P. THE PROBLEMS OF PETS AND SMOKING. ELIMINATION OF RADIOACTIVITY AFTER Review of Allergy, 23(1)159-62, Dec 1968. INTRATRACHEAL INSTILLATION OF TRITIATED 3,4-BENZOPYRENE IN HAMSTERS. British Journal of Cancer F 11098 23(1 ):103-1977U717617 Dragstedt, L. R. PEPTIC ULCER. American Journal of Surgery 117(2):143-59,Feb 1767. F 11261 Spillane, J. D. TROPICAL NEUROLOGY. Proceedings of the F 11143 RoyalSocietyof Medicine 62(0:03-1-57 Public Health Reports. Apr 9 . PEPTIC ULCER INCREASING AMONO THOSE UNDER 16. Public Health Reports 84(3):264-5, Mar19117 F 11263 Viczian, M. DOHANYOSOKON VEGZETT ONDO-VIZSOALATOK F 11217 TAPASZTALATAI. (EXPERIENCES WITH Castro Santos, Lycurgo de, Jr. THE SPERM EXAMINATION OF SMOKERS.) CURIOSIDADES NA HISTORIA MEDICA Orvosi Hetila 109:1077-9, May 19, BRASILEIRA. (CURIOSITIES IN BRAZILIAN Mg-Hunger n (Abs.) MEDICAL HISTORY.)Annie Paulistas de Medicine e Ciru111-997)7317:n71,137/-Dec Sperm experiments performed on 120 113117FrirTuvese a. habitual male smokers have revealed cancerogenic and other deleterious Several early Brazilian notables in the effects of smoking, on spermatogenesis. field of medicine and surgery were cited Control tests were performed on abstain- and their accomplishments briefly dis- ers, and tobacco factory workers were cussed. Mention was also made of a excluded.The deleterious interference particularly barbaric therapeutic measure, in the process of mitosis is noticeable the placing in the rectum of a large among smokers of 1 to 5 years. The bolus, conflating of tobacco, salt, sperm number decrease is tapered and pimenta, copper acetate, camphor and lime stabilized beyond the 5 years smoking Juice. period. The functional activity of the mature male germ cells are also effected. Subsequent to a considerable period of F 11221 smoking the more frequent 'presence (..7 Whittingham, S., Mackay, I. R., Ungar, B., pathologic sperms is noticeable. S,.udies and Mathews, J. D. on laboratory animals have revealed that THE OENETICFACTORIN PERNICIOUS ANAEMIA. the inhalation of :smoke has impaired Laleet 1(7602):951-4, May 10, 1969. their spermatogenesis. It Is difficult to establish that sterility secan be induced by smoking.

256 F 11309 F 11427 Ondrej, M. Lucaa, G. H. W. and Imrie, R. J. ON THE REVERSIBLE CHARACTER OF DELAYED ACUTE MISCELLANEOUS POISONING.Current MUTATIONS INDUCED BY NITROSOCOMPOUNDS Therapy :881-96, 1969. IN DROSOPHILA MELANOOASTER.Folio Biologica 15(1):17-25, 1969. F 11436 Lancet. F 11311 MORE EFFECTS OF CIGARETTES. Lancet Hanaotia, P., Petera, H., Bennett, M., 1(7603):1013, May 17, 1969. and Brown, R. CHELATION THERAPY IN WEGENER'S ORANULOMATOSIS TREATMENT WITH EDTA. F 11445 Annals of Otology Rhinology & Schwarz, K. and Fredga, A. ra7rrigo'rogy 78(2):388-402, Apr 1969. BIOLOGICAL POTENCY OF ORGANIC SELENIUM COMPOUNDS. I. ALIPHATIC MONOSELENO-AND DISELENO-DICARBOXYLIC ACIDS. Journal F 11315 of Biological Chemistry 244(8):2103-10, Reuber, M. D. Ur 25, 109. INFLUENCE OF AGE AND SEX ON DIETARY- INDUCED CIRRHOSIS. Archives of Environmental Health 18(5)2797:7o May F 11451 1969. Shea, J. J., Jr. and Koniehi, S. THE MEDICAL MANAGEMENT OF FLUCTUANT HEARING LOSS. Laryngoscope 79(4):714- F 11351 26, Apr 1969. Sanchez Carvajal, M. A. EFECTOS ADVERSOS DE LAS DROOAS Y CTROS AGENTES SOBRE EL FETO. (ADVERSE F 11454 EFFECTS OF DRUGS AND OTHER AGENTS ON Butler, N. R. and Alberman, E. D. THE FETUS.) Revista de Obstetricia THE EFFECTS OF SMOKING IN PRF)NANCY. yOinecologia-rePEenerrn7r-- In: Butler, N. R. and Alberman, E. D., r97 -228, 196C3'panieh (Abe.) (Editors). Perinatal Problems. Edinburgh and London, E. & S. Livingstone The role of maternal smoking has Ltd., 1969, pp. 7284. been included in this study on drugs. Varioua harmful effects have been attributed to maternal smoking: a F 11462 lower average weight of the fetus as Metres, H. compared with that of the controls; ZUR RAUCHERLEUKOKERATOSE. (SMOKERS' greater incidence of abortion; pre- LEUKOKERATOSIS.)Fortechritte der mature and still births, perinatal Kiefer-und Geeichtegerir51-6, mortality, fetal maceration, poet natal 1968 -bermaff-Onni77 pneumonia, and death by asphyxiation during labor; and a reduction in the Five cases of smoker's leUkokeratosis number of children and an increase in and leukoplakia are described.The mortality during childhood. Maternal etiological connection with smoking of smoking has also been held responsible improperly cured tobacco is discussed for stimulation of the smooth muscula- and the clinical and histological ture of the uterus iposeibly the cause features are described. In two patients, of premature births)). Women working in there were malignant changes in the mucous tobacco factories have been reported to membrane of the mouth and lips. have fewer pregnancies than controls, (Author Abstract) a higher abortion rate, and a higher rate of infant mortality. Paternal smo%Ang appeare to have ro effect on F 11467 the offspring. Schilli, W., Hamann, W., and Oehlert, W. DIE AUFNAB1E RADIOAKTIV MARKIERTEN KARZINGGENS IN DER MUNDSCHLEIMHAVr. F 11395 (THE UPTAKE OF RADIOACTIVE-LABF1ED Zackler, J. CARCINOGENS IN MOUTH MUCOSA.) ANTENATAL CARE. Current Therapy : Fortachritte der Kiefer-wid Gesichte- 773-80, 1969. gFIFUMVI3:277-3T7-1T687-se-Fin-Tne.)

237 P 11467 (continued) P 11473 (continued) hypophysis and the adrenal glands. The origin of this investigation Dysfunction of the hypophysis-adrenal was the observation that there is no system aide the progression of dystrophic increase in the frequency of carcinoma changes in the gastric mucosa and qf the mouth in smokers. The mucoua modifies the reactivity of its secretory membrane of the mouth was therefore apparatus, helping the development of investigated with respect to its mode peptic ulceration. (Author Abstract) of regeneration and its absorption of a carcinogen (benzpyrene).Observations on regeneration using radioactive P 11490 thymidine showed no difference compared Clett, J. A. and Itil, T. M. with external skin.On the other hand, QUANTITATIVE ELECTROENCEPHALOGRAM IN it was found that radioactive 3,4- SMOKING AND SMOKING DEPRIVATION. benzpyrene penetrated only into the Science 164(3882):969-70, May 23, 1969. auperficial layers of the mucoaa of the mouth, in contrast to its effect on skin. (Author Abstract) F 11512 Jiraseki V., Cerny, M., and Gregor, O. A CONTRIBUTION TO THE GENETIC PROBLEMS F 11469 OP ULCER DISEASE.Plzenoky Lekareky Stucchi, G. F. Sbornik (Suppl 22):161-7, 1968. ALCUNE CONSIDERAZIONI CLINICHE SULLE PARINOTTI IPERURICEMICHE. (SOME CLINICAL CONSIDERATIONS ON HYPERURICEMIC F 11513 PHARYNGITIS.) Annali di Laringologia, Vesely, K. T. and Kubickova, Z. Otologia RinolorrmranhgoiogIn 67(5): PARTICIPATION OF GENETIC AND NON-GENETIC 674-80, Feb 5, 1969, Italian (Abs.) FACTORS IN THE AETIOPATHOGENESIS OP PEPTIC ULCERATION.Plzensky Lekars The author reports the results of a Sbornik (Suppl 22):169-73, 19 . study made on some cases of chronic pharyngitis in hyperuricemic individuals. An investigation is made on the clinical F 11517 and etiopathogenetic characteristics Journal of the American Medical of this disease in the light of Association. modern knowledge.Living habits appear SMOKING INTERFERES WITH ABILITY TO to influence the occurrence of chronic UTILIZE VITAMIN C.Journal of the hyperuricemic pharyngitis. Plethoric American Medical Assnalann subjects, heavy eaters and drinkers 208(41:62677W28, 1959. are mainly affected. Smoking also acts as an exogenous causal factor. P 11540 Brief remarks on the treatment are also Gaultier, M., Fournier, E., Frejaville, included. J.-P., Nicaise, A. -M., and Bismuth,C. DIURESE FORCES (DIURESE OSMOTIQUE) DANS L'INTOXICATIQN AIOVE. P 11473 (FORCED DIURESIS `OSMOTIC DIURESIS) Mosin, V. I. IN ACUTE POISONING) Journal de 0 NWCACTEM 110,8402-4WPARNTIOLEmmg B Medecine et de ChirurirrIrgetrUes nATO1E1E3EA36ID+01 MEMO. 14013j:99:W7 Peb 1969, renc (Abs.) 0 ROLI SISTEMY GIPOPIZ-KORA NADPOCHECHNIKCV V PATOOENEZE YAZVENNOY Results of forced diuresis in a BOLEZNI. (ROLE OP HYPOPHYSIS - hospital handling more than 800 cases ADRENOCORTICAL SYSTEM IN THE PATHOGENESIS of acute poisoning were reported.In 9F ULCEPS.) Terapevticheekii Arkhiv 41 82 percent of the cases, filtering (2):27-::0, Feb 1969-, Russian (A177)-- off the poison la exclusively or preferentially renal and the evolution The author studied spontaneous has been transformed by theintroduction excretion of 17-oxycorticosterolds and of forced diuresis in the therapeutic 17-ketosteroids in the urine prior to techniques.This represents a progress and after administration of 40 units of analogous to the advent of assisted ACTH in 82 patients with gaatroduodenal ventilation in toxic comas. This per- ulcer. In 40 of them ACTH in the blood mits a reduction of two - thirds of was titrated. Re found that during the the acute stage of the intoxication period of exacerbation spontaneous and the results are sufficiently excretion of ateriod metabolites in the constant and reproducible todayto majority of patients is decreased, while permit affirmation of its lackof the blood ACTH is raised, which points danger and to systematize the to functional dissociation between

238 F 11540 (continued) F 11678 modalities. It was postulated that Pleasants, F., Jr., Grugan, J. and weak bases such as nicotine can best Ratliff J. W., Jr. be treated by urinary acidification. EFFECTS OF SHORT PERIODS OF ABSTINENCE The author maintains that forced FROM CIGARETTE SMOKING ON SWIMMING diuresis should not be feared as too ENDURANCE OF CHRONIC SMOKERS.Research difficult of surveillance, but that Quarterly 38(3):474-9, 1966. the method is simple and in indisputable fashion reduces the duration of toxic comas. F 11683 Tokuhata, 0. K. SMOKING IN RELATION TO INFERTILITY AND F 11563 FETAL LOSS. Archives of Environmental Goawami, B. M. and Barua, K. Health 17:353:77-S75-1978. SOME ASPECTS OF EPIDEMIOLOGY OF PEPTIC ULCER IN ASSAM.Journal of the Indian Medical Associati7MMT(7)Mr3,717-- F 11697 F, 1969. Haddon, W., Jr., Nesbitt, R. E. L., and Garcia, R. SMOKING AND PREGNANCY: CARBON MONOXIDE F 11572 IN BLOOD DURING GESTATION AND AT TERM. Gle!niger, J., Herms, 0., and Koelach, K. A. Obstetrics and Gynecology 18(3):262-7, DIE ATIOLOGIE DER LEBERZIRRHOSEN. rep 1961. (ETIOLOOY OF CIRRHOSIS OF THE LIVER.) Zeitschrift fur Arztliche Fortbildung 63(1):30-3, 701, 1959, Ge.arer) F 11760 Dahl, S. Etiology of cirrhosis of the liver VERSCHIEDENE INTRAKUTANTESTS was investigated in 250 patients. Causes AUSGEFUHRT BEI ALLERGICHEN other than alcoholic excess were hepatitis, ASTHMAPATIENTEN UND BEI NICHT- lack of dietary protein, diseases of the ALLERGIKERN. (VARIOUS SKIN bile duct, diabetes mellitus, gastroin- TESTS CARRIED OUT IN ALLERGIC testinal diseases, tuberculosis of the ASTHMA PATENTS AND EN NON. lung, and chronic inflammatory kidney ALLERGICS.1 Acta Allergologica diseases. Diseases of the bile duct 23(Suppl 9,:273=r, 235=7,-1666, accounted for the greater part of the German (Abs.) additional diseases or conditions in the patients. Bile duct diseases, in specific Allergic asthma patients and combinations with other diseases occurred non - allergies (alcoholics and in above-average frequency, so that one tubercular!) were divided into can juppose that they played a greater smoker and nonsmoker groups and role in the development of cirrhosis of their reactions to skin tests for the liver than previously thought.Only cigarette smoke and American to- rarely was there only one causative bacco noted. The number of non- disease in an individual. In many smoker subjects was too small for patients, aix or more liver-damaging valid conclusions regarding the diseasea, either prior to or accompanying teat results even though an ob- the cirrhosis, were presents two diseases vious difference existed. There were most frequent, with three also being were 4 to 5 times as many negative common. reactions in smokers as nonsmoker', regardless of whether the individuals were or were not allergies. F 11629 This excludea the poaaibility that McMurray, C. M., Moore, O. E., and nonsmokers avoid smoking since Vincent, R. they cannot tolerate tobacco or GINGIVAL BLEEDING AFTER CESSATION OF tobacco smoke. SMOKING. Journal of the American Medical Association 208(9)1T7U77 nn277077---- F 11783 Cotea, J. E. and Davies, C. T. M. F 11651 FACTORS UNDERLYING THE CAPACITY FOR Postgraduate Medicine. EXERCISE: A STUDY IN PHYSIOLOGICAL CIGARkrra SMOKING AND DURATION OF ANTHROPOMETRY. Proceedings of the PREGNANCY. Fogtgraduate Medicine Royal SSociety of medicine 727): 46(1):178-9, Jul 1969. 620-4, Jun 1647

259 245 F 11796 F 11861 (continued) Weary, P. E. and Wood, B. T. who had shown impressive results were ALLERGIC CONTACT DERMATITIS FROM now installed on placebos: 66 percent TOBACCO SMOKE RESIDUES. Journal of again reacted with renewed complaints the American Medical Association but the other 34 percent, both during Tinr(10):1905-7777-9, 1969. and after placebo treatment remained subjectively and objectively trouble- free. Whether this improvement could F 11822 be attributed to the drug or to the Foulds, W. S., Chisholm, I. A., Bronte- supportive treatment is subject to Stewart, J., and Wilson, T. M. interpretation. Tolerability to the VITAMIN B12 ABSORPTION IN TOBACCO drug in all cases was good. AMBLYOPIA. British Journal of Ophthal- mology 53(01=7 17=9. F 11870 Morozov, O. N. F 11835 De Wijn, J. F. nPonsopagoelOrOlEYEKIR clams-&( xpasinactioa,m0A3BaptOk VOEDING EN ZWANGERSCHAP. (NUTRITION OPYTPROTIVORETSIDIVHOG832MNIYA AND PREGNANCY.)Voeding 30(2):64-88, BOL'NYKH KHRONICHESKOY FORMOY YAZVENNOY Feb 15, 1969, Dutch (Abs.) BOLEZNI. (EXPERIENCE WITH PROPHYLACTIC TREATMENT OF PATIFNTS WITH CHRONIC FORMS Nutritional requirements of mother OF PEPTIC ULCERS.)Voenno-Meditsinskii and fetus were discussed. Smoking lnurnal (10):73-4, OTETT61, Russian during pregnancy can have a harmful effect on the expected offspring. 7517 Carbon monoxide by combining with the Experience is reported with 81 hemoglobin of the mother's blood can Heavy patients with ulcers of emotional reduce oxygen transport. stress origin who over a period of 5 smoking or nicotine can nr.rrow the years were given twice a year a course capillaries of the blood vessels of prophylactic dietary and medical interfering with the exchange of treatments. Of the 81 patients, 22 substances between mother and fetus. at various times suffered a worsening Investigations have shown that the of their condition. Smoking is offspring of smokingothers are mentioned as one of the contributory smaller and lighter in weight at birth causes to these relapses. than offspring of nonsmoking mothers, the degree of underdevelopment being proportional to the number of cigarettes Nicotine can be detected F 11872 smoked daily. Kapustnik, A. Ya. in the milk of heavy smokers and heavy cigarette smoking is therefore advised PEACI21A MEIVA00-6V2VE31.64PA3ANYKE against, but moderate smoking (and exupanaum. REAKTSIYA ZHELUDOCHNYKH ZHELEZ NA moderate intake of alcohol) may be RAZLICHNYYE RAZDAZHITELI. (REACTION permitted. OF THE GASTRIC GLANDS TO DIFFERENT IRRITANTS.) Voprosy Pitaniia 27(5): 90-1, Sep-Oct 1968, Ri13117:67TAbs.) F 11861 Straube, G. Healthy volunteers, age 20-25 years, UBER DIE BEURTEILUNG UND BEHANDLUNG ate fried fish (99 participants), a DES VERTIGO IN DER NEUROLCOISCHEN sauce made of onions, peppers, tomatoes PRAXIS. (EVALUATION AND TREATMENT and salt (18 participants) or smoked OF VERTIGO IN NEUROLOGICAL PRACTICE.) one cigarette (32 participants). Medizinische Welt 20i5:263-6, After a lapse of one hour, the stomach Yet) 1, 1969,,merman (Abs.) contents were removed and at hourly intervals thereafter, for a period of A brief description of the classic 5 to 6 hours, their gastric juices forma of vertigo was given.The were removed and tested for acidity, results of treatment with Monotrean (quinine hydrochloride and papaverine), hydrochloric acid content, and alkaline- acid coefficient. Smoking one cigarette a preparation that has been used had less irritant effect than the other together with roborants and the two irritants tested. elimination of chronic intoxication (alcohol, coffee, nicotine, barbiturates, etc.) was then reported. 72 F 11898 percent remained trouble -free after Younoszai, M. K., Peloso, J., and treatment and an additional 10 percent Haworth, J. C. were improved. Fifty of the patients FETAL GROWTH RETARDATION IN RATS EXPOSED

260 264 F 11898 (continued) F 11931 TO CIGARETTE SMOKE DURING PREGNANCY. Laszlo, V. American Journal of Obstetrics and A DOHANYZAS KAROS HATASAI A GESTATIOS owimenzirino7-13, Aug rT71969. FOLYAMATOKRA. (THE DELETERIOUS EFFECTS OF SMOKING ON THE SEQUENCES OF OESTA- TION.) Magyar Noorvosok Lapja 32(2): F 11699 163-7, MET17T971171.5117in lAbs.) U.S. Department of Health, Education, and Welfare, Public Health Service. The data interpreted on the deleteri- YOUR SMOKING AFFECTS TWO LIVES. ASK ous effects of smoking in terms of irreg- YOUR DOCTOR. U.S. Department of Health, ularities in menstruation, diminished Education, and Welfare, Public Health cycles of fertility, premature miscar- Service, Washington, Q. C., National riage; tardy menarche, menorrhagia, Clearinghouse for Smoking and Health. dysmenorrhea, conversely the detriment Public Health Service Publication No. numerically expressed, was also revealed 1923, May 1969, pp. 1-3. by the diminished number of viable sperms among smoking males.The study of hyperemesis and eclampsia during pregnan- F 11900 cy was also discussed,The increased Ludwig, A. M. and Pyle, R. L. incidence of premature birth (14.68 per- DANGER POTENTIAL OF COMMONLY ABUSED DRUGS. cent) contrasted with the diminished Wisconsin Medical Journal 68(6):216-8, physical weight of the offspring.The Jun 1969. relationship between stillbirth and smoking was also considered.The relationship between spontaneous miscarriage F 11911 versus the smoking habit of the conjugal Familiar, R. O. partner(e) as well as the quantity of SULFATE - CONTAINING GASTRIC MUCUS COMPONENTS cigarettes per diem smoked were studied AND PEPTIC ULCER: A POSSIBLE RELATION- in 155 case,. Though 20 percent of the SHIP. Journal of the American Geriatric pregnant subjects were nonsmokers, in 95 SocietyTirrrT6F547-jul 1969. percent of the cases they were constantly exposed to the deleterious effect of nicotine. The fetus must be considered a F 11919 paseive "smoker ". The results are sum- Ayres, S., Jr. and Mihan, R. marized in Table 1. As revealed by the TROPODERMATOSES--SKIN DISORDERS CAUSED BY Lorand tocograph, smoking is the causative STYLES, FASHIONS, CUSTOMS, AND HABITS. factor of uterus contractions of small Cutts 5(7):817-22, Jul 1969. amplitude on the muscular system of the womb. The cause of premature birth as a function of smoking was studied in 173 F 11926 cases. Only in two instances (1.1 per- Huber, A. cent) has the birth actually occurred at THERAPIE DER NEURITIS NERVI OPTIC/. the calculated date.The time deviation (THERAPY OF NEURITIS OF THE OPTIC from the calculated regular delivery as a NERVE.) Bibliotheca payshiatrirAa et function of smoking is also tabularly Neurologica (139), AktUT:Trel-PYKETn-aer presented. Psychiatrie and Neu77171177:313-S, 1969, Oerman-Ins. F 11958 Drug treatment and other therapeutic Spahr, U. and Voss, E. measures for neuritis of the optic nerve DIE FREIEN FETTSAUREN DES SERUMS-- of different etiologies were described. REOUIATIONSMECHANISMEN UND KLINISCHE The neuritis can also come about through BEDEUTUNG. (THE SERUM FREE FATTY various intoxicants, chief of which are ACIDS -- REGULATORY MECHANISMS AND nicotine and alcohol, causing the so- CLINICAL SIGNIFICANCE.) Zeitschrift called tobacco-alcohol amblyopia. fur Arztliche Fortbildun 63(5):245 -54, Methyl alcohol, lead, thallium, arsenic, WIT 1, 1969, German 11.) and even medicaments can bring about the neuritis. Elimination of the toxic sub- After a brief description of stance is the moat important step in essential fatty acid metabolic processes, therapy. In tobacco-alcohol neuritis, a review was made of the hormonal, and the administration of vitamin B complex the sympathetic- and metabolic regula- is most important since the condition tion of the fatty acid dynamics. The has resulted from a vitamin B deficiency. fatty acids released from adipose tissue by hydrolytic splitting of triglycerides represent the most important energy source of the organism

261 265 F 11958 (continued) F 12158 in the postabsorptive phase and in Oans, H., Sharp, H. L., and Tan, B. H. increased requirements.The fatty acid ANTIPROTEASE DEFICIENCY AND FAMILIAL content increases considerably, espe- INFANTILE LIVER CIRRHOSIS. Surgery, cially during hunger and long-continued Oynecology & Obstetrics 129(2):284-99, physical work as well as during pregnancy Aug1969. and adaptation proceases of the body. Under pathological conditions, the free fatty acids (FFA) can acquire signifi- F 12163 cance as insulin antagonists in diabetes Oreen, R. L. mellitus. The level of the concentration PEPTIC ULCER IN AIRLINE STEWARDS. permits insight into the difficulties Aerospace Medicine 40(8)1890-3, of metabolic decompensation of diabetics. Aug1v69. Obese individuals regularly show high FFA levels but their statue in the pathogenesis of this disorder can not as yet F 12179 be clearly defined. The hyperfunction of Oillies, M. A. and Skyring, A. the thyroid gland is an expression of the OASTRIC AND DUODENAL ULCER. THE catabolic effect of the thyroid hormone ASSOCIATION BETWEEN ASPIRIN INOESTION, on the adipose tissue with increased SMOKING AND FAMILY HISTORY OF ULCER. liberation and oxidation of the fatty Medical Journal of Australia 2(6)1280-5, acids. Nicotine causes a rapid and high 1717617 rise of FFA in blood plasma. F 12198 F 11981 Thyreeson, N. Beide, M., McIntyre, J. A., and Deitel, M. STOMATITIS APHTOSA.Kommentsrer Till en PEPTIC ULCER IN CHILDREN AND Frage om Afte och Rokningar. (APHTHAUS ADOLESCENTS. A Review of 28 Cases. STOMATITIS. Commentary to a Question Archives of Surgery 99(1 ):15 -8, of AO:the and Smoking.)Lakartidningen Jul 1969. 66(13i:1348-50, Mar 26, 1769, Swedieh (Abs.

F 12009 Inflammation of the soft tissues of Dragstedt, L. R. the mouth is rather widespread, according THE ROLE OF VAGOTOMY IN THE SUROICAL to literature aources.Its recidivity is TREATMENT OF PEPTIC ULCERS. Inter- known and prior to puberty the incidence national Surgery 52(2):79-89,-nr is greater in males, while after puberty more females are affected. Tetracycline, acromycin, and aureomycin, as well as corticosterolds are recommended as F 12032 therapeutic agents.Smoking is often a Spicer, S. S. and Sun, D. C. H. causative agent, or at least it Is an HISTOCHEMICAL AND MOkPHOLOGIC CHANGES IN aggravating factor to aphthous GASTRIC MUCOSA OF DOGS ON ULCEROGENIC stomatitis. After cessation of smoking, REGIMEN. American Journal of Pathology a dramatic recovery may be seen in 56(1):129-bl, Jul17;17 patients. Medical opinion on the influence of smoking is augmented by extracts from two case histories. F 12136 Paffenbarger, R. S., Jr., King, S. H., and Wing,A. L. F 12208 CHRONIC DISEASE IN FORMER COLLEGE STU- Ansorg, R. and Wuet, H. DENTS. IX. Characteristics in Youth HAUTERSCHEINUNOER BEI LEBERKRANKHEITEN. That Predispose to Suicide and (SKIN PHENOMENA IN LIVER DISEASES.) Accidental Death in Later Life. American Aretlichepraxis im Bild (6)1117-27, Dec Journal of Public Health and the al, 1968, Dermen-tAVKT RATErralteaTER-5915)1900:17 1751969. A pictorial presentation is given in regard to changes and symptoms noted in F 12153 the skin for a variety of liver diseases. Watson-Williams, E. J., Bottomley, A. C., The cases shown also include incidents Ainley, R. 0., and Phillips, C. I. Which are not truly liver diseases, such ABSORPTION OF VITAMIN B-12 IN TOBACCO as the occurrence of spider-shaped nevus AMBLYOP1A. British Journal of during pregnancy. The bulk of the pres- Ophthalmology 53(8):549-52, nig 1969. entation deals with true liver diseases

262 F 12208 (continued) F 12218 such as angloma formation in Osler's Kubacki, A. diseases, the erythema of the palm in ELEMENTY PSYCHOFIZIJOLOGICZNE W liver cirrhosis, and skin drawing noted PATOGENEZIE CHOROBY WRZODOWEJ. in the case of the Budd-Chlari syndrome. (PSYCHOPHYSIOLOGICAL ELEMENTS IN THE Often the liver is only indirectly re- PATHOGENESIS OF ULCERS.) Polski sponsible for changes of the skin since Tygodnik Lekareki 24(6):21=7-Feb 11, in certain chronic liver diseases the 1969, Polish Abs.) patient suffers from an itch, and scratches himself constantly which might The relationship between emotions and lead to a lichen infection of the skin. disease is mentioned in this literature review of 27 references. The effects of stress and emotional health were observed F 12210 in the behavior of laboratory animals. Lange, D. and Plagmann, H.-C. The ulcer personality in humans is DIAGNOSTIK UND THERAPIE VON ZUNGEN- briefly outlined, and this affliction VERANDERUNGEN UND ZUNGENERKRANKUNOEN. (including ulcers of the digestive tract) (DIAGNOSIS AND THERAPY OF TONGUE is classified as a psychosomatic disease. ALTERATIONS AND TONGUE DISEASES.) Emotions are considered as capable of Tag"Wt Praxis 10(0:27-42, 1969, destroying the immunological mechanism of GrirmaABI71 the body and the body may degenerate into a limbic aystem which expresses itself in Smoker's tongue is described, a particular "body languageTM. The together with several other physiological ulceration will be amenable to cure once changes of the tongue, ouch as the patient ie convinced that he should macroglossia, varices, heterotopias, avoid stresses resulting in emotions that keratoses, and geographic tongue.For disturb his hormone balance. all theses maladies, the etiology and clinical pictures are presented graphically. In addition, ailmente F 12220 such as tongue changes in the case of Schirren, C. and Gey, G. liver cirrhosis, and diseasee that are DER EINFLUSS DES RAUCHENS AUF DIE not true tongue diseases, are described. FORTPFLANZUNGSFAHIGKEIT BEI MANN UND Treatment and prognosis are outlined for FRAU. (THE INFLUENCE OF SMOKING ON each disease and/or symptom mentioned. THE REPRODUCTIVE ABILITY OF MEN AND WOMEN.) Zeitschrift Cur Haut and Geschlechts-xrankheitira(57175.-82, F 12214 ;tar 1, 1969,8175R-rne.) Pingerland, A. OVLIVNUJE KOURENI CIGARET NEPRIZNIVE Animal experiments have shown that PLICNI TUBERKULOZU? (DOES CIGARETTE reproductive ability becomea impaired in SMOKING HAVE AN UNFAVORABLE EFFECT ON males and females end that there ie TUBERCULOSIS CF THE LUNG?) Rozhled damage to the fetus, litters are smaller, v Tuberkulose a v Nemocech PI cn cs] and testicles atrophy. Since similar lab nup494, Aug-116 m:mm 7617"-- oratory experiments are nit possible with humans, a statistical evaluation The author has commented, in a letter, was undertaken of various features on the incidence of tuberculosis in (frequency of miscarriage in smoking Hesse, as presented by Dr. Wilhelm and nonsmoking women and the birth Lukas in a meeting of the Czech weight of babies). Secondary influences Pneumological and Phthisological were also taken into accounts the effect Society which was held in Prague on of smoking upon the milk of lactating April 5 1968.The incidence of women. Symptoms of oligospermia and tuberculosis of the lung in hypozoospermia were investigated in Czechoslovakia is also very high in men men in connection with smoking.Con- and women and, as in Hesse, much higher clusions are drawn that women during in men than in women. Causes for the pregnancy should not smoke at all sine high incidence and mortality had not nicotine ie found in the cervical been explained by Dr. Lukas. The author, secretion and in other parts of the body, mindful of the wellknown association of including the fetus.Once a man shows smoking and lung cancer, has suggested a signs of aub-normal fertility, he may be similar epidemiological and statistical advised to stop smoking. investigation of tuberculosis of the lung in smokers and nonsmokers.

263 F 12234 F 12333 Chapman, B. L. and Duggan, J. M. Mehta, F. S., Dartary, D. K., Shroff, ASPIRIN AND UNCOMPLICATED PEPTIC B. C., and Sanghvi, L. D. ULCER. Gut 10(6):443-50, Jun 1989. CLINICAL AND HISTOLOGIC STUDY OF ORAL LEUKOPLAKIA IN RELATION TO HABITS. A Five-year Follow-up. F 22237 Oral Surgery, Oral Medicine and Lennard-Jones, J. E. EFIT Pathology723r3,:372-68,77P MEDICAL TREATMENT OF PEPTIC ULCER. Medical Review 1(7)17-8, Jul 1969.

F 12334 F 12264 Fischman, S. L. Lennard-Jones, J. E. FOCAL EPITHELIAL HYPERPLASIA. PEPTIC ULCERATION. Journal or the Royal Oral Surgery, Oral Medicine and Naval Medical Service 55(2ra7'9721., PatEbrogy-nr37Y337:73,-Tep 3-ia:ir79707- TtAT.

F 12273 F 12358 McCoy, K. E. M. and Weswig, P. H. Cwiklicka, A. SOME SELENIUM RESPONSES IN THE RAT NOT UJEMNE URAZY EMOCJONALNE W DZIECINSTWIE RELATED TO VITAMIN E. Journal of I W WIEKU MLODZIENCZYM, A POZNIEJSZE Nutrition 98(4):383-9, m97 ZACHOROWANIE NA CHOROBE WRZODOWA DWUNASTNICY. (ADVERSE EMOTIONAL INFLUENCES IN CHILDHOOD AND ADOLESCENCE F 12286 AS RELATED TO LATER DEVELOPMENT OF Dunphy, E. B. CHRONIC PEPTIC ULCER.) Polski Tygodnik ALCOHOL AND TOBACCO AMBLYOPIA: A Lekarski 24( 2):1228-30,-177711, 1959, HISTORICAL SURVEY.XXXI DeSchweinitz Polish (Abs.) Lecture. American Journal of Ophthalm- ology 68(4):569:78, Oct-19637 The author discusses the importance of psychic trauma in childhood and adolescence in the pathogenesis of F 12298 psychosomatic illnesses, part.tcularly Roland, C. G. duodenal ulcer.Out of 40 studied PEPTIC ULCER. Archives of Internal patients with this disease in 36 cases Medicine 124(1)7077n7 717170177-- e history of very strong'and long-lasting psychic trauma connected with a feeling of helplessness and danger was given. F 12301 In 25 cases these emotional factors Journal of the American Medical Association. began to operate from the age of 9 years, STUDY EXPLAINS POST-SMOKERS' POUNDS. in further 11 cases these factors Journal or the American Medical occurred about the age of 15 years. tistri=eirt17n61791TrliTt717:273717 15, 1969. Most frequently these emotional factors were due to war or to quarrels b&tween parents. The results or these F 12304 studies seem to confirm the suggestion Neri, A. and Eckerling, B. of the author that duodenal ulcer is INFLUENCE OF SMOKING AND ADRENALINE most frequently a result of neurosis due (LPINEPHRiNE)ONTHEUTEROTUBAL usually to psychic trauma suffered in INSUFFLATION TEST (RUBIN TEST). early childhood. (Author Abstract) Fertility and Sterility 20(5): 618-25, Sect 1969. F 12359 Sarnowska, I. F 12312 ZMIANY W PRZYZEBIU W DOSWIADCZALNEJ Henry, J. P. and Cassel, J. C. MARSKOSCI WATROBY. (CHANGES IN THE P3YCHOSOCIAL FACTORS IN ESSENTIAL PARADONTIUM IN EXPERIMENTAL LIVER HYPERTENSION. RECENT EPIDEMIOLOGIC CIRRHOSIS.) Poznanskie Towarzyetwo AND ANIMAL EXPERIMENTAL EVIDENCE. Prz aciol Nauk W dy relcarski Prase American Journal of EiptLiolut edYEkEy Oo sw adczaTilej 3TTITT- 90(3):171-201: sera . Polfsb (Abs-T F 12359 (continued) F 12420 Mapper, N. 0., Black, L. F., Gleich, The author observed the pathologic G. J., and Kueppera, F. changes in the paradontium of 81 white THE PREVALENCE OF ALPHA-1-ANTITRYPSIN rats. Those changes appeared in the DEFICIENCY IN SELECTED GROUPS OF process of the experimental liver PATIENTSWITH CHRONIC OBSTRUCTIVE cirrhosis caused by Carbon tetra- LUNG DISEASE. Mayo Clinic Proceedings chloride and in the fatty degeneration 44(10)3697-710, 6ct11177 of the liver attained by feeding animals maize diet. The paradontium was examined by clinical, radiological and F 12448 microscopic methods. Microscopic Oaillard, A. examination of the livers and analysis LA OINOIVITE UICEREUSEtUNEMANIFESTA- of electrophoretic patterns of the TION GRAVE ET FREQUENTE DU TABAOISME. blood serum proteins were preformed. In (ULCERATIVE GINGIVITIS* A SERIOUS the Cully developed liver cirrhosis and AND FREQUENT MANIFESTATION OF NICOTIN- in its fatty degeneration there appeared ISM.) Inforgation Dentaire 50;4709- changes in all the tissues of the 16, Dec 12, 1968, French (Abs.) paradontium in the form of inflammation and atrophia, first of all, of the edge The etiology, pathology, diagnosis of the alveolar process, interdental and and therapy of ulcerative gingivitis interroot septa, and uncovering of the were described. Studies show that the tooth necks, loose teeth and falling out ulcerative gingivitis patient ie gener- of the teeth. In the fatty degeneration ally a heavy cigarette Smoker and one of the liver the pathologic changes in who inhales the smoke with inhalation of the paradontium were less marked than the smoke sometimes being of greater in the liver cirrhosis.The disappear- significance than the number of ciga- ance of the cirrhotic changes in the rettes smoked. Light smokers who inhale liver was always accompained by the or who live in a tobacco smoke atmo- inhibition of atrophic process in the sphere can also suffer severe intoxica- tissues of the paradontium. A correlation. Poor buccal hygiene doubtless tion was noticed between the exacerba- favors the development of the disorder. tion of the pathologic changes in the Absolute suppression of the tobacco paradontium and decrease of albumin habit ie en essential of therapy. level and increase of gamma-globulins in the blood serum. F 12465 Ferri-Pearee, D. and Denise, K. F 12391 CIRRHOSIS OF LIVER IN LAGOS INCLUDING Shah, D. R. and Singh, S. V. BROMSULPHTHALEIN RETENTION IN APPARENTLY PEPTIC ULCER AETIOLOGY AND PATHOOENESIS. NORMAL NIGERIANS.Ghana Medical Lcamia Journal of the Indian Medical 8(2)389-93, Jun 1907--- AirsTarertrOn-rgrrrrn-grAT-14,1969. F 12467 F 12415 Alli, A. F. and Lewis, E. A. Chapman, B. L. and Duggan, J. M. THE LIVER IN SICKLE CELL DISEASE- - ENVIRONMENTAL FACTORS AND THE PATHOLOGICAL ASPECTS I, BASED ON A REPORT AUSTRALIAN GASTRIC ULCER CHANGE. ON THE PATHOLOGICAL STUDY OF 77 NECROPSY Medical Journal of Australia 1 AND 5 BIOPSY SPECIMENS OF LIVER.Ghana (23) :117T-1373un 7,1969. Medical Journal 8(2)r119 -33, JunMr-

F 12417 F 12479 Schaefer, V. J. Aceto, M. D., Bentley, H. C., and Dembinski, SOME EFFECTS OF AIR POLLUTION ON OUR J. R. ENVIRONMENT, BioSeience 19(10) :896 - EFFECTS OF GANGLION BLOCKING AGENTS ON 7. Oct 1969. NICOTINE EXTENSOR CONVULSIONS AND LETHALITY IN MICE.Britia Journal of Pharmacology 37(1):1 - Sep 1960. P 12419 Foulde, W. S., Chisholm, I. A., Stewart, J. B., and Wilson, T. M. THE OPTIC NEUROPATHY OF PERNICIOUS ANEMIA. Archives f Ophthalmology 62(4)3427-32, Oct 1969. Rf265 F 12486 F 12603 (continued) Nebert, D. W., Winker, J., and Oelboin, consisted of a gastric mucous protector - H. V. dimethyl-polysiloxane. Excellent results ARYL HYDROCARBON KYDROXYLASE ACTIVITY were obtained in 13 of 17 cases of super- IN HUMAN PLACENTA FROM CIGARETTE ficial gastritis and in li of 16 cases SMOKING AND NONSMOKING WOW. Cancer of atrophic gastritis. blidarch 29(10)31763-9, Oct 1907---- F 12604 F 12561 Sorni, G. Weiss, W. LAS QC:BUTT'S. (CHEILITIS.)Medicine SMOKING AND HEARING LOSS. Presented Es ola 60(354)3144-9, Sep 191TT----- before the Epidemiology Section, pan s (Abs.) American Public Health Association, Philadelphia, Pa., Nov 11, 1969, The clinical aspects, etiology and 10 pp. treatment of four fundamental dermato- logical forms of cheilitis are described and include ecchymotic cheilitia, F 12603 chelitis glandularia, keratosic cheilitia, Ferrando Cucarella, J. and macrocheilitis.Etiological causes NUESTRA EXPERIENCIA EN EL DIAGNOSTICO I of ecchymotic cheilitis include mechanical TRATAMIENTO DE LAS GASTRITIS CRONICAS. factors such as lip biting and wetting, (OUR EXPERIENCE IN THE DIAGNOSIS AND atmospheric factors such as wind and TREATMENT OF CHRONIC GASTRITIS.) cold, chemical factors such as cosmetics, Ravista Espanola sle las Enfermedades and infectious factors such as strep- del Aparato DigesTivirff7(10):1497-501, tococcus and enterococcus. Mycosis and DgE 1968, gpanisE (Abe.) avitaminosis are other causes mentioned. Cheilitis glandularis is further broken In a study of 33 cases of chronic down into simple glandular cheilitia, gastritis, no correlation was found Baelz-Unna's cheilitis, and Volmann'e between atrophic gaatritis and age - apostematous cheilitia. Forms of practically the same proportion of cases keratosic cheilitis include lupus were found under 40 years as over 40 erythematosua, lichen ruber plenum, years. Gastritis was twice as prevalent leukoplasia, exfoliative cheilitis among men as women. The most frequent and abrasive cheilitis. In leukoplasia etiologic factor found for superficial of the lip, one of the caueea most gastritis was medications, followed by frequently encountered is tobacco, alcohol, coffee, tobacco, deficient especially on the form of cigarettes and mastication, condiments and spines, the manner in which they are smoked. psychic stress, and antecedents of acute The most susceptible smokers are those gastritis. As for atrophic gastritis, who hold the cigarette between the lips the moat common etiologic factor was de- and who smoke the cigarette almost ficient mastication followed by tobacco, to the end. coffee, medications, alcohol and condiments and spices. Generally, there was more than one etiologic factor in each F 12693 case studied, but there were also some Arasa, P. cases in which no etiologic factors were ETIOPATOOENIA DE LA ESCLEROSIS found. Symptoms of gastritis found MULTIPLE. (PATHOGENESIS OF MULTIPLE were, in order of frequency, SCLEROSIS.) Folia Clinics Internacional epigastric pain, acidity or pyroeie, 16(12):668-727775-'877Er=2, 665, Dec nausea, vomiting, anorexia, post- 1968, Spanish (Abs.) prandial engourgement, weight lose, intolerance of certain foods, meteorism, The autoimmunity hypothesis, infec- asthenia, regurgitation', hematemesie and tious theory and microembolic doctrine are melena. Except for epigaetric pain, discussed in relation to the etio- the physical examination was totally pathogenesis of multiple sclerosis. negative in all the patients studied. The microembolic doctrine is based on Although not useful itself in diagnosing the observation that many individuals gastritis, radiologic exploration can with multiple sclerosis seem to be eliminate other causes such as ulcers or unusually sensitive to the effects of diaphragmatic hernias. Gastric chamiam smoking. The smoke from a single has demonstrated a relation with the cigarette produces en accentuation of histologic picture. Gastric biopsy is the symptoms of multiple sclerosis. the moat effective method for diagnosing This phenomenon suggest' that in patients with multiple sclerosis previously gastritis. Treatment for all patients accustomed to tobacco there exists an

266 a. 70 F 12693 (continued) increasing sensitivity of the cerebral vasculature due to same vasoconstrictor substance such as nicotine. Other hypotheses with supporting and dis- proving evidence on the etiology of multiple sclerosis are discussed and include a lack of copper, potassium, magnesium or mercury; an alteration in blood level of pyruvic acid; cholesterol effect; a fat-rich diet; and a lack of linolenic acid. Several demyelinating disorders are described which at times have a similar syndrome and whose frame- works are undoubtedly polysclerosis. These include disseminated encephalo- myelitis, parainfectious encephalo- myelitis, Schilderis encephalitis, myelitis, concentric sclerosis and optic neuromyelitia.

F 12819 Alimovi V. A. and Kasymkhodzhaev, E. S. TOW0311na1Xat1 n0 rvamwm GDUCADIFKIWO OTAEAD4IJAK111VICTAGOCEHTCOrOWAITC11;CK000 kiCITITYTA 3A 2i1 PET (1948-1967). TSIRROZY FECHENI PO MATERIALAM SEETSIONNOOO OTDELENIYA KLINIK TASHKENTSOGO MEDITSINSKOGO INSTITUTA ZA 20 LET (1948-1967). (CIRRHOSIS OF THE LIVER ACCORDING TO TEE RECORDS OF THE AUTOPSY SECTION OF THE TASHKENT MEDICAL INSTITUTE CLINICS FOR 20 YEARS (1948-1967)0 Meditsinskli Zhurnal Uzbekistana 5:50-3, May InITITussian (Abs.) Analysis of 8760 autopsy Protocols for the years 1948-1967 showed 224 or 2.54 percent cases of cirrhosis of the liver (162 men and 62 women). Of these 224 canes, 182 were between the ages of 21 and 60 at time of death. The maximum mortality rates occurred in 1948 (3.05 Percent), 1957 (3.2 percent), 1959 (3.7 Perc67 ent, and 1966 (3.27 percent) and 19.83(3

See also A 10377, C 11868, C 12466, C 12533, C 12813

267 SECTION G. BEHAVIORAL RESEARCH

O 10208 Essman, W. B., Steinberg, M. L., and O 10639 Golod, M. I. Burns, B. H. ALTERATIONS IN THE BEHAVIORAL AND CHRONIC CHEST DISEASE, PERSONALITY, AND BIOCHEMICAL EFFECTS OF ELECTROCONVUL- SUCCESS IN STOPPING CIGARETTE SMOKING. SIVE SHOCK WITH NICOTINE. Ps'chonomic British Journal of Preventive & Social Science 12(3):107-8, 1968. FidrEERe 23(1)823=7, Feb 1969.

O 10274 O 10663 Morgan, K. R. Schwartz, J. L. and Dubitzky, M. REQUISITES FOR SUCCESS IN SMOKING LANDLORD FILL THE FLOWING FOWL. (AND WITHDRAWAL. In WHILE YOU'RE AT ITBRING ME A PACK OF Borgatta, E. F. CAMELS). Consultant 8(1):18-9, Jan and Evans, R. R. (Editors). Smoking, 1968. Health, & Behavior. Chicago, Ill., Aldine Publishing Co., 1968, pp. 231-47.

O 10302 O 10664 Eysenck, H. J. SMOKING AND PERSONALITY. Evans, R. R. and Borgatta, E. F. New Scientist A SMOKING DISSUASION EXPERIMENT AMONG 40(627)1633, Dec 12, 1968. UNIVERSITY FRESHMEN. In Borgatta, E. F. and Evans, R. R. (Editors). O 10343 Smoking, Health, & Behavior. Chicago, Ill., Aldine Publishing Co., 1968, Morrison, C. F. and Lee, P. N. pp. 220-30. A COMPARISON OF THE EFFECTS OF NICOTINE AND PHYSOSTIOMINE ON A MEASURE OF ACTIVITY IN THE RAT. Psychopharmacologia 13(3)8210-21, 1968. O 10665 Borgatta, E. F. and Evans, R. R. SOCIAL AND PSYCHOLOGICAL CONCOMITANTS O 10385 OF SMOKING BEHAVIOR AND ITS CHANGE AMONG Corley, K. C., Jr. UNIVERSITY FRESHMEN. In Borgatta, THE EFFECTS OF NICOTINE ON LEVER- E. F. and Evans, R. R. (Editors). Smoking, Health, & Behavior. Chicago, PRESSING BEHAVIOR IN CAT. Paper presented at Eastern Psychology Ill., Aldine Publishing Co., 1968, Association Meetings, Washington, PP. 206-19. D. C., Apr 1968, 15 pp. O 10667 Tomkins, S. O 10575 A MODIFIED MODEL OF SMOKING BEHAVIOR. Oliverio, A. Ins Borgatta, E. F. and Evans, R. R. EFFECTS OF SCOPOLAMINE ON AVOIDANCE (Editors). Smoking, Health, & Behavior. CONDITIONING AND HABITUATION OF MICE. Chicago, Ill., Aldine Publishing Co., Psychopharmacologia 12:214-26, 1968. 1968, pp. 165-86.

O 10588 O 10668 Oliverio, A. McKennell, A. C. EFFECTS OF NICOTINE AND STRYCHNINE ON BRITISH RESEARCH INTO SMOKING BEHAVIOR. TRANSFER OF AVOIDANCE LEARNINO IN THE In Borgatta, E. F. and Evans, R. R. MOUSE. Lite Sciences 7(22, Part 2)8 (Editors).Smoking, Health, & Behavior. 1163-7, 116Va, 1968. Chicago, Ill., Aldine Publishing Co., 1968, pp. 140-64. O 10632 Fybus, R. J., Goldfarb, T. L., and Jarvik, O 10669 M. E. Salber, E. J., Freer n, H. E., and A DEVICE FOR MEASURING CIGARETTE SMOKING Abelin, T. IN MONKEYS. Journal or the Experimental NEEDED RESEARCH ON SMOKING LESSONS FROM Analysis of BiErira 720788-00, Jan THE NEWTON STUDY. In Borgatta, E. F. 1969. and Evans, R. R. (Editors). Smoking, Health, & Behavior. Chicago, Ill., Aldine Publishing Co., 1968, pp. 128-39.

268 2 48., o 10671 O 11070 Zagona, S. V. Malcolm, A. I. STUDIES AND ISSUES IN SMOKING BEHAVIOR SOME BEHAVIOURAL ASPECTS OF DRUG DEPEN- RESEARCH: A SUMMARY OF THE ARIZONA DENCE. Canadian Journal of Public Health CONFERENCE. In: Borgatta, E. F. and 60(4)1139-63,APr19 W7 Evans, R. R. (Editors). Smoking, Health, & Behavior.Chicago, Ill., Aldine Publishing Co., 2968, pp. 88-94. a 11072 Savitt, R. A. THE ADDICTION TOINHALANTDRUGS AND G 10672 OHEKICALS. Asian Medical Journal 11(12): Mausner, B. 24-7, Dec 19 THE BEAVER COLLEGE CONFERENCE ON BEHAV- IORAL STUDIES IN SMOKING: A RETROSPEC- TIVE VIEW. In: Borgatta, E. F. and O 11081 Evans, R. R. (Editors). Smoking, Health, Clark, M. S. O. & Behavior. Chicago, Ill., Aldine SELF-ADMINISTERED NICOTINE SOLUTIONS Publishing Co., 1968, pp. 83-7. PREFERRED TO PLACEBO BY THE RAT. British Jpurnal of Pharmacology 38(2)f367P71Ki5-- 1869. a 10798 Bankart, C. P. and Lanzetta, J. T. DISS01,,NCE AND DESIRE FOR A CIGARETTE. O 11121 Psychological Reports 23(3, Part 2): Morrison, C. F. 1155-61, Dec 2968. THE EFFECTS OF NICOTINE ON PUNISHED BEHAVIOUR. PsychoPharmacologia 14(3)1 221-32, 1969. G 10641 Smith, G. M. PERSONLICHKEIT RAUCHEN. O 11122 (PERSONALITY AND SMOKING.) In Bovet-Nitti, P. Schievelbein, H. (Editor). Nikotin: FACILITATION OF SIMULTANEOUS VISUAL Phsrmakologi. and Toxikologie des DISCRIMINATION 8Y NICOTINE IN FOUR Tabakrauches.Stuttgart (West Germany), 'INBRED' STRAINS OF MICE. Psychopharma- Georg Thieme Verlag, 1968, pp. 75-81., cologia 14(3):193-9, 1969. Gerran (Abs.)

There was general agreement that O 11340 smokers were more extroverted than Johnson, J. H. nonsmokers. In the field of mental STEP TEST OF MOTIVATION TO EXCEL. health (nervousness, anxiety, neurotic Aerospace Medicine 40(4)1421-4, Apr tendencies, emotional disturbances, 1969. maladjustment and psychosomatic symptoms) nost investigators supported the conclu.ion that smokers had poorer O 11548 mental health than nonsmokers. In Oarg, M. other aspects, smokers were judged to THE EFFECTS OF SOME CENTRAL NERVOUS have more anti-social personality SYSTEM STIMULANT AND DEPRESSANT DRUGS traits. It would be misleading to ON REARING ACTIVITY IN RATS. conclude that there was strong support Psychopharmacologia 14(2)050-6, for the belief that smoking was not Feb 3,-1-969. causally linked with disease but it was correctly concluded that smokers and nonsmokers did not differ genetically.O 11484 There was r -h overlapping in the Battig, K. distribution of personality test THE EFFECT OF NICOTINE ON THE values of .smokers and nonsmokers. The SWINNING SPEED OF PRE-TRAINED RATS reliability of the determination of THROUGH A WATER ALLEY. Peychopharmacologia smoker habits on the basis of personal 15(0:19-27, )969. characterist'os was usually between 55 and 60 percent. It was concluded that the possl!le genetic significance of O 11555 personality differences between smokers Oarg, M. and nonsmokers must only cautiously VARIATION IN EFFECTS OF NICOTINE IN be offered. FOUR STRAINS OF RATS.Psychopharmacologia 14(5):452-8, 1969. G 11607 O 12195 (continued) Nasello, A. G. and Izquierdo, I. cigarettes as a reward, he was gradually EFFECT OF LEARNING AND OF DRUGS ON THE trained to voluntarily accomplish daily RIBONUCLEIC ACID CONCENTRATION OF living tasks such as getting up and BRAIN STRUCTURES OF THE RAT. EExxperimeenttal going to bed; doing his laundry, Neurology 23(0:521-8, Apr 196 . participating in training sessions and eating three meals daily.

O 11685 Wakefield, J. (Editor) O 12505 INFLUENCING SMOKING BEHAVIOUR.UICC Arbeitagemeinschaft fur Sozial-und Technical Report Series, Vol 3, Geneva, Wirtschaftsforrchung. Switzerland, Norwegian Cancer Society, JUGENDLICHE UND RAUCHEN. (TEENAGERS 1969, 90 pp. AND SMOKING.) Arbeitegemeinschaft fur Sozial-und Wirtschaftsforschung, Heidelberg, Feb 15, 1969, 47 pp., O 11686 German (Abs.) Jarvik, M. E. THB ROLE OF NICOTINE IN THE SMOXING The attitudes toward smoking and HABIT. Albert Einstein College of the posaibiliti:a of alterations of Medicine, 1969, 48 pp. those attitudes were investigated in 235 boys and girls, 12 to 18 years old, of different social strata, chiefly in the G 11691 urban areas of Berlin, Hamburg, Munich Horn, D. and Heidelberg.The reactions of the NEW CONCEPTS IN SMOKING EDUCATION. teenagers to two brochures, "What is Presented at the Biennial Meeting of Really True?", and "Peter's Leaflet the State & Territorial Directors of No. 1 were analyzed. These studies led Public Health Education, Jekyll Island, to the design of three posters intended Ga., Hoy 12-16, 1969, 18 pp. for application in antismoking campaigns in schools and elsewhere. The posters, each of which was prepared in two O 11698 slightly different versions, were McKennell, A. C. and Bynner, J. M. labeled, "Who needs Something Like That', SELF IMAGES AND SMOKING BEHAVIOUR AMONG "Smoking is Healthy", and "Money is a Fine SCHOOL BOYS. British Journal of Thing". The suitability of he posters Educatfonal PelraTIgy390970t7r): for the desired purpose was discussed. 27639, Feb 1969.

O 12E48 O 11887 Morrison, C. F., Goodyear, J. M., and Roberts, A. H. Sellers, C. M. SELF-CONTROL PROCEDURES IN MODIFICA- AWAGONISM BY ANTIMUSCARINIC AND TION OF SMOKING BEHAVIORfREPLICATION. OAMILION-BLOCKING DRUGS OF SOME OF THE Psychological Reports, 24(2):675-6, BEHAVIOURAL EFFECTS OF NICOTINE. Apr 1969. Psychoeharmacolomia 15(5):341-50, Oct IS, 19o9.

G :2195 Maruyama, T. Kameura, N., and Rikimaru, S. O 12549 TABAKO NO HOSHU 0 RIYO SHITA CO CHUDOKU Morrison, C. F. and Stephenson, J. A. KANJA NO SEIKATSU KVNREN NO KEIKEN. NICOTINE INJECTIONS AS THE CONDITIONED (EXPERIENCES IN THE REHABILITATION OF STIMULUS IN DISCRIMINATION LEARNING. PATIENTS WITH CARBON MONOXIDE POISONING Psychopharmacologia 15(5):351-60, USING CIGARETTES AS A REWARD.) Oct 13, 1969. Kan o ku Zasshi 33382-5, Feb 1969, apanese (KEW:7- O 12558 A case history is given of the rehab- Silverman, A. P. ilitation of a 38-year-old miner who was BEHAVIOURAL EFFECTS OP A "SMOKING involved in s mine accident and suffered DOSE' OF NICOTINE IN RATS.British from carbon monoxide poisoning. The Journal of Pharmacoloxy 37(2):506F- patient was unconscious for 10 days after 7P, OcE 1169. the accident and after recovering consciousness had marked apathy and a deterioration in his mental processes.The only desire he had was for cigarettes. Using O 12609 Garg, M. THE EFFECT OF NIcams ON TWO DIFFERENT TYPES OF LEARN/NO. 15(5)1408-14, 1439Psychooharmacoloxia

O 12714 Lic'etenstein, S., Keutzer, C. S.,and Nimes, K. H. "EMOT/OhALN ROLE- PLAYING AND CHANGES IN SMOKING ATTITUDES ANDBEHAVIOR. Reports 25(2)079-87, Octt 1.

O 12715 Parker, J. M. and Madill, H.D. A CLINICAL TRIAL STUDENTEXERCISE- - ACUTE TOBACCO WITHDRAWAL. UWO Medical Journal, 59(4)1110-2, 1969.

O 12757 Popham, R. E. TOBACCO PRICES AND ALCOHOLCONSUMPTION-- TEST OF A FOLK-HYPOTHESIS.British of &maim 94(0t219-21, Oct Journal.

12642 Platt, E. S., Krassen, E., and Mausner, S. INDIVIDUAL VARIATION IN BEHAPIORAL CHANGE FOLLCMING ROLE PLAYING. Psych/21699gical&Naga241155-70, 741119.

271 SECTION H. TOBACCO ECONOMICS

H 10241 H 11216 (continued) Medical World News. countries by 40 percent. The embargo on IS IT BECOMING COOL NOT TO SMOKE? the exportation of tobacco products from Medical World News 9(46)127, 19, Nov 15, Rhodesia may permit certain developing countries to penetrate the international market for "flue-cured" products. The number of smokers and per capita consump- H 10351 tion is increasing at the rate of 2 to 3 Tobacco Tax Council, Inc. percent per year. Smokers, preferences THE TAX BURDEN ON TOBACCO. The Tax are expected to be for a tobacco of good Burden on Tobacco, Historical Compila- quality with a low nicotine content. tion, Vol. 3.Richmond, Virginia, Tobacco Tax Council, Inc., 1968, 119 pp.

H 10483 Besse, D. H. (Editor). TOBACCO CONSUMPTION IN VARIOUS COUNTRIES. Tobacco Research Council, Research Paper No. 6. London, Eng., 1968, 64 pp.

H 10503 Hedrick, J. L. FACTS ON SMOKING, TOBACCO, AND HEALTH. Prepared under Contract No. PH 86 -67- 176 for the U. S. Department of Health, Education, and Welfare, Public Health Service, Resource Management Corpora- tion, Mar 1969, (Revised), 134 pp.

H 11215 Jornal do Medico. ACRESCIMO MUNDIAL DO CONSUMO DE CIGARROS. (INCREASE IN WORLD CONSUMPTION OP CIOAREWES.) Jornal do Medico 67(1325): 852, Dec 21, 1§717-7oFEUFFrolAbs.)

In spite of warnings by doctcrs, world consumption of cigarottes, especially filtered cigarettes, continues to rise. The 1967-8 production was 2,897 million units (cigarettes and cigars) as against 2,800 million in 1966-7, an increase or 2.5 percent. Manufacturers in 1967 required about 3,200 million kilos of tobacco, approximately 75 percent of world production of unproceased tobacco.

H 11216 Jornal do Medico. APESAR DE TCDAS AS CAMVANHAS CONTRA 0 TABACO, AUMENTA CONSTANTEMEN1E 0 CONSUMO DE CIGARROS. (THE CONSUMPTION OP CIGA- RETTES IS CONSTANTLY 1NCREASINO,DESPITE ALL THE ANTI-TOBA0C0 CAMPAIGNS.) Jornal do Medico 68(1360480, Feb 15, -96r7--- 76ATIg174 (Abs.)

An FAO study showed that developing countries are increasing their production of cigarettes by 50 percent an' developed

272 au, SECTION L BILLS AND LEGISLATION

I 10409 I 10661 Conover, A. 0. Meserve, W. G. THE DOMESTIC CONSUMPTION OF TOBACCO CONGRESSIONAL ACTION ON SMOKING AND PRODUCTS AND THE SMOKING-HEALTH HEALTH. In: Borgatta, E. F. and ISSUE. Presented at the Agricultural Evans, R. R., (Editors). Smoking, Economic Section of the 20TH National Health, & Behavior. Chicago, Ill., Tobacco Workers Conference, University Aldine Publishing Co., 1968, pp. 257-62. of Kentucky, Lexington, Ky., Jul 13, 1965, 17 pp. I 10749 Practitioner. I 10478 CIGARETTES AND LUNG CANCER. Brace, F. C. Practitioner 202(1207):A95, Jan PROHIBITION OF CIGARETTE ADVERTISING TOTO. ON TELEVISION. Michigan Medicine 67(26):57-8, Dec 1968. 1 10809 I 10479 Medical Officer. CIGARETTE SMOKING.Medical Officer Canadian Medical Association Journal. 120(24):356-7, Dec 13, 1968. HEALTH COMMITTEE TO STUDY CIGARETTE SMOKING BILLS. Canadian Medical Association JourEWT-0-675):24,.Dec I 10860 18, 1968. Tobacco. TOBACCO-STATE CONGRESSMEN MAP STRATEGY I 10564 TO COMBAT ANTI-SMOKING CAMPAIGN CORDES. Pennsylvania Pharmacist. Tobacco 268(13):18, Mar 28, 1969. F. C. C. RULING ON CIGARETTES UPHELD. Pennsylvania Pharmacist 50(6):14, Jan 1969. I 10956 Nebraska State Medical Journal. CIGARET ADS. Nebraska State Medical I 10581 Journal 54(3):165, Mar 1969. U. S. Federal Trade Commission. PURSUANT TO THE FEDERAL CIGARETTE LABELING AND ADVERTISING ACT. U. S. I 10975 Federal Trade Commission Report to U.S. Medicine. Congress, Washington, D. C., Jun SO, BILL BLOCKS CIGARETTE AD BAN. U.S. 1968, 62 pp. Medicine 5(6):17, Mar 15, 1969.

I 10989 I 10650 Journal of the Mississippi State Medical AMA News. Association. AMA News CIGARET AD BAN HEARINGS NEAR. ASH: MILD LABEL FOR A SINGEING 12(6):10, Feb 17, 1969. MOVEMENT. Journal of the Mississippi State Med1c1IXiTicritrg 140(3):99-100, I 10653 Medical Journal of Australia. CIGARETTE SMOKING. Medical Journal of Australia 2(2011158-9,-Dec 21,1968. I 11119 Lancet. ROUND THE WORLD. U.S.A. Lancet 1(7594)1 I 10660 567-8, Mar 15, 1969. Herron, H. R. SOCIOECONOMIC EFFECTS OF INCREASING I 11233 STATE CIGARETTE TAXES.In norgatta, Journal of the Tennessee Medical E. P. and Evans, R. R., (Editors). Association. Smoking, Health, & Behavior. Chicago, NATIONAL NEWS. Journal of the Tenneseee Ill., Aldine Publishing Co., 1968, Medical AseociatIon 62(STr25r4776-7- pp. 263-6. iTT77-m

273 0277 I 11239 I 11399 Rhode Island Medical Journal. U.E. House of Representatives, 91st TER WASHINGTON SCENE.Rhode Congress, let Session. Island Medical Journal Mr: PART 3: CIGARETTE LABELING AND rsrzr; ADVERTISING-1969.Hearings before the Committee on Interstate and Foreign Commerce House of Representatives. House I 11322 of Repreaentativee Bill H. R. 643, 1237, Kennedy, R. F. 3065, 6543, Apr 15-18, 21-25, 28-30, May GOVERNMENTAL ACTION TO CONTROL 1, 2969, pp. 393-1420. CIGARETTE ADVERTISING AND OTHER ASPECTS OF THE PROBLEM. Speech CelivAJred at the World Conference on I 114CG Smoking and Health, Sponsored by the Carter, L. J. National Interagency Council on SMOKING AND HEALTH, CLOSING THE RING ON Smoking and Health, New York, N.Y., THE CIGARETTE. Science 164(3865)' Sep 11-13, 1967, pp. 4-13. 1238-61, Jun 13,77677

I 11333 I 11447 Foote, E. Scuth Dakota Jsurnal of Medicine. WHAT MIGHT BE DONE TO CURB CIGARETTE THE MONTH IN WASHINGTON. South Dakota ADVERTISING. Speech delivered at the Journal of Medicine 22(4):Mr7 UF--- World Conference on Smoking and Health, Sponsored by the National Interagency Council on Smoking and Health, New York, N.Y., Sep 11-13, 1967, pp. 243-9. I 11453 Medical Journal of Australia. LUNG CANCER, Medical Journal of I 11396 Australia 1(11111.557A7777-1779. U.S. House of Representatives, 9let Congress, let Session. PUBLIC HEATH CIGARETTE SMOKING ACT OF I 21455 1969. REPORT TOGETHER WITH ADCITIONAL AMA News. AND MINORITY VIEWS.. (To Accompany H. R. REQUIRED CIGARET WARNINGS PROPOSED BY 6543) U.S. House of Representatives, ?CC CHAIRMAN. AMA News 12(16):3, 91st Congress, let Session, Report No. Apr 28, 1969. 91-289. Jun 5, 1969, 40 pp. I 11488 I 11397 Cunningham, J. U.S. House la representatives, 91st IMPERIAL TOBACCO HEAD MAKES STRONG PLEA Coi,sress, let Session. TO OFFSET CANADIAN SMOKING-HEALTH ISSUE. PART 1: CIGARETTE LABELING AND Tobacco 168(25):48, Jun 20, 1969. ADVERTISING- -1969. Hearings before the Committee on Interstate and Foreign Commerce, House of Representatives. I 11514 House of Representatives Bills H. R. U.S. Medicine. 643, 1237, 3065, 6543, Apr 15-18, CIGARETTE WARNING PLEA MADE. U.S. 21-25, 28-30, May 1, 1969, 452 pp. Medioine 5(9):6, May 1, 1969.

I 11398 I 11554 U.S. House of Representatives, 91st Moore, G. E. Congress, let Session. PRACTICAL CONTROL OF SMOKING HAZARD. PART 2: CIGARETTE LABELING AND New En land Journal of Medicine 281 ADVERTISING--1969. Hearings before the rn: , u -17-11%77 Committee on Interstate and Foreign Commerce House of Representatives.House of Representatives Bills H. R. 643, 1237, I 11580 3055, 6543, Apr 15-18, 21-25, 28-30, Mandel, P. R. May 1, 1969, p). 453-892. STATEMENT ON FEDERAL CIGARETTE LABELING AND ADVER1ISING ACT.Nassau Medical News 41(5):6, 8, 11, mirrno.

274 aic I 11587 I 11703 (continued) AMA News. of Canada, 28th Parliament, let Session, CIOARET ADVERTISING TESTIMONY CONFLICTS. No. 17, Feb 18, 1969, pp. 487-541. AMA News 12(18):11, May 12, 1969.

I 11704 I 11623 House of Commons of Canada, 28th Greenwald, F. and Sherman, C. D., Jr. Parliament, let Session. TOBACCO LEGISLATION. (Special Article) STANDING COMMITTEE ON HEALTH, WELFARE New York State Journal of Medicine AND SOCIAL AFFAIRS. House of Commons Mrs173T1=r-gairTS7-IVM of Canada, 28th Parliament, 1st Session, No. 18, Feb 20, 1E69, pp. 543-600. I 11625 AMA News. CIOARST PACKAGE FIGHT CONTINUES.AMA I 11706 News 12(22):7, Jun 9, 1969. House of Commons of Canada, 28th Parliament, 1st Seardon. STANDING COMMITTEE ON HEALTH, WELFARE I 11L'il AND SOCIAL AFFAIRS.House of Commons Bulletin of the Lancaster City and County of Canada, 26th Parliament, lst Session, Medical Society. No. 19, Feb 25, 1969, pp. 601-46. CIGARETTE HEARINGS NEXT WEEK...Bulletin of tne Lancaster City and CountReolcai 3`LEML54(10-:247751-TT6 . I 11706 House of Commons of Canada, 28th Parliament, 1st Session. I 11689 STANDING COMMITTEE ON HEALTH, WELFARE U.S. Federal Trade Commission. AND SOCIAL AFFAIRS.House of Commons of REPORT TO CONGRESS PURSUANT TO THE Canada, 28th Parliament, lat Session, FEDERAL CIGAR? TTL LABELING AND ADVERTISING No. 20, Feb 27, 1969, pp. 647-98. ACT. U.S. Federal Trade Commission Report to Congress, Washington, D. C., Jun 30, 1969, 56 pp. I 11707 House of Commons of Canada, 28th Parliament, lst Session. I 11700 STANDING COMMITTEE ON HEALTH, WELFARE House of Commons of Canada, 28th AND SOCIAL AFFAIRS.House of Commons of Parliament, 1st Session. Canada, 28th Parliament, lst Session, STANDINO COMMITTEE ON HEALTH, WELFARE No. 24, Apr 21, 1969, pp. 849-82. AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, let Session, No. 9, Dec 19, 1968, pp. 127-55. I 11708 House of Commons of Canada, 28th Parliament, let Session. I11701 STANDING COMMITTEE ON HEALTH, WELFARE House of Commons of Canada, 28th AND SOCIAL AFFAIRS.House of Commons Parliament, let Session. of Canada, 28th Parliament, let Session, STANDING COMMITTEE ON HEALTH, WELFARE No. 26, Apr 24, 1969, pp. 917-48. AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, 1st Session, No. 10, Jan 16, 1969, pp. 157-78. 1 11709 House of Commons of Canada, 28th Parliament, lst Session. I 11702 STANDING COMMITTEE ON HEALTH, WELFARE House of Commons of Csnada, 28th AND SOCIAL AFFAIRS.House of Commons of Parliament, 1st Session. Canada, 28th Parliament, lst Session, STANDING COMMITTEE ON HEALTH, WELFARE No. 28, Apr 29, 1969, pp. 973-100e. AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, lst Session, No. 15, Feb 6, 1969# pp. 423-50. I 11710 House of Commons of Canada, 28th Parliament, let Session. I 11703 STANDING COMMITTEE ON HEALTH, WELFARE House of Commons of Canada, 28th AND SOCIAL AFFAIRS.House of Commons Parliament, lst Session. of Canada, 28th Parliament, let Session, STANDING COMMITTEE ON HEALTH, WELFARE No. 50, May 1S, 1969, pp. 1063-124. AND COCIAL AFFAIRS.House of Commons

275 2.19 I 11711 I 11718 (continued) House of Commons of Canada, 28th Canada, 28th Parliament, tat Session, Parliament, let Session. No. 40, Jun 9, 1969, pp. 1773-93. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, 1st Session, I 11719 No. 31, May 15, 1969, pp. 1125-60. House of Commons of Canada, 28th Parliament, let Seseion. STANDING COMMITTEE ON HEALTH, WELFARE I 11712 AND SOCIAL AFFAIRS.House of Commons of House of Commons of Canada, 28th Canada, 28th Parliament, let Session, Parliament, lat Session. No. 41, Jun 12, 1969, pp. 1795-859. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, 1st Session, I 11720 No. 32, May 20, 1969, pp. 1161-238. House of Commons of Canada, 28th Parliament, 1st Session. STANDING COMMITTEE ON HEALTH, WELFARE I 11713 AND SOCIAL AFFAIRS.House of Commons of House of Commons of Canada, 28th Canada, 28th Parliament, 1st Session, Parliament, 1st Session. No. 42, Jun 16, 1969, pp. 1861-98. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS.House of Commons of Canada, 28th Parliament, lat Sessicn, I 11721 No. 33, May 22, 1969, pp. 1239-346. House of Commons of Canada, 28th Parliament, let Session. STANDING COMMITTEE ON HEALTH, WELFARE I 11714 AND SOCIAL AFFAIRS. House of Commons of House of Commons of Canada, 28th Canada, 28th Parliament, 1st Session, Parliament, let Sesaion. No. 43, Jun 17, 1969, pp. 1899-949. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS. Houae of Commons of Canada, 28th Parliament, 1st Sessivn, No. I 11722 34, May 26, 1969, pp. 1347-87. House of Commons of Canada, 28th Parliament, let Session. STANDING COMMITTEE ON HEALTH, WELFARE I 11715 AND SOCIAL AFFAIRS.House of Commons of House of Commons of Canada, 28th Canada, 28th Parliament, let Session, Parliament, let Seasion. No. 44, Jun 19-25, 1969, pp. 1951-2058. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS. House of Commons of Canada, 26th Parliament, 1st Sesaion, I 11845 No. 35, May 27, 1969, pp. 1389-430. Gramignani, V. LA TUTELA DELLE MALATTIE PROPESSIONALI NEI PAESI ADERENTI AL NEC. (PROTECTION I 11716 AGAINST OCCUPATIONAL DISEASES IN House of Commons of Canada, 28th COUNTRIES OF UM EUROPEAN MARKET.) parliament, lst Session. Minerva Medic& Sicilians 13 3):278-81s STANDING COMMITTEE ON HEALTH, WELFARE =MI5 171:17Itallan (As. AND SOCIAL AFFAIRS. House of Commons of Canada, 28th Parliament, let Session, Uniform protection relative to No. 36, May 29, 1969, pp. 1431-84. occupational diseases under the Social Security systems has been a goal of the European Economic Community. A "European" 1 11717 list had bsol presented by a study group House of Commons of Canada, 28th of the E.S.C. in 1962 and additions to Parliament, 1st Session. the list had subsequertly been made. The STANDING CO.14ITTEE ON HEALTH, WELFARE general provisions of the European list AND SOCIAL AFFAIRS. House of Commons of have beer. compared with the Italian list. Canada, 28th Parliament, lat Session, Adoption of the preaently proposed No. 38, Jun 5, 1969, pp. 1537-6b9. standards is regarded only as a first step toward furnishing protection to indi*iiusle regardless of where they I 11718 reside. Tobacco was not covered except Houle of Commons of Canada, 28th for the statement that nicatiniem lie en Parliament, let Session. occupationL1 disease was given status STANDING COMMITTEE ON HEALTH, WELFARE only in certain tobacco workers in the AND SOCIAL AFFAIRS. House of Commons of Low Countries.

276 0 $0 I 12116 I 12839 Goldstein, D. N. U.S. Senate, 91st Congress, let Session. BIG MONEY VS PUBLIC HEALTH. Wisconsin PUBLIC HEALTH CIGARETTE SMOKING ACT Medical Journal 68(7):35-6, Jul 196W. OF 1969. Report submitted by Mr. Magnuson, from the Committee on Commerce, together with individual I 12139 views. (To accompany H. R. 6543). Dunwoody, J. Report No. 91-566, Calendar No. LABELLING OF CIGARETTE PACKETS. 561, Dec 5, 1969, 29 pp. nrrirsorningT9British Journal of Hoe21111 Medicine

I 12173 See AleoJ 10662, C 11626 Mueller, M. ANTI-SMOKING PONES GAIN GROUND. Science 165(3693):569, Aug 8, 1969.

I 12285 Canadian Journal of Publio Health. SMOKING AND HEALTH--A MORE FORCEFUL STAND. Canadian Journal of Public Health 6o(9):333 47-771Tri9T9.

I 12291 U.S. Medicine. STRONG HEALTH WARNING IN CIGARETTE ADS URGED.U.S. Medicine 5(14118, Jul 15, 19697--

1 12738 Parsons, W. B.,-Jr. CIGARETTE SMOKING: WILL THIS KILLER AGAIN BF REPRIEVED?Medical Digest 15(10)113-6, Oct 1969.

I 12836 House of Commons of Canada, 28t:h Parliament, 2nd Seesir.n. STANDING COMMITTEE ON HEALTH, WELFARE AND SOCIAL AFFAIRS. House of Commons of Canada, 28th Parliament, 2nd Session, No. 1, Nov 18 and 20, 1969, pp. 3-60.

I 12838 U.S. Senate, 91st Congress, 1st Session. CIGARETTE ADVERTISING AND LABELING. Hearing before the Coneumer Subcommittee, of the Committee on Commerce, United States Senate, 91st Congress, 1st Session on H. R. 6543 to Extend Public Health Protection with Respect to Cigarette Smoking, and for Other Purpose..Serial No. 91-25, Jul 22, 1969, 193 pp.

277 2 SECTION J. EDUCATIONALAND RESEARCH PROGRAMS

J 10211 J 10265 Wynder, E. L. and Hoffmann, D. (Editors) Hamburg, M. V. TOWARD A LESS HARMFUL CIGARETTE. U. S. WHAT CAN THE SCHOOLS DO?Bulletin of .Department of Health, Education, and New York AcademQ, of MediciR7-41177): Welfare, Public Health Service, Bethesda, T.726755; Dec 1968. Maryland, National Cancer Institute Monograph No. 28, Jun 1968, 282 pp. J 10276 Pachman, D. J. J 10215 THE FIGHT AGAINST SMOKING IN CHILDREN. Waingrow, S. and Horn, D. Illinois Medical Journal 134(5)1625-31, RELATIONSHIP OF NUMBER OF CIGARETTES Nov T6. SMOKED TO "TAR" RATING. In: Wynder, E. L. and Hoffmann, D. (Editors). Toward A Less Harmful Cigarette. U. S. Depart- J 10282 ment of Health, Education, and Welfare, Grant, C. Y. Public Health Service, National Cancer EOSPITAL LEADERSHIP IN ANTISMOKING Institute Monograph No. 28, Jun 1968, DRIVES. Journal of the American pp. 29-33. Hospital AggantrinV(22):74-7, Nov 76, 1968. J 10240 Homburger, F., Moore, G. E., Bock, F. G., J 10285 Dalhamn, T., and Rylander, R. Canadian Medical Association Journal. CHAPTER IV. SUGGESTED MEASURES FOR LESS MEDICAL NEWS IN BRIEF. FIRST REPORT OF HARMFUL CIGARETTES. A.--RECOMMENDATIONS TAR-NICOTINE STUDY. Canadian Medical BY INDIVIDUAIS. In: Wynder, E. L. and Association Journal 9922):44,12, Dec Hoffmann, D. (Editors). Toward A 7, 1968. Less Harmful Cigarette.U. S. Depart- ment of Health, Education, and Welfare, Public Health Service, National Cancer J 10287 Institute Monograph No. 28, Jun 1968, ACS Cancer News. pp. 273-5, 277. BILL TAMAN'S LAST CASE. ACS Cancer News 22(2)112-3, Fall-Winter 19787 J 10244 Fine, S. L. J 10296 TCBACC0-STAINED AESCULAPIUS. New Bulletin Medical Society of the County of England Journal of Medicine 273M)11291, Kings and the Academy of Medicine of bec 5, OM Brooklyn, Inc. RESEARCHER LIKENS CIGARETTS TO ARSENIC. Bulletin Medical Society Ihs County J 10253 Zry_rai he AWCde Boyle, C. M. BFOOklyn, TEC% aT875R-7/68. SOME FACTORS AFFECTING THE SMOKING HABITS OF A GROUP OF TEENAGERS, Lancet 2(7581)11287-9, Dec 14, 1968. J 103C0 Rentchndck, P. ARE ANTI - SMOKING POSTERS REALLY EFFECTIVE? J 10258 UICC Bulletin 6(*2-5, SeP 1968. O'Rourke, A. and O'Sullivan, N. A DUBLIN SCHOOLS SMOKING SURVEY. PART II. SMOKING AND ATTITUDES. Irish Journal J 10320 of Medical Science 1(10)Tr6379, Oct 1968. Arno,d, G. L'HERBE EMPOISONNEE. (THE POISONOUS WEED.) Medecinl et Hygiene 26(840): J 10264 1086, Oct 2, 1968, French (Abs.) Medical Record. PULMONARY OBSTRUCTIVE DISEASE.Medical The author has commented briefly on Record 59(10):301, Dec 1968. recent articles in British journals regarding hopes for manufacturing a harmless cigarette. Mention was made of

276 J 10320 (continued) J 10344 the work at Harrogate in inducing skin AMA News. cancers by painting mouse skin with CIGARET ADS THREATENED. AMA News 11(49)1 tobacco smoke residues and their work 10, Dec 9, 1968. in the preperation of polycyclic hydrocarbons from smoke condensates.Also mentioned was the work of researchers at J 10349 Harvard in detecting Polonium in the MD. bronchial epithelium of smokers and lesser NEW WARNINGS AGAINST SMOKING. MD quantities in nonsmokers. Passey 12(9):86, Sep 1968. demonstrated that some mice rapidly succumbed to respiratory diseases when exposed to cigarette smoke while other J 10360 mice who had been administered identical Medical News. quantities of smoke remained unaffected. BUT ANGLO-SAXON DIDN'T HAVE A WORD FOR It was speculated that the manner of IT. Medical News (320):15, Nov 22, 1968. curing tobacco had some influence on the properties of the tobacco and of the smoke. The fabrication of a harmless J 10383 cigarette however appeared remote. David U. S. Department of Health, Education, Hamilton dealt with the importance of the and Welfare, Public Health Service and tobacco industry in the British Chadwick, D. R. economy. A PHYSICIAN TALKS ABOUT SMOKING. U. S. Department of Health, Education, and Welfare, Public Health Service, J 10321 Washington, D. C., Netional Clearing- Brighetti, A. house for Smoking and Health, 1968, DALLA PANACEA AL TABACCO. (UNA MEMORIA 31 pp. INEDITA DEGLI INIZI DEL SECOLO XVIII). (FROM THE PANACEA TO THE TOB,,CCO. (AN ANONYMOUS PAPER FROM THE BEGINNING OF J 10387 THE EIGHTEENTH CENTURY).) Policlinic°. Opinion Research Corporation Caravan Sezione Practice 7142 :1371-7-87-6517-a, Surveys, Inc. '4968, ItgagEVbs. ATTITUDES TOWARD CIGARETTE ADVERTISING AND WARNING LABELS ON CIGARETTE Brighetti, A., From the panacea to PACKAGES. Research findings prepared the tobacco. The Author reports on an for the American Cancer Society and inedited anonymous paper, which he found for the Federal Trade Commissior, at the Vatican Apostolic library written Opinion Research Corporation Caravan at the beginning of the XVIII century for Surveys, Inc., Princeton, N. J., princes Boncompagni Ludovisi's use. As May 1968, 25 pp. an introductory note the author gives some considerations on tobacco and its use with quotations from some well-known authors J 10388 of the past. The tobacco, which was Gilbert Youth Services, Inc. received in Europe as a true panacea, a A RESEARCH STUDY CONDUCTED AMONG remedy for a nurber of diseases, had YOUNG PEOPLE FOR AMERICAN CANCER already begun to bring abort the first SOCIETY. Report prepared for the disappointments to such a degree that American Cancer Society, Gilbert moderation was recommended in its use. Youth Services, Inc. 1959, 20 pp.

J 10340 J 10390 Rhode Island Medical Journal. Lieberman Research, Inc. TEENAGE SMOKING.Rhode Islrnd Medical THE INCIDENCE OF CIGARETTE SMOKING Journal 52(1):t0, DURING TELEVISION PROGRAMS. Report Prepared for the American Cancer Society, Lieberman Research, Inc., J 10341 New York, N. Y., Jun 1968, 21 pp. Sadler M. A PILOT PROGRAM IN HEALTH EDUCATION RELATED TO THE HAZARDS OF CIGARETTE SMOKING. Study Indicates Need for Start in Anti-smoking Education. Rhode Island Medical Journal 52(1)136-8, .7.079117---

279 J 10391 J 10427 (continued) Moore, R. J. and Wake, F. R. secondary schools 89.6 percent of the SOCIO-PSYCHOLOGICAL ASPECTS OF boys and 57.1 percent of the girls. CIGARETTE SMOKING.Report submitted The social position of the parents had under Project No. 305-8-19 for the no clear-cut influence on the age of Canadian Department of National the first contact with cigarettes. On Health and Welfare, Department of the other hand higher percentages of Psychology, Carleton University, smoking children were observed- Ottawa, Ontario, Canada, Mar 7, 1968, particularly in elementary schools- - 98 PP. in th)se children whose parents smoked. (Author Abstract)

J 10394 Zagona, S. V. and Bator, T. F. J 10459 USE OF THE SEMANTIC DIFFERENTIAL 1N Thomas, N. CROSS-EFCTIONAL STUDY OF THE SMOKING ATTITUDES OF NEW HAVEN DEVELOPMENT OF STUDENTS' ATTITUDES COUNTY PHYSICIANS: A SURVEY. TOWARD PRZSENT SELF, FUTURE SELF AND Connecticut Medicine 32(12):902-5, SrOKERS OF VARIOUS AGES. Paper Dec .CO68. presented at the 48th annual meeting of the Western Psychological Associa- tion, San Diego, Cal., Mar 28, 1968, J 10463 17 PP. U. S. Department of Health, Education, and Welfare, Public Health Service. WHAT WE KNOW ABOUT CHILDREN AND J 10405 SMOKING. U. S. Department of Health, Journal of the American Medical Education, and Welfare, Public Health Association. Service, National Clearinghouse for CIGARETTE CONSUMPTION DOWN SLIGHTLY Smoking and Health, Arlington, Va., AFTER FIVE YEARS OF SMOKING DEBAT:. Public Health Service Publication Journal of the American Medical No. 1711, Oct 1968, 5 PP. rgia-iiitT6n-07(3):475-5, -Jan 20,'1969.

J 10486 J 10407 Walker, R. E., Nicolay, R. C., Dunn, D. F. Kluczny, R., and Riedel, R. G. SMOKING--ACADEMICALLY SPEAKING! PSYCHOLOGICAL CORREL1TES OF SMOKING. Journal of the American College Journal of Clinical Psychology 25(1)t UTZTEAssoaitlon 15f162-7, Dec 1966. 42-4, An 1969.

J 10427 J 10491 Leowski, J. and Saplis-Krasowska, L. Robbins, W. T. PIERWSZY KONTAKT Z PAPIEROSAMI COLLEGE ANTI-CIGARETTE PROGRAMS. MLODZIEZY SZKOLNEJ WOJEWODZTWA Journal ef the American College WARSZAWSKIEGO. (FIRST CONTACTS Realth Assorritra71(1):179-8g, WITH CIGARETTE SMOKING IN SCHOOL Dec 17617. CHILDREN IN THE PROVINCE OF WARSAW.) Zdrowie Publiczne 79(10):823-32, Oct 1968, Fatah (Abs.) J 10497 Allen, W. A., Angermann, O., and The authors present the results Fackler, W. A. of inquiries concerning the age at DO PARENTS CARE IF THEIR CHILDERN which the first contact with cigarette SMOKE? International Journal of smoking occured in 1922 school Health Education 11(3):1-26-3,T968. children from elementary schools and secondary schools in the Province of Warsaw. In the work the correlation J 10502 between the age of beginning of U. S. Department of Health, Education, smoking and the social class of the and Welfare, Public Health Service. parents, the smoking of parents and SMOKINO AND HEALTH EXPERIMENTS the age of the child was sought. The DEMONSTRATIONS, AND EXHIBITS. U. S. numerical data obtained show that in Department of Health, Education, and most cases, school children have Welfare, Public Health Service, already tried to smoke (at least they National Clearinghouse for Smoking knew the taste of cigarettes)--in and Health, Arlington, Va., Public elementary schools 70.7 percent of the Health Service Publication No. 1843, boys and 25.6 percent of the girls, in 1968, 23 pp.

200 ag4 J 10509 J 10599 Shambaugh, G. E., Jr. Veldman, D. J. and Down, O. H. SMOKING IN CHILDREN.Archives of PERSONALITY AND PERFORMANCE Otolaryngolsgx 89(3):445-6, MarT969. CHARACTERISTICS ASSOCIATED WITH CIGARETTE SMOKING AMON3 COLLEGE FRESHMEN.Journal'of Consulting J 10530 and Clinicai Psyeheray 33(1):109-19, Holter, F. J. 1"776 i969. STUDY AND DEVELOPMENT OF SMOKING AND HEALTH PROGRAMS IN A TEACHINO TRAINING INSTITUTION. Financed under Contract J 10602 P. H. 108-66-198 by the U. S. Depart- Green, D. E. and Horn, D. ment or Health, Education, and INCIDENCE OF SMOKING BEHAVIOR IN Presented at the Welfare, Public Health Service, 1968, POPULATION SUB - GROUPS. 225 pp. Workshop on the Implications of Cigarette Smoking for U. S. Public Health Service Medical Care Facilities, Sheraton-Park J 10530 Hotel, Washington D. C., Jun 3-4, 196E, Connecticu, Healtl Bulletin. 8 PP. FEW DOCTORS STIL SMOKE.Connecticut Health Bulletin t9, Jan Mr-- J 10622 Oirond, J. J 10539 TABAC ET SANTE. (TOBACCO AND HEALTH.) Southern Medical JourncT. Semaine Medicale Professionnelle et CIGARETTE SMOKING AND EALTH. Southern Fre-dari:SUELM7174(73)1391-2, Dec rd, Medical Journal 62(2)(.'6-7, Feb 1969. 180; French The purposes of the 10 work groups J 10565 of the International Smoking and Health Flick, A. J. Congress held in New York in September HOSPITAL SALE OF ClIOETTES. Journal 1967 were listed. A series of recommen- of the American MNdicA AssociiT17017 dations by the group chairmen were then m71'0)=2.916, .,969. advanced for a determined campaign with 3 essential objectives, to keep juveniles from commencing to smoke, to convince J 10569 others not to siert and to convince American Academy of General Practice. smokers to reduce their consumption of 40 PERCENT OF FAMILY DOCTORS QUIT cigarettes or, if possible, to stop SMOKING CIOARETTES, AAOP SURVEY smoking. Typical proposed measures to SHOWS. News Release from American accomplish these purposes included Academy of Oeneral Practice, Kansas limitations on the sale of cigarettes, City, Missouri, May 29, 1968, 3 pp. publicity on the harmfulness of cigarettes and tobacco, education of professors and students, forbidding public figures J 10571 (actors, etc.) to smoke in public, and to Oreen, D. E. and Horn, D. develop a program of psycholofical and PHYSICIANS' ATTITUDES TOWARD THEIR pharmacological research in order to INVOLVEMENT IN SMOKINO PROBLEMS OF determine the reasons for smoking and PATIENTS. Presented at the National the means for breaking the habit. Forum on Office Management of Smoking Problems, Chicago, Ill., Apr 11, 1968, 6 pp. J 10644 Challenge. STATISTICS SHOW SMOKING DECREASE. J 10578 Challenge in.p., Feb 1969. WaerhaUg, J. PREVALENCE OF PERIODONTAL DISEASE IN CEYLON. Association with Age, J 10645 Sex, Oral Hygiene, Socioeconomic) Challenge. Factors, Vitamin Deficiencies, TEENS TELL TEENS NOT TO SMOKE. Challenge Malnutrition, Betel and Tobacco :7, Feb 1969. Consumption and Ethnio Orcup. Final Report. of pdcntologica Scandinav1TA-25:205-31, 1f66.

2H 4%245 J 10647 J 10673 Bulletin of the Philadelphia County Dental Horn, D. Society. THE HEALTH CONSEQUENCES OF SMOKING. DENTISTS AND SMOKING.Bulletkn of the Ins Borgatta, E. F. and Evans, R. R. Philadelphia CountDental Society (Editors). Smoking, Health, & Behavior. 34(6)519, Mar Chicago, Ill., Aldine Publishing Co., 1968, pp. 52-80.

J 10649 AMA News. CANADA MAY BAN ALL CIGARET ADS. AMA News J 10674 12(6)59, Feb 1969. Hardy, D. R. SMOKING AND HEALTH' THE IMPORTANCE OF OBJECTIVITY. Ins Borgatta; E. F. and J 10655 Evans, R. R. (Editors). Smoking, Health, Medical News. & Behavior. Chicago, Ill., Aldine Pub- CANADIANS SMOKE MOST. Medical News lishing Co., 1968, pp. 41-51. (324-325)55, Dec 20-27, 1968. J 10675 J 10658 Guilford, J. S. Levine, S. SMOKING AND HEALTH--REVISITED. Ins SUMMARY AND IMPLICATIONS FOR FUTURE Borgatta, E. F. and Evans, R. M. RESEARCH. Ins Borgatta, E. F. and (Editors). Smoking, Health, & Behavior. Evans, R. R., (Editors). Smoking, Chicago, Ill., Aldine Publishing Co., Health, & Behavior. Chicago, Ill., 1968, PP. 22-40. Aldine Publishing Co., 1968, pp. 274-81.

.1 10676 J 10659 Horn, 0. Tannenbaum, P. H. SOME FACTORS IN SMOKING AND ITS CESSATION. CIGARETTE ADVERTISING AND THE MASS Ins Borgatta, E. F. and Evans, R. R. MEDIA. Ins Borgatta, E. F. and Evans, (Editors). Smoking, Health, & Behavior. R. R., (Editors).Snaking, Health, & Chicago, Ill., Aldine Publishing Co., Behavior. Chicago, 111., Aldine 1968, PP. 12-21. Publishing Co., 1968, pp. 267-73. J 10677 J 10662 Borgatta, E. F. Moss, F. E. SOME NOTES ON THE HISTORY OF TOBACCO USE. SMOKING AND HEALTH:A LEGISLATOR'S In: Borgatta, E. F. and Evans, R. R. VIEW. Ins Borgatta, E. F. and (Editors). Smoking, Health, & Behavior. Evans, R. R. (Editors).Smoking, Chicago, Ill., Aldine Publishing Health, and Behavior. Chicago, Ill., Co., 1968, pp. 3-11. Aldine Publishing Co., 1968, pp. 251-6. J 10678 Borgatta, E. F. and Evans, R. R. (Editors). J 10666 SMOKING, HEALTH, & BEHAVIOR. Chicago, Grant, R. L. and Waltman, M. Ill., Aldine Publishing Co., 1968, 288 pp. CIGARETTE SMOKING AND SCHOOL CHILI ENS A LONGITUDINAL STUDY. In Borgatta, E. F. and Evans, R. R. (Editors). J 10681 Smoking,Health, & Behavior. Chicago, Rentchnick, P. .I11., Aldine Publishing Co., 1968, LES AFFICHES CONTRE L'USAGE DU PP. 189-205. TABAC ABOUTISSENT A UN (POSTERS AGAINST THE USE 0? TOBACCO ARE SEIF-DEFEATING.)M decine et J 10670 H lane 26(844)51242, Oct 30, 1758, Rosenblatt, D. and Allen, H. erene (Abs.) USE OF GROUP THERAPY IN SMOKING! CESSATION. In: Borgatta, E. F. and Evans, R. R. Several foreign antismoking (Editors). Smoking, Health, & Behsvl,r. posta-a were analyzed concerning Chicago, Ill., Aldine Publishing Co., their ineffectiveness of presentation. 1968, pp. 122-7. It was concluded that aggressive propaganda did not serve the intended

282 J 10681 (continued) J 10i27 .purpose and that future efforts must Pediatric News. be directed toward a study of RESPOND TO ATHLETE'S ANTI-SMOKING PLEA. motivations in smoking. The results Pediatric Hews 3(1):21,44, Jan 1969. of the investigation would permit differently oriented propagandas using less rational arguments to J 10728 which the smoker might perhaps be Journal of the Iowa Medical Society. more sensitive. THE TEEN -AGE SMOKER. JoUrnal ofIhgt IotaMedical Societx 0172707-MFF 1969.

J 10689 American Journal of N,:xsing. J 10736 EQUAL TIME FOR "DON'T SMOKE" DECREED Outierrez-Colomer, L. BY FEDERAL COURT. American Journal UNA OBRA FARMACEUTICA EN LA NUEVA of Nursing 69(2):35797776-T969. ESPANA DEL SIOLO XVI. (A PHARMACY BOOK IN NEW SPAIN IN THE SIXTEENTH CENTURY.) Anales de la Real Academia J 10703 de Farmacia 34(2):737--Mr770577----- Munchener Medizinische Wochenschrift. 3ranish (Abs.) SOZIAIMEDIZINISCHE POSTULATE ZUM RAUCHERPROBLEM. (SOCIAL MEDICAL Dr. Juan Cardenas was born in Spain, POSTULATES ON THE SMOKER PROBLEM.) became professor at the university of Munchener Medizinische Wochenschrift Mexico, and at the age of 26 wrote his 1I1M):11-5-4, an 10, 19a, German "Problems and Ma. '1ous Secrets of the (Abs.) Indies", which was printed in 1591. The book dealt with many foods which A professional conference on the were then believed to have medicinal smoking problem held at Heidelberg properties, including cocoa, maize and on Oct 14-16, 1968 resulted in this tobacco as well as cinnamon, anise, 10-point program: f9 Strict sesame, chile and pimenta. Tobacco was cigarette control; (2) labeling of consumed by the natives as a pellet kept cigarette packs with tar and nicotine between the gum and cheek, or smoked in content and statement of health clay or silver pipes or wrapped in leaves, hazards; (3) abolition of automatic parti,-.11arly maize leaves. Tobacco was cigarette vending machines; (4) laudec for its varied benefits including discontinuance of cigarette advertising; asthma and stomachache when taken inter- (5) forbid smoking in public places nally; leaves placed on abdomen reduced such as hospitals and schools; (6) simian/3i in a little bag on the head or extend protection for pregnant females in a pillow it induced sleep; placed and the unborn; (7)obligation of around an individual while sleeping; it cigarette industry to develop cigarettes kept animals away it healed pricking with less toxic smoke; (8) a 1 percent by myrtle and soothed toothache and tax on cigarettes for combatting earache; snuffed, it cleared the brain. smoking-caused disorders; (9) prominent Dr. Cardenas concluded by stating that figures such as actors, etc., requested he did not believe nature had created a to set example and abstain from smoking more blessed or medicinal plant and that in publics and (10)establishment of many individuals rightly called tobacco antismoking councils under the direction the blessed herb. of nonsmoking doctors.

J 10740 J 10709 Cancer News. U. S. Medicine. LEAVE IT TO LAURIE. A Play About AID OP DENTISTS ENLISTED IN ANTI- Cigarette Smoking and Health. %.:ancer SMOKING FLiHT. U.S. Medicine 5(4): News 22(2)115, Fall 1968. 3, Feb 15, 1969.

J 10741 J 10711 Medical News. Venable, C. S. SCOTS START SMOKINO CAMPAIGN. Medical AN ANCIENT ENEMY AND NEW CHALLENGES. Era (527):12, an 10, 1969. Health Bulletin 83(11):7 -10, Nov 1968.

7 J 10744 J 10766 (continued) Jcurxal of the American Dental Association. ness has any influence on acquiring 1968 US CIGARETTE SALES DOWN PROM the habit, the relationship between PREVIOUS YEAR. Journal of the American smoking of parents and children,, to Dental Association 78(2)T/937Feb 1969. what extent children. and adolescents are informed on the harmfulness of smoking, the attitude of teachers J 10745 towards smoking and arguments used Journal of the Maine Medical Association. in antismoking campaigns. The most NINE-POINT ACTION PROGRAM ON HEALTH important findinga include: children HAZARDS OF CIGARETTE SMOKING. Journal try to smoke very soon; the age of the Maine Medical Aesociation 60(1): limit of the first trials is shifting 7-5-,17n-Ta3. to younger age groups with the more rapid physical and mental development of youth. Health education of J 10746 children and youth as regards smoking Cleveland Physician. is inadequate and not convincing. CONSEQUENCES OP SMOKINO. Cleveland (Author Abstract) Physician 54(2):10, Feb 193D. J 10786 J 10759 Westchester Medical Bulletin. Clark, O. DOES YOUR HOSPITAL STILL SELL CIGARETTES? ANTI-SMOKING PROPAGANDA.Royal Society Westchester Medical Bulletin 37(2):21, of Health Journal 88(6):305; 1361,=:Did Feb 1969. rg68. J 10788 J 10761 Halloran, J. Dalzell -Ward, A. J. LAY EDUCATION. Pennsylvania Cancer DR. A. J. DALZELL-WARD COMMENTS. Coordinating Committee Annual Report, Societ of Health Journal 88(6):305;- Bulletin No. 22, 1968, pp. 6-13. ov- ec J 10790 J 10764 Browning,R. H. and Thcrp, D. Harnett, A. L. CIGARETTES.THE OHIO THORACIC ELEMENTARYSCHOOLANTI- SMOKINOPROJECT SOCIETY REPORTS. Ohio State Medical INVOLVING HIGH SCHOOL STUDENTS. Journal Journal 65(3):245-77-R0-1-139. of School Health 29(1):43 -5, :an 1964.

J 10792 J 10766 Bulletin of the American College of Vodrazka, R. and Bartonova, M. Physicians. VYZKUM ZDRAVOTNIHO UVEDOMENI NATIONAL INTERAOENCY COUNCIL ON MLALEZE V OTAZCE KOURENI. SMOKING AND HEALTH. Bulletin of the (INVESTIOATION OF THE HEALTH American Colle e of PRPTITagerra7T: CONSCIOUSNESS OP 'JOUTH AS REGARDS Tr7rerl . SMOKING.) Ceskoslovenske Zdravotnict4 16(6):337-42, 1968, Czech (Abs.) J 10806 Dalzell-Ward, A. J. The object of this research was THE LAST TEN YEARS IN HEALTH Out:A- to obtain an idea of smoking in youth; TION. Medical Officer 120(22)s how young people are influenced and 313-5, REV-73; TM informed on this problem and on attitudes of young people to smoking. The dats were obtained by the method J 10814 of group enquiries, based on a Michigan Medicine. questionnaire which was filled in by SMOKINOHEALTH COUNCIL TO INCLUDE the students in the presence of the DOCTORS IN ALL '69 PROJECTS. field worker. Data were obtained Michigan Medicine 68(3):159, Feb 1969. fry a total of 1599 subjects (from 1219 students, 212 parents, and 168 teachers and guardians). The J1C819 authors assessed: at what age boys AMA News. and girls try to smoke, whether sick- HAZARDS OP SNAKING. AMA News 12(5): 4, Feb 10, 1969.

284 ass J 10825 J 10920 Journal of the Indiana State Medical Goldstein, D. N. Aesociation. SLOW PROGRESS REPORT. (Editorial) DISCONTINUANCE OF CIGARETTE SMOKING. Wisconsin Medical Journal 68(2): Journal of the Indiana State Medical 122 -3, FE1577677- mm7Ertaro-r,72(1-71177=377Er,rg-o= J 10929 J 10842 Koch, A. W. Jost, F. and Schievelbein, H. "SMOKING ec HEALTH OF YOUTH". Bulletin TABAKGEWOHNUNG tJND TABAKENTWOHNUNG. of the Lancaster clIK and Count7-11a/ral (TOBACCO HABITUATION AND TOBACCO rareEry 54i7,2TVIT; PST' 1969. DETOXIFICATION.) /n: Schievelbein, H. (Editor). N1kotin: Pharmakologie and Toxikologie des Tabakrauche8. J 10948 Stuttgart (West Germany), Georg Thieme, Wartvelt, K., Christie, N., Holbaek-H Verlag, 1968, pp. 82-98., German (Abs.) Hanssen, L., Mork, T., Nilsen, E., Vormeland, O., and Aas, B. Motivation in acquiring the smoking PAVIRKNING AV ROYKEATFERD. (EFFECT OF habit was reviewed.Tobacco detoxifica- SMOKING.) Landeforeningen Mot Kreft. tion was dealt with under these Oslo, Norway, Apr 1, 1967, 245 pp, headings: preparatory detoxification Norwegian (Abs.) mtthods (basis for psychotherapy), drug datoxlfication, general and The data presented here heve been special psychotherapy, and results of selected for the express purpose of detoxification treatment. There was warning individuals, especiall; the youth, also a brief review of the psychological against beginning the smoking habit and and biological factors involved in the to furnish arguments for discontinuing or reported gain in weight following nicotine reducing the consumption of cigarettes. detoxification. The data include the economic aspects of the smoking habit, the health consequences of smoking, motivation in begin- J 10877 ning or continuing smoking, the results Greater Kansas City Medical Bulletin. of withdrawal clinics by tIle various JCMS COUNCIL VOTES TO OPPOSE: SALE OF methods commonly em:loyed, and the work TOBACCO PRODUCTS IN HOSPITALS. Greater of various organizations engaged in anti- Kansas city MedicaL-7- l Bulletin 64(mm- smoking campaigns.Tables and graphs in- ra clude the mortality due to lung cancer and myocardial infarct by sex, age group, and smoking habit.A review of the anti- J 10880 smoking efforts in Norway and other Illinois Medical Journal. countries is given in the appendix. NORTHWESTERN SURVEYS STUDENT SMOKERS. Illinois Medical Journal 155(2):195, IFTV1371.- J 10955 Chester County Medicine. IT CAN'T HAPPEN TO ME1 (Editorial) J 10893 Chester County Medicine 6(4)14-5, Apr Kilpatrick, J. J. StV77 AS OTHERS SEE IT:, FCC AND CIGARET ADS. AMA News 12t8):4, Mar 3, 1969. J 10974 Medical News. J 10904 AMERICAN SMOKING RATE STARTING TO New York Medicine. DECLINE. Medical Newe (329):20, an THE TROUBLE WITH SMOKING IS STARTING. 24, 1969. New York Medicine 25(4):161, Apr 1969.

J 10982 J 10911 Medical Journal of Australia. Oaudet, F. J. and Hug11, W. C., Jr. SMOKING AND HEALTH. Medical Journal of CONCOMITANT HABIT CHANGES ASSOCIATED Australia 1(2)184, JaE-717-11477---- WITH CHANGES IN SMOKING HABITS: A Pilot Study. Medical Times 97(4)s195-206, Apr 1969.

aft285 J 10984 J M045 (continued) Medical News. face value, questions about the amount TEACHING CHILDREN TO SMOKE.Medical of tobacco used and the manner in which News (328):4, Jan 17, 1969. ingested will be answered in misleading ways in ae many as 'O percent of the cases surveyed. Statistics discriminate J 10990 by age, amount of cigarettes consumed, Rocky Mountain Medical Journal. type (e.g., pipes, cigars) of tcbacco, THE WASHINGTON SCENE.Roc Mountain and other pertinent parameters. Medical Journal 66(3):6r,-EGEr-.C9 377

J 11060 J 10997 Tobacco. Langaton, H. T. DOCTOR DEFENDS TOBACCO AOAINST HEALTH WHY NOT THE WHOLE TRUTH? Swypa, CHAROE. Tobacco 138(18)19, 26, May 2, Gynecology & Obstetrics 1211711 1969. 1065-6, !Gel

J 11062 J 11011 Swam, N. U.S. Department of Health, Edvattion, and MANNEQUINS DEMONSTRATE KALARDS OF SMOK- Welfare, Public Health Service. ING. Indiana State Board of Health THE HEALTH CONSEQUENCES OF SMOKING. 1968 71B-7R17- SUPPLEMENT TO THE 1967 PUBLIC HEALTH SER- VICE REVIEW. U.S. Department of Health, Education, and Welfare, Public Health J 1108$ Service, Washington, D. C., Public Health Medical Officer. Service Publication No. 1696, 1168, 117 ciumgrru SMOKING. Medical Officer pp. 121(4)143, Jan 24, 17617--

J 11036 J 11096 Mattace-Raso, 0. and Ioll, A. AMA News. INDAGINE SULLIABITUDINE DEL FUMO TRA CIGARET AD BAN, PACK WARNING URGED. OLI ALUMNI DELLS SCUOLE NEDIS OtOTONESI. AMA News 12(12):9, Mar 31, 1969. (INVESTIOATION OF TNS SMOKlNG OF SECONDARY SCHOOL BOYS 1N CROTONE. Annali dellc Sanita Pubblica 29(4 t J 11100 r019:7137-211=rartg37-nfrian (Abs.) Journal of the Maine Medical Association. FORMAL RECOMMENDATIONS OF THE NATIONAL A survey carried out among tte secon- FORUM CV OFFICE MANAGEMENT OF SMOKING dary school boys of Crotone led the PROBLEMS. Jou/nal of the Maine Medical authors to ascertain that 50.90 percent Association-60T3Tri; Fee rgrr of school people of both sexes tave smoking habits and that the beginning age rae.ses between 14 and 15. Socioeconomic J 11103 conditions as well ae external and school Medical Bulletin of the Montgomery County surroundings have been recognised as Medical Society. factors capable of influencing the habits THE TROUBLE WITH SMOKING IS STARTLIG. we are referring to (Author Abstract). Medical Bulletin of the Montgomery UrirMiraialToneTY725(4)772, Apr J 11045 Yeller, O. D. PALITELIGHSTEN AV OPPLYSNINGER 04 J 11104 ROKEVANER. (RELIABILITY OP STATAKENTS Journal of the Medical Association of the ABOUT SMOKINO HABITS.)Tideskriftor State of Alabama. den Norsk* LaegeforentrucaT(217)T.M1-4-, THE TROUBLE WITH SMOKINO IS STARING. 711"771T5ITtefran(Abe. (Editorial) Journal of the Medical Association ortlii-gtne-7 KNEEN Pertinent graphs ivoompany a :statis- 3819):795, )17 rm. tical evaluation of patients' response to a questionnaire on smoking habits. The questionnaire was devised with some J 11106 loaded questions' to ascertain 'be AMA News. veracity of people answering such TONY cvnTi AIDS ACS CAMPAIGN. AMA statistical surveys. It was found that News 1(12):2, Mar 31, 1969. while statements likeI smokesnd 'I do not smoke' can generally be taken at

214 3 11107 J 11218 (continued) Medical Bulletin of the Montgomery County ALCOOLICOS) OASTRAM EM ALCOOL E TABACO Medical Society. 218 MILHOES DE CONTOS! (IN 1967, THE IS CIGARETTE SMOKING A COMMUNICABLE INHABITANTS OF FEDERAL GERMANY (WHERE DISEASE? Medical Bulletin of the MIRE ARE 600,000 ALCOHOLICS) SPENT 218 MontgomeryMTEg Medical Sociai 14711JON CONTOS ON ALCOHOL AND TOBACCO.) 25(4):71-2, Apr 1969. Jornal do Medico 67(1350):714, Dec 7, rallirlkiituguese (Abs.)

J 11111 The inhabitants of the Federal Medical News. Republic drank more and smoked lean in CIGARETTES BAN ON EIRE TV. Medical 1967. Consumption of both types of New (334):6, Feb 28, 1969. products was set at 30.3 billion mar1,4 (218 million contos) of which alcoholic beverages accounted for 20 billion marks. J 11117 ConsurrItion of cigarettes dropped 3 North Carolina Medical Journal. percent and cigars, 8 percent, Probably THE MONTH IN WASHINGTON.North Carolina due to higher taxes on tobacco products. Medical Journal 30(3):120-171ir11117- Consumption of cigarettes was 99 billion pieces. Consumption of alcoholic brev- erages increased among women and young J 11118 people. There was also observed a great- Journal of the Medical Association of the er tendency to drink at hone rather than State of Alabama. in bars and taverns, because of home THE MONTH IN WASHINGTON. Journal of the television and laws against drunken Medical Association of the-Wa e or driving. MUM 3509):864, 837,-TZ9-72, "Mar J 11235 Jceanal of the Medical Society of New J Jersey. Pollock, M. B. THE PHYSICIAN AS AN ENCOURAGER OF AN EVALUATION INSTRUMENT TO APPRAISE CIGARETTE SMOKING.Journal of the KNOWLEDGE AND BEHAVIOR REGARDING USE OF Medical Society of NEWpnerBETY)1 STIMULANTS AND DEPRESSANTS. 'march 11,Prgy INgrterly of the American Assoc al.ion For Health, sine'i-Mication, And RecrWiran. 9 0717-58E-19117 J 11237 Cook, P. J., Doll, R., and Fella m, S. A. J 11131 A MATHEMATICAL MODEL FOR THE AGE Journal of the American Medical Association. DISTRIBUTION OF CANCER IN MAN. YEARS AGO: *BOY BANE" - OR THE CIGARETTE. International Journal of Cancer Journal of the American Medical Associa- 410393-112, JR-M-1M. tion 20813)77g97-MiY77 11117-- J 11238 J 11138 Dickson, S. Norman-Taylor, W. CLASS ATTITUDES TO SMOKING. TOBACCO AND HEALTH EDUCATION.Royal Medical Officer 121(8)396-8, Institute of Public Health & Hyejene P77717 171137 oul"7=311T-1711-447-3'277517Dec19613. J 11275 J 11159 Jornal do Medico. Journal of the American Dental MIMES DE FUMADORES ENOLESES QUEREM Association. DEIXAR DE,FUMAR (MAS NAO POR CAUSA DO OPPOSITION TO CIGARETTE SMOKING CANCRO...) (MILLIONS OF ENGLISH INCREASES IN U.S. Journal of the SMOKERS WANT TO STOP SMOKING (BUT NOT American Dental Association BECAUSE OF CANCER---).) .Jornal do 780)3724:37-Ur Inv. Medico 68(1359)3403, Feb 377707- P3FErbeee (Abs.)

J 11218 Half of Great Britian's 23 million Jornal do Medico. smokers would like to give up the habit EM 1967, OS HABTTANTES DA ALEMANHA according to a survey by the Ministry of FEDERAL (ONDE EXISTEM 600 MIL Health.The coat of the tobaccO products, rather than the fear of lung cancer,

1B7 291 J 11275 (continued) .7 11508 bronchitis, or throat irritation, is the AMA News. principal reason for wanting to stop. SCARING SMOKERS IS ASH TRAY'S GOAL. Pipe, cigar, and cigarillo smokers can AMA News 12(14):11, Apr 14, 1969. stop smoking more easily than smokers of cigarettes. J 11310 Pennsylvania's Health. J 11277 CONTEMPORATiy COMMENT. Pennsylvania's Leowski, J. and Saplis-Krasowska, L. Health 30(1):9, Sprir% 1969. CZESTOSC PALMA PAPIBEOSOI PRZEZ MIODZIEZ SZKOLNA WOJEWODZTWA WAHSZAWSKIEGO. (INCIDENCE OF CIGARETTE J 11317 SMOKING AMONG THE SCHOOL CHILDREN IN THE Diehl, H. S. PROVINCE OF WARSAW.)Zdrowie Publiczne SMOKING AND HEALTH EDUCATION. 80(2):89-98, Feb 1969,-rarFff 7B171 Pennsylvania's Health 30(1):6, Spring 1969. On the basis of inquiry investigations carried out in 1966 on 1992 school children in the schools cf the Province of J 1131? Warsaw the authors analyze the incidence U.S. epartment of Health, EducatiL,,,, and of cigarette smoking among the school Welfpre, Public Health Service. children of primary and secondary schools S'40%Sti'S SELF-TESTING KIT. Part lt dth regard to the age and sex cf the The Tests. U.S. Department of Health, children and selected environmental Education, and Welfare, Public Health factors. It was found that 42.4 percent Service, Washington, D.C., Public of the boys in the elementary schools Health Service Publication No 1904, smoke cigarettes (27 percent smoke Part I, 1969,'5 Tn. occasionally and 15.2 percent smoke every day) 11.2 percent of the girls smoke aleo (10.0 percent occLeionally and 1.2 percent J 11320 every day). In secondary schools 64.4 U.S. Department of Health, Education, and Percent of the boys (40.4 percent occa- Welfare, Public Health Service. sionally and 24.0 percent every day) and SMOKER'S SELF-TESTING KIT. Part 2. 34.4 percent of the girls (29.9 percent Interpretation of the Test Scores. occasionally and 4.: every day) smoke U.S. Department of Health, Education, cigarettes. The percentage or smokers and Welfare, Washington, D.C., Public and the frequency of smoking increase in Health Service Publication No. 1904, successive age groups. It was observed Part 2, 1969, 6 pp. that smoking is more frequent in children whose parents smoke too.A correlation was also found between the frequency of J 11321 alcohol drinking and the kind of alcohol National Interagency Council on Smoking drunk by the youths and the development and Health. of the smoking habit and the frequency WORLD CONFERENCE ON SMOKING AND of smoking. No correlation was observed HEALTH: A SUMMARY OF THE PROCEEDINGS. bctwsen the age of the first contact with Sponsored by the National Interagency the cigarette and the frequency of Council on Smoking and Health, New smoking. (Author Abstract). York, N.Y., Sep 11-13, 1967, 310 pp.

J 11292 J 11323 Porter, F. T. H. Moore, 0, E. ASSESSINO PUBLIC REACTION TO AN ANTI- THE RELATIONSHIP OF CIOARETTE SMOKING CAMIPAION. Ontario Medical SMOKING TO VARIOUS TYPES OF CANCER. Review 48(5):217-217-'257)%777617. Speech delivered at the World Conference on Smoking and Health, Sponsored by the National Interagency J 11296 Council on Smoking and Health, New Journal of the American Pharmaceutical York, N.Y., Sep 11-13, 1967, pp. 74-8. Association. NEW JERSEY ANTI-SMOKING CAMPAION. Journal of the American Pharmaceutical J 11324 iTanitnit-Tr477T337-nr 1969. Hill, A. B. SPEECH AT THE OPENING SESSION OF THE WORLD CONFERENCE ON SMOKING AND HEALTH. Speech delivered at the World Conference on Smoking and Health,

286 J 11330 (continued) J 11324 (continued) Interagency Council on Smoking and Sponsored by the National Interagency Health, New York, N.Y., Sep 11-13, Council on Smoking and Health, New 1967, pp. 161-69. York, N.Y., Sep 11-13. 1967, pp. 92-6.

J 11331 J 11325 Robbins, W. T. Godber, G. E. CURRENT SMOKING AND HEALTH ACTIVITIES THE BRITISH AND NORWEGIAN EXPERIENCES. IN COLLEGES AND UNIVERSITIES AND Speech delivered at the World POSSIBILITIES FOR FUTURE ACTION. Conference on Smoking and Health, Speech delivered at the World Sponsored by the National Interagency Conference on Smoking and Health, Colincil on Smoking and Health, New Sponsored by the National Interagency York, N.Y., Sep 11-13, 1967, pp. 97- Council on Smoking and Health, New 108. York, N.Y., Sep 11-13, 1967, pp. 171-87. J 11326 Evang, K. J 11332 STEPS TAKEN TO INFLUENCE SMOKING Jacobsen, G. S. HABITS IN NORWAY. Speech delivered A NORWEGIAN EXPERIENCE. Speech at the World Conference on Smoking delivered at the World Conference on and Health, Zponsored by the Smoking and Health, Sponsored by National Interagency Council on the National Interagency Council on Smoking and Health, New York, N.Y., Smoking and Health, New York, N.Y., Sep 11-13, 1967, pp. 108-17. Sep 11-13, 1967, pp. 240-2.

J 11327 J 11335 Stewart, W. H. Journal of the Medical Association of the INFLUENCING SMOKING BEHAVIOR.Speech State of Alabama. delivered at the World Conference on CIGARET ADS ON TELEVISION ARE ENCOURAGING Smoking and Health, Sponsored by the SMOKING. (Editorial comment) National Interagency Council on Journal of the Medical Association of Smoking and Health, New York, N.Y., the State ornMEE-38(10)1882, 885; Sep 11-13, 1967, pp. 118-25. Itg:

J 11328 J 11336 Horn, D. Fredrickson, D. T. THE SOCIAL, CULTURAL, AND ECONOMIC QUESTIONS PEOPLE ASK ABOUT SMOKING. FACTORS INVOLVED IN THE OROWTH OF THE National Tuberculosis and Respiratory SMCKINO HABIT. Speech delivered at Masa Association BuTritin 55(4): the World Conference on Smoking and 10-1, Apr 1969. Health, Sponsored by the National Interagency Council on Smoking and Health, New York, N.Y., Sep 11-13, J 11342 1967, pp. 126 -33. Oelband, S. F.C.C. -- OUR NEW ALLY. (Editorial) Bulletin of the Suffolk Academy 91: J 11329 Medicine 47(17113771571969. Gordon, I. THE PROBLEMS AND TECHNIQUES OP TEACHING CHILDREN NOT TO SMOKE. Speech delivered J 11343 at the World Conference on Smoking Waring, G. and Health, Sponsored by the National REPORT FROM OTTAWA. Canadian Medical Interagency Council on Smoking and Association Journal 100(12)15677-- Health, Vex York, N.Y., Sep 11-13, Mar 22, 29, mr-- 1967, pp. 144-61.

J 11344 J 11330 Canadian Family Phyeician. Hock, L. E. CIGARETTE SMOKING ON DOWNWARQ TREND. THE DIFFICULTIES INVOLVED IN TEACHING Canadian Family Physician 15(3):63, ANTI-SMOKING BEHAVIOR THROUGH FORMAL r&-71-934. SCHOOL EDUCATION. Speech delivered at the World Conference on Smoking and Health, Sponsored by the National

289 9:5 J 11380 J 11487 Gray, N. Lathrop, J. C. SMOKING AND HEALTH.Medical Journal of IN THE EDITOR'S MAILBOX. (Letter Australia 1(8):427, Feb 22, 1Tgl= Rhode Island Medical Journal52(4: TOTAW-1739. J 11384 Donald, M. N. J 11487 CONCOMITANTS OF SMOKING AMONG HIGH Sadler, M. SCHOOL STUDENTS. Medical Services IN THE EDITOR'S MAILBOX. (Reply) Journal, Canada 23(11):1416-35, Dec 1967. Rhode Island Medical Journal 52(4): 192, 194, Apr f969. J 11410 National Center for Health Statistics. J 11504 CURRENT ESTIMATES.From the Health Journal of the Medical Society of New Interview Survey, United States-1967. Jersey. U.S. Department of Health, Education, SMOKING TRUTHS FOR TEENAGERS. and Welfare, Public Health Service, Journal of the Medical S cietof Health Services and Mental Health W77iFsey Trt5)1206, Administration, Washington, D.C., Vital and Health Statistics Report, Public Health Service Publication No. 1000, J 11520 Series 10(52):1-73, May 1969. Medical Officer. YOUNG SMOKERS IN GLASGOW. Medical Officer 121(12):150, Mar 217-1M7 J 11418 Lyon, J. L. TOTAL SATISFACTION WITH SMOKING COUPONS. J 11521 New En land Journal of Medicine 280(23): Boyle, C. M. T354- ,Jun 5, 1914. SOME FACTORS RELEVANT TO FORMULATING ANTI-SMOKING PROPAGANDA FOR TEENAGERS. Medical Officer 121(12):156-8, Mar 21, J 11419 FoleyW. J., McGinn, M. E., Amoe, H. E., Jr., Coon, W. W. and Culver, D. H. CIGARETTE SMOKING AMONG MEDICAL STUDENTS. J 11522 New En land Journal of Medicine 280(23): Medical Officer. , un 5, 1969. ANTI - CIGARETTE PROPAGANDA:USA LESSONS. Medical officer 121(12): 150, Mar 2T, 1969. J 11421 Bell, J. A. E. and Laing, D. H. J 11551 STATISTICAL ANALYSIS OF MORTALITY Hudson, R. P. RATES OF CIGARETTE, PIPE AND CIGAR SMOKE GETS IN YOUR EYES. (Gueat SMOKERS.Canadian Medical Association Editorial) Greater Kansas City Journal 100(17):866-175;7437=7-- Medical BullaliTRITZOIMITMAy 15, 1969. J 11435 Medico-Legal Journal. J 11557 CONTROL OF DRUGS AND DEPENDENCE. California's Health. Medico-Legal Journal 37(Part 1):7-22, SAN DIEGO EMPLOYERS FIDGETING: THEIR SMOKERS GET SICK OFTENER. California's Health :9, May 1969. J 11444 Diehl, H. S. 11562 OPPORTUNITY UNLIMITED. (Address) South African !Wiest' Journal. Minnesota Medicine 52(4)1699-701, ALCOHOL AND TOBACCO. (Editorial) Apr 1969. South African Medical Journal4d19): SW-307173rTo;"rnir J 11448. Mallows, H. R. J 11565 SMOYIKJ HABITS ON THE FAR EAST STATION California's Health. IN 1967.Journal of the Royal Naval SHOW THEM HOW THEIR HEALTH NEEDS ARE Medical SeFfra-55TT)T7I-83", gr5arTir BETTER MET BY NOT SMOKING.Californians 1,369. Health :12, Apr 1969.

290 a.94 I J 11568 J 11622 U.S. Department of Health, Education, Evans, S. M., Wilkes, E., and and Welfare, Public Health Service, Dalrymple-Smith, D. National Clearinghouse for Smoking PRESYMPTOMATIC DIAGNOSIS. Journal of and Health. the Royal College of OensrarTMTIfron- THE FACTS ABOUT SMOKING AND HEALTH. era17N.):237-16.,1Cprt-rerrr U.S. Department of Health, Education, and Welfare, ?ublic Health Service, Health Services and Mental Health J 11636 Administration Arlington, Va. OP National Clearinghouse for Smoking TOBACCO AND THE PHS. (Editorial).OP and Health, Public Health Service 39(6):75, Jun 1969. Publication No. 1717, Oot 1968, 7 pp.

J 11637 J 11577 U.S. Medicine loll, A., Farina, W., and Sindoni, L. HORN TELLS PHYSICIANS TO DISCOURAGE L'ABITUDINE AL FUMO TRA OLI STUDENTI SMOKING.U.S. Medicine 6(10):21, DELLS SCUOLE MEDIE MESSINESI. (SMOKING May 15, 1969'7- HABITS AMONG STUDENTS OF SECONDARY SCHOOLS IN MESSINA.) Annali della Sanita Pubblica 29(5):1371:=86rAT-Oct J 11641 TRW-Italian (Abs.) Medical Journal of Australia. HEALTH AND RELATED PROBLEMSASSOCIATED Ina survey carried out among the WITH SMOKING. Medical Journal of stv.lents of secondary schools in Australia 1(14)12,71Tr777469 Wssina, the authors have ascertained that 47.74 percent of them are regular smokers.Data obtained in this survey J 11643 were discussed, taking particularly into Medical News. account those environmental factors, with- 'ANTI-SMOKING WARNINGS DO NOT AFFECT in both the family and the school, that CHILDREN'Medical News (344):9, May 9, may influence young people to contract 1969. the habit of smoking. (Author Abstract)

J 11644 J 11579 Bucks County Medicine. Youth Advioory Council Smoking & Health REPORTS CU YOUTHS SHOW: SMOKE GETS IN Committee and Michigan Youth Commission. THEIR EYES BUT LESS FREQUENTLY TODAY. PRE-TEEN SMOKING SURVEY. (Preliminary BucksCounty Medicine 60(6):4, Jun Report) Michigan Youth Commission, Arn Mir Arbor, Mich., Apr 28, 1969, 23 pp.

11647 J 11599 Journal of the American Dental Association. British Medical Journal. ADA CALLS SMOKING SERIOUS HEALTH TOBACCO-SMOKINO.Britiah Medical MENACE... Journal of the American Dental Journal 2(5650):1777-77-17777417. Assooiation-nrraf.p.,77ZilT677--

J 11609 J 11649 Hoffetaedt, E. O. W. AMA News. ANTI-MORINO. (Letter) Medical Ne CIOARET ADS HALTED.AMA News 12(20): (341)110, Apr 18, 1969. 12, May 26, 1969.

J 11621 J 11650 Royal Society of Health Journal. AMA News. U.S.A. CIGARETTE SALES DROP.Royal CMA PRAISES CIOARET AD BAH.AMA News Societ of Health Journal 89(271--- 12(21)112, Jun 2, 1969. , 1.7071767.

J 11655 Journal of the American Medical Association. OFFICE VISIT LEADS SMOKERS TO QUIT. Journal of the American Medical n771"trOn-70413,t366, 1=7 1969.

291 a95 J 11664 J 11734 Schwartz, J. L. Terris, M. A CRITICAL REVIEW AND EVALUATION OF UNA POLITICA SOCIAL DE SALUD. (A SOCIAL SMOKING CONTROL METHODS. Public Health POLITIC OF HEALTH.) Antioquia Medicos Reports 84(6):483-506,jurirgrr 18(5):161-75, 1968, Spanish (AbT7T--- The development of a 'social policy of J 11670 health is diecussed in terms of some :4' AMA News. the contemporary health rialcs encountered AIR FORCE BANS SMOKING BY PATIENTS. in today's society, such as smoking, AMA News 12(24)13, Jun 2Z1969. alcohol, heart disease, as well as in terms of various aspects.of health care, including Medicare, high medical costs, J 11680 and preventive medicine. In regards to U. S. Department of Health, Education, smoking, public health workers have and Welfare, Public Health Service, acted on the basis of the theoretical National Clearinghouse for Smoking and formulation that new problems of public Health. health could be resolved in terms of BIBLIOGRAPHY ON SMOKING AND HEALTH. changing individual behavior.The reason 1969 CUMULATION.U.S. Department of for the failure of this approach is that Health, Education, and Welfare, individual behavior with respect to Public Health Service, Washington, D. C., health, is conditioned by past history and National Clearinghouse for Smoking and by the total economic, social and politi- Health, Public Health Service Publication cal structure of society. It is essential No. 1124, Public Health Service Biblio- to formulate and implement a social policy graphy Series No. 45, May 1969, 321 pp. that fully recognizes the gravity of the health risks of smoking.A few elem;onts of such a policy that deserve J 11681 consideration are: (1) thq prohibition of Grimaldi, K. E. and Lichtenstein, E. cigarette advertising) (2) the provision HOT, SMOKY AIR AS AN AVERSIVE STIMULUS of subsidies and other aid to tobacco IN THE TREATMENT OF SMOKING. University farmers to help them change their crops of Oregon, Eugene, Ors., n. d., 16 pp. to others and to tobacco companies to assist them in changing their operations to tbe production of non-lethal articles) J 11687 and (3) a strong increase in the taxes on U.S. Federal Trade Commission. cigarettes. PROPOSED RULEMAKING PROCEEDING FOR REQUIRINGHEALTHWARNING IN CIGARETTE ADVERTISING. U.S. Federal Trade J 11737 Commission, Wsehington, D.C., Jul 1, Sawicki, F. 1969, 168 pp. PRUWLEKLENIESWOISTE CHOROBY UKLADU ODDECHOWE00 WSROD MIESZKANCOW KRAKOWA. y.Ocena Wiarygodnosci Wywiadow. J 11688 (CHRONIC NONSPECIFIC RESPIRATORY DISEASES U.S. Federal Trade Commission. IN THE CITY OF CRACOW.V. The PROPOSED RULEMAKING PROCEEDING FOR Reliability of Interviews.) Przelad REQUIRING HEALTH WARNING IN CIGARETTE Epidemiologiczny 23(1)1109 -207=77 ADVERTISING. U.S. Federal Trade Polish (Abs.) Commission, Washington, D. C., Jul 2, 1969, pp. 169-355. In a pilot study, twofold interviews were obtained from 48 persons with the in of assessing consistency between J 11690 the replies obtained at different times. Diehl, H. S. Completely consistent answers were ob- TOBACCO AND YOUR HEALTH: THE SMOKING tained from 33 percent of the persons CONTROVERSY. New York, N. Y., examined and from all the persons con- McGraw-Hill Book Company, 1969,271pp. cerning age, occupation and smoking habits. Incccsisten. replies were received on two occasions to questions con- J 11692 cerning cough expectoration, breathless- Social Research, Incorporated. nese and past illnesses. An influence CIGARETTES THEIR ROLE AND FUNCTION. of age, sex or occupation on agreement For the Chicago Tribune, Social between replies in both examinations, was Research, Incorporated, Apr SO, 1952, not found. The discrepancy of the data 33 pp. concerning onset of symptoms indicate

292 29 J 11737 (continued) J 11761 that the respondent did not attach Beffinger, J. importance to symptoms such as cough, ESPANA Y EL PROBLEMA DEL FUMAR Y phlegm production and breathlessness. LA SALUD. (SPAIN AND THE PROBLEM An influence of individual discrepancies OF SMOKING AND HEALTH,) investigacIones on mean frequencies of symptoms in the del humo delo tabaco (Tobacco smoking whole group was not demonstrated. (Author research, canaries, Espana, 1965, 3 pp, Abstract) Spanish Abs.)

Recent investigations concerning J 11753 the problem. of smoking and health Sirtori, C. conducted ovm the past ten years in IL FUMO. (SMOKING.) Gazzetta Kenya, East Africa, have shown that Sanitaria 39(7-6):364-5, 19n, the rate of lung cancer in Poland, Ttalian (Abs.) Russia, South ".frica and Spain is much lower than in the United States Some general comments are made on and England. This difference is recent scientific advances in the area attributed to the use of enzymatic of lung cancer, and bronchitis. It is fermentation in the processing of the reported that science has accomplished tobacco leaves during which the carbon much in smoking and health, even though compounds with carcinogenic activity are it has not yet effected a satiafactorY decomposed and eliminated, producing solution: cigarette consumption in the up to a 16 percent weight loss in the United States has not risen in the last leaf by the end of the process. Ciga- 4 years. The increase of lung cancer in rettes processed in this manner produce England was less rapid in 1967 than in an alkaline smoke. In the United the preceding year.Some of the cancer- States and in other countries with ogenic substances in smoke that have been high lung cancer rates, cigarette tobac- identified are benzopyrene, chrysene, nico is pasteurized by a process called trosamine, and polonium. The importance redrying.This procedure consists of of early lung cancer diagnosis is empha- the application of high temperatures sized. Diagnostic methods such as above the level of pasteurization thoracic echermography have saved many (62 degrees C) which destroys the lives. With regard to treatment, enzymes that cause fermentation and antimitotics have proven helpful. A single thus eliminates any enzymatic fermen- 50 mg/kg dose of Endoxan is sometimes tation in the tobacco leaves. Because recommended, and a suggestion is made that of this, the leaves lose only 2 per- Kaplan's technique be used for lymphoma. cent of their weight and produce an Dextran has also been demonstrated to be acidic :smoke. There remain intact effective. A hereditary basis for lung those carbon compounds which are known cancer exists: lung cancer occurs four carcinogenic agents. times more frequently in a person with a family history of cancer and, if this individual smokes, the likelihood of J 11764 developing the disease rises to 14 times Schar, M. more frequently. It is advised that OESUNDHEITSERZIEHUNG ALS PRAVENTION. those who insist on smoking should smoke Wie Wtrkt Belehrung uber Risikofak- only the first half of the cigarette. toren? (HEALTH EDUCATION AS A PRE- VENTIVE MEASURE. What is the Effect of Instruction about Risk Factors?) J 11755 Munchener Medizinische Wochenschrift Minerva Mediae. 111125T:14, 1969, -.German VISIONS PANORAMICA SUI VARI ASPETTI (Aba.) DELLA LOTTA OONTRO I TUMORI, NEL XX ANNUALS DELLA O.M.S. (PANORAMIC Health education has achieved VIEW OP THE VARIOUS ASPECTS OF THE increased importance in preventive FIGHT AGAINST CANCER IN THE TWENTIETH medicine since at the present time ANNUM. OF THE W.H.O.) Minerva Medica the chronic diseasce which determine 59(79) :4230-2, Oct 3, 1768 7TESTMT-TAbs.) the pathological processes are to a large extent due to the living habits Purposes and problems of the World and recreation habits and not due to Health Organization were outlined. physical environmental factor'. By These included control of air pollution the example of ischemic cardiac dis- and persuasive antismoking education in eases, which since the end of the juveniles.Several works on cancer war have :shown the highest absolute prophylaxis were listed. increase, the author shows the effect

293 0291 J 11764 (continued) J 11841 (continued) of health education. Of the 4 filters. Two other sections of the criteria which are considered risk report dealt with control of air factors for ischemic cardiac dis- pollution and nuclear radiation. eases (hyperchclesterolemia, hypertension, smoking and overweight), it was possible to affect overweight J 11846 and hypertension by education and Lange, H.-J. requests for medical treatment amongst STATISTISCHE ANSATZE ZUR ERFOLOS- the employees of a machinery factory BEURTEILUNG VON KUREN IM RAHMEN DER in northeastern Switzerland.A6 far SOZIALVERSICHFRUNG. (STATISTICAL as a change of the smoking habits is ARRANGEMENT FOR THE EVALUATION OF THE concerned it was not possible to RESULTS OP TREATMENT WITHIN THE FRAME- achieve significant success with WORK OF SOCIAL SECURITY.)Medizinische educational measures. For this pur- Klinik 63(49):1977-9, Dec 6, 1968, pose marAve propaganda programmes OTE (Abe.) must be started. (Authcr Abstract) Treatments are carried out not only for the improvement or healing of J 11802 chronic diseases or as rehabilitation Backhouse, C. I. and James, I. P. measures, but also for prevention of THE RELATIONSHIP AND PREVALENCE OF disease in healthy individuals or to SMOKING, DRINKING AND DRUG TAKING IN reduce the rieka of disease in indiv- (DELINQUENT) ADOLESCENT BOYS.British iduals with so-called risk factors. Journal of Addiction 64(1):75-97-nr- The difficulties in the evaluation of r96r the success of treatment, especially in the selection of valid comparison groups and the application of reliable J 11806 success criteria were indicated. The Medical Officer. necessity for an analysis of the health BEHAVIOUR AND ANTI -SMOING STRATEGY. factors was discussed.The program Medical Officer 121(21)1291-3, May must extend for many years and requires 3, 1969. long and careful planning.The first atep is a brief preliminary investigation of the nature of the model in J 11841 which the procedures must be tested. Annali della Sanita Pubblica. SDOPPIAMENTO DELLA DIREZIONE GENERALE DELL'IGIENE PUBBLICA E DEGLI OSPEDALI. J 11886 (SEPARATION OF THE GENERAL MANAGEMENTS Little, C. C. OF PUBLIC HEALTH AND OF HOSPITALS.) REPORT OF THE SCIENTIFIC DIRECTORt Annali della Sanita Pubblica 29(3)1 1966-67.New York, N. Y., The Council nr7SVIUT4tRinTe77n5a1Th (Abs.) for Tobacco Research--U.S.A., 1968, 80 pp. The organization and responsibilities of the two sections were 1,ted. The public hygiene section wet; divided J 11895 into 7 divisions and the hospitals Medical Journal of Australia. section into 13 divisions. The CIGARETTE SMOKING.Medical Journal of report then continued with broad Australia 1(22, Supp177787 ft-9-77 sectors of interest including present or prospective action corcerning smoking and health such assRecent documentation on the effects of J 11935 smoking and methods for breaking the Vercellotti, E. and Vanini, smoking habit; legislation concerning INCHIESTA SULL'ABITUDINE AL FUMO rui I the labeling of cigarettes and the OIPENDENTI DI UNA INDUSTRIA DI TORINO. proh!bition of smoking in public (ON THE SMOKING HABITS OF THE WORKERS places; antismoking education in IN A TURIN FACTORY.) IZtene Moderns schools and the cooperation of TV 61(9-10):724-66, 1968, Itallsn TKU7) actors and public figures to set an example by not smoking in public; The authors report the results of a establishment of antismoking clinics research co smoking, which has been car- and the Distribution of antismoking ried out among the workers of a ropiness material; and the developme-A of industrial concern. In the Medical Ser- tobacco with less tar and nicotine vices of this Company are kept the cards and the develoAent of truly effective reporting periodical check-upsi the

294 J 12126 J 11935 (continued) Vercellotti, E. and Fasulo, V. data concerning 1938 male workers have ULTERIOR' OSSERVAZIONI SULL'ABITUDINE been elaborated and analyzed.This pro- AL FUMO ED ALL'ALCOOL TRA I DIPENDENTI pitious circumstance enabled the authors DI UN'INDUSTRIA METALMECCANICA. to carry out a research on a homogeneous (FUTHER OBSERVATIONS ON THE SMOKING AND sample of SS most of whom are periodical- ALCOHOL HABITS AMONO WORKERS OF A ly checked up, from the sanitary point of TURINESE METAL-INDUSTRY CONCERN.) view, for an unbroken period of ten I lane Moderns. 61(11-12)11046-75, 1968 years. The results which have been a allWT obtained seem to be, therefore, particularly representative, being bound to a The authors, following the researches rather exceptional condition.Ae far as on the habits of mucking and alcohol, the habit of smoking is concerned, it Which they carried out among the workers resulted that of the 1938 workers: of a Turinese industrial concern, report 33.17 percent do not smoke; 8.25 per- the findings of a further research on cent smoke 1-5 cigarettes daily; 16.15 the summed-up effects of tabagism and Percent smoke 6-10 cigarettes daily] alcoholism on the same subject.The moat 35.21 percent smoke 11-20 olgarettes numerous group (735 cases) was the one daily; 5.67 percent smoke more than 21 formed by workers drinking up to 1 liter cigarettes. Concerning the region from of wine daily and smoking more than 10 which the workers come, no difference cigarettes daily.Nonsmoking and was found. The research confirmed the abstemious subjects enjoy higher fact which was already revealed by most probabilities of having normal blood inquiries that young men under 20 smoke pressure. The subjects who do not smoke less than the older, above all between and drink moderately (up to 1 liter of 41-50. The values of highest arterial wine daily) enjoy better health. The pressure between 141 and 200 resulted in index is given by low absenteeism. higher percentage in the smoker group, Abstemious subjects smoking up to 10 in proportional ratio with the number cigarettes daily are likely to maintain of cigarettes one smokes. On the their weight 'nchanged. (Author Ab- contrary, among nonsmokers a shift was stract) found towards the highest values of minimum arterial pressure. Absenteeism was higher in the heavy smokers group. J 12127 As far ae the behavior of body weight is Vercellotti, E. and Fasulo, V. concerned, all data confirm higher INCHIESTA SULL'ABITUDINE AL PUMO TRA I trend to weight inarease in nonsmokers. DIPENDENTI DI UN1INDUSTRIA DI TCRINO. (Author Abstract) Nota II --Osservazioni Sugli ex fumatori. (RESEARCH ON THE SMOKING HABIT AMONO WORKERS OF AN INDUSTRY IN TURIN. J 11993 II. Observations on ex-smokers.) gene Crowdy, J. P. and Gould, A. H. Moderns61(11 - 12)11040 -5,1968, IarrICT- BRITISH SOLDIERS' SMOKING HABITS. rrsi7 A Five Year Follow-up Study. Journal of the amitm Medical searinnrcs): The authors, to complete a preceding 177:13, research on the habit of smoking, whit?: they carried out among the workers of an industry in Turin, have developed J 11994 a more complete study on a group of Burgess, A. M., Jr. and Tierney, J. T. former smokers. They found that 5.36 RHODE ISLAND PHYSICIANS' SMOKING HABIT percent of the workers (104 of 1938) REVISITED 1963-1960.Rhode Island belonged to such group. Almost every- Medical Journal 52(8)107407711171969. one benefited from having given up soakings everyone claimed to have gained weight. Only 5 subjects suffered from J 12004 some disorders as a consequence of giving Hero, M. S. (Project Coordinator) up smoking. (Author Abstract) AMERICAN COLLEGE HEALTH ASSOCIATION. FINAL REPORT-- PHASE II SMOKING AND HEALTH PROJECT. Supported by Contract J 12141 No. PH 106-66-132, Feb 28, 1969, 93 pp. University of Arizona, Center for Research on Smoking and Health. PSYCHO-SOCIAL CORRELATES OF SMOKING J 12118 BEHAVIOR AND ATTITUDES. A Final Report Rhode Island Medical Journal. Prepared for the National Clearinghouse TEEN-AUKS OP NATION SMOKING LESS, for Smelting and Health by the Center Rhode Island Medical Journal 52(7)1

295 a99 J 12141 (continued) J 12215 (continued) for Research on Smoking and Health, reported. Oscillogrsms of the peripher- University of Arizona, Tucson, Arizona. al arteries of 100 smoker patients, 76 Jul 31, 1969, 522 pp. men and 24 women of different ages and with different smoking habits paying particular attention to the pulse J 12151 frequency and the so-called pulse volume, Brunswick, A. F. were recorded before, during and after HEALTH NEEDS OF ADOLESCMTSIHOW THE smoking one cigarette. The older ADOLESCENT SEES THEM. American Journal patients exhibited manifestations of Pablic Health and the chiefly of arteriosclerosis (after 0191777S0707-rernm myocardial infarct, apoplexy, claudicatio intermittens), and metabolic disturbances (diabetes, obesity) while J 12159 the younger patients suffered mainly Washington's Health. from vegetative dystonia.The observa- SMOKING...AND THE PUBLIC SCHOOL STUDENT. tions indicated that smoking had a harm- Washington's Health 12(1)0-8, Summer ful effect on circulatory disturbances. 1969. The necessity for countering the pro- smoking propaganda of the tobacco industry was also briefly discussed. J 12176 Fletcher, C. and Doll, R. A SURVEY OP DOCTORS' ATTITUDES TO J 12217 SMOKING.British Journal of Preventive Werner, T., Woeber, Kh. and Sim, H. C. & Social MWTZTIMF3t31:145:75,u3-175- RAUCHEMCWOHNUNG EINE WICHTIOE UND TVST7--- VORDRINOLICHE AUPOABE DES ARZTES. (SMOKING DEMBITUATION. AN IMPORTANT AND URGENT PROBLEM OF THE DOCTOR.) J 12197 Medizinische Klinik 64(30):1343-51, Svenek Farmaceutisk Tidskrift. JuI 25, 19691-Wan (Abs.) TO I KULTURHISTORISK BELYSNING. (TOBACCO FROM A CULTURAL-HISTORICAL Smoking dehabituation by doctors VIEWPOINT.) Svensk Farmaceutisk should be earnestly pursued in the 1 Tidskrift 73(S.7Tirr,2, mar 10, 1969, Federal Republic. In the event the Swedish (Abs.) doctors are themselves smokers, their advisory powers are diminished. The Books which have been published hypothesis for tobacco abstinence since 1559 have both extolled and depends onaserious determination no condemned tobacco.Both kinds of longer to smoke, which cannot be sub- books had an effact upe:, the popu- stituted by the most costly of drugs. lation whose curiosity became aroused This explains the modest results of an with the result that Swedes in 1967 exclusively-drug therapy. More consumed almost 9 billion cigarettes, promising are psychotherapeutic methods. 531 million cigars of all sizes, 1750 The five-day plan, which was reported metric tone of pipe tobacco, 2390 here on the basis of 1253 observations metric tons of snuff, and 16 metric in seven large German towns, tried to tons of chewing tobacco. From Sir deal with the smoking habit on the Walter Raleigh's time, customs have broadest possible basis, such as changed and even a religious furor counseling, group therapy, consideration about tobacco smoking was reported. of individual smoking habits, eating fruit, breathing exercises and hydrotherapy, effect a change and J 12215 prevent withdrawal symptoms.Immediate Jovanovic, A. and Toblasch, V. results (complete nicotine abstinence) DIE RAUCHGEWORNHEITEN DES DEUTSCHEN was 80 to 90 percent effective. Of 230 ANGESTELLTM4. (THE SMOKING HABITS OF interrogated individuals one to 2 years GERMAN EMPLOYEES.)Modizinische later, 50 to 60 percent were still non- Monatsechrift smokers. Rciain tmd 11WITM7)772-9,Zeitschiftfeu'allgeme Juline rgsrremn . J 12230 The pharmacological effects of soaking British Medical Journal. were reviewed. The smoking habits of SMOKING. British Medical Journal 3 patients with various disorders at a (5662, SupF177TS6,-M717,-11777- NeutrauchbureAllgau hospital, as wellas the reasons of the 'smokers for discontinuance of the smoking habit, were then

296 J 12250 J 12352 (continued) Medical Journal of Australia. a giant bonfire was echedulei to de- SMOKING AMONG SCHOOLCHILDREN. Medical stroy all cigars and cigarettes in town. Jlurnal of Australia 2(3):123-47=1 The idea originated when the town was 117-1W9. selected as the locale of the filming of a picture called, "Cold Turkey", the story of a millionaire who offered J 122E4 twenty-five million dollars to a small Lancet town if the inhabitants were to stop the WHY DO SCHOOLBOYS SMOKE?Lancet smoking habit. The mayor of the town 2(7623)3751, Oct 4, 1969. admitted that some of the inhabitants might prove too weak to maintain their VOWS. J 12336 Journal of the Royal Army Medical Corps. J 12364 TOBACCO AND THE SOLDIER. Journal Koller, S., Schmidt, F., and Krekel, L, of the Royt.; TMedicalAMY orep77- ARZTLICKER ARBEITSFREIS "RAUCHEN UND rThr37:104 GESUNDHEIT". (MEDICAL "SMOKING AND HEALTH" WORK GROUP.)Munchener Medizinieche Wochenschrift-111(32): J 12351 1631, Aug 8, 1969, German (Abs.) Jornal do Medico. 0 FUMO DOS CIGARROS COMO FACTOR This is an appeal to physicians IMPORTANTE DA POLUICAO ATMOSFERICA. intlrested in the formation of an (CIGARecrE SMOKE AS AN IMPORTANT FACTOR organization concerned with the IN AIR POLLUTION.)Jornal do Medico harmful effects of smoking. 69(1382):637, Jul 1971TVY,-PORTIFIree (Abs.) J 12369 The journal has commented on two Pennsylvania Committee on Smoking and the reports of the Royal College of Health of Youth and Leedman, C. L. Physicians which stated that excessive (Chairman). cigarette smoking increased the risks SMOKING AND HEALTH: THE PENNSYLVANIA of lung cancer, bronchitis and coro- STORY. Progress Report. Pennsylvania nary thrombosis. It was concluded that Department of Health, Harriaburgh, Pa., cigarette smoking was one of the more Apr 1969, 24 pp. important factors of air pollution. Even nonsmokers, particulaly those especially sensitive to tobacco smoke, J 12370 ran the riek of lung damage if breathing Weiss, W. air where smoking was permitted. The UNDERMINING THE SUBSIDY FOR PREMATURE British Government was reluctant to DEATH. Archives of Environmental take concete steps against the sale of Health l9(2):23u-r7 Aug 1969. cigarettes or the protection of nonsmokers in public places because of the currently high revenues from tobacco J 12373 products and because of the political Dies, R., Honeymen, M., Reznikoff, M., risks in offending operators of and White, C. theatres, restaurants and buses. PERSONALITY AND SMOKING PATTERNS IN Efforts to reduce the harmfulness of A TWIN POPULATION.Journal of cigarettes by lowering the tar and Projective Techniquer&-Me3Faliti nicotine content, as in the United Assessment 33(5):157-63, Oct 1969. States, were judged too feeble to cope with the lung cancer problem. J 12422 J 12352 Wohlford, P. and Giammona, S. T. Jornal do Medico. PERSONALITY AND SOCIAL VARIABLES UMA MADE INTEIRA VAI DEIKAR DE FUMARI RELATED TO THE INITIATION OF SMOKING (AN ENTIRE CITY WILL STOP SMOKINGI) CIGARETTES. Journal of School Health Jornal do Medico 69(1382):637, All 19, 39(8):544-52, Oct 196 Mr-P3FtWerd (Abe.) Greenfield, a small town in central Iowa, population 2,000 inhabitants, planned to stop smoking en mass, starting August 1, 1969. On that day,

291 ,yot J 12423 J 12476 Haro, M. S. and Dilley, J. W. Terry, L. L. THE AMERICAN COLLEGE HEALTH ASSOCIA- ClaARETTE PERIL KIT.Terry Highlights TION SMOKING AND HEALTH PROJECT. A Nurses' Workshop. AI News 16-17(3-1): National Survey of Attituies, 7-8, Fall-Winter 191,61-13n. Beliefs and Behavior Reg&,ding Smoking and Health on the Part of Undergraduate College Students. J 12481 Journal of School Health 2'.9(8): AE News. 356 31, tot 1969. TV LEARNING TO LIVE WITHOUT CIGARETTES. AE News 16-17(3-1)110-1, Fall-Winter 1-46Vr§69. J 12425 Medical Journal of Australia. SMOKING AND HEALTH: SOME WRIOUS J 12493 COMMENTS. Medical Journal of ArivE, C. D. Australia 2(14) :665 -6, Oct i7 1969. ON SMOKING AND71113USES OF ADVERSITY. Military Medicine 134(12)11455, Nov 1969.

J 12429 Yakeham, H. R. R. J 12498 FLOW THROUGH POROUS MEDIA EYMPOSIUM. Horn, D. Luncheon Address.Industrial & MAN, CIGARETTES, AND THE ABUSE OF ins ringcheroseirs17,710 =3, GRATIFICATION. International Journal Op the Addictions 4(3)5471-9, Sip

J 1244? J 12516 Lakartidningen. Goldenberg, I. S. and Stoll, B. LAKARNA OCH ROKNINGEN. {SM)KIHG AND TEEN-AGE SMOKING IN NEW HAVEN I.RESULTS TH MEDICAL PROFESSION)LNiartidningea OF AN IN -DEPTH SURVEY.Connecticut 66(2):116-7, Jan 8, 1969, gfedish (Abs.) Medicine 33(10) :629 -34, Oc 1969.

This consists of editorial comment which noted that ,Jigarette consumption J 12517 teas increasing despite growing evidence Connecticut Medicine. of the harmfulness of clgarctte smoking. SMOKING HABIT AMONG TEEN-AGERS. Swedish physicians were urged to help Connecticut Medicine 33(10)1605, their patientssiop amoking or greatly Oct 1969. reduce their cons mption of cigarettes. Efforts of the foleign press, particularly American megcal Journals, were J 12518 noted. Articles %ri Annals cf Internal Mandel, r. R. Medicine have urgad physicians to engage SMOKING AND HEALTH:THE PHYSICIAN'S more fully in antismoking campaigns by RESPONSIBILITY. Nassau Medical News disaemination of !information regarding 41(9):3, 12, Oct Mg:- the perils of sacking and actively as- sisting their pnllents in discontinuing the smoking habit.The fall issue of J 12537 Diseases of the (hest was devoted American Cancer Society. largely to the connection between ("1{E TEENAGER LOOKS AT CIGARETTE smoking and illness and to the role SMOKING "). American Cancer Society of physicians in this regard. A News Service, New York, N. Y., Nov reccamendation symposium reported 6, 1969, 11 PP. therein, urged tat each patient be interrogated regarding his socking habits, that he )e informed of the J 12538 risks in continuing the habit, and Newman, I. M. that he be advisad to atop snoking. THE SOCIAL DYNAMICS OF CIGARETTE SMOKING IN A JUNIOR HIGH SCHOOL. Ann Arbor, Michigan, University Microfilms, A J 12444 Xerox Company, 1969, 153 pp. Department of National Health and Welfare, Canada. CANADIAN CIGARETTE CONSUMPTIO1 DROPPING. J 12547 Department of National Health and Geriatrics. Welfare, Ottawa, Canada, Jul 15, 1969, SMOKING HABITS OF THE U.S. POPULATION. PP. 1-3. Geriatrics 24(11)160, Nov 1969.

298 302, J 12560 J 12622 (continued) McKennell, A. C. natural fermentation method, but in IMPLICATION FOR HEALTH EDUCATION OF that year, a new drying technique SOCIAL INFLUENCES ON SMOLINCI. was introduced in the United States American Journal of Public Health and the new method was then adopted and the NiEnTlinalth 51(11)iI398- by all countries with the exception M647-lov 1969. of the Union of South Africa, Poland and Russia. Twenty-five years later, the rise in lung cancer cases was quite J 12564 striking. The incidence in lung Thomas O. M. and Anthony, H. M. cancer however should be lower in SURVEY OF OCCUPATIONAL HISTORY AND the Union of South Africa, Poland BLADDER CANCER. British Empire and Russia, thanks to the method of Cancer 4Cerpl iimnfor Research, Annual curing tobacco. The author of this Report 12 6, TO. letter invites comment by asking, 'Is this fact or fiction ?'

J 12587 University of Natal, Department of J 12623 Pathology. Rosellini, A. D. (Governor). SURVEY OF CANCER INCIDENCE AMONG NATAL CONFERENCE ON SMOKING AND YOUTH. Seattle AFRICANS AND INDIANS. British Em e Civic Center, Seattle, Washington, Jun Cancer Campaipl for ResZIRE7-Annua 15, 1964, 39 pp. 117576. 46:386, 1378. J 12624 J 12592 Oarceau, R. British Medical Journal. SMOKINO AND THE TEENAGER.Governor's SMOKINO AT SCHOOL.British Medical Conference on Smoking and Youth, Journal 4(5674)16, Oct Seattle Civic Center, Seattle, Washington, Jun 15, 1964, pp. 9-11.

J 12611 Levitt, E. E. and Edwards, J. A. J 12625 A MULTIVARIATE STUDY OF CORRELATIVE Rice, K. B. FACTORS IN YOUTHFUL CIOARETTE SMOKING. FACE TO FACE WITH THE SMOKING PROBLEM. To be published in Develormental Governor's Conference on Smoking and Psycholam, n.d., 10 pp. Youth, Seattle Civic Center, Seattle, Washington, Jun 15, 1964, pp. 12-3.

J 12612 National Health and Medical Research J 12626 Council. Royea, D. REPORT OF A SURVEY INTO THE SMOKING HABITS COMMON SENSE TO TEENAGE SMOKING PROBLEMS. AND ATTITUDES OF AUSTRALIAN SCHOOL- Governor's Conference on Smoking and CHILDREN. By the ad hoc Smoking Survey Youth, Seattle Civic Center, Scattle, Sub-Committee. Extract from the Report Washington, Jun 15, 1964, pp. 14-5. of the 68th Session of the lational Health and Medical Research Council, Brisbane, Australis, May 15-26, 1969, J 12627 33 pp. Stenersen, S. FREEDOM TO SMOKE.Governor's Conference on Smoking and Youth, J 12622 Seattle Civic Center, Seattle, Krijgsman-de Bouve, W. Washington, Jun 15, 1964, pp. 16-7. CARCINCOENEN IN TABAKSROOK. (CARCINOGENS IN TOBACCO SMOKE.) NedvlandeTdschrift vv r_ J 12628 erAgskuAnd 2(22)t1046, Jun 1, Hundley, J. M. 1-1-68-,--5U-Oh(Abs.) TO SMOKE OR NOT TO SMOKE-YOUR DECISION. Governor's Conference on Smoking and The author refers to a book by the Youth, Seattle Civic Center, Seattle, English author, Eyeenck, "Smoke, Health Washington, Jun 15, 1964, pp. 19, 28 -33. and Personality", which stressed the importance of the manner in which tobacco leaf was processed. Until 1905, it was stated, all curing of tobacco was carried out by the

299 361 J 12629 J 12718 Carlile, T. Wehrle, P. F., B1:31t, R. L., Doyle, J. L., WHAT'S HAPPENING AND WHAT NEEDS TO BE Farr, L. E., Faga-, E. L., Finberg, L., DONEI Governor's Conference on Smoking Nahmiae, A. J., Pickering, D. E., Yamazaki, and Youth, Seattle Civic Center, Seattle, J. N., and Horton, R. J. M. Washington, Jun 15, 1964, pp. 27, 20-4. SMOKING AND CHILDREN: A PEDIATRIC VIEWPOINT. Pediatrics 44 (5, Part 1): 757-9, Nov 1969. J 12630 Bruno, L. SMOKE SIGNALS. Governor's Conference J 12725 on Smoking and Youth, Seattle Civic Zagona, S. V. and gabor, T. F. Center, Seattle, Washington, Jun 15, ADOLESCENTS' ATTITUDES TOWARD THEMSELVES 1964, pp. 35-7. AND CIGARETTE SMOKERS. Psychological Reports 25(2)3501-2, Oct 1969.

J 12631 De Witt Fox, J. J 12733 WHY NOT SMOKE? Washington, D. C., Review Smith, S. C. and Herald Publishing Association, 1968, HOW ABOUT SMOKING? Independent 128 pp. School Bulletin 27(21:50-62, Dec 1967.

J 12644 J 12754 Da Lucas, A. C. Canadian Medical Association Journal. MITOS, REMEDIOS Y REFRANES DEL TABACO, IT'S TIME OTTAWA LEGISLATED AGAINST A RELACIONADOS CON LA MEDICINA POPULAR. DEADLY HABIT. Canadian Medical Associa- (MYTHS, REMEDIES AND SAYINGS ON tion Journal 101(10)19-11773715, 1969. TOBACCO CONNECTED WITH POPULAR MEDICINE.) Medicamenta 26(455)3161-5, Sep 15, 1968, gpanish (Abs.) J 12755 Steins, L. The use of tobacco in the rites, THE ANTI- SMOKING CAMPAIGN. Nassau ceremonies and customs of the New Medical News 41(10):12-3, Nov-1969. World Indiana is describid. Tobacco was smoked, chewed and inhaled as powder or was used in the form of J 12801 hot compresses, enemae and concoctions Matzon, G. to alleviate pain, hunger, thirst, T. SZERUSZTOSEG. (LETTER TO THE intestinal disorders, worms, and EDITOR.) Orvoei Hetilap 101(5,): a host of other afflictions. From 2487, Dec 25, 1966, Hungarian (Abs.) a psychological viewpoint, tobacco was employed to stimulate the depressed, In a letter to the editor, Matzon G. to calm the excited and worried, and contradicts the claim advanced by differ- to loosen the spirit and facilitate ent signatories that tubercular or other conviviality. Adages and sayings patients confined at the State Sanatorium which have perpetuated myths of of Kekesteto (Matra Mts.) ars not tobacco concerning the virility and adequately informed concerning the social well-being of those who use pernicious effects of smoking. He it are discussed. believes that in our permissive times, to attach any importance to the abstinence of a doctor during his consulting' J 12705 appears to be rather optimistic. It Hochbaum, O. M. is regrettable that the prohibition of HOW CAN WE TEACH ADOLESCENTS ABOUT smoking for school age youth is not SMOKING, DRINKIrn AND DRUG ABUSE? enforced any longer.Still the sensi- In Resource Book for Drug Abuse tivity and the good sense of the youth Education. U. S. Department of could be stimulated by entertaining and Health, Education, and Welfare, informative lectures on the destructive Public Health Service, National effects of habitual smoking which pro- Clearinghouse for Mental Health gressively become irreversible. Primarily, Information, Chevy Chase, Md., it should be the task of the chemist to Public Health Service Publication eliminate the carcinogenic tar residue No. 1964, Oct 1969, pp. 21-4. and to decrease the nicotine content

300 3 04 J12801 (continued) J12803 (continued) to a practical placebo level. During with pulmonary carcinoma and confined both of the World ware and the subsequent at the State Sanatorium of Kekeeteto confinement in PW camps, the experience (Matra Mts.). has demonstrated that the craving for smoking is more of a psychological need than a physiological necessity. J 12804 A nicotine-free ersatz product would not Temesvary, E. Impair the national economy. Conversely T. SZERKESZTOSEO. (LETTER TO THE if the unlimited nicotine use (and abuse) EDITOR.) Orvosi Hetilap 107(52): is condoned, ad infinitum, then other 2487-8, DerW-1966, Hungarian (Abs.) alkaloids of lesser toxicity, i.e. cocaine, opium, hashish or other poisons In a letter to the editor, the 'legally and/or logically', should also writer, a former smoker who was forced to be made accessible to the public. discontinue smoking because of war inju- ries, states that he is educating his patients concerning the carcinogenic and J 12802 other pathogenic consequences or smoking. Rethelyi, J. He also calls attention to an indicting T. SZER OSEO. (LETTER TO THE work by Lickint, "Etiology and Pro- EDITOR. Orvosi Hetilm 107(52)s phylaxis of Pulmonary Cancer (1953)". 2487, Dec 25, 196G-Fritgarian (Abe.) Lickint has dedicated his work to the 100,000 to 200,000 Germans who within a In a letter to the editor, the decade, will be victims of pulmonary can- writer calls attention to the need for cer in their prime of life. The writer mandatory public education concerning regrets that most physicians are little the destructive effects of smoking. concerned with educating their patients Instruction should start at school age concerning the harmfulneee of the smoking levels. All promotional advertising for habit and do not hesitate to chain-smoke alcohol and tobacco should be Prescribed in the Presence of patients. for the protection and best interests of society. The writer does not advocate prohibition but Physicians are urged not J 12812 to smoke in hospitals or offices in the Szekacs, S. Presence of patients. A DOHANYZAS KERDESEHEZ. T. Szerkesztoseg. (ettREFLer ECTto ON THE PROBLEM OF SMOKINO.

L thIONSeEditor.) Orvosi :fettle J 12803 107(52)12485-6, Dec 25, 1966, Hunger an Szilagyi, L. (Abs.) T. SZERKESZTOSEO. (LETTER TO THE EDITOR.) Orvoel Heft 107(52): In a letter to the editor, Szekacs 2486-7, DeZ-757-1-966;-HUngarlan S. advocates nation-wide education on (Abs.) the deleterious effect of smoking which Preferably should be initiated in the In a follow-up letter to the editor youth. The clinical gravity of the ad- (of Fargo, J. Jul. 19643 Szekacs S. Jun. diction cannot be sufficiently stressed. 1965) Sztlagyi, asks for the assistance This woulo be the preliminary step to of the mass media in educating consumers, forestall all sorts of traumatic cancers concerning the insidious hazards of habit- and coronary and vascular complications. ual smoking. The passive transference The addicts to alcohol, morphine, caf- and imposition of emoke on nonsmokers can feine or to other stimulants or depres- be illustrated by the formation of 1-5 sants are ruining "heir health and are a Percent CO-hemoglobin, when the confined liability to their own family. Per contra atmosphere is saturated with 0.5 to 1 abstainers in a mixed congregation with Percent CO. Thie is a considerable notoriously inconsiderate smelters are liability to any metabolism. Objection rather passive-smokers not by choice but is also raised to the unfortunately- by imposition.The deleterious effect on designed and centrally-located corridors women of breathing air polluted pith in the new railway wagons. Thus pulmo- nicotine and other by-Products during nary patients or those with asthma or their Pregnancy has been recently reported. emphysema are quite encumbered with Insofar as the protection of general amok., in those compartments labeled health is concerned, the recently enforced for "nonsmokers onlyby the poorly ordinance by the Ministry of Railways and sealed swinging-door-system. Ethical Transportltion should be noted.According objection is raised ogainst those per- to this prelseWorthy act 50 percent of all missive slleagues who have not pro- public conveyances are reserved for scribed smoking for patients afflicted nonsmokers.

301 SOS J 12814 J 12821 (continued) Vodrazka, R., Svobodova, A., and also covr.red attitudes about smoking, Bartonova, M. estimates of improved health in those PRVZKUMNE SETRENI 0 ZDRAVOTNIM UVEDOMENI persons who ceased smoking, and physi- ZAKU SKOL I. A II. CYKLU, PEDA000IC- cians' opinion as to whether certain KYCH PRACOVNIKU A RODICU V OTAZCE diseases show a greater incidence of KOURENI. (INTERROGATION ABOUT HEALTH occurrence in patients who smoke. Medi- AWARENESS ON THE PART OF PUPILS IN cal opinion is mentioned on risk of PRIMARY AND SECONDARY SCHOOLS, THE diseases such as cancer in patients who TEACHING STAFF, AND PARENTS IN REGARD continue to smoke. Distinction is made TO THE SMOKING PROBLEM.) Ceakoaloicenaka between smoking cigarettes, pipes, or Pediatric 24(8):755, Aug 1969, Czecn cigars. Answers and opinions were (Abs.). compared with findings in other countries including the United States.Of the 1000 Statistical evaluation was made of persons questioned, 31 percent were non- data derived from a questionnaire an- smokers, 23 percent former smokers, and ewered by 1300 people, in connection 46 percent smokers. with their knowledge of health effects of smoking. Of the answers returned 1219 sets of answers were deemed reliable J 12843 and were part of the data analyzed. It Fuenning, S. I. (Project Director). was noted that pupile acquire the habit A PEER GROUP APPROACH TO A SMOKING of smoking at the secondary level, i.e., EDUCATION PRCORAM IN A UNIVERSITY in high school. Of the pupils who SETTING. University of Nebraska, acknowledged that they smoke regularly, Health Center Smoking Education it was determined that ages 13 and 14 Project, Lincoln, Nebraska, Jul 1, account for the greatest intensity and 1966-Jun 30, 1967, 76 pp. highest incidence of smoking. Pupils can be deterred from smoking only after they have been presented with concrete J 12844 evidence on the relationship between McFarland, J. W. (Chairman). smoking and disease. An aggravating A SUGGESTED SMOKING AND HEALTH PRCORAM factor in overcoming the habit is that FCR THE JEFFERSON MEDICAL COLLEGE AND parents at home show a permissiveness HOSPITAL.Smoking and Health Program. which the teacher in school cannot Presented before the Informal Committee overtone. Sterner measures on the part on Smoking and Health for Investigating of the government are recommended to a Program for Staff and Personnel of help students overcome the habit. Jefferson Medical Center, Philadelphia, Pennsylvania, May 23, 1967, 12 pp.

J 12821 Nowak, L., Tibblin, G., and Wilhelmsen, L. J 12845 SVENSKA LAKARES ROKVANOR. (SMOKINO Kirscht, J. P. and Chapman, R. E. HABITS OF SWEDISH PHYSICIANS.) SCME EFFECTS OF CONTROVERSY ON SUBSEQUENT Lakartidninpn 66(35)i3485 -94, 3531, SOURCE EFFECTIVENESS.University of Aug 27, 196v, Swedish (Abe.) Michigan, Public Health Practice Research, Ann Arbor, Michigan, March The questionnaire method was used to 1967, 15 pp. elicit facts from physicians in Sweden regarding their smoking habits. A statistical evaluation was made from data reported in the questionnaire that was circulated to 1000 memberc of the Swedish See also A 10832, C 12820, K 10529 Medical Association to which almost 90% of all physicians practicing in Sweden belong. Statistics were tabulated and are discriminated by age, sex, social statue (hospital chief, government physician, etc.) and field of specialization.Numerical values are also presented for physicians who had once smoked but later stopped.Values are also shown for factors such as number who expressed a longing to stop, and the reasons (medical, economic, or others) which prompted them to answer in this manner.Questionnaire answers

302 3'04) SECTION K. SMOKING WITHDRAWAL TREATMENT

K 10206 K 10412 Murovich, B. V. and Zvarich, V. A. Kalyuzhnyy, V. V. KC" -- CPEACT60 07 KYPEIW. PO DEKS'--SREOSTVO OT KURENIYA. PE4D4C TASAKOKYRDW C nopicumonosin'Am ("PONDEKSISMOKING DRUO.) BAARSE POSEJWAHABETETATVSMENCOCYANVIE Vrachebnoe Delo (8):151-2, Aug 1968, YiSTNIYE TABAKOKURENIYAS Russian (AbI7T POMOSEOWYU LOBELINA I VLIYANIYE LOBFL1NA NA VEOETATIVNYYE I I The reported success e Pondeks SOSUDISTYYE REAKTSII. (THE TREATMENT (2-amino-4-oxo-5-phenylozazolidine) OF NICOTINISM BY LOBEIINE AND ITS in smoking abstention at a Hungarian INFLUENCE ON THE VEGETATIVE AND institute led to its application in VASCULAR REACTIONS.)Zhurnal 49 men and 9 women smokers in the Lvov Nevro tol ii i PaikaiT7H68(12)1 area. Seven of the smokers were below is - , i 6 , Russian (Abs.) 30 years of age, 36 were between 31 and 50 years, and 15 were above 50 Lobeline therapy was applied in a years of age. All had regularly smoked 1 percent solution of hydrochloride to 25 -SO cigarettes delay; 20 had smoked 33 patients with nicotiniam. The for more than 20 years. Two to 3 treatment was given in intramuscular tablets of Pondeks were administered injections according to a certain for 3-7 days in a course of treatment. pattern. A control group consisting In 16 smokers, after 1 course of treat- of 20 patients with nicotinism was ment, an aversion to tobacco was treated with placebo with a full observed; these individuals did nut abidance to the element of therapy. smoke for 2-3 weeks; after another The achieved results permitted the course of treatment they did not smoke assessment of the influence of lobeline for more than 3 months and subsequently and the products of tobacco on the resumed smoking but at a reduced rate. organism of smokers.The data on which In 13 smokers, from the beginning of the evalua 4on was based were the treatment, a lowered tendency to smoking results of arterial oscillography and was observed but 3-5 days after completion sphygmography. They allowed compara- of the course of treatment they resumed tive data of vascular reactions and smoking at approximately the same pace the reactions of the vegetative nervous as formerly. In 7 smokers, the treatment system in the process of treatment and appeared completely ineffective. after. The conducted lobeline therapy made it passible for 33 patients out of 35 to stop smoking, while as in the ' 10283 control group out of 20 only 5 patients Monagle, W. J. and Tierney, J. T. stopped smoking. The author assumes RHODE ISLAND EXPERIENCE SHOWS HOW that the proposed method of lobeline A PARTNERSHIP FOR HEALTH PROGRAM therapy is reliable in the treatment of CAN SUCCEED. Journal of the nicotinism and recommends it for out- American Hospiril-MaTirrOn patient practice. (Author Abstract) 42(22):69-72, Nov it, 1968.

K 10413 10307 Benndorf, S., Kempe, 0., Scharfenberg, Carlin, A. S. and Armstrong, H. E., Jr. O., Wendekamm, R., and Winkelvoss, E. AVERSIVE CONDITIONING: LEARNING OR EROEBNISSE DER MEDIKAMENTOSEN DISSONANCE REDUCTION? Journal of RAUCHERENTWOHNUNO MIT CYTISIN (TABEX). Consultin and ClinicalPgUE;logY (RESULTS OF TOBACCO DETOXICATION BY : 87-15eo 1968. DRUGS WITH CYTISINE (TABU). Deutsche Oesundheitswesen 23i4a): 2092-6, Oct 1968, Oerman (Abs.) 10182 Lichtensteil, E. and Keutzer, C. After having introduced 'consulting BEHAVIOR MODIFICATION APPROACHES TO hours for smokers ready to undergo a SMOKING CONTROL. Speech Presented tobacco detoxication treatment' the at Western Psychological Association authors report on the initial results Meetings, an Diego, Cal., Mar 28, of a double blank test with cytisin- 1969, 7 pp. containing Tabex (0-tablets. So far 1452 smokers participated in this test. K 10413 (continued) K 10516 On the basis of 314 detoxication Wagner, M. K. experiments which have been fully A SELF-ADMINISTERED PROGRAMMED evaluatec the authors give a report RECORDING FOR DECREASING CIGARETTE now because of the broad public interest CONSUMPTION. Paper presented at in this problem. As far as we can Association for Advancement of the judge fron our statistically reliable Behavioral Therapies Meeting, San results, Tabex ranks first among all Francisco, Calif., Aug 30, 1968, 5 pp. meeicamentous aids of detoxication known so far, as it yielded a detoxication rate of 76.4 percent. K 10519 (Author Abstract) Wagner, M. K. and Bragg, h. A. COMPARING BEHAVIOR MODIFICATION APPROACHES TO HABIT DECREMENT- - K 10414 SMOKING.Veterans Administration Faun, D. and Franze, J. Hospital, Salisbury, N. C., 1969, RAUCHERENTWOHNUNG MIT CYTISINHALTIGEN 20 pp. " TABEX"-TABLETTEN. (TOBACCO CETOXICATION WITH CYTISINE-CONTAINING "TABEX" TABLETS.) Deutsche K 10525 Gesundheitswesen 23TTIMT68-91, Oct Farago, I. 1968, German (Abs.) ERGEBNISSE DER ENTWCHNUNGSKUREN VON 1125 RAUCHERN.Beitrag zum Three hundred and sixty-six Nikotinsucht-Problem. (RESULTS OF patients were treated with "Tabex" THE DETOXICATION TREATMENT OF 1125 (cytisin) in a tobacco detoxication SMOKERS. Contribution To The cure. The results achieved were Nicotinism Problem.) Schweizer significantly better than with 239 Archly fur Neurologla, patients treated with a placebo leuMocTrurWirnor-PMychiatrie compound. For patients suffering 102(1)a-67-89, TM, German TADS.) from hypertonia and arteriosclerosis the dose was reduced.Most patients Lobeline was administered to did not even need the whole cure- 925 and spiractin to 200 patients. package. Side effects were both minor Results of treatment were more and rare. "Tabex" ranks first as favorable with spiractin than with compared to other compounds on an lobeline. Resistance, ambivalence international level. The therapeutic and instability were viewed as success achieved-above all, the distinct signs of addiction and permanent success-can be essentially collectively they exerted a improved by group treatment. (Author considerable negative effect. A Abstract) smaller number of women participated than would be expected on the basis of smoker distribution. The daily K 10481 consumption of tobacco was lower Challenge. in women but the results in both FOR SMOKERS ONLY.Challenge :5, Jan sexes were equal. A smaller partic- 1969. ipation of the younger as well as of the above-fifty age groups was observed. The number of cures K 10504 was re'atively low in helpers Azrin, N. H. and Powell, J. as well as in mental workers and the BEHAVIORAL ENGINEERING:THE REDUC- addiction in both groups was quite TION OF SMOKING BEHAVIOR BY A pronounced. Heavy smoking was CONDITIONING APPARATUS AND PROCEDURE. noted in skilled workers but the Journal of Applied Behavior Analysis habit was amenable to modification. 1(3):1I3720, 19-687--- Only smoking-linked disorders such as cough, angina pectoris, loss of appetite or pain in the limbs which K 10507 directly caused physical pain or Wake, F. R., Andrews, D. A., and psychic aversion (fear, carcinophobia) Laughlin, T. J. were lasting incentives for treatment. REPORT TO TAE DEPARTMENT OF NATIONAL HEALTH AND WELFARE ON METHODS INVOLVED IN SUCCESSFUL AND UNSUCCESSFUL K 10528 ATTEMPTS TO STOP SMOKING. Department Lemin, B. of National Health and Welfare, Ottawa, THE FIVE DAY PLAN 10 STOP SMOKING. Canada, Report No. 305-8-24, Dec 11, A Report on a Smokers' Clinic Held in 19:7, 99 pp.

304 30? 10528 (continued) K 10782 the County Borough of Bolton. Health Wilhelmsen, L. )epartment, Civic Center, Bolton, ONE YEAR'S EXPERIENCE IN AN r-Igland, Oct 1967, 14 pp. ANTI-7Y^XING CLINIC.Scandinavian Journa_ of Nespiratory-aleiTg-rg(4): ZI=I7-13 1. K 10529 Schwartz, J. L. and Dubitzky, M. PSYCHO-SOCIAL FACTORS INVOLVED IN K 10869 CIGARETTE SMOKING AND CESSATION. Fredrickson, D. T. Institute for Health Research, ROW TO HELP YOUR PATIENT STOP SMOKING. Berkeley, Calif., Final Report of the Bulletin National Tuberculosis and Smoking Control Research Project, TITM=.aoTrsrals Aaeociation 55(4)1 Sep 1968, 680 pp. 6-11, Apr 1969.

K 10533 K 11140 Keutzer, C. S. Lichtenstein, E., and Cohen, S. B. Rees, H. L. HYPNOSIS AND SMOKING. Journal of the MODIFICATION OF SMOKING BEHAVIOR: (A American MedicalA e aloe iirrarrolr217- Reviet Psychological Bulletin 70(6, 31T7r,rpF-rr,n9613= part 1 :520-33, Dec 1968. K 11258 K 10552 Udall, X. A. Fredrickson, D. T. C/OARETTE SNDKINQ AMONG MEDICAL STUDENTS. HOW I HELP PEOPLE STOP SMOKING. (Special Artiele)Current Therapeutic Hosoital Physician :52-6, Apr 1968. Research 11(5)1316-157r91§69.

K 10562 K 11367 Trahair, R. C. S. Cinquini, U. MOTIVATION TO GIVE UP CIGARETTES: IL SOLFATO DI LOBELINA NELLO SVEZZAMENTO PROBLEMS AND SOLUTIONS.Medical DAL TABAOISMO. (LOBE LINE SULFATE IN Journal of Australia 1(4):177-80, GIVG UP THE SMOK HAB. mr2-57 r169. PoliIcNlinic° 76(12):37ING8-83,IT Ma)r 24, 1969, rtatian (Abe.)

K 10579 The author managed 80 smokers by Platt, E. S. lobeline sulphate and antiacld drugs. ROLE PLAYING AS A TECHNIQUE FOR The results he obtained were very good CHANGING CIGARETTE SMOKING BEHAVIOR. for giving up the habit of 'hooking and Presented at EPA meeting in Washington, for the absence of functional alterations D.C., Apr 18, 1968, 20 pp. or toxic phenomena. (Author Abstract)

K 10610 K 11412 Sapin-Jaloustre, H. Lichtenstein, E. and Xeutzer, C. S. A PROPOS DES PRODUITS "ANTI-TABAC". EXPERIMENTAL INVESTIGATION OF DIVERSE (ON ANTI-TOBACCO PRODUCTS.) Concours TECHNIQUES TO MMIFY SMOKING' A FOLLOW- Medical 90(46):7765-6, Nov 16, 196, UP REPORT, Behaviour Research and IFFEFE(Abs.) Lamm 7(1):139-40, pn-mr77 An inquirer, who was a physician, had asked for information concerning K 11495 anti-tobacco products on the market. Bernstein, D. A. In reply it was stated that such MODIFICATION OF SMOKING BEHAVIOR: products had relative efficiency, were An Evaluative Review. Psychological harmless and had no contraindications. Bulletin 71(6 }:418 -40, Tun 1964. The reply also referred to the 5-day plans for ambulant anti-smoking treatment and a book by Wayno MacFarland K 11507 for patients who could engage in self- Williams, H. O. detoxication without drugs. It was ROUTINE ADVIJE AGAINST SMOKING. A also suggested that a complete bibliogra- Chest Clinic Pilot Study. phy might be available from a Dr. Maud Practitioner 202(1211):672-6, May Cousin in Neuilly-sur-Seine. 1969.

303 3D? K 115 81 K 11852 (continued) Westchester Medical Bulletin. uation aids known at present. We SMOKERS' WITHDRAWAL CLINIC.Westchest- express our wish to make this compound er Medical Bulletin 37(4)117 -17narms. available for medical prescription to large circles of interested doctors as soon as possible. (Author Abstract) K 11666 Hartman, B. J. GROUP HYPNOTHERAPY IN A UNIVERSITY K 11910 COUNSELING CENTER.American Journal Batchelor, E. D. of Clinical HyTmosicinITTIT6777---- STUDENT SMOKING WITHDRAWAL CLINIC. 7U1 1969. Bulletin of the Pennsylvania Tuberculosis WrIerrtE-SFETety5114)15,8MT-Au=g; K 11696 TM. Jenks, R., Schwartz, J. L., and Dubitzky, M. K 12036 EFFECT OF THE COUNSELOR'S APPROACH TO Schwartz, J. L. and Dubitzky, M. CHANGING SMOKING BEHAVIOR. Journal MAXIMIZING SUCCESS IN SMOKING of Counselled Psychology 16(37721S721, CESSATION METHODS. American Journal of Public rgEv. Health and-M-RiticTITTRIallh-011371

K 11810 Grant, M. K 12229 SMOKING AND HEALTH.Medical Annals of U.S. Medicine. the District t of ColumblE-3116173797 HYPNOSIS ADVOCATED FCR HEAVY SMOKERS. U.S. Medicine 5t16):8, Aug 15, 1969.

K 11852 K 12249 Benndorf, S., Scharfenberg, 0., Kempe, 0., Fredrickson, D. T. Winkelvoss, E., and Wendekamm, R. HELP YOUR PATIENT STOP SMOKING. WEITERE MITTEILUNGEN USER EINFA Guidelines for the Office Physician. DOPPELTEN BLINUVERSUCH MIT DEM Minnesota Medicine 52(8)11319-26, CYTISINHALTIOEN BULOARISCHEN PRAPARAT Aug MR. TABEX AN 12:4 ENIWONNUNGSWILLIGEN RAUCHERN UND PRAKTISCHE ERFAHRUNGEN BEI DER DURCITUHRUNO EINER SPRECHSTUNDE K 12387 FUR ENTWOHNUNGSWILLIOE RAUCHER. whitmen, T. L. (FURTHER REPORTS ON A DOUBLE-BLIND MODIFICATION OF CHRONIC SMOKING TEST WITH THE CYTISLNE-CONTAINING BEHAVIOR: A COMPARISON OF THREE BULGARIAN PREPARATION TABEX ON 1214 APPROACHES. Behavior Research and SMOKERS WISHING TO BREAK THE HABIT Therapy 7(3)teo7=63, SITIFT7g77 AND PRACTICAL EXPERIENCES IN THE OPERATION OF A CONSULTATION HOUR FOR SMOKERS WISHING TO BREAK THE HABIT. K 12389 DeutscLe Oseundheitswesen 24(24)11135-40, Grimaldi, K. E. and Lichtenstein, E. 75777.71969, German [ADS.) HOT, SMOKY AIR AS AN AVERSIVE STIMULUS IN THE TREATMENT OF SMOKING. Behavior On the basis of the results Research and Therapy 7(3):275-327-M- achieved with 1214 subjects, the authors rfg77--- report on a double random teat with the cytisine-bearing compound tabex (R) within our consulting hours for K 12430 smokers willing to undergo a cure to Caldwell, E. get rid of habitual smoking.They HOW YOC CAN STOP SMOKING...PERMANENTLY. define their views on the suitability Hollywood, California, Wilshire Book of the compound as a medicamentous aid Company, 1966, 96 pp. to make chronical smokers abstain from smoking. The present level of these possibilities, as well as the authors' K 12458 own knowledge of the consequences re- Mayer, N. sulting from such cures are discussed HYPNOTISMTO CURE SMOKINOIMYSTERIES AND and demonstrated, considering the well- MISUSE. known relevant literature. ax.York 2(33)128-33, Aug 18, As we can 1969. judge from our own experience, tabex (TO should rank first among all dehabit-

306 3/0 K 12471 Fredrickson, D. T. HOW TO HELP YOUR PATIENT STOP SMOKING. Journal of the Medical Association of MIUT:01-5, Oct 1969.

K 12557 Lincoln, J. E. WEIGHT GAIN AFTER CESSATION OF SMOKING. Journal of the American Medical Asi7aTiEfoW-2M9):1765, 1W171969.

K 12590 Berglund, E.-L. A FOLLOW-UP STUDY OF THIRTEEN NORWEGIAN TOBACCO WITHDRAWAL CLINICS. The Five- day Plan. Final Report. The Norwegian Cancer Society, Huitfel6sgt. 49, Oslo, Norway. Aas & Wahls Boktrykkeri, 1969, 67 pp.

X 12610 Lichtenstein, E. and Keutzer, C. S. MODIFICATION OF SMOKING BEHAVIOR: A LATER LOOK. Presented at the Third Annual Meeting of the Association for Advancement of Behavior Therapy, Washington, D. C., Sep 1, 1969, 23 pp.

K 12641 Ejrup, B. E. V. REPORT FROM THE TOBACCO-WITHDRAWAL CLINIC AT THE NEW YORK HOSPITAL- CORNELL MEDICAL CENTER. Presented at the World Conference on Smoking and lealth, New York City, New York, Sep 41-13, 1967, 19 pp.

See alsoA 11541, J 10391, J 10806, 71151242

307 3W INDIVIDUAL AND ORGANIZATION INDEX

Aas, B., J 10948 Aabenelli, U., F 10458 Actin, T. W., D 12018, D 12081 Abbsai, A. S., E 10810, E 12115 American Academy of General Astrup, P., E 10603, E 10604, Abdul Wahed, A. K. M., E 12743 Practice, J 10569 E 11058, E 12238 Abdulleev, R. A., E 11832 American Cancer Society, Atteli, J.-R., E 11358 Abel, H., E 11718, E 11856 8 12519, C 10508, J 12537 Aubert, J., C 10701 Abel, H., E 12553, E 12554 Amick, J.-L., A 11220 Aubertin, E., C 11213 Abelin, T., C 10669 Anoe, H. E., Jr., J 11419 Audier, X., E 11933 AbernetLy, G. S., A 12310 AncLev, N., B Auerbach, 0., A 10292, A 11229, Abou-Deoud, K. T., 0 12721 Andelman, S. L., E 10741 C 11777, D 10220, D 11749, Abramson, D. I., E 10887 Anderis, M., E 11355 J 10296 Arms, B. E., A 10374 Andersen, I. B., C 11101 Austen, K. F., D 12101 Abulafia, J., C 11920 Andersen, R. A., A 10789 Aviado, D. M., A 11153, A 11298, Aceto, H. D., F 12479 Anderson, A. E., Jr., D 10719 A 11440, D 11611 Acheson, R. H., E 10996 Anderson, C. K., C 12272 Avis, P. R. D., E 12345 Acne, L., C 11858 Anderson, D. L., 8 11433 Avril, P., 11 11773 Acuff, H., A 10928 Anderson, T. N., 8 11312, D 10559 Avtandilov, G. C., E 11376 0., A 10492 Anderson, W. H., D 10716, D 12797 Ayre, J. E., C 11980 Adaniker, D., A 11768 Andor, L., C 11930 Ayres, S., Jr., F 11919 Adame, C. N., D 10551 Andreolt, H., E 10327 Ayres, S. M., D 10590, E 11154 Adam, C. V., E 10648 Andreu, L., C 12521 Azrin, N. H., K 10504 Adamthwaite, S., A 10971 Andreu Horate, J. Ma., C 12521 Ahmed, N., E 12115 Andrews, D. A., K 10507 Ahmeteli M., E 10514 Angermann, G., J 10497 Ainley, R. G., F 12153 Angulo, M., A 10561, A 11808 Aitio, A., A 10260 Mitts, N., A 11165 Akaike, S., A 10310, A 10311, Anjuere, J., E 10619 A 10312, A 10313, A 10314, Anlyan, A. J., C 12785 Babarczy, G., D 11301 A 10315 Ansari, I., D 12070 !labor, T. F., J 10394, J 12725 Akimova, R. N., A 12468 Ansorg, R., F 12208 Babyak, H. A., A 11130, D 11105 Akoun, C., C 12130 Anthonlsen, N. R., D 11699, Backhouse, C. I., J 11802 Akau, S., A 12049 D 12079 Bedgett, C. E., A 11063 Alarcon, D. C., C 12169 Anthony, H. M., J 12584 Badre, R., A 10474 Albanese, A. A., A 10384 Anthony, P. P., A 11149 Baedecker, M. L., A 10587 Albereen, E. D., F 11454 Apidienakis, J. C., A 12474 Helical, A., D 11274 Albert, R. E., r 1C293, D 10977, Aroma, F., F 12691 Beide, H., P 11981 D 11494, D 12703 Archer, F. L., A 10868 Unit, H. L., C 12412 Albo, J. F., A 11168, A 11177 Archer, V. E., B 11586 Bair, W. J., A 11474 Alceide, A., A 11961 Arghyroudis, D., A 11163 Baird, J. A., A 11474 Alexander, E. R., E 12350 ArCrett, I. C., A 10961 Baker, J. R., A 11978 Alexander, 1. K., E 12061, Arhan, P., A 12453 Baker, H. S., A 12481 E 12497 Arifkhanova, S. I., E 11378 Lalars, T., A 11803 Alexander, P., C 11528 Arise, M., C 10430 Baldwin, R. W., A 11097, A 12671 Alford, E. D., A 11064 Aring, C. D., J 12493 Balenko, N. V., C 11762 Alfred, L. J., A 12483 Armitage, 1. K., A 10558, A 11486, Balis, M. E., A 11595 Aliso'', V. A., F 12819 A 12113 Ball, J. D., D 12015 Alivirta, P., E 12244 Armstrong, H. E., Jr., K 10307 Ball, J. K., A 11020 Allen, A., C 12260, D 11481 Arndt, J. H., C 10246 Ball, K. P., E 11883 Allen, H.,.1 10670 Arnold, C., A 10545, J 10320 Belldin, B., A 12436 Allen, J. D., D 12101 Aronov, D. M., E 10422 Ballenger, J. J. D 10717 Allen, W. A., J 10497 Aronov, W. S., D 11798, E 12228 Balloun, S. L., E 12279 Alli, A. F., F 12467 Aronson, S. H., E. 11408 Wog, B., E 12185 Allison, P. R., E 12082 Arsenyen, E., A 11189 Belts, H. J., E 10797 Allison, R. D., E 11779 Arter, W. J., F 10972 Bang, F. B., C 10815 Allman, D. R., A 11211 Arto Shshrik, H., A 12633 Bankart, C. P., C 10798 Allt, W. R., A 10553 At...tilde'', F. D., A 10531 Bennikov, G. N., A 10808 Aloneo, J. L., E 10477 Ashley, D. J. B., C 11544, C 11656, Bayne, B. C., C 12008 Alonso, J. M., C 11352 C 12016 Baratta, E. J., A 12474 Alpers, J. H., B 11558 Ashmarin, I. P., A 12555 Barber, H. R. K., C 10693 Altmann, H., A 11768 Asmundsson, T., D 10965, D 11438 Berber°, A., D 11673 Amaral - Hendee, J. J., A 11918 Assal, N. R., B 12398 Barbier, M., A 11961 Amatunyan, V. C., D 11871 aztapova, S. A., A 12707 Barclay, W. R., D 10902

308 340 Satiety, X., C 11543 Belyayev, I. 1., E 11591 Strath. G., D 10739 Barkemeyer, H., A 11287 Benack, R. T., E 10793 Bisbini, P., B 11746 Basket, C. R., A 11097, Benatti, G., C 11279 Bitch, X., C 11971 A 12671 Bendich, A., A 12010 Bischoff, P. C 11915 Barlow, R. B., A 12758 Benedict, R. C., A 10476 Bisetti, A., C 11745 Baron, F., C 11693, C 12452 Benndorf, S., X 10413, X 11852 Bismuth. C., I 11540 Baron, J., A 12299 Benner. J. F., A 12180, A 12340 Bissanti, A., A 11033, F 10818 Barr, G., E 11695 Bennett, A., A 11082, A 12121 Bjartveit, X. J 10948 Barrage, B. C., A 12418 Bennett, D. E., B 10999, C 10652 Bjelke, E., C 11694 rattillon, A., E 12041 Bennett, M., P 11111, (see also Bjerkelund, C., E 12188 Barron, K. D., C 11906 Bennett, H. E.) Blachly, P. H., E 12277 Barry, E. .1,, A 11891 Bennett, M. E., C 10466, (see Black, D. X., A 12620, A 12661 Barth, n.. D 11038 also Bennett. H.) Black, L. F., F 12420 Bartle, K. D., A 12424 Bennirghoff, D. L. A 1276i Blackburn, C. R. B., F 10972 Bartlett, D., Jr., A 11610 Bennington, J., C 10945 Blackburn, J. V., A 12418 Bartlett, G. C., C 11252 Bentley, H. C., F 12479 Blacksore, H., A 12681, A 12682 Barton, R. T., C 11817 Berard, Ii, J., D 10456 Blackwell, R., A 11645 Bartonova, H., J 10766, J 12814 Berdichersky, R., C 11920 Blagojevic, M., A 11179 Bartsch!, R., D 11876 Bererson, G. S., E 11430 1471r, A. E., C 1091D Barua, K., F 11563 Berglund, E.-L., X 12590 Blair. W. M.. D 10505 Barsilai, D., B 11547 Bergman, F., C 1Q980 Blenkinsop, W. K., A 12666 Basile, E., A 11176 Bergmann, E. D., A11584 Bloch, D. A., C 12416 Bass, H., D 11699, D 12079, Bergonsi, H., A 10879 Block, D. L., D 10594 (see also Bass. H. E.) Bergatermann, H., D 11018 Bloetbergen, H. C. P., C 12226 Burl, H. E., D 12406, (see Beritic, D., A 12822 Blohmke, M., D 12503, E 10204, also Bass, H.) Berkson, D. H., E 10783, E 11695 E 11738, E 11856 Bass, P., A 10386 Bernard, P. J., A 11615 Blokhine, N., C11950 Bassett, D. R., E 10641, Berndt, H., 8 10927, C 10930 Bloom, H. J. G., A 12574, A 12650 E 10878, E 12351, E 12554 BernaDeier, A., E 12510 Bloor, C. X., E 10799 Batchelor. E. D.. K 11910 Bernstein, D. A., K 11495 BImchen, G., E 11466 Bates, D. V., D 10596, Berry, G., D 12015 Blume, W. 7., C 10898 D 11699, D 12079 Bersohn, 1., E 11638 Blundi, E., C 12500 Bates, W. W., A 10372 Bertalanfly, F. D., A 12000 Bocevski, D., A 11195, A 11196 B ettis, K., G 11484 Berti, F., C 11744 Bock, F. G., A 10222. A 10488, Bauer, K. H., C 11006, C 11725 Bertram, J. S., A 12585 A 10936, C 10219, C 10291, Baumann, H. R., D 11951, Peel'. G., C 10124 D 12078 Best. H. H. E 11401 Bojekle012,4:F 10682 Baumann, P. C., E 12221 Betts, T.. A 12561 Bockmar, D. E., A 12470 Baumeister, R., A 10872 Beuving, L. J., A 12719, A 12720 Boger, E., A 10239 Baxter, H. D., D 11437 Bevan, J. A., A 12411 Bohlau, V., D 12203 Bearden, J. H., A 11014 Bhagat, B., A 12695 Boin, J. K., D 10566 Beattie, E. J., Jr., C 12793 Bhandari, M. H., E 10992 Bolan, 0., L 11023 Beaumont, J. L., A 11770, Bhansali, S. K., C 12003 Boles, R., C 11633 E 12027 Bharadwaj, V. P., A 11616 Bolotova, H. N., A 12818, E 11811 Beck. I., B 11425 Bhargava, L. P., A 11003 Bonaccorso, O., D 10468 Becker, E. J., A 11084 Bhargava, S. P., C 11979 Bond, B.A 11257 Beese, D. H., H 10483 Masker Rao, P. A., C 10968 Bonollo, L., A 11508 Beffinger, J., J 11761 nett. V., C 11979 Bonier, G. M., A 11156 B eg, A., E loan, E 12115 Bhowv, A. S., A 12740 Booth, J., A 12567, A 12638 Behrendt, H., A 12546 Biancifiori, C., A 11546, C 11635 Borden. A. C. B., E 10888 Bekker, 0, H., E 11378 Biersteker, K., C 12226, D 10780 Boren, H. G., A 12095. D 12065 Belanaric, J., B 12281 Rignon, J., D 11570 Bolenirsund, E., A 12010 Beldin, R. A., C 11976 Bigotto, H. R., B 11746 Borgatta, E. -., G 10664, G 10665, Bell, C., A 11139 Bilictki, F., B12809 J 10677, J 10678 Bell, J. A., A 10447, (see Bils, R. F., D 12056 Borisyuk, Yu. P., A t2131. A 12817 also Bell, J. A. E.) Binet, E 12041 Bonner, P., A 11756 A. E., B 12150, Bing, R. J., E 11250, E 12200, Worrell, J. L., D 11409 J 11421, (pee also Bell, E 12447, E 12796 Borges, T., A 12178, A 12179 J. A.) Bingham, E., A 12698 Borum, X., A 11997 Bell, J. R., C 11890 Binopoulos, X., A 11163, (see also Boska, D., A 10625 Ballet, S., A 10777, A 11085, Binopoulos, X. E.) Bottomley, A. C., F 12153 A 12795, A 12798 Binopoulos, X. E., A 11203, (see loucot, K. R., C 11668 Gelman, S., A 11892 also Binopoulos, X.) Boudik, F., D 10801, D 12805 Blot, N., D 10475 Bouhuys. A., D 11671, D 11682, D 11992, D 12688

309 Bourali, C., A 12012 Bruce, R. A., E 12350 Bynner, J. M., G 11698, J 11806, Bourgeois, N., D 12055 Bruggemann, W., E 12185 (see also Bynner, J.) Boutwell, R. K., A 10934, Brugsch, H., A 10837 Bywater, R. J., A 12329 A 12484 Brummer, P., B 12324 Hover', T C 10772 Brun, J., D 10475 Bovet-Nitti, F., G 11122 Brune, H., A 11758 Bowden, P. U., D 10775 Bruneau, Y., C 11693 Bowden, T. , A 12484 Brunel, M., D 11464 Bowles, W. T., C 10981, F 10288 Bruno, L., J 12630 Bowlin, J. W., C 12120 Bruno, M. S., C 12341, C 12409, Cacciari, P., A 11535 How, 0. H. ,J 10599 E 12251 Cady, B., C 10750 Boyaner, H. G., E 10970 Brunswick, A. F., J 12151 Cady. L. D.. E 10570 Boyce, W. H., C 11115 Bruschke, G., D 12434 Caffe, P. J., C 11964 Boyland, E., A 10334, A 12563, Bruton, J. W., A 12684 Caffrey, B., E 12111 A 12567, A 12638, A 12653 Bruze, m., A 10986 Cagan, S., F 11000 A 12687 Bryan, G. T., A 12007, C 10606, Caganova, A., F 11000 Boyle, C. H., J 10253, J 11521 C 12393 Cohan, W. G., C 12770, D 10330 Boyle, E., Jr., E 10257 Bryson, G., C 11915 Cain, W., E 12748 Bozyk, Z., E 12515 Bubsnj, D., E 11044 Caldwell, E., K 12430, (pee Brace, F. C., 1 10478 Bucciarelli, E,, C 11635 also Caldwell, E. J.) Bradess, V. A., E 10537 Bucher, U. W., E 11092 Cildwell, E. J., D 12071, (see Bradshaw, E., C 11776, C 12374, Bucher, U., D 10803 also Caldwell, E.) C 12386 Buchner, Ch., E 11466 Calendi, E., A 10946 Bragg, R. A., K 10519 Buell, P. E., C 11566 Callaghan, R. S., C 10683 Brain, J., A 12089, (see Bueno, Z., C 11594 Calvert, J., A 10376 also Brain, J. D.) Bugaieski, S., D 10348 Calvet, J., C 10700 Brain, J. D., D 11992, (set Buhler, V., C 11642 Camber, P. J., A 11440 also Brain, J.) Bulian, T., C 11578 Cameron, J. D. H., A 12305 Braja, H., A 12512 Bullock, B. C., E 10959, E 12146 Cameron, P., B 11407, (see also Bras, G., C 12677 Buncher, C. R., r 11226 Cameron, P. D.) Brett, G., E 11441 Burch, R. R., E 10797 Cameron. P. D., D 10513, (see Braun, P., D 12846 Burchett, P., F 10972 also ;:ameron, P.) Brew:weld, E., A 12794 Burdette, W. J., A 10339 Campbell, C. B., C 10401 Brent, R. L., J 12718 Burdick, D., A 12180, A 12340 Campbell, U., B 11877, (see Breuer, J., D 12406 Burdman, D., A 12761 also Campbell, H. 6.) Brief, Gh., A 12396 Burford, T. H., B 10999 Campbell, H. E., A 10364, (see Briggs, C. D., A 10634 Burgess, A. M., Jr., J 11994 also Campbell, H.) Brighetti, A., J 10321 Hurkey, F., E 10783 Campese, V. M., A 12446 Bright, C. C., A 11232 Burk', H. R., A 12337, A 12690 Camplong, L., E 12110 Brignani, F., D 11839 Burkitt, D. P., C 10686 Canale, N., E 12343 Brimblecombe, R. W., A 11245, Burklt, O., A 12540 Candell, A., A 12454 A 12418 Burnell, D., C 11534 Candlort, R., C 12129 drin%man, G. L., D 10594, Burney, S. W., C 10560, C 11890 Canepari, C., D 12026 D 10596 Burnt, B. H. G 10639 Capaldi, E., E 10319 Briscoe, W., D 10977, D 12703 Burns, J. 3.. A 12381 Capitaine, Cl., D 10189 Britt, R. C., D 11438 Burns, L. C., A 12594 Capronnier, C., C 11543 Brocard, U., C 12130 Burns-Cox, C. J., E 11883 Caratti, C. A., D 10695 Bronshteyn, Ye. I., F 10548 Burrows, B., D 10723, D 10762, Carbone, P. P., A 11975 Bronte-Stewart, J., F 11822 D 12100, D 12487 Cardon, R., D 11438 Brookes, P., A 10487, A 12562, Burton, H. R., A 12180, A 12340 Carducci, R., D 12070 A 12564, A 12637 Burson, P. A., D 11141 Careddu, P., A 11032 Bross, I. D. J., C 10216, Burvill, H. J., E 11734 Carlile, T., J 12629 E 10262 Busatti, L., B 11368 Carlin, A. S., K 10307 Brown, D. A., A 11066, A 11349 Buser, H., A 10951 Carlson, 0. H., A 10386 A 12739 Bush, R. D., E 12149 Cerhon, L. A., E 11223 Brown, D. P., A 11474 Butler, N. R., F 11454 Carlton, W. W., A 10464 Brown, G. B., A 11255 Buturlin, V. V., D 10807 Carney, R. E., A 12472 Brown, H., E 11379 Buu Hoi, N. P., A 10194, A 11937, Carnow, B. W., D 10978 Brown, N. J., C 11482 C 11947, C 11970 Caro, C. G., E 12276 Brown, R., F 11311, (see also Buena, E., C 12808 Carretti, D., D 12026 Brown, R. I. F.) Byerrum, R. U., A 10350, A 12594 Carrillo, L., A 11153, (see al5) Brown, R. I. F., C 11113, Bynner, J., J 11643, (see Carrillo, L. R.) C 12460, (see also Brown, R.) also Bynner, J. M.) Carrillo, L. R., A 11298, (szc Browning, R. H., J 0790 also Carrillo, L.) Brownlee, K. A., B 10375 Bros, V., B 12133

310 3 / 4 Carrington, C. B., D 12067, Cheater, E. H., D 11281 Coleman, H. N., A 12794 E 12060 Cheater Beatty Research Institute, Coll, J., C 10700 Carrington, M. J., A 11139 A 12660 Colley, J. R. T., D 11293 Carroll, F. I., A 12310 Chhabra, M. L., E 10992 Collins, B., D 12077 Carter, L. J., 1 11400 Chiancone, F. M., A 11031, Collins, G. B., A 12764 Carter, R. L., A 10971, A 11099, A 12508 Collison, H. A., E 10568 A 12566 Chiang, B. N., E 11793, E 12350 Coltoiu, D 11532 Carugno, N., A 11174, A 11202 Chiavaro, A., E 11752 Comer, E. 0'B., E 10797 Casar, F. P., E 10477 Chiculeacu, 0.. A 11533 Conklin, M., A 12712 Casarett, L. J., A 10231 Chiou, C. Y., A 12724 Connelly, R. R., B 10465 Case, R. A. M., B 12558, C 12741 Chiricuta, I., A 11023 Conney, A. H., A 10377, A 11102, Case, A. S., C 11115 Chisholm, I. A., F 11822, F 12415 A 12602, A 12747 Cassel, J. C., F 12312 Chiurco, G. A., C 11740, C 11748 Conover, A. G., I 10409 Cassidy, E., B 12680 Choi, Y. Y., E 11286 Conroy, J. P., B 11242 Castagnoli, N., Jr., A 12119 Chokroverty, S., C 11906 Conte, A. J., C 12771 Castelli, W. P., E 10213, Chomet, B., C 10763, C 12692 Conti, E., B 11368 E 12263 Chortyk, 0. T., A 10527 Conzelman, G. M., Jr., A 11291 Castleman, B., C 12325 Chouroulinkov, 1., A 11905 Cook, P. J., J 11237 Caatrillon-Oberndorfer, W. L., Chouteau, J., A 11162, A 11164, Cooke, R. A., C 11123 F 10318 A 11168, A 11177 Coombs, R. R. A., A 12716 Castro Sontos, Lycurgo de, Jr., Christakts, C., E 12248 Coon, W. W 3 11419 F 11217 Christensen, B. Chr., C 11016 Cooper, D. A., C 11668 Catlin, D., C 10750 Christian, E. C., C 12466 Cooper, D. L., B 12280 Cattan, A., C 11869 Christian, P., E 11028 Cooper, E. H., C 12272 Cavallaro, G., D 10416 Christie, G. S., A 11248 Cooper,3. E., A 10935 Cavalli, A., D 11839 Christie, N., J 10948 Cooper, J. T., A 10230 CasamaJour, F., A 11177 Chrean, H., A 12028 Copeland, K., C 10501 Ceballoa Uriarte, A. M., C 11219 Chung, C. S., E 10878 Corbaz, R., A 11182 Cebollada, J., E 11355 Churchill, W. H., Jr., A 12379 Cordonnier, J. J., C 10981 Cecchetti, E., D 12825 Cinquini, U., K 11367 °OREM, A 11161 Cecchini, M., C 10696 Ctocco, A., B 11805 Corley, K. C., Jr., C 10385 Cederlof, R., A 11059, B 11299, Ctttadini, A., C 11858 Cormack, W., D 11293 E 11042 Civatte, J., C 10704 Cornfield, J., E 12296 Cerny, M., F 11512 Civiero, C., E 11370 Corothers, T. E., E 10280 Cha, J. V., C 10618 Clsgett, 0. T., C 10424 Corradi, C., C 11526 Chabea S. A., B 11864 Clapp, N. K., A 11646, A 12685 Corrcll, N., C 10763 Chacko, K., E 11990 Clark, C., J 10759 Cossu, F., C 11854 Chadwick, D. R., D 10555, Clerk, M. S. C., C 11081 Cotes, J. E., F 11783 J 10383 Clark, R. L., C 12830 Coudray, P., D 12037 Chaftian, Y., C 10925 Clark, T. W., B 11792 Courbier, R., E 11354 Chaplin, A. V., C 1089; Clarke, W. G., D 12015 Coury, Ch., C 11957 Chakraborty, M. K., A 10903 Clarkson, T. B., E 10959, E 12146 Cowan, C., E 11250 Chalmers, J. G., A 12675 Clavenzani, E., C 11471 Cowan, G. A. B., B 10988 Chamberlain, W. J., A 10408 Clayson, D. B., A 11156, A 12583 Cowdry, E. V., C 11387 Chamorro, A., A 12601 Clemens, J. A., A 12313 Cox, C. E., C 11115 Champy-Hatem, S., A 11967 Clemmesen, J., C 11346 Coy, P., C 11661, C 12679 Chan, P. C., A 12123 Cltffton, E. E., C 12773, C 12775, Coyne, N., C 10820 Chaplin, J. P., A 12764 C 12780, C 12781 Corrolino, G., A 11847, F 10818 Chapman, B. L., F 12234, Clostre, F., E 11548 Craddock, V. N., A 11236 F 12415 Coat, P., C 11350 Craig, A. W., A 12585, A 12685 Chapman, R. E., J 12845 Cobb, L. M., A 12656 Craig, R. L., A 12405 Charles, J. L., A 11067 Cockrill, B. L., A 11n79 Cramarossa, L., E 10327 Charms, B. L., E 10457 Codegone, M. L., A 11355, A 12357 Crane, S. C., D 11158 Charpin, J., C 10701 Coffman, J. D., E 10305 Crawford, M. D., B 12348, E 11411 Chassagne, D., C 11539 Coghill, C., B 12658 Crawford, T., E 11411 Chattopadhaya, M. L., C 11979 Cohen, B., A 10826, A 12579, Cremonint, G. P., E 11370, E 11374 Chaudhry, A. P., A 12171 A 12642, A 12684 Crofton, E. C., B 12349 Checcacci, L., 8 10514 Cohen, D. B., E 11695 Crook, A. F., C 12025 Chedd, G., E 11820 Cohen, D. W., C 12152, C 12177 Crotty, J. J., A 11256 Chen, T. T., A 11068 Cohen, J., B 11916 Crout, D. W., A 11291 Chernisck, R., D 12092 Cohen, S. B., K 11140 Crowd', J. P., J 11993 Chernyoheva, N. 1., D 10817 Cohn, K. E., E 12062 Crowe, M. W.. A 12763 Cherry, C. P., A 11018, A 12580, Colalongo, C., E 11374 Croxatto, 0. C., D 11525 A 12581, A 12582, A 12669, Colberg, K., E 11927 Cudina, 8., A 11050 A 12670 Cole, F. H., C 11405 Cugell, D. W., 0 10348

311 316- Cullen, K. J., D 11294, E 115W Dean, C., B 11492, B 12308 Devys, M., A 11961 Culver, D. H., J 11419 Deane, R. F., A 12327 De Wijn, J. F., F 11835 Cummings, J. R., A 11803 De Angelis, L., B 11375 De Witt Fox, J., .3 12631 Cumpston, G. N., E 11597 deBoer, L., E 12748 Dhssmana, K. 1!.., A 11662 Cundiff, R. H., A 11658 Dechy, J.-P., A 12453 Dhincisa, D. S., E 11659 Cunningham, J., I 11488 de Genres, E 12041 Diamc1C, M. L., E 10600 Cuparencu, B., A 12396 de Grande', G. 0., C 10699 Diamond, L., A 10338, A 10355 Curnow, D. H., D 11294, E 11597 De Crandis, C., B 11368 Diamond, P. H., D 10482 Curphey, T. J., A 10236 de Groot, M. J. W., B 10485 Diaz, F. V., E 10477 Custovic, F., K 11044 de Haas, J., E 10514 Diaz, J., C 11920 Cwiklicka, A., F 12358 Deichmann, W. B., A 11893 Di Bella, S., A 11535 Czeizel, E., A 11262 Deitel, M., F 11981 Dickens, F., A 12577, A 12620, Dejdar, R., E 12491 A 12661 de Kock, D. H., A 12687 Dickinson, J. I., C 11813 De Lajartre, L., C 11693 Dickson, S., J 11238 Delaunois, A. L., A 11615 Dieckhues, B., E 11949 Delavierre, Ph., C 11459 Diehl, H. 5., J 11317, J 11444, Del Bono, M., E 10426 J 11690 D'AddesCa, C., E 10327 Del Carmen Alvarez, M., A 11902 Dies, R., J 12373 Dadoni, L. C., E 12042 del Castillo, J., A 10392, Dilley, J. W., J 12423 Daftary, D. K., C 11021, A 11902 Dimitrijevic, R., A 11169 C 12170, C 12413, F 12333 D'Elia, J. A., C 12261 Dincuff, P., C 11350 Dahl, S., F 11760 Della Porta, C., A 11924 Dines, J. E., D 11288 Dalderup, L. M., E 10379 Delmer, D. P., A 12593 Dint, W., A 11461 Dale, E., A 11489 De Luca, F., E 10327 D'Intino, S., E 11542 Dale, M. M., A 12426 De Lucas, A. C., J 12644 DiPaolo, J. A., A 11289, A 12160, Dalessio, D. J., A 10363 Delwaide, P., A 11943, (see A 12483 Dalhamn, T., A 10838, A 10871, also Delwaide, P. A.) Dipple, A., A 12562, A 12564, A 12114, D 10221, J 10240 Delwaide, P. A., A 11938, (see A 12637 Dalitsch, W. W., C 12268 also Delwaide, P.) Dixit, K. S., A 11662 Dall'Oglio, D., C 11279 Dembinski, J. R., F 12479 Dixon, M. F., D 11141 Dalrymple-Smith, D., J 11622 Demin, A., A 11169, A 11188, Djordjevic, B. S., E 12185 Dalzell-Ward, A. J., J 10761, A 11190 Djordjevic, V., D 12132 J 10806 De Muylder, Ch., C 14513 Dlin, B. M., E 10680 Damaske, E., F 10855 Denham, R. M., E 10542 Do Amaral Rocha, A., C 11594 Damon, A., B 12164, E 11506 Denk, R., C 11860 Dodo, H., C 10693, C 12416 Damon, S. T., E 11506 Denk, W., B 10623, B 10624 Doe, W., F 11222 Dandiya, P. C., A 11003 Dennis, M. W., A 10781 Doerker., H., D 10214 D'Anelli, A., D 10695 Densen, P. M., D 12406 Doll, R., B 11334, 3 11523, Daniel, E. E., A 10429 Denton, R., D 12090 C 10273, E 11561, E 11883, Daniels, A. C., C 11906 Department of National Health and E 12650, J 11237, J 12176 Denise, K., F 12465 Welfare, Canada, A 12443, Dominici, G., A 11847 Dao, T. L., A 10335, A 11897 B 12536, J 12444 Dominici, L. M., B 11746 Dappen, C., D 10803 de Paula, A., C 10438 Domino, E. F., A 10378, A 10499, Dart, C., D 11157 de Petra, V., 0 12325 A 10957, A 11550, A 11896, Datta, S. P., B 11449 Depierre, A., C 12130 A 12702 Davidson, A., A 12492 Depoer, R., D 12503, E 11738, Doers, S. E. D 11409 Davidson, J. M., D 10891 E 11856 Donald, M. N., I 11384 Davies, A. J. S., A 12571, De Pompeis, C., D 10326 Donaldson, A. W., C 11632 A 12654 Derntl, F., E 11250 Done, A., A 12401 Davies, C. T. M., F 11783 Desai, 3. R., B 12753 Donner, M. W., D 12168 Davies, R. D., C 12016 de Santi, P. P., A 10609 Donnet, V., A 10609 Davies, R. F., A 11736 De Schaepdryver, A. F., A 11615 Donovan, P., A 11289, (see Davis, A. L., D 10720 De Schepper, P. 3., A 11843 also Donovan, P. J.) Davis, 11. J., A 11500 Deshpande, V. A., B 11017 Donovan, P. J., A 12160, A 12483, Davydov, Ys. S., A 12818, de Soto-Wartgrink, H. K., E 10514 (see also Donovan, P.) E 11831 deIreville, R. T. P., A 11110, Dontemalfr: W., A 10754, A IF-9, Dawber, T. R., E 10922, D 10589, D 11105, (see also A 11005, A 11037, A 11866, E 11778, E 11828 derev111e, T. P.) F 11040 Dawes, J. D. K., C 11603 T. P., D 10787, (see Dote, J.-F., A 11220 Dawson, D. A., A 11020 also deTreville, R. T. P.) Dotte, W. H., C 12648, C 12649 Day, T. D., A 11786 Deutscher, S., E 11596 Douglas, A. S., E 11094 Dayman, H., D 12099 de Villiers, A. J., B 11480 Douglas, J. 5., A 10781 Dayton, S., E 11816 Devine, K. D., C 10710 Doyle, J. L., J 12718 de Almeida, A. R. E., D10705 De Vries, N. C.I., C 11509 Doyle, 3. T., E 10217, E 12246, E 12290, E 12552

312 3/4 Dragstedt, L. R., F 11098, Efroimson, V. P., C 12706 Fabbri, M., D 11839 F 12009' Eggen, D. A., E 10770, E 12145 Faber, L. P., C 10683 Dren, A. T., A 10499 Ehrlich. R., D 10505, D 10506 Fabro, S., A 11660 Dreve, C.-J., A 11264 Ehrner-Samuel, H., A 12020 Facchini, C., E 11370, E 11374 Drnkova, V., B 11450 Eichel, B., A 12633 Fackler, V. A., D 10554, 3 10497 Drogendijk, A. C., C 11838, Eisenberg, H., B 10465 Facnnet, J., E 11830 C 12226 Eitner, S., E 10944 Pagan, E. L., J 12716 Drombian, Y. C., E 10422 Sirup, B. E. V., K 12841 Fahy, A., C 12240 Drozdzeveka, 2., B 10415, El-Attar, A. A., B 12157 Falk, H. L., A 12698 B 11155 El Maui, M. A., D 10247 Falor, W. H., C 11669 Druckrey, H., A 10758, A 12306 Eldridge, F. E., E 12062 Familiar, R. C., F 11911 Druts, H. P., F 10679 Eliot, R. S., E 11441 Fan, It.-8., B 11909 Dubitsky, M., A 10584, C 10663, Elliott, A., D 10724 hinge, R., A 12331 K 10529, K 11696, K 12036 Elliott, R., E 10248 Farago, I., K 10525 Dubose, T. D., Jr., F 10498 Elmenhoret, H., A 11005, A 11206, Fano, 0. M., C 10524 Duhrow, L., J 11296 A 11285, A 11955, A 12052, Farber, D., A 11948 Dubrulle, P., E 12038 F 11040 Fardy, A., A 11176 Duchosal, F., E 11546 Elmer, I., A 12023 Farina, V., J 11577 Ducloux, C., E 12044 Elmes, P. r2., B 12588, 11 12680 Yarpour, A., C 12782 Dudley, E. F., C 11976 El-Sevefy, A. Z., D 12321 Farr, L. E., J 12718 Duflot, J. C., A 1U609 El-Sherif, A. A., E. 10729 Fasulo, V., J 12126, J 12127 Duggan, J. M., P 12234, F 12415 Elsom, K. 0., B 11792 Fattal, G. A., D 12092 Duke, C. A., C 10605, C 12730 Elson, L. A., A 12568, A 12682 Paves, C., C 11968 Dulan, L. A., A 11207, A 11203 Elwerdin, J. M., C 11964 Favilli, R., A 11166 du Meenil da Rochamont, V., Emirgil, C., D 12275 Federal Trade Commission, A 12368 A 12534 Emmanuel, G. E., D 12070 Fedrissi, L., A 11174 Dumoulin, F. V. B., C 12226 Emmelot, P., A 11837, A 121E4 Feinleib, M., E 12142, E 12544 Duncan, C. H., E 11401 Enet, R., B 11547 Feldman, H., A 12472 Dunger, M., A 11204, A 12045 Engel, R. R., E 10568 Fellingham, S. A., J 11237 Dunham, L. J., C 10346 Engelberg, H., A 10259 Felton, J. S., E 10484 Dunn, D. P., J 10407 Engelberg, L. P., A 10259 Fed -Pearce, D., F 12465 Dunn, J. E., Jr., C 11566 Engle, C. C., A 11885 Ferber, K. H., C 1210 Dunnill, M. S., E 12082 Enticknep, J. B., E 12345 Ferguson, T. B., B 10999, C 10692 Dunphy, E. B., F 12286 Environmental Health and Safety Fernan-Zegarra P, L. A., B 11864 Dunvoody, J., I 12139 Research Associates, A 10580 Fernandes, C., A 12011 Duong, P.-N.. C 11947 Epic!, M. S., E 10262 Fernstrom, R., C 11053 Du Plesels, L. S., C 11789 Epstein, Y. H., E 11596, E 11793, Perrando Cucarella, J., F 12603 Durand, J., C 10467 E 12247 Ferrante, C., E 11278 Duranti, C., F 10317 Epstein, H. H., D 10482 Ferranti, C., C 11279 Durst, A., A 12488 Epstein, M., E 11695, (see also Ferreira, I. 3., E 11355 Meek, J., E 11954 Epstein, M. B.) Ferri, E. S., A 12474 Dvorak, L., B 12133 Epstein, M. B., E 10783, E 12748, Ferris, 1. C., 8 11877, (see Dvorakova, M., 11 12133 (seealso Epstein, M.) also Ferris, B. C., Jr.) Dymicky, M., A 10937 EpareinT7F: S., A 10572, A 12495 Ferris, B. C., Jr., D 11341, (see Dsyubko. N. Si., A 12193 Epstein, S. V., D 11109, D 11251 also Ferris, 8. C.) Frkstam, C., D 10794 Yerrucci, H., E 10322 Ersleben, E., A 12053 Plaid:Ivan, B. S., A 10469 Esher, H. J., A 11881 Mange, F., E 10514 Ullman, W. B., C 10208 Fiegel, C., E 12455 Esteban, L., 8 10477 Filley, G. F., D 12059 Estefan, R. M., A 10281 R., D 11365 Earle, R. H., D 10762, D 12100 Estok, S., 11 12511 Fioberg, L., J 12718 Esstcott, H. H. C., E 10642 Easter, T., E 11945 Fine, B. J., F 10511 Echt, R., D 12073 Etienne, J., A 11371, (see Fine, S. L., 3 10244 Ecksrling, B., F 12304 also Etienne, J.-P.) Piogerland, A., 1 12214 Edelman, E., C 10925 Etienne, J.-P., C 11459, (see Finkelstein, N., D 10482 Edelman, N. H., D 12064 also Etienne, J.) Finklea, J. P., D 12691 Eder, M., A 11733 Evans, K., 3 11326 Finley, T. N., D 11446 Edfors, M.-L., A 11059 Evans, I. A., B 10601 Finn, F., 8 12550 Edmands, R. E., E 11559 Evans, M. D. 8., B 11022 Timmer, M., A 10377 Edmonds, J. H., E 12254 Evans, M. J., D 12056 Float, C., A 12824 Edrevs, A., A 11181 Evans, R. R., C 10664, Fiore, J. V., A 11191 Eduard, V. D., A 11552 C 10665, J 10678 Fisch, C., 11 11559 Edvards, J. A., J 12611 Evans, S. H., J 11622 Fischetti, M., D 11942 Edwards, K., A 12586 Eysenck, H. J., A 12326, Fischman, S. L., F 12334 Edwards, M. J., E 11659 C 10302 Fisher, G. R., 11 10289

313 3/9 Fisher, R., B 12117 Freeman, C., 0 11158 Cargos, J. L., A 12613 Fisher, V., D 10776 Freeman, H. E., C 10669 1/41arkavi, L. Kh., A 10706 Fishlock, D. J., A 12305 Freeman, W. J., A.11227 Garret, M., A 12761 Fishlock, J. D., A 12545 Frei, J. V., A 10397 Garrett, J. K. F 10498 Fishman, A. P., D 12064 Freiman, A. I., C 12772 Garrison, G. E., E 12029 Pieter, T., C 12808 rude, E. D., E 11814 Garrison, R. J., E 12544 Fits-Gerald, J. M. E 12276 Frejaville, J.-P,, A 11270, Garza Carta, R. A., C 12194 Fitsgerald, P., E 11241 F 11540 Guam, A. L., A 10490 Fjelde, A., A 10488 Freour, P., D 12037 Csasner, E., A 12335 Flake, A., A 10862', A 12619, Friberg, L., A 11052, B 11299, Cates, A. H., A 10531 A 12673 E 11042 Caudet, F. J., J 10911 Flanders, L. E., 1II., A 11291 Friedell, G. H., A 11339, C 10560, Gaultier, H. F 11540 Flavlan, N., A 10474, A 10544 C 11890 Cause, E. M., A 10281 Fleischhacker, M., A 11050 Friedman, P. J., E U'060 Gauthier, P., A 12392 Flesher, J. W., A 10633 Friedmann, I., C 11908 Gayvoronskiy, A. P., D 11470 Fleehler, B., A 11082, A 12121 Friedrich-Freksa, H., A 11756, Gazave, J.-24., A 12453 Fletcher, C., J 12176, (see A 11934, A 12178 Gazioglu, K., D 10969 also Fletcher, C. M.) Frisch, P., E 11859 Cebber, G. L., A 10373, A 10976, Fletcher, C. M., D 10381, Frischauf, H., A 11768 A 12182 D 10722, D 11109, D 12030, Fristedt, B., A 12020 Gebel, P. P., A 10638 (see also Fletcher, C.) Frith, C. D., A 10586 Geiser, B., D 11848 Fletcher, R. D., A 11780 Frits, J. W., D 10597, (see also Geisler, L., D 12216 Fletcher, W. S., A 12478 Frits, W.) Gelband, S., J 11342 Flick, A. J., J 10565 Fria, W., A 11472, (see also Gelbain, H. 17., A 10255, A 10359, Fodor, J. T., E 10612 Frits, J. W.) A 11612, A 12372, F 12486 Foley, W. J., J 11419 Frost, D. V. C 11246 Geller, A. J., E 10998 Fontaine-Brouty-Boye, D., Fruhmann, C. D 11038 Cellin, G. A., C 11508 A 12312 Fry, D. L., D 12071 Gent, C., E 11153 Fonts, E. A., C 10371 Fuchs, C., D 11038 George, R., D 11347 Foote, E., 1 11333 Fuenning, S. I., J 12843 George, T. W., A 10237 Foraker, A. C., D 10719 Fujimoto, K., A 12727 Ceram!, S., C 11405, E 12526 Forbes, W. I., A 10230, Fukuds, T., C 11267 Gerber, C. J., E 11620 A 10933, B 12175 Fukushima, H., E 11417 Gerlach, H. A., B 11728 Forehand, J. B., A 11063 Fullmer, C. D., C 10256, C 12260, Gershon-Choen, J., E 10888 Formica, C., F 10317 C 12729, D 11481 Gertler, M. H. E 10570 Foreman, W. C., D 12090 Furiosi, N. J., D 11158 Cerwel, T., D 10735 Forster, C., E 12192 Furlaneto, J. A., D 10719 Ceve, J., A 10952, A 10953, Fort, L., C 11731 A 11204 Fortis, P. A., E 11537 Cey, C., F 12220 Fortuine, R., C 10646 Chadiaay, F. N., A 12674 Fosssti, C., C 11747 Chaffer, M. A., E 12742 Foulds, W. S., F 11822, F 12419 Charib, Cl., C 10467 Fournier, E., F 11540 Cheat, C. A 11282, A 11284, Fowler, W. S., D 12689 Gebridge, M. C.A 10907 D 12026 Fox, H. W., A 10488 Gabriel, C. E., C 10914 Cheat, I., C 10698 For, S. M., E 10991 Cadomaka, H., B 10415, B 11151 Chittino, P., A 12355 Fox, W., E 11314, (see also Gaillard, A., C 12452, F 12448 Giammona, S. T., J 12422 Fox, W. B.) Caftan, E., A12734 Ciannelli S., Jr., E 11154 Fox, W. B., A 12130, (see also Calera, H., C 10626 Ciao, N.-B., A 11937, A 12601 Fox, W.) Calibina, A. I., D 11851 Gibson, R. W., E 10262 Frahm, 3., A 11736 Clay, P., A 10550 Giedoss, B., B 11043 Francheschi, C., A 12824 Candevis, 8., D 10615 Cieseke, J. A., A 10225 Frank, C. W., E 11382 Gans, H., F 12158 Gifford, H. W., Jr., E 10301 Frank, N. R., A 12089 CaAtt, R. C., C 12416 Gifford, J. H., B 10557 Frankel, E., E 11088 Carbarech, C., E 12271, E 12332 Gifford, R. W., Jr., E 10108 Frankenhaeuser, N., A 10583 Carbini, G. C., E 11370, E 11374 Gilbert Youth Services, Inc., Frankus, E., A 11614 Garcesu, R., J 12624 J 10388 Frantz, I. D., E 11812 Garcia, E.7 ,C 11966 Cabertsen, V. A., C 11588 France, J., K 10414 Garcia, R 1 11697 Giles, J. A., A 11658 Frasca, J. H. A 10292, A 11229 Garcia Echeverria, J. P., A 12520 Gagel A., D 10189 Fraumani, J. F., Jr., C 11903 Garcia-Ssins, M., B 12607 Gillespie, D. C., D 11281 Freckman, H. A., C 12292 Gardier, R. W., A 10374, A 10423 Gillies, H. F 10654, (see also Frederiksen, H., E 11679, E 12149 Gardner, M. J., B 12348, E 11825 Galles, M. A.) Fredga, A., F 11445 Garfinkel, L., D 10220, E 11654 Ganes, N. A., F 12179, (see Fredrickson, D. T., J 11336, Carg, M., A 11556, C 11348, also Galles, N.) K 10552, K 10869, K 12249, C 11555, C 12609 K 12471

314 314 Cillmann, H., E 11927 Core, I., A 12155 Cruenstein, M., 1 10928, A 11134, Gilman, A., A 12704 Gorrod, J. W., A 12566 A 11139, A 12109, A 12469 Gilson, J. C., B 11511, B 11877, Gorski, R. A., A 12464 Grugan, J., F 11678 12015 Gorski, T., A 12490, A 126% Cruntzig, A., D 12503, E 10204, Gimmy, J., A 11733 Gossner, W., A 11756, A 119% E 11738, E 11856 Cinzel, K. H., A 10436 Goswami, B. H., P 11563 Grzybowski, S., C 11661 Gioffre, P. A., E 11542 Lathe, C.-J., A 12020 2sell, 0., B 10844, B 11273, Giovanelli, E., E 10319 Lathe, K., A 12020 C 10850, E 10845, E 1260U Cfrond, J., J 10622 Guthman, B., E 11054 Guarneri, J. J., D 12077 Gitlin, D., A 11975 Gothoekar, S. V., A 12011 Guberan, E., D 11624 Clashoff, E., E 11813 Gottlob, R., E 11120 Gudima, 0. S., A 12555 Glass, L. H., E 10612 Gottstein, U., E 12043 Guerin, M., A 11905 Glassford, R. C., E 12485 Cough, J., D 12525 Guilford, J. S., J 10675 Clauaer, E. H., D 12293 Could, A. H., J 11993 Guillerm, R., A 10323, A 10474 Clauser, S. C., D 12293 Goyal, P., D 12275 Gulmberteau, J.-C., E /1511 Glazier, J. 8., D 12063 Graf, P. D., D 12074 Culotta, G. J., E 10797 Glazunov, I., E 10514, (see Greaam, J. G., A 11137 Gummer, J. W. P., A 11149 also Clazunov, I. S.) Gramignani, V., I 11845 Gupta, P. C., C 11021, C 12170, Glazunov, I. S., E 10422, Grandjean, E., D 10189 C 12413 (see also Glazunov, I.) Grant, C. Y., J 10282 Gupta, S., B 11449, C 12002 Gleich, G. J., F 12420 Grant, G. A., A 11606, A 12022, Gupta, T. C., D 11306 Gleiniger, J., F 11572 A 12257, A 12572 Gurley, J., C 10501 Click, M., D 12543 Grant, M., K 11810 Guthrie, F. E., A 10950 Clover, E. L., A 11809 Grant, R. L., J 10666 Gutierrez-Colomer, L., J 10736 Gluckman, J.-C., D 11857 Grassi, V., F 10317 Gutmann, H. R., A 11891 Cluckamann, A., A 11018, Crataddur, C., E 11830 Gutowski, F., C 12788 A 12580, A 12581, A 12582, Gray, D., E 12748 A 12669, A 12670 Cray, N., J 11380 Cooke, T. M., D 10593, D 10596 Graziano, J. 1.0 E 10906 Codber, G. E., J 11325 Greco, S., C 11279 Coeritler, K., A 11024 Green, B., A 12535 Goertz, E., A 11955 Green, D. E., J 10571, J 10602 Gofman, J. W., C 10772 Green, G. M., A 11465, D 10752 Haas, H., B 12236 Colbey, R. B., C 12779 Green, J., C 12404 Hackney, J. D., D 12056 Cold, z. H., F 10361 Green, M., A 12546 Haddon, W., Jr., F 11697 Golden, A. S., B 11426 Green, R. L., F 12163 Haddov, A., A 12570, A 12640, Goldenberg, H., A 11139 Greenberg, D., E 10643, (see also A 12641 Goldenberg, I. S., J 12516 Greenberg, L. D.) Hadley, H. C., C 10345 Goldenberg, M. H., A 10489, Greenberg, L. D., E 11921, (see Haenszel, W., B 11017, C 11600 A 10657, A 12615 also Greenberg, D.) Hage, F. C., C 11838 Goldfarb, T. L., C 10632 Greenblatt, M., D 10867 Hagopian, M., A 11015, A 11422 Coldschlager, N., E 11250 Creenlav, R. H., C 10371 Hahn, P., E 11035 Goldschmidt, B. M., A 10228, Greenspan, K., E 11559 Hahn, U., E 12205 A 12122 Greenwald, P., I 11623 Haidenkrug, Y., 8 11547 Goldsmith, J. R., E 11657, Gregg, I., D 10721, D 11878 Hairston, P., C 12428 F 10517 Gregor, 0., B 11450, F 11512 Hekama, M., C 11694 Goldstein, D. N., 1 12116, Gregory, J. J., E 11154 Heiden, W. K., E 12172 J 10920 Gresham, G. A., E 12144 Hale, G. S., D 11301 Goldstein, J. C., C 11090 Greaser, I., A 12012 HelevI, H. S., 8 12346 Golod, M. I., C 10208 Greve, D., C 11860 Halfpnny, P. F., A 12731 Caleb, G. R., C 10983 Grieve, J. M., C 12678 Halhuber, H. J., E 11765 Colibtsov, F. S., C 10195 Griffith, R. B., A 10372 Halil, T., D 10724 Gommi, B. W., A 10377 Grimaldi, K. E., J 11681, K 12389 Hall, C., F 11222, (see also Gonzalez, I. E., E 11921 Grinspan, D., C 11920 Hall, G. H.) Cood, C. A., C 10424 Grob, K., A 10234 Hall, G. H., A 10558, A 11486, Good, R. A., A 10441, A 12297, Groover, M. E.. Jr., E 12147 A 12113, (see also Hall, C.) A 12385 Gros, J.-C., C 11355 Hall, Y., E 10783, E 11695 Goodall, C. H., A 11073 Gross, E. G., A 10966 Hallivell, J. V., A 12739 Gooding, P. C., E 12145 Gross, P., A 11130, D 10595, Halloran, J., J 10788 Goodman, E. 8., A 11613 D 10607, D 10787, D 11105 Halonen, M., A 10367 Goodman, L., A 12704 Grossovica, N., A 11076 Halstead, C. L., F 1091e Goodner, J. .., C 11391, Groupe, V., A 11885 Halter, H. M., A 10226 C 12783, C 12787 Grover, P. L., A 12565, A 12636 Hamann, W., F 11467 Goodyear, J. M., C 12S48 Grover, R. F., E 12061 Hamburg, M. V., J 10265 Gordon, 2., J 11329 Hamel, C. G., E 12475 Gordon, M., C 11669 Hamill, W., A 12183

315 3/9 Hamilton, T., A 10447 Hedenberg, I., F 11046 Hinds, J. R., C 10917 Hammond, E. C., 8 10211, Hedrick, J. L., H 10503 Hingerty, D. J., E 12344 11 10249, B 12377, 11 12551, Hee, J., A 10474 Hine, B. F., D 10277 C 12295, D 10220, E 10526, Heidelberger, C., A 10487, A 11068 Hirabayashi, M., A 12798 E 11654 Heilbrunn, A., B 11515 Hirata, Y., A 10031 Hancock, E. W., F 12062 Heinemann, A. L., E 10944 Hirayara, M., C 11009 Hancock, J. C., A 11882 Heinisch, P., A 12811 Hirayara, T., C 10419 Benham, I. W. F., C 12668 Heinrichs, E. H., D 10277 Hirabrunfter, R., A 11212 Hanks, C. T., A 12171 Held, K., E 12510 Hitchcoci, G. C., C 10917 Hanninen, 0., A 10260 Helin, P., E 12271, E 12332 Hitter, H., A 11177 Hanaluwka, H., B 10623, B 10624 Hellman, S., C 11791 Hitosugi, M., C 11894 Hansotia, P., F 11311 Hellstrom, P.-A., A 10614 Hlavovs, A., E 12491 Monsoon, E., A 11148 Hellung-Larsen, P., E 10603 Hloueal, L., E 11954 11.!, 1. U., A 12740 Heneage, E., A 11486 Hoang, D.-D., C 11947 Wade, T., C 10309 Hennessy, E., B 10973 Hochbaum, C. M., J 12705 Harboyan, G., C 12311 Hennig, W., A 12052 Hock, L. E., J 11330 Harding, H. B., D 10717 Henning, S., A 11758 Hoff, H. F., E 11120 Hardy, D. R., J 10674 Hennings, H., A 10934, A 12484 Hoffmann, D., A 10207, A 10227, Harewood, J., B 11234 Henriksen, A., A 12047 A 10353, A 10585, A 10908, Harington, J. S., C 11818 Henry, J. P., F 12312 A 10949, A 11589, A 11663, liarkavy, J., E 12445 Henry, M. C., D 10505, D 10506 A 11723, A 12124, C 11389, Harks, H.-P., A 11005, A 11037, Henschke, U. K., C 12778 J 10111 A 11264, A 11285, A 11736, Hepper, N. G., D 12689, F 12420, Hoffmann, H., E 11414, (see also A 11866, F 11040 (see also Hepper, N. G. G.) Hoffmann, H. L.) Harkness, D. G., C 11603 Hepper, N. G. G., D 12320, (see Hoffmann, H. L., 0 10734, (see Harley, J. L., 8 12658 also Hepper, N. G.) also Hoffmann, H.) Harley, R. A., E 12060 Herberg, D., D 11590 Hoffmann, M., A 12178 Harlow, E. S., A 10372 Herdly, J., C 10541 Hoffmann, P, C A 11066 Harnea, J. R., E 11316 Herles, F., D 10801 Hoffstaedt, E. G. W., J 11609 Harnett, A. L.. J 10764 Hermann, R. S., A 11741 Hogg, J. C., A 12089, D 12098 Hero, M. S., J 12004, J 12423 Hertel, M. B., E 10888 Holaday, D. A., 11 11586, C 11585 Harpending, N. C., E 71506 Herms, G., F 11572 Holbaek-Hanssen, L., J 10948 Harris, R. J. C., A 10428 Hernandez, L. J., C 11966 Holgye, Z., A 11739 Harrison, C. V., E 11379 Herold, H. J., B 10927 Holland, H. C., A 11556 Harrison, D. F. N., C 11989, Herrlich, H. C., A 10374 Holland, W. W., B 12530, 0 10724, F 10894 Herron, H. R., I 10660 O 10851, D 11293 Harrison, T. R., D 11729 Herz, A., A 10835 Hollwich, F., F 10856 Harrison, Y. E., A 10377 Herzog, H., D 12078 Holma, B., A 10614, D 10452 Hart, L. M., A 10638 Hess. H., E 10848, E 11867 Holmes, E. C., A 10684 Hart Hansen, J. P., E 10824 Heyden, S., IS 11836, C 11573, Holmes, F. F., B 10988 Hertel, G., C 12033 E 11620, E 12110 Holmes, S., C 10273 Hartley, L. H., 8 12061 Heyman, A., E 12110 Holter, F. J., J 10530 Hartman, B. J., K 11666 Hiasa, Y., A 11530, A 12166, Rani/inn, H., C 11860 Hartmann, G., E 11546 A 12287, A 12363 Homburger, F., A 10239, A 10534, Hartroft, W. S., E 11457 Hickey, N., E 10306, E 11639, A 11978, J 10240 Harvey, R. G., A 10367 E 12282, E 12550, (see Homma, H., C 11267 Harvey, W. R., A 10445 also Hickey, N. J.) Honda, T., E 10198 Hashimoto, K., A 10331, A 10967 Hickey, N. J., E 12344, (see Honda, Y., A 12010 Hatfield, G. M., A 12314 alo Hickey, N.) Honeyman, M., J 12373 Hathaway, B. M., C 10501 Hickl, E.-J., F 10854 Hood, B., E 11634 Hattori, J., D 11538 Hien, D.-P., A 10194 Hood, L. V. S., A 10987 Hauffe, Sh., E 12219 Hieu, H.-T., A 10196 Hoon, J. R., F 10493 Houghton, G., A 11995 Higgins, G. A., B 11515 Hoopes, J. E., C 10773 Hauserman, M., A 11212 Higgins, I. T. T., B 11877, D 10592, Hopewell, J. W., A 12667 /leveler, M., E 11732 E 12343 Hoppe, R., C 11727 Hauss, W. H., 8 10707, E 11743 Higgins, M. W., B 11877, E 12343 Horacek, F., D 1001 Havlik, R. J., B 12544 Higginson, J., C 11126 Horacek, J., C 11041 Haworth, J. C., F 11898 Higuchi, K., A 10765 Horak, J., C 11272 Hayashi, I., A 11530, A 12363 Hilarfs, S. S., C 12777, C 12778 Horino, M., C 10419 Hayes, J. A., D 12489 Hilt, R., A 11139 Horn, D., G 1101, J 10215, Hayes, R. L., C 10889 Hill, A. B., J 11324 J 10571, J 10602. J 10673, Hagan, E., E 12041 Hill, C. R., A 12659 J 10676, J 11319, J 11320, Hazard, R., A 10547 Hill, I. D., C 10273, D 10722 J 11328, J 11565, J 11637, Head, J., C 10763 Hill, I. G. W., B 12736 J 12498 Healey, P., D 12253 Hill, J. L., D 10597 Horn, K., C 12648, C 12649 Heath, K., 8 11234 Hines, K. H., G 12714 Hornberger, H. R., C 11108 Hecker, E., A 10455 Hinder, R. A., C 11912 Horner, D. W., D 11992 Hedberg, E., E 12223

316 3 ko Horowitz, H. L., A 11339 Indul'aki, Ta., B 11940 Jellinck, P. H., A 11452 Horatmann, P., E 10514 Ingram, D. J. E. A 12427 Jenkins, C. D., E 10261 Horton, R. J. M., J 12718 Insull, W., Jr., E 11923 Jenkins, R. W Jr., A 10728 Horvath, E., A 11601 Inui, N., A 10398 Jenks, R. K 11696 Houlen, A. C 11694 loan, E., A 11165 Jensen, D., E 12190 House of Commons of Canada Soli, A., J 11036, J 11577 Jenson, C. B., C 11456 28th Parliament, 1st Session. Ionescu, H., C 12129 Jensovsky, J., D 12805 I 11700, I 11701, 1 11702, Ipatn, J., B 11792 Jepsen, 0., C 11008 I 11703, I 11704, 1 11705, Irish, F. W., A 11232 Jirasek, V., F 11512 I 1136, I 11707, 1 11708, Irish, R. A., J 12425 Jodl, R., A 12050, A 12051 I 11709, I 11710, 1 11717., Irlin, I. S. A 11027 Johnson, B. C., C 11976 I 11712, I 11713, 1 11714, Ishida, A., A 10362, A 11476, Johnson, D. E., A 10229 I 11715, I 11716, 1 11717, A 11479 Johnson, J. H. G 11340 I 11718, I 11719, I 11720, Ishigawa, S. E 10198 Johnson, K. G. C 10404 I 11721, 1 11722, Ishii, K., C 10188 Johnson, P. C. A 10423 House of Commons of Canada Ichikawa, K. A 12439 Johnson, S., A 10630 28th Parliament, 2nd Session, Ichikawa, S. C 10410, D 10776, Johnson, W. E., A 11173, A 11185 I 12836 D 12092 Johnson, W. R., A 11209 Houtsmmller, U. H. T. . 12403 Ishimori, A. A 10411 Johst, E. C 10628 Howard, A. N., E 12144 Israel-Asselain, R., D 11840 Joinville, R., C 11693 Howard, P., D 10753, D 12018 Issa, P., C 11539 Jones. D. G., C 10914 Howell, H. L., E 12485 Itil, T. M., F 11490 Jones. D. W., A 12424 Howland. W. S., C 12774 Itkin, I. H. D 12087 Jones, E. W., D 12406 Hozund, H., A 11491 Ito, K., D 11538 Jones, F. A., C 12533 Hrubec, Z., B 11299 Ito, N., A 11530, A 12166, Jones, R., A 12568 Hrycak, T., A 12028 A 12287, A 12363 Jones. W. L., A 10778 Hsi, B. P., E 11923 Ivankovic, S., A 10758, A 12306 Jordan, J. W., C 12017 Hsu, C.-J., E 11381 Ivanov, N., A 10875, A 11187 Jordan, P. H., Jr.. F 10275 Huand, T.-S., E 11381 Ivanova, I. S., D 11470 Josipovic, V., E 12185 Huber, A., F 11926 Iwakura, M., D 11538 Jost. F. J 10842 Huber, F. B., C 12128 Iwanaga, y., A 12155 Jotti, D., D 11274 Hudakova, G., 8 12511 'card. C. A 11905, A 11973 Jouve, A., E 11354, E 11773, Hudson, R. P., J 11551 Izquierdo, I., G 11607 E 12039 Huggins, C., A 10926, A 11811 Jovanovic, A., J 12215 Hughes, J. M. B. D 12063 Jovanovic, M., E 12185 Hugli, W. C., Jr., J 10911 Joyce, R. S., A 11200 Huisinga, E., C 10702 Jozsa, S., D 11268 Hull, E. W., k 11975 Juchau, M. R., A 12300 Hundley, J. H. J 12628 Julich, H., D 11849 Hunt, V. R., A 11723, D 11682 Jablanov, Lj., D 12132 Jull, J. W.A 11914, A 11985 Huong, B.-Q., C 11947 Jacin, H. A 11191 Junemann, G., F 10856 Hurst, L., A 12601 Jackman, R. J., C 10424 Junge-Hulaing, G., E 10707, Hussein, H., D 10247 Jackson, H., A 12586 E 11743, E 12213 Huth, T., C 11083 Jackson, J. A., F 10573, F 10574 Jussawalla, D. J., B 11017, Hwang, S. H., D 12090 Jackson, J. E., F 10498 C 12003 Hyams, L., E 12289 Jacobs, P. D 11404 Just, J., A 12376 Hyatt, R. E., D 12689 Jacobsen, 0. S., J 11332 Jacotot, B., A 11770 Jacquin, H. A 10609 Jaffe, W. G., A 10912 Jain, S. R. E 10992 James, D. G., F 11222 James, E. A., Jr., A 10423 Kaczala, 0. A., C 11669 Iball, J., A 12643 James, 1. P., J 11802 rade, S., C 11267 Iida, T., A 12335 Jamieson, J. D., A 10292, A 11229 Kaempe, B., A 12456 Ijichi, K., A 10254 Jan, F., A 11770, E 12027 Kahan, B. D., A 10684 Ikeda, R. H. A 11067 Jancik, E., D 10200, D 10942 Rahaner, H., C 11091 Ilievski, V., A 10938 Janisch, W. A 11366 Kahle, P., A 10434 Iljin, G. S., A 11170 Janos, V., E 11945 Kahlke, W. E 11826 Il'yuchanok, R. Tu., A 10808 Jarvik, M. E., G 10632, J 11686 Mandl, F., E 12209 !mat. K., A 10354 Jasinskaja, L. B., A 10202 Kajima. H. A 12256, A 12258, Imaizuml, T., A 12108, A 12156 Jaamin, G., A 11019, A 11460, A 12259 Immich, H., B 10843, B 10844 C 10618 Kajiyama, C., A 12155 Imre, U., C 11925 Javadpour, N. C 11385 Kakita, S., C 10652 Ulla. R. J-,'11 11427 Jedrychowski, W., D 11039 Kalaysky, S., D 11673 Indira, 0. C., B 11449 Jelinek, R., C 11759 Kollichurum, S. E 11413

317 Ss/ Kellner, C., If 10406, C 12204 Kennedy, R. F., I 11322 Klonowski, S., 8 10316 Kalman, E., A 11936 Kent, M., A 11889 Klucsny, R., J 10486 Kaltreider, N., D 10969 Kerbrat, C., C 11350 Knoebel, S. B., E 11559 Kalyuthxyy, R. R., K 10412 Kernels, J. P., C 11693 Knox, J. F., C 10273 Kamenetchikova, S. R., A 11207, Kershbaum, A., A 10777, A 11085, Knox, W. E., A 11339 A 11208 A 12795, A 12798 Koch, A. W., J 10929 Kameura, N., C 12155 Kertes, I., C 12810 Kocsis, S., C 12807 Kamlmurs, N., C 10419 Kessel, H., A 10434 Kodama, M., A 10822, A 12745 Kamlyama, R., C 10419 Kessler, P., C 128)8 Koelsch, K. A., F 11572 Kanakemi, H., C 10410 Ketcham, A., C 12152, (see also Koeppe, R. E., A 12594 Kande, K., C 10419 Ketcham, A. S.) Kofman, J., D 10475 Kande, H., A 10362, A 11476, Ketcham, A. S., C 12177, (see Koga, S., C 10420 A 11477, A 11479 also Ketcham, A.) Kohler, H., D 10829, D 11369 Kandus, J., D 10641 Kettel, L. J., D 10348, D 12487 Kohl!, R. P., A 11662 Kane, G., 0 11673 Keutear, C., K 10382, (see Koike, S., A 12439, E 10198 Kane, K., C 10419 also Keutser, C. S.) Koivuniemi, A., C 1094 Kane, W. C.,E 11408 Keutser, C. S., C 12714, K 10533, Kojima, M., A 10556 Kanee, B., C 10480 K 11412, K 12610, (see also Kolbye, A. C., Jr., D 10520 Kaneko, H.,A10254, A 12699 Keutzer, C.) Koll, M., D 10717 Kaneko, M., C 11056 Keys, A., E 11631 Kollar, L., C 12808 Kennel, W. B., E 10213, E 11506, Ketdi, P., E 12395 Koller, P. C., A 12655 E11781,E1:142, E 12263, Khachaturova, T. S., A 12711 Koller, S., J 12364 E12544 Khairalleh, P., C 10820 Kolmodin, B., A 12020 Kartemlr, I., A 11991 Khayetsky, I. K., A 12468 Kommerell, C., F 10318 Kantor, S., D 10960 Kids, H., C 10439 Komorn, R., C 11633 Kapuatnik, A. Ya., P 11872 Kid:, D. H., A 10543 Konishi, M., A 12439, E 10198 Kareceony, C., B 12809 Kidner, P., E 12726, (see also Konishi, S., F 11451 Karasek, M. A., A 10531 Kidner, P. H.) Kono, M., F 11057 Karnofeky, D. A., C 12779 Kidner, P. H., C 12019, (see Konovalova, N. P., A 11827 Karrer, K., B 10623, B 10624 also Kidner, P.) Konttinen, A., C 12033 Karuga, V. K., C 12035 Kiefer, H., E 11466 Kooyman, 0., D 10329 Karvonen, H. J., E 12244 Kienecker, B., E 11743 Koransky, W., A 11741 Kasap, H. S., D 11293 Kika, K., F 10747 Kornitter, M. D., E 10514 Kaechak, M., A 11130, D 11105 Kilburn, K. H., D 10965, D 11438, Korotkova, G. P., A 11152 Kassau, E., A 12437 D 12076 Korean -Bengtsen, K., E 11634 Kaseir, J. T., E 10286 Kilpatrick, J. J., J 10893 Koschorreck, 8., D 12503, E 11A8, Kastelaa, S., B 10760 Kim, B. M., D 11682 8 11856 Kastl, 0., E 12501 Kimbel, P., D 10805, E 12083 Koss, L. C., C 12104 Kasymkhodzhaev, E. S., F 12819 King, S. H., F 12136 Kostin, J. S., 8 11407 Kato, A., C 11267 Kingsley, W. F., A 10397 Kostina, V. V., D 10817 Kato, R., A 10986 Kinosnits, S., E E 10620 .ossarowski, T., B 10415, 8 11155 Kato, Y., B 10999 Kinzel, V., A 11007 Kotin, P., C 12524 Rats, C., A 10962, A 12122 Kirikae, I., C 10431 Koubs, U., D 11038 Kate, F., D 11364 Kirman, D., D 10220, D 10330 Kovacs, 8., C 12810 Kate, L. N., E 12317 Kirscht, J. P., J 12845 Kovacs, K., A 11601, A 12267 Kaufman, J. J., C 12751 Kissen, D. M., C 12460 Kovtunov, R. S., A 11207, A 11208 Kaufmann, P. C., D 10801 Kissen, M., C 12460 Kowalyshyn, I., D 11337 Kavatis, C., A 11163 Kitamura, H., A 12287 Krachun, S. V., A 11850 Kavetaky, R. E., A 12468 Kitayeva, N. D., D 10817 Kramer, K., B 12117 Kavachi, T., A 10931 Kiviloog, J., D 10794 Kranc, M. F., A 11200 Kawaguchi, Y., C 11009 KJeldsen, K., E 10603, E 10604 Krarup, T., A 10883, A 12112 Kawamura, H., A 11550 Klaiber, M. S., A 11134 Krasnokotskays, E. 8., A 10202 Kay, C. R., B 12723 Klassen, D., C 12025 Krassen, E., C 12842 Kay, K., A 10532 Kleihues, P., A 12306 Krause, F. D., D 11281 Kayaalp, S. 0., A 11804 Klein, E., A 10488 Krekel, L., J 12364 Kazemi, H., D 11231 Klein, K., B 11774, C 10930 Kreuter, F., A 11084 Keehn, R. J., B 11515 Klein, R. C., D 12390 Krewson, C. F., A 10517 Keith, C. H., A 11198 Xleinfeld, M., D 10329, D 10448, Kreyberg, L., C 10380, C 12005 Keller, A. 2., C 12375 (see also Kleinfeld, M. J.) Kriek, E., A 12828 Keller, J. B., E 11596 Kleinfeld, M. J., C 10500, (see Krljgsman-ds tome, W., J 12622 Keller, R., D 12078 also Kleinfeld, M.) Kristensen, E., E 12188 Kellner, C., A 11768 Kleitsch, W. P., C 11984 Krltcheveky, D., I 12143 rally, M. C., A 11975 Kllgerman, M. M., C 11791 Krltsikle, Sp., E 10944 Kelly, R. E., C 12104 Kline, L., E 12185 Kroger, H., A 10434 Keeps, C., K 10413, K 11852 Klingon, G. H., C 12789 Kroller, E., A 11742 Kendig, E. L.. Jr., D 12319 Klintrup, H.-E., C 12435 Kronman, B. S., A 12379, A 12380 Kennedy, J. r., C 10820 Kloese, J., E 1240 Xrstit, S., D 11049

318 3.1,1 Kruegel, D. L., B 12278 Larsen, V., C 12591 Leuchtenberger, C., A 10964 Krueger, G. A. W., E 11929 Lasnitzki, 1., A 12680 Leuchtenberger, R., A 10964 Krull, A., A 11186 Laszlo, V., P 11931 Leutner, R., B 12432 Kcumhols, R. A., D 10738 Latayeva, D. N., A 11207, A 11208 Levander, O. A., A 10961 Krush, A. J., C 10299 Lathrop, J. C., J 1148? Leventhal, H., J 10421 Kruszynski, A. J., A 12047 Latini, P., A 11847 Levij, I. S., A 10640, A 12407, Krut, L. H., E 10656 Laubscher, P., C 10945 A 12488 Krylova, E. A., E 10422 Laughlin, T. J., K 10507 Levin, E., D 10329 Kryea, 1.,E 12225 Laurenzi, G. A., D 12077 Levin, G. S.. A 12506 Kubacki, A., V 12218 Laureano T., E 10603 Levine, R. S., D 11437 Kubickova, Z., F 11513 Launch, R. N., A 11069 Levine, S., J 10658 Kubo, S., D 11907 Laustela, E., C 10994 Levinson, M. J., E 10783 Kucewicz, J., D 12354 Lauweryns, J. M., D 12055 Levitt, E. E., J 12611 Kueppers, F., P 12420 Laval, H. P., C 11969 Levy, J. P., A 12012 Kuhn, H., A 11201 Lavaure, G., E 11354 Lewis, E. A., P 12467 Kuller, L. H., B 12117 Levers, G. C., A 12712 Liang, C. C., A 11416 Kumkumsdzhyan, V. A., A 10469 Lavine, Cl., A 11030, A 11853 Liberman, C., A 11905 Kundur, V. G., D 12390 Lawrence, P. J., A 10905 Librach, G., E 10393 iCunte, H., A 11025 Lawrence, W., Jr., C 12780 Lichtenstein, E., G 12714, Kuntzman, R., A 11065 Lowther, P. J., A 12529, B 12551 J 11681, K 10382, K 10533, Kunz, W., A 11757 Lawton, R., B 11515 K 11412, K 12389, K 12610 Kurihara, T., A 12827 Lazar, P., A 11905 Lichtenstein, N., A 11076 Kurita, Y., A 11071, A 11136, Leach. J. T., A 11064 Lichtlen, P., E 12221 A 12338 Leadbctter, W. F., C 11653 Lieberman Research, Inc., J 10390 Kurohara, S. S., B 10688 Leaver, D. D., A 11240 Liebow, A. A., E 12060 Kvechner, M., E 12283 Leb, G., E 11250 Lifeso, R. H., E 10460 Kutecher, A. H., C 12152, Lebe, V., D 11532 Lijinsky, W., A 10895, A 11917 C 12177 Labovitz, E., D 11428 Likhachev, A. Ye., A 12509, Kuttner, D. H., C 10889 Lebovitz, J. J., D 11428 C 11833 Kuwam, T., E 12531 Lee, A. M., C 11903 Likoff, W., E 10304 Kuzma, J. W., B 11300 Lee, B. C., C 11008 Lillehet, J., C 11588 Maw*, F., A 12798 Lee, B. K., A 11406 Lin, A., C 11608 Lee, C. W., A 10251 Linares N, E., B 11864 Lee, J. H., D 12086 Lincoln, J. E., K 12557 Lee, H,, A 12401 Lindberg, H., E 11695, (see also Lee, P. N., G 10343 Lindberg, H. A.) Leedman, C. L., J 12369 Lindberg, H. A., E 12748, (see Lefemine, A. A., C 10963 also Lindberg, H.) Lacaasagne, A., A 12601 Legator, M. S., A lop Lindberg, J., E 12223 Ladmen, A. J., D 11446 Legg, P. D., A 12764 Lindeman, R. D., 8 12398 La Due, J. S., C 12767 Leeostov, J., D 10470 Lindop, P., A 12663 Ls Figuera, E., E 11355 Legrand, J., V 10433 Lindsay, A. E., E 11443 Lafrenz, U., A 11866 Lehner, N. D. H., E 10959, E 12146 Lindatedt, S., E 11223 Lahtri, V. L., A 11616 Lehnert, G., A 11531 Ltnhart, J., E 12491 Laing, D. H., J 11421 Lehtoauo, E. J., E 12244 Linn, B. S., C 11598 Lake, B., B 11510 Leigh, R., C 12412 Linnell, J. C., A 12532 Lakrita, L., A 12048 Lekaa, H. D., C 10443 Liokis, Th., C 10192 Lal, R. B., E 10206 Lellouch, J., A 11782 Lint, F., D 11570 Lalonde, E. R., A 12421 Lewin, B., K 10528 Lippmann, H., D 10293, D 10977, Lamb, D., D 10598, D 11672 Lemon, F. R., B 11300 D 11494, D 12703 Lanbic, I., E 12185 Lenegre, J., E 12041 Lisa, J. R., B 11425 Land, F., C 12833 Lenard- Jones, J. E., F 12237, Lischntr, H. W., C 12239 Landow, S. A., A 11722, F 10517 F 12264 Litt, 4., D 12090 Lang, D. M., E 12001 Leon, A. S., E 10799 Latlu. C. C., .1 11886 Lang, P. D., E 11923 Leong, J. L., A 10442 Little, J. B., 11723 Lang, R. E., A 11199 Lecvskt, J., J 10427, J 11277 Litainger, E. F., A 11064 Lang, V. 0., E 11855 Le Page, R. N., A 11248 Liu, P. I. S., A 11613 Lang, W. J., A 11080 Lepine, C., D 12539 Lloyd, J. W., B 11586, D 11805 Lange, D., C 11868, F 12210 Lepper, M. H., D 10978, D 11127 Lloyd, T. C., E 12252 Lange, C 11860, J 11846 Le Riche, W. H., B 113)2 Loche, J., A 11164 Langkaap, N. H., A 11780 Le Roux, B. T., C 12125 Lockshin, M. D., E 12343 Langlends, J. H. M., B 12680 Leona, P., A 11353 Lodi, R., C 11745 Langaeth, L., A 10228 Lesca111e, E. B., C 11966 LoevensoA, R. B., F 10916 Langston, H. T., C 11642, Lesko, S. A., A 10617, (see also Lofland, H. B., E 12146, (see also J 10997 Lesko, S. A., Jr.) Lofland, H. B., Jr.) Lansley, T. S., E 12345 Lesko, S. A., Jr., A 11496, (see Lofland, N. B., Jr., E 10959, (see Lanzette, J. T., G 10798 also Lesko, S. A.) also Lof1aue, H. B.)

319 323 Logani, K. B., C 12459 mpdronero, R.. A 10732 Massa, V., D 11675 Logue, B., E 11442 Martian, P. 0., C 11769 Master, A. M., E 10998 Loh, W. P., A 12472 Maempel, J. V. Z., E 12315 Masuda, S., C 11009 Lohrs, U., A 11733 Magee, P. N., A 10245, A 10755, Masuda, Y., A 10353, A 10908 Lombardi, C. IS 11746 A 11240, A 12232, A 12575, Matarazzo, R., C 11526 Lomsadze, B. A., A 10197, A 12576 Mateescu, D., 0 11532 A 12701 Magni, L. A., A 11032 Maternowska, W., D 11039 Long, D. M., D 12096 Magnus, K., C 11694 Matero, A., E 10537 Long, J. P., A 10966, A 12724 Magour, S., A 11741 Hattie, C., A 11220, A 11671 Longefait, H., C 1C701 Magyar, E., E 12462 Mathews, J. D., F 11221 Longhino, C., E 11537 Mahan, C. D., C 12778 Mathieu-Levy, N., A 11034 Loop, A., E 12289 Maier, W., A 10522 Matras, 11., F 11462 Lopez, P. 1., A 12399 Maillard, J.-M., C 11968 Matsumoto, M., C 11267 Lord, C. P., D 10743, D 10969 Mainardi, L., A 11032, A 11033 Matsumoto, S., A 12306 Lorenz, H. W., A 11265 Maino, R., D 12825 Matsumura, S. A 10967 Lorenzen, I., E 12271, E 12332 Maisel, J. C., D 11157 Matsuyama, M., A 11071, A 11249,, Loudon, R. C., D 10751, D 12069 Maitrya, B. B., A 12740 A 11823 Louhija, A., C 12033 Maki, Y., A 10362, A 11476, Mattace-Raso, C., J 11036 Loveless, A., A 11549 A 11478, A 11479 Matthews, D. M., A 12532 Lovestedt, S. A., F 10864 MakovickF, E., B 12511 Matthews, R. S., A 12424 Lowe, C. K. D 10884 Malcolm, A. I., C 11070 Matthiessen, M. E., E 12271, Lucas, C. H. W., F 11427 Malec, A., E 11276 E 12332 Ludwig, A, m., F 11900 Malejkagiganti, D., A 11891 Hatusiewicz, E., A 11171 Lull. U. C., E 12080 Mallard. J. R., A 11889 Matveichvck, Y. D., A 12468 Luganskaya, L. N., A 10202 Mallow, J. E., E 10280 Matzinger, D. F., A 12696, A 12697 Luginbuhl, H., E 11990 Mallows, H. R., J 11448 Matson, C., J 12801 Lukl, P., E 12187 Malmejac, J., E 11548 Maunoury, L., E 10737 Lumens, J. L., D 11127 Malmros, H., E 12480 Maurer, B., E 10306,E 11639, Lundin, F. E., Jr., B 11586 Maloney, J. E., D 12063 (see also Maurer, B. J.) Lundman, T., E 11042 Maltoni, C., A 11282, A 11284, Maurer, 8. J E 12344, (see Luomanen, R. K. 3., C 12775, D 12026 also Maurer, B.) C 12781, C 12791 Mal'tsev, V. M., A 12506 Maurer, M., D 12078 Luthra, U. K., A 11616 Mal'tseva, A. L., D 10817 Mausner, B., C 10672, C 12842 Luttich, W., A 11204 Mammarella, L., U 11942 Mawdealey-Thomas, L. E., D 12253 L'vitsyna, G. M., A 11987 Mancuso, T. F., B 12269, B 12157 May, H., A 12305 Lynch, H. T., C 10299, Mandel, P. R., I 11580, J 12518 Mayer, N., K 12458 C 10389, C 11582 Mann, D., D 11941 Maziarka, S., A 12376 Lynch, S., C 12769 Marinating, C. J., A 10861 Mazumder, M. C., E 12013 Lyon, J. L., J 11418 Mantel, K., A 11948 Mclean, J. B., C 10710 Lyons, H. A., D 12088 Mantel, N., A 10572 McCabe, D. J., J 10709 Marantana, P., C 10695 McCall, M. C., D 11294, E 11597 marcatili. S., E 10426 McClement, J. H., D 10720 Marchegiani, M., A 11360 McCoy, K. E. M., F 12273 Marcheei, N., F 10317 McCurley, D. R., E 10797 Marcone, C., D 10326 McDonald, A., E 11253 Margarit, J., A 11030, A 11853 McDonald, L., E 11253 Hassles, T. J., C 11087 Marinoni, A., E 11766 McFadden, E. R., Jr., D 12088 Hasse. M., B 12541 Marks, C. S., A 10429 McFarland, C. R., D 10717 Macarol, Y., E 12185 Markush, R. E., B 11133 McFarland, J. W., J 12844 Macbeth, R., C 10733 Marriott, H. J. L., E 11432 McFarlane, R.. E 12282 MacComb, W. S., C 11775 Marsh, H. F., C 10299 McGinn. M. E., J 11419 MacDonald, A. D., A 11502 Marshall, H. F., C 11603 McGovern, V. J., F 10972 Macholda, F., D 10801 Marshall, R., E 12082 McGrew, E. A., C 10763 Machova, J., A 10625 Marshall, W. J., Jr., E 12395 McIlvaine, P. M., A 11610 Machura, B., E 11029 Martens, J. H., C 10466 McIntosh, H. D., A 10638 Mack, A. J., A 12328 Martin, E., E 10477 McIntyre, J. A., F 11981 Mackay, 1. R., F 11221 Martin, J. k., E 11457 Mclaaac, R. J., A 11804 MacKay, J. 8,, B 11312 Martin, P., E 11379 McKennell, A. C., C 10668. C 11698. MacKenzie, H. M., A 12532 Martin Santos, F. J., D 11026 J 12560 Mackie, B. S., C 12303 Martinet, I., C 11904 McKenzie, H. I., D 12543 Macklem, P. T., A 12089, Martinez, R. D., E 10770 McLean. A. E. M., A 10901 D 11684, D 12098 Maruyama, T., C 12195 McMurray, C. M., F 11629 Macleod, W. M., D 10891 Masclrello, M., E 11730 McNamara, J. J., C 10246 Madishon, 8., C 11128 Mash's°, K., E 10620 McNamara, P. M., E 102r, E 11781, Macnicol, P. K., A 12614 Masnatta, C., E 12042 E 12263 Madey, J., C 10449 Mason, M. K., C 12017 McNeely, B. U., C 12325 Madill, H. D., C 12715 Massentinl, F., A 11166 McNicol, M. W., D 12756

320 324 McSweeney, E. D., Jr., A 12478 Mitchell, R. S., D 10510, D 11157, Morris, J. N., B 12348, E 11815 Meade, T. W., E 10243 (see also Mitchell, S.) Morrison, C. F., A 10636, C 10343, Medovy, H., J 10727 MIhll, S.,E. 12296, (see also C 11121, C 12548, C 12549 Medvedev, V. P., E 10432 Mitchell, R. S.) Mortimer, R. H., C 10401 ?lees, H. L., K 10533 Mitt, L., D 11675 Morton, A., D 12339 Mehta, F. S., C 11021, C 12170, Mitic, D., A 11169 Morton, D. L., A 10684 C 12413, F 12333 Mitolo-Chieppa, D., A 10205, Mosca, A., C 10524 Meinsma, L., 8 11844, C 12226 A 12446 Moshy, R. J., A 10226, A 11191, ?kites, J., A 11001, A 12313 Mittel, M. M., C 11979 A 11199 Melamed, M. R., C 12104, C 12766, Miyakava, M., C 10309 Mosin, V. I., F 11473 C 12770 Hobbs, B. C., A 11819, A 12665 Moskowitz, E., D 12275 Melthionne, S., A 10962, A 12122 Mocan, R., A 12396 Moss, F. E., J 10662 Hence, A., D 11839 Mody, J. K., A 11800 Mostofi, F. K., C 11385 Maliklan, A. P., A 12119 Modreleveki, A., E 11276 Mostyn, E. M., E 12080 Meloni, C., E 10514 Moegling, C., A 10789 Motoji, H., C 10419 Meluzin, J., C 12806 Moellering, R. C., 11 10643, (see Moulinier, J., D 10475 Mendes, J. J. A., A 12663 also Moellering, R. C., Jr./- Moulton, J. E., A 11291 Menoig, H., C 12502 Moellering, R. C., Jr., E 10878, Mounat, A., A 11177 Menotti, A., E 10514 E 12553, E 12554, (see also Hourdjinis, A., E 11659 Meng, H.-P., A 10694 Moellering, R. C.) Muckter, H., A 11614 Meranze, D. R., A 10928, Mohanty, P., D 11306 Mudrinic, F., D 12134 A 11134, A 11139, A 12109, Mohr, U., A 11007 Mueller, H. S., E 11154 A 12469 Mojonnier, L., E 10783, E 11695 Mueller, M., 1 12173 Mercier, J. N., E 11825 Mokhsnachev, I. C., A 11207, Muir, C. S., B 11022 Mercker, P. C., A 11735 A 11208 Mukai, F., A 11892 Mertens, C., E 12799 Moldenhauer, W., A 11197 Mukerjee, A. B., E 10400 Reserve, W. C., 1 10661 Mollaret, J., C 11350 Mukherjee, A. L., C 10815 Mesrohian, A. Z., A 12744 Molnar, L., F 10462 Mulcahy, R., D 10919, E 10306, Meseart, B., C 10898 Mombelli, L., A 10879 E 10453, E 11639, E 12282, Messite, J., D 10329, D 10448 Homage, S., C 10439 E 12344, E 12550 Metcalfe, J., E 11659 Monagle, W. J., K 10283 Muller, R., A 11197 Meyer, J. S., C 12261 Mondragon, M. C., A 10912 Muller-Dietz, H., E 11345 Meggasalma, G., E 11458 Monekosso, G. L., P 10890 Munn, A., C 12106 Micheal, 8. -C., D 11941 !Wolf, N., B 10915 Munro, J., A 11361 Michel, F. B., C 11963 Montagne, W., A 10492 Murata, H., A 12826 Mittel, I., A 11139 Moonily°, D. A., A 10281 Murnaghan, D. J., E 12344 Mithie, M. J., A 12632 Montana, G. S., C 11791 Murovich, B. V., K 10206 Michigan Youth Commission, Montesano, R., A 10454 Murphree, H. B., E 12451 J 11579 Montesinog, F., F 10621 Murphy, E. A., E 10218, E 10847 Mickey, M. R., A 12138, A 12464 Moolten, S. E., C 12288, D 12084 Murphy, C., A 11406 Middleton, C. C., E 10913 Moon, R. C., A 11423 Murphy, R., D 11231 Miech, C., C 10541 Moore, C., C 12835 Musick, R., A 10587 Miele, E., A 12181 Moore, G. E., A 10222, F 11629, Mustard, J. F., E 10218 Miettinen, M., E 12244 I 11554, J 10240, J 11323 Mustea, I., A 11023 Mihailovich, N., A 10399 Moore, M., A 11097 Mute, N., C 10209 tither', R., F 11919 Moore, 0. S., C 12416 Muysers, K., D 10730 Miles, J. T., E 10460 Moore, R. B., E 11812 Myers, W. P. L., C 12790 Millar, J. D., A 10229 Moore, R. J., J 10391 Myre, M., D 12539 Miller, A., C 11482, E 11913 Morales, I. B., E 10257 Myrsten, A.-L., A 10583 Miller, C. E., D 12090, D 12091 Moran, F., D 10348 Miller, E., A 11645 Morand, C., C 10541, C 11805 Miller, F., A 11227, E 12283 Norden, J. S., B 11269 Miller, G. W., A 12233 More, E., A 11614 Miller, I. 8 10616 Moreno Torres, A., C 12194 Miller, R. L., A 11205 Morgan, K. R., C 10274 Miller, W. A., E 11695 Morgan, W. K. C., A 11224 Nadeau, R. A., A 12392 Mills, S. E., A 12593 Mori, W., A 12716 Nadel, J. A., A 12089, D 12074 Milutinovic, P., E 12185 Merl', S., A 11811 140, 1., C 10472 Minemi, Y., C 10419 Moriaoto, M., F 10985 Nadjofi, A., D 12078 Minette, A., D 11767 Morita, R., C 10419 Noeye, R. L., E 12523 Minkler, J. L., C 10772 Mork, T., C 11694, J 10948 Mogan°, M., E 12083 Misenheimer, J. R., A 11198 Moroni, E., D 11675 Nosagava, H., A 10932 Alsievice, J. J., A 11149 Morooka, T., S 12531 News, C., A 10822, A 12745 Mite, M., A 12699 Morozov, G. N., F 11870 Nagle, R. E., E 11254 Mita', V. P., C 12002 Morozzi, C., A 12454 Nahmlas, A. J., J 12718 Mitchell, 2. p., C 11482 Morrell, M. T., E 12082 Neigh, P., F 11222 Mitchell, R. I., A 10225 Morris, H. P., A 11795, A 12463

321 52 6". Nakajima, H., C 11267 Nilsen, E., J 10948 011er Corominas, F., C 11771 Nakajima, T., C 11267 Nilsson, S., A 12331 Olmedo, C., D 11525 Nakamura, K., C 10188 Nishimura, M., C 11267 Olson, D. E., D 12059 Nakamura, T., A 11249 Nishimura, R., A 11999, C 10605, Olson, P. R., A 12266 Nakatani, H., E 11417 C 12730 Omoto, T., C 10439 Nakayama, K., A 10331 Nishizuka, Y., A 10963, A 11071, Ondok, J., C 11295 Nanovic, R., C 10471 A 11136, A 12338 Ondrej, M., F 11309 Napalkov, N. P., A 10757, Noack, C., A 11741 O'Neal, J. D., E 10568 A 11982 Noble, J. F., A 11803 O'Neal, R. M., A 12594 Nasello, A. C., C 11607 Nogucht, H., A 11175 O'Neill, R. P., A 12183 Nash, D. R., A 11995 Noojin, R. 0., F 10268 Onitsuka, H., C 12361 Nassif, R., C 12311 Noring, 0., C 11101 Opinion Research Corporation Natelkar, M. V., B 11017 Norman, J., D 12275, (see also Caravan Surveys, Inc., J 10387 Nath, A., C 12008 Norman, J. R.) Opler, S. R., A 11075 National Center for Health Norman, J. R., F 10498, (see Oppenheimer, B. S., A 12595 Statistics, B 11499, B 12527, atso Norman, J.) Oppenheimer, D. R., A 11137 P 10540, J 11410 Norman-Taylor, W., J 11138 Oppenheimer, E. A., D 11109 National Health and Medical Nothdurft, H., A 12596 Oppenheimer, E. T., A 12595 Research Council, J 12612 Novak, K., D 12805 Orha, I., D 12231 National Institute of Malth, Novaro, A., E 11928 Orie, N. G. M., C 10702 B 10816 Novak, L., J 12821 Orihata, H., C 10419 National Interagency Council on Novak, S., E 11029 Oriol, A., D 11699, D 12079 Smoking and Health. J 11321 Noyes, W. F., A 11630 Orlovskiy, L. V., C 10196 National Tobacco Board of Nunez, I. P., C 11964 Ormandy, A., A 11193 Greece, A 11161 Nunez, L. E., E 12083 Ormos, J., B 12809 Nau, C. A., A 11787 Nunn, J. R., C 11789 Orndahl, C., E 11634 Navin!, H., C 12459 Nuzzolillo, L., C 1175: O'Rourke, A., J 10258 Nayak, K. C., E 12347 Otr, J. W., A 11257 Neal, J., C 10437 Osada, H., A 10777, A 11085, Nebert, D. W., A 10255, A 12795 A 12372, F 12486 °Ours,. H. S., C 10425, C 12762 Nedeljkovic, S., E 12185 Oselett, B., B 11407 Nedergaard, O. A., A 12411 Osogoshi, K., C 10419 Neff, C., E 10549 Ober, W. B., C 12341, C 12409, Osswald, H., A 11024 Negreiros, B., D 10705 E 12251 Ostling, E., D 10794 Negri, M., E 10327 Oberwlttler, W., E 10611, Ostrander, L. D., Jr., E 11793 Neiders, M. E., A 12171 E 10707, E 11949, E 12362 O'Sullivan. N., J 1025g Nelson, N., D 12703 Obeyesekere, I., E 12316 Osantokun, B. 0., F 10890 Nelson, R., A 11289, (see also O'Brien, R. L., A 12405 Otsuki, K., C 11267 Nelson, R. L.) Ochoa, M., Jr., C 12152, C 12177 Ott, A., C 11965 Nelson, R. L., A 12160, (see Ochsner, A., C 10726, C 10866 Oudet, H. P., D 11363 also Nelson, R.) O'Connor, K. J., A 11232 Oudet, P., C 11865 Nelson, V. C., A 11610 Odashlma, S., A 11483 Outhred, K. C., D 12543 Neri, A., A 10583, F 12304 O'Day, D. M., D 11301 Ouzounov, N., B 10915 Nery, R., A 12653 O'Doherty, E. F., E 12550 Owen, J., A 12492 Nesbitt, R. E. L., F 11697 Oehlert, W., F 11467 Ozaki, H., C 10188 Nesemann, E., A 10210 Oettel, H., C 12199, C 12212, Ozkan, N., A 11181 Nesnow, S., A 11663 E 12201 Ozyolcular, N., A 11181 Nett, L. H., D 10748 Ogan, E., C 12412 Neukomm, S., A 11553 O'Gara, R. W., A 11915 Neurath, C., A 10833, A 10952, Ognyanov, I., A 10875, A 11187 A 10953, A 11184, k 11186, Ohrt, D. K., E 12001 A 11204, A 12045, A 12356 Ohtake, S., A 11803 Newhouse, H. L., B 12752 Ojtma, Y., A 12700 Newman, I. H., J 12538 Okada, K., C 10309 Paaby, H., E 12732 Newman, R. H., A 10718 Okajtma, E., A 12287 Pachman, D. J., J 10276 Newman, V. P., E 10770, E 12145 Okamoto, Y., C 11009 Pacuraru, R., A 10771, D 11150 Newton-Moves, J. S., D 12030 Okita, G. T., A 12137, A 12690 Padmavatt, S., E 12031 Nicatse, A.-M., F 11540 Minder, C. A., E 10906 Paffenberger, R. S., Jr., E 12137, Nichaman, N. Z., E 10257 Olds, H. E., A 10957, A 12702 F 12136 Nicolay, R. C., J 10486 Olejnicek, H., C 12806 Page, H. A., A 10442 Niden, A. H., D 12057 Oleetkiewica, L., C 12813 Page, N., D 12255 Nielsen, J., C 12591, E 12507 Oltvares, H. A., C 11964 Psi, M. P., E 12347 Nikacevtc, M., A 11169 Oliver, M. F., E 11983 Pain, H. C. F., D 12086 Nikki, P., A 11)04 Oltverto, A., A 10979, C 10575, Palauldessi, C., B 12040 Nikulin, K. C. D 10817 C 10588 Palecek, F., D 11)02

32:4 Paleetto, C., A 12355, A 12357 Perna, L., C 10523 Palmer, K. N. V., E 10600 Polonoveki. J., A 81371 Perrin, 1.-F., A 10550 Polotebneva, N. A., A 11850 Panetzolo, A. A 11535 Ptrry, H. 0., F 10864 Pspadopolu, C., A 11934 Poluboyatinove, Z. I., A 12708 Pevelmiltl, J., B 10316 Polyak, N. R., A 10521 Papaloamnou, A. N., C 12784 Petchiateekt, C., A 11195 Papoyan, S. A., A 12711 Pool, J. L., C 12769, C 12771 Peter., H., F 11311 Pam-King. r.. 8 11243 Pappajohn, D. J., A 10777, Petersen, F. B., E 10604 A 11085, A 12795, A 12798 Popham, R. E., C 12757 Peterson, B. Ye., C 11875 Popov, T., 8 10915 Pappas, N. A., A 11203 Petite, J.-P., C 11459 PoP0v, N. D., A 11172 Parade, D., E 11952 Petrakov, R. D. 8 12816 Parade, C. W., 8 10627 Popov.. L. P., A 11207, A 11218 Petrilli, F. L., D 10416 Poppers, P. J., A 10377 Pardal, C., E 12042 Petty, T. L., D 10748 Poros, Z.. D 11268 Pardo., P., C 11971 Peyrot, J., A 10609 Porta, C. D., A 10337 Parfemov, Yu. D., A 12708 Pfaltc, C. R., C 10849 Porter, F. T. H., J 11292 Patient., R., D 12367 Pfander, W. H., A 12399 Porter, N. S., A 11474 Parker, D. A., C 12676 Hitter, E. A., A 11130 Porteann. C., C 11971 Parker, J. H.. C 12715 Phillips, C. I., P 12153 Possick. P. A., C 11508 Parkes, H. C., C 12103 Phillips, R. P., C 12777 Post, S., A 10583 Parkin, R., A 12577 Phillips, S. J., C 12768 Postillion., C., E 11537 Parkomenko, I. I., A 11021 Plaget, P., C 11356 Parka, A. G., A 12305 Postupal'skiy, Ya. N., A 12818 Piancone, R. M., E 10327 Potekhina, H. V., 8 12709 Parks, V. R., A 10292, A 11229 Pilate, H. H., E 11362 Potkonjek, V., 12 12132 Parrish, C. H., C 12729 Pith., E., C 11950 Pound, A. W., A 10358 Parrish, N. 11., E 12142 Pick, R., E 12317 Pound, S., A 12563 Parrot, 1.-1., A 10323, A 10544 Pickart, L. R., E 10518 Poveda, J., C 10626 Parry, S. W., A 11077 Pickering, D. E., J 12118 Powell, A. K., A 12518 Parsons, W. B., Jr.. 1 12738 Pirkreu, J. W., E 10262 Powell, J., K 10504 ?allelic, H., D 12132 Pierach, A., A 10708 Pascual, E., C 10626 Pozharisekt, K. M., A 11982 Pierqutn, B., C 11539 Pratt, P. C., D 12066, D 12093 Paskaleva-Tonova, K., A 11189 Plestrak, J., E 11029 Pratt. S. A., D 11446 Passey, R. D., A 12568, A 12639, ['tette, Y., A 11615 Praiser, F. M., D 12168 A 12681, A 12682 Pagers., L. 0., E 10518 Prerovsky, I., 8 12491 Pastorelli, S., C 11279 Plikington, T. R. E., A 10553 Preston, R. L., A 12399 Pastorova, J., 8 11450 Pillsbury, N. C., A 11232 Preuss, 8.-C., E 11132 Pataki, J., A 10926, A 11811 Pindborg, J. J., C 11021, C 12170, Preussmann, R., A 12306 Patch., L., A 11195 C 12413 Trice, J. N., C 12006 Patel, J., C 10683 Pinkerton, K., A 11613 Prichard, R. W., E 12146 Patterson, J. H., A 10587 Pinol Aguade, J., C 11771 Prtneas, R. J., D 10512 Parka, H., B 12541 Pipkin, C. E., A 11999. C 10605. Paul. D., A 11619 Pringle, J. A. S., A 11156 C 12730 Prodl, C., A 10941, A 12824 Paul, 0.,E 10991, E 12241 Psrcher, F. J., D 12097 Pauli, c., C 11885 Proscia, N., D 10695 Pirlet, K., E 11944 Provana, A., A 12355 Paun, D., K 10414 Pireamn, I., A 11186 /Wan. N. M., E 12526 Prusova, F., IS 11450 Pies, Z., E 10514 ?lyre. D. N., A 17666 ?floret, 0. E., A 12613 Piscaglis, H., B 11375 Persaglia, P. C., A 11847 Public Health Statistics, Department Plsklov, V. F., A 11207, A 11208 Of Health, Fa., 8 10828, Petcock, P. R., C 11635 Pistewke, H. J., D 10865 8 11567, 8 11785 Pearce, M. L., E 11816 Place, R. E. C., D 11699. D 12079 Pugh, D. L., D 12255 Pedersen, E., C 11048, C 11694 Plageann, H.-C., C 11868, F 12210 Pedersen, T., A 12112 Punt, N. A., 11 11505 Platt, D., A 11780, (see also Puri, P. S., E 12196 Pekkarinen, N., E 12244 Piste, D. S.) renter, S., C 11676 Puri. R. K., 3 11449 Platt, D. S., A 11079, (see also Putt, C.. D 11932 Peloso, J., P 11898 Plitt, D.) Feller, A.-M., D 10775 hbus, R. J., C 10632 Platt, E. S., C 12842, K 10579 Pyle. R. L., F 11900 Ferman, R. W. B., D 12058, PlesasntO, F., Jr., F 11676 0 12081 Pylev, L. N.. A 11911, A 12569, Plechl, S. -Ch., E 11546 F 11147 Pennsylvani Committee on Smoking Plishner, H. J., D 10482 Pyrah, L. N., A 12400 and the Health of Youth, Plitt, C. 11., A 11313 J 12369 P. Lorillard Cowpony, A 10947 Penny, J. L., E 11154 Pobee, J. 0. X., C 12466 Percival, W. H., A 11099 ocimou. 0., D 10470 Peretti, S., A 11282, A 11284 Polettl., A., A 11360 Perini, C., E 10322 Pollard, N., A 12256 Perlman, L. V.. E 11793 Politer', A., A 10640, A 12407, ferule, I., C 10698 Questel, J. H.. A 11416 A 12488 Quinn, H. J., Jr., C 12749 Pollock, N. 8., J 11129

323 327 Raab, W., E 10785 Restivo, R., E 12748 Rose, C., D 10512, (sea also Rabukhin, A. Ye., C 11874 Rethelyi, J., J 12802 Rose, G. A.) Racugno, V., C 11854 Reuber, M. D., A 10251, A 11809. Rose, G. A., E 10514, (see also Radford, E. P., A 11723 P 11315 Rose, G.) Radomeki, J. L., A 11893 Reuter, W., D 11369 Rose, R. J., E 12279 Rady, R. 8., D 10597 Reznikoff, M., J 12373 Rosellini, A. D., J 12623 Rakover, J., B 10406 Rhoades. J. W., A 10229 Rosemond, G. P.. / 12469 Rakusan, K., A 12534 Rice, K. B., J 12625 Rosenberg, A., A 12396. A 12438 Randial, S., 8 11243 Rich, P., A 12418 Rosenblatt, D., J 10670 Ramsey, J. M., A 11529 Richards, A. B., A 10374, A 10423, Rosenblatt. G., E 10643, E 10878, Renadive, K. J., A 12011 (see also Richards, 8.) E 12553, E 12554 Rengan, S. R. S., C 10815 Richards, B., B 12723, (see oleo Rosenblatt, H. B., B 11425 Rankin, J. G., D 11301 Richards, A. 8.) Rosenbiuth, A., D 12070 Rao, B. S., E 12062 Richards, E. C., D 12064 Rosene, C. J., A 11667 Rao, L. G. S., C 11113 Richter. H., E 11944 Rosenfeld. L., C 12404 Rapp, F., A 11069 Ricketts, H. J., D 12067 Rosenkrante, H., A 11015, A 11297, Rapp. H. J., A 12378, A 12379, Riedel, R. G., J 10486 A 11881 A 12380 Rigdon, R. H., C 10437, C 10538 Rosenman, R. H., E 10261, E 10899 Rasheed, S., A 12662 Rijhsinghani, K., D 10867 Roskamm, H., E 11466 Rasmussen, L. H., C 12787 Rikimaru, S., G 12195 RoStassith, J., 0 10641 Raaulev, Sh. I., A 12506 Rime, B., E 12799 Rosnati, V., A 12119 Ratcliffe, H. L., E 11990 Rimington, J., C 11583, E 12556 Rosa, A. E., A 11917 Rathkamp, G., A 10207. A 10949, Riopelle, J. L., A 11019. A 11460 Rosa, H., A 11403 A 11663 Rosenberg, A., C 11219 Ross. W. L., C 10889, C 12829 Ratliff, J. W., Jr., F 11678 Roach, W. A., C 11789 Rossi, A., D 12825 Raven, R. W., C 12309 Robb, E. W., A 11209 Rossi, S., A 11202 Ravenholt, R. T., E 12149 Robbins, W. T., J 10491, J 11331 Rotblat, J., A 12663 Ravens, K. G., E 12200 Roberts, A. H., C 11887 Roth. G. M., E 11779 Raventos, A., C 10813 Roberts, D. M., P 10582 Roth. L. J., A 11066 Raventos ?forages, A.. C 11771 Roberts, N. J., 8 11792 Rothblat, G. H., A 10355 Rasa, M., E 10810 Robertson, D. G., D 11251. D 12030 Rothwell, K., A 12750 Read, J., D 12086 Robertson, M. A., C 12274 Rottini, E., F 10818 Reader, R., E 12496 Robin, E., E 12200, E 12447 Roumagnoux, J., C 10467 Reale, A., E 11542 Robins, A. B., D 10482 Roux, A., E 11548 Rechsteiner de vos, H., E 10379 Robinson, J. C., A 10230, A 10933 Rovin, S., C 10371 Racine, G., E 11752 Robinson, R., D 11404 Rowlands. J. R., A 10281 Reckteh, G., A 11005, A 11037, Roche,, P. J. L., B 11022 Raman. D. G., A 11245 A 11866, F 11040 Roehova-Mikuleakova, J., D 11302 Roy, S., A 12674 Reddy, D. B., A 11552 Rochu, P., E 11773 Royes, D., J 12626 Reddy, D. G., A 11552 Rodsllec, A., A 10547 Rubin. P., C 10278 Red'kin, Yu. R., A 10199 Rodic, S., P 10800 Rucker, K., A 11037, D 11849 Reed, E., D 12406 Rodkey, F. L., E 10568 Ruddon, R. W., A 10386 Reese, W. H., Jr., A 12613 Rodman, T., D 11230 Ruff, F., A 10323. A 10544, A 11772 Reffi, A., D 11274 Rodrigues, A., A 10392 Rufty, A. J., Jr.. E 10797 Registrar General's Statistical Roe, F. J. C., A 10756, A 10971. Rulliere, R., C 11543 Review of England and Wiles for A 11099, A 11606, A 12022, Rush, B. F., C 10371 the Year 1962, Part III, A 12257, A 12566, A 12569, Rush. M., A 11080 C 10395 A 12571, A 12572, A 12652, Rusk. H. S., A 10631 Regli, J., D 11876 A 12654, A 12657, A 12686, Ruskin, J., A 10638 Reiehel, G., D 10637 F 11247 Russell, C. S., F 10370 Reichle, F. A., A 12469 Roegholt, H. N., C 11838 Russo, C., C 11377 Reid, D. D., D 11519, E 10811, Boesch. R. P., A 10423 Russo, C., E 11569 E 12365. E 12559, E 12617 Rogers. J. A., E 10797 Rwomushans. J. W., A 12407 Reid, L., 0 10598, D 12522 Rogers. W. K., D 11409 Ryan, G. M., C 12774 Reid, W. W., A 12632 Rohrbach, R., A 12450 Ryan, M. P., E 12344 Reif, E., D 12211 Roinm, P., E 12244 Rybakova, M. C., A 11527 Reindt11, H., B 11466 Rojas. L. L., C 11966 Rylander, R., A 10235, A 12114, Reinke, C. M., A 10350 Roland, C. C., F 12298 D 10725. D 10779, P 11047, Reisfeld, R. A., A 10684 Rollo, K. A., E 11794 J 10240 Reiskin, A. B., A 11996 Romagnoli, C., E 11766 Rytel, A., E 11884 Rendon, A. M., 8 11864 Romer. K.-H., C 12433 Ranier, A., A 11164 Romero, C. A., A 10392 Rentchnick, P., J 10300, J 14681 Roncsri, G., A 10879 Rentsch, H. J., E 11953 Rondis, D., A 11943 Reich. J. A., F 10916 Rosado, A., A 12463 Resnik, F. E., A 11063 Rose, E. F., A 12384. C 10347

324 Sachs, H., B 12541 Scaasellati Sforzolini, G., Schwartz, D., A 11782 Sackett, D. L., E 10262, A 11372, A 11376 Schwartz, T. L., A 10584, G 10663, E 12021 Scevola, A., C 10802 J 11664, K 10529, K 11696 Sadler, M., J 10341, J 11487 Schaefer, H., E E 11738, K 12036 Saffiotti, U., A 10336, A 10454 E 11856 Schwartz, M. J., E 11781 Safta, L., A 12396 Schaefer, K. E., D 12r/2 Schwarz, K., F 11445 Sager, R. V., E 11382 Schaefer, V. J., F 1, 1.7 Schwarz, M., D 11347 Said, S. I., D 12085 Schaller, R.-H- .1531 Schweinsberg, F., A 10694 Saindelle, A., A 10323, A 10474, Schamaun, 12206 Scianaro, L., A 11847, F 10818 A 10544, A 11772, A 12453 Schar, B 12504, D 11879, Scillieri, E., D 10468 Saint Clair (see St. Clair) E 119 , E 11974, J 11764 Scoppetta, V., L 11283 Saito, T., A 12713 Scharf berg, G., K 10413, K 11852 Scott, M. L., A 12342 Saltamoto, K., C 10419, C 10439 Schaude , A 11757 Scott, N. C., A 12758 Saker, B. M., E 11794 Schein, P. ., A 11801 Scott, W. G., C 12482 Salazar, J. S., E 10477 Scherbaum, H., A 11768 Scriabine, A., A 12795

Silber, E. J., G 10669 Scherrez, I D 10803 Scutchfield, F. D., A 11489 Saldana, M., E 12060 Schettls'. C. i 10846 Searle, C. E., A 12672 Salver, J. S., A 11595 Schievelb,_ d., A 10831, Sears, A. D., C 10246 Salvaggio, J. E., D 12390 A 10832, A 10834, A 10836, Soda, H. 3., G 11386 Samochernova, L. I., D 10817 A 10840, A 10872, C 10852, Seehofer, F., A 10210, A 11265, Samoylovich, L. N., A 10199 C 10855, J 10872 A 11287 Samuel, R. C., C 12459 Schildwachter, C., D 12203 Segal, A., A 10228, A 12712 Sanchez, A., C 10626 Schilli, W., F 11467 Segers, M. J., E 12799 Sanchez, V., A 11902 Schilling, R. S. F., B 12262, Sal, M., C 10419 Sanchez Carvajal, M. A., F 11351 D 11673, D 12688 Seidel, H. J., A 10731 Sander, J., A 10694, A 12540 Schimmler, W., E 10549 Seize, K., E 11732 Sanders, F. K., A 12123 Schipfer, L., A 11167 Sekihara, T., D 12059 Sanderson, K. V., A 12664 Schirren, C., F 10853, F 12220 Seligman, R. B., A 11209 Sandhu, 1., E 12031 Schlegel, J. U., A 11999, C 10605, Selikoff, I. I., B 12551 Sandifer, S. H., D 12691 C 12730 Sellers, C. M., A 10558, G 12548 Sandor, P., E 11945 Schlesinger, M., A 11076 Sellwood, R. A., E 11379 Sanghvi, L. D., F 12333 Schlierf, G., E 11826 Seltmann, H., A 11403 Sano, L., C 11056 Schlotterer, M., E 11548 Seltzer, A. P., C 11665 Sano, N., A 10331 Schlotzhauer, W. S., A 12046 Seltzer, C. C., E 11463, E 11834, Santais, M.-C., A 11772, A 12453 Schmahl, D., A 10201, A 10839, E 12245 Santanaria, J. N., D 11301 A 11024, A 11758 Semczuk, B., B 10316 Santamaria, L., A 10946, A 11863 Schmaman, A., C 11912 Semeraro, S., E 11370, E 11374 Sant!, L., C 12823 Schmaltz, I., A 12046 Sen. H., 8 10954 Santoro, L., A 11535 Schmid, F. A., A 12023 Senior, R. M., D 12064 Santrucek, M., E 10767, E 10804 Schmidt, F., J 12364 Senkus, M., A 10372 Sapin-Jalouatre, H., A 11541, Schmidt, S., C 11998 Sepahe, C. C., E 10992 K 10610 Schalterlow, C. G., A 10325, Sequeira, L., A 11013 Seplis-Rrasouska, L., J 10427, A 11148 Serdjuk, L. C., A 11207, A 11208 J 11277 Schmitt, G., E 11743 Serraro, P. A., A 12606 Seraste, K., C 11087 Schnarr, W. R., E 11990 Staab', G., A 10712 Sardet, C., A 10355 Schneider, F. H., A 12737 Seylaz, J., F 10462 Sargent, T., D 10294 Schnitger, F., A 11360 Sficas, A. G., A 11163 Sernoweka, I., F 12359 Schoenberger, J. A., E 11748 Sgarbi, M., E 10319, E 11730 Sasser, W. F., C 10692 Scholfield, C. N., A 12739 Shabad, M. L.-M., A 10191 Sataline, L. R., D 11337 SchQnland, M., C 11776, C 12374, Shafer, W. G., C 12832 Sato, H., C 10419 C 12386, J 12587 qbah, D. R., F 11391 Sato, K., C 10404 Schnop, W., E 11862 Shiheen, 0. H., C 11824 Sato, N., E 10368, E 10620 Schottenfeld, D., C 11393 Shambaugh, G. E., Jr., D 11784, Satyr, N. A., D 11271 Schroder, J., E 10857 J 10509 Sauleau, P., C 11459 Schroder, R., A 10210 Shamberger, R. J., C 11246 Salvino, A., A 11280, A 11372, Schroeder, H. A., 1 11434 Shamray, Ye. F., A 12193 A 11376 Schroder, R. C., E 12276 Shanker, P. S., E 10993 Savitt, R. A., G 11072 Schultz, C., A 11736 Shapiro, J., D 10329, D 10448 Sawicki, F., D 11039, J 11737 Schultz, R. E., E 12451 Shapiro, S., E 11382 Saban, E., C 11694 Schultze, H., A 11531 Sharma, A. K., A 12382 Santana, R. C., A 11662 Schula, E. K., A 10872, (see also Sharma, M. L., C 11979 Sayegh, F. S., A 11135 Schulz, K.) Sharma, 0. P., F 11222 Sayenko, A. J., C 10896 Schulz, K., D 11941, (see all,o Sharp, D. V., F 10768 Saylor, L. F,, B 10873 Schulz, E. K.) Sharp, H. L., F 12158 Scanlon, P. W., C 10710 Schuster, G., A 11180 Shatsky, S., D 10293 Scarps, T., A 11535 Schutt*, H. R., A 10522 Shatton, J. 11.. A 11795 Scarpelli, E. M., D 11722 Schutz, J., D 11941 Shave L., A 11403

325 32,9 Shchechkin, V. N., C 10608 Sims, P., A 12494, A 12563, Soule, E. H., C 10710 Shea, J. J., Jr., F 11451 A 12565, A 12634, A 12636, Soyusenc, R., E 10783, E 11695 Shear, M. J., A 11475 A 12651 Spagna, I., E 11374 Shedd, D. P., 11 10465, C 11724 Sims, C., A 11023 Spahn, U., F 11958 Sheen, S. J., A 10376 Sindoni, L., J 11577 Spain, D. M., D 10718, E 10537 Shekelle, R., E 12748, (see Singh, S. A., C 12008 Specht, C., C 10628 also Shekelle, R. B.) Singh, S. V., F 12391 Speiser, F. E., D 10722 Shekelle, R. B., D 10978, (see Sirotenko, A. A., A 11107, Spengler, C. H., E 11974 also Shekelle, R.) A 11208 Spevak-Marinkovic, Lj., D 12134 Shende, C. Y., C 10279 Sirtori, C., C 11751, C 12605, Spezia, C. A., A 10561, A 11808 Shephard, R. J., D 10559 J 11753 Spicer, S. S., F 12032 Sherman, C. D., Jr., I 11623 Sisson, C. A., C 11090 Spiegel, H., J 11655 Sherman, M., D 12840 Sivak, A., A 10228, A 10352, Spiegelman, J., D 12703, (see Sherman, R. S., C 12768 A 10962, A 12122 also Spiegelman, J. R.) Sherwood, K. K., 11 11560 Sjolin, K.-E., C 12820 Spiegelman, J. R., D 10293, (see Shetty, A. S., A 12233 Skarabellova, M., D 10470 also Spiegelman, J.) Shibata, S., A 10812 Skinner, E. F.,11 11147 Splgliati, P., B 11368 Shimkin, M. B., A 10332, Skinner, M. E. C., C 12676 Spillane, J. D., F 11261 A 10928, A 11134, A 11139, Skyring, A., F 10654, F 12179 Sprague, R., A 11297, A 11881 A 12109, A 12469 Slack, J., B 10601 Sprott, J. S., Jr., C 10715 Shintani, K., A 10417 Sladek, N. E., A 10861 Springer, K., A 11291 Shirai, J., D 11538 Slavkovic, V., E 12185 Sprott, D. A., 11 12175 Shirai, Y., C 10419 Slowinski, E. J., C 10299 Stadll, F., E 12732 Shires, T. K., A 1160. Smart, C. R., C 11456 Stadler, L., A 11005, A 11955, Shisa, U., A 11071 Smetanin, E. Ye., D 12353 F 11040 Shishlcin, V. F., A 11987 Smidt, U., D 10730 Stahlhofen, W., F 10858 Shklar, C., A 10366, A 11420, Smith, A., B 12723 Stahr, H. K., A 10445, A 11067 A 11497, A 12528, A 12744 Smith, C., A 12641 Stalev, St., A 11189 Shore, S. R., A 11440, D 11611 Smith, C. J., A 10774, A 10826, Stamenkovic, E., D 12134 Short, J. C., C 12260, D 11481 A 12642, A 12684 Stamler, J., C 10446, D 10978, Short, M. D., D 11132 Smith, C. W., A 11787 E 10783, E 11695, E 12408, Shroff, B. C., F 12333 Smith, D. D., D 12691 E 127411 Shuba, E. P., A 12227 Smith, E. M., B 11586 Stamler, R., E 12748 Shuler, R. L., F 10357 Smith, E. R., A 10938 Standish, " L., D 10597 Shultz, C. N., A 11999 Smith, C., A 11452, (see also Stanescu, D., A 10771, D 11150, Sibley, J. C., E 12735 Smith, C. M.) D 12162 Siddiqui, M. K., E 12115 Smith, C. M., C 10841, (see also Stanford, R. E., C 12410 Sieber, S. M., A 11660 Smith, C.) ltanislawski, M., A 12449 Siedek, H., E 12222 Smith, M. H., D 11446 Stanley, E. L., E 12395 Siegel, W. A 11497, (see also Smith, M. M., D 11624 Stanley, T. W., A 10572 Siegel, W. V.) Smith, S. C., J 12733 Stanton, C., C 12152, C 12177 Siegel, W. V., A 11420, (see Smith, W. C., A 10445 Stanton, M., A 10933, (see also also Siegel, W.) Smith, W. T., Jr., A 10587 Stanton, M. F.) Siggaard-Anderaen, J., E 10604 Sneddon, A., A 10447 Stanton, M. F., A 11645, (see Sigurjonason, J., E 11259 Snow, J. B., Jr., C 11386 also Stanton, M.) Silber, I., C 10981 Snyder, F., A 11646 Stanton, R., A 12405 Silberman, II., A 11210 Snyder, C. B., C 11598 Stark, F. M., E 10280 Sillanpaa, V., C 10994 Sobin, L. H., C 11002 Stark, J. E., F 10924 Silverman, A. P., C 12558 Sobol, B. J., D 12275 Starrett, P. S., A 12731 Silverman, J. D., D 11428 Social Research, Incorpore.ed, Starsyk, H., C 12813 Silvers, C. W., D 11157 J 11692 Stastewski, J., B 11545, C 11788 Silvestroni, A., D 11365 Softer, A., E 11338 Staudacher, H. L., D 10734 Simeckova, B., C 10418 Sofoluwe, C. 0., B 11627 St. Clair, R., E 12146, (see Simic, A., E 12185 Solanke, T. F., C 12307 also St. Clair, R. W.) Simic, V., E 12185 Solari, V. S., A 11178 St. Clair, R. W., E 10959, (sec Sim)o, V., F 11000 Soliven, F. A., A 11194 also St. Clair, R.) Sims, H. 0., B 12189, J 12217 Somogyi, A., A 12267 Stead, E. A., Jr., E 12746 Simmons, E., A 11493, (see also Sonnenblick, E. H., A 12794 Stectkowski, J., D 11039 Simmons, H. E.) Sorensen, B., C 11101 Stedman, R. L., A 10224, A 10408, Simmons, H. E., C 12371, (see Social*, F., D 10695 A 10476, A 10935, A 10936, also Simmons, E.) Sorni, C., F 12604 A 10937, A 11205, A 11227, Simon, J. L., 8 10576 Sorour, A. H., E 10729 A 12048 Slmonot, C., C 11350 Sosnik, H., C 12813 Steianovlch, V., A 12155 Simonsson, 80. C., D 11010 Soto, E., C 11890 Stein, M., E 12083 Simpson, M., B 12588, 8 12680 Sottosanti, M., C 10328 Steinberg, M. L., I' 10208 Steine, L., J 12755

326 330 Steinglass, M., A 12010 Sugiura, Y., D 11538 Ts, N.-N., C 11947 Steinitz, R., B 11916 Sugiyama, T., 1, 10354, A 11136, Teculescu, D A 10771, D 11150 Steinmann, B., D 11848 A 12338 Teeling-Smith, C B 10450 Stella, M., Jr., E 10874 Suhs, R. H., To 11127, D 11429 Tegner, Y., A 10986 Stell, P. M., C 12323 Sultanov, S. 4., A 12506 Teichman, V., D 10801, D 12805 Stelzer, 0., D 12503, E 11738, Summerell, J. M., D 12489 Teller, M. N., A 11595 E 11856 Sumney, D. L., A 11780 Temesvary, E., J 12804 Stenersen, S., J 12627 Sun, D. C. E., F 12032 Teng, P., B 11425 Stenhouae, N., E 11794, (see Sunas, E. C., A 10543 Tennekoon, C. E., C 11252 also Stenhouae, N. S.) Sundell, L., A 12020 Tephly, T. R., A 12299 Stenhouse, N. S., D 11294, Suppa, C., E 11458 Terracini, B., A 10337, A 11924 E 11599, (see also Stenhouse, Suss, R., A 11007 Terris, M., F 10361, J 11734 N.) Suzuki, H., A 11249, A 11823 Terry, L. L., J 12476 Stephan, U., A 10522 Suzuki, F., E 11888 Terzuolo, D., E 11754 Stephens, E. J. W., A 12574 Svoboda, V., C 11078, C 11295 Tesanovic, M., F 10800 Stephens, R, J., D 11158 Svobodova, A., J 12814 Thakerngpol, K., B 12165 Stephenson, J. A., C 12549 Swain, A. P., A 10935, A 10936 Thatcher, D., A 10928 Sterling, F. H., D 11230 Swann, ?. F., A 10245, A 11240, Theuann, H., E 11743 Sterling, T. D., 8 10494 A 12732, A 12575 Thibault, Ph., C 11957 Stern, E., A 12138, A 12464 Swanson, A. J., D 11798, E 12228 Thiede, T., C 11016 Stetsenko, I. P., A 12193 Swam, N., J 11062 Thiess, A. M., C 12199, C 12212 Stewart, B., A 12576, (see also Swencicki, R. E., D 10448 Thomas, C., A 11757 Stewart, J. B.) Sydnor, K. L., A 10633 Thomas, C. C., Jr., A 12492 Stewart, J. B., F 12419, (see Syed, S. A., E 10810, E 12115 Thomas, C. M., J 12584 also Stewart, J. B.) Szabo, D., A 11601 Thomas, H. E., E 11828, (see also Stewart, T. H. M., C 12025 Szadkowski, D., A 11531 Thomas, H. E., Jr.) Stewart, W. H., 1 11514, J 11327 Szelacs, S., J 12812 Thomas, H. E., Jr., E 10922, (see Stitnimankarn, T., B 12165 Szilagyi, L., J 12803 also Thomas, N. E.) Stjernsward, J., A 11290 Szcnyi, F., B 12809 Thomas, H. V., A 11493 Stock, J. A., A 12570, A 12640, Szydlowski, Z., C 12813 Thomas, J., D 12015 A 12641 Thomas, M. T., A 12012 Stocker, R., II11407 Thomas, N., J 10459 Stockmann, Y. A., E 10379 Thomasson, H. J., E 12294 Stocks, P., B 11988 Thompson, D. J., E 12350 Stojanovic, C., E 12185 Thompson, C. M., A 12758 Stoker, J. H., E 12748 Thompson, H. K., Jr., A 10638 Stokes, J., E 12553, E 12554 Taira, N., A 10331, A 10967 Thompson, J. H., A 10561, A 11808 (see also Stokes, J., III.) Takagi, H., A 10556 Thompson, J. N., A 12342 Stokes, J., III., E 10643, Takagi, M., F 11057 Thomsen, B., E 10514 E 10878, (see also Stokes, J.) Taken°, K., C 10419 Thomson, M. L., D 10775, D 11132 Stokinger, H. E., A 11485 Takayama, S., A 10398, A 12108, Thong-Yai, K., D 12093 Stoll, B., J 12516 A 12156, A 12700 Thorarinsson, H., B 12394 Stone, D. D., C 12269 Takenouchi, S., D 10685 Thorne, M. C., E 12137 Stone, R. W., D 10596 Takeuchi, T., C 10188 Thornton, R. E., A 11228 Stout, A. P., A 12595, D 10220 Tale, P., C 11087 Thorp, D., J 10790 Stout, C., E 12147, E 12397 Talamo, R. C., D 12101 Thorslund, T. W., C 10404 Strange, E. D., A 12048 Talbert, C. R., Jr., E 10257 Thurlbeck, W. M., D 10590, D 12094, Straser, T., E 12185 Talukder, C., A 12382 D 12098 Straube, C., F 11861 Maid, A., A 12166, A 12287, Thust, R., A 11366 Strehlow, C., D 12703 A 12363 Thyresson, N., F 12198 Strieder, D. J., D 11231 Tamaki, E., A 11175 Thysell, R., E 10248 Strobel, M., 8 10844 Tan, B. H., F 12158 Tibblin, C., D 10512, D 12231, Strong, J. P., E 10770, E 12145 Tanabe, T., C 10419 E 10943, E 11055, E 11634, Stubbs, 7., E 11821 Tanaka, S., A 10062, % 11476, J 12821 Stubna, J., B 12511 A 11471, A 11479 Tibbling, L., A 12270 Stucchi, C. F., F 11469 Taner, E., A 11181 Tibor, B., A 12380 Stucki, D., F 10621 Tannenbaum, P. H., J 10659 Ticsa, I., A 12396 Stucki, P., E 11092 Tansurat, P., B 12165 Tierney, J. T., J 11994, K 10283 Stukomis, M., B 11334 Taper, H. S., C 11731 Tiggelbeck, D., A 10238, A 11200 Sturgill, B. C., C 12269 Tappeiner, J., C 11592 Tighe, C., B 11407 Sturgis, K. R., C 12014 Taricco, A., C 11984 Ting, N., E 12350 Stutman, 0., A 10441, A 12297, Tarnowski, C. S., A 12023 Tinker, C. M., D 10722 A 12385, A 12470 Tarsitani, F., D 11442 Titscher, R., C 11965 Sugai, T., A 12713 Tarter, R., E 10537 TjaIve, H., A 11148 Sugimura, T., A 10931 Tarusov, B. N., A 10197, A 12701 Tjavokin, W. W., E 10697 Sugiura, K., A 10396 Tashbekov, B. U., A 12818, E 11831 Tkocheva, C. A., A 11468 Taylor, D. J., A 12310 Toblasch, V., J 12215

327 3$7 Todd, J. K,, A 12328 Urosevic, P., A 11188, A 11190 Vercellotti, E., J 11935, Toiler, 0. B., E 11794 U.S. Department of Health, J 12126. J 12127 Taker, R. L., A 12182 Education, and Welfare. Public Verhulst, H. L., A 11256 Toki, K., E 11417 Health Service. A 12535. Vermund, H., C 10466 Tokin, B. F., A 11152 B 12148, 8 12477, C 10298, Verachuuren, H. C., A 10901 Tokuhata, G. K., F 11603 C 10356, C 10402. D 12054, Vesely. K. T., F 11513 Talker, E. B., A 11130, D 11105 D 12075, D 12840. E 11880. Vesselinovitch, D., E 10784. (see Taman, R., B 11450 F 11899. J 10383. J 10463, also Vesselinovitch, S. D.) Tomatis, L., A 10895, A 11073 J 10502, J 11011, J 11319. Vesselinovitch, 5. D., A 10399, Tomln, 14., A 11188, A 11190 J 11320 A 11135, (see also Vesselinovitch, Tomkins, S., C 10667 U.S. Department of Health, D.) Toren, M., D 11673 Education, and Welfare. Public Vessey, M. P., E 11561, E 12650 Torre, E., F 11761 Health Service. National Vestri, A., E 11542 Toth, 8., A 12024 Clearinghouse for Smoking and Veys, C. A., A 11225, C 12107 Touraine, R., C 10704 Health. J 11568, J 11680 Viczian, M., A 11956, A 12811, Toutatn, D., A 11353 U.S. Federal Trade Commission, F 11263 Toyama, T., D 11797 I 10581, I 11689, J 11687, Vidal, J., C 11963 Trahair, R. C. S., K 10562 J 11688 Vigilant, E. C., C 10698 Tran, M. H., A 11782 U.S. House of Representatives, Villano, R., D 12070 Treger, A., A 10239 91st Congress, 1st Session, Vincent, N. J., D 11684 Trethevie, E. R., A 10577 I 11396, I 11397, I 11398, Vincent, R., F 11629, (see Trible, W. M., C 11091, C 12235 1 11399 also Vincent, R. G.) idol°, V. A., A 10332 U.S. Senate, 91st Congress. Vincent, R. G., A 12242, (see Troll, W., A 10712, A 11892 1st Session, 1 12838, 1 12839 also Vincent, R.) Trompeo, C., A 12512 Utomiya, J., A 11735 Violent., A., A 11360 Truhaut, R., A 11353 Uts, G., D 11590 Vies, R. 0., E 12403 Tsartsidte, M. A., A 10197, Vodraske, R., J 10766, J 12814 A 12701 Voile, R. L., A 11882 Ta'o, P. 0. P., A 10617, A 11496 Volm, M., A 11007 Teo, T. C., A 10223, A 10232, von Baumgarten. A. M., A 10378 A 10233, A 11012 von Essen, C. F., 8 10465, Tsuji, T., A 12713 C 11724, C 11791 Tsukushi, S., C 11267 Vacek, N., E 10767 Vormaland, 0., J 10948 Myna., R., A 11071 Vachon, J., E 11830 Voronkova, A. V., D 10817 Tuaillon, J., D 10475 Vadura, F., C 10939 Vorontsov, N. I., D 10817 Tuck Barcelo, L., C 12597 vahleusiack, W., C 10473 Vorverk, A., A 12053 Tuchmann-Duplessis, N., F 10403 Valadaud, D., A 11973 Voss, E., F 11958 Tucker, D. L., C 10713 Valaitis, J., C 10763 Vrcelj, S., F 10800 Tully, G. W., A 10634 Valentine, C., A 11228 Vyas, B. K., B 12753 Turbiner, S., A 11497, A 12528 Valentin'. S. 8., C 10524 Turino. G. H., D 12064 Valgma, K. A.. E 12710 Turkevich, N. M., A 12468 van Dellen, T. R., E 11439 Turner, W. A., D 10563 Vandenbrouck, C., C 11539 Turpeinen, 0., E 12244 van der Sands. D., E 10514 Turusov, V. S., A 10203, van der Slikke, G. J., E 10379 A 12514. A 12817 van der Val. A. M., C 10702 Waardenburg, H. A. J., D 12441 Trainees'. D. S., Jr.. D 10551 van de Woestijne, K. P., D 11673. Wade, 0. L., B 12680 D 12688 Wadhvani, B., D 12275 van Duuren, B. L., A 10228, Waerhaug, J., J 10578 A 10303, A 10333. A 10352, Wagenknecht, L. V., C 11769 A 10712, A 10962, A 11192, Wagner, M. K., K 10516, K 10519 A 12122, A 12712 Valhi. P. N., A 11616 Vanini, G. C., A 12512. J 11935 Wahl, P.. E 10846, E 12205 Udell. J. A., K 11258 vsAaJulsinghs. J., A 12184 Walng*4, F., J 10215 Uehleke, H., A 12360 van Metre, T. E., Jr.. D 12168 Wainvrighz, J., E 11160 Uhl. C., C 1'199, C 12212 van Mien, P. J., C 11603 Wake, P. R., J 10391, K 10507 Ul'anov, A. V., A 11208 VIA Pr000dij, C., A 12202, E 12191 Wakefield. J., G 11685 nett. J. A., 1' 11490 von Rootselaar, F. J., C 12226 Wakeham, H., A 10372. A 11210, (see Ulmer, W. T., C 10637 van wayenbeeg. J., D 11673 also Waltham. H. 1. R.) Liman., R. S., 4 10617, A 11496 Varga, G., C 12810 Wakeham, H. R. R., J 12429, (see Ungar, D., P 11221 Vargha, O., D 11268, D 11593 also Wakeham. H.) United States ... (see U.S. ...) Vatter, A. E., D 12068 Walaszek, E. J., A 10490 University of Arizona, Center Vosirani, S. J., C 12768 Waldsann, D., E 11466 for Research on Smoking and Veeze, P., C 11763 Watford, J., D 11624 Health, J 12141 Veldman, D. J., J 10599 Walike, J. W., C 10881 University of Natal. Department Vellar, 0. D., J 11045 Walker, A. B. P., E 11638, E 12161, of Hat aology, J 12587 Venable, C. S., J 10711 E 12717

326 33 2. Walker. K., C 12260, D 11481 Weiser, J. R., A 10464 Wissier, R. W., E 10784 Walker, R. E., J 10486 Wendekamm, R., D 11941, K 10413. Witt, J.-P., C 10541, C 11865 Walker, S. H., D 11157 K 11852 Woeber, Kh., 1312189, J 12217 Walker, W. C., D 11652 Wender, S. H., A 11787 Wohlford, P., J 12422 Wall, H. E., A 12310 Wenyon, E. N., A 10895 WoJnar, V. S., E 12526 Wallace. W. F. H., B 12680 Wepeic, H. T., A 12378, A 12379 Wolf, H., C 11769 Waller, S. L., A 11149 Werle, E., A 10832, A 10872 Wolf, J., B 12133 Wallis, V., A 12655 Werner, T., B 12189, J 12217 Wolfe, J. 11.,13 11407 Walter, D. C., C 12677 Werner, U., D 10637 Wolfe, W. G., D 12074 Walters. N. A., A 12652 Wernssan, E. A., A 12697 Wolff, X., C 11592 Walton, R. A., D 10551 Weedier, S., E 11674 Wolfort, F. C., C 10773 Welts, P., A 11212 West, J. B., D 12063 Wolfson, P., D 12703 Wandrey, K., A 11186 Westbrook, J. J., A 11209 Wolfson, R. L., 0 11992 Wanebo, C. K., C 10404 Weston. B. J., A 11571, A '2654 Wolinsky, H,, C 11608, C 12239 Warbrick-Smith, D., A 12639 Weswig, P. H., F 12271 Woltz, W. G., A 11185 Waring. G., J 11343 Verdi. K., C 12648, C 12649 Wong, S., A 10966 Vernal, D. A., D 11251, Wey, W., C 10849 Wood, B. T., F 11796 D 12030 Weybrev, B. B., F 10924 Wood, D. A., C 12831 Warwick, G. P., A 12569, Veybrew, J. A., A 11185 Wood, H., A 11114, A 11156, F 11247 Whang-Peng, J., A 12378 A 12583 Warwick, K. M., A 12326 Wheatley, D. N.. A 10629, Woodcock, S. R., A 11986 Washington University School of A 10900, A 12494 Woods, D. A., A 10774, A 12461 Medicine, Department of Wheeler, W. L., Jr.. C 11980 Woolcock, A. 3., A 12089, D 11684 Medicine, St. Louis, Hissouci, Whitaker, W., E 10769 Woolf, N., A 10553 E 12154 White. C., J 12373 Woolner, L. B., C 10424 Wasserman, A. J., B 10369 White, P. D., E 10570 World Health Organization, 8 11602, Wasiak, H., A 10583 Whitehead, J. K., A 12750 C 12589, E 12302, E 12383, Waterman, D. H.. D 11409 Whiter, H. H., E 10570 E 12728, F 10923 Waters, V. g., B 11877 Whitman, T. L., K 12387 Worth, G., D 10730 Watkins. R. S., E 10257 Whittinghen, S., F 11221 Worth, R. M., D 11618 Watne, A. 1., C 10863 Wichern, H., A 10952, A 10953, Wosivodtki, H., A 10949 Watson. J., A 11130 A 11204 Wright, E. C., A 12667 Watson, W. L., B 11394, Widmer. L. K., E 11546 Wright. F. E., 0 12778 C 11388, C 11390. C 11392, Wiebecke, B., A 11733 Wright. G. W., D 10591 C 12765, C 12769, C 12776, Wightnan, J. A. K., D 12414 Wright, V., D 11652 C 12782, C 12784, C 12785, Wilde, W., 0 11959 Wstep, I., A 12196 C 12786, C 12791. C 12792 Wildner, G. P., B 11774, C 10930 Wu, C.-C., E 11381 Watson-Williams, B. J., F 12153 Wilhelmmen, L., D 12231, J 12821, Wunder, R., C 10909 Wattenberg, L. W., A 10442, K 10782 wundobl, F. F., 0 10554 A 12266 Wilk, C., C 12834 Whet, H., F 12208 Waynforth, H. B., A 12577 Wilkes, E., J 11622 Wyatt, J. P., D 10776, D 12092 Weary. P. E., 17 11796 Wilkins, G. W., C 10773 Wynder, E. L., A 10227, A 10353. Weathers. D. R., p 10918 Wilkinson, P., D 11301 A 10585, A 11589, A 11723, Weber, K. N., A 10859 Willa, C., C 11968 A 12123, A 12124. C 10693, Webster, J. R., Jr., D 10348 Williams, A. 0., F 10916 C 11389, C 12416, J 10211 Wechsler, V., A 12306 Williams, H. 0., C 12019, K 11507 Wyndham, C. H., E 11821 Wehner, A. P., A 11474 Williams, J. B., D 10716, D 12797 Wye:yrs-Ica, H., A 12376 Wehrle, P. 9., J 12718 Williams, J. F., A 10543 Weigensterg, 1. J., C 10813 Williams, K., A 12653 Weill, H., V 11347 Williams, M. H., Jr., C 11608 Weinblatt, E., E 11382 Williams, M. K., D 11624 Weiner, B. P., D 11618 Williams, R. E., C 12272 Weiner. J. M., E 10612 Williams, R. G., A 11986 Weinbouse, S., A 11795, A 12463 Williansoo, J. T,, A 11211 Tebtokov, D. D., D 11851 Weir, J. M., A 10584, I 10515, Wilson, J., A 12532, F 10890. (see Tafte, S. J., A 12300 C 11566 also Wilson, N. JO Tagi, M., C 11009 Weiss, W., C 11668, D 10444, N. J., A 12089, (see also Yamada. N., C 10188 F 12561, J 12370 Wilson, J.) Yamada, S., A 10310. A 10311, Weisemann, G., A 10712 Wilson, R. B., E 11457 A 10312, A 10311, A 10114, Veltman, H., J 10666 Wilson. T. H., F 11822, F 12419 A 10315 Welborn, T. A., D 11294, 6 11597 Winefordner, J. D., A 10937 Yamegate, S., A 10411 Welch, R. M., A 10177 Wing, A. L., E 12117, F 12136 Yamaguchi, H., A 12439 Welln, G., E 11614 Winkelstein, W., Jr., D 10960 Taassuchi, Y., E 10198 Wellsann, X. F., C 10925 Winkelvose, E., K 10413, K 11852 Tamcsaws, S., A 10492 Wells, A. B., A 12573 Winker, J., F 12486 Yamashita, A., A 11530 Wells, R., 8 12243 Winton. J., 1 11407 Tasstaki, J. N.. J 12718 Waled,. C. W., A 11001, A 12311 Wisniowsks, J., C 11051

329 355 Yanagava, H., D 11792 Zvarich, T. A., 10206 yanagerva, N., D 12440 Zylak, C., D 12092 Yana!, R.. A 10932 Zyzandski, 5. J., E 10261 yano, 3 A 12401 yerygins, V. Ya., D 10817 Yasuhira, K., A 10567 Yeager, H., Jr., A 11424 Yin, 5 D 12077 Yoshiba, A., C 11267 Yoshida, H., A 10362, A 11476, A 11479 Yoshida, K., A 11530, A 12166, A 12363 Yoshida, 0., C 10309 Yoshida, T., A 12135, (see also Yoshida, T. 0.) yga, T. 0., A 10354, (see also Yoshida, T.) Yoshikawa, K., A 11530 Yoshimura, S., E 11923 Yoshisakt, H., E 10878 Yosida, T. H., A 11071 Younostat, E. K.,F11898 Youth Advisory Council Smoking & Health Committee, J 11579 Yuhara, K., A 10940 Yunia, E.J.,A 10441, A 12297, A12385

Zacthe, E., E 11278 Zacharta, T. P., A 12256 Zacho,A.,C 12591 Zackler, J., F 11395 Zagona, 5. V., 0 10671, J 10394, J 12725 Zaka, 2. M., 8 11407 Unfit, Gh., C 12224 Zanotellt, F., C 10324 Zapletal, A., D 11682 Zapletal, J., C 11962 Zaaypka, A. T., A 12815 Zbar, B., A 12378, A 12379 Zderkiev5cs, H., B 10316 Zegerellt, E. V., C 22252, C 12177 Zeiesr-Henriksen, T., E 12190 Zhichina, A. I., D 10817 Ziccardl, J. V., A11640 Zickgraf, Th., C 10852 Zielhuis, R. L., C 11838 Ztelke, N. R., A 10350, A 12594 Zielonka, B., A 12028 211siyan, V. H., A 10469 Zismerman, H. H.,A12388 Zimmermann, F. K., A 10876 liskind, H., D 11347 Zorbalas, D. I., A 11266 Zutehatto, C., B 10426 Zulth, K. J., A 12306, A 12457 Zuskin, E., D 11992 Zussman, B. H.,F10995

130 334 SUBJECT INDEX

ACADEMIC ACHIEVEMENT, E 10484 ADVERTISING (Cont'd) AIR POLLUTION (Cont'd) smokers vs. nonsmokers, health warnings in, I, 10860, effect on mucociliary activity, J 10599 1 11333, I 11455, 1 11625, D 10717, D 10725 1 12291, I 12836, J 10387, effect on mucous membrane, ACCIDENTS J 10689, J 12755 C 11357, D 11672 (see also FIRES.) labeling and, A 11052, I 10564, effect on respiratory tract, personality as a factor, I 10581, I 11119, I 11233, A 10781, B 11144, B 11269, F 10433, F 12136 I 11333, I 11396, I 11400, D 10960 smoking and, P 12136 I 11455, J 10387, J 11096, effect on smokers, 8 11480, smoking as cause, A 10364, J 11687 C 10700. D 10247, D 10776, F 10433, P 10517 legislation, I 11322, 1 11488, D 10960, D 11341, P 12417 I 12836, 1 12839 in lung neoplasm etiology, ACETALDEHYDE mass media and, 1 11322, I 11333, C 11357, C 12648, C 12649 (see also ALDEHYDES.) I 11396, I 11400, I 11447, lung neoplasms and, C 11875 effect on ciliary activity, I 11455, I 11514, I 12116, in neoplasm etiology, A 10572 A 10474 I 12738, J 11321, J 11332, respiratory tract diseases and, effect on histamine levels, J 11335 C 12265, D 10690, D 10779, A 10323, A 10544 prohibition, I 10478, I 10650, D 11797 I 10956, I 10975, 1 11119, smoking and, C 12648, C 12649. ACROLEIN 1 11447, I 11587, 1 11648, E 11952 (see also ALDEHYDES.) 1 11701, I 11702, 1 11703, unstable species in, C 11041, in cigarette smoke, A 10323, I 11704, I 11705, I 11706, C 11585, F 11047 A 12453 1 11707, I 11708, I 11709, affect on ciliary activity, I 11710, I 11711, I 11714, ALCOHOL CONSUMPTION, A 11256, A 10474 I 11717, I 11721, I 12738, E 12200, E 12447 effect on histamine levels, I 12839, J 10649, J 10893, effect on morbidity, F 11900 A 10323, A 10544 J 11096, J 11111, J 11117, effect on neonate, A 11262 J 11118, J 11332, J 11551, effect on smokers, D 11301 ADENOCARCINOMA J 11649, J 11650 in mouth neoplasm etiology, (see also CARCINOMA; NEOPLASMS) regulation of, B 11844, C 11691 C 11402, C 12692 case history, C 10692 I 10975, 1 10989, I 11119, smoking and, A 12013, 8 11450, diagnosis, C 10501, C 10692, I 11233, 1 11396, I 11397, C 11402, C 11989, C 12033, C 10917, C 11391, C 12239, I 11398, I 11399, I 11400, C 12375, C 12416, C 12452, C 12810 1 11447, I 11455. I 11625, C 12692, E 11575. E 11591, in laboratory animals, A 12657 I 11689, I 11714, I 11717, 1 11794, E 12021, E 12251, met.ltasis of, C 10925 1 11718, I 12838, J 10659, F 11221, F 11469, F 11926, prognosis, C 12128 J 10689, J 10893, J 10990, 12136, F 12415, C 12757, smoking and, C 10501, C 10917, J 11342, J 11687, J 11688 J 11277, J 11384, J 12126, C 11391 in United States, I 11648 J 12151, J 12755 therapy, C 11391, C 12128 AIR POLLUTION ALCOHOLS ADRENAL CORTEX HORMONES bronchitis and, D 10960 leterminetton in tobacco, A 11187 effect of acetylcholine, chronic broncbopulmonary A 10423, A 10429 d ard, D 10978 ALDEHYDES effect of cigarette smoke, (see also ACETALDEHYDE; ACROLEIN.) ADRENAL CORTEX NEOPLASMS A 11372. J 12351 in cigarette smoke, A 10323, experimentally induced, A 11800 effect of smoking, A 10191, A 10544, A 11207, A 11208 pathogenesis, C 11261 A 12731, II 11407, D 10690, determination in tobacco, A 11187 3 12493 ADVERTISING effect on cardiovascular ALIPHATIC HYDROCARBONS antismoking campaigns and, system, A 11485, B 11144 carcinogenicity, A 12698 1 10581, 1 11239, J 10387, effect on morbidity, B 10267, determination in cigarette smoke, J 11343, J 11522 B 11480, B 11901, D 11341, A 11202, A 11207, A 11208 in Canada, J 11649, J 11650 7 11047 in tobacco leaf, A 11187 cigarette sales and, I 11689 effect on mortality, B 10267, effect on smoking habit, B 11144, B 11480, B 11901, ALKALOID CONTENT J 10659, J 10689, J 11687 D 11341 (see also NICOTINE CONTENT; health warnings is, A 11052 NORNICOTINE CONTENT.) 1 10409, 1 10564, 1 10581,

331 3.35" ALKALOID CONTENT (Cont'd) o-AMINOPHENOLS (Cont'd) ANTISMOKING CAMPAIGNS (Cont'd) in cigarette smoke, A 11161, as tryptophan metabolites, cigarette sales and, H 10241, A 11201 C 10605, C 10606 J 10282, J 10565, J 10644, in cigar smoke, A 11201 J 10703, J 10786, J 10877, determination in. tobacco, ANGINA PECTORIS J 10920, J 11296, J 11327 A 10937 (see also CORONARY DISEASE.) effect on smoking habit, 1 12173 determination in tobacco leaf, diagnosis, E 11832, E 12044, evaluation, C 10668, C 10669, A 11403 E 12221 C 11887, H 10241, J 10265, determination in tobacco smoke, predisposing factors, E 10204, J 10300, J 10340, J 10341, A 11204 10304, E 10874, E 10991, J 10405, 3 10644, J 10645, effect of fertilizers, A 11162, E 11382, E 11442, E 11983 J 10658, J 10670, J 10745, A 11171 prognosis, E 11254 3 10759, 3 10761, 3 10190, effect of moisture, A 11164 smoking and, 0 11729, D 11798, J 11292, J 11296, J 11344, effect of viral infection, E 10217, E 10261, E 10369, J 11551, J 11562, J 11643, A 11180 E 10874, E 10943, E 11055. J 11644, J 11664, J 11764, in tobacco leaf, A 11161, E 11382, E 11442, E 11463, J 12843, J 12844, J 12845 A 11180, A 11181 E 11559, E 11574, E 11657, fear in, J 10300, J 10421, tobacco variety and, A 12764 E 12154, E 12228, E 12552 J 11292, J 11308, J 11565 smoking as cause. E 11042, follow-up studies, J 10764, ALKALOID METABOLISM E 12225 J 11664 (see also NICOTINE METABOLISM.) stress and, E 11414 in Germany, C 12505, J 12215 biosynthesis in tobacco. therapy, D 11729, E 10304, health warnings in, A 10832, A 11170 E 11054, E 11442, E 11574, J 10241, I 10409, I 10749, E 11825, E 11832, E 11929, J 10287, J 10383, J 10530, ALKALOIDS, TOBACCO E 12041, E 12044, E 12154, J 10703, J 10740, J 10746, (see also COTININE; HETEROCYCLIC E 12221, E 12225 J 10920, J 11317. J 11343, NITROGEN COMPOUNDS; NICOTINE.) J 12631 analysis, A 11186 ANTISMOKING CAMPAIGNS in Holland, C 11748 determination in tobacco advertising and, A 10832, in hospitals, J 11670. J 12844 leaf, A 11403, A 12696, D 11518, 1 10409, I 10478, in Hungary, J 12802, J 12804, A 12697 I 10956, I 10975, I 11119, 12812 pyrolysis products, A 11204 1 11333, I 11400, 1 11447, in Indiana, .1 10825 tobacco variety and, A 11012, I 11702, I 11709, I 12738, in Iowa. J 12352 A 11170, A 11180 J 10340, J 10662, J 10703, in Ireland, J 11111 J 10920, J 11096, J 11111, in Italy, J 11841 47831.T0PIA, TOBACCO J 11159, J 11332, J 11342, labeling and, J 11562 (see also EYE DISEASES.) J 11609, J 12755 legislation, I 10809, I 10975, cyanides and, F 11261 age as a factor, C 12505, 3 10649, J 10662, J 10893, diagnosis, F 10318 I 10809, 1 11704, J 10265, 3 11418, 3 11551, 3 12754 effect of vitamins, F 10318, J 10276, J 10341, J 10463, mass media and, 1 10989, 1 11119, F 10768, F 11822, F 12153 J 10509, J 10530, J 10727, I 11233, J 11111, J 11159, metabolic disorders in, F 11822 J 10764, J 10929, J 11086, J 11321, J 11332, J 11344, smoking and, F 10318, F 10768, J 11317, J 11321, J 11324, J 12481 F 10856, F 11926, F 12153, J 11326, J 11329, J 11330, methods, C 10664, C 10672, F 12286, F 12419 J 11331, J 11744, J 11643. C 11685, I 11704, 1 11717. therapy, F 10318, F 10768, J 12284, J 12169,.1 12718, 3 10276, J 10300, .110340, F 11926, F 12419 J 12801, J12814 J 10341, J 10405, J 10622, audio-visualaids, J 10287, J 10645, J 10658, J 10662, AMINES J 10300, J10383, J 10502, J 10666. J 10681, J 10703, (see also AMINO ACIDS.) J 10645, J10904, J 11062, J 10709, J 10740, J 10741, determination in tobacco, J 11086, J11103, J 11104, J 10745, J 10759, J 10761, A 11186 J 11319, J1)320, J 12370, J 10764, J 10788, J 10790, determination in tobacco smoke, K 10516 J 10792, 3 11292, 3 11308, A 11204, A 12356 in Australia, J 11380, J 11641, J 11330, J 113)1, 3 11418, J 11895 J 11551, J 11557, J 11562, AMINO ACIDS In California, J 11557 J 11565, J 11609, J 11664, (see also AMINES; CARBOXYLIC in Canada, A 12443, I10479, J 11734, J 11755, J 11806, ACIDS.) I 11700, I 11701, I11702, J 11841, J 11895, J 12370, pyrolysis products, A 10587 I11703, 1 11104, I11705, 3 12629, 3 12718, 3 12143, 1 11706, I11707, I11708, 12844, J 12845 o-AM1NOPNENOLS 111709, I11710, I11711, in Michigan, I 10478 (see also PHENOLS.) 1 11712, I11713, 111714, in New Jersey, J 11296 carcniinicity, C 10560, 111715, I12285, J10649, in Norway, C 10948, J 11326, C 10606 J11096, 311292, J11343, J 11332 J12754

332 134 ANTISMOKING CAMPAIGNS (Cont'd) ANTISMOKING CAMPAIGNS (Cont'd) AROMATIC AMINES (Coned) occupation as a factor, J 10459, in Scotland, J 10741 effect on RNA, A 12828 in Ohio, J 10790 in Sweden, J 12442 formation in amino acid Parent Teacher Associations in, in United Kingdom, B 11074, pyrolysis, A 10353 J 10497, J 10814 10809, J 10806, J 11086, in liver neoplasm induction, in Pennsylvania, J 10497, J 11138, J 11325, 3 11522. A 12108, A 12463, A 12566, J 10788, J 10929, J 12369 J 11609, J 11643 A 12601 public education and, 1 10409, in United States, 1 10956, metabolism, A 12360, A 12540, J 104.21, J 10806, J 10929, I 11322, 1 11333, I 11709, A 12828 J 11138, J 11292, J 11321, J 10745, J 10792, J 10920, metabolites, A 11892, A 11893, J 11325 J 11159, J 11327, J 11522, A 12828 research programs, G 10664, J 11647, J 11670 in neoplasm induction, A 12.49, J 10622, J 10662, J 11326, C 12647 J 11328, J 11329 ANTISMOKING MATERIALS in Rhode Island, J 11487 audio-visual aids, A 12535, AROMATIC HYDROCARBONS role of community leaders, J 10383, 3 10502, J 10681, (see also BENZ(a)ANTHRACENES; J 11106, J 12625, J 12631 J 10711, J 10819, J 10904, BENZO(a)PYRENE; BENZO(e)PYRENE; role of dentists, B 10515, J 11062, J 11086, J 11103, CHRYSENES; DIBENZ(a,h)- C 11142, C 11566, J 10647, J 11104, J 11159, J 11319, ANTHRACENE; DIBENZ0(a,1)- J 10709, J 11647 J 11320, K 10516 PYRFNE.) role of government, G 10668, evaluation, J 10681 in air pollution, A 10191, G 11685, 1 10661, I 11580, in schools, J 10502, J 10666 A 10572, A 12376, A 12512, 1 11714, I 11717, J 10649, C 12648, C 12649 .1 10662, J 10920, J 10929, ANTITUMOR AGENT, A 11530, A 11613, analysis, A 11500, A 12427, J 11562, J 11636, J 11664, A 11614 A 12437, A 12454, A 12750 J 11670, J 11690 toxicity, A 11801 in brain neoplasm induction, role of health educators, A 12388 J 10530 ARECA CHEWING carcinogenicity, A 10303, role of medical personnel, (see also ARECOL1VE; TOBACCO A 10333, A 10567, A 10585, D 10555, J 10282, J 10509, CHEWING.) A 11097, A 11284, A 12135, J 10786, J 10904, J 11103, effect on mucous membrane, A 12382, A 12427, A 12490, J 11104 C 11252, C 11724 A 12694, A 12837 role of parents, J 11504, in mouth disease etiology, J 10578 as cause of lung neoplasms, J 12370 mouth diseases and, C 10443 A 12131 role of physicians, B 10270, in mouth neoplasm etiology, in cigarette smoke, A 11203, B 12621. C 12169, F 10768, C 10713 A 11500, A 12750 G 11691, I 10956, 1 11233, mouth neoplasms and, C 10443, determination, A 10587 1 11239, I 11447, 1 11623, C 11724 determination in sir, A 12512 J 10244, J 10264, J 10276, determination iu cigarette smoke, J 10282, J 10296, J 10349, ARECOLINC A 11280, A 12046 J 10421, J 10539, J 10565, (see also ARECA CHEWING.) effect of irradiation, A 12700, J 10569, J 10571, J 10602, effect on acetylcholine A 12745 J 10658, J 10727, J 10746, pharmacology, A 10957 effect on cells, A 10197, A 10367, J 19790, J 10814, J 10819, A 12382, A 12562, A 12576, J 10825, J 10877, J 10955, AROMATIC AMINES A 12700, A 12701 J 10982, J 10990, J 11096, analysis, A 12437 effect at DNA, A 10367, A 10876, J 11100, J 11117, J 11118, in bladder neoplasm etiology, A 11967, A 12405, A 12562, J 11235, J 11444, J 11637, C 11225 A 12565, A 12745 J 11664, J 11670, J 12230, in bladder neoplasm induction, effect on enzyme activity, J 12364, J 12442, J 12518, A .2400 A 10194, A 10255, A 11102, J 12629, J 12801, J 12802, bladder neoplasms and, A 11892, A 12463 J 12803, J 12804, J 12844, A 11893 effect on hydroxylase activity, 11507 carcinogenicity, A 11023, A 11114, A 11025, A 11171, A 12300, in schools, C 12820, G 10664, A 11282, A 11373, A 12135, A 12372, A 12602, A 12747 G 12505, 1 11719, J 10265, A 12355, A 12566, A 12583, in liver neoplasm induction, J 10341, J 10421. J 10491, A 12694, C 10278, C 10560, A 12463 J 10497, J 10502. J 10530, C 11016, C 12006, C 12103, mechanism of action, A 12565 J 10645, J 10666, J 10711, C 12104, C 12105, C 12107, metabolism, A 12562, A 12565, J 10727, J 10740, J10764, C 12393, C 12435, C 12741 A 12747 J 10788, J 11131, J11138, determination in cigarette smoke, metabolism in liver, A 11943 J 11317. J 11321, J11329, A 10353, A 10908, A 11204 toxicity, A 10572, A 12646 J 11330, J 11331, J11487, determination in tobacco, A 11186 J 12284, J 12369, J12592, determination in tobacco smoke, ARSENICALS J 12623, J 12624, J12626, A 12356 carcinogenicity, A 10839, A 11485, J 12627, J 12628, J12629 effect on cells, A 12400 A 12664 J 12630, J 12801, J12814, effect on DNA, A 12400, A 12828, toxicity, C 11860, F 11427 J 12843, K 11910 C 12105

333 337 ARSENIC CONTENT ARTERIOSCLEROSIS (Cont'd) ARTHRITIS brand ditferences, A 11406 experimentally induced, lung diseases and, D 11652 determination in tobacco leaf, E 11457, E 11743, E 11888, smoking and, D 11652 A 11406 E 11990, E 12143, E 12144, E 12145, E 12146, E 12147, ASH, CIGARETTE ARTERIAL DISEASES, E 12080, E 12238, E 12271, E 12279, polonium -210 in, F 10858 E 12082, E 12083 E 12317, E 12526 (see also ARTERIOSCLEROSIS; heredity as s factor, E 10799, ASTHMA, D 11538, D 12087, E 11414 ARTERITIS; CARDIOVASCULAR E 12110 (see also RESPIRATORY TRACT DISEASES; THROMBOANGIITIS in India, E 12115 DISEASES.) OBLITEPANS.) morbidity, B 11510, E 11923 bronchitis and, D 11699 age as a factor, E 10262, mortality, B 10601, B 11244, diagnosis, D 12168 E 11354, E 11378 E 11426, B 11434,F. 11160, effect on lung function, D 11684 diagnosis, E 11354, E 11862, E 11923, E 12031, E 12507, morbidity, B 11449, B 12511 E 12039, E 12209 E 12728, E 12799 mortality, B 11511 experimentally induced, E 12060 nicotine and, E 10460, E 10846, occupation as a factor, A 11050, nicotine ard, E 11732 E 11286 8 11511, D 10470, 0 11470, pathogenesis, E 11862 occupation as a factor, F 10548 predisposing factors, E 11732 E 10422, E 10432, E 10514 pathogenesis, D 10705, D 10817 smoking and, E 10262, E 10308, pathogenesis, A 10765, D 10817, pesticide residues and, D 11618 E 10848, E 10887, E 11241, E 10263, C 10655, E 10707, predisposing factors, B 12530, E 11546, E 11732, E 11867, E 10784, E lor13, E 11120, D 10705, D 11364, D 11851 E 11944, E 12039, E 11246, E 11439, E 1,754, E 11888, smoking and, D 10705, D 11132, 12523 E 11923, E 11949,E. 12042, D 11364, D 11464, D 12434, smoking as cause, E 11862, E 12271, E 12276, E 12332, F 10995 I 11711 E 12383 therapy, D 11251, D 11404, smoking in etiology of, predisposing factors, E 10263, D 11464, D 12088, D 12390 E 11054,F. 11354 E 10286, E 10304, E 10322, therapy, C 11969, E10300, E 10400, E 10422, E 10432, ATROPINE E 10737, E 10887,E 10906, E 10526, E 10656, E 10707, effect on autonomic nervous E 11094, E 11354,E 11517, E 10922, E 11314, E 11546, system, A 10423, A 10429, E 11859, E 11867,E 11933, E 11743, E 11773, E 11814, A 12615 E 11944, E 12039,E 12209, 5 12042, E 12043,68. 12445 E 12732 preventive medicine, B 12504, ATTITUDES E 10410, E 11345, E 11381, (see also BEHAVIOR.) ARTERIOSCLEROSIS E 11430, E 11816, E 12213, smokers, C 12714 (see also ARTERIAL DISEASES; 2 12294, E 12362 E 12480 smokers vs. nonsmokers, J 10599, CORONARY DISEASE.) race as a factor, E 11408, J 12845 age as a factor, E 10262, E 11923, F 10916 E 10368, E 10514, E 10537, sex as a factor, E 115'5, E 12462 AVOIDANCE LEARNING 10707, E 10804, E 10886, smoking and, D 10919, E 10217, (see also LEARNING.) E 11378, E 11408, E 11575, E 10262, E 10304, E 10322, in cessation of smoking, K 10307 8 11921, E 12462 10368, E 10400, E 10422, carbon monoxide in etiology of, E 10432, E 10451, E 10514, 1: 11657 E 10526, E 10537, E 10824, diagnosis, E 10322, E 10824, E 10645, 1 10886, E 10887, E 11316, 11537, E 11949, E 10922, E 11058, E 11241, E 12038 E 11546, E 11575, E 11591, diet and, A 12155, E 10770, E 11657, E 12C:1, E 12038, BEHAVIOR 8 10784, E 10959, E 11417, E 12042, E 11041, E 12147, (see also ATTITUDES; PERSONALITY; 11457, E 11812, E 11816, E 12238, E 12491, L 12552, SMOKING CHARACTERISTICS.) E 11921, 8 120U1, E 12143, E 22608, F 11000, J 12215 effect of fear, C 12714, J 10421 E 12144, E 12145, E 12146, smokn5 in etiology of, E 10846 effect of nicotine, A 12702, E 12147, C 12277, E 12279, stress and, E 11990, E 12317 C 10588, C 11121, C 11122, E 12294, E 12317, 8 12362, in Taiwan, r 11058 C 11348, C 11484, C 12548, E 12403, E 1243.0, E 1743 therapy, E 10369, E 1088'. C 12149 epidemiology, t 10656, E 11734. E 11417, E 11457, E 11531', effect of smoking, A 10583, 1: 12213, E 12362 E 11754, E 12038, E 12041, A 11137, G 11072 etiology, E 10432, E 10460, E 12043, E 12213, E 12222 research programs, C 12842 E 10603, E 10604, E 11058, thromboangiitis obliterars and, smokers vs. nonsmokers, A 12326, 8 11591, F. 11921, E 12276. E 10308, E 10887 F 10924, C 11698, C 12715 E 12277, E 12132 smoking habit and, A 11829, experimentally induced. A 12396, ARTERITIS C 10632, C 10798,C 11070, E 10697, E 10770, E 10784, (see also MiR/AL DISEASES.) C 12714, C 12842,J 10421, E 10959, E 10970, E 11120, smoking aid, E 11571, E 118:0 J 12498, K 10382,K 10504, E 11286, E 11381, 111417, therapy, E 11571, E11630

336 335 BEILAVIOR (Coned) BENE(a)ANTHRACENES (Coned) BENZ(a)ANTHRACCHES (Coned) smoking habit and, K 10516, effect on enzyme activity, in neoplasm induction, A 11018, K 10519, K 11412, K 11495, A 11535, A 11616, A 11768, A 11069, A 11076, A 11339, K 12610 A 11463 A 11366, A 11614, A 11630, effect an fertility, A 12464, A 12012, A 12022, A 12024, BENZ(a)ANTHRACLIIE PHARMACOLOGY, A 12586 A 12109, A 12193, A 12257, A 11134, A 11139, A 11491, effect on gingiva, A 12744 A 12259, A 12470, A 12572, A 12227, A 12690 effect on hormones, A 10447, A 12580, A 12581, A 12582, effect of aromatic hydrocarbons, A 10932, A 11489 A 12674, A 12690 A 11483, A 12494 effect on hydroxylase activity, in ovarian neoplasm induction, effect of azo compounds, A 12494 A 10255, A 11025, A 11489, A 10883, A 11985, A 12337 effect of irradiation, A 11130 A 12483, A 12494 pharmacology, A 11420, A 12023, effect of 3-methylcholanthrene, effect on liver, A 10197, A 11077, A 12407 A 12651 A 12193, A 12701 in skin neoplasm induction, effect on muscles, A 12227 A 10203, A 10359, A 10396, L.N2(a)ANTHRACEVES effect on prostate, A 11068 A 104E8, A 10492, A 10531, (see also AROMATIC HYDRO- effect on RNA. A 11139, A 12484 A 10934, A 10962, A 11257, CARBONS.) effect on thymus, A 10441, A 11491, A 11535, A 11991, in adrenal cortex neoplasm A 12259, A 12464, A 12470 A 11997, A 12023, A 12124, induction, A 11800 effect on thyroid, A 11809 A 12266, A 12450, A 12484, analysis, A 12437 effect L.n tissues, A 10868, A 12672, A 12698, A 12711, in bladder neoplasm induction, A 12023, A 12514 C 11508 A 11156 effect on urogenital system, toxicity, A 10900, A 10986, carcinogenicity, A 10203, A 11257, A 12112 A 11020, A 12259, A 12267, A 10303, A 10469, A 10492, effects during pregnancy, A 11073 A 12333, A 124d3, A 12514 A 10521, A 10534, A 10862, in epidermoid carcinoma induction, A 10926, A 10936, A 10963, A 11A70 EENZO(a)PYRENE A 11020, A 11027, A 11068, in gastrointestinal neoplasm (see also AROMATIC HYDROCARBONS.) A 11136, A 12424, A 12586, induction, A 11483, A 11733, absorpti,n, F 11467 A 12663, A 12711 A 11823 in air po,lution, A 10191, carcinogenicity reduction, in liver neoplasm induction, A 10572, A 12529, E 11831 A 10629, A 11492, A 12468. A 10358, A 11077, A 11606, analysis, A 12554 A 12469 A 12463, A 12652 in brain neoplasm induction, determination in cigarette in lung neoplasm induction, A 12388 smoke, A 11203 A 11073, A 11130, A 11606, carcinogenicity, A 10303, A 10399, distribution in organs, A 12824 A 12673 A 10534. A 10706, A 10639. effect of irradiation, A 12514 in mammary neoplasm induction, A 11027, A 11068, A 12424, effect on adrena1 glands, A 10447, A 10629, A 10610, C 10219 A 10633, A 10900, A 11257, A 10868, A 20928, A 11134, carcinogenicity reduction, A 11601, A 11811, A 12261, A 11139, A 21423, A 11735, A 10269, A 10442, A 11065, A 12494, A 12563, A 12636 A 11819, A 11897, A 11914, A 11371 effect on antigen-antibody A 12000, A 12138, A 12310 as cause of lung neoplasms, A 12529 reaction, A 10354, A 11020, A 12313, A 12337, A 12464, in cigarette smoke, A 11061, A 11073, A 12571 A 12468, A 12469, A 12478, A 11500 effect on carbohydrate A 12492, A 12665, A 12719, determination, A 11472 metabolism, A 11535, A 12337 A 12720 distribution in body, A 11005, effect on cell division, mechanism of action, A 12571, A 11938 A 11136, A 12000, A 12483 A 12637 distribution in cells, A 11605 effect on cells, A 10197, metabolism, A 10355, A 11811 distribution in skin, F 11467 A 10355, A 10826, A 10868, metabolism in laboratory animals, effect of irradiation, A 12745, A 10883, A 10986, A 11020, A 10633 A 12761 A 11071, A 11077, A 11136, metabolism in liver. A 10629, effect on cell division, A 11152, A 11139, A 11257, A 11420, A 11452, A 12494, A 12636, A 1200t/ A 11601, A 11616, A 12112, A 12651 effect on cells, A 11152, A 11476, A 12171, A 12193, A 12338, metabolites, A 10629, A 10633, A 11477, A 11478, A 11479, A 12450, A 12654, A 12701, A 11452, A 12553, A 12636, A 12123, A 12382, A 12555 A 12713, F 10918 A 12651 effect on DNA, A 10617, A 10822, effect on central nervous in mouth disease induction, A 10876, A 10941, A 11353, system, A 11366 F 10918 A 11496, A 11584, A 11605, effect on DNA, A 10487, A 10876, in mouth neoplasm induction, A 11612, A 11967, A 1:^10, A 10934, A 1094), A 11139, A 10640, A 11420, A 11497, A 12405, A 12635, A 12745 A 11366, A 12483, A 12484, A 11527, A 11616, A 12171, effect on enzyme activity, A 10362, A 12564, A 12637, A 12745, A 12335, A 12407, A 12421, A 10377, A 10861, A 11353, A 12824 A 12461, A 12488, A 12528, A 11476, A 11477, A 11741, effect on enzyme activity, A 12684, A 12744 A 12102, A 12299 A 10492, A 10633, A 11139,

335 339 BENZO(a)PYRENE (Cont'd) BER0(1)PYRENE PHARMACOLOGY, BLADDER NEOPLASMS (Coat'd) effect on fetus, A 11553 A 11476, A 11477, A 11478, preventive medicine, C 10605 effect on hydroxylase activity, A 11479 sex as a factor, C 11385, C 11482 A 10255, A 11065, A 11102, effect of aromatic hydrocarbons, smoking and, A 10353, A 11589, A 11371, A 11477, A 11478, A 11025, A 11371 B 12621, C 10298, C 10309, A 11479, A 11866, A 11943, effect of irradiation, A 12817 C 10439, C 10560, C 10852, A 12381, A 12602, A 12747 effect of 3-methylcholanthrene, C 11016, C 11128, C 11151, effect on liver, A 10946, A 12300, A 12651 C 11272, C 11573, C 11767, A 11476, A 11477, A 11478, C 11890, C 12730, C 12751, A 11479, A 11741 BENZO(e)PYRENE F 10288, J 11323 effect on lungs, A 12123 (see also AROMATIC HYDROCARBONS.) smoking in etiology of, C 10473 effect on nacrophages, F 11247 analysis, A 12454 statistics, C 10439, C 11482 effect on microorganism, effect on DNA, A 10617, A 11496 therapy, C 10298, C 10356, A 10876 C 10473, C 1091?1, C 11115, effect on mouth, F 11467 BEN ZOPYRENES C 114C2, C 11653, C 12435, effect on prostate, A 11068 analysis, n. 12437 C 12751, F 10288 effect on protein metabolism, carcinogenicity, A 11978 iryptophan and, A 12675, A 12815, A 12299 in neoplasm induction, A 12667 C 12393, C 12647 effect on tissues, A 11977, in United Kingdom, C 11482 A 12300 BILLS fete in body, P 11247 (pee also LEGISLATION.) BLOOD CUENICAL ANALYSIS, E 12344 formation in carbohydrate in United States, I 11397, effect of smoking, A 11782 pyrolysis, A 11209 I 11398, 1 11399, I 12838, in gastrointestinal neoplasm I 12839 BLOOD CHOLESTEROL induction, A 11733, C 10417 age as a factor, F. 10257 in liver neoplasm induction, BIRTH WEIGHT in arteriosclerosis etiology, A 12652 (see also NEONATE.) E 11812 in lung neoplasm induction, effect of cigarette smoke, F 11226 cardiovascular diseases and, C 10437, C 11415, C 11762 effect of maternal smoking, E 10322, E 10422, E 11381, in lungs, A 11977 A 11262, A 11503, F 10361, E 11417, E 11457, E 11617, metabolism, A 10377, A 11938, F 10403, F 11226, F 11351, E 12172 A 12747 F 11454 coronary disease and, E 10204, metabolism in laboratory E 10257, E 10286, E 10306, animals, A 10260, A 10442, BLADDER NEOPLASMS E 10379, E 10651, E 10783, A 10532, A 10861, A 11102 age as a factor, C 11385, C 11482 E 10810, E 10959, E 10970, metabolism in liver, A 10260, aromatic amines in etiology of. E 10992, E 11223, E 11401,. A 10269, A 10362, A 10442, A 12007, C12006, C12008 E 11506, E 11596, E 11597, A 10841, A 11065, A 11102, diagnosis, C10298, C10356, E 11631, E 11639, E 11916, A 11371, A 12381, A 12602, C 10475, C11385, C11482, E 12263, E 12403, E 12742 A 12634, A 12651 C 11653, C11912, C12435, effect of nicotine, A 10777 metabolites, A 12634, A 12651 C 12647, C12751, F 10288 effect of smoking, A 10777, in neoplasm induction, A 11613, epidemiology, C 10439, C 12103, E 10257, E 10286, E 10322, A 11630, A 11758, A 11936, C 12104, C 12106, C 12107 E 10846, E 11054, E 11223, A 12010, A 12382, A 12716, etiology, C 11653, C 11769 E 11241, E 11276, E 12552, A 12826, A 12827 experimentally induced, A 11114, F 11000 pharmacology, A 11102, A 11967, A 11156, A 11291, A 11589, A 12102, A 12122, A 12299, A 11999, A 12287, A 12815, BLOOD CPTULATION, E 11154 A 12381 C 10606 (sce also 'WART FUNCTION.) in pulmonary clearance, A 11977, metabolic disorders in, C 10473, effect of carbon dioxide, D 11438 F 11040 C 10605, C 10606, C 11225, effect of cigarette smoke, E 10198, in respiratory tract neoplasm C 12647, C 12730 E 10305, E 11370, F 10462 etiology, A 10336 morbidity, C 10309 effect of smoking, E 10811, in skin neoplasm induction, mortality, B 10688, C 10852 E 11283, E 11779, E 11467, A 10399, A 11863, A 11991, occupation as a factor, A 11291, E 11944, F 19357 A 12000, A 12122, A 12124, C 10278, C 10298, C 10439, in laboratory animals, 0 12063 A 12160, A 12672, A 12698, C 11115, C 11225, C 11594, A 12817, A 12837, C 11508 C 11890, C 12103, C 12104, BLOOD COACULAT1ON, E 10518, E 11355 toxic!ty, A 12123 C 12105, C 12106, C 12107, effect of smoking, A 10259, C 12741, J 12584 C 11272, D 10919, E 10549, BENZOWPMENE CONTENT pathogenesis, C 11769, C 12272 E 10612, E 10811, E 10847, in air pollution, A 10199, predisposing factors, C 11912 E 11374 A 12376, A 12512, C 11998 determination in air, A 10199, A 12818 determination in cigarette smoke, A 11203, A 11280

336 340 BLOOD LIPIDS, F 11958 BRAIN NEOPLASMS BRONCHITIS (Coned) (pee also SMOKING.) experimentally induced, A 12306, air pollution as a factor, age as a factor, E 11276 A 12388 & 11144, B 11480, C 11351, analysis, E 12192 D 10200, D 10381, D 10456, body constitution and, E 11506 BRONCHIAL EPITHELIUM D 10520, D 10563, D 10589, cardiovascular diseases and, (see also SMOKE, CIGARETTE; D 10592, D 10593, D 10721, A 10765, E 10322, E 10518, SMOKING.) D 10884, D 10978, D 11038, E 11120, E 11381, E 11417, effect of cigarette smoke, D 11364, D 11538 E 11826, E 12001, E 12172, A 11229, D 10293, D 10598 antigen-antibody reactions in. E 12294 effect of smoking, A 10292, D 11127, D 12434 coronary disease and, A 12396, A 12573, C 11669, C 12260, diagnosis, D 1D510, D 10591, E 10257, E 10570, E 10846, C 12473, D 10598, D 10739 D 10615, D 10635, D 10121, E 11092, E 11223,E 11355, smokers vs. nonsmokers, D 11749 D 10730, D 11039, D 11049, E 11401, E 12192, E 12244, D 11365, D 11409, D 11538, E 12263, E 12743 BRONCHIAL NEOPLASMS D 11612, D 11699, D 12203, effect of nicotine, A 12195 (see also CARCINOMA, BRONCK0- D 12367 effect of :mains, A 10281, GENIC; CARCINOMA, EPIDERMUID; effect on bronchi, D 12543 A 10384, A 12795, A 12798, LUNG NEOPLASMS; RESPIRATORY effect on lung function, D 11684 E 10257, E 10322, E 10612, TRACT NEOPLASMS.) effect on lungs, D 10200. D 10722, E 10846, E 11223, E 11275, age as a factor, C 10471, D 10723, D 10753, D 10775, E 12205, F 11000 C 10850, C 12125, C 12130 D 10969, D 11699, D 12064, air pollution as a factor, D 12093, D 12098 BLOOD PLATELETS C 10850, C 11357, C 11963, effect on mucous membrane. coronary disease and, E 12403 C 12129, C 12648, C 12649 D 11141 effect of coronary disease, case history, C 10324, C 12019 epidemiology. C 12513, D 10200, E 12345 diagnosis, C 10471, C 11087, D 10326, D 10381, D 10589, effect of smoking, A 10259, C .1543, C 11865. C 11957, D 10722, D 11811 E 10847, E 11679, E 12345 C 11969, C 12017, C 12019, etiology, D 10641, D 11941, C 12130, C 12433 D 12216 BLOOD PRESSURE in East Germany, C 12433 experimentally induced, D 11127, (see a:so HYPERTENSION.) etiology, C 10324, C 11087, D 11518, D 12253 cardiovascular diseases and, C 11415, C 11669 follow-up studies, D 10512, E 10514, E 10944, E 11370, experimentally induced, A 10454 D 10594 E 11617 heredity as a factor, C 10472 heredity as a factor, D 11538 coronary disease and, E 1020t, localieatton, C 10192, C 11865 in lung neoplasm etiology. E 10306, E 10651, E 10183, metastasis of, C 12125, C 12130 C 10195, C 12129, C 12513 E 11223, E 11506, E 11596, mortality, B 11516, C 10395, morbidity, B 10450, B 11449, E 11591, E 11631, E 11793 C 10850, C 11357, C 12433 B 11510, B 12511, D 10738, effect of acetylcholine, occupation as a factor, C 10471, D 11010, D 12805 A 10423, A 10429 C 11963, C 12125, C 12129 mortality, B 10828, 8 11383, effect of cessation of smoking, race as a factor, C 12019 8 11426, B 11511, 8 11627, E 12451 in Scotland, C 12125 B 12348, B 12349, D 10520, effect of cigarette smoke, sex as a factor, C 10471, C 11865 D 10594, D 10780, D 10803, A 10583, A 11137, E 10305, smoking and, C 10192. C 10395, D 109E5, D 11157 E 10612, E 11370, F 10462 C 10471, C 10472, C 11669, occupation as a factor, A 11050, effect of nicotine, A 10499, C 11865, C 11963, C 12017, II 11511, D 10456, D 10470, E 11548 C 12019, C 12125, C 12129, D 10512, P 10561, D 10589, effect of smoking, E 11223, C 12110, C 12206, C 12433, D 10592, D 10594, D '0596, E 11'52, E 11779, F 10924, C 12643, C 12649 D 1059', D 10637, D 10641, F 11618, .112126 smoking characteristics and, D 108u1, D 10851, D 10884, C 10850, C 11051 D 11038, D 11470, D 11876, BLOOD SUGAR therapy, C 10324, C 11087, D 12543, F 10548 coronary dismiss and, E 11596, C 11957, C 119E9, C 12017, pathogenesis, D 10563, D 10590, E 11597, E 11639 C 12125, C 12206, C 12433 D 10691, D 10817, D 10829, effect of smoking, A 10384, in United Kingdom, C 10395 D 12079, D 12084, D 12216, A 10840 urban-rural influences, C 10395 D 12253, D 12522 pesticide residues and, D 11618 BLOOD VESSELS, D 12063 BRONCHITIS predisposing f(ctors, D 10.56, effect of cigarette smoke, (see also CHRONIC BRONCHOPIABCNARY D 10635, D 11612, D 12367, E 11310 DISEASE.) D 12481 effect of smoking, E 10846 age as a factor, D 10416, D 10592, preventive medicine, B 10450, oxygen consumption and, E 12252 D 10734, D 10801, D 10851, D 10734, D 11038, D 11840 D 11369, D 11518. D 11519, prognos's, D 10513, D 11767, BODY CONSTITUTION E 12556 D 11876 effect of cessation of smoking, air pollution as cause, L 10641, X 11507, K 12557 D 20722, D 10780 effect of smoking, A 12439 smokers vs. nonsmokers, E 12485

337 3+1 BRONCHITIS (Coned) CARBON MONOXIDE CARCINOCENES1S respiratory tract infections (see also CARBOXYHEMOGLOBIN (see also CARCINOGENICITY end, D 10593, D 11271, LEVELS.) REDUCTION; CARCINOGENS; D 11404,.D 11518, D 11519, in air pollution, A 10958, COCARCINOWIS; NEOPLASMS.) D 11699, D 11878 A 11)72, A 12020, A 12384, age as a factor, A 10251, sex as a factor, D 10348, E 1000, D 11197, F 10517 A 11897, A 11924, C 11528 11369, D 11878, E 12556 in arteriosclerosis etiology, antigen-antibody reactions in, smokers vs. nonsmokers, E 10603, E 30604, E 12238 A 10630, A 10684, A 11220, O 11538, E 12556, J 11622 in blood, A 1/438, E 121,1 A 11290, A 11606, A 11671, smoking and, A 12682, B 10450, in cigarette smoke, A 10236, A 11995, A 12178, A 12196, B 12108, 11 12621, C 10195, A 103b4, A 10958, A 11037, A 12378, A 12379, A 12380, C 12513, D 10200, D 10381, A 12384, A 12681, P 10517 A 12426, A 12461, A 12671, D 10456, D 10470, D 10510, in cigar smoke, A 12183 A 12716, C 12605 D 13512, D 10520, D 10551, effect on blood, A 10417, A 10938, effect of air pollutants, D 10589, D 10590, D 10592, A 11529,A 1:183, E10568, A 10191, A 10417 O 10593, D 10594, 0 10635. E 10857,E 11154, E11657, effect of antioxidants, C 12107 D 10537, D 10721, D 10801, E 11659,F 10517, F11697 effect of aromatic amines, D 10851, D 1042, D 10965, effect on central nervous A 10971, A 11156, A 11373, D 11010, D 11038, D 11132, system, A 122?0 A 12167, A 12828, C 10560, D 11141, D 11354, D 11409, effect on fetus, F 11898 C 10606, C 12106 D 11429, D 11438, D 11519, effect on heart function, E 111,4 effect of aromatic hydrocarbons, D 11570, D 11871, D 11876, effect on hemoglobin levels, A 10228, A 10396, A 10567, 11878, 0 12018, D 12216, A 11529 A 10585, A 10876, A 11025, D 12275, D 12367, D 12434, effect on lung function, E 11154 A 11068, A 11156, A 11475, D 12543, I 11712 effect on vision, F 10433, 1 10517 A 11991, A 12167, C 11053 smoking as cause, B 11242, inhalation, E 108,7 effect of aso compounds., A 11282, 11 12536, C 11583, D 10722, poisoning, A 12183, A 12384, A 11475 D 10734, D 10780, D 11518 A 12438 effect of bens(a)anthracenee, smoking characteristics and, smoking and, A 11485, D 11797, A 10352, A 10441, A 10455, C 10284, D 10803, D 12255 E 10857, E 11659, F 11697 A 10488, A 10492, A 10521, smoking classification and, in tobacco smoke, A 11199 A 10531, A 10756, A 10883, D 10884 toxicity, A 10958, A 11037, A 10900, A 10934, A 10963, smoking in etiology of, 0 10326, A 11541, A 11799, D 10690, A 11073, A 11220, A 11420, D 10515, D 10563 E 12 91, E 12200, F 11835 A 11423, A 11527, A 12256, socioeconomic effects, E 12556 A 12385, A 12407, A 12450, sputum analysis, C 11583 CARBON MONOXIDE CONTENT A 12528, A 12690 statistics, 1 10803 in air pollution, A 11610 effect of benso(10yrene, A 10706, therapy, D 10416, D 1,468, determination in blood, A 10236, A 11613, A 12646, A 12761, D 10551, D 10635, D 10730, A 11610, E 11283 A 12817, B 12551 D D 10748, 0 10753, determination in cigarette smoke, effect of cigarette smoke, D 10801, 0 11026, D 11271, A 11264, A 11372, A 12047 A 10303, A 10585 D 11404, 0 11409, D 11429, effect of dimethyleulfoxide, D 11570, D 11839, D 11840, CARBOXYHEMOGLOBIN LEVELS A 11420, A 11497, A 12421, D 11959, D 12'03, D 11235, (see also CARBON MONOXIDE.) A 12613 O 12367, D 11390, D 12756 determination, E 10568 effect of hormones, A 12669, in United Xingdom, D 11519 determination in blood, A 11610 A 12670 urban-rural influences, C 11357, effect of carbon conexide, A 12384 effect of irradiation, A 11863, D 10200, D 1.592, D 10780, effect of cigarette smoke, A 12663, A 12761 D 10884, D 11311. A 10958, E 10857 effect of smoking, A 10339, effect of smoking, A 12183, C 10830, C 11592 A 12740, E 11254, E 1.657, effect of thymectomy, A 10630, E 12191, E 12238 A 11997, A 12385, A 12470, occupation as a factor, A 10236 A 12655 smokers vs. nonsmokers, A 10236 effect of tobacco smoke, A 11589 A 11610, A 11799, A 12020, effect of tobacco tens, A 10228, CARBOHYDRATES E 10857, E 11441, F 10517, A 10303, A 10585, A 10839, biosynthesis in tobacco, F 11678 J 10320 A 11263, A 111,9 effect of unstable )pectes. determination in tobacco, CARBOXYLIC ACIDS C 11041 A 11191, A 11195, A 11196, (see also AMINO ACIDS.) effect of viruses, A 11613, A 12028 determination in cigarette smoke, A 12711 pyrolysis products, A 11209 A 11207, A 11208 effect of vitamins, 10640 as tobacco additives, A 11210 determination in tobacco leaf, endocrine environment and, A 21423, in tobacco leaf, A 10331, A 10310, A 10311, A 10312, A 12238, 12464, A 12581, A 1012, A 10313, A 10314, A 10313, A 10314 A 12532, A 12719 A 11173, A 11174, A 11175, pyrolysis products, A 12046 A 11176. A 11179, A 111)4 in tobacco leaf, A 11012

338 341 CARCINOGENESIS (Ccnt'd) CARCINOGENESIS (Coned) CARCINOGENS (Coned) heredity as ci factor, A 12023, sex as a factor, A 10251, metabolism, A 112S5 C 12706 A 11135, A 11156, A 12670 in neoplasm etiology, C 12224 inhibition, A 10191, A 10201, stress and, A 12492 structure-activity relationships, A 10239, A 10396, A 10397, viral infection and, A 10334, A 10333, A 12424, A 12490. A 10521, A 10629, A 10706, A 10336. A 10337. A 10338, A 12595, A 12596. A 12694 A 10796, A 10962. A 11001, A 11027, A 11220, A 11360, in tobacco smoke, A 10230, A 11018, A 11069, A 11076, A 11584, A 11671. A 11885, A 11589, A 12202, A 12314, A 11134, A 11255, A 11483. A 11995, A 11996, A 12256, C 11051 A 11497, A 11530, A 11613, A 1e258, A 12259, A 12379, A 11614, A 11640, A 11800, A 12388. C 11053, C 11971 CARCINOMA A 11801, A 11985, A 11995. (see also ADENOCAICINOMA; A 11999, A 12022, A 12109, CARCINOGENICITY REDUCTION NEOPLASMS.) A 12138, A 12178, A 12196. (see also CARCINOCENESIS.) experimentally induced, A 10203, A 12257, A 12266, A 12310, aromatic hydrocarbons, A 10191, A 10567, A 10640 A 12313. A 12363, A 12378. A 10227, A 1u269 A 12379. A 12380, A 12385, in cigarettes. A 10227, A 10239, CARCINOMA, BRONCHOCENIC A 12426, A 12468. A 12469, A 10580, A 11061, A 11501 (see also BRONCHIAL NEOPLASMS; A 12478, A 12488, A 12570, filters and, A 10892, C 1u216 LUNG NEOPLASMS.) A 12576, A 12581, A 12640, by processing modifications, case history. C 10256, C 10328, A 12641. A 12656, A 12660. A 10227, A 10580, A 11061, C 10763, C 10820, C 10968, A 12669, A 12672, C 11246, A 11589, A 12242, E 11761 C 11906, C 12341, C 12729 C 11731, C 11751 diagnosis, H 11425, C 10246, inhibition by antibiotics. CARCINOGENS C 10256, C 10328, C 1.683. A 10352, A 10359, A 10399, (see also CARCINOGENESIS; C 10763, C 10820, C 10166, A 10962 COCARC1NOCENS.) C 10968, C 10994, C 11008. inhibition by hormones, A 11819 in air pollution, A 10191, C 11101, C 11108, C 11390, inhibition by vitamins. A 10396 A 11485. A 12376 11357 C 11744, C 12260, C 12341, in 1,boratory animals, A 10201. analysis. A 12437 C 12729 A 10228, A 10337. A 10366. aromatic hydrocarbons, A 10197, effect of hormones. C 11906 A 10521, A 10755. A 10756. A 10152, A 11068, A 12314, me is of, B 1t425. C 10501, A 10796. A 11249, A 11255. A 12424, A 12701, C 10219, C 10692, C 11008, C 11051, A 12135. C 10219 C 11053 C 12341 mechanism of act Lon, A 10359, asbestos. A 11645. C 10500, morbidity, B 12607 A 103'7, A 10758. A 10774. P 11247 mortality, B 10999. B 11425, A 10796, A 11125, A 11595, in cigarette amok:, A 10228, C 10424 A 11619, A 11795, A 11914. A 10936, A 12184, C 11970 prognosis, C 11668 A 11917, A 11934. A 11996, in cigarette tars, A 12124 sex as a factor. C 10424. C 11747 A 12686. A 12817. C 10772, effect of actinonycin D. A 12576 smoking and, 8 12607. C 10328. C 11116, C 11528. C 12706 effect of vitamins, A 12407 C 10424, C 10763. C 10820, occupation as a factor, effect on cell division. A 11996 C 10939. C 10968, C 11108, A 10332, A 10339, C 11915 effect on cells. A 10197. A 10335, C 12260. C 12303. C 12409, predisposing factors. A 10338, i. 11289, A 11973. C 12729, D 12319 A 10332. A 10334. A 10336. A 12495. A 12700, A 12701 smoking as cause, C 10866. 1 10997 A 10339. A 12495, A 12670, effect on DNA, A 10358, A 10159, smoking in etiology of, C 10256 C 10699. C 12260 A 10934, A 10941. A 11619, sputum analysis. C 10994 research programs, A 10201, A 11996, A 12635, C 10830. statistics, 5 10999 A 10239, A 10336, A 10337, C 11053 therapy. C 10424, C 10763. A 10338. A 10339. A 10366, effect on exibryo. A 10757, C 10820, C 10866, C 11008, A 10417, A 10455, A 10492, A 1u758, A 11553 C 11101, C 11390, C 11668, A 10534, A 10585, A 10684, effect on RNA, A 10359, A 1/.619 C 11962, C 12679 A 10712, A 10757, A 10758, mechanism of action, A 10201, A 10931. A 11005. A 11007, A 10255. A 10334, A 30,35, CARCINOMA, EPIDERMOID A 11289, A 11291. A 11360, A 10336, A 10337, A 10338, (see also BRONCHIAL NEOPLASMS; A 11475, A 11584, A 11595, A 10358, A 10367, A 10630, LUNG NEOPLASMS; SKIN NEOPLASMS.) A 11613, A 11614, A 11640, A 10755. A 10796. A 10946, case history, C 10881. C 12015 A 11644. A 11646, A 11671. A 11005, A 11007, A 11289, diagnosis, C 10750, C 10881, A 11757, A 11823, A 119,/5. A 11290, A 119, A 11584, C 12765, C 12781 A 1L924, A 11946. A 12166. A 11605. A 11606. A 11612, experimentally induced. A 10366. A 12167, A 12490, A 12566. A 11671, A 11185, A 11691, A 10567, A 12528 A 12578, A 12642, A 12657, A 11892, A 11893, A 11924. pathogenesis. C 12765, C 12781 A 12664, A 12673. A 12684, A 11995. A 12108, A 12196. smokers vs. nonsmokers, C 10380 A 12685, A 12719, A 12720. A 12575, A 12671, C 1110, smoking and. C 10192. C 10195. C 10897, C 11528, C 11500. C 11731, C 11833 C 10750, C 10881, C 12005 C 11869, C 11915. C 12272

339 3q3 CARCINOMA, EPIDERMOID (Cont'd) CATECHOLAN1NES CESSATION OF SMOKING (Cont'd) therapy, C 10750, C 11090, (see also "effect on drug therapy, A 10584, J 10842, C 11532. C 12025, C 12765, catecholamine levels" under K 10205, K 10412, K 10413, C 12781 NICOTINE and SMOKING.) X 10414, K 10525, K 10533, tobacco choosing and, C 10371 effect on bladder, A 10967 K 10610, K 11495, K 11852 tuberculosis and, C 10192 effect on blood platelets, educational therapy, G 10664, E 11092 J 10497, J 10666, J 11764, CARDIOVASCULAR DISEASES effect on muscles, A 12794 K 10528 (see also ARTERIAL DISEASES; effect on oxygen consumption, effect of fear, G 12714, J 10421 CEREBROVASCULAR DISORDERS; A 12794 effect of body weight, C 10911, CORONARY DISEASE; HEART hypertension and, A 12606 F 12301, J 10842, J 11336, DISEASES; HYPERTENSION; K 12557 ISCHEMIA; THROMBOSIS.) CEREBRAL EMBOLISM AND THROMBOSIS effect on bronchial epithelium, age as a factor, E 11413, (see also CEREBROVASCULAR C 11777 11617, E 12531 DISORDERS; THROMBOSIS.) evaluation, G 10663, J 10253, alcohol consumption and, epidemiology, E 12650 J 11681, K 10507, K 11696 C 12033 mortality, E 11828 extinction (psychology) in, diagnosis, E 12251 therapy, E 11094 J 10842 diet and, A 12172, B 11434, follow-up studies, J 11681, 11457 CEREBROVASCULAR DISORDERS, E 12043 K 11507 in Egypt, E 10729 (see also CARDIOVASCULAR group therapy, A 10584, J 10391, epidemiology, E 11617 DISEASES; CEREBRAL EMBOLISM J 10670, K 10382, K 10507, etiology, 8 11434, E 10793, and THROMBOSIS.) K 10528, K 10533, K 11581 II 10943, E 11591, E 12207, diagnosis, E 11029, E 11620, hypnosis in, J 11655, K 11140, E 12315, E 12526 F 10916 K 12229, K 12458 morbidity, B 12278, E 10993 epidemiology, E 11408, E 11620, methods, A 10562, A 11541, mortality, B 10742, B 10828, E 11828 0 10663, G 10668, 0 11691, B 11234, B 11434, B 11498, etiology, B 11434 J 10491, J 10676, J 10948, B 11567, B 12140, B 12348, heredity as a factor, E 12110 J 11326, J 11328, J 11329, B 12402, B 12432, E 10993, mortality, B 10954, 8 11434, 11336, J 11557, J 11637, E 11413, E 11591, E 12161, E 11160, A 11408, E 11620, J 11655, J 11664, J 11681, E 12531 E 12383 J 11690, J 12217, J 12352, nicotine and, E 10895 predisposing factors, E 11620, K 10481, K 10507, K 10552, occupation u factor, B 12551, E 11828 K 10610, K 10782, K 10869, C 11594, E 11974 prognosis, E 11880 K 11412, K 11666, K 11696, predisposing factors, E 10204, race as a factor, P 10916 K 12036, K 12249, K 12430, E 10457, E 10651, E 10785, smoking and, II 11836, E 11620, K 12610 11813, E 11972, E 11974 E 11828, E 11880 motivation in, A 10562, C 10798, preventive medicine, E 11345, therapy, E 11620, E 11873, J 10670, J 10948, J 11275, B 11842, E 11974, B 12302, E 11880 J 11522, J 11655, J 12631, E 12408 K 10525, K 13869, K 12471 Lace as a factor, E 11160, CESSATION OF SMOKING peer group influences, J 11487 11413, E 11617, E 12531 (Leg also REDUCTION OF SMOKING; personality as a factor, E 12451, ch programs, E 11345, WITHDRAWAL CLINICS.) G 10639, K 10507, K 10529 E 12383 age as a factor, J 10509, reasons for, A 10562, E 11362, in Russia, E 11345, B 11591 J 10602, J 11520, J 11521 F 11899, G 10639, G 11691, sex as a factor, E 12531 attitudes, J 11319, J 11320, J 10676, J 10727, J 10746, smokers vs. Toolmakers, B 11299, J 12560, K 10529 .1 10948, J 11319, J 11320, B 10257, B 10120 behavior therapy, G 10671, .1 11994, .112176, K 10481, smoking and, B 12189, B 12477, G 10672, G 11691, G 11887, K 10507, K 10529, K 10869, B 12621, E 10204, E 10389, G 12714, J 10391, J 10421, K 12430 10785, E 10943, E 11093, J 10676, J 11681, K 10307, reinforcement (psychology) in, E 12207, E 12251, E 1248, K 10382, K 10516, K 10519, K 10516, K 10519, X 12471 B 12445, J 11011, J 12115 K 10533, K 10579, K 11412, research programs, G 10663, smoking as cause, A 11541, K 11495, K 11696, K 12610 J 10622, J 11138, J 12498, 8 11242, I 11711, J 10211, belief in smoking hazard', and, K 12590 J 11568, J 11690 J 11344 role of physicians, B 10270, in South Africa, B 11160, conditioning (psychology) in, J 10244, J 10264, J 10291, 11 11413 G 10667, K 10319 J 10569, J 10571, J 10602,

statistics, E 11054 counseling in, A 10584, J 11336, J 10878, J 10728, .1 10746, and, E 10785, B 11974, K 10519, 11 11507, K 11696, J 10955, 1 10982, J 11100, E 12297 X 12471 .1 11225, .111444, J 11655, therapy, E 10369, E 10729, demographic effects, J 10391, J 12217, J 12442, J 12518, E 11054, B 11458, B 11913 K 10507 X 10552, X 10869, K 11507, X. 12249, X 12471

340 344 CESSATION OF SMOKING (Cont'd) CHRONIC BRONCHOPUIMONARY DISEASE CILIARY ACTIVITY statiatica, J 10644 (Coned) (see also PULMONARY CLEARANCE.) as therapy, A 12438, D 10214, smoking as cause, D 11268, D 10551, D 10748, D 11288, effect of air pollutants, A 12095 D 127,9. J 10264 effect of cigarette smoke, D 11784, D 11849, D 14156, smoking characteristics and, A 10871, A 10947, D 10293 B 10213, E 10369, E 10795, D 12539 1 11094, E 11442, E 11695, effect of smoking, D 10739, smoking in etiology of, D 12354 D 11132 E 11832, E 11859, E 12617, statistics, D ;1049 effect of tobacco smoke, A 11989 E 12732, F 10682, 1 11451, therapy, B 11558, D 10416, F 12198, P 124411 In pulmonary clearance, D 10293, D 10468. D 10555, D 10738, D 12076, D 12077 typology of smoker* and, 0 10805, D 10865, D 10902, J 11275 D 11026, D 11109, D 21230, COCARCINOGENS, A 10488 withdraws) spontoo*, G 10639, D 11288, D 12211, 0 12275, (see also CARCINOGENES1S; G 12715 D 12390, J 10711 CARCINOGENS; CROTON OIL.) asbestos, A 11485. A 12569, MOM BRONCHOMMONARY DISEASE, CERYSENES E 12062 C 11818, C 12288 (see also AROMATIC HYDROCARBONS.) In croton oil, A 10333, A 10352, (see also BRONCHITIS; carcinogenicity. A 10971 A 10455, A 10712 EMPHYSEMA; LUNG 1ISEASES; effect on DNA, A 11619 RESPIRATORY TRACT DISEASES.) CIGARETTE PAPER age es a factor, D 10468' effect on RNA, A 11619 analysis, A 10543, A 12050 mechanism of action, A 10712, D 10685, D 11848, D 12319 effect on smoke, A 10580, air pollution as a factor, A 12698, A 12817 A 12051 in tobacco leaf, A 10303, A 10712, D 1041u, D 1V468, D 10685, toxicity, A 10580 C 10291 D 10725, D 11281 cough and, 8 11113 in tobacco tars, A 10303, A 10936, CIGARETTES A 12837 diagnosis, D 10348, D 10720, advIrtisies, I 10409, 1 10564, D 10752, D 107'4, 0 10805, I 10581,1 10989, 1 11119, COCNITI1N D 10902, D 11439, D 11049, I 11333,1 11397, I11398, (see also COGNITIVE DISSONANCE, D 11230, D 11363, D 11590, I 11399,1 11447, I11455, D 1L97, D 1e211, D 12354, LEARNING.) 1 11514, I 12291, J 10314, smoking habit and, G 17042 D 12689 J 10387, J 10990, J 11321, e ffect on bronchial epithelium, J 11335 E 10426 COGNITIVE DISSONANCE analysis, A 11265, A 12368, (see also COGNITION.) effect o. lung function. D 12081 A 12520 effect on cessation of smoking, epidendology, 8 11133, D 10685, brand d:fferences, A 11406, K 10307 D 12319 2 11612 follos-up studies, 6 11877 consumption, B 10576, C 11813, heredity as a factor, F 12420 COABUSTION TEMPERATURE G 11685, H 10241, H 10351, in cigarette smoke, A 20517 morbidity, D 10720, D 10723, H 10483, H 10503, H 11215, O 10970, D 11848, D 12058 effect of tobacco additives, H 11216, I 10409, I 10581, A 11227 mortality. B 11133, D 12100 I 11689, J 10390, J 10405, occupation as factor, effect on tar content. A 1057? J 10655, J 10675, J 10677, safe cigarettes and, A 11501 8 11877, D 10596, D 10641, J 10744, J 10974, J 11218, D 10685, D 11281, D 11673, J 11621, J 11687, J 11688, D 11932 CORONARY DISEASE J 11692, J 11753, J 12444 (see also ANGINA PECTORIS/ oxygen consumptioa and, D 22096 labeling, A 11052, 11 11844, predisposing factors. D 10348, ARTERIOSCLEROS/S; CARDIOVASCULAR 1 10409, 1 10564, 1 10581, DISEASES; HEART DISEASES; D 10718, D 10763, D 10794, 1 11397, / 11398, 1 11399, D 10805, D 11364, 9 12487 MYOCARDIAL INFARCT; THROMBOSIS.) I 11453, I 11455, 1 11514, age as a factor, E 10257, E 10201, presently* vedicice, D 14)555, I 12139, I 12173, 1 12738, D 11932 E 10280, E 10379, E 10537, I 12838, I 12339, J 10387, E 10804, E 10624, E 10845, Crogeolim, D 10720, D 10762, J 10990, J 11117, J 11118, E 11004, E 11408, E 11506, D 10805, D 11590, D 12100 J 13323 oh programa, 0 12075 E 11781, E 12190, E 12462, nicotine content, A 11059, E 12554, E 11799 sex as a factor, D 11648 A 11194, 1 11327 smokers sm. nonsmokers, 8 11877 er pollution as a factor, production, 4 10503, H 11215, E 11303 smoking and, B 12477, D 10200, H 11216 D 10748, D 10416, D 10444, alcohol consumption and. E 10280, tar content, A 11039, J 11327 E 10400, E 10970, E 11850, D 10635, D 10685, D 10716, taxation, H 10351, 1 10660, D 10762, D 10005, D 10865, E 12013, E 12554 1 11322, 2 10658, 2 11313, arteriosclerosis and, E 11695 D 10942, D 114)49, D 11109, J 11418 D 11281, D 11673, D 12211, behavior and, E 13990, E 12111 D 12320. D 12190, D 12414, body constitution and, B 10249, D 12487, D 13791, J 1101! E 10190, E 10257, E 10570, E 13506, E 12245, E 12248

341 34,5 CORONARY DISEASE (Coned) CORONARY DISEASE (Cont'd) CORONARY DISEASE (Coned) case history E 12397 nicotine and, D 10919, E 10769 smoking and, E 10824, E 10845, diagnosis, E 10824, E 10874, occupation ea a factor, A 10996, E 10870, E 10874, E 10899, E 10998, E 11029,E 11055, Is 12280, E 10250, E 10271, E 10922, E 11028, E 11042, E 11316, E 11430,E 11466, E 10379,E 10680, E10870, E 11055, E 11254, E 11355, E 11825, E 11928,E 12515, E 10991,E 11303, E11856, E 11382, E 11401, E 11466. E 12748 E 12111,E 12185, E12241, E 11546, E 11638, E 11639, diet and, B 10249, B11312, E 12343 E 11654, E 11695, E 11773, E 10266, E 10286, E 10304, pathogenesis, D 10817, E 10213, E 11778, E 11856, E 11972, E 10306, E 10379, E 10714, E 10769, E 10795, E 10913, E 12013, E 12154, E 12161, E 10783, E 10959, E 10970, E 1135D, E 12397 E 12296, E 12118, E 12350, E 11259, E 11314, E 11355, personality as a factor, E 10190, E 12355, E 12475, E 12544, E 11401, E 11631, E 11972, E 10280, E 10680, E 10870, E 12552, E 12553, E 12554, E 12029, E 12161, E 12244, E 10899, E 11088, E 11639, E 12721, E 12726, E 12748 E 12248, E 12282, E 12403, E 11928, E 12111, E 12550 smoking as cause, C 11346, E 12480, E 12499, E 12553, predisposing fac.ors, C 12976, E 10213, E 11631, E 11657, E 12554, E 12742, E 12743 C 11979, E 10204, E 10250, E 11820 effect of cholesterol, E 12290, E 10257, E 10261, E 10304, smoking characteristics and, E 12742 E 10306, E 10400, E 10440, B 10546, E 10261, E 10262, effect of smoking, E 11834, E 10570, E 10611, E 10643, E 11223, E 1135S, E 11463, E 126/7 E 10648, E 10783, E 10795, E 12608, E 12650 electrocardiographic effects, E 10810, E 10874, E 10878, smoking classification and, E 11316, E 11443, E 11466, E 10899, E 10922, E 10943, E 11778, E 11821 E 12350 E 10996, E 11028, E 11088, smoking in etiology of, E 10453, epidemiology, B 10249, E 11110, E 11254, E 11314, E 10526, E 10611, E 10769, C 11979, D 10919, E 10213, E 11555, E 11382, E 11401, E 10846, E 11314 E 11261, E 10526, E 10570, E 11466, E 11546, E 11638, socioeconomic effects, C 11976, E 10611, E 10651, E 10795, E 11654, E 11773, E 11778, E 11026, E 11738, E 11856 E 10922, E 11223, E 11596, E 11793, E 11821, E 11913, etresa and, C 11976, E 10286, E 11597, E 11631, E 11639, E 12245, E 12247, E 12246, E 10484, E 10680, E 10899, E 11654, E 11695, E 11738, E 12296, E 12316, E 12318, E 10996, E 11355, E 11359, E 11834, E 11954, E 12029, E 12344, E 1.7350, E 12365, E 11414, E 11928, E 11990, E 12142, E 12185, E 12188, E 12515, E 12544, E 12721, E 12553, E 12554 E 12241, E 12263, E 12290, E 12748 therapy, E 10271, E 10304, E 12496, E /2650, E 12748 preventive medicine, B 1228J, E 10369, E 10648, E 10795, etiology, 8 11144, E 10453, B 12504, B 12736, E 10266, E 11054, E 11094, E 11253, E 10714, E 10769, E 10970, E 10440, E 10783, E 10991, E 11338, E 11542, E 11825, E 11303, E 11411, E 11695 E 1131m, E 11401, E 11430, E 11928, E 12041, E 12154, follow-up studies, E 11004 E 11636, E 11695, E 12161, E 12726 heredity as a factor, B 11299, E 12241, E 12248, E 12254, in United Kingdom, E 11303, E 10191, E 10627, E 10799, E 12290, E 12318, E 12480, in United States, E 11054 E 11042, E 11055, E 11110, 1 12497, E 12499, E 12735, E 11596, E 11820 E 12746 COTININE in India, C 11979, E 12115 prognosis, E 11004, E 11254 (see also ALKALOIDS, TOBACCO; in Israel, E 10393 race es a factor, E 10643, NICOTINE; NICOTINE METABOLITES.) metabolic disorders in, E 10190, E 10878, E 11408, E 12350, carcinogenicity, A 12638, A 12687 E 12247 E 12475, E 12553, E 12554, distribution in body, A 11660 morbidity, E 10795, E 10870, E 12717 as nicotine metabolite(s), E 10991, E 10993, E 10998, sex as a factor, E 10306, A 10325 E 11004, E 12190, E 12496, E 10804, E 10878, E 1L408, E 12544 E 11781, E 12190, E 12462, COUGH mortality, 8 10249, B :0601, E 12496, E 12550, E 12553, (see oleo RESPIRAIORY TRACT B 11244, 8 11312, B 11434, E 12554, E 12799 DISEASES.) B 12432, 8 12530, C 11976, smokers vs. nonsmokers, E 12343 air pollution as factor, D 10919, E 10280, E 10537, smoking end, A 11503, D 10329, D 10960 E 1)643, E 10648, E 10783, 8 10249, B 12280, B 12324, effect of cessation of smoking, E 10795, E 10804, E 10824, B 12530, B 12536, B 12618, D 10942 E 10931, E 10993, E 11004, D 10919, E 10190, E 10250, lung neoplasms as cause, C 10284, E 11160, E 11254, E 11359, E 10257, E 10266, E 10271, C 10702, C 12767 E 11411, E 11463, E 11631, E 10280, E 10286, E 10304, smokers vs. nonsmokers, D 10448, E 11638, E 11654, E 11657, E 10306, E 10379, E 10393, D 10615, D 10751, D 10960, E 12031, E 12142, E 12241, E 10400, E 10440, E 10451, D 11244, D 11699, D 12759 E 12244, E 12296, E 12343, E 10457, E 10484,E 10537, smoking as cause, C 11583, E 12496, E 12544, E 12608, E 10542, E 13627, E 10643, C 11807, D 10200, D 10329, E 12717, E 12799 E 10648, E 10783, E 1081:, D 10593, F 11089, 3 11520, 11521

352 CROTON OIL EMPHYSEMA (Coned) EMPHYSEMA (Coned) (see also COCARCINOGENS.) bronchitis and, D 10470, D 10563, smoking as cause, I 11242, carcinogenicity, A 12450 D 10589, D 10590, D 10591,, B 12536, D 11518, D 11784, as cocarcinogen(s), A 10333, D 10965, D 11157, D 11230, D 10296 A 10352, A 10358, A 10397, D 11404, D 11538, D 11699, smoking characterietice end, A 10399, A 10455, A 10488, D 12078, D 12084, D 12093, B 11480, D 12539 A 10934, A 12011, A 12484, D 12098, D 12487 smoking in etiology of, D 10535 A 12613 diagnosis, D 10510, D 10591, therapy, D 10277, D 10416, effect on cell division, D 10705, D 11049, D 11230, D 10551, D 10554, 0 10748, A 1C358 D 11337, D 11675, D 11857, D 11230, 0 11337, D 11404, D 12168, D 12203, D 12840 D 11428, D 11839, D 11849, CYANIDES effect on enzyme activity, E 12283 D 11857, D 11951, D 12203, (see also THIOCYANATES.) effect on lungs, D 10294, D 12840 determination in blood, A 12532 D 10723, D 10969, D 12059, effect on enzyme activity, D 12064, D 12066, 0 12092, ESOPHAGEAL NEOPLASMS A 10872 D 12093, D 12094, D 12098, (see also GASTROINTESTINAL D 12440 NEOPLASMS.) epidemiology, D 10589, D 10787 alcohol consumption and, C 10419, etiology, D 11230, D 12193, C 10930, C 12307, C 12521 D 12489, D 12525 areca Chewing and, C 10346 experimentally induced, A 11298, diagnosis, C 12521 DIABETES, E 11414, E 11457 D 10330, D 10787, D 11105, diet and, C 10347, C 10419, cardiovascular diseases and, D 1i138, D 11260, D 11332, C 11789 E 12315 D 12067, D 12293, D 12440 epidemiology, C 10646, C 11573 coronary disease and, E 10306, heredity as a factor, D 11337, etiology, C 11459, C 11789 E 10453, E 10643, E 12247 D 11677, D 1210:, F 12420 experimental', induced, A 11992 nicotine and, A 12734 inhibition, 0 1161: mortality, B 11523 morbidity, B 11449, 8 11510, predisposing factors, C 10347, DIBEN2(a,h)ACR1DINE D 10738 C 11904 analysis, A 12454 mortality, 8 10828, B 11383, smoking and, C 10347, C 10411, D 10520, D 10780, 0 10965, C 10855, C 10930, C 11776, D18ENZ(a,h)ANTHRACENE D 11157, I; 11784 C 11788, L 12307, C 12521 (see also AROMATIC occupation as a factor, D 10566, snuff-dipping and, C 1034) HYDROCARBONS.) D 10589, D 10595, D 10596, statistics, C 10930 analysis, A 12643 D 10597, D 10787, D 10851, therapy, C 12521 in brain neoplasm induct!on, D 12525 A 12388 pathogenesis, D 10563, D 10590, EYE DISEASES carcinogenicity, A 10469, D 10591, D 10595, D 10695, (see also AMBLYOPIA, TOBACCO.) A 11068, A 12424 D 11157, D 11230, D 11525, smoking and, F 10856, F 11261 effect on DNA, A 10876 D 11593, D 12067, D 12084, effect on prostate, A 11063 D 12440, E 12283 in skin neoplasm induction, predisposing factor, 8 11558, A 10630, A 11863 D 11677, 0 12101 preventive medicine, D 10482 DIBENZO(a,l)FFREVE prognosis, D 10510 (see also AROMATIC HYDRO- race as a factor, D 12489 FETUS CARBONS.) research programs, D 12075 (see also INFANT MORTALITY; in neoplasm induction, A 11937 respiratory tract infections and, NEONATE; PREGNANCY; PRImATIMITy.) D 11404, D 11593 effect of taboo monoxide, sex as a factor, 8 11558, E 10568 D 10348, D 10482, D 10776, effect of smoking, D 11157, D 12489 11313, J 11283, F 10361, smokers vs. nonsmokers, J 11622 F 10461, F 10540, F 10834, smoking and, A 11298, 8 11558, F 11351, F 11395, F 11835 EMPHYS IA B 12621, C 11968, C 12325, effect of nicotine, A 11148 (sea also CHRONIC BRONCHO- D 10416, D 10482, D 10510, effect of nitromamices, A 10758 TELHONARY DISEASE.) 10520, D 10551, D 10554, &gm as a factor, D 10277, D 10563, D 10589, D 10590, FIBRINOLYSIS, E 10992 0 10416, D 10482, D 10776, D 10595, D 10705, D 10718, D 10851, D 11157, 0 11525, D 10720, D 1074E, D 10776, FILTERS, A 12053 D 12525 D 10787, D 10851, D 10942, alkaloid restotion, A 11212 air pollution as a factor, D 10965, D 11230, D 11/60, cellulose acetate, A 11198 R 11480, C 10823, D 10520, D 11364, D 11428, D 11438, charcoal, A 10238, A 11200 D 10589, D 10748, D 10776, D 11593, 0 11677, D 12275, evaluation, A 10225, A 10237, D 10978, D 11364, D 11677 D 12525, I 11712 A 10238, A 10833, A 10892, A 11059, A 11224, A 11501 11700, 1 11713

343 3447 FILTERS (Coned) GASTROINTESTINAL NEOPLASMS (Coned) HETEROCYCLIC NITROGEN COMPOUNDS nicotine retention, A 11167, etiology, F 10654 (Cout 'd) 1 11701 experimentally induced, A 11733 carcinogenicity, A 11255, A 11483, phenol retention, A 10237, mortality. C 10909 A 11491 A 11197, A 11212 smoking and, C 10855, C 10930, in cigarette eAr:e, A 12750 polonium -27.0 retention, i 10858 C 11788. F 10654 determination. A 12614 pyridine rmtentioe. A 11212 statistics. C 10930 determination in tobacco smoke. safe cigarettes and, A 10947, A 12156 A 11224, J 12429 GLYCERIN effect on DNA, A 11967, A 12745 selective retention, A 10237. (see also HUHECTANTS; TOBACCO effect on muscles. A 12759 A 10238, A 11161, A 11198, ADDITIVES.) in tobacco smoke, A 12045 A 11201 determination in tobacco, A 11656 toxicity, A 11973 ter tstention, A 10225, A 11197, 1 11701 GLYCOLS HUMECTANTS (get alto HUMECTANTS; TOBACCO (see also GLYCERIN; GLYCOLS; SIPES ADDITIVES.) 1UBACCO ADDITIVES.) (see also Acc:Drmrs.) determination in tobacco. A 11658 effect on tobacco pyrolysis. smoking as cause, I 11705 A 12049 GVN:COLOGIC NEOT' SIAS glycols, A 12049 epidemiology. C 10693 experimentally induced, A 12580, HYPERCHOLESTEREMA A 12581, A 12582 (see also BLOOD PRESSURE.) predisposing factors. C 10693 age as a factor. E 12282 smokers v.e. nonsmokers, P 11683 cardiovascular diLeaser and. GAS PhASE, CIGARETTE SMOKE, E 12001 A 11015 coronary disease and, E 10451, (see also TARS, CIGARETTE.) E 10570, E 12282. E 12317. analysis, A 10234. A 10634, 12480, E 12742 A 11207, A 11207. A 11372, smoking and. C 10446, E 10549 A 11531 therapy, E 11826, E 12282 effect of processing methods, HEART DISEASES A 10226, A 12682, J 12622 (see also CARDIOVASCULAR DISEASES; HYPERTENSION effect on cells, A 10964, CORONARY DISEASE; PULPONAP.Y (see also BLOOD PRESSURE; A 11424 HEART DISEASE.) CARDIOVASCULAR DISEASES.) effect on ciliary activity, diagnosis, t, 11803, E 12219 in arteriosclerosis etiology. A 19474 morbidity, B 11368 E 11814 effect on microorganisms, mortality. B 11988, E 12728 cardiovsacular diseases and, A 10476, A 11973 occupation as a factor. E 11954 E 10101, E 11414, E 11591 filtration, A 10238, A 11198, predisposing factors. E 10460, in coronet, disease etiology, A 11211, A 11212 E 10785, E 10793. E 10845, E 10453, E 10570, E 11088, toxicity, A 10474,A 11973, E 10444 E 11611, E 11639, E 117P1 D 10717 preventive medicine, E 12219 epidemiology. E 12137 smoking and, E 10460, E 10514, experimentally induced. E 12060 GASTRITIS E 10620, E 10785, E 108.1, predippoJing factors, E 1058, (sem also CASTROINTEMML E 10845, E 10944, E 11214, 7 12112 DISEASES.) E 11432, E 12447, E 12735, psych social aspects, F L2312 predisposing facte:, F 12(03 I 11701 race as factor, E 11160 smoking and, A 10411, C 1005, socioeconomic effects, E 12728 smoking and. E 10301, E 10549, 12603 therapy, E 11432, E 12219 E 11358. E 11591, E 12137. tLerapy, T 12601 3 11622 HEART FUNCTION stress and. F 12312 GASTROINTESTINAL DISEASES (see also BLOOD CIRCULATION.) therapy, E 10301, E 10369, (ses also GASTRITIS; ge as factor. D 12503 E 11358, E 11362, 2 11855 GASTROINTESTINAL NEOPLASM; effect of smoking, D 12503, LIVER CIRiIOSIS; MOUTH E 10248, E 10319 DISEASES; ULCER, PEPTIC.) oxygen conaumption and. E 10457 in Indio, B 11449 h programs, E 12061, mortality, B 10951 E 12062 smoking and, C 10855 HETEROCYCLIC NITROGEN CONFOUNDS, INFANT MORTALITY GASTROINTESTINAL NEOPLASMS A 12119 (sm. also FETUS; MORTALITY; (lea also ESOFHAGEAL NEOPLANS; (see also ALKALOIDS, TOBACCO; NEONATE.) GASTROINTESTINAL DISEASES; NICOTINE DERIVATIVES; FIRMIN11.) effect of maternal smoking, INTESTINAL. NEOPLASMS; LIVER analysis, A 12750 A 11262, A 11503, B 11313, NEOPLASMS; MCHITH NEOPLASMS; F 10540, F 10854, F 11151, STOMACH NEOPLASMS.) F 11454

344 34? INIANT MOLTALITY (Cont'd) LARYNGEAL NEOPLASMS (Cont'd) LEGISLATION (Cont'd) statistics, 1311305, B 11499, etiology, A 10454, C 10700 1 11718, I 11719, I 11720, E 11516 metastasis of, C 11633, C 11971 1 11721, 1 1172 ?, I 12285, in United States, B 11499 multiple primary, C 10608, 1 12836 C 11633 evaluation, 1 12838 INTESTINAL NEOPLASMS predisposing factors, C 11633, labeling, C 11626, C 11642, (see also GASTROINTESTINAL C 1'493 I 10650, I 10653, I 10661, NEOPLASMS.) sex as a factor, B 10316, I 10749, I 11396, I 11397, therapy, C 12533 C 10431, C 11078, C I 11398, I 11399, I 11453, C 11352, C 11693, C 12194 1 11554, I 115E0, 7 11,87, IRRADIATION smoking and, C 10431, C 10466, I 11623, I 11625, I 11648, effect on tissues, C 12323 C 10849, C 10881, C 11213, I 11689, I 11709, 1 17706, as therapy, C 11791 C 11352, C 11356, C 11633, 1 11707, I 11718, I 11720, C 11693, C 11759, C 11989, I 17139, J 10349, J 10662 ISCHEMIA, E 11092 C 12194, C 12323, C 12416, tar content and, I 11554 (see also CARDIOVASCULAR C 12431, C 12452 in United Kingdom, 1 10653, DISEASES.) smoking in etiology of, C 11078 1 10749, 1 12139 age as a factor, E 10514, therapy, C 10466, C 10608, in United States, C 11626, E 11259, E 11441 C 10881, C 11091, C 11352, H 10351, 1 1065C, 1 IWO, diagnosis, E 12183 C 11356, C 11633, C 11971, 1 10661, I 10360, I 11623, epidemiology, E 10243, C 11E81, C 12194, C 12311, I 11648, I 11589, J 10344, E 10906, B 11765, E 11815, C 12323, C 12749 J 10658, J 11687 8 11954, E 12243, E 12277 mortality, B 10601, B 11312, LEAD LZUKEM1A E 11259, E 11411 determination fn cigarette smoke, (see also NEOPLASMS.) predisposing factors, B 11312, A 1153' bena(e)acthrecenes as cause, E 10243, E 10393, 8 10400, A 12258 E 10422, E 10432, E 10514, LEAD-210 effect of viral Wectita. E 10899, E 11250, E 11111, distribution in body, A 12474 A 1,258 F. 11766, E 11015, E 110 3, experimentally induced, A 10354, E 12710 LEARNING A 10469, A 10862, A 10963, preventive medicine, E 10243, (tree also CO6NITION.) A 11018, t 11071, A 11075, E 11765, E 11815, E 11842, effect of nicotine, A 10979, A 11136, A 12310, A 12379, E 11939, E 11983, E 12187, A 12616, G 10575, G 10588, A 12655, C 10437 E 12742, J 11764 G 1)121, 6 11122, G 12609 sex as a factor, E 11441 LEUKOPLAKIA, C 11984 smeaing and, B 11836, E 10243, LEGISLATION (set also MOUTH DISEASES.) E 10393, E 10400, 1 10422, (see ale° BILLS.) alcohol consumption and, C 11459 E 10432, E 10514, 1. 11259, adveztisrni, C 11626,I 10409, ereca Chewing and, C 11561, E 11441, E 11766, E 11815, 1 10478, I10581, 10650, C 12411, I' 12333 E 11842, E 11939, E 11983, 1 10661, 110749, 1Ions, diagnosis, C 12501 11 12243, E 12345, E 12411, 10860, 110975, 110989, experimental., induced, A 11982 E 12710 I 11233, 111239, 111396, pipe smoking ani, F 11462 stress and, B 12262 I 11397, 111398, I11399, smoking and, C 10802, C 10863, therapy, E 1(906, 8 11765, 1 11400, 111514, I11587, C 10910, C 11021, C 11564, E 11939, E 12491 1 11623, I11623, I11648, C 11693, C 12170, C 12413, urban-rural influences, I 11689, I11700, 11701, C 12502, C 12597, P 10268, E 11259 I 11702, 111703, I11704, 7 10064, P 11462, P 11912, 1 11705, I11706, I11707, F 12333 I 11708, 111709, I11710, smoking as cause, C 10849, 1 11711, 111712, 111714, F 10574 1 11718, 112116, 112173, smoking classification and, 1 12738, J10344, J11117, C 11854 J 11118 roking in etiology of, C 11459 LARYNGEAL NEOPLASMS in antismoking co paigns, snc11-dipping and, C 11564

(!luAlta RESPIRATORY TRACT I 10479, I 1066 , I 10860, therapy, C 10480, C 10863, DISEASES.) I 10989, I 112.:. I 11322, C 12502, P 10268 age as a factor, B 10316, I 11333, I 1148,, I 11720, tobacco chewing and, C 10802, C 10914, C 11009, C 11078, I 11721, I 12285, I 12738, C 11021, C 12170, C C 11352 J 11321, J 11343 F 12333 alcohol consumption and, in Csnads, 1 10479, I 11488, C 11613 11700, 1 11701, I 11702, LIP NEOPLASMS irate awing and, C 10443 I 11703, 1 11704, 1 11705, (Les also MOUTH NEOPLASMS.) 'WO history, C 11759 1 1106, 1 11707, 1 11708, mustn't, of, C 11509 diagnosis, C 1U8F1, C 12431 I 11709, 1 11710, 1 11711, mortality, 8 11433 epidemiology, 8 10465, 1 1171i. 1 11713, 1 11714, smoking cod, C 11592, C 11964,

C 10431, C 11078, C 11564 11715, T. 11716, I 11717, C 11984

?:5 399 LIP NEOPLASMS (Cont'd) LUNG DISEASES .,ICont'd) LUNG NEOPLASMS atatietice, B 10915, C 10402 FIRROSIS; RESPIRATORY TRACT (see also BRONCHIAL NEOPLASMS; therapy, C 11509, C 11964, C 11984 DISEASES.) CARCINOMA, BRONCHOGENIC; age an a factor, D 10817, CARCINOMA, EPIDERMOID; 1IVER CIRRHOSIS D 12055, D 12441 RESPIRATORY TRACT NEOPLASMS.) farm also GASTROINTESTINAL air pollution as A factor, in Africa, C 10425 VISEASES.) C 10823, D 10555, D 10725. age as a factor, A 11918, age as a factor, F 11315. D 10882, 0 11158 B 11307, B 12394, C 10380, F 12158 alcohol consumption and, C 10410. C 10449, C 10652, alcc of consumption and, D 11301 C 11393. C 11661, C 11727, 11112, C 11056, C 11459, antigen-ant1Lody reactions in. C 11790, D 12441 C 12533, F 10923, F 12465 D 11532 air pollution as a factor, arsenic and. C 11860 diagnosis, C 11968. D 10743. R 10267, B 11269. B 11901, diagncais, C 12813. F 122u8. D 12074 B 12752, C 10273. C 10401. F 12710, F 12465, F 12467 effect on lung function, D 10775. C 10652. C 10823, C 11006. dist and, F 11315 D 10969, D 12078. D 12339 C 11041. C 11346, C 11389, experimentally induced, A 12449, epidemiology, D 10607 C 11694. C 11839. C 11894. A 12506, P 11315. P 12359 experimentally induced, A 12114, C 12005, C 12226, C 12265, heredity as a factor, F 12158 D 12072, D 12096 C 12600. D 11879 B 11864 morbidity, 8 11368 arsenic and, C 12762 mortality, B 11146, 8 11864, mortality, D 11301 in Australis. I 11453 K 12117, B 12201. C 12466, occupation as a factor, 8 12551, benzo(a),yrene and. C 12226 F 12819 D 10807 bronchitis and. C 10284, pathogenesis, F 12467 pathogenesis, D 10817, D 11274. D 10803 predisposing factors, B 11112, D 12055. D 12056 bronchitis in etiology of C 11123. F 11571 sex as a factor, D 10294 C 10702 cex ac a factor, F 11315 smoking and, A 12114, B 12280, in Bulgaria. B 10915 smoking and. C 10430 D 10294, D 10475, D 10555. in California, B 10873 statistics, B 11864, C 11123. D 10607, D 10882, D 11301, In Canada, R 10687, 8 11383. 10923, F 10972 D 11437, D 12339. D 12797, C 11661 D 12825, I 11707 carcinogenesis, A 12184, LIVER NEO7LASMI, C 11056 smoking as cause, D 12414 C 11751. C 12524 (see also GASTROINTESTINAL smoking in etiology of, D 10851 case history, B 11394, C 10279, NEOPLA'MS.) therapy. D 11437, D 72825 C 14401, C 10983, C 11388, diagnosis, C 12810 C 11745. C 11858, C 12021, experimentally induced, LUNG FUNCTION, D 12059, D 12066, C 12035, C 12261. C 12269, A 10251, A 10796. A 10862. D 12069 C 12784, C 12785 A 10931, A 10971, A 1;...12. (see also RESPIRATORY FUNCTION chronic bronchopulmonary disease A 11024, A 11097, A 11135, TESTS in etiology of, 10702 A 11248, A 11282, A 11284, age as factor, D 12503 in Connecticut. C 10983 A 11795, A 11975, A 12022, air pollution as a factor, cough and, C 11583, C 118C? A 12257, A 12355, A 12449, D 11347, D 11592 in Czechoslovakia, B 11450, A 12509, A 12601, A 12671 effect of acetylcholine, D 11682 C 10418, C 10939, C 12806 morbidity, C 11123 effect of cigarette smoke, in Denmark, C 11101 mortality. B 11523, C 12466 D 10452, D 10637, D 10716, diagnosis, B 11425, C 10279, predisposing factcrs, C 12813 D 10723 C 10438, C 10449, C 10467, smoking and, C 10430 effect of cigar smoking, 0 12030 C 10521 C 10626, C 10628, statistics, C 11123, F 10972 effect of histamine, D 11682, C 10652, C 10696. C 10701, D 12087 C 10702, C 10726, C 10813, 108ELINE effect of smoking, D 10200, C 10911, C 10983, C 11219, in cessation of smoking. D 10475, D 10753, D 11684, C 11350, C 11388, C 11390. K 1C412. K 10525, K 11,67, D 12030, D 12689. D 12840 C 11405, C 11456, C 11534. K 11495 effect of surfactants, A 10550, C 11536, C 11578, C 11588. effect on bladder, A 10967 D 10607, D 12722 C 11608, C 11661, C 11727, effect on blood circulation, in laboratory animals, 0 C 11745, C 11763, C 11858, K 10412 D 12071 C 11965. C 11966, C 11968, effect on gastrointestinal occupation as a factor. 0 12037. C 12025, C 12035. C 12120, tract, A 11440 D 12321, D 12503 C 12239, C 12269. C 12325, effect on nervous system, race as a factor, D 11306, C 12409, C 12410, C 12428. K 10412 D 12406 C 12500, C 12589, C 12605, effect on respiratory tract, ch programs, A 12089, C 12765, C 12766, C 11768, A 11440 D 12085 C 12769, C 12770, C 12771, pharmacology, A 11440, A 12418 smokers vs. nonsmokers, D 10592, C 12782, C 12783, C 12765. D 10721, D 11306, D 11992, C 12785, C 11786, C 12788. LUNG DISEASES D 12037, D 12321, D 12406. C 11789, C 12791, C 12793. (ill also CHRONIC MONCNO- D 12503 C 12800, C 12808, C 12810, PULMONARY DISEASE; PULMDNARY smoking anJ, D 12018 D 11363

346 350 LUMP NEOPLASMS (Coned) LUNG NEOPLASMS (C-Ated) LUNG NEOPLASMS (Cont'd) effect of irradiation, occupation as a fActnr, A 12529, smoking and, C 11392, C 11405, C 10404, C 10420 A 12569, B 11147, B 11334, C 11471, C 11536, C 11573, effect of unstable species, B 11511, C 14273, C 10419, C 11585, C 11608, C 11632, C 11585 C 10425, C 10500, C 10698, C 11635, C 11727, C 11740, effect on nervous system, C 11041, C 11124, C 11585, C 11776, C 11807, C 11818, C 12789 C 11632, C 11635, C 11740, C 11838, C 11875, C 1094, endocrine disorders in, C 11818, C 12199, C 12212, C 11966, C 11968, C 11980, C 10467, C 12790 C 12224, C 12240, C 12762, C 12014, C 12016, C 12120, epidemiology, B 10375, B 10E43, J 10264 C 12199, C 12212, C 12240, C 10698, C 11048, C 11389, pathogenesis, C 10898, C 11279, C 12755, C 12269, C 12295, C 11632, C 11(94, C 11894, C 11471, C 11526, C 11608, C 12 Al, C 12371, C 12374, C 11966, C 12169, 1 11710, C 12524, C 12589, C 12765, C 12386, C 12460, C 12500, B 11761 C 12766, C 12767, C 14783, C 12524, C 12589, C 12598, etiology, A 11918, B 10496, E 11278 C 12600, C 12645, C12793, C 111117, C 11966, C 12005, peptic ulcer and, F 10317 U 11879, G 11685, I11710, I 11716 personality as a factor, C 11113, I 11712, J 10383, J 10675, experimentally induced, A 10428, C 12371, G 10302 J 10761, J 11011, J 11060, A 10454, A 10567, A 10831, physical examination, C 11471 J 11321, J 11323, J 11321, A 10862, A 10971, A 11130, in Poland, B 10415, B 11155 J 11636, J 11753, J 12351 A 11.135, A 11645, A 11118, predisposing factors, C smoking as cause, A 10332, A 11946, A 12022, A 121:', C 10524, C 10696, C 10921, A 10334, A 11541, B 10821, A 12613, A 12619, A 12657, 4, 12361, C 12605 B 11242, b 12536, B 12809, A 12663, C /1389, C 11415, preventive medicine, B 12504, C 10216, C 10449, C 10726, C 12524 C 11387, C 11389, C 11751, C 11583, C 11656, C 11661, in Finland, C 11087, C 11694 C 11858, C 11875, C 11980, C 11676, C 11694, C :1747, in France, C 11536 C 12120, C 12605, C 12648, C 11777, C 11813, C 11998, in Germany, B 10927, C 11041, C 12649, C 12820 :1 12762, C 12800, C 12820, C 121 2 prognosis, B 11515, C 10691, 1 11453,I 11580,I 11700, giant cell tumors. C 10501, C 11392, C 11393, C 11588, I 11705,I 11715,1 11716, E 11278 L 11608, C 11925, C 12792, J 10264,J 1,568,J 12476 heredity as a fector, C 10437 1 11580 smoking characteristics and, C 10850, C 11656, C 12016, psychosocial aspects, C 12460 8 10546, B 10613, C 11346, C 12645, J 11753 race as a factor, B 11307, C 11389, C 11694, C 12005, in Hungary, 0 12809 C 11393, C 12169, C 12174, E 11359, J 1076: in India, C 10279 C 12'1.6 smoking classification and, in Israel, 8 10406 research programs, 8 10496, B 10546, C 10284, C 11594 in Italy, C 10524 C 11415, C 11762, C 12371 smoking in etiology of, A 10428, in Japan, C 10652 respiratory tract infections rnd, C 10538, C 10821, C 11128, metastasis of, C 10923, C 10195 C 11272, C 11415, C 12513, C 11388, C 11392, C 11658, in Rhodesia, C 12762 J 10539 C 11925, C 11957, C 12239, selenium and, C 11246 in South Africa, B 11492, C 12261, C 12269, C 12410, sex as a factor, A 11135, C 12374, C 12386 C 12605, C 12765, C 12766, P 10485, D 11145, B 11774, statisecs, B 10375, B 10687, C 12767, C 12768, C 12783, 8 12394, C 10380, C 10404, 6 10843, B 10844, B 10915, C 12787, C 12789, C 12791 C 10410, C 10418, C 10449, B 10927, B 11155, B 11269, morbidity, B 11510, C 12806, C 11393, C 11526, C 11676, B 11273, B 11431, B 11515, J 12622 C 11727, C 11925, C 12005, C '0449, C 10508, C 10524, mortality, B 10485, B C 12016 C 10652, C 10813, C 11101, B 10844, 8 11145, B 11318, emotes' ve. nonsmokets, C 12226 C 11219, C 11267, C 11189, B 11450, B 11492, B 11511, smoking and, A 10892, A 11503, C 11393, C 11578, J 10948 B 11515, B 11516, 15 12349, A 11837, A 12639, A 12682, stress end, C 11113. C 12371 B 12398, II 12752, 8 12809, B 10267, B 10290, B 10375, in Switzerland, E 11273 C 10273, C 10395, 10420, B 10406, B 10687, B 11147, therapy, B 11515, C 10420, C 10726, C 10813, C 11456, B 11269, B 11383, B 11394, C 10438, C 10449, C 10524, C 11790, C 12524, C 12787, B 11492, 11 11586, B 11901, C 10541, C 10628, C 10652, C 12806, C 12808, I 10749, 12308, B 12394, B 12398, C 10591, C 10726, C 11083, I 11580 II 12530, 1 12621, C 10195, C 1136E, C 11390, C 11392, multiple primary, C 10983, C 10196, C 10380, C 10395, C 11393, C 11514, C 11516, C 11965, C 12810 C 10401, C 10404, C 10410, C 11578, C 11588, C 11745, in Netherlands, D 10465 C 10415, C 10423. C 10446, C 11813, C 11675, C 11925, nttrossainas and, A 10229, C 10500, C 10508, C 10524, C 11965, C 12014, C 12016, A 10454, A 42613 C 10699, C 10701, C 10898, C 12025, C 12120, C 12169, in Norway, C 10350, C 11046, C 10917, C 10921, C 11006, C 12428, C 12500, C 12765, C 11694 C 1111), C 11151, C 11219, C 12272, C 12773, C 12774, C 11387, C 11388, C 11390 C 12775, C 12776, C 12777,

347 351 LUNG NEOPLASMS (Cont'd) MORJ10ITE (Coned) MORTALITY (Cont'd) therapy, C 12778, C 12779, lung neoplasms, B 10406, 8 10927, lung neoplasms, B 11922, C 10502, C 12780, C 12782, C 12783, 8 10988, 8 11394, 8 11774, C 10698, C 10850, C 10939, C 12764, C 12785, C 12786, 8 12394, C 10813, C 10850, C 11246, C 11267, C 11346, C 12787, C 12788, C 12792, C 10939, C 12225, C 12386 C 11387, C 11392, C 11393, C 12793, C 12800, C 12806, occupation as a factor, 8 11505 C 11588, C 11661, C 12224, C 12608, C 128/2 preventive medicine, 11 12133, C 12598, B 1135$', J 10948 tobacco industry liability, B 12504, B 12736, E 12302 neoplasms, 8 11307 1 10821 rocs as a factor, 8 12511 occupation es a factor, 11 11586, tobacco tars and, A 11503 sex as a factor, 8 11375, P 11222 13 11605, 8 12157, /I 12588, tkibercvlosis and, C 11388, smokers vs. nonsmokers, 8 10414, B 12680 C 11874, C 12768 B 10495, 8 21407, 8 12148, sex as a factor, 11 12175 in United Kingdom, B 11604, D 12691 smokers vs. oclamokers, 1 10212, C 10395, J 11264 smoking and, 11 11505, E 11382 11 10270, 8 10365, B 76406, in United States, B 11318, smoking cbaracteriatics and, B 10546, 8 10844, 8 11074, C 10508 8 10494, C 11272, II 10503 B 11300, 8 51877, B 12148, urban-rural influences, statistics, B 10316, B 10415, B 12377, 8 12618,E 10537, 8 10267, 11 11269, 8 11774, 8 10453, 11 10465, 8 10494, E 12296, I 11703, J 12239 B 12609, C 10345, C 10395, 8 10516, B 10821, 8 10915, smoking characteristics and, C 10850, C 11695, C 12226, 8 1097), B 10938, B 11017, C 11272 O 12630 B 11022, 8 11366, B 11375, statistics, 8 10212, B 10290, in Utah, C 11456 11 11469, B 1151n, B 11547, 10295, 11 10316, 11 10415, B 11601, D 11627, B 11916, B 10450, 8 10465, B 10485, 11 11940, 8 12'33, D 12278, B 10601, 8 10623, 11 10624, 8 12281, 8 12346, D 12511, 8 10687, 8 10688, 8 10742, B 12607, 8 12753, D 12816, B 10760,11 10791, B 10828, C 10356, C 10402, C 10466, B 10843, 8 10844, 11 10954, C 10896, C 11456, C 11544, 8 10973, 8 10988, 11 10999, MAMMARY NEOPLASMS, C 11048 C 12274, D 12805, E 11382, 8 11017, 11 11122, B 11133, effect of hormones, A 12665 E 12190, 2 12302, F 11222, 8 11145, 11 11146, B 11115,

experimentally induced, I 12465, .1 11410 8 11234, B 11243, 8 11244, A 10335, A 10862, A 10868, 8 11273, B 11305, 11 11307, 0. 10928, A 10932, A 11001, MORTALITY 8 11312, B 11318, 11 11334, A 11134, A 11139, A 11423, (sae also INFANT MORTALITY; B 11383, B 11425, 8 11426, A 11735, A 1le97, A 11914, MORB1DITY.) 8 11450, 11 11492, D 11498, A 12310, A 12468, A 12469, Age as a factor, C 11668 11511, D 11515, 8 11516, A 12478, A 12719, A 12720 in Colombia, 11 11426 11523, B 11524, 8 11545, smokers vs. nonsmokers, F 11683 effect of smoking, B 10212, 8 11567, 11 11604, B 11627, viral infection and, A 12258 8 10249, 11 10252, D 10515, B 11628, 11 11726, B 11728, 1057, B 10576, 8 10616, 8 11746, b 11785, B 11792, MOISTURE CONTENT 8 10811, 11 1084), 8 11145, 11 11805, 11 11909, B 11916, determination in cigarettes, 11 11299, 8 11383, B 11492, 11 11922, B 11988, B 12034, A 11266 D 11586, 11 11726, 3 11746, 8 12040, B 12117, B 12140, determination in cigarette 11 11836, B 11844, 11 12150, 8 12157, B 12164, 8 12165, smolt*, A 10951 11 12174, 11 12308, B 12324. 3 12174, 8 12175, B 12201, in tobacco leaf, A 11190 3 12348, 8 12477, B 125) B 12236, B 12308, B 12322, tobacco variety and, A 11190 12536, C 10508, C 11566, 11 12324, D 12348, 1 12349, D 10520, D 107)9, 10280, 11 12377, B 12398, 1 12402, MORBIDITY E 11359, E 11654, 11657, 8 12432, B 12519, D 12527, (see also MORTALITY.) B 11695. 11834,E 12246, 12541, B 12542, 11 12551, age as a factor, A 11948, G 11685 10503,I 11560, 8 12658, 8 12757, B 12753, A 12436, 1 11368, 3 11375, I 11623,I' 11700,I 11706, 3 12760, B 12809, 8 12816, 3 11407, 1 11449, 3 11510, 1 11707, 1 11710,1 12836, 10272, C 10402, C 10466, 11 12709, r 11222 J 10383, J 11t11,.1 11121, C 10508, C 10698, C 10909, affect of slaking, A 12704, J 11325, J 11421, J 11568, C 11006, C 11387, C 11456, 8 10252, B 10365, 8 10496, J 11599, J 11687, J 11690, C 11598, C 11661, C 11668, B 10557, B 10616, B 10827, : 11895, J 12370, J 12476, C 12235, C 12466, C 12807, B 11041, $ 11242. B 11299, J 12754 C.12808, C 12829, D 12441, 8 11407, B 11626, b 11644, lung neoplasms, 11 10242, 1 10290, 10645, 8 10604, 1 11004, B 12174, B 12189, 1 125)0, 10295, 8 10375,B 10406, E 11160,E 11259,1 11413, 8 12723, B 12736, D 10739, 10546, B 10617,8 10687, 11654, E 12031,E 12110, 8 12246, F 11222, G 116115, 10821, B 10843,B 10673, 12115, E 12531,It 12759, 1 11623, 1 11700, 1 11706, 10988, 3 10999, B 11074, F 11222, F 12467,11 12619, I 11707, 1 11713, 1 12836, 11147, B 11155, B 11273, B 10503, 1 11703, J 11421 J 10240, J 10383, J 11011, 11383, B 11415,1 11431, in United Kingdom, 11 11516, 11568, J 11622, J 11687, 11604, 11 11628,1 11728 3 11922 11690, J 12754

348 MOBTALITY (Coot'd) MOUTR NEOPLASMS (Cont'd) MYOCARDIAL INFARCT (Cont'd) in United States, 8 11498 hormones and, A 12488 diagnosis, E 10998, E 11338, in India, B 11524, C 11095, E 11434', E 11949 MOON DISEASES C 12002 diet and, E 10304, E 10992, (se also GASTROINTESTINAL localization, C 10523, C 10773, E 12480, E 12746 -)ISEASES; LEUEOPLAKIA; C 10802, C 12459 electrocardiographic effects, MOM NEOPLASMS.) mortality, B 11433, C 11626, E 11443 alcohol consumption end, C 12235, C 12375, C 12832 epidemiology, 8 11569, E 11954, C 12831 pathogenesis, C 12831 E 12289, E 12501, E 12746 areca chewing and, C 12412 predisposing factors, C 10443, etiolnly, D 10214, E 11093 diagnosis, F 12210 C 11402, C 11724, C 11904, heredity as a factor, E 10627, epidamiolugy, P 10864 C 12002, C 12502, C 12597 E 10799 etiology, F 12334 prognosis, A 11936, C 10773, morbidity, 8 11510, E 12223, race as a fact,,r, F 12334, C 11817, C 12375, C 12404 E 12559 J 10578 race u a factor, C 11095, mortality, B 10601, B 11243, smoking and, B 12477, C 10910. C 12235, C 12375 E 12432, E 10266, E 10289, C 11356, C 12412, C 12413, religion as a factor, B 11433, E 10797, E 11254, E 11569, F 10573, F 10574, F 10864, C 12459 E 11730, E 12031, E 12359, F 12198, F 12448, F 12604, sex as a factor, B 11433, J 10948 1 11708, I 10573 C 10431, C 10710, C 10713, occupation as a factor, E 10432, therapy, C 11868, F 12210 C 10750, C 10773, C 10889, P. 10991, E 12501 C 12268 personality as a factor, E 11035, MOUTH MUCOSA smoking and, B 10515, C 10209, E 12501 effect of benz(a)snthracenes, C 10431, C 10523, C 10)73, predisposing factors, 0 10204, A 10774, A 10826, A 11497, C 10049, C 10863, C 10889, E 10271, E 10289, 8 10327, A 11527, A 11616, P 10918 C 10910, C U021, C 11095, E 10619, F 10680, E 11028, effect of benso(a)pyrene, C 11142, C 11356, C 11402, E 11035, E 11362, E 11430, F 11467 C 1159i, C 11771, C 11775, E 11569, E 11634, E 11883, effect of smoking, C 10523, C 12003, C 12152, C 12177, E 12186, E 12455, E 1200.9 C 11021, C 11592, C 11868, C 1226E, C 12309, C 12375, preventive medicine, E 1218r, C 119E4, C 12170, C 12177, C 12413, C 12416, C 12452, prognosis, E 10327, E 11254, C 12591, F 10357, F 10864, C 12459, C 12597, C 12692, E 11927 F 11462, F 12198 C 12835, F 10574, I 11708, race sea factor, 8 11243, effect of tobacco, A 10826, J 11123 E 11408 c 10802 smoking as cause, C 11566, sex as a factor, E 10327, E 10549, smoking clasetficstioo and, C 11626 E 10619, E 10943, E 11408, C 11854 smoking classification and, E 11441, E 12462 tobacco chewing and, C 11021, C 11566, C 11854 smokers vs. nonsmokers, E 11441 C 11252 snuff-dipping and, C 11824, smoking and, 8 11299, B 12324, C 12404, P 10894 10261, I 10327, E 10393, MONTH NEOPLASMS statistics, C 10402, C 10750, 8 10400,E 10514, E 30519, (see also GASTROINTESTINAL C 10983 8 10419, E 10627, E 10845, NEOPLASMS; LIP NEOPLASMS; therapy, A 11986, A 12335, E 10943, E 11028, E 11035, MOM DISEASES.) C 10209, C 10371, C 10480, E 11254, E 11382, E 11569, age as a factor, C 10209, C 10523, C 10710, C 10773, 8 11634, E 11883, E. 11327, C 10710, C 10750, C 12375 C 10863, C 11090, C 11356, E 11954, 1 12186, E 12187, alcohol cone ption and, C 11539, C 11771, C 11775, E 12223, E 12246, i 12)89, C 12835 C 11791, C 11817, C 11824, 12455, E 12475, E 12501, areca chewing and, C 10346, C 11.168, C 12177, C 12215, E 12559, E 12608, E 12746 C 11128, C 12003, C 12459 2 12834, C 12835 smoking as cause, 8 10217, E 10767 areca chewing in etiology of, tobacco chewing and, 8 11524, smoking in etiology of, D 10214, C 11252 C 10196, C 10371, C 10802, E 12552 in Canada, B 11433 C 11021, C 11095, C 11128, stress and, E 11414 case history, C 0480, C 12003, C 12177, C 12413, therapy, E 10304, E 10)27, C 10910, C 11923, C 12268 C 12459, C 12692 E 10797, a 10992, E 11253, diagnosis, A 11986, A 12171, E 11345, a 11430, E 11825, C 10480, C 10889, C 11371, MYOCARDIAL INFARCT 11913, 8 11927, E 11929, C 11775, C 11824, C 11868, (sea also CORONARY dISEASE.) E 12154, E 12559, E 12726, C 12831, C 12832, C 12833, age as a factor, E. 10327, E 12735 C 12834 8 10845, 8 11402, E 11441, urban-rural influences, E 12501 epidemiology, C 10713, C 11564, E 11730, E 12462 C 11771 blood chemical analysis, E 10518, e tiology, C 10915, C 12831 8 10549, R 10902, 8 11634 e xperimentally induced, A 10774, body constitution and, E 11035 A 10859, A 11420, A 11497, case history, 8 12397 A 11527, A 12421, A 12461, A 12488, A 12528, A 12744

349 NASOPHARINGEAL NEOPLASMS NEOPLASMS (Coned) NEOPLASMS (Coned) (sea also RESPIRATORY TRACT C 10830, C 11582, C 11910, occupation as a factor, H 12551, NEOPLASMS.) C 11980, C 12309, C 12807, C 10345, C 10700, C 10896, age as a factor, C 11009, C 12823, 3 11753 C 11126, C 11594, C 11600 C 12668 effect of hormones, A 12574 C 11930, C 12482 case history, C 11603 effect on cell division, A 11339 pathogenesis, A 11339, C 11600 diagnosis, C 11603, C 11665, epidemiology, A 10332, A 10334, in Poland, B 10415, B 11155, C 11908 B 12541, C 10188, C 10196, B 11543 etiology, C 11908, C 11947 C 10272, C 10342, C 10686, predisp5sing factors, C 10188, metastasis of, C 11603, C 11908 C 106)6, C 10897, C 11048, C 10196, C 10272, C 11598, prognosis, C 11603 C 11053, C 11128, C 115E2, C 11750 race as a factor, C 11947 C 11594, C 11600, C 11725, preventive medicine, C 11387, sex as a factor, C 12668 C 11748, C 11970, C 12204, C 11930, C 12295, C 12823, smoking end, H 10515, I 11716 C 12829, C 12833 C 10849, C 11356, C 11665, etiology, A 11114, B 12530, prognosis, B 12322, C 11598, C 12152 C 10299, C 10345, C 10715, C 11920, C 12292 statistics, C 10402, C 11947 C 10772, C 11387, C 11582, in Puerto Rico, C 11904, therapy. C 11356, C 11603, C 11748, C 12432, C 12598 race as a factor, B 11022, C 11665, C 12668 experimentally induced, A 10201, B 11431, B 12322, B 12542, A 10245, A 10441, A 10534, C 10646, C 11544, C 12274, NEONATE A 10706, A 10756, A 10831, C 12482, C 12676, J 12587 (Eel also BIRTH WFIGHT; FETUS; A 10867, A 10900, A 11019, research programs, A 12193, INFANT MORTALITY; PREGNANCY; A 11069, A 11240, A 11339, C 10342, C 10772, C 11960, PREMATURITY.) A 11366, A 11373, A 11483, C 11970, C 12830 effect of bene(s)anthracenes. 11595, A 11640, A 11985, in Russia, C 11960 A 10862, A 11020 A 12000, A 12007, A 12012, sex as a factor, A 12109, B 10485, effect of maternal smoking, A 12024, A 1215C, A 12297, 15 10623, B 10760, B 11273, A 11262, B 11313, F 10461, A 12382, A 12385, A 12470, 11431, B 11602, 8 12322, F 10540, F 10854, F 11351, A 12490, A 12574, A 12577, B 12541, H 12542, C 10356, F 11454, F 11835 A 12583, A 12690, A 12716, C 10909, C 11267, C 11544, effect of nitrosamines, A 10757 C 10618, C 12274, C 12482. C 12677 effect of smoking, F 11263 in Germany, 11 10927 smoking and, A 12704, D 10515, mortality, F 11454 heredity as a factor, A 10339. B 11242, B 11836, 1 12040, A 10534, A 11073, C 11299, 8 12189, 8 12477, C 10188, NEOPLASMS C 10345, C 10189, C 11544, C 10345, C 11048, C 11126, (see also ADENOCARCINOMA; C 11582 C 11544, C 11573, C 11598, CARCINOGENESIS; CARCINOMA; in India, B 10954, B 11017, C 11600, C 11626, C 12212, LEUKEMIA; SARCOMA; and C 12678 C 12482, J 11011, J 11324, specific listing. Ls LONG in Israel, B 11547, C 12204 J 11755 NEOPLASMS; MOUTH NEOPLASMS; iu Italy, A 12040, C 11750 smoking as cause, A 10312, C 10342, etc.) in Japan, C 11009, C 11267 C 11346, I 11722, J 10211, in Afghani/ten, C 11002 metastasis of, A 12577, C 11508, J 11568, J 11690 in Africa, C 10686, C 11776, C 11920, C 12261, C 12409 socioeconomic effects, C 11126, C 12676, J 12587 morbidity, B 10415, II 10873, C 11776 age as a factor, A 12109, II 10988, B 11547, B 12278, in South Africa, 15 11492 B 10623, B 10760, B 11273, B 12281, B 12816, C 10389, statistics, B 10623, D 10624, B 11307, B 11560, B 11602, C 10896, C 10939 10816, B 10843, D 10844, 8 12322, B 12541, 1 12542, mortality, B 10415, b 10485, B 10927, D 10954, 11 11017, 12816, C 10356, C 11009, 11 20515, B 10623, B 10624, B 11022, B 11155, II 11273, C 11267, C 12677, J 11237 11 10760, B 10828, B 10844, B 11307, I 11375, II 11431, air pollution as a factor, B 10873, B 10988, 11 11155, B 11560, B 114n2, b 12281, C 11126, J 11755 B 11234, B 11334, B 11426, C 10156, C 10402, C 11431, in Alaska, C 10646 B 11431, B 11492, B 11498, C 10508, C 10646, C 11002, antigen-antibody reactions in, 11523, B 11560, 11 11567, C 110)6, C 11009, C 11048, A 10441, A 11069, A 11097, B 11746, B 12034, B 12040, C 11267, C 11295, C 11387, A 11640, A 12297, A 12449, B 12281, B 12348, B 12402, C 12003, C 12204, C 12274, A 12716, C 10815 B 12519, 11 12541, 11 12588, C 12676, C 12677, C 12678, aromatic amines in etiology of, 11 12658, 11 12680, 11 12816, J 11237 A 11097 C 10272, C 10646, C 10909, in Seeden. C 10980 arsenic and, C 11860 C 10939, C 11725, C 12807, in Svitserland. b 11273 in Austria, b 10623, 11 10624 C 12829 therapy, A 10201, A 10334, in Borneo, B 11022 in Netherlands. 1 10485 A 11758, A 12012, A 12641, in Bulgaria, D 10915 nitroesmines in st!ology of, C 10272, C 10345, C 10715, in Connecticut, B 10816 A 11.19, A 11125, A 11240, C 11930, C 11960, C 12152, in Csethoelovikia, C 10939 C 10618 diagnosis, A 11889, C 10715,

350 354 NEOPLASMS (Coned) NICOTINE (Coned) NICOTINE (Coned) therapy, C 12309, C 12830, affect on autonomic nervous effect on heart, A 10966, A 11803, J 11753 system, A 10499, A 10625, A 12534, E 10286, E 10885, in United Kingdom, C 11544 A 10708, A 10938, A 10966, E 12200, E 12225, E 12447, in Unitel States, C 10508 A 10976, A 11149, A 11349, E 12796 urban-rural influences, C 11126, A 12182, A 12411, A 12795, effect on heart rate, E 11559, C 12677 E 11559 effect on hormones, A 10363, in USSR, C 10896, C 10897 effect on avoidance learning, A 10836, A 10938 viral infection and, A 12470, 10208, C 10575, C 10588, effect on intestines, A 10489, A 12711, C 10815, C 11960, 11121, C 11555, C 11607, A 10835, A 10836, A 11082, C 12129, C 12830 C 1,609 A 12121, A 12305, A 12329, effect on behavior, A 10331, A 12545, A 12615, A 12727 NEOPLASMS, MULTIPLE PAIMARY, A 10636, A 11556, A 11829, effect on learning, A 11556, C 10389 A 12326, C 10343, C 10385, C i0385, C 12548, C 12549 diagnosis, C 11377, C 12786 C 11081, C 11555, C 12558 effect on lungs, A 10836, smoking and. C 12416 ernt on bladder, A 10967, A 11533 A 12328 effect on morbidity, B 11043 NICKEL effect on blood, t 10840 effect on mortality, E 11559 cercincgenicity, A 10839 effect on blood cholesterol, e ffect on muscles, A 10205, A 10193, A 12155 A 10386, A 10490, A 10812, NICKEL CONTENT effect on blood circulation, A 11149, A 11533, A 11902, determination in cigarette E 10217, E 11250 A 12305, A 12328, A 12411, smoke, A 11531 effect on blood coagulation, A 12534, A 12545, A 12724, E 12027 F 11436 NICOTINE effect cn blood lipids, A 10392, effect on neonate, A 17546 (see also ALKALOIDS, TOBACCO; A 10553, A 11085, A 12155, effect on nervous antes', CATECHOLAM1NES; 001ININE; A .2798, F 11958 A 10556, A 10636, A 10657, "effect of nicotine" under effect on blood platelets, E 10218 A 11066, A 11304, A 11533, BLOOD CHOLESTEROL; and effect on blood pressure, A 1037', A 12446, E 11548 "nicotine and" units' A 10547, A 10609, A 10976, effect on neurons, A 10625, CARDIOVASCULAR DISEASES, A 12113, A 12182, A 12616, A 12546, A 12724, A 12739 CORONARY DISEASE, and E 10286, 0 10385 effect on norepinephrine levels, THROMBOSIS.) effect on blood vessels, A 10205, A 12695 absorption from cigarette A 10631, A 12534 e ffect on peripheral nerves, smoke, A 10834 effect on body weight, A 11037 A 10836, A 11662, A 11882, in arteriosclerosis induction, effect on brain, A 10558, A 10808, C 116E6 A 12155, E 11286 A 10835, A 11550, A 11615, effect on physical fitness, carcinogenicity, A 10831 A 12695, F 12479, C 10208, C 11484 cardiovascular diseases and, 10343, C 11607 effect on prostate, A 10938 E 10217 effect on bronchi, D 11611 effect on respiration, A 10836, determination, A 11850 effect on kardtovascular system, A 11153 distribution in body, A 11066, A 10436, A 11835, A 11080, e ffect on RNA, C 11607 A 11660 A 11896, A 12392 effect on salivation, A 10586 distribution in brain, A 10325 effect on catecholamine e ffect on aerotonin levels, distribution in tissues, A 10558, A 10812, A 11003, A 10561, A 11003, A 11153, A 10325, A 10834, A 11736 A 11770, A 11804, A 12181, A 11808, C 10208 effect on acetylcholine levels, A 12727, A 12737, A 12795, e ffect on sleep, A 10835, A 11304 A 11416, A 11556, A 12616, K 11355, E 11559, C 11636 e ffect on stomach, A 10835, A 12702, A 12224 effect on central nervous system, A 10836, A 12331 effect on acetylcholine A 10378, A 10835, A 10976, e ffect on sweat glands, A 12546 pharmacology, A 10331. A 11003, A 11137, A 11662, effect,a testis, A 10490 A 10373, A 10374, A 10392, A 11853, A 11896, A 12270, effect cn urine, A 12734 A 10545, A 10561, A 10808, C 11348, 0 11686 effect on urogenital system, A 10840, A 1007, A 11149, e ffect on ciliary activity, A 12327 A 11304, A 12121, A 12615, D 10717 effect on uterus, A 11660 2. 12727, C 10343 e ffect on diaphragm, A 10556 effect on vasopressin release. e ffect on adrenal glands, e ffect cr enzyme activity, A 12734 A 10193, A 71804, A 12181, A 10392, A 10840, A 10872, e lectrocardiographic effects, A 12737, E 11548 E 10885 A 11803 e ffect on ascorbic acid levels, e ffect on epinephrine levels, elcctroencephalogrephic effects, A 11576 E 10218, I 11548 A 10499, A 10545, A 10558, effect on autonomic nervous e ffect on esophagus, A 11149 A 10808, A 10835, A 11550, system, A 10331, A 10436, affect on eyes, A 11349 C 10385 e ffect on fetus, A 11262, A 11660, habituation, A 11643, F 11900, 10403, P 10679, P 11698 C 11070, C 11686, J 10349, affect on gastrointestinal tract, habituation in laboratory animals, A 10386, A 10657 C 11081

351 355 NICOTINE (Cont'd) NICOTINE DERIVATIVES (Coned) NICOTINE PHARMACOLOGY ( Cont'd) pharmacology, A 10436, A 10490, effect on nervous system, affect of hexamethonium, A 10545, A 10609, A 10831, A 12446 A 12331, A 12392, A 12739, A 10840, A 11034, A 12181, pharmacology, A 12446 D 11611 A 12270, E 10217, E 12027, structure- activity relationships, effect of hyoscine, A 12113, 10677 A 12758 G 12548 poisoning, A 10837, A 12436, effect of imipramine, A 11003 F 11427 NICOTINE METABOLISM, A 11148 effect of mecamylamine, A 10957, sympathomimetic effects, (see also ALKALOID METABOLISM.) A 10979, A 11304, A 11550 O 11686 biosyneis in tobacco, effect of monoamine °Wise in thrombosis induction, A 10350, A 10522, A 1117D, inhibitors, A 11003 E 12027 A 11205, A 17.594 effect of phencxybenzamine, toxicity, 1 11037, A 11256, degradation in body. A 10325, A 10489, A 10812 A 11541, A 11829, A 11843, A 10834 effect of phentolamine, A 10812 A 12418, A 12704, C 11998 degradation in laboratory effect of physostigmine, A 11149, in urine, A 12567 animals, A 10532 A 12328, A 12724 degradation in liver, 1 10834, effect of proprauolol, A 10489, NICOTINE CONTENT A 12687 A 12392, E 10305 (see also ALKALOID CONTENT; degradation in tobacco, A 11170 effect of quarternary ammonium NORN1COTINE CONTENT.) tobacco variety and, A 11170 compounds, A 11245 brand differences, A 10933, effect of reaerpine, A 10386, A 11059, A 72143, J 10285 NICOTINE METABOLITES A 10489 in cigarettes, A 10222, (see also COTININE.) effect of scopolamine, A 10937, A 11052, A 11361, I 11701, cotinine, A 11148, A 11660, A 11003, A 11082 I 11702, I 11703, I 11719, A 12418, A 12638, A 12667 effect of eerotonin, A 10373 J 10285 fete in body, A 10325, A 11148 effect of tertiary 'minds, A 11145 in cigarette smoke, A 11827, nornicotine, A 12687 effect of tetrodotoxin, A 11082 A 12704, D 10221, I 10581 in urine, A 12567 effect of trizethidinlum, A 10957, determination, A 10837, A 10579 A 11066 NICOTINE PHARMACOLOGY, A 11416, effect of d-tubocurarine, A 11'3, determination in cigarette A 11808, A 11827, A 12545, A 11902 smoke, A 10372, A 10933, A 12695, A 12734, G 12549 research programs, A 10831, A 11059, A 11067, A 11161, effect of acetylcholine, A 10489 A 10835 A 11232, A 11376, A 17368 effect of alkaloids, A 1047 determination in tissues, effect of amines, A 10909 NICOTINE PRECURSORS A 11736 effect of anticonvulsanta, acetates, A 10350, A 12594 determination in tobacco, A 11030, A 11662, A 11853 glutanic acid, A 12594 A 11194 e ffect of antihistaminics, N-methylputreacine, A 10322 determination in tobacco leaf, A 12182 nornicotine, A 12119 A 10312, A 11161, A 11163, effect of atropine, A 10561, A 11193, A 11195, A 11196 A 10657, A 11149, A 11245, NICOTINISM, A 11256 determination in tobacco tars, A 11550, A 11662, A 11804, occupation ss a factor, 1 11845 A 11285 A 12392, A 12615, C 12548 therapy, F 11427, F 11540 effect of cigarette paper, effect of benzo(s)pyreoe, A 12051 A 10332 NITRATES effect of fertilizers, A 11165, effect of cholesterol, E 11286 (see also NITROSAMINES.) A 11166, A 11167, A 11170 effect of cocaine, A 11082 determination in tobacco, effect of moisture, A 11164, effect of cotinine, A 12418 A 11667 A 11165 effect of dimethylphenyl- effect of processing methods, piperssinium salt, A 12411 NITROGEN CONTENT A 10224, A 11173, A 11174, effect of ergot alkaloids, determination in tobacco tars, A 11176, A 11177 A 10547 A 11285 effect of tobacco additives, e ffect of ganglionic-blocking effect of fertilisers, A 11167 A 10224 agents, A 10373, A 10732, In tobacco leaf, A 10313, A 11167, effect on tobacco smoke, A 10938, A 12418, A 12727, A 11169, A 11176, A 11193, E 12228 F 1249, G 12548 A 11194, A 11196 in tobacco leaf, A 10224, effect of guanethidine, A 10489 tobacco variety and, A 11193 A 11169, A 11179 effect of ursicholinium. A 10499, in tobacco smoke, A 10213, A 10966 NITROGEN DIOXIDE A 10224 effect of hexamethodium, A 10489, in air pollution, A 11483, tobacco variety and, A 10224, A 10561, A 10657, A 11066, 1 12329 A 11193 A 11149, A 11245, A 11304, in cigarette smoke, A 10281 A 11615, A 11882, A 12113, determination' is cigarette smoke. NICOTINE DERIVATIVES A 12121, A 12328, A 12329, A 11287 (see also 118TER2 T4o1C NITROGEN effect on lungs, A 10781, COMPOUNDS:PYRIDINES.) A 12093, D 10189, 0 10303, effect on muscles, A 11758 D 10506, D 11158

352 NITROGEN DIOXIDE (Cont'd) NITROSAMINES (Cont'd) OCCUPATIONS (Cont d) ifiact on macrophages, A 12095 in gastrointestinal neoplasm asbestos workers, C 12240, 'hysema and, D 11105 induction, A 10694, A 11483, C 12288, C 12295 Lo,'city, D 10189, D 10505, C 11731 beryllium workers, 8 121.57 D 10506 in kidney neoplasm induction, brick-kiln workers, D 1)326 A 11019, A 11460, A 11530, brick layers, D 12321 NITROGEN OXIDES A 12166, A 12357, A 12363, business executives, E 10250 in cigarette smoke, 1 10281, A 12660, C 10618, C 10945 chemical factory workers, A 11291, determination in cigarette in liver neoplasm inductf,r, C 10278, C 12741, D 11281 smoke, A 11287 A 10251, A 10434, A 10931, clergymen, E 12111 A 11024, A 11097, A 11135, clerks, E 10514, J 11238 NITROSAMINE METABOLISM, A 12540 A 11248, A 11249, A 11270, coal miners, C 11963, D 10566, A 11483, A 11756, A 11934, D 10595, D 1063), D 12015, N1TROSAMINE PHARMACOLOGY, A 11975, A 12108, A 12178, D 12162, D 12543, 8 12343 A 10931, A 11236, A 11757, A 12378, A 12379, A 12380, cotton lint workers, D 11038 A 12509 A 12426, A 12449, A 12509, factory workers, E 10944 effect of 3-methylaholanthrene, A 12601 farm workers, E 10379 A 11530 in lung neoplasm induction, foundry workers, D 12132 A 10895, A 11249 grain handlers, D 10448 h:TROSAMINES metabolism, A 10901, A 12585 hemp workers, D 11673, D 12688 (see also NITRATES.) metabolism in liver, A 11270, industrial workers, C 12103, in bladder neoplasm induction, A 12232, A 12360 C 12104, C 12105, C 12106, A 12287 in neoplasm induction, A 1136f, C 12107, J 12126,1 12127 in brain neoplasm induction, A 11646, A 11757 insulation workers, 8 12588 A 12306, A 12457 in tobacco smoke, A 10229, mete' workers, D 11038 carcinogenicity, A 10245, A 10754 miners, C 10425, C 12762, A 10454, A 10534, A 10585, toxicity, A 12357, A 12601, D 10329, D 10470 A 10755, A 10839, A 10931, A 12812 pitch and tar workers, B 12551, A 11027, A 11125, A 11240, toxicity in laboratory animals, C 11508 A 11549, A 12156, A 12355, A 10434, A 10464, A 10731, policemen, A 12020 A 12357, A 12540, A 12583, A 10895, A 10901, A 10907, railroad workers, C 10418, A 12685, A 12822, C 11789 A 11099, A 12232, D 10867 12501, J 11238 determination, A 10229 rubber workers, C 11225 distribution in organs, A 12585 NOI211C0IINE CONTENT scoria workers, D 11932 effect on cell division, (see also ALKALOID CONTENT; smelter workers, C 11903 F 11309 NICOTINE CONTENT) steel workers, 8 11805, D 12321 effect on cells, A 10398, tobacco variety and, A 11168 telephone workers, E 10870 A 10464, A 10731, A 11756, textile workers, D 11992, A 11934, A 11982, A 12178, NOSE NEOPLASMS E 11303 A 12232, A 12575, D 10867 (see also RESPIRATORY TRACT tobacco factory workers, D 10735, e ffect on central nervous NEOPLASMS.) D 11532, F 11351, 1 11845 system, A 11366 smoking and, C 10700 tobacco field workers, C 10896, effect on DNA, A 10145, P 10548 A 11007, A 11236, A 11270, transportation workers, D 10512 A 11366, A 11549, A 11917, cranium miners, 8 11586, C 11041, A 12306, F 11309 C 11585, C 11632 effect on enzyme activity, vineyard workers, C 11860 A 10901, A 11079, A 11125 OCCUPATIONAL DISEASES, A 11050 wool workers, D 11470 effect on kidneys, A 10464, B 12752, C 12741, . 11470, A 11236 1 11845 effect on liver, A 10398, smoking and, A 12020, C 10401, A 10434, A 10731, A 10901, C 10500, C 10700, C 11041, A 11024, A 11079, A 11236, C 11860, C 12199, C 12212, A 11801, A 11917, A 12449, C 12240, C 12295, C 12762, A 12601 D 10326, D 10329, D 10448, PERSONALITY e ffect on lungs, D 12353 D 10566, D 11038, D 11281, (see 41? tEHAVIOR.) effect on protein metabolism, D 11992, D 12015, D 12162, coronary disease and, 8 11028 A 11125, A 11975, A 12232, D 12321, D 12688 lung meoplasse and, C 12460 A 12360 smoking habit and, C 11113, effect on respiratory tract, OCCUPATIONS C 12460, F 10511, G 10841, A 10754, D 10867 agricultural workers, B 11511, J 10486, J 10599 effect on RNA, A 10245, D 12134 A 10434, A 11236, A 11917 airline steward , P 12163 PESTICIDE RESIDUES effect on trachea, A 10754 asbestos workerr, A 12569, determination in cigarette smoke, in esophageal neoplasm 12680, I 12752, C 10273, A 11531 induction, A 10895, A 11982 C 10401, C 10500, C 10698, determination is tobacco leaf, C 11124, C 11635, C 11818, A 11531

353 357 PHARYCCEAL NEOPLASMS PNEUMOCONIOSIS (Coned) PULMONARY ALVEOLI (see also RESPIRATORY TRACT occupation as a factor, B 12262, effect of ammonia, D 12057 NEOPLASMS.) C 10401, C 10500, C 12288, effect of cigarette smoke, alcohol consumption and, O 10329, D 10470, D 10566, A 11424 C 11386 D 10592, D 10787, D 11274, effect of emphysema, D 12094 areca chewing aui, C 10346 D 12015, D 12162, D 12525 effect of lung diseases, diagnosis, C 11377 smoking and, C 10401, C 12288, D 12056, D 12070 epidemiology, C 11564 D 10329, D 10448, D 10566, effect of smoking, D 11446 etiology, C 10733, C 10815 D 11132, D 11150, D 11992, effect of surfactants, D 12076, mortality, B 11433, B 11524, D 12015, F 10458 D 12722 C 10733 mactophsgee in, A 11424, D 10752, predisposing factors, C 11904 POLONIUM-210 D 11446 smoking and, B 10515, C 10733, in bronchial epithelium. F 10858 oxygen consumption and, 0 12056 C 11386, C 11566, C 12309, bronchial neoplasms and, F 10858 physiology, D 12063, D 12068 C 12452, I 11708 carcinogenicity, A 10839, surfactants in, A 10550, D 10607, smoking as cause, C 11626 A 11723 D 11446, D 12073 statistics, C 10402, C 10980, in cigarette smoke, A 11723 C 11091 distribution in body, A 10231 PULMONARY CLEARANCE therapy, C 10733, C 11091, distribution in organs, A 12474, (see also CILIARY ACTIVITY; C 11386 10858 RESPIRATION; RESPIRATORY distribution in tissues, A 12659 FUNCTION TESTS.) PHENOL CONTENT effect on adrenal glands, A 11468 benzc(a)pyrene, A 11005, F 11247 in cigarette smoke, D 10221 effect on cells, A 11468 effect of smoking, D 10452, determination in tobacco leaf, effect on kidneys, A 12707 D 10977, D 11132, D 11494, A 10310, A 10311, A 10312, pharmacology, A 11987 D 12703 A 10313, A 10314, A 10376, retention in organs, A 12708 mucociliary activity, D 10752, A 11163, A 11195 toxicity, A 12707 D 10779, D 11132, D 11494, effect of fertilizers, A 11188 D 12077, D 12090, D 12091 in tobacco leaf, A 11179, POLONIUM -210 CONTENT particulate matter, A 11005, A 11183 in cigarette smoke, F 10858 D 10452, D 10607, D 10752, tobacco variety and, A 10376 determination in urine, A 11739 D 10779, D 10977, D 11494, smokers vs. nonsmokers, J 10320 D 12065, D 12076, D 12703, PHENOLS in tobacco leaf, A 11012 F 11247 (see also o-AMINOPHENOLS.) polonium-210, A 10231 analysis, A 11064 POLC61UM -210 METABOLISM biosynthesis in tobacco, in laboratory animals, A 12708 PULMONARY FIBROSIS A 10315, A 11012, A 11168 (see also LUNG DISEASES.) in cigarette smoke, A 11064 PREGNANCY, A 11423 diagnosis, D 10444 as cocarcinogens, A 10936 (see also FETUS; NEONATE; experimentally induced, D 12068 determination in cigarette PREMATURITY.) smoking and, D 10444, D 11652, smoke, A 11207, A 11208 effect of carbon monoxide, D 12366 determination in tobacco leaf, F 11697 A 13376 effect of cigarette smoke, PULMONARY HEART DISEASE, F 10800 effect on hydroxylase activi.y, F 10854, F 11263 (see also HEART DISEASES.) A 11025 effect of maternal smoking, diagnosis, D 10801, E 11953, formation in carboxylic acids B 12189, B 12477, E 11283, D 12080, E 12082, E 12383 pyrolysis, A 11064 F 10461, F 10540, F 10621, experimentally induced, E 12083 metabolism, A 10260 F 10747, F 10853, F 10854, lung diseases and, C 11969, in tobacco leaf, A 12712 11226, F 11395, F 11454, D 10817, D 12064, D 12070, in tobacco smoke, A 12712 F 11697, F 11835 E 1195, E 12523 effect of nicotine, A 11148 oxygen consumption and, E 12061, PHYSICAL FITNESS E 12062 effect of carbon monoxide, PREMATURITY smoking And, D 105'-, D 11438, F 11678 (sea also FETUS; NEONATE; E 11952, E 1195. E 12523 PREGNANCY.) therapy, E 11953 ?toO0 7s. TOBACCO effect of maternal smoking, analysis, A 11168 A 11262, F 10361, F 10403, PYRIDINES, A 12119 effect of fertilisers, A 11168 F 10540, F 10621, F 10747, (Lee also, HETEROCYCLIC NITROGEN F 10854, F 11226, F 11351 COMPOUNDS; DERIVATIVES.) PNEUMOCONIOSIS, D 12840 carcinogenicity, A 11255 (me also RESPIRATORY TRACT PULWRARY ALVEOLAR PROTEINOSIS determination in cigarette DISEASES.) (see also RESPIRATORY TRACT smoke, A 11201 experimentally !minced, DISEASES.) determination in cigar smoke, D 11105 pathogenesis, D 10891 A 11201 smoking and, D 10891

354 35se REDUCTION OP SMOKING RESPIRATORY INSUFFICIENCY (Cont') RESPIRATORY TRACT NEOPLASMS (see also CESSATION OP SMOKING; smoking and, D 10468, D 10535, (see also BRONCHIAL NEOPLASMS; WITHDRAWAL CLINICS.) D 10965, D 12018, D 12037 LARYNGEAL NEOPLASMS; LUNG antismoking campaigns and, therapy, D 10468, D 11288, NEOPLASMS; NASOPHARINGEAL J 10622, J 12444 E 11458 NEOPLASMS; NOSE NEOPLASMS; behavior therapy, K 10504, PEARYNCEAL NEOPLASMS; K 10516, K 10519, K 10579, RESPIRATORY TRACT DISEASES RESPIRATORY TRACT DISEASES; K 11412 (see also ASTHMA; CHRONIC TRACHEAL NEOPLASMS.) drug therapy, K 10525 BRONCHOPULMONARY DISEASE; air pollution as a fa.:tcr, methods, A 11361, J 11336, COUCH; LARYNGEAL NEOPLASMS; ,1 10699, C 10700 K 11412, K 12036, K 12387 LUNG DISEASES; PNEUMOCONIOSIS; aromatic hydrocarbons in reinforcement (psychology) in, PULMONARY ALVEOLAR PRO - etiology of, A 10336, C 11051 K 10516 TEINOSIS; RESPIRATORY arsenic and, C 11903 role of physicians, J 12442, INSUFFICIENCY; :1ESPIR,TORY experimentally induced, A 10336, K 11507 TRACT NEOPLASMS; TUBFRCULOSIS.) A 10454, A 10859, A 11589 age as a factor, D 10468, mortality, B 10624, B 10791, RESPIRATION D 10513, D 10724, D 11293, B 11586 (see also PULMONARY CLEARANCE; D 11907 occupation as a factor, C 11594, RESPIRATORY FUNCTION TESTS.) air pollution as a factor, C 11903 effect of smoking, D 10559 12752, D 10247, D 10448, smoking and, A 10474, C 10699, D 10513, D 10882, D 11293, C 10700, C 11051, C 11416 RESPIRATORY FUNCTION TESTS, D 11294, D 11470, D 11879, statistics, B 10624, B 10816, D 10775, D 11010. D 11109, D 11907, D 12132 B 11547 D 11230, D 11251, D 11438, cough and, C 12767, D 10751, D 11682, D 11684, D 11699, D 11293, D 11294 D 12088, D 12162, D 12168, diagnosis, D 12074, D 12840 D 12487, E 12255 electrocardiographic effects, (see also LUNG FUNCTION; D 10512 PULMONARY CLEARANCE; epidemiology, D 11294 RESPIRATICV.) experimentally induced, D 12078 SAFE CIGARETTES, A 11502, J 11321, age as a factor, A 10771, in India, B 11449 1 11324, J 11327 D 10482, D 11150, D 11341, morbidity, B 11558, B 12278, cot,ustion temperature and, D 11673, D 12231, D 12688 D 10724, D 11907, E 10457 A 10577 effect of acetylcholine, D 11767 mortality, B 10742, B 11498, evalust1 a, B 10242, J 10211, effect of smoking, D 10200, B 11516, B 11567, B 11627, J 10240, 1 10405 D 10329, D 10551, D 10594, B 12174, D 10724 filters and, A 10237, A 10415, D 10884, D 11347, D 11494, occupation as a factor, D 11247, A 10892, A 11200, A 11501, D 12539, D 12543, D 12689, D 10735, 0 11470, D 11532, C 10216, J 11688 L 10600 D 12132, 0 12134, D 12406 nicotine content ani, A 12184, equipment, A 10771, D 10743, pesticide residues and, D 11618 E 12228, I 11322, J 11323 D 12078 research programs, C 11957, pesticide residues and, J 11688 in laboratory animals, D 11302 D 12054, 0 12840 by processing modification, method., D 12058, D 12059, in Russia, C 11874 A 10226, A 10435, A 10580, D 12066, D 12069, D 12070, smoking and, B 12189, D 10247, A 10871, A 10947, A 11051, D 12079, D 12081, D 12086, D 10329, D 10448, D 10724, A 11465, A 11501, A 12242, D 12093, D 12099, D 12100 D 10865, D 10882, D 11293, 7 10211 occupation as a factor, V 11294, D 11618, D 11879, h programs, A 11501, D 10512, D 10596, D 10801, D 12132, D 12231, D 12406, A 12599, 8 12618, C 11389, D 11624, D 11673, D 12543, F 11469 7 10211, J 10320, J 11687, D 12688, E 10944 'stoking as cause, 10474, J 11618, J 12429 . ex as a factor, D 10482 B 11242, 8 11299, C 11346, tar c "ntent snl, I 11322, e voker. vs. nonsmokers, A 10771, D 11268, D 12026, J 10320, I 11554, J 11323 D 10381, D 10448, D 10801, J 11690 tobacco substitutes, A 10940, D 10942, D 10969, D 11150, statistics, B 10954, B 11375, A 11014, A 11501 D 11231, D 11268, D 11281, D 10724 D 11306, D 11341, D 11624, therapy, D 10865, 0 12840, SAROOMA D 11673, 0 12231, D 12275, E 11458 (see also NEOPLASMS.) D 12688, 1 10498 in Yugoslavia, D 12134 experimentally induced, A 10203, A 10251, A 10567, RESPIRATORY /NSUFFICIENC, C 11350 RESPIRATORY TRACT INFECTIONS A 110I8, A : 19, A 11069, (gee also RESPIRATORY TRACT effect on smokers, D 12691 A 11076, A 11v77, A 11360, DISEASES.) smoking and, D 11942, 1 10498 A 11366, A 11460, A 11630, chronic btonchopulmonary A 11823, A 11885, A 11936, and, D 11590 A 11937, A 12160, A 12257, diagnosis, D 11590 A 12522, A 12595, A 12596, e ffect of respiratory tract A 12624, A 12826 discus., D 10965, D 11230

355 5519 SARCOMA (Cont'd) EMCEE, CIGARETTE (Cont'd) SMOKE, CIGARETTE (Cont'd) in laboratory animals, A 11630 carcinogenicity, A 10303, tar content, A 12520 metastasis of, A 11630 A 10428, A 10585, A 10831, toxicity, A 10831, A 11037, therapy, A 12570, A 12656 carcinogenicity, A 10859, A 11956, A 12599, A 12633, A 11786, A 12638 C 11998, D 11260, F 11263 SCOPOLIN carcinogens in, J 11753 unstable species in, A 10230, bioeynthesis in tobacco, distribution in lungs, D 12797 A 10281, A 10634, A 11228 A 11013 effect of tobacco additives, A 11210 SINKERS VS. NONSMOKERS, D 11446 SELENIUM effect on blood, A 10281, attitudes, I 11709, J 10394, determination in blood, D 12205 J 11692, J 12141, J 12725, A 12401 effect on brain, F 10462 K 10529 distribution in organs, effect on bronchi, D 11611 behavior, J 12141 A 12399, F 12273 effect no bronchial epithelium, blood chemical analysis, affect on liver, F 11445 D 10220 A 10384, A 11461, A 11780, mechanism of action, A 10079, effect on carbohydrate E 10612, E 12205 A 10905, A 10961, A 12401 metabolism, A 11297 bled cyanide levels, A 12532 metabolism, A 12342, A 12401, effect on cells, A 10476, blond thiocyanate levels, F 11445 A 10964, A 11229, A 11297, F 10893 as therapy, F 11445 A 12573, A 12633, D 10220, body constitution, E 10190 toxicity, A 10905, A 10912, D 10598 effect of air pollutants, A 10961 effect on cilia, A 11229 B 11480, D 10326 effect on ciliary activity, morbidity, C 10380, D 10637, SKIN NEOPLASMS A 10838, D 10221 D 11268 (see also CARCINOMA, effect on entyme activity, respiratory function tests, EPIDERMOID.) A 10872, A 11866, A 12602, D 10724, D 12339 experimentally induced, A 12747, A 12798 sputum analysis, A 11493, A 10396, A 10397, A 10399, effect on heart rate, A 10583, A 12472, C 10763, C 11744, A 10492, A 10531, A 10534, A 12439, E 10248, F 10462 D 11481, D 12026 A 10577, A 10962, A 11491, effect on histamine levels, urinalysis in, P 11261, F 11517 A 11503, A 11535, A 11589, A 10323, A 10781, A 11493, A 11786, A 12011, A 12122, A 11772 SMOKE STREAMS A 12124, A 12135, A 12817, effect on kidneys, A 10964 (Used only for mainstream and/or A 12837, C 10219 affect on lung function, D 10779 sidestream fraction(s) of inhibition, A 10397, A 10399 effect on lungs, A 10577, A 10781, tobacco smoke.) metastasis of, C 11509 A 11964, A 11297, A 11298, aldehydes in, A 10323, A 10474 occupation as a factor, A 11981, A 11889, D 10719, analysis, A 10778, A 11184, C 11508, C 11594 D 12722 A 11228, A 11372, A 11421, pathogenesis, C 12239 effect on macrophages, A 11424 A 21663 predisposing factors, C 1004 effect on microorganisms, tat content, D 10221 therapy, C 11509 A 10840 toxicity, C 11151 tobacco tars and, A 11503 effect on mucociliary activity, D 10293, D 10717 SMOKE, TOBACCO SMOKE, CIGAR effect on mucus, A 10838, (see also SMOKING; SMOKING, PIPE.) (sea also SMOKING, CIGAR.) D 10779 allergy, D 11532, T 11796 analysis, A 10254, A 11199, effect on nervous system, amino acids in, A 11465 A 11201 F 11436 analysis, A 11184, A 12314, carcinogenicity, A 11786 effect on respiration, A 11153 A 12340, A 12356, J 11690 tar content, A 11199 effect on respiratory tract, carcinogenicity, A 10832, A 10235, A 10838, A 12568, A 11837 SMOKE, CIGARETTE A 12573 effect of antioxidants, A 11465 (see also BRONCHIAL effect on trachea, A 10838, effect on air pollution, A 12731 EPITHELIUM; SMOKING.) D 10598 effect on amino acids, A 10384 alicyclic hydrocarbons in, effect on vitamin levels, A 12453 effect on ascorbic acid levels, A 10952 filtration, A 10225, A 10237, A 10455, A 10340, A 11576, allergy, D 12434, F 11760 A 10238, A 10833, A 10964, A 12453, F 11517 analysis, A 10229, A 10233, A 11197, A 11198, A 11200, effect on blood cells, A 12472 A 10234, A 10235, A 10353, A 11211, A 11212, A 12048, effect on lunge, A 12114 A 10372, A 10408, A 10833, A 12053 effect on macrophages, A 11465 A 10908, A 10949, A 10953, gas phase separation, A 11211, effect on nonsmokers, A 10631, A 11161, A 11201, A 11202, A 11212 8 11407, D 10513, D 12434, A 11204, A 11228, A 11264, hydrogen ion concentration, F 11089, J 11310, J 12351, A 11287, A 11422, A 11500, A 12048 J 1204, J 12718, J 12803, A 11663, A 12045, A 12520 inhalation, A 11474 J 12812 brand differen.xes, A 126F1, particulate phase separation, effect on organs, A 10832 A 12682 A 11013, A 11211, A 11212 effect on pulmonary clearance, polonium -210 content, A 1)231 F 11040

356 SMOKE, TOBACCO (Coned) SMOKING (Co) SMOKIK." (Coned) effect on respiratory tract, effect on bronchi, ') 10293, effect on mucous membrane, A 10839 D 10719, D 10721 C 10849, D 10718, D 10739, effects during pregnancy, effect on bronchial epithelium, D 11141, D 11672 J 12812 C 10156, C 11777 effectcri muscles, A 10583, inhalation, A 11153, A 12184, effect on cncboxyhemoglobin F 10498, F 11436 A 12439, B 11383, B 11836, F 10517 effect on nervous system, L 10436, P 12304, F 12448, G !1072 effect on cardiovascular systeo, A 12270, F 10890 pesticide residues in, A :0207, E 10767, E 11752, E 11884, effect on nonsmokers, C 11693, A 10950, A 11742, E 11053 E 12395 E 12395 radioactive particles in, effect on catecholamine levels, effect on norepinephrine levels, A 10231 A 12606, F 12304 L 10583, A 11084 toxicity, A 10235, A '0832, effect on cell division, effect on organs, F 11451 J 12803 C 11669 effect on oxygen consumption, unstable species in, A 12427 effect on cells, A 10292, F 11783 A 11956, A 12472, A 12811, effect on perception, F 10517 SMOKING C 10830, C 11272, D 11749, effect on phys:cal fitness, (Used for cigarette smoking, D 12026, F 11263 B 12280, E 10612, E 12585, unspecified, and mixed effect on central nervous system, F 10511, P 11678, G 11340, smoking. See also SMOKE, A 10378 J 12316 CIGARETTE; SMOKE, TOBACCO; effect on coronary vessels, effect on protein metabolism, SNUFF-DIPPING; TOBACCO E 10542, E 11561 A 11424 CHEWING.See also effect on enzyme activity, effect on pulmonary alveoli, CATECHOLAMINESI-wiffect of A 10194, A 10384, A 10476, E 10600 smoking" under BRONCHIAL A 10532, A 11065, A 11461, effect on pulmonary clearance, EPITHELIUM; BLOOD LIPIDS; and F 11436 D 11942 "smoking and", "smoking in effect on epinephrine levels, effect on respiratory tract, etiology of" and "smoking as A 10583, A 11084 D 10735, D 10739, D 11942 cat....e" under CORONARY effect on equilibrium, A 11829, effect on senvation, C 10284 DISEASE, LUNG NEOPLASMS, etc.) F 11861 effect on sensory organs, absenteeism and, B 10252, effect on fertility, A 11262, D 12759, F 12561 B 10270, B 10494, B 10827, A 13956, A 12811, F 10853, effect on taste, F 10574, G 11686 B 11940, B 12148, N 10503 F 11263, F 11683, F 11931, effect on testis, F 11263 I 11713, J 11557, J 11637, F 12220, F 12304 effect on tissues, A 12439, J 12126 efect on gastric cidity, F 11872 F 12604 accidents and, P 10297 effect on gastric lemma, F 10493 effect on urine, A 11782, A 12567 age as a factor, A 10708, effect on gastrointestinal tract, effect on mogenital system, D 12759 F 10498, F 10692, F 11221, C 11950 arteriosclerosis and, A 10777 F 11872 effect on vision, F 10297, as cause of bronchogenic effect on gingiva, F 11629 F 10433, F 10956, F 10924 carcinoma, J 10728 effect on heart, J 1067i effect on vitamin levels, A 10435, as cause of lung neoplasms, effect on heart function, E 11432 A 11576, C 11272, F 11261, C 11642 effect on heart rate, E 10248, F 11517 cough and, D 10615 E 11752, E 12451, F 10924, electrocardiographic effects, effect on adrenal glands, F 11678 E 10612, E 10620, E 11752, A 1019 3 effect on hemoglobin levels, E 11794 effect on air pollution, A 10281, C 11272 electroencephalographic effects, B 10252 effect on larynx, B 11505, E 12451, F 11490 effect on blood, A 11780, C 10849 emphysema and, D 10719 D 10330, E 10286, E 10600, effect on liver, C 10430 habituation, G 11685, C 11686, E 11659, P 11221 effect on lungs, C 11642, G 12191 effect on blood Cholesterol, D 10220, D 10294, D 10330, in laboratory animals, A 19292, C 10921, E 10261 D 10716, D 10718, D 10739, A 10428, A 11486, A 11881, effect on blood coagulation, 1 11705, I 11712 A 12681, E 11884, G 10632 D 11729, E 10218, E 11679 effect on macrophages, D 10752, in lung neoplasm etiology, B 1q613 e ffect on blood lipoproteins, D 11446 luz4 neoplasm and, J 10677 A 10384, E 10261, F 11000 effect on morbidity, B 10495, in multiple sclerosis etiology, e ffect on blood pressure, F 11900, J 10613, J 10674, F 12693 E 10261, F 10370 J 10728 in neoplasm etiology, C 1094S effect on blood vessels, effect in mortality, B 12175, prohibition, B 10557, J 10282, A 10638, E 11561, 11919 8 123/7, J 10673 J 10703, J 11310, J 11329, effect on body temperature, effect on mouth, A 12633, F 11462, J 11435, J 11670, J 12493, A 10583, A 10631, A 12439, F 11919, I 11708 J 12718, J 1273), J 12802, E 10198, E 10888, F 10924 J 12803, J 12812 effect on brain, A 11131 sex as a factor, A 12326, F 12220 taxation, J 11418

357 341 SMOKING CHARACTERISTICS SMOKING HABIT (Cont'd) SMOKING HABIT (Cont'd) (see also BEHAVIOR.) antismoking campaignsand, knowledge of health facts and, cardiovascular diseases and, B 10242, C 12505, J10459, I 11704, J 10766, J 11129, E 10217 J 10536, J 11107, J11325, J 11565, J 12814 effect on cessation of smoking, J 11326, J 11327, J11329, in lung neoplasm etiology, J 10407 J 12331, J 11344, J11419, B 10496 effect on mortality, B 10844 11579, J 12623, J12624, medical sildents, J 11419, evaluation, E 10196, J 10388, J 12625, J 12626, J12627, K 11258 J 11045 J 12628, J 12629, J12630 modification, K 11495, K 12387 nicotine absorption and, attitudes, C 10668, C12505, in Norway, C 12005 F 11678 J 10253, J 10258, J10387, occupation as a factor, B 11505, in United Kingdom, J 11448 J 10388, J 10394, J10459, L 22688, J 10459, J 11993, J 10491, J 10530, J10666, J 12:26, J 12127, J 12336 SMOKING, CIGAR J 11238, J 11319, J11320, peer group influences, J 12538, (see also SMOKE, CIGAR; J 11384, J 11993, J12151, J 12626, J 12843 SNUFF-DIPPING; TOBACCO J 12176, J 12537, J12563, personality as a factor, C 12371, CHEWING.) J 12612, J 12718, J12725, E 10190, G 10302, G 10639, in neoplasm etiology, C 10945 J 12821 C 10665, G 10671, C 11072, behavior and, A 10562, C 10667, I 11704, .1 10391, J 11622, SMOKING CLASSIFICATION C 10668, C 11669, C 10672, J 11692, J 12373, J 12422, age as a factor, J 11520, C 10841, C 11072, C 11691, J 12429, K 10579 J 11521 J 11390, J 10911, J 11328, physftians, A 12330, B 10576, effect on morbidity, E 10213, J 11538, J 12611, J 12612, B 11383, G 10274, J 10244, J 10674 K 10529 J 10536, J 10569, J 10602, effect on morta11,1, B 10844, behavior therapy, C 11685, J 10790, J 11086, .1 11235, B 12150, J 11 11 J 10391, K 10382, K 10579, J 11637, J 12176, J 12821 neoplasm local's. ;ion K 12610 psychosocial aspects, G 10665, C 10523, C 11788, C 12152 ballet in smoking hazards, C 11340, J 10391, J 10486, physicians. J 11448 C 10665, J 10253, J 10341, J 12422, J 12538, J 12705, statistics, B 10844, J 11045 J 11419, J 11637, J 11643 K 10529 in United Kingdom, J 11446 body constitution and, E 10190, race as factor, J 10578, C 10302 J 12151 SMOKING HABIT in Canada, J 10285 reason, for, A 10378, A 10562, absenteeism and, J 11935 cognitive dissonance and, 12618, G 10639, G 10667, academic achievement and, C 10274, C 10668, C 10798 C 10668, C 11070, G 11072, G 11698, J 10407 in Connecticut, J 12517 C 11685, C 11686, G 11698, age as factor, G 10669, Jefense of, n 10375, B 10496, I 11704, I 11709, I 11713, G 12505, J 10253, J 10258, C 10538, C 10274, I 11488, J 10360, J 10463, J 10491, J 10386, J 10394, J 10427, J 10997, J 11060, J 12425, J 10530, J 10666, J 106'4, J 10463, J 10509, J 10530, J 11801 J 10676, J 10806, J 10842, J 10599, J 10602, J 10728, diet tad, F 10890 J 10948, J 10984, J 11138, J 10744, J 10766, J 10974, effect of advertising, 1 11689, J 11319, J 11320, J 11328, J 10984, J 11036, J 11131, I 11709, J 10387, J 10984, .1 11384, J 11522, .1 11565, J 11138, J 11277, J 11330, J 11599, J 11688, J11692 J 11579, J 11599, J 11690, J 11331, J 11384, J 11410, effect of learning, J10e02 J 11692, J 1'806, J 12250, J 11504, J 11520, J 11521, effect of nicotine, G11686 J 12284, J 11422, J 12498, J 11577, J 11579, J 11644, effect of parental smoki-.-, J 12537, J 12560, J 12592, J 11802, J 11935, J 12004, G 10669, J 10258, J 10.16, J 12611, J 12627, J 12628, J 12118, ! 12159, J 12250, J 10388, J 10427, J 10497, J 12705, J 12814, K 10)61 11184, J 12516, J 12517, J 10727, J 10728, J 10766, religion as a factar. B 11143, J 12537, J 22538, J 12547, J 11277, J 11577, .1 11579, 11304 J 12592, J 12611, J 12612, J 12538, J 12843 h programs, G 10798, J 12623, J 12624, J 12626, effect on body weight, J 12127 G 11685, 0 11698, J 10658, J 12627, J 12618, J 12629, effect on oxygen consumption, J 12628, K 12590 J 12630, J 12705, J 12718, F 12301 sex as a factor, A 12472, J 12725, J 12733, J 12814 In German), C 12505 G 10639, C 10669, J 10253, alcohol consumption and, heredity as a factor, A 12472, J 1:1427, J 10599, J 10602, B 11505, C 10910, C 11775, D 10616, C 11656, E 10190, .1 10)74, J 11036, J 11277, D 10475, E 10262, E 10886, F 11047, G 10841, J 12373 J 11384, J 11410, J 11577, F 10297, F 10317, F 10856, history, G 11686, J 10321, J 11622, J 12118, J 12151, G 10274, J 10911, J 11218, J 10677, J 10736, J 11435, J 12159, J 12538, J 12547, J 11802, J 12705 J 11690, J 12197, J 12336, .1 12612 in American Indians, J 12644 J 12644 in Italy, J 11577 juvenile delinquency and, J 11802

358 3620 SMOKING HABIT (Cont'd) SMOKING, MATERNAL (Cont'di SKOR'NG SURVEYS (Cont'd) socioeconoec effects, F 11454, effects during pregnancy, in United States, B 12377, J 10258, J 10427, J 10578, A 10377, A 11102, A 11503, J 10215, J 10387, J 10391, J 10599, J 11036, J 11238, A 11353, A 11660, A 12602, J 10647, J 10974, J 11410, J 11692, J 12560, K 10529 F 10361, F 10370, F 10621, J 12547 in South Africa, C 12374 I 10679, F 11395, F 1176, to Utah, C 11456 stetiatics, B 10375, J 10744, F 1165', F 11683, F 11898, J 12621, J 11644 F 11899, F 11931, F 12220, SNUFF-DIPPING, J 7.1328 stress and, C 12371, 1 12395, F 12486, J 10727 (um also SMOKING; SMOKING, G 11072, J '0360, J 12429 CIGAR; SMOKING, PIPE.) in United Kingdom, 8 10242, WOKING, PIPE naaopbaryngeal neoplesms and, J 10253, J 11275, J (see also SMGKE, TOBACCO; F 10894 J 11521, J 12560 SNUFF - DIPPING; TOBACCO CHFW in United States, J 10744, LNG.) STATISTICAL ANALYSIS, 11 11746, J 11621, J 12537 in neoplasm etiology, C 21-45 B 11916, B :2541, C 11676, C 11694, B 11378, I 12188, SMOKING AND HEALTH SMOKING SURVEYS, G 11341, J 11935 E 12;59, F 11678, I 11715, directory, J 11680 in Arizona, J 10394 I 11716, I 11719, I 11722, evaluation, A 10231, A 11837, in Australia, J 12612 J 11129, J 11421 B 10365, B 10494, B 10616, in California, J 11129, K 11258 evaluation, J 11688 C 11642, I 11706, I 11713, in Canada, J 11384 methods, C 11295, C 11632, 1 11715, 1 11716, I 11717, in Connecticut, J 10459, J 11237, J 11846 1 11719, I 11720, I 11721, J 12516 1 11722, I 12836, J 10211, dentists, J 10647 STEROIDS J 10349, J 10673, J 10674, evaluation, J 11045, J 11737 chronic bronchopulsonary disease J 10675, J 10677, J 10678, follow-up studies, G 10669, and, D 11109 J 11060, J 11647, J 11687, J 11993, J 11994 effect of benz(a)anthracenes, J 11688, J 11690, J 11734, in Germany, J 11218 A 11489 J 12476 in Illinois, J 10407, J 10880 effect on respiratory tract, Michigan Council on S't.ing in Ireland, ! 10218 A 12666 and Health, J 10814 In Italy, J 11036, J 11577, in urine, F 11473 National Inter-Agency Council, J 12127 J 10792, K 11810 in Japan, C 10419 STEROLS h programs, B 12477, medical students, J 11419, K 11258 biosynthesis in tobacco, A 11012 E 10612, E 11884, G 10671, in Michigan, J 11419, J 11579 A 11961 J 10405, J 10622, J 10658, in New York, J 10390 carcinogenicity, C 10921 J 10673, J 10675, J 10678, in Norway, J 11045 in tobacco leaf, A 12046 J 11011, J 11641, J 11761, physicians, J 10459, J 10536, J 11886, J 12004, J 12141 J 10569, J 10571, J 10790, STOMACH NEOPLASMS statistics, B 10494, B 11147, J 11448, J 11991, J 12821 (see also GASTROINTESTINAL 11100, H 10503, J 10530, in Poland, J 10427, J 11277 NEOPLASNS.) J 10673, J 10674, J 10675, in Rhone Island, J 11487, J 11994 in Czechoslovakia, 8 11450 J 12423 in schools, D 12759, G 10665, diet and, B 11450 J 10669, G 11698, 1 10653, epideaiology, C 11573 SMOKING MACHINES, A 10614, I 11701, 1 11711, J 10253, experimentally induced, A 10694 A 10964, A 11474, A 11486, J 10258, J 10276, J 10388, mortality, 8 11450, B 11545 A 12535, D 10330, G 10632, J 10394, J 10407, J 10427, smoking and, 8 11450 J 10502 J 10491, J 10509, J 10530, snuff - dipping and, C 12591 in cigarette smote analysis, J 10599, J 10666, J 10727, statistics, B 10915 A 10372, A 10634, A 10778, J Inns, J 10766, J 10880, tobacco awing and, C 12591 A 11141, A 11206, A 1'207, J 1.036, J 11129, J 11277, urban-rural influences, D 11545 A 11211, A 11228, A 11232, J 11331, J 11384, J 11487, A 11264, A 11297, A 12052 J 11520, J 11521, J 11577, J 11579, J 11644, J 11806, SMOKING, MATERIAL J 12004, J 12118, J 12151, effect on birth weigh:, J 12159, J 12250, J 12423, F 10679, F 11651 J 12516, J 12538, J 12611, e ffect on fetus, F 10370, J 12412, J 12733 F 11683 in Sweden, J 12821 TAR CONTENT effect on hydroxylsse activity, in twins, I 11716 brand differences, A 10933, F 12486 is United Kingdom, B 10546, A 11059, A 12443, J 10285 e ffect on prematurity, F 10679, F 11454, G 14642, 1 10653, in cigarettes, A 10222, A 11052, F 11651 J 102'3, J 11238, J 1144: A 11361,1 11453,I 11701, J 11520, J 11521, J 11993, I 11702,I 11703,I 11719, J 12584 J 10215,J 10285

359 543 TAR CONTENT (Cont'd) TERPENES TOBACCO (Cont'd) in cigarette smoke, I 10581, biosynthesis in totacco, A 12632 carcinogenicity, A 12011, C 10291, J 11380 C 10815 determination in cigarette TERPENOIDS consumption, 11 10483, J 11211 smoke, A 10372, A 10933, determination in tobacco, A 11187 effect of fertilizers, A 11162 A 11059, A 11232, A 12368 in tobacco leaf, A 12632 effect of pesticide residues, effect of cigarette paper, A 12763 A 12051 TH1OCYANATES effect of processing methods, effect of processing methods, (see also CYANIDES.) A 12202 A 10226 in blood, F 10890 effect on fetus. A 11761 effect of smoking in saliva, C 10855 effect on gastric mucosa, A 10411 characteristics, J 10215 in urine, A 10840 effect on liver, F 10548 effect of tobacco additives, pesticide moldy...Ls inA 10207, A 12049 THROMBOANG1ITIS OBLITERANO A 10210, A 10950 legislation, 1 11453 (see also ARTERIAL DISEASES; production, A 10202, A 11173, physical properties of THROMBOSIS.) A 11174, A 11175, A 10176, cigarettes and, A 10222 age as a factor, E 10642, S 11379 A 11177, A 11178, A 11181. in tobacco smoke, A 10223 arteriosclerosis and, E 10642, A 11189, A 11190, A 11196 E 11379, E 11439, E 11537, research programa, A 10402, TARS, CIGARETTE E 11674, E 12510 A 10826, A 11161, A 11172, (see also GAS PHASE, case history, E 11379, B 12347 A 11181, A 11182, A 11188, CIGARETTE SMOKE.) diagnosis, E 1. E 11537, A 11189, A 11196, A 12696, analysis, A 10935, A 10937, E 11674, E 12510 A 12697 A 11067, A 11161, A 11202, pathogenesis, E 10;37, E 11044, statistics, 6 12536, H 10483, A 11203, A 11205, A 11531, E 11439, E 11945 H 11215, H 11216 A 11955, A 12620, A 12461, predisposing factors, E 11546 sugar content, A 12508, A 11681, A 12760 prognosis, E 10308, E 12507, A 12682 carcinogenicity, A 10239, E 12510 as therapy, A 12330, E 11443, A 10577, A 10585, A 10631, smoking and, E 10308, E 10477, F 11217, J 10736 A 1Ud09, A 10936, A 11503, E 10642, E 10887, E 11044, toxicity, A 11256, A 11541, A 12619, A 12620, A 12686, E 11241, E 11379, E 11439, A 11948, A 12636, A 12763, A 12837 E 11546, E 12507, E 12510 B 10821, C 10699, J 12622 Effect on bronchial epithelium, smoking as cause, E 11674, A 12663 E 1/445 TOBACCO ADOITEVES effect to cells, A 11787 smoking in etiology of, E 10848 (e ale GLYCERIN; GLYCOLS; effect to cilia, A 12683 therapy, E 10308, E 10477, SUMECTANTS6 effect ciliary activity, E 10737, E 10887, E 11537, analysis, A 10202, A 11210, D 10211 E 12347, E 12507, E 12510 A 12180 Wee. to lungs, A :26E6 cellulose, A 112t0 filtration, A 11197 THROMBOSIS, 8 10546, E 10824, in cigarette smoke, A 11;42 moisture content, A 10951 E 11088, 1 12082, E 12083, effect on carcinogenesis, A 11061 nicotine content, A 11067, E 12383, 1 12397, E 12523 effect on conbustion temperature, A 11285 (MI also CARDIOVASCULAR A 12340 is skin neoplasm induction, DISEASES; CEREBRAL EMDBLISM effect on smoke, A 10871, A 10947, A 11552, A 11905 and THROMBOSIS; CORONARY A 11210, A 12340 DISEASE; THROMBOANGIITIS TARS, TOBACCO ObLITERANS.) TOBACCO CHUNG, J lane analysis, A 10231, A 10468, e ffect of smoking, E 11679 (see also ARECA CHEWT:4G; SNORING; A 11199, A 11663, A 12314 experimentally induced, A 11770 SMOKING, CIGAR; SMOKING, PIPE.) carcinogenicity, A 10303, nicotine and, A 11770, E 10218, effect on fertility, F 12603 A 10839, A 11552, A 11905, E 12200, E 12447 effect on mucous membrane. A 12242, A 12646, C 10219, predisposing factors, E 11561 A 12579 /. 12642 C 10291 preventive medicine, E 12294 in mouth irphsm etiology, cocarcinogen(s) in, A 10333 smoking and, E 10847, E 11359, C 10713 effect on cell division, E 11561, E 12011, E 12149, in mouth neoplasm induction, A 11553, A 12646 E 12617, E 12650, C 12732 A 12579 effect on enyme activity, mouth nevi Aso and, A 12684, A 11866 TOBACCO C 1044.1, 1 11708 effect on lungs, D 10725 allergy, A 11060, D 11532, effect on tissues, C 12301 E 10368,E 12445,F 10548, TOBACCO INDJCTRY effect zn trachea, A 12646 P 10995,F 11740 advertising and,1 11625, J 11687, in lung neoplasm induction, analysis, A11061,A 11191, J 11988 A 12131 A 11194,A 112(5,4. 12028 agriculture and,J 11688 toxicity, A 11541, A 12646, arsenic content, E 11058 antismoking campaigns and, C 11998 1 11717, I 11718, J 10320, .1 10744 TOBACCO INAISTRY (Cont'd) TOBACCO LEAF COMPONENTS (Cont'd) TRYPTOPHAN METABOLISM (Cont'd) in Argentina, A 11178 phenols, A 10315, A 10789 in laboratory animals, A 10931 in Australia, J 1164k, J 12425 pigments, A 10937, A 11168 neoplasms and, A 11847 cigarette sales and, J 10655 polonium-210, A 10232 economics, A 11199, H 10503, scopoletin content, A 10311, TRYPTOPHAN METABOLITES, A 12813 I 11718, 1 17.720, I 11721, A 10312, A 11011 determination, A 10987 J 11636 sterols, A 10875, A 12632 fate in body, A 11033 in Germany, A 10832, A 10859 sugar content, A 10445, A 12639, indolea, A 12508, A 12593 history, I 11721 C 11151 in urine, A 10987, A 11031, in Lebanon, A 11176 tar content, A 10223 A 11032, A 11847, A 11999, in Philippines, A 11194 terpenoids, A 11184 A 12007, A 12508, A 12675, production, J 11636 tobacco mosaic virus in, A 11179, C 10473, C 10560, C 10605, ch programs, A 10832, A 11180, C 12473 C 10606, C 10852, C 11890, A 10859, A 11014, A 11161, tobacco variety and, A 10223, C 12008, C 12393, r 12435, I 11700, J 10405, J 10674, A 10232, A 10903 C 12647, C 12730, F 10458, .7 11886 F 10818, F 11311 safe cigarettes and, I 11701 TOBACCO MOSAIC VIRUS, A 11179 statistics, H 10351, J 10655 fate in body, C 12473 TUBERCULOSIS in Turkey, A 11181 fILJE. also RESPIRATORY TRACT in United States, A 1220), TOBACCO PYROLYSIS PRODUCTS DISEASES.) H 10351 analysis, A 10254, A 10833, bronchitis and, C 11874 in Yugoslm:la, A 11179 A 11015, A 11161, A 11208, diagnosis, D 11851 A 11228, A 11264, A 12340, in lung neoplasm etiology, TOBACCO LEAF COMPONEN-3 A 12456 C 11405 aliphatic amines, A 11186 aromati: hydrocarbons, A 11203 lung neoplasm and, C 10192 alkaloid content, A 10202, benzo(a)pyrene, A 12C46 smoking and, C 10192, D 12846, A 10445, A 10937, A 11012, carcinogenicity, A 10230, F 12214 A 12764 A 10831, A 10859, C 10291 amines, A 10411, A 11186 lactones, A 10254 amino acids, A 11175, A 11185 nicotine, A 11037 analysis, A 10310, A 10311, nitro/mines, A 10229 A 10312, A 10313, A 10314, phenols, A 11064 A 10445, A 10527, A 10787, quinones, A 10408 A 10875, A 10937, A 11161, tobacco variety and, A 11015 A 11175, A 11184, A 11187, ULCER, PEPTIC A 11191, A 11192, A 11193, TOBACCO SUBSTITUTES, A 11:014 (Eel also GASTROINTESTINAL A 11195, A 11667, A 12233, angina pectoris and, D 11798 DISEASES.) A 12699 cellulose, A 10340, A 11571 cite chewing and, F 11563 carboxylic acid esters, in cessation of smoking, A 11501 diagnosis, F 10275, F 10800, A 10310, A 10312, A 10313, F 12264 A 10314, A 10313, A 10875, TOBACCO VARIETIES, A 11178, A 11181 diet and, F 11870 A 21183, A 11187, A 11207, alkaloid content, A 12696 epidemiology, F 10117, F 11057, A 11208 amine acids in, A 11185 F 11098, F 11143, F 11312, carboxylic acids, A 10315, analysis, A 10875, A 10903, F 11513, F 11363, F 11981, A 10037, A 11165, A 12614 A 11182, A 11500 F 12163, F 12234, F 12298, carcinogenicity, A 10303, effect of fertilizers, A 1116f F 12391 A 12011, A 12639 nicotine content, A 11166, A 12097 etiology, F 10275, F 10654 determination, A 10233, norricotine content, A 12697, experimentally induced, F 10985, A 10903, A 11063, A 11183, A 11183 F 11098, F 11911, F 12032 A 12614 heredity as a factor, F 12179 effect of fertilizers, A 11163, TRACHEAL NEOPLASMS inhibition, F 10985 A 11165, A 11166, A 11167, (131. also RESPIRATORY TRACT lung diseases and, D 10695, A t1171 NEOPLASMS.) F 10317 eftect of moisture, A 11164, diagnosis, C 12810 morbidity, 8 10973 A 11165, A 11190 mortality, B 11516 mortality, D 10973 effect of processing methods, occupation as a factor, II 12262, A 10223, A 11172, A 11173, TRYPTOPHAN METABOLISM, A 11031, F 12163 A 11174, A 11175, A 11176, A 11032, A 11033, A 12593, pathogenesis, F 11911, F 12298 A 11177, A 11178, A 11185, F 10818, F 11311 personality as a factor, F 71218 A 11188, A 11189, A 11190, bladder neoplasm and, A 12815, predisposing factors, F 12358 A 11196 C 10298, C 10605, C 10606, preventive medicine, F 11870 nicotine, A 10223, A 10312, C 10852, C 12730 smoking and, C 10855, D 10448, A 11161, A 11163, A 11164, effect of nicotine, A 12508 D 10695, E 11093, E 11952, A 11165, A 11156, A 11167, effect of nicotine metabolites, F 10317, F 10582, F 10654, A 11169, A 11172, A 11173, F 10458 F 11046, F 11513, F 11563, A 11176, A 11193 effect of smoking, A 10384, F 11870, P 11179, F 22391, phenol content, A 11161, A 11168 A 12508, C 10605, C 10852 12415 145 ow.

ULCER, PEPTIC(Cont'd) WITHDRAWAL CLINICS(Cont'd) stress and, P 12218 methods,A10584, C 10663, therapy, 8 12753, C 12533, J 10282, J 10948, J 12217, 1' 10582, F 10682, F 11046, K 10507, K 10529, K 11552, F 1.098, F 11473, F 11981, K 10610,K11412, K 11495, F 12009,F12237, F 12264 K 11581,K11810, K 11910, K 12387, K 12389 URETHANE inNevYork,K12841 carcinogenicity,A11027, inNorm,K 12590 A12662,A12663 ch programs, G 10663, effect or cells,A11071, J 10842, K 11495, K 12590, A11476,A12662 K 12841 effect on enzyme activity, in Rhode Island, K 10283 A11476, in Aussie, K 10206 effect on hydroxylasa activity, in United Kingdom, J 10806, A11479 K 11507 effect on liver,A11476 vithdrmial symptoms,K10412, in liver neoplasm induction, K 10528 A11249 In lung neoplasm induction, A11249 metabolism,A11384 metabolism in liver, A 12,353 metabolites,A12653

UROGENITAL NEOPLASMS experimentally induced,A11018 morbidity, C 11482 smoking and, C 11950

UTERINE NEOPLASMS experimentally induced, A11335,A12761 mortality, 8 11324 smoking and, C 11950

WITHDRAWAL CLINICS (Da alsoCFSSATION OP POKING; REDUCTION OF SMOKING.) behavior therapy, J 10391, K 10401, X 10307, X 10382, K 10504, X 10519, K 105)3, K 10579, K 11412, K 11666 in California,A10584 drug therapy,A10584, J 10842, K 10206, K 10412, K 1041), K 10414, k 10325, K 10533, K 10613, K 10782, K 11.58, K 11367, K 11852 educational. therapy,A10584, K 10283, K 10528 evaluation, C 10663, C 10668, K 10525, K 10529, K 11507, K 11381, K 11910, K 12036, K 12841 follcv-up studies, K 10382, K 10782, K 12590, K 12641 group therapy, K 11666 hypr.osis in, K 11140, K 11666, 12229, K 12458

362 3442 IttU.S. GOVERNMENT PRINTING OFFICE,1970 - 311925 Public Health Service Publication No. 1124 Public Health Service Bibliography Series No. 45 June 1970

367