FISCAL From The Directors

Dear Colleagues, Advisory Boards for Fiscal 2011 This year marks a decade of strong commitment to technology transfer and economic development at the University of Illinois. It is fitting that this is also the year the Board of Trustees created Urbana the Office of the Vice President for Research and appointed Larry Schook as Interim Vice President, enabling the next step in the evolution of our offices. Bruce Vojak, Chair Van Anderson Advocacy and value creation have been the hallmarks of our Hans Blaschek accomplishments this past year as demonstrated in each Scott Carney initiative and achievement. Proof of concept funding programs Albert Feng on both campuses will help attract licensing partners for our Merle Giles high potential technologies. And joining with other top research Gregory Girolami universities to work with Osage University Partners will help us Gaines Hall realize the financial potential inherent in the preemptive rights Wen-Mei Hwu that are included in most licenses to University start-ups. Jozef Kokini Philip Krein The University of Illinois at , together with the NIH, Steven Leigh became the first in the world to share patents with Unitaid’s Paul Magelli Patent Pool, which makes new medicines more Romana Nowak affordable in developing countries. The Urbana campus Michael Philpott developed a unique label license for MIDA boronate technology Jennifer Quirk that enables Sigma-Aldrich and other suppliers to offer its Molly Tracy customers a royalty free license to the University’s intellectual David Weightman property, thus encouraging broad adoption of the technology in Huimin Zhao multiple industries. Chicago The efforts of the past ten years are yielding exciting rewards. Royalties have been strong for the past three years, largely William Beck due to the success of the HIV therapeutic Prezista. Our Offices Sue Fullman licensed a record number of start-ups this year, and in a four Dibyen Majumdar week period three start-ups from the Urbana campus raised more Bellur Prabhakar than $50 million in funding. Brenda Russell Larry Tobacman As always, none of our accomplishments would be possible Sol Shatz without the University’s stellar faculty and their willingness to Christine Wu engage in the technology transfer process. And we continue to be grateful for the support of University administration.

There are exciting initiatives underway that indicate the coming year will be one of continued growth. We look forward to partnering with you.

Nancy Sullivan Lesley Millar Director Director Office of Technology Office of Technology Management Management Chicago Urbana–Champaign

*cover image based on ILinnovations mirror.me profile 2 | FISCAL 2011 The Offices of Technology Management Fiscal 2011 Summary

Fiscal 2011 Totals Urbana Chicago TOTAL Disclosures 182 164 346 US Patent Applications Filed 166 183 349 US Patents Issued 68 23 91 Licenses & Options 55 44 99 Start-ups 12 8 20 Patent Reimbursement $1,446,568 $ 361,960 $1,808528 Royalties Earned $ 6,362,548 $ 12,718,808 $ 19,081,356

Fiscal 2011–Urbana Colleges and Units U.S. Patent Colleges and Units Disclosures Applications Filed U.S. Patents Issued Licenses & Options ACES 26 13 8 8 Applied Health Sciences 1 1 Beckman Institute 14 36 13 11 Education 3 1 Engineering 92 118 55 24 Fine and Applied Arts 6 Institute for Genomic Biology 15 10 2 2 Liberal Arts & Sciences 42 56 19 21 at Urbana 1 NCSA 4 2 2 1 State Surveys 5 1 1 1 Veterinary Medicine 5 2 1 2

Fiscal 2011–Chicago Colleges and Units U.S. Patent Colleges and Units Disclosures Applications Filed U.S. Patents Issued Licenses & Options Applied Health Sciences 3 1 1 5 Architecture & the Arts 1 Dentistry 4 8 1 1 Education 2 Engineering 27 32 6 7 Liberal Arts & Sciences 9 10 2 1 Medicine 91 98 14 27 Medicine - Peoria 2 1 2 Medicine - Rockford 2 2 Nursing 2 1 Pharmacy 19 39 3 4 Public Health 2

Note: As a result of the large amount of interdiciplinary research on campus, inventions are often associated with more than 1 college or unit. As a result, the numbers reported in the table may be counted multiple times, once for each associated college or unit. FISCAL 2011 | 3 University–Wide Updates & Activities

Dr. Lawrence B. Schook Named Interim Vice Stanford v Roche President for Research On June 6, 2011, the U.S. Supreme Court issued its decision in Stanford v. Roche, a case involving a dispute over the ownership In November 2010 the Board of Trustees established the office of several patents related to HIV-detection kits. The decision of the vice president for research by re-titling the Vice President analyzed the question of invention ownership under the federal for Technology and Economic Development and expanding that Bayh-Dole Act (“the Act”), and may have an impact on research portfolio to include important responsibilities for the University’s universities, such as ours, which commercialize federally funded vast $725 million-a-year, externally funded research enterprise. inventions. President Michael J. Hogan appointed Lawrence B. Schook to serve as Interim Vice President for Research. The Supreme Court limited its review to the issue of whether the Bayh-Dole Act automatically vested title in federally funded Dr. Schook will facilitate collaborative research opportunities, inventions to Stanford. It held that the Act does not automatically streamline related policies and procedures, and act as a coherent, vest title to inventions in the federal contractor. The Court ruled unified voice for U of I research. that the Act did not contain adequate language to explicitly vest title to federally-funded inventions to universities and other federal contractors. This non-explicit language could not displace the Rankings and Recognition presumption that an inventor owns his/ her inventions. It is noteworthy that the Court said that it’s holding did not undermine The University’s technology transfer and economic development the scheme of the Act, whereby federal contractors may elect to system was nicely acknowledged this past year. retain title in inventions and commercialize the inventions. This is because many universities either institute policies to obtain • The University of Illinois Research Park was selected as one assignments from employees, or require their employees to sign of “10 Startup Incubators to Watch” by Inc.com. contracts requiring assignment of inventions.

• A report by the Intellectual Property Owners Association (IPO) In light of the decision, the University of Illinois is reviewing its listing the top 300 organizations granted U.S. patents in 2010 own practices and assessing whether any changes will need to be included the University of Illinois as one of only 14 universities made to best practices going forward. among that group.

• In addition, TechWeek, a conference celebrating technology, Start–Up America: Illinois Partnership web and interactive communities named John Banta, CEO & Managing Director of IllinoisVENTURES, to their list of the 100 In May, entrepreneurs from across Illinois gathered to launch most innovative names in Chicago technology. “Startup Illinois,” a branch of the Startup America Partnership. Startup Illinois enables mentors, funders, major corporations, service providers and state government organizations to Record Number of Start-ups collaborate to help entrepreneurs start and scale new companies in the state. Startup Illinois doesn’t fund new businesses; rather The University of Illinois licensed intellectual property to 20 start-up it links them to established advisors and organizations. Startup companies in Fiscal 2011, a collective record in one fiscal year Illinois is focused on helping young companies with high growth and also a record for each campus individually, 12 in Urbana and potential. 8 in Chicago. In a time of slow economic growth for the state and the nation, the Offices of Technology Management mark this as Startup Illinois is leveraging the best practices and national a significant achievement and further evidence that the stellar network of the Startup America Partnership, and combining them research conducted by our University’s faculty really is an engine with our growing state network to give Illinois entrepreneurs access of job creation and economic development. to valuable resources. illinois.startupamericapartnership.org

4 | FISCAL 2011 The Offices of Technology Management

Mobile Apps Diamond v. Chakrabarty 30th Anniversary

This past year the University began supporting iOS and Android Ananda M. Chakrabarty, Ph.D., is a Distinguished University development on campus and is set up to deploy apps to the Apple Professor at the University of Illinois College of Medicine at App Store and Android Market. Chicago. Prior to joining the faculty at UIC, Dr. Chakrabarty worked at General Electric, where his research led to the development The iOS Developer Program License Agreement and the Android of a genetically-manipulated microorganism that later became Market Developer Distribution Agreements have been signed so the subject of a landmark decision from the Supreme Court of the Offices of Technology Management can help the University the United States. At issue was whether genetically modified community access iOS and Android developer tools. The Offices organisms could be patented since the law held that living things are also managing the submission of University-owned apps to were not patentable. In the 1980 decision the court ruled in favor of Apple’s App Store and to the Android Market. Dr. Chakrabarty stating that “the fact that micro-organisms are alive is without legal significance for purposes of the patent law.”

U of I partners with Osage University Partners In September the University of Illinois celebrated the 30th anniversary of the Diamond v. Chakrabarty decision with a series of special events on the Urbana campus, including a public lecture Osage University Partners has raised a $100 million venture fund and a symposium focusing on the legal and business aspects and partnered with a lineup of some of the country’s top research of the decision. In all, more than 200 people attended and universities, including the University of Illinois, the University of participated in the day’s events. Michigan, Caltech, Columbia, and UC Berkeley among others, as part of an endeavor to help universities realize the financial potential inherent in the preemptive rights that are included in most licenses to University start-up companies.

The relationship-driven partnership between the University of Illinois and Osage is as simple as building in a paragraph into new licenses, granting Osage the ability to invest in start-ups on behalf of the University if it sees a possibility for a positive investment. Tradeshows & Conferences

Last year, the staff from the Offices of Technology Management attended, as well as presented at, many conferences and tradeshows around the country and internationally.

Note: OTM Professionals presented at the events in bold 2010 IEEE Great Lakes Technology Symposium , Ann Arbor, MI Association of University Technology Managers Annual Meeting, Las Vegas, Nevada Association of University Technology Managers Regional Meeting, Louisville, KY Drug Delivery Partnerships, Miami, FL Licensing Executives Society Annual Meeting, Chicago, IL Licensing Executives Society IP100, New York, NY Licensing Executives Society Spring Meeting, New York, NY Livestock Biotech Summit, Sioux Falls SD Illinois Water Conference 2010, Champaign, IL International Fruit Trees Association, Pasco, WA Joint Corn & Soybean Conference, Chicago, IL Midwest Clean Energy Forum, Chicago, IL Midwest Energy Forum, Chicago, IL Microscopy Society Conference, Nashville, TN Midwest CleanTech, Chicago, IL mTechx, Omaha, Nebraska NanoBusiness Conference, Chicago, IL Near Term Opportunities for Biorefineries, Chicago, IL North Central Land Grant Group Meeting, Indianapolis, IN Ocean Tomo Patent Auction, New York, NY PacifiChem, Honolulu, Hawaii Photonics West, San Francisco, CA Power and Electronics, Fort Worth, TX Radiological Society of North America Annual Show, Chicago, IL BIO 2011, Washington, DC University of Minnesota Plant IP Seminar, Minneapolis, MN University Startups Conference, Washington, DC Utrecht University Summer Seminar, Utrecht, Holland FISCAL 2011 | 5 Chicago Updates & Activities

Inventor of the Year Award UIC and NIH first organizations to share patents in UNIRAID’s Medicines Patent Pool The University of Illinois at Chicago has re-instituted the Inventor of the Year Award to recognize and honor an outstanding faculty This past year the NIH and the University of Illinois, Chicago member that has engaged with the OTM in the technology were first in the world to share patents with the newly established transfer process. Awardees are outstanding UIC inventors whose Medicines Patent Pool. The patents are the basis of the HIV drug efforts and commitment to innovation are proudly represented in darunavir. According to The White House Office of Science and the development of an invention that demonstrates potential to Technology, “The Medicines Patent Pool is supported by UNITAID, significantly contribute to society. The recipients of the 2010 award an innovative global health financing mechanism that was co- are Dr. David Carley and Dr. Miodrag Radulovacki. founded by Brazil, Chile, France, Norway and the United Kingdom at the United Nations General Assembly in 2006. It is a voluntary Dr. Carley and Dr. Radulovacki have made contributions broadly mechanism through which pharmaceutical patent holders can aimed to elucidate the causes and consequences of choose to license their patents to the Pool. The Pool then makes disorders by developing numerous therapies to treat sleep-disorder the licenses available to qualified third parties, such as generic breathing. Their ground-breaking results have culminated in an drug manufacturers, which will pay appropriate royalties on the IllinoisVentures-supported startup company, Pier Pharmaceuticals, sale of the medicines for use in developing countries.” that focuses on the treatment of obstructive sleep apnea. Proof–of–Concept Funding Chicago Innovation Mentors To change the commercialization gap the Office of Technology Chicago Innovation Mentors (CIM) is a new multi-institution Management in partnership with the Office of the Vice President initiative that cultivates university technology commercialization for Research, the Office of the Vice Chancellor for Research, by matching experienced entrepreneurs, executives, and domain and the Schools of Medicine, Pharmacy and Engineering have experts with innovating faculty. committed funding for a Proof of Concept Initiative to support commercialization of new technologies emanating from the CIM will initially support biomedical opportunities from the laboratories at the University of Illinois at Chicago. The initiative, University of Chicago, Northwestern University, and the University which will kick-off in Q1 FY2012, will provide development grants, of Illinois at Chicago, in collaboration with the iBIO® Institute. typically between $25,000 - 75,000 to evaluate and develop commercial possibilities of University technologies by allowing At the inaugural CIM kick-off event in November 2010, more than development, testing, or prototype construction. Projects will be 25 prospective mentors with diverse backgrounds and significant selected on the basis of having the greatest potential to either records of accomplishment met at the Gleacher Center to learn secure a license from industry, lead to the formation of an investor- more about how their talents could assist mentees, and specifically, backed startup company or secure SBIR/STTR or other grant faculty members, who have an interest in commercializing funding. research from their lab. Adapted from the Massachusetts Institute of Technology’s Staff Changes successful venture mentoring service, and being launched in collaboration with MIT, CIM places an emphasis on creating a safe haven for mentees. The Office said goodbye to two Technology Managers this year, Colin James and Shayan Sartipi. Congratulations to Colin for A key feature of the program is team mentoring. Faculty mentees completing law school and joining a local law firm and Shayan on will be assigned four or five mentors. The team concept brings his acceptance into medical school. We are, of course, sad to see diversity and balance. them go, but we wish them the best in their new endeavors. Michael Carr has been hired as a Technology Manager responsible for managing a portfolio of technologies emanating mainly from the College of Nursing, the School of Public Health, the College of Applied Health Sciences and the College of Business Administration. He joined the OTM as a Technology Analyst before taking on the role of Lead Commercialization Analyst in January 2010. Formerly, Michael worked in the R&D laboratory at D.A. Stuart, a chemical company that specialized in industrial lubricants and coolants.

David Klick has been hired as a Technology Manager responsible for managing a portfolio of medical-related technologies. Prior to joining UIC’s Office of Technology Management, David was an associate in the Office of Technology Transfer and Economic Development at the Georgia Health Sciences University.

6 | FISCAL 2011 The Offices of Technology Management

Chicago Innovation Pipeline Start-Up Successes

The new Chicago Innovation Pipeline website, a multi- It was a busy and successful year for Thermal Conversion institution collaboration that includes UIC’s Office of Technology Technology (TCT) and Alan Feinerman (Associate Professor Management, pools the highlights of licensable technologies from of Electrical and Computer Engineering). In March 2011 TCT five leading Chicago area research institutions so that industry can won this year’s $30,000 business concept award in the Clean browse and “shop” for innovations through a single, interactive Energy Challenge, a contest that pits area companies against web-based point-of-entry. The Pipeline includes information on each other for the best clean energy business ideas. TCT was several biomedical product types including pharmaceutical agents, also recently named to the 2011 list of Top 10 Defense Energy diagnostics and biomarkers, medical devices and research and Technology Solutions. From over 220 global applicants spanning drug development tools. It also highlights innovation in other areas the energy spectrum, the organizations with the most promising such as materials science (nanotechnology, robotics), alternative military-related technologies were selected to present to a panel energy and educational curriculum. of officials including the U.S. Army, U.S. Navy, U.S. Air Force, U.S. Department of Agriculture and U.S. Army Corp of Engineer. The Each technology’s brief description is accompanied by a graphic Top 10 organizations will attend Asia Pacific Clean Energy Summit representing its stage of development, from concept to market. A in Honolulu on September 13 and present their technologies in a document accompanying each description offers a non-confidential quick pitch session to the Department of Defense partners, as well summary of the technology, in many cases including links to the as energy industry professionals, investors, utilities, and corporate inventor, scientific publications and patent documents. strategic groups. TCT was also awarded a National Science Foundation STTR grant to fund further development work on their Last year, a prototype website in this new format was used to next generation vacuum insulated panel technology. showcase innovations from several research institutions at a joint exhibit during the BIO International Convention in Chicago. That UIC start-up company ImmersiveTouch™, founded by Dr. Pat successful experience motivated the institutions to develop a Banerjee recently sold its SENSIMMER® haptic augmented VR website for the Chicago Innovation Pipeline on a permanent basis. surgical system to Medical Education & Research Institute (MERI) in Memphis. The system is technologically advanced simulator The permanent site currently offers more than 75 innovative that provides sense of touch along with three-dimensional monitors technologies. The website (www.chicagoinnovationpipeline.org) as soon as it arrived at the Medical Education & Research will be updated semiannually. The current participants are Argonne Institute. The technology was invented in 2005, and only a National Laboratory, Children’s Memorial Research Center, Loyola handful of teaching institutions have one of the simulators. The University, University of Chicago, and University of Illinois at Memphis center is a partner with manufacturer ImmersiveTouch Chicago. for improving the Sensimmer technology and broadening its applications. At MERI, doctors can determine how closely the Chicago Innovation Spotlight technology mimics working with human tissue. OrthoAccel Technologies, Inc. develops and manufactures The Offices of Technology Management at University of Illinois an acceleration device for orthodontics. The company offers at Chicago, Northwestern University and University of Chicago AcceleDent System that reduces treatment duration for wearing in partnership with Chicago’s Clinical and Translational Science braces by applying pulsing forces in combination with standard Award Institutions, hosted the first ever Chicago Innovation orthodontics to move teeth faster through accelerated bone Spotlight event which brought together the best in high-potential remodeling. Founded in 2007, OrthoAccel is now selling its biomedical research that is either in the late-stages of research or AcceleDent System in Europe and Australia. They have also is a recent spin-out company. recently sought FDA approval to begin selling the product in the United States. The event introduced high-potential biomedical investigators and inventors in the late stages of research to about 100 industry Pier Pharmaceuticals recently changed its named from Steady scientists, business development professionals, and biomedical Sleep RX and named a new CEO. Peter W. Letendre, Pharm.D., investors for possible collaboration. Inventors each had five was named as CEO & President and elected to the Board of minutes to pitch their emerging licensing opportunities and startup Directors. Dr. Letendre is an accomplished pharmaceutical industry companies to representatives from businesses like Johnson & executive and leader with track record in commercialization, Johnson, Baxter, and Abbott Laboratories. business strategy and management in both large and developing pharmaceutical and biopharmaceutical companies. The company, founded in 2007, is a venture-backed clinical stage biopharmaceutical company focused on the development and commercialization of products to treat sleep related breathing disorders, notably obstructive sleep apnea, with its lead compound in development, PP-001. Institutional investors include IllinoisVENTURES and Origin Ventures.

FISCAL 2011 | 7 Urbana Updates & Activities

Proof–of–Concept Funding Licensing Partnerships

Two proof–of–concept award programs launched on the Urbana In addition to licensing twelve start-up companies last year, the campus last year. The first was offered through the Office of Office also negotiated several licenses with established firms. the Vice President for Technology and Economic Development (now the Office of the Vice President for Research) and was Sigma-Aldrich, headquartered in St. Louis, MO, is a leading awarded to Dr. Martin Burke for work on a platform to make small life science and high technology company providing chemical molecules for pharmaceuticals, Dr. Jian Jun Cheng for work on and biochemical products and kits used in scientific research, a nanoconjugate drug delivery platform, and Dr. Paul Kenis for biotechnology, pharmaceutical development, and high work on a microfluidic system for synthesis of radiopharmaceutical technology manufacturing. Sigma-Aldrich plans to utilize imaging agents. an innovative technology developed by Dr. Martin Burke to produce surrogates for boronic acids previously not easily The second was offered through the Institute for Genomic Biology accessible. The availability of these surrogates is expected to in partnership with the Office of the Vice President for Research. greatly enhance the syntheses of many chemically important The recipients were Dr. Matthew Wheeler and his collaborators small molecules such as pharmaceuticals and natural products. for their work on customized implantable therapeutics for wound healing and Dr. Brendan Harley for his work on composite Gelest, Inc., headquartered in Morrisville, PA, is recognized biomaterials for tendon defects. worldwide as an innovator, manufacturer and supplier of commercial and research quantities of over 2,800 organosilicon Under each of these initiatives researchers are chosen to compounds, metal-organic compounds and silicones. Gelest receive funding and support that helps bring their high potential has licensed organosilicon compounds designed for cross- technologies closer to commercial readiness. Awards are coupling reactions. The compounds can be used in a broad used by faculty entrepreneurs to reach critical developmental range of carbon-carbon bond forming reactions. Developed milestones that will bridge the funding gap between research and by Dr. Scott Denmark, Organosilicon reagents are highly commercialization. useful in organic synthesis due to their shelf and air stability, their insensitivity to water, and their ability to withstand further Recipients are selected for funding on the basis of having functionalization. clear market potential, targeted milestones, and well-defined deliverables, all resulting in the greatest potential to secure Memsic Inc., headquartered in Andover, MA, is a leading a license to industry or establish an investor-backed start-up provider of MEMS sensor components, inertial systems and company. wireless sensor networks for diverse real world applications ranging from automotive, consumer, industrial and aerospace. Memsic has licensed University of Illinois technology to produce Entrepreneurs in Residence at the Research Park the next generation of wireless sensors for monitoring civil infrastructure. The sensors are based on technology developed by Drs. Bill Spencer and Gul Agha. The new wireless sensor The Research Park has created an Entrepreneur-in-Residence platform will have multiple capabilities allowing sensing of (EIR) program that hires experienced technology entrepreneurs to vibration, temperature, humidity, and light and be optimized for provide consulting to new startups and prospective entrepreneurs. energy efficiency, and reliability. The program hires peers that have faced similar challenges in commercializing early-stage technology and are able to provide advice on their own path to successfully attract investment, Staff Changes revenue, and industrial clients.

The Office said goodbye to two Technology Managers this year, The EIRs provide bi-weekly office hours for availability and Johnathan Ho and Mark Kaczor. Johnathan was with us for two agreements for one year to provide meaningful business years as a Technology Manager handling Life Sciences, and Mark development assistance, communication strategy, and investor was a Senior Technology Manager handling Engineering who was preparedness. The EIR program also has monthly training with the OTM for more than 10 years. We’re of course sad to see seminars to cover the fundamental issues most entrepreneurs them go, but we wish them the best with their future endeavors. face, such as: intellectual property basics, business development and sales, SBIR/STTR grant writing, and investor options and Jennifer Rice has been hired as an Associate Technology negotiations. Manager for Life Sciences and a search is currently underway for a

Technology Manager specializing in Engineering. The program included four part-time EIRs in FY11; they are Harlee Sorkin, Tim Hoerr, Dennis Beard, and Jed Taylor. Since establishing this format in August 2010 the EIRs have had 170 counseling engagements over 10 months, working with 65 entrepreneurs (and prospective entrepreneurs), including 26% biotech, 14% engineering/devices, 43% software/hardware, 7% materials, and 10% services/consulting firms.

8 | FISCAL 2011 The Offices of Technology Management

Start-Up Successes Research Relationships Leading to Commercialization Results Many of our start-ups logged important achievements in the past year. Here are just a few: In 2007 BP announced a $500 million initiative to further research in bioenergy production through the creation of the Three start-ups raised a combined $50 million in funding in a Energy Biosciences Institute. The University of Illinois at Urbana- 4 week period: Semprius Inc. raised $20 million, SolarBridge Champaign, the University of California at Berkeley, and the Technologies raised $19 million, and MC10 raised $12.5 Lawrence Berkeley National Laboratory are partners in the million. Even more impressive is the number of investors who institute, which for the U of I is housed at the Institute for participated in these rounds of funding – more than 20 including Genomic Biology. Siemens and ARCH Venture Partners. To date, 23 invention have been disclosed to the OTM, half in The ShareThis web tool is accessed by more than 400 million the areas of gene enzymes and gene regulation. BP is pursuing users across 850,000 websites. patents on 9 of these discoveries. Gary Eden and Sung-Jin Park’s microplasma lighting company, Last year the University of Illinois and the Singapore Agency Eden Park, has graduated from EnterpriseWorks to a pilot for Sciences, Technology and Research (A*STAR) partnered to production facility. They also won a Red Herring 100 North form the Advanced Digital Sciences Center. The Center, located America Award. in Singapore, focuses on innovations that transform people’s utilization of information technology. Twenty faculty members from Phil Krein and Patrick Chapman’s solar panel inverters can be Illinois are affiliated with the Center. Although the Center is newly installed on rooftops with a simple plug-&-power functionality. formed, 1 disclosure has been received already, with many more Their start- up, SolarBridge, has started production on micro- anticipated. inverters.

Reebok announced an R&D collaboration with MC10, a start-up Communications & Marketing co-founded by UIUC faculty member John Rogers, which makes stretchable electronics. This collaboration will allow Reebok Communications and marketing efforts were in full swing last year, to utilize MC10’s revolutionary conformal electronics platform with some notable activities including: to transform wearable electronics into a whole new class of comfort. • Attending more than 27 conferences and tradeshows (see map on page 5 for locations). John Rogers is also a founder of Semprius, which focuses on solar panels for large-scale electrical generation. Semprius and • Sending out 5 press releases (through July) via Businesswire Siemens announced a joint development agreement in 2010. that were viewed more than 15,000 times.

ANDalyze expanded sales to China and Australia. This start-up • Reaching out to campus by hosting seminars and talks produces products to test for heavy metal contaminants, based on tech transfer issues (9), hosting informal coffee breaks on Yi Lu’s catalytic DNA technology. for folks to get to know us (8), and participating in faculty meetings, classroom presentations, and other departmental Diagnostics Photonics won $10,000 as runner-up in the events (20). statewide “Innovate Illinois” competition. Stephen Boppart and Scott Carney founded Diagnostic Photonics to develop a tool • Establishing a social media presence on Twitter, LinkedIn, and that can be used during surgery to determine whether cells in the Facebook. Our Twitter account (@ILinnovations) has accrued margin of a breast cancer tumor resection are cancerous. more than 550 followers and led to offline interactions and relationships.

• Establishing a blog (“Inside OTM”) to keep the campus community updated on our activities and on significant milestones for our start-ups and licensees.

• Creating slidecasts and videos to showcase our technologies.

Follow us on Twitter @ILinnovations to stay up to the minute on entrepreneurism, innovation, and intellectual property. FISCAL 2011 | 9 Five Year History By Campus: Fiscal 2007 – Fiscal 2011

UIC Invention Disclosures U.S. Patents Filed

400 400 UIUC 363 367 346 347 349 318 333 309 309 120 300 183 300 326 184 117 130 164 202 146 165 166 200 200

243 100 201 203 182 100 183 166 180 144 145 143

‘07‘08 ‘09‘10 ‘11 ‘07‘08 ‘09‘10 ‘11

U.S. Patents Issued Patents Costs 100 93 91 $6 80 24 23 $5

60 54 57 $4 50 15 10 16 $3 40 69 68 $2 20 40 38 42 $1

‘07‘08 ‘09‘10 ‘11 ‘07‘08 ‘09‘10 ‘11

Note: Fiscal 2011 Patent Costs are calculated on August 17, 2011; numbers not final

Licenses & Options Number of Start-Ups

99 100 20 18 80 44 8 61 61 14 60 49 18 49 11 12 21 10 16 88 40 7 5 2 12 6 1 3 20 43 33 40 55 37 6 6 6 2 5

‘07‘08 ‘09‘10 ‘11 ‘07‘08 ‘09‘10 ‘11

10 | FISCAL 2011 The Offices of Technology Management Royalties & Royalty Distribution

Top Royalty Generating Technologies

Chicago Royalties Earned By Campus

Multidrug Resistant Retroviral Protease Inhibitors: protease $20 $19.08 inhibitor compound known as Prezista and used to treat HIV-AIDS. $15.87 $15.20 UIC $15 TICE BCG: for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder, and for the prophylaxis of Ta and/or T1 papillary tumors following transurethral resection. UIUC $10 $9.03 $8.71 TIMS Elementary Math Program: an elementary school mathematics program for children in grades K-12. $5

Urbana ‘07‘ 08 ‘09‘ 10 ‘11 Deuterium Passivation: used in semiconductor devices, the technology provides a solution to hot carrier effects, which are known to cause problems with device reliability.

Native Oxide: a semiconductor technology used in laser printers, fiber optic communications, microelectronic devices and more.

Ecteinascidins: a cancer fighting compund isolated from a sea squirt, resulting in the drug known as Yondelis, which is approved for use in Europe.

Royalties Earned By Campus: Urbana Chicago ROYALTIES EARNED $ 6,362,548 $ 12,718,808 non-University Share $ 81,154 $ 220,436 patent protection fund $ 33,079 $ 0 patent expenses reimbursement $ 1,446,568 $ 361,960 Net available for distribution $ 4,244,809 $ 12,126,872

Actual Distributions Inventors Share $ 1,159,896 $ 4,248,008 University Share Unit/College/Campus $ 1,259,000 $ 3,192,660 OTM Cost Recovery $ 1,245,308 $ 4,549,745

Note: As a result of the large amount of interdisciplinary research on campus, inventions are often associated with more than 1 college or unit. As a result, the numbers reported in the table may be counted multiple times, once for each associated college or unit.

FISCAL 2011 | 11 Urbana Start–Ups

Nuvixa, Inc.

Nuvixa makes video more useful in on-line communications. The company’s audio-visual Nutritional Data Services conference technology provides customers with presence through a virtual green-screen, where This nutrition analysis tool (NAT) is provided as a they can chat with friends in a virtual space public service by the Food Science and Human complete with interesting backgrounds. The Nutrition Department at the University of Illinois. The virtual space can be utilized as a presentation tool is intended to empower individuals to select a tool, by letting presenters be in the same space nutrient dense diet and was developed by Jim Painter as their PowerPoint or video presentation, which and Chris Hewes, formerly of the College of Agricul- allows for a more realistic, face-to-face experi- tural, Consumer and Environmental Sciences. ence. Co-founded by Drs. Sanjay Patel and http://www.myfoodrecord.com Minh Do of the College of Engineering, Nuvixa is located in the University of Illinois Research Park. http://nuvixa.com/ Xerion Advanced Battery Corp.

Xerion Advanced Battery Corp. is exploring a novel method of using nanotechnology to increase ion transport and energy extraction to produce a new electrode architecture called Farmgateblog.com StructurePore. The StructurePore technology has the potential to charge electric car batteries in Farmgateblog.com is a blog for Cornbelt farmers and minutes and cell phone batteries in seconds. The agribusinesses. The Farmgateblog is the place to go to company is exploring military, industrial, and find integrated information across a variety of consumer applications. Based on the research of disciplines, including crop and animal sciences, ag Dr. Paul Braun of the College of Engineering, economics, ag engineering and agricultural policy, Xerion Advanced Battery Corp is located in addressing these disciplines as they meet, intersect Westminster, Colorado. and often intertwine to shape the environment in which http://www.xerionmaterials.com the ag community lives and works. Stu Ellis, formerly with the University of Illinois Extension, serves as the blogger and editor. http://www.farmgateblog.com/ Catylix, Inc.

Cornboard Manufacturing, Inc. Catylix specializes in the development of novel catalysts and reagents for chemical synthesis. CornBoard™ is a green wood alternative that is One of the most efficient ways to improve the made from biomass residue called corn stover. pharmacokinetic properties of a bio-active CornBoard takes the abundant and underutilized compound is the introduction of fluorine or a cornstover biomass and turns it into a new fluorine-containing functional group. Incorporat- building material that is an economical and ing just a single fluorine atom or fluorine-e- environmentally responsible alternative to pressed containing functionality can dramatically improve wood products. The company has already the pharmacokinetic properties of a potential launched a line of longboards and outdoor drug. Catylix is focused initially on developing a furnishings and has plans to expand into the new method for the incorporation of trifluoro- construction industry. The CornBoard technology methyl groups into compounds. The first was developed by Drs. Scott White and Nancy products will include a proprietary reagent for Sottos of the College of Engineering and the effecting trifluoromethylation and specialized Beckman Institute for Advanced Science and CF3-containing building blocks. Services for the Technology. The company is headquartered in preparation of trifluoromethyl-substituted aryl McKinney, Texas. and heterocyclic compounds on a custom basis http://cornboardmanufacturinginc.com will also be available. Based on the research of Dr. John Hartwig formerly of the College of Liberal Arts and Sciences, the company is currently determining where they will locate. http://www.catylix.com/

12 | FISCAL 2011 The Offices of Technology Management

Dioxide Materials, Inc.

Dioxide Materials develops and licenses new technology for CO2 remediation. This includes technology to reduce the amount of Aqueous Solutions CO2 that is produced, and technology to create uses for any CO2 that is formed. The The Geochemists Workbench is a set of software company is focused on devices that reduce tools for solving water quality problems, including the carbon footprint of homes and those encountered in environmental protection and businesses and processes that convert waste remediation, the petroleum industry, and mine CO2 into useful fuels and chemicals. The wastewater planning. The software is in use in company aims to make homes and more than 1,000 companies, universities and businesses safer and more energy efficient research institutions and is essential for water and to reduce the carbon footprint of US engineers, aqueous chemists, geochemists and industry. Founded by Dr. Rich Masel, Dioxide anyone else working with water quality data. Materials is located in the University of Illinois Aqueous Solutions will continue the distribution of Research Park. the Geochemists Workbench; founded by Dr. Craig http://dioxidematerials.com/ Bethke of the College of Liberal Arts & Sciences, the company is located in the University of Illinois Research Park.

Innovosoy, Inc. Text IE

InnovoSoy is dedicated to developing powerful Text IE is currently working on products and easy-to-use data visualization applications. and solutions leveraging the founders’ Innovosoy provides users with practical and expertise in the areas of machine cost-effective solutions to understand complex learning; natural language processing; and dynamic datasets such as population and information extraction and text mining. income growth, and the production, consumption, Founded by Dr. Dan Roth of the College and income elasticities of key commodities. Dr. of Engineering, the company is located in Peter Goldsmith of the College of Agricultural, the university of Illinois Research Park. Consumer and Environmental Sciences is the founder of Innovosoy; the company is located in the University of Illinois Research Park. http://globalfoodin3d.com/

ImmuVen, Inc. Multicoreware, Inc. ImmuVen develops novel drugs that can be MulticoreWare is a Software and Systems used to treat infectious diseases and cancer. Integration solutions company providing The company harnesses a powerful, emerging heterogeneous multicore solutions for high life science technology, T cell receptors, which performance computing applications. The are a unique class of immune-targeting company is currently working on applications in the therapeutic and diagnostic agents. These defense and aerospace, bio-informatics, life agents have significant advantages over sciences, imaging, scientific computing and antibodies, which are already a $20 billion/year financial services industries. MulticoreWare market against cancer, autoimmune, and embraces heterogeneous computing and its infectious diseases. Founded by Dr. David solutions benefit customers who require a higher Kranz of the College of Liberal Arts & Sciences order of magnitude performance with power and and Dr. Patrick Schlievert of the University of space constraints. Based on the research of Dr. Minnesota, the company is located in the Wen-mei Hwu of the College of Engineering, University of Illinois Research Park. MulticoreWare has offices in Urbana, Illinois; St. http://immuven.net/ Louis Missouri; and Saratoga, California. http://www.multicorewareinc.com/

FISCAL 2011 | 13 Chicago Start–Ups

Tianhe

Tianhe is a stem cell biotechnology company commercializing the inventions emanating from the labs of Drs. Zhao, Mazzone and Holterman within the Departments of Medicine and Surgery at the University of Illinois at Chicago. With operations in both Illinois and overseas, the Company is pursuing the application of stem cells for the treatment of autoimmune diseases. iMortal Tianhe is initially pursuing the treatment of Type 1 diabetes through a clinical system which extracts the patient own stem cells and utilizes iMortal is a startup company based on jointly them to re-educate the patient’s faulty immune developed intellectual property from UIC and the cells to prevent future immune response to the Mayo Clinic. The company is developing fall patient’s own insulin producing cell. prevention technologies for the aging population from work done in the lab of Dr. Mark Grabiner, Professor of Kinesiology and Bioengineering. Dr. Grabiner and his colleagues have been studying how older adults fall in order to provide preventative training to quickly regain their balance before falling.

Avanti Biosciences, Inc.

Avanti Biosciences Inc., an early stage biotech company has secured an exclusive license to a technology developed from the College of Pharmacy. Cell Biologics

Cell Biologics offers genetically modified and normal mouse primary endothelial cells and other mouse cell types based on proprietary techniques developed at the University of Illinois Chicago. While genetically modified mice have proven to be a useful model for many human pathologies, culture of murine normal or genetically modified endothelial cells and other mouse primary cells are extremely SentiQuest beneficial to multidisciplinary, biomedically important, endothelial cell research in the areas of cell adhesion, angiogenesis, gene therapy and drug SentiQuest provides feature based sentiment targeting. Cell Biologics is dedicated to the rapid analysis tools that analyze social media traffic on development of significant basic and clinical the internet. The technology was developed and research on the endothelium by saving investigators licensed by Dr. Bing Liu, Professor of Computer time, money, and laboratory costs in the production Science. SentiQuest provides services to of consistent normal and genetically modified cells in partners, including a well-known opinion a timely and reproducible manner. research firm.

14 | FISCAL 2011 The Offices of Technology Management

Progenicyte Therapeutics

Related technologies that allow the harnessing of the power of human neural stem cells were licensed to Progenicyte Therapeutics. Jointly developed between UIC and the University of Central Florida, the technologies will be used to develop regenerative medicine products and stem cell-based research tools. Progenicyte Therapeutics combines the efforts of cell biologists, geneticists, and clinicians to create PAX advancements toward effective treatment for a variety of malignant and non-malignant diseases. PAX is a solutions-based diagnostics company focused on the development and commercialization of innovative products that improve the quality of life and care for patients with depression and other mood disorders. The company has licensed an intellectual property portfolio that represents more than 25 years of extensive research by UIC's Dr. Mark Rasenick, an internationally recognized pioneer in G protein signaling and the molecular aspects of depression and antidepressant efficacy. Currently PAX is in the process of developing a PicoLife two-step blood test that will be useful to quickly and reliably assess a response to antidepressant Founded by Dr. Farid Amirouche, Professor of therapy by analyzing the movement of the Gs alpha Mechanical and Industrial Engineering at UIC, protein found in human blood. PicoLife is developing micropump technology that can be incorporated into medical devices. The company licensed intellectual property from the University related to micropumps that deliver small and accurate volumes of solutions. The company has investment from, and is working closely with, a large multinational pharmaceutical company on development of this technology.

FISCAL 2011 | 15 U.S. Patents Issued – Urbana

Patent # Title Inventor(s) Department(s) Electrical & Computer Eng, Materials 7,748,343 Electrohydrodyamic Spraying System Kyekyoon (Kevin) Kim, Ravindra Singh Science & Engr

Physics 7,749,922 Nanowire Structures and Electrical Devices Alexey Bezryadin, Mikas Remeika

Beckman Institute, Electrical & Magnetomotive Optical Coherence Stephen Boppart, Vasilica Crecea, Xing Liang, 7,751,057 Computer Eng Tomography Amy Oldenburg

Apparatus and Methods for Testing Mechanical Science and Engineering Jong Han, Muhammed Taher Abu Saif, 7,752,916 Micro Scale Samples Under Tension and (MechSE) Michael Uchic Compression in SEM Near Ultraviolet-Wavelenght Photonic- Electrical & Computer Eng 7,756,365 Crystal Biosensor with Enhanced Surface to Ian Block, Brian Cunningham, Nikhil Ganesh Bulk Sensitivity Ratio Chemistry, National Center for Identification and Characterization of 7,765,068 Neil Kelleher, Gregory Taylor Supercomputing Applications L Protein Fragments

Enhancement of Immune Response to 7,767,653 Federico Zuckermann Pathobiology Vaccine by Interferon Alpha Method and System for Extraction of Oil 7,767,836 Munir Cheryan Food Science & Human Nutrition L From Corn Beckman Institute, Electrical Jack Chen, Nannan Chen, Jonathan Engel, 7,768,376 Conformal Mesh for Thermal Imaging & Computer Eng, Micro and Zhifang Fan, Chang Liu Nanotechnology Lab 7,768,455 Antenna for Controlling Radiation Direction Jennifer Bernhard, Jessica Ruyle Electrical & Computer Eng Bioengineering, Electrical & Fluorescence Detection Enhancement Ian Block, Brian Cunningham, Nikhil Ganesh, Computer Eng, Materials Science & 7,768,640 L Using Photonic Crystal Extraction Patrick Mathias Engr

Methods for Determining Genetic Matthew Gordon, Pui-Yan Kwok, Paul Selvin, 7,771,944 Institute for Genomic Biology, Physics O Haplotypes and DNA Mapping Ming Xiao Palladium-based Electrocatalysts and Fuel 7,785,728 Robert Larsen, Richard Masel, Yimin Zhu Chemical & Biomolecular Engr Cells Employing Such Electrocatalysts Compositions and Methods for Dehydration Champak Chatterjee, Moushumi Paul, Willem 7,785,825 and Cyclization of Peptides, Synthetic Chemistry van der Donk, Lili Xie Compounds, and Lantibiotics Beckman Institute, Electrical & Steven Adie, Julian Armstrong, Stephen Method and Apparatus for Measurement of Computer Eng, Institute for Genomic 7,787,129 Boppart, Matthew Leigh, David Sampson, L Optical Properties in Tissue Biology Adam Zysk

Directed Assembly of Three-Dimensional Materials Science & Engr 7,790,061 Gregory Gratson, Jennifer Lewis Structures with Micron-Scale Features Aerospace Engineering, Materials Science & Engr, Theoretical & 7,799,251 Microcapillary Networks Jennifer Lewis, Daniel Therriault, Scott White Applied Mech

Beckman Institute, Chemistry L 7,799,554 Lateral Flow Devices Juewen Liu, Yi Lu, Debapriya Mazumdar

Dahl-Young Khang, Heung Cho Ko, Keon Jae Beckman Institute, Chemistry, Printable Semiconductor Structures and Lee, Shawn Mack, Matthew Meitl, Etienne 7,799,699 Materials Science & Engr L Related Methods of Making and Assembling Menard, Ralph Nuzzo, John Rogers, Yugang Sun, Zhengtao Zhu Mark Band, Miri Cohen-Zinder, James Bovine Abcg2 Gene Missense Mutations Drackley, Seroussi Eyal, Denis Larkin, Harris Animal Sciences, Biotechnology 7,803,919 L And Uses Thereof Lewin, Juan Loor, Micha Ron, Moshe Shani, Center, Biotechnology Center Joel Weller Atomic Lasers with Exciplex Assisted David Carroll, James Eden, Jason Readle, Electrical & Computer Eng 7,804,877 Absorption Joseph Verdeyen, Clark Wagner

Note: Patents that are licensed are noted with an “L”, patents that are optioned are noted with an “O”

16 | FISCAL 2011 The Offices of Technology Management

Patent # Title Inventor(s) Department(s) Electrical & Computer Eng, Materials Mechanical Science and Engineering Fully Automated Control System for Type I 7,748,343 Electrohydrodyamic Spraying System Kyekyoon (Kevin) Kim, Ravindra Singh Science & Engr 7,806,854 Edward Damiano, Firas El-Khatib (MechSE) Diabetes

Physics Milton Feng, Nick Holonyak, Han Wui Then, Electrical & Computer Eng 7,749,922 Nanowire Structures and Electrical Devices Alexey Bezryadin, Mikas Remeika 7,813,396 Transistor Laser Devices and Methods Gabriel Walter Beckman Institute, Electrical & Ting-Fung Chan, Matthew Gordon, Pui-Yan Physics Magnetomotive Optical Coherence Stephen Boppart, Vasilica Crecea, Xing Liang, 7,829,278 Polynucleotide Barcoding 7,751,057 Computer Eng O Kwok, Paul Selvin, Ming Xiao Tomography Amy Oldenburg L 7,829,342 Selective Aliphatic C-H Oxidation Mark Chen, M. White Chemistry Apparatus and Methods for Testing Mechanical Science and Engineering Jong Han, Muhammed Taher Abu Saif, A Novel Gene Encoding Resistance to 7,752,916 Micro Scale Samples Under Tension and (MechSE) Crop Sciences Michael Uchic 7,842,856 Herbicides Inhibiting Protoporphyrinogen Aaron Hager, William Patzoldt, Patrick Tranel Compression in SEM L Oxidase from Amaranthus Tuberculatus Near Ultraviolet-Wavelenght Photonic- Electrical & Computer Eng Methods for Controlling Dopant 7,756,365 Crystal Biosensor with Enhanced Surface to Ian Block, Brian Cunningham, Nikhil Ganesh Richard Braatz, Rudiyanto Gunawan, Michael Chemical & Biomolecular Engr 7,846,822 Concentration and Activation in Bulk Sensitivity Ratio Yoo Lim Jung, Edmund Seebauer Semiconductor Structures Chemistry, National Center for Identification and Characterization of Use of Tryptophan, Indole and Anthranilate 7,765,068 Neil Kelleher, Gregory Taylor Supercomputing Applications Pierluigi Barone, Jack Widholm, Xing-Hai L Protein Fragments 7,847,152 Analogs as Plant Transformation Selection Crop Sciences Zhang Agents Enhancement of Immune Response to 7,767,653 Federico Zuckermann Pathobiology Signals Processors, Signal Processing Vaccine by Interferon Alpha Beckman Institute, Electrical & 7,847,719 Methods, and Digital Filter Configuration Minh Do, Ha Nguyen Computer Eng Method and System for Extraction of Oil Methods 7,767,836 Munir Cheryan Food Science & Human Nutrition L From Corn Passive and Active Photonic Crystal 7,854,505 Brian Cunningham, Dennis Dobbs Electrical & Computer Eng Beckman Institute, Electrical Structures and Devices Jack Chen, Nannan Chen, Jonathan Engel, 7,768,376 Conformal Mesh for Thermal Imaging & Computer Eng, Micro and Zhifang Fan, Chang Liu 7,862,992 Dynamic Fermentation Controller Ganti Murthy, Vijay Singh Agricultural & Biological Engr Nanotechnology Lab Biosensors with Porous Dielectric Surface Electrical & Computer Eng, Materials 7,768,455 Antenna for Controlling Radiation Direction Jennifer Bernhard, Jessica Ruyle Electrical & Computer Eng 7,869,032 for Fluorescence Enhancement and Brian Cunningham, Wei (MSEB) Zhang Science & Engr Bioengineering, Electrical & Methods of Manufacture Fluorescence Detection Enhancement Ian Block, Brian Cunningham, Nikhil Ganesh, Computer Eng, Materials Science & 7,768,640 Beckman Institute, Materials Science L Using Photonic Crystal Extraction Patrick Mathias Engr L 7,872,563 Variably Porous Structures Paul Braun, Xindi Yu & Engr

Methods for Determining Genetic Matthew Gordon, Pui-Yan Kwok, Paul Selvin, 7,771,944 Institute for Genomic Biology, Physics 7,875,654 System For Forming Janus Particles Steve Granick, Liang Hong, Shan Jiang Materials Science & Engr O Haplotypes and DNA Mapping Ming Xiao 7,880,026 MOF Synthesis Method Richard Masel, Zheng Ni Chemical & Biomolecular Engr Palladium-based Electrocatalysts and Fuel L 7,785,728 Robert Larsen, Richard Masel, Yimin Zhu Chemical & Biomolecular Engr Cells Employing Such Electrocatalysts Materials Research Lab, Materials Manipulator for Rotating and Translating a Todor Donchev, Eric Olson, Ivan Petrov, 7,884,326 Science & Engr Compositions and Methods for Dehydration L Sample Holder Andreas Schmid, Ray Twesten, Jianguo Wen Champak Chatterjee, Moushumi Paul, Willem 7,785,825 and Cyclization of Peptides, Synthetic Chemistry van der Donk, Lili Xie Compounds, and Lantibiotics Coordinated Science Lab, Electrical Richard Chan, Milton Feng, Nick Holonyak, 7,888,199 PNP Light Emitting Transistor and Method & Computer Eng Beckman Institute, Electrical & L Gabriel Walter Steven Adie, Julian Armstrong, Stephen Method and Apparatus for Measurement of Computer Eng, Institute for Genomic 7,787,129 Boppart, Matthew Leigh, David Sampson, L Optical Properties in Tissue Biology Method and Apparatus for Producing Adam Zysk 7,888,625 Milton Feng, Nick Holonyak, Han Wui Then Electrical & Computer Eng Linearized Optical Signals Directed Assembly of Three-Dimensional Materials Science & Engr 7,892,734 Aptamer-Based Colorimetric Sensor Juewen Liu, Yi Lu Beckman Institute, Chemistry 7,790,061 Gregory Gratson, Jennifer Lewis L Structures with Micron-Scale Features Arabinitol Dehydrogenases from Chemical & Biomolecular Engr 7,892,804 Ryan Sullivan, Huimin Zhao Aerospace Engineering, Materials L Neurospora Crassa Science & Engr, Theoretical & Quaternary Oxides and Catalysts 7,799,251 Microcapillary Networks Jennifer Lewis, Daniel Therriault, Scott White 7,901,660 Jian Ku Shang, Pinggui Wu, Rongcai Xie Materials Science & Engr Applied Mech Containing Quaternary Oxides 7,902,353 Nucleic Acid Enzyme Biosensors for Ions Jing Li, Yi Lu Chemistry Beckman Institute, Chemistry L L 7,799,554 Lateral Flow Devices Juewen Liu, Yi Lu, Debapriya Mazumdar Methods and Systems for Computer Based General Engineering, National Center 7,904,512 David Goldberg, Xavier Llora, Michael Welge L Collaboration for Supercomputing Applications Dahl-Young Khang, Heung Cho Ko, Keon Jae Beckman Institute, Chemistry, Printable Semiconductor Structures and Lee, Shawn Mack, Matthew Meitl, Etienne L 7,906,320 Fluorescence Based Biosensor Juewen Liu, Yi Lu Chemistry L 7,799,699 Materials Science & Engr Related Methods of Making and Assembling Menard, Ralph Nuzzo, John Rogers, Yugang Chemistry, Materials Research Lab Sun, Zhengtao Zhu 7,909,971 Microfluidic Electrochemical Reactors Svetlana Mitrovski, Ralph Nuzzo

Mark Band, Miri Cohen-Zinder, James Symmetric Cryptosystem Using Cascaded Bovine Abcg2 Gene Missense Mutations Drackley, Seroussi Eyal, Denis Larkin, Harris Animal Sciences, Biotechnology 7,912,212 Tansu Alpcan, Tamer Basar Electrical & Computer Eng 7,803,919 Chaotic Maps L And Uses Thereof Lewin, Juan Loor, Micha Ron, Moshe Shani, Center, Biotechnology Center Method and System for Treating a Joel Weller 7,919,438 Mark Greeley, Nandakishore Rajagopalan Waste Mgmt Research Center Metalworking Operation Atomic Lasers with Exciplex Assisted David Carroll, James Eden, Jason Readle, Electrical & Computer Eng 7,804,877 Absorption Joseph Verdeyen, Clark Wagner 7,922,939 Metal Nanoparticle Inks Bok Ahn, Eric Duoss, Jennifer Lewis Materials Science & Engr

FISCAL 2011 | 17 U.S. Patents Issued – Urbana

Soybean Gene for Resistance to Aphis 7,928,286 Glen Hartman, Curtis Hill Crop Sciences L Glycines Microcantilever Heater-Thermometer with Mechanical Science and Engineering 7,928,343 Integrated Temperature-Compensated Fabian Goericke, William King, Jungchul Lee (MechSE) Strain Sensor Release Strategies for Making Transferable Alfred Baca, Heung Cho Ko, Matthew Meitl, Beckman Institute, Chemistry, 7,932,123 Semiconductor Structures, Devices and Etienne Menard, Ralph Nuzzo, John Rogers, L Materials Science & Engr Device Components Jongseung Yoon Method for Exchanging Messages and Electrical & Computer Eng 7,934,095 Verifying the Authenticity of the Messages in Yih-Chun Hu, Kenneth Laberteaux an Ad Hoc Network 7,938,337 Variable Orifice Nozzle Lei Tian Agricultural & Biological Engr Jones Phase Microscopy of Transparent Beckman Institute, Electrical & 7,940,399 Gabriel Popescu, Zhuo Wang Samples Computer Eng Energy-Efficient Optoelectronic Smart Electrical & Computer Eng 7,940,457 Yoon Soo Han, Kanti Jain, Linus Jang Window Dahl-Young Khang, Keon Jae Lee, Matthew Pattern Transfer Printing by Kinetic Control Beckman Institute, Chemistry, 7,943,491 Meitl, Etienne Menard, Ralph Nuzzo, John L of Adhesion to an Elastomeric Stamp Materials Scien Rogers, Yugang Sun, Zhengtao Zhu Surface Preparation for Thin Film Growth by John Abelson, Gregory Girolami, Navneet Chemistry, Materials Science & Engr 7,943,527 Enhanced Nucleation Kumar, Angel Yanguas-Gil Surface Preparation for Thin Film Growth by John Abelson, Gregory Girolami, Navneet Chemistry, Materials Science & Engr 7,943,527 Enhanced Nucleation Kumar, Angel Yanguas-Gil Herbert Bachler, Robert Bilger DECEASED, Beckman Institute, Electrical see Trust B of Robert Bilger Trust, Albert Feng, & Computer Eng, Molecular & 7,945,064 Intrabody Communication with Ultrasound L Charissa Lansing, William O’Brien, Bruce Integrative , Speech & Wheeler Hearing Science Adaptive Acquisition and Reconstruction of Nitin Aggarwal, Saptarshi Bandyopadhyay, Electrical & Computer Eng 7,945,305 Dynamic MR Images Yoram Bresler Materials Research Lab, Materials 7,951,276 Cluster Generator Todor Donchev, Ivan Petrov Science & Engr

Light Emitting and Lasing Semiconductor Milton Feng, Nick Holonyak, Adam James, Electrical & Computer Eng 7,953,133 Devices and Methods Gabriel Walter Electrochemical Deposition Platform for Mechanical Science and Engineering 7,955,486 Min-Feng Yu O Nanostructure Fabrication (MechSE) Eric Duoss, Jennifer Lewis, Mariusz 7,956,102 Sol-Gel Inks Materials Science & Engr Twardowski Bioengineering, Electrical & Fluorescence Detection Enhancement Ian Block, Brian Cunningham, Nikhil Ganesh, Computer Eng, Materials Science & 7,961,315 Using Photonic Crystal Extraction Patrick Mathias Engr

Preparation of Ultra-Shallow Semiconductor Junctions Using Intermediate Temperature Chemical & Biomolecular Engr 7,968,440 Edmund Seebauer Ramp Rates and Solid Interfaces for Defect Engineering Photonic Crystal Sensors with Integrated Fluid Containment Structure, Sample Electrical & Computer Eng 7,968,836 Handling Devices Incorporating Same, and Charles Choi, Brian Cunningham uses Thereof for Biomolecular Interaction Analysis Beckman Institute, Coordinated Multiplex Near-Field Microscope with 7,969,650 Paul Carney, Daniel Marks Science Lab, Electrical & Computer Diffractive Elements Eng

Note: Patents that are licensed are noted with an “L”, patents that are optioned are noted with an “O”

18 | FISCAL 2011 The Offices of Technology Management U.S. Patents Issued – Chicago

Patent # Title Inventor(s) Department(s) Soybean Gene for Resistance to Aphis Multiphase Converter Apparatus and 7,928,286 Glen Hartman, Curtis Hill Crop Sciences 7,768,800 Rongjun Huang, Sudip Mazumder Electrical and Computer Engineering L Glycines Method Microcantilever Heater-Thermometer with Mammalian Selenoprotein Differentially Alan Diamond, Vadim Gladyshev, Dolph Mechanical Science and Engineering 7,776,607 Human Nutrition & Dietetics 7,928,343 Integrated Temperature-Compensated Fabian Goericke, William King, Jungchul Lee Expressed in Tumor Cells Hatfield, Kuan-Teh Jeang, John Wootton (MechSE) Strain Sensor Targeted Drug Delivery of Pain and Release Strategies for Making Transferable Alfred Baca, Heung Cho Ko, Matthew Meitl, 7,776,819 Addiction Therapies Using Opioid Receptor- Zaijie (Jim) Wang Biopharmaceutical Sciences Beckman Institute, Chemistry, 7,932,123 Semiconductor Structures, Devices and Etienne Menard, Ralph Nuzzo, John Rogers, Mediated Internalization L Materials Science & Engr Device Components Jongseung Yoon 7,794,958 Methods for Diagnosing Endometriosis Asgi Fazleabas Obstetrics and Gynecology Method for Exchanging Messages and Electrical & Computer Eng Compositions and Methods for Treating HIV Ananda Chakrabarty, Anita Chaudhari, Tapas 7,934,095 Verifying the Authenticity of the Messages in Yih-Chun Hu, Kenneth Laberteaux Microbiology and Immunology, Dept. L 7,795,410 Infection with Cupredoxin and Cytochrome Das Gupta, Arsenio Fialho, Chang Soo Hong, an Ad Hoc Network of, Surgical Oncology C Tohru Yamada 7,938,337 Variable Orifice Nozzle Lei Tian Agricultural & Biological Engr Robert Costa, Vladimir Kalinichenko, Michael Methods of Inhibiting Tumor Cell Jones Phase Microscopy of Transparent Beckman Institute, Electrical & O 7,799,896 Major, Pradip Raychaudhuri, I-Ching Wang, Biochemistry and Molecular Genetics 7,940,399 Gabriel Popescu, Zhuo Wang Proliferation Samples Computer Eng Xinhe Wang Energy-Efficient Optoelectronic Smart Electrical & Computer Eng Transport Agents for Crossing the Blood- Ananda Chakrabarty, Tapas Das Gupta, 7,940,457 Yoon Soo Han, Kanti Jain, Linus Jang Microbiology and Immunology, Dept. Window L 7,807,183 Brain Barrier and into Brain Cancer Cells, Arsenio Fialho, Chang Soo Hong, Tohru of, Surgical Oncology and Methods of Use Thereof Yamada Dahl-Young Khang, Keon Jae Lee, Matthew Pattern Transfer Printing by Kinetic Control Beckman Institute, Chemistry, 7,943,491 Meitl, Etienne Menard, Ralph Nuzzo, John Fuel-Cell Based Power Generating System L of Adhesion to an Elastomeric Stamp Materials Scien 7,808,129 Sudip Mazumder, Sanjaya Pradhan Electrical and Computer Engineering Rogers, Yugang Sun, Zhengtao Zhu Having Power Conditioning Apparatus Surface Preparation for Thin Film Growth by John Abelson, Gregory Girolami, Navneet Chemistry, Materials Science & Engr Prashant (Pat) Banerjee, Gregory Dawe, 7,943,527 Compact Haptic and Augmented Virtual Computer Science, Mechanical and Enhanced Nucleation Kumar, Angel Yanguas-Gil L 7,812,815 James Drummond, Lucian Florea, Cristian Reality System Industrial Engineering Luciano, Arnold Steinberg, Milos Zefran Surface Preparation for Thin Film Growth by John Abelson, Gregory Girolami, Navneet Chemistry, Materials Science & Engr 7,943,527 Enhanced Nucleation Kumar, Angel Yanguas-Gil Modulation of MLCK-L Expression and Uses 7,825,101 Asrar Malik, Dolly Mehta, Shahid Siddiqui , Pharmacology Thereof Herbert Bachler, Robert Bilger DECEASED, Beckman Institute, Electrical see Trust B of Robert Bilger Trust, Albert Feng, & Computer Eng, Molecular & CatalActive Recombinant Memapsin & Arun Ghosh, Lin Hong, Gerald Koelsch, Xinli 7,945,064 Intrabody Communication with Ultrasound L 7,829,669 Chemistry L Charissa Lansing, William O’Brien, Bruce Integrative Physiology, Speech & Methods of Use Thereof Lin, Jordan Tang Wheeler Hearing Science Method and System for Managing a 7,840,353 Aris Ouksel, Lin Xiao Information and Decision Sciences Adaptive Acquisition and Reconstruction of Nitin Aggarwal, Saptarshi Bandyopadhyay, Electrical & Computer Eng Network of Sensors 7,945,305 Dynamic MR Images Yoram Bresler Biochemistry & Molecular Biology, Use of Specifically Engineered Enzymes to Materials Research Lab, Materials 7,858,745 Manfred Konrad, Arnon Lavie, Farhad Ravandi Biochemistry and Molecular Genetics, Enhance the Efficacy of Prodrugs 7,951,276 Cluster Generator Todor Donchev, Ivan Petrov Science & Engr Leukemia 7,871,787 Method for Diagnosing Endometriosis Asgi Fazleabas Obstetrics and Gynecology Light Emitting and Lasing Semiconductor Milton Feng, Nick Holonyak, Adam James, Electrical & Computer Eng 7,953,133 Ananda Chakrabarty, Tapas Das Gupta, Devices and Methods Gabriel Walter Microbiology and Immunology, Dept. L 7,888,468 Cytotoxic Factors For Modulating Cell Death Yoshinori Hiraoka, Vasu Punj, Tohru Yamada, of, Surgical Oncology Electrochemical Deposition Platform for Mechanical Science and Engineering Olga Zaborina 7,955,486 Min-Feng Yu O Nanostructure Fabrication (MechSE) Multicistronic constructs with siRNA to O 7,893,035 Christopher Gondi, S. Sajani Lakka, Jasti Rao Biomedical & Therapeutic Sciences Eric Duoss, Jennifer Lewis, Mariusz inhibit tumors 7,956,102 Sol-Gel Inks Materials Science & Engr Twardowski Geoffrey Bilcer, Thippeswamy Devasamudram, 7,897,635 HIV Protease Inhibitors Chemistry Bioengineering, Electrical & Arun Ghosh Fluorescence Detection Enhancement Ian Block, Brian Cunningham, Nikhil Ganesh, Computer Eng, Materials Science & 7,961,315 Fiber Optic Spectroscopic Digital Imaging Mechanical and Industrial Using Photonic Crystal Extraction Patrick Mathias Engr 7,907,272 David Rue, Alexei Saveliev, Serguei Zelepouga Sensor for Flame Properties Monitoring Engineering IG20 Splice Variants Therapeutics for Microbiology and Immunology, Dept. Preparation of Ultra-Shallow Semiconductor 7,910,723 Nirupama Mulherkar, Bellur Prabhakar Cancer of Junctions Using Intermediate Temperature Chemical & Biomolecular Engr 7,968,440 Edmund Seebauer Joseph De Simone, Ronald Hoffman, Donald Ramp Rates and Solid Interfaces for Defect Methods For In Vitro Expansion of 7,927,785 Lavelle, Nadim Mahmud, Mohammed Milhem, Hematology/Oncology Engineering Hematopoietic Stem Cells Yogen Saunthararajah Photonic Crystal Sensors with Integrated Fluid Containment Structure, Sample Composition and Method for Providing Advanced Pharmaceutical Sciences, Electrical & Computer Eng 7,943,569 Richard Gemeinhart, Jovita Tauro 7,968,836 Handling Devices Incorporating Same, and Charles Choi, Brian Cunningham Localized Delivery of a Therapeutic Agent Biopharmaceutical Sciences uses Thereof for Biomolecular Interaction Fibrous protein fusions and use thereof in Anne George, Jia Huang, David Kaplan, Analysis 7,960,509 the formation of advanced organic/inorganic Oral Biology Rajesh Naik, Cheryl Wong Po Foo Beckman Institute, Coordinated composite materials Multiplex Near-Field Microscope with 7,969,650 Paul Carney, Daniel Marks Science Lab, Electrical & Computer Diffractive Elements O 7,968,159 Vacuum Insulation Panel Alan Feinerman Electrical and Computer Engineering Eng

FISCAL 2011 | 19 Contacts Office of Technology Management Office of Technology Management University of Illinois at Urbana-Champaign University of Illinois at Chicago Ceramics Building, Suite 319 1853 West Polk Street, Suite 446 105 S. Goodwin Avenue Chicago, IL 60612 Urbana, IL 61802 • 217.333.7862 p: 312.996.7018 • f: 312.996.1995 [email protected] [email protected] http://www.otm.illinois.edu http://www.otm.uic.edu Director Director Lesley Millar Nancy Sullivan 217.333.6807; [email protected] 312.996.7018; [email protected] Associate Director Assistant Director of Business Development Delphine Kranz Jeremy Hollis 217.333.6807; [email protected] 312.355.1601; [email protected]

Assistant Director, Marketing/ Associate Technology Manager Senior Technology Manager Michael Carr Steven Wille 312.996.5833; [email protected] 217.244.5956; [email protected] Senior Technology Manager Mark Krivchenia Senior Technology Managers 312.996.6626; [email protected] Lisa Dhar 217.333.3715; [email protected] Technology Manager David Klick David Washburn 312.996.7779; [email protected] 217.265.0778; [email protected] Technology Transfer Coordinator Technology Managers Nelson Grihalde Nathan Hoffmann 312.996.4129; [email protected] 217.244.4747; [email protected] Professional Staff Emily Wee IT Technical Associate Alex Esparza 217.333.7198; [email protected] Legal Coordinator Rachel Hodges-Spitsberg Associate Technology Manager Business & Policy Coordinator Patricia Pfister Jennifer Rice Business Administrative Associate Patrick Coogan 217.244.1275; [email protected] Project Specialist Claudia Gatch Manaila Patent Coordinator Jeff Norgle Visiting Technology Manager Legal support provided by Michael Hant Svetlana Vranic-Sowers through the Office of University Counsel 217.244.7243; [email protected] Interns–Chicago Professional Staff Graduate Screeners: Senior Manager of Information Systems Mike Bohlmann Carson Ingo, Mike Carr, Rayna Kearney, Sameer Malik, Senior Patent Coordinator Bill Colburn Nan Zhang, Adam Sussman, Greg Blas, Kathleen Broughton, Business Manager Todd Creason Scott Green, Amelia Zellander, Lindsay Simpson, Charlie Shaw Patent Coordinator Brad Edwards Undergrads: License and Agreement Coordinator Karen Higgins Neelima Kartha, Brian Henry, Nicole Denton, Rae Crawford, Patent Office Manager Tracy Hunter Nabia Ali Office Support Associate Heather Jones Law Students: Account Technician June Luna Ashley Pawlisz, Javier Galaniz, Lin Xiao, Dan Pierron, Walter Vito, Senior Marketing Coordinator Nicole Nair John Cravero, Ashraf Abbas, Jonathan Schelling Paralegal-Compliance Coordinator Jane Reid Entrepreneur-in-Residence: Aviv Shoher Administrative Aide Billie Scales Chief Clerk Liz Schleef Legal Office Manager Donna Wilm Legal support provided by Karen Etheridge through the Office of University Counsel Interns–Urbana Adil Anjem, John Barthe, Kyle Beckemeyer, Morgan Coates Kathryn Cowles, David Dremann, Michael Hodnett, Nicole Janovick, Jennifer Schmidt, Jon Zombeck, Aaron Birk, James Clemmons, Michael Dueker, Justin Essig, Robert Reis, Akash Roy, Martin Malone, Jonathan Pearce, Amelia Salter