March 21, 1989 Vol. X_U No. 6 U.S. Department of Health and Human Services

National Institutes of Health Recori I ndefatigable Investigator Protein Chemist Saroff Honored By Colleagues By Anne Barber Turning 75 years old is just another milestone in rhe life of Dr. Harry A. Saroff, scienrisc emeritus working in NIDDK's Labo­ ratory of Biochemical Pharmacology. To help celebrnte this occasion, friends and colleagues held a symposium in his honor, Mar. 8, on "The Physical Chemistry of Proteins: 75 Years of Research." "This symposium was held to honor Saroff for his long-term commitment co excellence in basic science," said Dr. Allen P. Minron, a senior investigator in the same laboratory. "Harry has made numerous contributions to our knowledge of che physical-chemical properties of proteins," he said. "Jn fact, somecimes his contributions were so original that they were not fully appreciaced unril years later." Speakers included Dr. John T. Edsall, emeritus professor at Harvard University, who taught Saroff when he attended Harvard in 1947 as a research fellow; Dr. Harold A. Scheraga, Cornell Universicy; Dr. Robert F. Dr. David j. Lip111a11 (c), a /rm11~ 111edical staff fellow at NIH, has been na1ned first directot· of the new Steiner, University of Maryland; and Dr. Irv­ National Center for Biotechnology Information at NLM. Here he h11ddles with Rep. Claude Pepper ( I) and ing M . Klocz, Universicy of Illinois. Dr. Jesse NLM direct()r Dr. Donald A.B. Lindberg at a reception held recently in the Capitol. See story on page 3. Roch, director of intramural research for (See SAROFF, Page 4 ) A Scientist's Resource Survey Finds Low Use ACES Takes Hand in Cardiac Research Of Dental Sealants By Carla Garnett Only 7 .6 percent of American school­ The marriage of engineering co medicine is here co support their research." children have dental sealants on c,heir teeth, nor a new or unique macchup. Indeed one sci­ Dr. Joseph Parrillo, chief of the Clinical according to survey results announced by the ence is probably as old, and as experienced in Center's critical care medicine department and National Inscicuce of Dental Research at the collaboration, as the other. Once again the septic shock researcher, knows about ACES. annual meeting of the American Association rwo have been matched quire successfully at Seven years ago, BEIB developed an effective for Deneal Research. NIH with the creation of an aucomated heart syscem co crack and measure the race ac which The survey of almost 40,000 schoolchildren cell tracker. individual heart cells beat when exposed co was conducted during the 1986-87 school When septic shock occurs in patients, it serum from septic shock pacienrs. year. Dentists trained by the institute per­ slows down the work of the heart. The inva­ "Bill Schuette actually came up with the formed oral examinations on children ages 5 to sion of the bloodstream by an infeccion, or idea years ago," said Parrillo, recalling former 17 at schools throughout the United Scates. septic shock, critically depresses heart func­ ACES chief William Schuecte's concribucion co The demists recorded a number of oral condi­ tion. These are known medical faces. What is the development of the heart cell tracker. tions, including sealanr usage and roorh decay. also essential co know in septic shock research, During septic shock, researchers draw blood The sample population was selected to repre­ but much harder to determine, is the extent of from the patient. A serum is extracted from sent the approximately 43 million school­ the depression. the blood, placed in petri dishes containing children in the counrry. Enter the Biomedical Engineering and cultured heart cells, and observed through a Deneal sealants are chin p lastic films Instrumentation Branch (BEIB), a component microscope. Using chis procedure, scienciscs painted on the chewing surfaces of molars and of DRS that is the frequent problem solver for can study the effect the serum has on beating premolars (the ceeth directly in fronr of medical mysteries needing engineering heart cells. molars). Sealants were developed through den­ assistance. "During shock, one or more molecules tal research in the 1950's and l960's, and first "We collaborate and consult on many proj­ called myocardial depressant substances (MDS) became available commercially in the early ects with the scientists in the Clinical are released in the blood," explained Parrillo. 1970's. Since then, researchers have continued Center," acknowledged Eli Walker, chief of "MOS is one of the mediacors or causes of sep­ to refine application merho

SEALANT New Computer Consulting Service (Continued from Page 1) The NIH Computer Center, which has materials. provided computer services co the NIH com­ "l chink it's safe to say we're surprised by munity for more than 20 years, now has staff the findings. We'd like to see a much higher members available for one-co-one and small use of dental sealants," said Dr. Prescon A. group consulting appointments. This provides Littleton, Jr., deputy director of the institute. for an open discussion about the role of com­ ''A quarter century of research has found chem puters in che office. ro be completely safe, highly effective and The new consulting appointments are a very economical in preventing tooth decay." great opportunity to discuss how to get started According to Littleton, the chewing surfaces using computers to automate essential appl ica­ of children's teeth are the most susceptible co cions. For example, common areas of interest decay aod the lease beneficed by fluorides. The are connecting small computers to the Com­ survey found chat two-thirds of all cavities puter Center's mainframes, linking Local Area now occur in chis vulnerable area of che tooth, Networks (LANs) wich the mainframes, and where the pits and fissures trap food particles using the Birner international electronic mail and bacteria, which eventually fuel the decay network. The role of the Computer Center's process. "By combining the use of sealants and consultants in these appointments is not to Dr. Michael R.ogen recently joined the staff of the fluorides, tooth decay could be virtually elimi­ make decisions or design systems, but rather Pharmacological ScienceJ Program of NIGMS. He nated," Licrleton added. co provide the advice and expertise chat will oversee grants involving bio-related chemistry. Sealants, which can be clear in color or enables computer users to make informed Rogers, who received a Ph.D. in medicinal chemis­ tinted, are painted onto molars much the same choices. try from the University of Mississippi, haJ had a way that nail polish is applied to fingernails. When requesting a consulting appointment, long ,mociation with NIH. An NIADDK staff Because sealants prevent decay by the physical computer users will be asked for some infor­ fellow from 1972 to 1975, he received NIH sup­ barrier they create rather than by a chemical mation about the scope and purpose of the port for chemistry research while teaching at Virginia C(ilnmonwealth University in the late reaction, the decay protection is determined computer application to be discussed. Jn chis 1970'r, and was an expe,·t com11/ta11t to DRG by the sealant's ability co adhere to the tooth. way, the Computer Center staff members from 1980 to 1983. In 1983, Rogers became the As long as the sealant remains incacc, decay whose expertise most closely relates to a spe­ executive Jecretary of the bioorganic and natural will not develop beneath it. Sealants last as cific area of interest can prepare for the products chemistry study section of DRG, a post he long as IO years. consultation. When necessary, the Computer held until coming to NIGMS. Not only do sealants protect healthy ceech, Center staff members will recommend other but research has shown chat they arrest decay groups or information resources that can more when placed on top of a cavity early in specifically address the technologies required development by sealing off the supply of for a given application. nucrieocs to the cavity. For more information about the NJH Com­ "This is a cocall y pain free, preventative The NIH Record puter Center's consulting appointments, call Published biweekly at Bethesda, Md., by che Editorial measure chat is extremely effective. Parents all 496-2339. As with all Computer Center con­ Operations Branch, Division of Public Information, for the over the country should consider the benefits sulting services, such as rhe Pal Unit's information of employees of the National Institutes of of sealants for their children," Littleton said. telephone consulting and the Training Unic's Health, Department of Health and Human Services, aod According to the American Deneal Associa­ classroom courses and tutorial consulting, circulated co nonemployees by subscription only through tion's most recent data ( 1985), the cost of there is no charge for this new service. 0 the Government Printing Office. The content is rcprinrable applying a sealant to one tooth is approx­ without permission. Pictures may be available on request. imately $10 to $15. Use of funds for printing this periodical has been approved In 1983, insurance coverage for chis proce­ by the director of the Office of Management and Budget dure was sparse and inconsistent. Since chat through Seprember 30, 1989. time, however, a growing number of insurance Capitol Hill Walking Tour NIH Record Office Staff Correspondents: companies have begun co reimburse for apply­ Bldg. 3 1, Room 2B-03 CC, Ellyn Pollack Join R&W on an enlightening tour of ing sealants, making it more affordable. 0 Phone 496-2 125 DCRT , Christine Pennella Washingron's oldest residential community. DRG, Sue Meadows Here lived our wealthiest residents; and in the Editor ORR, Michael Fluharty Richard McManus DRS, Jim Doherty alleys, our most impoverished slum dwellers. FIC, Elizabeth Gillette Scientists Judge Fair Pare of the joy of being on the hill comes Staff Writers NCI, Patricia A . Newman from the access of nearby amenities: the Cap­ Anne Barber NEI, Claudia Feldman Five scientists from NIH were among the itol, l ibrary of Congress, Supreme Court, the Carla Gamete NHLBI, Blair Gately judges of the fifth annual Science Fair at Holy Folger, and the oldest ongoing farmer's NIA, Ma.rgo Warren Edita.r ial Assistant NIAID, James Hadley Cross Elementary School recently. market. Marilyn Berman NIAMS, Barbara Weldon Drs. Anthony Caner, Barbara Detrick, Tour dace is Saturday, Apr. 8, from 10 to NIDDK, Eileen Corrigan Ralph Helmsen, John Hooks and Vijay Singh 11:30 a.m. We will meet at 9:55 a.m. on the NJCHD, Carol Florance Tht NIH R«wd cescrves rhc rishc NIDR, Mary Daum volunteered to serve on a 17-judge panel chat corner of 1st St. and East Capitol St. (in front m make correcrions. changes, or NlEHS, Hugh J. Lee evaluated the projects and questioned che stu­ of the Capitol Building grounds). Cost for the dcleiions in , ubmirtcd copy in NIGMS, Wanda Warddell dent scientists. Winners will enter their tour, led by Jeanne M. Fogle, a local histo­ conformity with rhe polici~ of the. NCNR Gerry Pollen projects in a competition at the Montgomery rian, is $6. 50. Sign up today ac the R&W paper ao

Lipman Heads New Biotechnology Information Center Health Benefits Available For Temporary Employees The Federal Employees Health Benefits Dr. David J. Lipman, a former research sci­ Amendments Act of 1988 permits certain entist in NIDDK's Mathematical Research temporary employees, who were previously Branch, has been named the first director of excluded from enrollment, co enroll in the che new National Center for Biotechnology Federal Employees Health Benefits (FEHB) Information at NLM. Program. To implement chis new provision, He was introduced at a reception at rhe which is effective Mar. I 4, a special open Capitol lase month sponsored by rhe Friends of enrollment period will be held from Mar. 14 the National Library of Medicine and accended to Apr. 14. by Rep. Claude Pepper of Florida, who helped Temporary employees who were previously draft lcgislarion creating the cenrer. excluded from enrollment and have completed "I regard this as one of che monumental l year of current continuous employment, achievements of the Congress and the coun­ excluding any breaks in service of 5 days or try,'' Pepper said. "And I chink it has Jess as of Mar. 14, may register to enroll dur­ immeasurable hope and incalculable conse­ ing the open enrollment period. Personnel quence for our future." offices will be notifying those employees who A new division within NLM, the center, Dr. Jay Moskowitz (I), NIH associate director for appear to be eligible to enroll. funded at $8 million in its first year, has four science policy and legislation and also acting direc­ Temporary employees who enroll in the basic responsibilities, largely in support of the tor of NIDCD, meets with Pepper at a reception in FEHB program will have the full premium NIH-led human genome mapping and the Capitol celebrating creation of the 11ew bio- withheld from their pay. If you think you sequencing initiative: 1ech11ology i12formatio11 renter. meet the eligibility requirements and are To create aucomated systems for knowledge interested in enrolling in che FEHB program, about genes, co discover advanced ways co you should obtain the 1989 Enrollment Infor­ handle the explosion of new knowledge about will prevent duplication of research and mation Guide and Plan Comparison Chart for genes, co enable workers in the field co use therefore bring more frequent and faster Temporary Employees, RI 70-8, and a Health the new systems developed and co coordinate breakthroughs." Benefits Registration Form, SF-2809, from worldwide efforts co garher biotechnology Center director Lipman came co NIH in your personnel office. D information. 1981 as a medical staff fellow and has estab­ "The investigation of the workings of che lished himself as a leader in the field of human hereditary system is certainly the most biocechnolog)' information. His most impor­ exciting scientific enterprise of the century," tant work has centered on the development of said Dr. Donald A.B. Lindberg, NLM direc­ programs for searching nucleic acid and pro­ tor. "And it's a proud thing for the National tein sequence databases. His methods are widely w;cd and led to the discovery chat oncogene produces are related co protein growth factors. "Not only will the center serve as a reposi­ tory for biotechnology information," he said, "but l am confidenr that the new knowledge­ handling systems we design will themselves make a significant contribution to furthering research in this crucial field. " Although new types of hardware will proba­ bly be developed, Lipman emphasized that "one of the real focuses in the center is brain­ NIH director Dr. James B. \'(lyngaa,-de,, (r) a11d ware. We are going to cry to bring to the Pepper /iJten lo re111ark.1 al a Capitol press con­ library experts in a variety of areas and achieve ference announcing Lipman's appoimment to head a critical mass of brainware chat we can focus the biotechnology information center. on problems and come up with solutions which don't necessarily mean more Dr . .foseph A. Frank. director of magnetic reso­ computers. nance research, diagnostic radiology d-epa1·t1nent, Library of Medicine co be the information Lipman sics on the advisory board of Gen­ Clinical Center, recently led a research team that repository for the results that will come from bank and has written and coauthored many won a certificate of merit for the scientific exhibit, that research. " influential articles on various aspects of Assessment of Normal and Abnormal Renal Added Pepper, "Research on the human molecular biology and biosequence informa­ Function with Gd- DTPA- Enhanced Dynamic gene is one of the mosc exciting frontiers in tion. He has a bachelor's degree in biology MR Imaging, presemed during the 74th Scientific medicine at this cime, buc rhe rapidly grow­ with honors from Brown University and Assembly and Annual Meeting of the Radiological ing body of information is scattered and earned a degree in medicine from che Scace Society of North America held in Chicago . Other unwieldy. This center will link existing University of New York at Buffalo. He did team members inc/ride D,-. Peter Choyke, Mary biotechnology databases and make informa­ his internship in internal medicine ac the Girton, Sman Inscoe andJeanett e Black, all of tion available for worldwide dissemination. Ir University of Arizona ac Tucson. D CC's diagnostic radiology department. page 4 ~Record March 21, 1989

SAROFF Saroffs contributions have involved more ming and canoeing. He even designed and (Continued from Page 1) than just research and reaching. He has also built his own house back in rhe l950's. "Ir served on many NIH committees and was a rook 7 years," he says. "Bue l still continue to NIDDK and Minton presented che inrroduc­ pioneer in applying computers co protein anal­ live in it today." cory remarks. yses and mathematical modeling. Asked once by a friend when he would Saroff came co work at NJDDK 40 years Saroff retired from rhe Public Healrh Serv­ retire, Saroff answered, ''I'll retire when J ago as a research chemise. His primary interest ice Commissioned Corps l l years ago as a die." His friend responded, "No Harry, when has remained protein chemistry since che scientist director. He became a scientist your work gees embarrassing, retire." L940's. emeritus and special expert for the Laboratory To this remark, Minton answers, "Harry's "I scayed here because l consider chis a good of Biochemistry Pharmacology, NIDDK and stamina, borh physical and mental, is chat of a place co work. I could have moved out at any­ continues in chac post. person many years younger. Fortunately for time," he says. us, Harry is likely to be around here in the Saroffs overall contribution in the field of lab for a long time to come." 0 protein chemistry has been to increase rhe understanding of the interaction of proteins and ocher molecules and to provide a more thorough analysis of the binding process. Contract Meeting Planned "I also explore some of che statistics involved in the sequence of amino acids in "Subcontracts: Government and Industry proteins. This is important in evaluating data Issues" is the subject of an intensive 1-day in the binding of receptors to cells and rhe training seminar to be held at the Bethesda processes which trigger and control certain Holiday Inn on Apr. 5. The course is offered chemical reactions of physiological impor­ by che National Contract Management Asso­ tance," Saroff said. ciation, a nonprofit organization of more than Minton, who came to work for Saroff as a 23,000 government and industry conrracrs postdoctoral fellow in 1970 when Saroff was professionals. To register, conract Krisree M. chief of rhe Laboracory of Biophysical Chemis­ Ryman, 496-6838. 0 try, says, "Harry is quite a unique and modest person. He is so demanding of himself and ochers with respect to the quality of work. Dr. Harry A. Sarolf "Nobody reviews a paper like Harry, and nobody is as critical of his own work as "I spend about the same amount of time Harry." working in the lab as I used ro. I srill work at Saroff was one of the first NIH scientists to home, but so does mosc everyone else," Saroff join rhe Foundation for Advanced Education says. in rhc Sciences (FAES) and caught there for He continues co write and publish on an more than 30 years. He also taught protein average of a paper a year. "Since l don't have chemistry as an adjunct professor at George­ administrative duties anymore, this is fun. town University during the 1960's. "I feel part of the philosophy as we get Molecular models of hemoglobin and the older should be that we go back and behave alpha helix hang from che ceiling in Saroffs more like a postdoctoral fellow-working, bur lab in Bldg. 8; he uses chem as visual aids in without the direct supervision of a boss," he his teaching. While no longer teaching at the continued. "We can pick up problems chat do FAES, he continues to g ive regular seminars nor necessarily have co pan nut as successful for the different NIDDK laboratories. work. We can work on speculative problems." On reaching ar FAES, Saroff says, "The Regarding his honorary symposium, Saroff Department of Agriculture used co send a cou­ says, "The way I look at it, these people have ple of scudeors co my course every year. One contributed more than I have. I've been a Two members of the Contracts and Procurement Management Branch, NJEHS, recently UJon y<--ar, 1 received a phone call from one of the rather modest contributor. Edsall was my role awards i11 their profeJsio11. Allan Benton, chief con­ Agriculture lab chiefs saying, 'Harry, you will model and the other speakers are my have co do something about your course. My colleagues." tracting officer, received a plaque from the North Carolina co11gmsional delegation recognizing the whole g roup spends the entire week doing Born in New York City, Saroff received his your problems and not rhe work rbey are sup­ B.S. , M.S. , and Ph.D. degrees from the instilute's commitment to small bminmes. Marcia Soward, wntraaing officer, received a DHHS posed to be doing."' Rensselaer Polytechnic lnscicute in Troy, N.Y. "Dr. Saroff is indefatigable in the pursuit of He attended Harvard University after his mili­ R«ognition Award for exemplary service in contrad operations. protein structure, both physical and mathe­ tary service; before joining NJDDK in 1949, matical, and in every ocher way," says Dr. he worked for the Naval Medical Research Joseph E. Rall, NlH deputy director for intra­ Institute. mural research and longtime friend and A member of many professional organiza­ coBeague. "He was also a teacher to anyone tions and the author or coauthor of about a who would listen, even from the early days, hundred scientific articles and papers, Saroff on how to use computers effectively in still finds rime for outside inreresrs such as research." woodworking, folk dancing, tennis, swim- P3ge 5 The Record March 21, 1989

Social Workers Go Extra Mile To Help Patients, Families Tom Byrd Retires After Long Service to Clinical Pathology March has been designated nationally as the which in rum offered the family friendship, month to recognize rhe social work profession. native cooking and warm clothing for the win­ L. Thomas Byrd retired from the Clinical In·NIH's Clinical Center, there are 25 clinical rer weather. This same social worker is now Center's clinical pathology dcparcmcnc on Feb. social workers who help patients and families working with the U .S. Department of Scace 24 after more than 32 years of government deal with their problems. and che Philippine ambassador co the United service, 30 of which were spent in the The social workers assist with a wide range Scares to obtain home care supplies and equip­ department. of problems- from admission through hospi­ ment for rhe patient when she returns home. Byrd scarred as a technolog1st in me aepan­ calizacion and the return co the community. Another example involves a young child menc's clinical chemistry service in 1958. He became a supervisor in 1961 and the chief They are also trained to help patients and from the Midwest who was recently admitted rheir families cope with illness and access a for tteacment at NIH. Though accompanied cechnologisc of the chemistry service in 1965. wide array of health care benefits. by his mother, he was extremely frightened In 1972 he was selected by Dr. James Mac­ Last year, social services were provided co and cried out repeated Iy for his father. Since Lowry, chief of the department, co fill a new approximately 75 percent of all inpatients the family was unable co afford che additional position designated as "assistant co the chief." admitted to the hospital for more than 2 days. plane fare, the social worker concacced a More rhan 500 group sessions were offered co resource from che family's home state and was che patients and their fami lies for orientation, able co obtain a ticker for the child's father. education and support services. The father's presence was very reassuring co A typical example of social work involves a the boy and helped contribute co his recovery. young girl and her mother from the rural These are but cwo examples of services Philippines. They were admitted co the Clini­ provided by clinical social workers during che cal Center last fall for an extended stay and past year. The social work department is avail­ iniciaJly found themselves overwhelmed. The able co boch patients and employees and may attending social worker made contacrs with be concaq_ed ac 496-238 l. D members of the local Filipino community

NIAID Funds Study of HIV Infection Among Heterosexuals

Heterosexual men and women who are nor ually rransmicred diseases, coinfecrion with intravenous (1. V.) drug users but who are ac HTIV-1 or other retroviruses, infecrivicy of• high risk for HIV infection will be the focus the source case, and use or non use of con­ Tom Byrd of a major new epidemiology study announced doms. In adclition, the investigators will study by the National lnsriruce of Allergy and Infec­ che natural history of HIV infection by follow­ For chc past 16 years he served in chis tious Diseases. NIAID has awarded three ing pariencs clinically while simulcaneously position. contracts for a collaborative, prospective study assessing their immune system functioning. Dr. Ronald Elin, current chief of the of che transmission and natural history of Neurologic, neuropsychologic and neuro­ department, complimented Byrd for his many human immunodeficiency virus (HIV) infec­ radiologic testing of some seroposicive study years of outstanding service co the department tion among some 2,000 heterosexuals. Study participants will be carried out co determine and the government. centers in Newark, N .J., and Brooklyn, how HIV infects the brain and che nervous "T om has been the key person to keep the N.Y., and a data coordinating center in Ann system. Also, the progress of HIV infection in department on crack during che past several Arbor, Mich., received che contracc awards. heterosexuals will be compared with similar years," he said. "Tom established excellent First-year funding for che 5-year concraccs data accrued from people who have acquired rapport with all members of the department, meals nearly $4 million. HIV infection through ocher rouces, for exam­ so employees willingly went co him for advice Dr. Anthony S. Fauci, director of NIAID, ple, intravenous drug users. In addition, the or co resolve problems. He was exceedingly emphasized the importance of chis study for study will assess educational intervention effective ar resolving problems for the designing more effective strategies co prevent scracegies.- Laurie K . Doepel 0 employees and the department. His retirement and creac HIV infection. Although only 4 per­ is a milestone in (our) history." cent of all adults diagnosed with AIDS since With retirement, Byrd plans co spend more reporting began acquired the disease through rime traveling, playing golf and tennis, and heterosexual concacc, chis mode of transmis­ Horseback Riding Trip doing volunteer work. D sion accounts for 30 percent of all AIDS cases R&W and the Marriott Ranches invire you in women. Heterosexual HIV transmission co share che beautiful scenery of the Blue usually occurs by sexual contact with an I. V. Ridge mountains on h0rseback. Located in ECS Presents Lecture drug user. Hume, Va. (Fauquier County), Marriott The study sires were chosen in part because The NIH Employee Counseling Services Ranches in a sprawling 5,000-acre facility. chey are located in i nncr-city areas populated will present a lecture on "Drug and Alcohol Join us on Saturday, May 13 for a 4-hour ride by large numbers of HIV-infected drug users, Addiction: When Someone You Know Needs and a picnic lunch of burgers, salads-the a potential reservoir of infecrivicy for Help," presented by Scott McMillan, on works! Cose for the day is $48 per person. For heterosexuals. Wednesday, Apr. 19, from noon co 1 p.m. in more information, call che R&W Accivicies Among the factors co be evaluated for their Wilson Hall, Bldg. l. Desk, 496-4600. in0uence on the transmission and course of D This is pare of the Guesr Lecture/Film Series HIV infection are the presence of ocher sex- presented by ECS. D page 6

March 21, 1989

TRACKER researchers who wanted co measure the force (Continued from Page 1) and rate of the heart's contractions used a microscope and a chart recorder. Each tiny The heart cell cracker allows researchers co measure the depressed hearr activity caused by unit, produced and recorded in tiny zigs and zags on graph paper, had to be measured by MOS. hand. "We'd always been able co see che depressed "The tracker aces as an addendum to the activity through the microscope," said Par­ microscope," explains Mudd. "Ir replaces hand rillo. "What we needed was a way to measurements, is faster, more precise and quancitate what we were seeing. The cell more accurate. tracker helps us understand che disease much Although the cell cracker began as an aid to septic shock research, it is now used in other NIH labs as well. Dr. Gopal Krishna of NHLBI's Clinical Pharmacology Laboratory and Dr. Asher Shainberg, a visiting scientist at NINOS, were searching individually for a more productive As a mult of increased interest in the cell tracker way co conduct their research on the force and system, Eli Walker, engineer and chief of ACES, rate of contraction in heart cells. 1>rga11ized a team of mgi11eers to investigate future "I was talking with some people in technology in the field. Building 13 about my work," explained Krishna. "They cold me about this cracker." "It was just happensrance that Krishna dis­ covered the tracker," admitted Tom Talbot, and capability chat many researchers are who specializes in biomechanics and computer­ unaware of." ized data acquisition in ACES. "That's how Since its pilot phase, the tracker has gone we get most of our projects. Mose people only through remarkable improvement during its know about what we do (at BEIB) by word of short life. Talbot's software is just one of the mouth. Many are not aware of all our additions that made a good thing better. The cell tracker iJ only one component in a system services. "After Eli realized the interest that tracking that works using a microscope, videocamera, chart "I'm not knocking word of mouth, cer­ was generating," said ACES staff fellow Dr. rec&rder and video display terminal with keyboard tainly," said ACES Chief Eli Walker. "But we Joe Schmitt, "he formed a team to investigate and disk drive to determine the motion of heart have to be more deliberate in making our future technology in the field." cells. services available to those investigators who The group formed by Walker includes have a need. Our staff has tremendous talent among ochers the talents of Mudd, Talbot and better." Dr. Courtney Mudd, an ACES biomedical engineer, explains how the system works: "During the growth of the cells, small four­ micron, latex beads are added to the culture. The beads become attached to the cells as they grow." In an experiment, the beads are used as tar­ gets for the cracker since they move with the beaci ng cell. "The cracker cakes the magnified video image of the heart cell from a TV camera attached to the microscope," continues Mudd. "The cracker adds a target window co the image and then sends the image co a video monitor for observation." T he operacor can chen position the window over a bead, switch the unit to track mode and the window will lock onto the bead mov­ ing with the cell. The signal generated co move the window is fed to the computer and is a measure of the cell's movement. "We can resolve down co submicron move­ ment," concludes Mudd, describing the Designers and users of the cell motion tracker gathe,· in Dr. Joseph Parrillo's laboratory where septic shock resolution possible with the cracker. "Tom research is cond11cted. Pictured are (from I): Dr. Courtney Mudd, applied clinical engineeri11g section (Talbot) designed the software to handle the (ACES); Dr. Steve Hollenberg and Marion T.aumnce, Critical Cm·e Medicine, CC; Dr. Asher Shainberg signals once they are in the computer." of NINDS' Neurobiology Laboratory, D,·. Joe Schmitt and Tom Talbot of ACES; and Drs. Gopa! Krishna Before the invention of rhe cell tracker, and Giovanni Santostas of NHLBI. l"'&e 7 Match 2 1, 1989

Schmitt, an expert in optical techniques, Scherbenske Receives Nephrology Award Their agenda is already chock full of ideas for the tracker's furure applications and Dr. M. James Scherbenske, director of rhe enhancements. scruccure and function of the kidney; its bio­ renal physiology/cell biology program of the "Right now we're looking for improved chemistry, metabolism, transport and fluid­ Division of Kidney, Urologic, and Hema­ methods co measure the strength of contrac­ eleccrolyce dynamics; and the effects of drugs, rologic Diseases, N IDDK, recently received tion of cells in culture," continued Schmitt. toxins and ocher environmental substances on the American Society of Nephrology·s Special the kidney. "One of our goals is co better define the rela­ Recognirion Award for his outstanding and Scherbenske earned his Ph.D. in physiology tionship of a cell's displacement to its force." dedicated service to the nephrology com­ in 1966 from the University of South Dakota. The cracker's usefulness is clear and its munity during the past 20 years. After 2 years as an NIH-sponsored postdoc­ future in research seems certain, "The heart cell cracker is just one of many Presenting the award at the society's recent toral fellow at the University of Kansas annual meeting in San Antonio, ASN presi­ Medical Center, he began his NIH career in examples of successful collaboration berween dent Dr. Tom Ferris said, "Over the past 20 1968 as a health scientist administrator in che intramural scientists and BElB," says Walker. years, Jim has been involved with all of us Special Programs Branch of the then National " We are looking forward co future collabora­ who do research in nephrology. Anyone who Heart Institute. tions that can be just as successful." has applied for a research grant appreciates His previous honors include the NIH Merit what an arduous and wrenching experience it Award in 1980 and 1987 and the National can be. Jim has been a friend to all of us, nor Kidney foundation Distinguished Service only when we were successful, but also when Award in 1986. Accepting the ASN award, we were not." Scherbenske said, "This has made everything Research grants supported by che renal worthwhile in working at NIH and with physiology/cell biology program focus on the investigators in the renal community." underlying mechanisms of kidney disease; rhe -BiU Hall 0

McClure Heads Reproductive Sciences Branch

Dr. Michael E. McClure has recencly been appointed chief, Reproductive Sciences Branch, Center for Population Research, N ICHD. He joined NICHD in 1979 as a health sci­ entist administrator in the Reproductive Sciences Branch and most recently headed the branch Reproductive Genetics and Immunol­ Befo,·e software designed by Tom Talbot, researchers ogy Program. Prior co coming co NIH, he determined cell motio11 by ha11d, measuring each served on the graduate faculties of the depart­ small square ()11 graph paper generated by this ment of developmental therapeutics of rhe machine. Now the same quantities are tracked and University of Texas M.D. Anderson Hospital displayed a111omatically 011 compllfer screen using and Tumor Institute and the department of Talbot's software. cell biology of the Baylor College of Medicine. His research activities have centered on inves­ tigating molecular mechanisms of generic regulation. Dr. Michael E. McClure McClure received his undergraduate degree Monticello Tour in zoology from Purdue University in 1963; endocrinology, genetics and immunology, and his M.S. in cell biology in 1966 from the Join R&W on Saturday, Apr. 15, for a his­ peri-implanracion embryonic development. University of Texas; and his Ph.D. in 1970 in torical tour of the Charlottesville, Va., area, He replaces Dr. William A. Sadler who is including: Thomas Jefferson's Monticello; biochemistry from the University of Texas now dean of the graduate school of arts and historic Michie Tavern, one of the oldest Graduate School of Biomedical Sciences at sciences at Howard University. 0 homesteads remaining in Virginia; Ashlawn­ Houston. He is a current member of the American Highland, home bf President James Monroe; R&W Club Information Day and Charloccesville's downtown historic Association for the Advancement of Science, district. American Chemical Society, American Society On Wednesday, Apr. 5, R&W will sponsor Cost for the day is $42 for adults, and $30 for Cell Biology, the Biochemical Society a Club Information Day. The event will be for children ages 6-I L (12 and up pay adult (London), the New York Academy of Sciences, held in the exhibit and balcony areas of Bldg. price), which includes transportation, all Society of Research Administrators, Interna­ 10 from 11:30 a.m. to 1:30 p.m. Volunteer admissions and lunch at Michie Tavern. Bus tional Society for the Immunology of representatives will be available to answer will leave NIH Bldg. 3 lC at 7 a.m. and will Reproduction and the American Society for questions in their areas of expertise. Some rernrn at approximately 7:30 p.m. Make your che Immunology of Reproduction. demonstrations will cake place and club litera­ rescrvarions today ar the R&W Activities As chief of NICHD's Reproductive Sciences ture will be available. Come learn about the Desk, 496-4600. Payment required upon res­ Branch, McClure will adminisrer a program of various club membership opportunities avail­ ervation. Bus trip will be nonsmoking. 0 research in reproductive medicine, biology, able through R&W. 0 page 8 The Record March 2 I, 1989

NIEHS Funds $5 Million Research Center Consensus Conference Explores Oral Complications of Cancer Therapies By Hugh James Lee

The health effects of synthetic environ­ research in five major areas. These areas NIDR will cosponsor an NIH Consensus mental chemicals and the relationship between include: studies of the metabolism of benzene Development Conference on the "Oral Com­ nutrition and cancer arc two of the areas that in the body, and the mechanisms by which it plications of Cancer Therapies: Diagnosis, will be researched under a new 5-year, $5 mil­ causes diseases such as leukemia and anemia; Prevention, and Treatment," Apr. 17-19. The lion grant creating an environmental health investigation of the effeets on liver function of conference will be held in Masur Audicorium, sciences center at the University of Medicine polycyclic hydrocarbons, chemicals emitted Bldg. 10. Ocher sponsors include NCI, NIH and Dentistry of New Jersey-Robert Wood from vehicle exhausts, combustion and indus­ Office of Medical Applications of Research, Johnson Medical School in Piscaraway, N.J. rrial processes; monitoring of contaminants in Clinical Center, and FDA. The center is the 11th environmental health blood and urine correlated with levels in food, The conference will bring together dentists, sciences center funded by NIEHS. Dr. Ber­ water and air; studies of the role of nutrition physicians, other health care professionals and nard Goldstein has been named center in inhibiting and promoting the development representatives of the public. Following 2 days director. of malignant tumors; and research on how of presentations and discussion, a consensus Dr. David P. Rall, NIEHS director, said of toxins affect nerve cell transmission. panel will weigh the scientific evidence and the new facility, "Center grants allow the Center grants provide funding for admin­ formulate a draft statement. integration of a number of research and pro­ istrative costs, capital equipment, general "While there is common agreement that gram projects. Each center defines certain services, core support and feasibility studies. there are many oral complications associated areas of research interest, and rhe establish­ Other NIEHS centers are at Mount Sinai Med­ with cancer therapies, there is a lack of con­ ment of a center allows unity of purpose and ical Center in New York City; New York sensus about the best means of limiting and central administration under a center University; Johns Hopkins; Harvard; MIT; treating these problems," says Dr. Philip C. director." University of Rochester; Vanderbilt; Oregon Fox, chief of the NIDR clinical studies unit The new center will allow coordination of State University; University of California at and chairman of the planning committee for the research efforts of 30 scientists doing Berkeley; and University of Cincinnati. 0 the conference. "We all know the problems are there. Now we have co make more rational judgments about treatment, even though there NIEHS Scientist's Mutation Process Patented are no commonly accepted protocols." Dr. Thomas A. Kunkel, a researcher at widespread application in both research and The 2½-day conference is open co the pub­ NJEHS, has developed a process that has been industry. lic. There is no charge for registration. NIH patented and will now be marketed commer­ The process is· 10 times more efficient than has certified this conference as meeting the cially through licensing by the Department of previous processes used for the same purpose. criteria for 14 hours in category l of the phy­ Commerce. This increase in efficiency results from using a sician's recognition award of the American The process Kunkel developed in the Labo­ template to produce mutation that is not bio­ Medical Association. ratory of Molecular Genetics enables the logically active upon transfection inco a wild­ To register for cbe conference, contact production of site-specific mutations. The pro­ type organism. The Department of Commerce Kathleen Edmunds, Prospect Associates, cedure, used in toxicology testing and to has negotiated a licensing agreement with Bio­ Suite 500, 1801 Rockville Pike, Rockville, enhance the benefits of medical therapies, has Rad Laboratories of Richmond, Calif. 0 MD 20852, 468-6555. □

New NINOS Council Members Four new members have been named to the National Advisory Neurological Disorders and Stroke Council of the NfNDS. Appointed to 4-ycar terms are: Dr. Franklin Owen Black, chief of the department of neuro­ otology, Good Samaritan Hospital and Medi­ cal Center, Portland, Ore.; Dr. Verne S. Caviness Jr., chief of the division of pediatric neurology, Massachusetts General Hospital; Faustina Solis, professor of community medi­ cine, University of California-San Diego; and Dr. Robert H. Wilkins, chief of the division of neurosurgery, Duke University Medical Eight employees of N IDDK re,:ently received the NIH Merit Award from Dr. Phillip G

DRR Animal Program Director Retires Nursing Center Issues Report

The National Center for Nursing Research Dr. William Gay, direccor of the ORR has issued a report of a conference on Nursing Animal Resources Program (ARP) since 1980, Resources and the Delivery of Patient Care. retired recently after more than 34 years of The conference, held in 1988, assessed the service co NIH. state of knowledge concerning nursing Gay, who received a D.V.M. from Cornell resomces as related to the quality of care University in 1950, came co NIH in 1954 received by patients. It also addressed the fol­ after 2 years at the Walter Reed Army Medi­ lowing research areas: assuring the delivery of cal Center where he worked in experimental quality patient care, developing strategies for allocating nursing resources, identifying fac­ surgery. Prior co that he practiced in New York City for 2 years. He held his initial posi­ tors influencing retention of nursing staff, and tion of chief of the DRS animal hospital determining the influence of organizational structure and management on nursing section until 1963 when he joined the Animal resources. Conferees identified research results Resources Branch of the Division of Research in these areas chat can be transferred into prac­ Facilities and Resources, DRR's predecessor. tice and discussed areas needing further In 1966, he moved to NIGMS as program studies. director for comparative medicine, a position Suggestions chat emerged from the con­ he held concurrently with program administra­ Dr. William Gay ference included development of the following tor for the radiology and physiology training initiatives: programs. The toughest part of retiring, says the • Further studies on patient care from In 1967, he became chief of the NIGMS Bethesda resident, is severing the_daily contact efficacy and patient outcome perspectives; Research Grants Branch and also was involved with his colleagues in the laboratory animal • Collaborative research models for assuring in developing a special research program on and health-sponsored medicine fields. Bue he qualiry care and improving communication trauma and injury. After a stint as acting asso­ hopes their pachs wi ll cross as he remains between nurses and other health care ciate director of NIGMS, he moved to NIAID active as a private consultant in those fields. personnel; in 1971 as associate director of extramural -Michael Fluharcy 0 • Quality of care indicators and standards, programs, a position he held until rerurning and ways co link patient outcomes to cost; co ORR in 1980. • A' comprehensive standardized data base Gay has served on the board of directors on clinical and administrative nursing infor­ and as national president of the American mation and a system to disseminate chis Association for Laboratory Animal Science, is Eye Council Gains Three information to ·those who can benefit from it; a diplomate of the American College of Labo­ • Studies. of occupational health risks and rarory Animal Medicine, and has been on Three new members have been appointed co their influence on the availability of nursing several committees for the lnstiruce of Labora­ 4-year terms on the National Advisory Eye resources. tory Animal Research of the National Council, the principal advisory body co the For copies of the report, call 496-0207, or Academy of Sciences. Gay also has served on National Eye Inscicuce. They arc Ors. John write Office of Information and Legislative many NIH committees, and was chairman of W. Chandler, of Madison, Wis., Melvin D. Affairs, NCNR, Bldg. 31, Rm. 5B03, Beth­ the 1972 Scaff Training Excramurnl Programs Shipp, and David L. Sparks, both of Bir­ esda, MD 20892. D committee; the 1976 study of commissions mingham, Ala. The council includes 12 and imeragency coordinating committee; and a public members and 5 ex-officio Nine-hole GoH Begins 1978 cask force studying extramural facilities. representatives. He says his most satisfying accomplish­ Chandler is chairman of the department of The NIH R&W 9-Hole Golf League is ment, however, has come in recent years in ophthalmology ac the University of Wisconsin offering registration for rhis season's play, overseeing the evolution and growth of ARP's in Madison and a widely recognized authority which begins the first week of May and ends involvement in AIDS research by developing on corneal immunology, particularly related co Labor Day. The league accommodates all lev­ animal models and animal resources in all ocular herpes infections and che immunologic els of golfers, offering both competitive and seven ORR-supported regional Primate defense mechanisms of the ocular surface. noncompetitive play. Play is once a week after Research Centers. Shipp is an authority on health policy work at the Falls Rd. Golf Course. From the initial planning meeting in March related co vision care, and is an associate pro­ For further information on competitive 1983, the ARP effort has not only supplied fessor ac the school of optometry of the play, call Anne Marie Bozak, 496-8178. For investigators with che much-needed animal University of Alabama in Birmingham. further information on noncompetitive play or model, but it has also improved the health of Sparks is an internationally recognized for registration forms, call Julia Freeman, several primate species through better under­ expert on the neurobiology of the visual sys­ 496-7495. Registration forms should be com­ standing of how to treat simian AIDS, a tem. As professor of physiology and biophysics pleted and returned by Apr. 7. Officers will naturally occurring and usually fatal disease of in the neuroscience program at the University also be available ac the R&W Club Informa­ macaque monkeys. of Alabama in Birmingham, he has been a key tion Day on Apr. 5, ll:30 a.m . to 1:30 p.m. Gay is also proud of ARP's animal improve­ investigator of the neural mechanisms that in the Bldg. 10 concourse. ment program, which has provided NIH underlie the control of eye movements. 0 TI1e league's preseason event will be the support for upgrading animal facilities in Betty Sanders Open, tentatively scheduled for order co keep chem in compliance with newly the afternoon of Apr. 11 at the Falls Rd. instituted federal guidelines. course. D page lO The Record March 21, 1989

B.B. Brodie Dies, Former NHLBI Lab Chief Three Named to NIDR Council Three new members were appointed Dr. Bernard Beryl "Steve" Brodie, a university career as an assistant professor of recently co the National Advisory Deneal pioneering pharmacologist, died Feb. 28 at his pharmacology. He lacer was an associate pro­ Research Council. The three, who will each home in Charloccesville, Va. He was a founder fessor of biochemistry at NYU. serve 4-year terms, are Dr. Paul Goldhaber of and former chief of the Laboracory of Chemical In 1950, Brodie founded and became chief Waban, Mass.; Dr. Racquel Z. LeGeros of Pharmacology ac che National Heare Institute. of the Laboratory of Chemical Pharmacology, New York City; and Mary K. Richter of Brodie's scientific career was the basis of a NHI. During his 20 years there he brought Trencon, Ill. recent, popular biography, Apprentice to Gmiw, pharmacology into a new era and trained a Goldhaber is dean of the Harvard by Robert Kanigel, an unprecedented look at great number of the leading pharmacologists School of Dental Medicine and a professor of the traditional master-apprentice relationship of today, including Julius Axelrod, winner of periodoncology. His research focuses on bone alive in modern science. le describes a dynasty the Nobel Prize in 1970. resorption and formation in periodontal dis­ of American researchers, of which Brodie was After his retirement from NH!, Brodie ease. He has received the Internacional head, who for more than 40 years have made served as professor of pharmacology at Penn­ Association for Deneal Research Award for prize-winning breakthroughs in biomedical sylvania Seate University College of Medicine Basic Research in Periodontal Disease, che science. in Hershey, as a research consulcanc and Alumni Research Award Medal for 1966 from Brodie is considered co be the founder of lecturer at George Washington University and Columbia University, and the New York Uni­ modern pharmacology and the scientist who as a senior consultant ac Hoffman-La Roche, versity Alumni Association Award. A past brought the field of neurochemical pharmacol­ Inc. president of the American Associatio_n for ogy into its own in the 1950's and 1960's. He Brodie was elected a member of the established the concepts of drug rnerabolism National Academy of Sciences in 1966 and and pharmacokinetics that have become funda­ was a member of numerous scientific societies, mental rules in rhe clinical use of drugs. He including the American Chemical Society, the also pioneered che concept chat blood drug American Heart Association and the Royal levels muse guide therapeutic dosages and he Society of Medicine in London. established the basis for the chemotherapy ln his lifetime, Brodie authored or co­ of malaria using these rules. Moreover, Brodie authored more than 3 50 scientific was the first pharmacologist co discover drugs manuscripts. that ace on brain neurotransmitters and He is survived by his wife Ann of che home their metabolism and he established the and two sisters, Rachel Brodie Morris of foundation for che biochemisrry of brain Glenhead, N.Y., May Brodie Spevak of Oak­ neurocransmission. dale, Mich., and a nephew, Dr. Stephen He was born in Liverpool, England, on Morris, of New York. Aug. 7, 1909. He received an undergraduate A memorial service will be held on Thurs­ The three new ffltmbers of the National Advisory degree from McGill University in Monrreal day, May 4, at 10:30 a.m. in Lipsett Dental Re1earch Comzcil are (from !) Dr. Paul and his Ph.D. in chemistry at New York Uni­ Audicorium, Bldg. 10. All are welcome co Goldhaber, Mary K. Richter and Dr. Racquel Z. versity in 193 5, where he also began his artend. LeGeros. Dentai Research and the Internacional Associa­ tion for Deneal Research, he is a member of the Jnstitute of Medicine, National Academy of Sciences. LeGeros is the director of research and a professor of dental materials and biochemistry in the college of dentistry at New York Uni­ versity. She has been associated with NIH as a grantee, serving as principal investigator on a variety of research projects. The author of many articles relating co biological and syn­ thetic calcium phosphates, she has served two appointments on che oral biology and m<:di­ cine study section at NIH. Richter is executive director of che National Foundation for Ectodermal Dysplasias. She has been involved for many years in programs co educate the public and professionals about chis genetic disorder. She is also a member of the patient advocacy committee for skin disease research and the board of di reccors of the Millie Fenton, pre1ident of the NIH R&W Theatre Group, prmnts a $3,000 check to Stan Kissel, chief of National Organization for Rare Disorders. In the Clinical Cemer's social work department , which 111a11age; the Patiem Eme1-ge11cy Fund. The money was June 1988, she served as a panelist for the raised from the group's fall 1nusical, The Forgotten Fifties. Looking 011 are group members (from I) John NIH Consensus Development Conference on Spouge, Ma,y Graham, Charlotte Brown and David Rainey. Deneal Implants. 0 page 11 ~Record March 2 I, 1989

fi/tf§ TRAINING TIPS '§f!!J Jeanne Winnick Retires; Ends 37-Year Federal Career The NIH Training Center of the Division of Personnel Management offers rhe following: Jeanne R. Winnick, a public information specialist in NIAID's Office of Communica­ Courses and Programs Dater tions, has retired after 3 7 years of federal service. Management and Supervisory 496-6371 Working W ith Personal Difkrcnccs MBTI in She began her career in the institute in Work Group; 4119 1972 as a secrerary in the Office of Communi­ Necworking: Sil

NIDR Sponsors Research Training for Minorities

Minorities interested in research careers have Scientists already have discovered chat many a unique opportunity at the National Institute different types of bacteria employ specific cell of Deneal Research. Each year, NIDR selects a surface proteins called adhesins co attach co minority postdoccoral candidate (dentist) for a oral tissues. The adhesins bind co receptors on 1-co 3-year research training assignment at the reeth and soft tissues, thus beginning the institute. This opportunity is made available colonization and the initiation of disease. through the National Research Service Award Cherry and her colleagues hope chat a better (NRSA) program. understanding of che molecular mechanisms of "I prefer a career in dental research," says microbial adherence will lead co novel Dr. Gail Cherry, a minority participant in the approaches for preventing this initial phase of NRSA program. ""If we can better understand rhe oral disease process. the causes of various oral diseases, perhaps we Minorities interested in this special research can acquire the knowledge co prevent chem. I uaining opportunity must have a D.D.S. with chink research is extremely important and l co 5 years poscdoccoral experience. Addi­ challenging for that reason," she said. tionally, candidates must be U.S. citizens or Cherry received her B.S. in microbiology have been lawfully admitted co che U.S. for from Howard University in 1982 and her permanent residence. A minority is defined as D.D.S. from Howard's College of Dentistry in Dr. Gail Che,ry, a black, Hispanic, Native American, or Asian/ 1987. She learned about the NRSA rese-arch Pacific islander. opporcunicy from faculty, colleagues and bul­ Candidates muse submit a letter of recom­ letins while completing her residency in biomedical research disciplines." mendation from the dean of their dental general dentistry at Sr. Elizaberhs Hospital. Cherry works in the pathogenic mechanisms school, a curriculum vitae and a completed Cherry scares, "The curriculum in dental section of the Laboratory of Microbial Ecology. NRSA application. A description of the schools does not offer fellowships and/or Together with Drs. John Cisar and Ann L. research the applicant is interested in muse research training programs. It is especially Sandberg, she is focusing her attention on che also be included. Applications must be important for minorities to pursue chis excep­ adherence properties of bacteria that colonize received by Apr. 3. tional opportunity for training in an area of teeth, form dental plaque and contribute co For further information contact Lorrayne dental research because they are underrepre­ the initiation of gingivitis and periodontal Jackson, NIDR EEO manager, Bldg. 3 1, Rm. sented in the laboratory and clinical disease. B2B39, 496-3046. 0

Poussaint To Lecture at NIH Overview of Peer Review In observance of National Women's Hiscory A STEP Forum entitled, ""Overview of NIH Month, Renee Poussaint, anchor of WJLA­ Experiments and Studies on Peer Review," TV's evening news programs, will describe will be held Apr. 5, from 1:30 co 4 p.m. in how she attained this position. The lecture, Wilson Hall, Bldg. 1. sponsored by the NIH Women's Advisory The NIH peer review system is an integral Committee and the Federal \'(/omen's Pro­ part of support for biomedical research. NIH gram, will be held on Thursday, Mar. 30, has recently initiated studies and reseed experi­ from l l:30 a.m. co 12:30 p.m. in Masur mental approaches co appraise the peer review Au