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Book-Of-Apstracts-6Th-Congress-SGS.Pdf BOOK OF ABSTRACTS BOOK OF ABSTRACTS Abstracts of the 6th CONGRESS OF THE SERBIAN GENETIC SOCIETY Publisher Serbian Genetic Society, Belgrade, Serbia www.dgsgenetika.org.rs Editors Branka Vasiljević Aleksandra Patenković Nađa Nikolić Printing Serbian Genetic Society, Belgrade, Serbia Number of copies printed 300 Design October Ivan Strahinić Ana Kričko 2019 2019 ISBN 978-86-87109-15-5 VRNJAČKA BANJA SERBIA SCIENTIFIC COMMITTEE WELCOME TO VI CONGRESS OF THE SERBIAN GENETIC SOCIETY! Branka Vasiljevic (Serbia) - CHAIR Dear colleagues, Jelena Knežević Vukcevic (Serbia) Ninoslav Djelic (Serbia) Welcome to the 6th Congress of the Serbian Genetic Society. The Serbian Mihajla Djan (Serbia) Ksenija Taski-Ajdukovic (Serbia) Genetic Society (SGS) has been founded in 1968 and the first Congress Marija Savic Veselinovic (Serbia) Jelica Gvozdanovic-Varga (Serbia) organized by the SGS was held in 1994 in Vrnjacka Banja. Since then, the Andjelkovic Violeta (Serbia) Olivera Miljanovic (Montenegro) Congress of Serbian Genetic Society is held every five years. Over the past Marina Stamenkovic-Radak (Serbia) Vladan Popovic (Serbia) years, the Congress has grown from a national to an international meeting. Ander Matheu (Spain) Dejan Sokolovic (Serbia) Dragana Miladinovic (Serbia) Milomirka Madic (Serbia) The experience of the past meetings motivated our efforts to continue with Branka Vukovic Gacic (Serbia) George Patrinos (Greece) this series with a clear tendency to strengthen the scientific connections Snezana Mladenovic Drinic (Serbia) Milena Stevanovic (Serbia) among researchers from different European countries. Ana Cvejic (United Kingdom) Sonja Pavlovic (Serbia) Milorad Kojic (Serbia) Dragica Radojkovic (Serbia) The Congress will focus on the most recent advances in genetics and on Slavisa Stankovic (Serbia) Jelena Milasin (Serbia) wide range of topics organized in 9 sessions and two workshops. Many of Jelena Blagojevic (Serbia) Vittorio Venturi (Italy) the presentations will be in lecture-like settings, but we hope that there will Domagoj Simic (Croatia) Ivana Kavecan (Serbia) also be ample opportunities for informal interaction outside the scheduled Milan Mataruga (Bosnia and Herzegovina) Ivana Novakovic (Serbia) sessions. Michael Lisby (Denmark) Bojana Zegura (Slovenia) Jelena Srdic (Serbia) Metka Filipič (Slovenia) The successful organization of the Congress has required the talents, Ana Marjanovic Jeromela (Serbia) Jose Perez-Martin (Spain) dedication and time of many members of the Scientific and Organizing Ivana Strahinic (Serbia) Thomas Flatt (Switzerland) committees and strong support from our sponsors. I hope that you will Dusica Vujaklija (Croatia) Vladimir Trifonov (Russia) find the Congress both pleasant and valuable, and also enjoy the cultural and natural beauty of Vrnjacka Banja. Yours sincerely, ORGANIZING COMMITTEE Milena Jankovic – CHAIR Mirjana Novkovic Radovan Milicevic Sanja Cirkovic Nadja Nikolic Branka Vasiljevic Ivana Aleksic Ivica Dimkic President of the Serbian Genetic Society CONGRESS OF THE SERBIAN GENETIC SOCIETY CONGRESS Vesna Kandic Tanja Beric Milan Stevanovic Stoimir Kolarevic Dusica Jovicic Biljana Nikolic Petar Canak Jelena Aleksic Aleksandra Patenkovic Milica Keckarevic-Markovic Milomir Stefanovic 4 5 TABLE OF CONTENTS Human omics variation Medical genetics Genetic toxicology: from cell to ecosystem Adaptation and ecological genetics Genetic diversity, phylogeny and conservation Breeding for changing environments Microbial genetics Bioinformatics and big data analysis Miscellaneous topics CONGRESS OF THE SERBIAN GENETIC SOCIETY CONGRESS Personalized medicine: promise and reality The truth is in wine and DNA – applications of molecular methods in viticulture 6 7 Plenary lectures VI CONGRESS OF THE SERBIAN GENETIC SOCIETY PL – 01 Plenary lecture PL – 02 Plenary lecture UNTANGLING BIOLOGICAL COMPLEXITY: GENETIC COUNSELLING IN THE ERA OF GENOMICS MEDICINE FROM OMICS DATA TO NEW BIOMEDICAL KNOWLEDGE Christine Patch Natasa Przulj Genomics England, Lonodon, United Kingdom Catalan Institution for Research and Advanced Studies, Barcelona Supercomputing Center, Barcelona, Spain [email protected] [email protected] Medical Genetics is at an exciting transition point partly due to technological advancement. Large genome sequencing projects are being instigated across the world. One example of this We develop methods for extracting new biomedical knowledge from the wiring patterns of in the UK is the 100,000 Genomes Project which has directly impacted on the reorganisation systems-level biomedical omics data. Our new methods uncover the patterns from molecular of genomic health care particularly in the laboratory domain. Across Europe as the volume networks and the multi-scale network organization indicative of biological function, of genomic information and its impact on patients and families is increasing the importance translating the information hidden in the omics data into domain-specific knowledge. of genetic counselling as an activity is being recognised. In this presentation developments We introduce a versatile data fusion (integration) framework to address key challenges in in the UK and Europe will be used to illustrate how genetic counselling as an activity and precision medicine: better patient stratification, prediction of driver genes in cancer, and as a profession is becoming relevant to the whole of genomic health care and all health re-purposing of approved drugs to particular patients and patient groups. Our new methods professionals. This needs a close examination of the action of genetic counselling in order stem from novel network science approaches coupled with graph-regularized non-negative to maximise any benefits to patients and families particularly those with rare inherited matrix tri-factorization machine learning methods. We utilize our new methodologies for Mendelian disorders. performing other related tasks, including uncovering new cancer mechanisms and disease re-classification from modern, heterogeneous molecular level data, also inferring new Gene GENOME SEQUENCING, GENETIC COUNSELLING Ontology relationships, and aligning multiple molecular networks. BIOMEDICAL OMICS DATA, NETWORK SCIENCE METHODS, MACHINE LEARNING, PRECISION MEDICINE CONGRESS OF THE SERBIAN GENETIC SOCIETY CONGRESS 10 11 PL – 03 Plenary lecture PL – 04 Plenary lecture UNDERSTANDING THE ROLE OF SOX STEM CELL GENES SOX GENES: FOR BETTER OR FOR WORSE… IN CANCER AND AGEING Milena Stevanović 1, 2, 3 Ander Matheu 1 Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Biodonostia Health Research Institute, San Sebastián, Spain Belgrade, Serbia 2 University of Belgrade, Faculty of Biology, Belgrade, Serbia [email protected] 3 Serbian Academy of Sciences and Arts, Belgrade, Serbia Ageing and age-related diseases are a major cause of mortality and morbidity. These include [email protected] neurodegenerative, cancer and frailty. The determinants that influence ageing and the onset of age-associated diseases are multifactorial and recent evidence showed that one of the The SOX genes encode a group of transcription factors that act as key regulators of diverse hallmarks that ageing and cancer share is the activity of adult stem cells. cellular processes. Members of the SOX gene family show dynamic and diverse expression The members of the SOX family are transcription actorf s and are well-established regulators patterns during development playing important roles ranging from blastocyst formation to of stem cell activity during development, and play relevant roles in adult tissue homeostasis differentiation into ltadu tissues and organs. SOX transcription factors are involved in multiple and regeneration. Accumulating ve idence documents that they play important ro les in events from the maintaining of stem cells pluripotency and cell fate decision to driving ageing and age-associated diseases, mainly cancer. In the talk, I will present recent results terminal differentiation of cells into specialized cell types. In addition, during adulthood SOX obtained in the laboratory characterizing the role of Sox2 and Sox9, likely the best-established transcription factors control various physiological processes. Mutations in SOXe g nes have biomarkers and regulators of stem cell activity, in those processes. been associated with severe clinical disorders, while misregulation of their expressions cause a broad range of pathological condition. Accumulating evidence suggests that SOX proteins SOX, CANCER, AGEING act as oncogenes and recent evidence points toward pro-proliferative, prosurvival and/or antidifferentiation roles of the SOX proteins. The results of long-term research of the structure, expression regulation and the function of selected SOX genes will be presented. It will include data obtained by studying the roles of SOX genes in in vitro neural differentiation of pluripotent embryonal carcinoma cells, as well as interaction of SOX transcription factors with signaling pathways active during neurogenesis and oncogenesis. Special focus will be made on ongoing research focused on the roles of SOX genes in promotion of malignant phenotype of cancer cells and maintaining of cancer stem cells. Obtained results provide novel insights into the functions of SOX genes in cancer that will help in designing novels strategies for cancer treatment. SOX GENES, NEURAL DIFFERENTIATION, SIGNALING PATHWAYS, CANCER STEM CELLS CONGRESS OF THE SERBIAN GENETIC SOCIETY CONGRESS 12 13 PL
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