Table S3. E- comprising the seven main GO categories representative of the frontier at a %5 FDR q- S-gene GO term GB# Gene Name LLR sign Gene Symbol value conn. ectoderm development 1490 AA598794 CTGF connective tissue growth factor 0.0105 78.32 GLS -1 ectoderm development 1308 AA128561 COL17A1 collagen, type XVII, alpha 1 0.0241 30.90 TFDP1 1 ectoderm development 1290 AA857098 COL5A2 collagen, type V, alpha 2 0.0373 27.36 SCN5A -1 ectoderm development 3910 N94616 LAMA4 laminin, alpha 4 0.0019 19.57 TFDP1 -1 ectoderm development 1281 T98612 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) 0.0378 19.23 SCN5A -1 ectoderm development 3918 AA677534 LAMC2 laminin, gamma 2 0.0241 16.07 TFDP1 1 ectoderm development 5629 AA932629 PROX1 prospero-related homeobox 1 0.0241 15.10 SCN5A 1 ectoderm development 3858 AA428454 KRT10 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 0.0352 13.37 SCN5A 1 ectoderm development 5351 AA476240 PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.0241 12.54 SCN5A -1 ectoderm development 5493 AI680568 PPL 0.0241 12.12 SCN5A 1 ectoderm development 1281 T98612 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) 0.0310 11.83 KRT20 -1 ectoderm development 7042 N45138 TGFB2 transforming growth factor, beta 2 0.0534 8.19 SCN5A 1 ectoderm development 1718 AI057612 DHCR24 24-dehydrocholesterol reductase 0.0241 7.29 UBE2L6 -1 ectoderm development 1999 AA433851 ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0241 5.98 SCN5A 1 ectoderm development 1638 AA478553 DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related 2) 0.0242 4.78 SCN5A 1 ectoderm development 2012 AA975768 EMP1 epithelial membrane protein 1 0.0339 4.10 SCN5A 1 ectoderm development 3860 W60057 KRT13 keratin 13 0.0280 3.27 SCN5A -1 ectoderm development 7357 AA165628 UGCG UDP-glucose ceramide glucosyltransferase 0.0394 2.56 ADAM21 -1 ectoderm development 5493 AI126713 PPL periplakin 0.0241 2.45 SCN5A 1 ectoderm development 5493 AA454209 PPL periplakin 0.0241 2.32 SCN5A 1 ectoderm development 404786 T60075 FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.0506 2.28 SCN5A -1 ectoderm development 3713 AI417983 IVL involucrin 0.0967 1.51 SCN5A 1 ectoderm development 6699 AA447835 SPRR1B small proline-rich protein 1B (cornifin) 0.0262 0.87 SCN5A 1 ectoderm development 51535 R52965 PPHLN1 periphilin 1 0.0503 0.49 KRT20 -1 excision repair cross-complementing rodent repair deficiency, complementation group ectoderm development 2068 R05503 ERCC2 0.0241 0.19 SCN5A -1 2 (xeroderma pigmentosum D) carboxylic acid transport 6509 AI131128 SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.0140 56.90 UBE2L6 1 carboxylic acid transport 6506 AA775980 SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.0029 37.92 TFDP1 -1 carboxylic acid transport 8604 H16761 SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 0.0143 29.81 TFDP1 -1 carboxylic acid transport 6576 AA676877 SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0244 25.94 UBE2L6 -1 carboxylic acid transport 54407 R27457 SLC38A2 solute carrier family 38, member 2 0.0242 22.29 SCN5A 1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- carboxylic acid transport 1645 R96610 AKR1C1 0.0104 18.68 CCR9 1 alpha)-hydroxysteroid dehydrogenase) carboxylic acid transport 54407 AA081106 SLC38A2 solute carrier family 38, member 2 0.0246 18.28 SCN5A 1 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member carboxylic acid transport 6520 AA630794 SLC3A2 0.0242 17.79 SCN5A 1 2 carboxylic acid transport 6509 AA598625 SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.0241 17.60 SCN5A 1 carboxylic acid transport 6507 AA453823 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0729 15.62 SCN5A -1 carboxylic acid transport 57709 AA992065 KIAA1613 KIAA1613 protein 0.0676 14.06 DHX32 1 carboxylic acid transport 10630 AA046430 T1A-2 lung type-I cell membrane-associated glycoprotein 0.0019 12.78 TFDP1 -1 carboxylic acid transport 81539 AA449481 SLC38A1 solute carrier family 38, member 1 0.0303 9.73 SCN5A 1 carboxylic acid transport 117247 W32409 SLC16A10 solute carrier family 16 (monocarboxylic acid transporters), member 10 0.0235 8.77 TFDP1 -1 carboxylic acid transport 8140 AA419177 SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.0242 7.65 SCN5A 1 carboxylic acid transport 81539 R66556 SLC38A1 solute carrier family 38, member 1 0.0241 5.81 SCN5A 1 carboxylic acid transport 10166 AA035452 SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.0241 5.38 SCN5A -1 carboxylic acid transport 81539 R45292 SLC38A1 solute carrier family 38, member 1 0.0256 4.84 SCN5A 1 carboxylic acid transport 6541 R28280 SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0241 4.45 SCN5A 1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- carboxylic acid transport 1645 R93124 AKR1C1 0.0677 3.03 SCN5A 1 alpha)-hydroxysteroid dehydrogenase) carboxylic acid transport 9123 AA129777 SLC16A3 solute carrier family 16 (monocarboxylic acid transporters), member 3 0.0241 2.06 SCN5A 1 carboxylic acid transport 81539 AA452816 SLC38A1 solute carrier family 38, member 1 0.0241 1.65 SCN5A 1 carboxylic acid transport 10166 N76599 SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.0363 1.01 SCN5A 1 carboxylic acid transport 9122 R73003 SLC16A4 solute carrier family 16 (monocarboxylic acid transporters), member 4 0.0241 0.42 SCN5A 1 negative regulation of 2619 AA292054 GAS1 growth arrest-specific 1 0.0241 21.81 SCN5A 1 mitotic cell cycle negative regulation of 2296 AA495846 FOXC1 forkhead box C1 0.0241 12.36 SCN5A 1 mitotic cell cycle negative regulation of 322 H28119 APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.0246 9.30 SCN5A -1 mitotic cell cycle negative regulation of 323 W80706 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) 0.0241 8.52 GLS 1 mitotic cell cycle negative regulation of 7040 R36467 TGFB1 transforming growth factor, beta 1 (Camurati-Engelmann disease) 0.0241 7.50 SCN5A 1 mitotic cell cycle negative regulation of 9787 AA262211 DLG7 discs, large homolog 7 (Drosophila) 0.0098 7.38 UBE2L6 -1 mitotic cell cycle negative regulation of 5119 N27227 PCOLN3 procollagen (type III) N-endopeptidase 0.0241 7.26 SCN5A -1 mitotic cell cycle negative regulation of 4088 AI074534 SMAD3 SMAD, mothers against DPP homolog 3 (Drosophila) 0.0510 4.48 SCN5A 1 mitotic cell cycle negative regulation of 9787 W93717 DLG7 discs, large homolog 7 (Drosophila) 0.0241 4.29 SCN5A -1 mitotic cell cycle response to biotic stimulus 4600 AA286908 MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.0000 216.65 CCR9 1 response to biotic stimulus 4599 AA456886 MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.0000 144.18 NARG1 1 response to biotic stimulus 23586 AA126958 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.0000 119.94 CCR9 1 response to biotic stimulus 91543 T95113 RSAD2 radical S-adenosyl methionine domain containing 2 0.0090 92.81 CCR9 1 response to biotic stimulus 9636 AA406020 G1P2 interferon, alpha-inducible protein (clone IFI-15K) 0.0000 72.35 CCR9 1 response to biotic stimulus 4938 AA146773 OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.0000 54.51 CCR9 1 response to biotic stimulus 5788 H74265 PTPRC protein tyrosine phosphatase, receptor type, C 0.0241 34.66 TFDP1 -1 response to biotic stimulus 6387 AI655374 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.0099 25.69 KRT20 -1 response to biotic stimulus 5359 N25945 PLSCR1 phospholipid scramblase 1 0.0241 14.85 SCN5A 1 response to biotic stimulus 5359 AI049711 PLSCR1 phospholipid scramblase 1 0.0241 13.83 SCN5A 1 response to biotic stimulus 3669 AA479795 ISG20 interferon stimulated gene 20kDa 0.0241 11.43 TFDP1 1 response to biotic stimulus 7852 T62491 CXCR4 chemokine (C-X-C motif) receptor 4 0.0241 9.02 SCN5A 1 response to biotic stimulus 2268 AA256231 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.0241 8.55 SCN5A -1 response to biotic stimulus 23586 AA682834 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.0310 8.55 SCN5A 1 response to biotic stimulus 5610 AA010079 EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0241 8.15 ADAM21 1 response to biotic stimulus 664 AA010383 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0645 7.18 KRT20 -1 response to biotic stimulus 6356 W69211 CCL11 chemokine (C-C motif) ligand 11 0.0262 6.91 SCN5A -1 response to biotic stimulus 85363 H04279 TRIM5 tripartite motif-containing 5 0.0241 2.21 SCN5A 1 steroid metabolic process 51141 AA045308 INSIG2 insulin induced gene 2 0.0219 160.20 SEC24D 1 steroid metabolic process 6342 AA664009 SCP2 sterol carrier protein 2 0.0241 75.32 EIF2AK2 1 steroid metabolic process 6646 AI139693 SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 0.0038 52.95 TFDP1 -1 steroid metabolic process 57016 AI301329 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0407 52.87 GNAI3 1 steroid metabolic process 338 H57779 APOB apolipoprotein B (including Ag(x) antigen) 0.0000 50.23 ADAM9 -1 steroid metabolic process 1589 T61078 CPS1 carbamoyl-phosphate synthetase 1, mitochondrial 0.0241 39.86 SCN5A -1 steroid metabolic process 8856 AI017332 PAR1 Prader-Willi/Angelman region-1 0.0241 39.84 ADAM21 -1 steroid metabolic process 83666 N50904 PARP9 poly (ADP-ribose) polymerase family, member 9 0.0029 34.68 ADAM9 1 steroid metabolic process 1589 W88718 CPS1 carbamoyl-phosphate synthetase 1, mitochondrial 0.0118 20.04 GNAI3 1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- steroid metabolic process 1645 R96610 AKR1C1 0.0104 18.68 CCR9 1 alpha)-hydroxysteroid dehydrogenase) steroid metabolic process 6646 R07295 SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 0.0241 16.19 SCN5A 1 steroid metabolic process 3156 AA779417 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.0105 15.80 UBE2L6 -1 steroid metabolic process 1071 R19276 CETP cholesteryl ester transfer protein, plasma 0.0102 13.12 KRT20 -1 steroid metabolic process 338 T53122 APOB apolipoprotein B (including Ag(x) antigen) 0.0733 12.90 ADAM21 -1 steroid metabolic process 1577 AA702706 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0099 12.69 KRT20 1 steroid metabolic process 3157 N62195 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.0242 12.14 UBE2L6 -1 steroid metabolic process 7436 W94809 VLDLR very low density lipoprotein receptor 0.0583 11.58 SCN5A 1 steroid metabolic process 5617 AA133920 PRL prolactin 0.0241 11.57 SCN5A 1 steroid metabolic process 1717 AI652764 DHCR7 7-dehydrocholesterol reductase 0.0105 11.38 UBE2L6 -1 steroid metabolic process 56654 AI369785 NPDC1 neural proliferation, differentiation and control, 1 0.0241 8.18 SCN5A 1 steroid metabolic process 1718 AI057612 DHCR24 24-dehydrocholesterol reductase 0.0241 7.29 UBE2L6 -1 steroid metabolic process 3422 N23961 IDI1 isopentenyl-diphosphate delta isomerase 0.0241 6.59 SCN5A -1 steroid metabolic process 3157 AA279533 HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 0.0241 5.74 UBE2L6 -1 steroid metabolic process 51302 W01800 CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.0608 5.57 KRT20 1 steroid metabolic process 51360 R53421 MBTPS2 membrane-bound transcription factor protease, site 2 0.0105 3.50 KRT20 -1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- steroid metabolic process 1645 R93124 AKR1C1 0.0677 3.03 SCN5A 1 alpha)-hydroxysteroid dehydrogenase) steroid metabolic process 1588 AA678058 CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.0241 0.11 SCN5A 1 steroid metabolic process 3158 AA496149 HMGCS2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) 0.0724 0.02 KRT20 1 cell migration 55704 AI022231 KIAA1212 KIAA1212 0.0019 144.86 DHX32 -1 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) cell migration 57556 N63533 SEMA6A 0.0055 67.72 GLS -1 6A cell migration 4897 R37780 NRCAM neuronal cell adhesion molecule 0.0241 55.07 UBE2L6 1 cell migration 83666 N50904 PARP9 poly (ADP-ribose) polymerase family, member 9 0.0029 34.68 ADAM9 1 cell migration 6850 AA598572 SYK spleen tyrosine kinase 0.0254 28.50 SCN5A 1 cell migration 6286 R32952 S100P S100 calcium binding protein P 0.0241 27.96 UBE2L6 1 cell migration 8828 AA490279 NRP2 neuropilin 2 0.0134 25.74 TFDP1 -1 cell migration 694 N70463 BTG1 B-cell translocation gene 1, anti-proliferative 0.0241 23.67 SCN5A 1 cell migration 2335 N26285 FN1 fibronectin 1 0.0252 20.60 GLS 1 cell migration 55704 N62638 KIAA1212 KIAA1212 0.0029 18.76 TFDP1 -1 cell migration 7424 H07991 VEGFC vascular endothelial growth factor C 0.0099 18.76 KRT20 -1 cell migration 3156 AA779417 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.0105 15.80 UBE2L6 -1 cell migration 357 H49455 APXL apical protein-like (Xenopus laevis) 0.0241 13.24 SCN5A -1 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) cell migration 57556 AI284976 SEMA6A 0.0038 12.26 TFDP1 -1 6A cell migration 1794 H72959 DOCK2 dedicator of cytokinesis 2 0.0241 11.65 SCN5A -1 AK09130 cell migration 2335 R62612 FN1 fibronectin 1 0.0728 10.31 -1 8 cell migration 5646 AI214435 PRSS3 protease, serine, 3 (mesotrypsin) 0.0109 9.19 TFDP1 1 cell migration 6359 H62013 CCL15 chemokine (C-C motif) ligand 15 0.0241 8.40 SCN5A 1 cell migration 7042 N45138 TGFB2 transforming growth factor, beta 2 0.0534 8.19 SCN5A 1 cell migration 2335 N73836 FN1 fibronectin 1 0.0241 6.81 KRT20 1 cell migration 1794 N70765 DOCK2 dedicator of cytokinesis 2 0.0967 6.81 CCR9 -1 cell migration 6586 H41160 SLIT3 slit homolog 3 (Drosophila) 0.0639 6.33 TFDP1 1 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) cell migration 57556 N21368 SEMA6A 0.0248 6.05 KRT20 -1 6A cell migration 58191 AA416552 CXCL16 chemokine (C-X-C motif) ligand 16 0.0241 5.77 SCN5A 1 cell migration 9270 AA456882 ITGB1BP1 integrin beta 1 binding protein 1 0.0099 4.95 KRT20 -1 cell migration 8613 T72119 PPAP2B phosphatidic acid phosphatase type 2B 0.0256 3.11 SCN5A -1 SERPINA serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), cell migration 5267 AA628410 0.0241 2.72 SCN5A 1 4 member 4 cell migration 6586 AA488181 SLIT1 slit homolog 1 (Drosophila) 0.0337 2.46 SCN5A 1 cell migration 3915 AI188320 LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0241 0.91 KRT20 1 cell migration 9378 AA927036 NRXN1 neurexin 1 0.0241 0.27 SCN5A 1 cell migration 55704 AA497044 KIAA1212 KIAA1212 0.0241 0.23 SCN5A -1 regulation of Wnt receptor 5518 AA427688 PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.0000 20.81 GLS -1 signaling pathway regulation of Wnt receptor 27122 AA425947 DKK3 dickkopf homolog 3 (Xenopus laevis) 0.0107 14.71 TFDP1 -1 signaling pathway regulation of Wnt receptor 22943 AA253464 DKK1 dickkopf homolog 1 (Xenopus laevis) 0.0241 9.33 GLS -1 signaling pathway regulation of Wnt receptor 83439 AA026102 TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.0519 3.19 SCN5A 1 signaling pathway regulation of Wnt receptor 29969 N79548 MDFIC MyoD family inhibitor domain containing 0.0107 2.08 KRT20 -1 signaling pathway