Table S3. E-genes comprising the seven main GO categories representative of the frontier at a %5 FDR Entrez Gene q- S-gene GO term GB# Gene Name LLR sign Gene Symbol value conn. ectoderm development 1490 AA598794 CTGF connective tissue growth factor 0.0105 78.32 GLS -1 ectoderm development 1308 AA128561 COL17A1 collagen, type XVII, alpha 1 0.0241 30.90 TFDP1 1 ectoderm development 1290 AA857098 COL5A2 collagen, type V, alpha 2 0.0373 27.36 SCN5A -1 ectoderm development 3910 N94616 LAMA4 laminin, alpha 4 0.0019 19.57 TFDP1 -1 ectoderm development 1281 T98612 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) 0.0378 19.23 SCN5A -1 ectoderm development 3918 AA677534 LAMC2 laminin, gamma 2 0.0241 16.07 TFDP1 1 ectoderm development 5629 AA932629 PROX1 prospero-related homeobox 1 0.0241 15.10 SCN5A 1 ectoderm development 3858 AA428454 KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 0.0352 13.37 SCN5A 1 ectoderm development 5351 AA476240 PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.0241 12.54 SCN5A -1 ectoderm development 5493 AI680568 PPL periplakin 0.0241 12.12 SCN5A 1 ectoderm development 1281 T98612 COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) 0.0310 11.83 KRT20 -1 ectoderm development 7042 N45138 TGFB2 transforming growth factor, beta 2 0.0534 8.19 SCN5A 1 ectoderm development 1718 AI057612 DHCR24 24-dehydrocholesterol reductase 0.0241 7.29 UBE2L6 -1 ectoderm development 1999 AA433851 ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0241 5.98 SCN5A 1 ectoderm development 1638 AA478553 DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) 0.0242 4.78 SCN5A 1 ectoderm development 2012 AA975768 EMP1 epithelial membrane protein 1 0.0339 4.10 SCN5A 1 ectoderm development 3860 W60057 KRT13 keratin 13 0.0280 3.27 SCN5A -1 ectoderm development 7357 AA165628 UGCG UDP-glucose ceramide glucosyltransferase 0.0394 2.56 ADAM21 -1 ectoderm development 5493 AI126713 PPL periplakin 0.0241 2.45 SCN5A 1 ectoderm development 5493 AA454209 PPL periplakin 0.0241 2.32 SCN5A 1 ectoderm development 404786 T60075 FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.0506 2.28 SCN5A -1 ectoderm development 3713 AI417983 IVL involucrin 0.0967 1.51 SCN5A 1 ectoderm development 6699 AA447835 SPRR1B small proline-rich protein 1B (cornifin) 0.0262 0.87 SCN5A 1 ectoderm development 51535 R52965 PPHLN1 periphilin 1 0.0503 0.49 KRT20 -1 excision repair cross-complementing rodent repair deficiency, complementation group ectoderm development 2068 R05503 ERCC2 0.0241 0.19 SCN5A -1 2 (xeroderma pigmentosum D) carboxylic acid transport 6509 AI131128 SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.0140 56.90 UBE2L6 1 carboxylic acid transport 6506 AA775980 SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.0029 37.92 TFDP1 -1 carboxylic acid transport 8604 H16761 SLC25A12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 0.0143 29.81 TFDP1 -1 carboxylic acid transport 6576 AA676877 SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.0244 25.94 UBE2L6 -1 carboxylic acid transport 54407 R27457 SLC38A2 solute carrier family 38, member 2 0.0242 22.29 SCN5A 1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- carboxylic acid transport 1645 R96610 AKR1C1 0.0104 18.68 CCR9 1 alpha)-hydroxysteroid dehydrogenase) carboxylic acid transport 54407 AA081106 SLC38A2 solute carrier family 38, member 2 0.0246 18.28 SCN5A 1 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member carboxylic acid transport 6520 AA630794 SLC3A2 0.0242 17.79 SCN5A 1 2 carboxylic acid transport 6509 AA598625 SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.0241 17.60 SCN5A 1 carboxylic acid transport 6507 AA453823 SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0729 15.62 SCN5A -1 carboxylic acid transport 57709 AA992065 KIAA1613 KIAA1613 protein 0.0676 14.06 DHX32 1 carboxylic acid transport 10630 AA046430 T1A-2 lung type-I cell membrane-associated glycoprotein 0.0019 12.78 TFDP1 -1 carboxylic acid transport 81539 AA449481 SLC38A1 solute carrier family 38, member 1 0.0303 9.73 SCN5A 1 carboxylic acid transport 117247 W32409 SLC16A10 solute carrier family 16 (monocarboxylic acid transporters), member 10 0.0235 8.77 TFDP1 -1 carboxylic acid transport 8140 AA419177 SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.0242 7.65 SCN5A 1 carboxylic acid transport 81539 R66556 SLC38A1 solute carrier family 38, member 1 0.0241 5.81 SCN5A 1 carboxylic acid transport 10166 AA035452 SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.0241 5.38 SCN5A -1 carboxylic acid transport 81539 R45292 SLC38A1 solute carrier family 38, member 1 0.0256 4.84 SCN5A 1 carboxylic acid transport 6541 R28280 SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0241 4.45 SCN5A 1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3- carboxylic acid transport 1645 R93124 AKR1C1 0.0677 3.03 SCN5A 1 alpha)-hydroxysteroid dehydrogenase) carboxylic acid transport 9123 AA129777 SLC16A3 solute carrier family 16 (monocarboxylic acid transporters), member 3 0.0241 2.06 SCN5A 1 carboxylic acid transport 81539 AA452816 SLC38A1 solute carrier family 38, member 1 0.0241 1.65 SCN5A 1 carboxylic acid transport 10166 N76599 SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.0363 1.01 SCN5A 1 carboxylic acid transport 9122 R73003 SLC16A4 solute carrier family 16 (monocarboxylic acid transporters), member 4 0.0241 0.42 SCN5A 1 negative regulation of 2619 AA292054 GAS1 growth arrest-specific 1 0.0241 21.81 SCN5A 1 mitotic cell cycle negative regulation of 2296 AA495846 FOXC1 forkhead box C1 0.0241 12.36 SCN5A 1 mitotic cell cycle negative regulation of 322 H28119 APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.0246 9.30 SCN5A -1 mitotic cell cycle negative regulation of 323 W80706 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) 0.0241 8.52 GLS 1 mitotic cell cycle negative regulation of 7040 R36467 TGFB1 transforming growth factor, beta 1 (Camurati-Engelmann disease) 0.0241 7.50 SCN5A 1 mitotic cell cycle negative regulation of 9787 AA262211 DLG7 discs, large homolog 7 (Drosophila) 0.0098 7.38 UBE2L6 -1 mitotic cell cycle negative regulation of 5119 N27227 PCOLN3 procollagen (type III) N-endopeptidase 0.0241 7.26 SCN5A -1 mitotic cell cycle negative regulation of 4088 AI074534 SMAD3 SMAD, mothers against DPP homolog 3 (Drosophila) 0.0510 4.48 SCN5A 1 mitotic cell cycle negative regulation of 9787 W93717 DLG7 discs, large homolog 7 (Drosophila) 0.0241 4.29 SCN5A -1 mitotic cell cycle response to biotic stimulus 4600 AA286908 MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.0000 216.65 CCR9 1 response to biotic stimulus 4599 AA456886 MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.0000 144.18 NARG1 1 response to biotic stimulus 23586 AA126958 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.0000 119.94 CCR9 1 response to biotic stimulus 91543 T95113 RSAD2 radical S-adenosyl methionine domain containing 2 0.0090 92.81 CCR9 1 response to biotic stimulus 9636 AA406020 G1P2 interferon, alpha-inducible protein (clone IFI-15K) 0.0000 72.35 CCR9 1 response to biotic stimulus 4938 AA146773 OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.0000 54.51 CCR9 1 response to biotic stimulus 5788 H74265 PTPRC protein tyrosine phosphatase, receptor type, C 0.0241 34.66 TFDP1 -1 response to biotic stimulus 6387 AI655374 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.0099 25.69 KRT20 -1 response to biotic stimulus 5359 N25945 PLSCR1 phospholipid scramblase 1 0.0241 14.85 SCN5A 1 response to biotic stimulus 5359 AI049711 PLSCR1 phospholipid scramblase 1 0.0241 13.83 SCN5A 1 response to biotic stimulus 3669 AA479795 ISG20 interferon stimulated gene 20kDa 0.0241 11.43 TFDP1 1 response to biotic stimulus 7852 T62491 CXCR4 chemokine (C-X-C motif) receptor 4 0.0241 9.02 SCN5A 1 response to biotic stimulus 2268 AA256231 FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.0241 8.55 SCN5A -1 response to biotic stimulus 23586 AA682834 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.0310 8.55 SCN5A 1 response to biotic stimulus 5610 AA010079 EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0241 8.15 ADAM21 1 response to biotic stimulus 664 AA010383 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0645 7.18 KRT20 -1 response to biotic stimulus 6356 W69211 CCL11 chemokine (C-C motif) ligand 11 0.0262 6.91 SCN5A -1 response to biotic stimulus 85363 H04279 TRIM5 tripartite motif-containing 5 0.0241 2.21 SCN5A 1 steroid metabolic process 51141 AA045308 INSIG2 insulin induced gene 2 0.0219 160.20 SEC24D 1 steroid metabolic process 6342 AA664009 SCP2 sterol carrier protein 2 0.0241 75.32 EIF2AK2 1 steroid metabolic process 6646 AI139693 SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 0.0038 52.95 TFDP1 -1 steroid metabolic process 57016 AI301329 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0407 52.87 GNAI3 1 steroid