Dear Colleagues, Welcome to the 20th Annual Meeting of the Federation of Clinical Immunology Societies, FOCIS 2020, and the first- ever virtual offering of THE meeting in translational immunology. The FOCIS 2020 Scientific Program is presented by world-renowned leaders from academia and industry presenting new developments in immune therapies, immune diseases, and developing technologies to measure and assess the immune system. Participants will share in best practices for data sharing and assay standardization and the rapid emergence of ever-evolving technologies, and the application of immunological discovery to the challenges facing our global community, that includes the COVID-19 pandemic. This year FOCIS celebrates its 20th anniversary. Since its inception in 2001, FOCIS has continued to strengthen its interdisciplinary approach to clinical immunology and broaden its scope in pursuit of our mission to improve human health through immunology. In our 20th year, FOCIS has 59 Member Societies and 1,000 individual members bridging multiple disciplines with a common focus on immune-mediated disease. The FOCIS Annual Meeting is the leading forum for researchers and clinicians from a multitude of specialties, along with industry and governmental representatives, to come together and share the latest breakthroughs. We value the participation of each of you who have contributed to FOCIS’ success over the past 20 years, and we know that you will continue to empower the efforts of our community to secure the future of the field. We encourage you to get involved in FOCIS. Join FOCIS as a member and join our efforts to promote education, research, and clinical care through translational immunology. Please join me in extending our most heartfelt thanks to the members of the FOCIS 2020 Scientific Program Committee for their time, energy, and expertise that helped put together a world class line up of speakers and topics. We hope you enjoy the fruits of their labor – FOCIS 2020. Thank you, once again, for taking part in FOCIS 2020 and for helping to further the mission of FOCIS. Welcome to our virtual meeting! Sincerely, Mark Anderson, MD, PhD, FOCIS President University of California, San Francisco 2 FOCIS 2020 Supporters FOCIS gratefully acknowledges the support that allows FOCIS to fulfill its mission to foster interdisciplinary approaches to both understand and treat immune-based diseases, and ultimately to improve human health through immunology. DIAMOND SPONSOR PLATINUM SPONSOR GOLD SPONSORS Bio Cell SILVER SPONSORS BRONZE SPONSORS COPPER SPONSORS 3 FOCIS 2020 Scientific Program Committee Jacques Banchereau, PhD Jane Grogan, PhD Kavita Dhodapkar, MD Mark Anderson, MD, PhD The Jackson Laboratory ArsenalBio Emory University University of California, for Genomic Medicine Abstract Chair Abstract Co-Chair San Francisco Chair Jeffrey Bluestone, PhD Silvia Gregori, PhD Nir Hacohen, PhD Jonathan Maltzman, MD, PhD Sonoma Biotherapeutics San Raffaele Telethon Massachusetts Stanford University Institute for Gene Therapy General Hospital Jordan Pober, MD, PhD William Robinson, MD Maria-Grazia Roncarolo, MD Yale University Stanford University Stanford University FOCIS 2020 General Information Evaluations Delegates will receive email reminders and links to the evaluations during the meeting. Evaluations are also accessible through the mobile app. Poster Presentation Hours Thursday, October 29, 2:30 PM – 4:30 PM PT Friday, October 30, 2:30 PM – 4:30 PM PT Release Registration and attendance at, or participation in, FOCIS meetings and other activities constitutes an agreement by the registrant to FOCIS’ use and distribution (both now and in the future) of the registrant or attendee’s image or voice in photographs, videotapes, electronic reproductions and audio tapes of such events and activities. 4 OCTOBER 28-31•2020 VIRTUAL ANNUAL MEETING 7:00 am – 10:20 am Member Society Symposia Environmental Effects on Immune Response Diversity Chairs: Darragh Duffy, PhD, Stanford University; Matthew Albert, MD, PhD, Insitro Organized by Milieu Interieur in partnership with Myriad RBM 7:00 am Differential Effects of Past and Active Smoking on Innate and Adaptive Immunity Darragh Duffy, PhD, Institut Pasteur 7:35 am Early Life Microbiome, Immune Printing and Childhood Health Susan Lynch, PhD, University of California, San Francisco SCIENTIFIC PROGRAM 8:10 am Heterogeneity in Data: A Blessing in Disguise for Accelerating Translational Medicine Purvesh Khatri, PhD, Stanford University All times listed are in US Pacific Daylight 8:45 am Break Time (PT), 7 hours behind UTC. 9:00 am Systems Immunology of Natural and Engineered Wednesday, October 28 Adjuvants John Tsang, PhD, National Institutes of Health 7:00 am – 4:00 pm 9:35 am Study of Natural Immune Variability to Dissect Systems Immunology Course Cytokine Response Pathways (separate registration required) Celine Posseme, Institut Pasteur 8:00 am – 4:30 pm 9:50 am Immune Variation and Protection Against Infection Following Iatrogenic Exposure to Hepatitis C Virus Cancer Immunity and Immunotherapy Course Jamie Sugrue, Trinity College Dublin (separate registration required) 10:05 am Developing a Whole Blood Stimulation System to Predict Glucocorticoid Responsiveness in Patients Organized in with Autoimmune Disease collaboration with Madeleine Stimpson, PhD, University of Bristol 8:30 am – 5:30 pm Basic Immunology in Medicine: Update 2020 Course (separate registration required) 5 Tuesday 7:00 am – 11:00 am 8:45 am Negative Checkpoint Receptors in Organ Specific Going Viral: Modulation of Alloresponses by Viral Autoimmunity and Tolerance Infections Ricardo Pujol Borrell, MD, PhD, Hospital Universitari Chairs: Fadi Issa, DPhil, University of Oxford; Jonathan Vall d'Hebron Maltzman, MD, PhD, Stanford University; Elaine Reed, PhD, 9:15 am Immunotherapy in Noninfectious University of California, Los Angeles Immuno-mediated Uveitis José María Ruiz de Morales, MD, PhD, Complejo Hospitalario Universitario de Leýÿn Organized by 9:45 am Identifying Changes in Peripheral Lymphocyte Subpopulations at the Onset of Adult Type 1 Diabetes and their Long-term Evolution Aina Teniente-Serra, PhD, Hospital Universitari 7:00 am Pseudomonas Aeruginosa and Acute Rejection Germans Trias i Pujol Independently Increase the Risk of Donor-specific 10:00 am The Role of HLA-DR Expression on Monocytes Antibodies after Lung Transplantation and Sepsis Index as Predictive Sepsis Biomarkers Ramsey Hachem, MD, Washington University Bibiana Quiránt Sanchez, MBA, Universitat Autònoma de Barcelona 7:30 am BK Virus and Alloimmune Responses Parmjeet Randhawa, MD, University of Pittsburgh 10:15 am Cytokine Profile of COVID-19-related MIS-C Medical Center Compared with Pre-pandemic Kawasaki Disease and SARS-CoV-2 Specific Immune Complexes 8:00 am T cell Responses to CMV in Transplant Recipients Detection in MIS-C Jonathan Maltzman, MD, PhD, Stanford University Ana Esteve-Sole, Hospital Sant Joan de Déu 8:30 am Flu Specific B cell Populations in Human Tissue 10:30 am Multi-biomarker Integration Enables a Powerful Anoma Nellore, MD, University of Alabama Classification of Long-term Survivors with Normal at Birmingham Allograft Function after Lung Transplantation Albert Mendoza-Valderrey, Vall d'Hebron 9:00 am Break Research Institute 9:30 am Epigenetic Age in Kidney Transplant Patients as a Tool for Improving Age-related Infectious 11:00 am – 2:30 pm Complications of Immunosuppression Member Society Symposia Joanna Schaenman, MD, PhD, University 11:00 am – 2:30 pm of California, Los Angeles Big Data Immunology in Uveitis 10:00 am Evolutionary Responses to Viral Infections and Chairs: Phoebe Lin, MD, PhD, Oregon Health & Science Impact on Human Health University; Kathryn Pepple, MD, PhD, University of Washington Shane Grey, PhD, Garvan Institute of Medical Organized by Research 11:00 am Introduction 10:30 am Question and Answer Period and Wrap Up Phoebe Lin, MD, PhD Oregon Health & Science University 7:00 am – 10:45 am 11:05 am Utility of Single cell RNA Sequencing in Symposium on Tolerance in Transplantation, Noninfectious Uveitis Autoimmunity and Cancer Lynn Hassman, MD, PhD, Washington University Chairs: Eva María Martinez-Cáceres, MD, PhD, Universitat Autònoma de Barcelona; Ricardo Pujol Borrell, MD, PhD, 11:25 am Characterization of Sarcoidosis using Hospital Universitari Vall d'Hebron Metagenomic Deep Sequencing John Gonzales, MD, University of California, San Francisco Organized by 11:45 am Antibiotic Resistance in Azithromycin Treatment in Africa using MDS Thuy Doan, MD, PhD, University of California, San Francisco 7:00 am Spanish Society of Immunology (SEI) actions on the COVID-19 pandemic 12:05 pm Mass Cytometry Multiplexed Imaging Africa Gonzalez, MD, PhD, University of Vigo Valeria Ramaglia, PhD, University of Toronto 7:30 am Trained Immunity as a Therapeutic Target in 12:25 pm Panel Discussion Cancer and Transplantation 12:35 pm Break Jordi Ochando, PhD, Ichan School of Medicine 12:50 pm High Dimensional Profiling and Immune at Mount Sinai Monitoring of Uveitis Patient 8:15 am Cellular Immunotherapy in Autoimmunity and Pulak Nath, PhD, The Jackson Laboratory Multiple Sclerosis 1:10 pm Milieu Intérieur: Defining the Boundaries of Eva María Martinez-Cáceres, MD, PhD, Universitat a Healthy Immune Response for a Better Autònoma de Barcelona Understanding of Disease Darragh Duffy, PhD, Institut Pasteur 6 1:30 pm Using Crowd-sourced Data in Autoimmunity 12:45 pm Break John Tsang, PhD, National Institutes of Health 1:00 pm Mononuclear Phagocytes