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Home , ADAM8, APOL6, CCL13, CCL15, CCL7, CD163

Supplementary Table 3. List of defined in the literature as significant in -to- differentiation and polarization. Reported Symbol Name ID Expression Reference ADAM8 A and domain 8 101 M2 (1) ADK Adenosine kinase 132 M2 (2) AK3 Adenylate kinase 3 50808 M1 (2) ALOX15 Arachidonate 15-lipoxygenase 246 M2 (3) APOL1 L, 1 8542 M1 (2) APOL2 Apolipoprotein L, 2 23780 M1 (2) APOL3 Apolipoprotein L, 3 80833 M1 (2) APOL6 Apolipoprotein L, 6 80830 M1 (2) ARG1 Arginase, 383 M2 (4) ARG2 Arginase, type II 384 M2 (5) ATF3 Activating 3 467 M1 (2) BCL2A1 BCL2-related A1 597 M1 (2) BID BH3 interacting domain death agonist 637 Monocyte (2) BIRC3 Baculoviral IAP repeat-containing 3 330 M1 (2) CA2 Carbonic anhydrase II 760 M2 (2) CAT Catalase 847 M2 (6) CAT2 Solute carrier family 7 (cationic transporter, y+ system), member 2 6542 M2 (6) CCL1 (C-C motif) 1 6346 M2 (4) CCL11 Chemokine ligand 11, Eotaxin 6356 M1 (4) CCL13 Chemokine ligand13, MCP-4 6357 M2 (2) CCL15 Chemokine (C-C motif) ligand 15 6359 M1 (2) CCL17 Chemokine ligand17, TARC 6361 M1 & M2 (4) CCL18 Chemokine ligand 18, MIP-4 6362 M2 (4) CCL19 Chemokine ligand 19, MIP-3B 6363 M1 (2) CCL2 Chemokine ligand 2, MCP1, GDCF-2 6347 Macrophage (2) CCL20 Chemokine ligand 20, MIP-3A 6364 M1 (2) CCL22 Chemokine ligand 22, MDC 6367 M2 (7) CCL23 Chemokine (C-C motif) ligand 23 6368 M2 (2) CCL24 Chemokine ligand 24 6369 M2 (4) CCL25 Chemokine ligand 25 6370 M2 (8) CCL3 Chemokine ligand 3, MIP-1A 6348 M1 (4) CCL4 Chemokine ligand 4, MIP-1B 6351 M1 (4) CCL5 Chemokine ligand 5, RANTES 6352 M1 (4) CCL7 Chemokine ligand 7, MARC, MCP-3 6354 M2 (8) CCL8 Chemokine ligand 8, MCP-2 6355 M1 (2) CCN1 -rich, angiogenic inducer, 61 3491 M2 (1) CCR1 Chemokine (C-C motif) 1 1230 M1 & M2 (4) CCR2 2 1231 Monocyte (4) CCR3 Chemokine receptor 3, CD193 1232 M1 & M2 (8) CCR5 Chemokine receptor 5, CD195 1234 M1 & M2 (4) CCR7 Chemokine receptor 7, CD197 1236 M1 (8) CCR9 Chemokine receptor 9 10803 M1 & M2 (8) CD115 CSF-1R 1436 M2 (8) CD11b , alpha M; Itgam 3684 M2 (1) CD11c Integrin, alpha X; Itgax 3687 M1 (8) CD14 Monocyte differentiation antigen CD14; myeloid cell-specific 929 Monocyte, M2 (9) CD16 FCGR3A, Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 2214 M1 (4) CD163 CD163 molecule 9332 M2 (10) CD204 Macrophage scavenger receptor 1, MSR1 4481 M2 (1) CD206 C type 1, MRC1 4360 M2 (4) CD23A FCER2, Fc fragment of IgE, low affinity II, receptor for (CD23) 2208 M2 (3) CD28 CD28 molecule 940 Macrophage (2) CD36 Leukocyte differentiation antigen 948 M2 (2) CD44 CD44 molecule 960 Macrophage (11) CD47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 961 M1 (3) CD68 CD68 molecule 968 M1 & M2 (7) CD74 CD74 molecule, Major histocompatibility complex, class II invariant chain 972 M1 (7) CD80 CD28LG, B- activation antigen B7 941 M1 (7) CD83 CD83 molecule 9308 Monocyte (2) CD86 CD86 molecule, CD28LG2 942 M1 (7) CDA Cytidine deaminase 978 Macrophage (2) CDC2 Cell division cycle 2, G1 to S and G2 to M 983 Macrophage (2) CDC20 Cell division cycle 20 homolog (S. cerevisiae) 991 Macrophage (2) CDH1 1, type 1, E-cadherin (epithelial) 999 M2 (3) CDKN1C Cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1028 Monocyte (2) CDKN3 Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) 1033 M1 (2) CERK Ceramide kinase 64781 M2 (2) CHI3L2 Chitinase 3-like 2 1117 M1 (2) CHN2 Chimerin (chimaerin) 2 1124 M2 (2) CLEC7A C-type lectin domain family 7, member A; Dectin 1 64581 M2 (2) CLECSF13 CLEC4F, C-type lectin domain family 4, member F 165530 M2 (2) CRLF2 receptor-like factor 2 64109 M1 (12) CSF-1 Colony stimulating factor 1 (MF), MCSF 1435 M2 (1) CSF-2 Colony stimulating factor 2 (-macrophage), GMCSF 1437 M1 (2) CSPG2 VCAN, versican 1462 M1 (2) CTSB Cathepsin B 1508 M1 & M2 (1) CTSC Cathepsin C 1075 M2 (2) CX3CR1 Chemokine (C-X3-C motif) receptor 1 1524 Monocyte (4) CXCL1 Chemokine (C-X-C motif) ligand 1 2919 M1 (4) CXCL10 Chemokine ligand 10, IP-10 3627 M1 (4) CXCL11 Chemokine (C-X-C motif) ligand 11 6373 M1 (9) CXCL16 Chemokine ligand 16 58191 M1 (9) CXCL2 Chemokine ligand 2 2920 M1 (4) CXCL3 Chemokine (C-X-C motif) ligand 3 2921 M1 (4) CXCL5 Chemokine ligand 5, ENA-78 6374 M1 (4) CXCL8/IL-8 C-X-C motif chemokine 8, T-cell chemotactic factor; beta-thromboglobulin-like protein 3576 M1 (4) CXCL9 Chemokine ligand 9 4283 M1 (2) CXCR1 Chemokine (C-X-C motif) receptor 1 3577 M2 (9) CXCR2 Chemokine receptor 2, CD182, IL8RA 3579 M2 (9) CXCR4 Chemokine receptor 4, CD184 7852 M2 (4) DCL-1 CD302 molecule 9936 M2 (2) DCSIGN CD209 molecule 30835 M2 (2) DC-STAMP Domain containing 2, Hypothetical protein FLJ32934 127579 M2 (13) DHCR24 24-dehydrocholesterol reductase 1718 M2 (14) ECGF1 Endothelial cell 1 (-derived) 1890 M1 (2) EDN1 Endothelin 1 1906 M1 (2) EGF Epidermal growth factor 1950 M2 (1) EGR1 Early growth response 1 1958 Macrophage (15) EGR2 Early growth response 2 (Krox-20 homolog, ) 1959 M2 (2) EMR2 Egf-like module containing, mucin-like, -like 2; CD312 30817 M1 & M2 (7) Zinc finger protein 808, EMR1, Egf-like module containing, mucin-like, hormone F4/80 receptor-like 1 2015 Macrophage (1) FAS Fas (TNF receptor superfamily, member 6) 355 M1 (2) FGL2 Fibrinogen-like 2, fibroleukin 10875 M2 (2) FN1 Fibronectin 1, Zinc finger protein 706 2335 M2 (3) FXIIIA1 F8, coagulation factor VIII, procoagulant component 2157 M2 (3) GADD45G Growth arrest and DNA-damage-inducible, gamma 10912 M1 (2) GAS6 Growth arrest-specific 6 2621 M2 (3) GAS7 Growth arrest-specific 7 8522 M2 (2) GM-CSFR Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 1439 M1 (16) GPR86 P2Y, G-protein coupled 53829 M2 (2) HESX1 HESX homeobox 1 8820 M1 (2) HEXB Hexosaminidase B (beta polypeptide) 3074 M2 (2) HK3 3 (white cell) 3101 Macrophage (2) HLA-DPA1 Major histocompatibility complex, class II, DP alpha 1 3113 Monocyte (2) HLA-DPB1 Major histocompatibility complex, class II, DP beta 1 3115 Monocyte (2) HLA-DQA1 Major histocompatibility complex, class II, DQ alpha 1 3117 Monocyte (2) HLA-DQB1 Major histocompatibility complex, class II, DQ beta 1 3119 Monocyte (2) HLA-DQB2 Major histocompatibility complex, class II, DQ beta 2 3120 Monocyte (2) HLA-DQB3 Major histocompatibility complex, class II, DQ beta 3 3121 Monocyte (2) HLA-DRA Major histocompatibility complex, class II, DR alpha 3122 Monocyte (2) HLA-DRB1 Major histocompatibility complex, class II, DR beta 1 3123 Monocyte (2) HLA-DRB2 Major histocompatibility complex, class II, DR beta 2 (pseudogene) 3124 Monocyte (2) HLA-DRB4 Major histocompatibility complex, class II, DR beta 4 3126 Monocyte (2) HLA-E Major histocompatibility complex, class I, E 3133 Monocyte (2) HNMT Histamine N-methyltransferase 3176 M2 (2) HRH1 H1 3269 M2 (2) HS3ST1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 9957 M2 (2) HS3ST2 Heparan sulfate (glucosamine) 3-O-sulfotransferase 2 9956 M2 (2) HSD11B1 Hydroxysteroid (11-beta) dehydrogenase 1 3290 M1 (2) HSXIAPAF1 XIAP associated factor 1 54739 M1 (2) IFN-g , gamma 3458 M1 (17) IGF1 Insulin-like growth factor 1 (somatomedin C) 3479 M2 (2) IGFBP4 Insulin-like growth factor binding protein 4 3487 M1 (2) IL-1 1, alpha; IL-1A 3552 M1 (4) IL-10 Interleukin 10A 3586 M1 (4) IL10RA receptor, alpha 3587 Monocyte (2) IL-12 Interleukin 12A, p35 3592 M1 (4) IL12B Interleukin 12B (cytotoxic lymphocyte maturation factor 2, p40) 3593 M1 (2) IL-13 3596 M2 (18) IL-13RA1 Interleukin 13 receptor, alpha 1 3597 M2 (3) IL-13RA2 Interleukin 13 receptor, alpha 2 3598 M2 (3) IL15 3600 M1 (2) IL15RA Interleukin 15 receptor, alpha 3601 M1 (2) IL-17 Interleukin 17A, cytotoxic T-lymphocyte-associated antigen 8 3605 M2 (3) IL-18 3606 M2 (1) IL-1b Interleukin 1, beta; IL1F2 3553 M1 & M2 (8) IL-1RA Interleukin 1 receptor antagonist 3557 M2 (4) IL1RL1 Interleukin 1 receptor-like 1, ST2 9173 M2 (19) IL-2 3558 M1 (20) IL-21 59067 M2 (21) IL-21R Interleukin 21 receptor 50615 M2 (22) IL-23 , alpha; P19 51561 M1 (9) IL-27RA receptor, alpha 9466 M2 (13) IL2RA Interleukin 2 receptor, alpha 3559 M1 (2) IL-33 90865 M2 (19) IL-4 3565 M2 (3) IL-4RA Interleukin 4 receptor subunit alpha 3566 M2 (3) IL-6 (interferon, beta 2), HGF 3569 M1 (4) IL-7R receptor, CD127 3575 M1 (2) INDO Indoleamine 2,3-dioxygenase 1 3620 M1 (2) INHBA Inhibin, beta A 3624 M1 (2) iNOS Nitric oxide synthase 2, inducible; NOS2A 4843 M1 (8) IRF1 Interferon regulatory factor 1 3659 M1 (2) IRF4 Interferon regulatory factor 4 3662 M2 (23) IRF7 Interferon regulatory factor 7 3665 M1 (2) IRF8 Interferon regulatory factor 8 3394 M1 (24) LILRB4 Leukocyte immunoglobulin-like receptor, subfamily B, member 4 11006 Monocyte (2) LIPA Lipase A, lysosomal acid, cholesterol esterase 3988 M2 (2) LTA4H Leukotriene A4 4048 M2 (2) LYN V-yes-1 Yamaguchi sarcoma viral related oncogene homolog 4067 M2 (1) MAF v-Maf musculoaponeurotic fibrosarcoma oncogene homolog 4094 M2 (2) MAO-A Monoamine oxidase A 4128 M2 (3) MARCO Macrophage receptor with collagenous structure 8685 M1 (25) MMP12 Macrophage metalloelastase, matrix metallopeptidase 12 () 4321 M1 & M2 (26) MMP14 Matrix metallopeptidase 14 4323 M2 (1) MS4A4A Membrane-spanning 4-domains, subfamily A-member 4, CD20L1 51338 M2 (2) MS4A6A Membrane-spanning 4-domains, subfamily A, member 6A 64231 M2 (2) NFKBIA Nuclear factor of kappa polypeptide gene enhancer in B-cells inhibitor, alpha 4792 M2 (3) OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 4939 M1 (2) OASL 2'-5'-oligoadenylate synthetase-like 8638 M1 (2) ODC1 Ornithine decarboxylase 1 4953 M2 (27) OPN SPP1, Secreted phosphoprotein 1 6696 M1 (8) OTC Ornithine carbamoyltransferase 5009 M2 (5) P2RY14 Purinergic receptor P2Y, G-protein coupled, 14 9934 M2 (2) P2RY5 Purinergic receptor P2Y, G-protein coupled, 5 10161 M2 (2) P2X7R Purinergic receptor P2X, ligand-gated ion channel, 7 5027 M1 (3) PBEF1 Pre-B-cell colony enhancing factor 1 10135 M1 (2) PDGFA Platelet-derived growth factor alpha polypeptide 5154 M1 (2) PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 5209 M1 (2) PFKP Phosphofructokinase, platelet 5214 M1 (2) PGC-1a Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 10891 M2 (3) PGC-1b Peroxisome proliferator-activated receptor gamma, coactivator 1 beta 133522 M2 (3) PLA1A Phospholipase A1 member A 51365 M1 (2) PPAR-D Peroxisome proliferator-activated receptor delta, nuclear hormone receptor 1 5467 M2 (3) PPAR-G PPARG, peroxisome proliferator-activated receptor gamma 5468 M2 (3) PSMA2 Proteasome (prosome, macropain) subunit, alpha type, 2 5683 M1 (2) PSMB9 Proteasome (prosome, macropain) subunit, beta type, 9 5698 M1 (2) PSME2 Proteasome (prosome, macropain) activator subunit 2 5721 M1 (2) PTGS1 COX1, prostaglandin-endoperoxide synthase 1 and cyclooxygenase 5742 M2 (2) PTGS2 COX2, Prostaglandin-endoperoxide synthase 2 5743 M1 (2) PTX3 Pentraxin 3, long; TNFAIP5 5806 M1 (2) RANKL (ligand) superfamily, member 11, CD254 8600 M2 (13) SEPP1 Selenoprotein P, plasma, 1 6414 M2 (2) SHIP1 Inositol polyphosphate-5-phosphatase, 145kDa 3635 M2 (28) SHIP2 Inositol polyphosphate phosphatase-like 1 3636 M2 (28) SLC21A15 Solute carrier organic anion transporter family, member 5A1 81796 M1 (2) SLC21A9 Solute carrier organic anion transporter family, member 2B1 11309 M2 (2) SLC2A6 Solute carrier family 2 (facilitated transporter), member 6 11182 M1 (2) SLC31A2 Solute carrier family 31 (copper transporters), member 2 1318 M1 (2) SLC38A6 Solute carrier family 38, member 6 145389 M2 (2) SLC4A7 Solute carrier family 4, sodium bicarbonate cotransporter, member 7 9497 M2 (2) SLC7A5 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 8140 M1 (2) SOCS1 Suppressor of cytokine signaling 1 8651 M2 (3) SPARC Secreted protein, acidic, cysteine-rich (osteonectin) 6678 M2 (29) SPHK1 Sphingosine kinase 1 8877 M1 (2) SRA1 Steroid receptor RNA activator 1 10011 M2 (25) STAB1 Stabilin 1 23166 M2 (13) STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor) 6774 M2 (18) STAT6 Signal transducer and activator of transcription 6, interleukin-4 induced 6778 M2 (3) TGFBI Transforming growth factor, beta-induced, 68kDa 7045 M2 (9) TGFBR2 Transforming growth factor, beta receptor II (70/80kDa) 7048 M2 (9) TGIF2 TGFB-induced factor homeobox 2 60436 M2 (22) Tie2 TEK , endothelial, CD202B 7010 M2 (30) TLR1 Toll-like receptor 1 7096 M2 (9) TLR2 Toll-like receptor 2, CD282 7097 M1 (9) TLR3 Toll-like receptor 3 7098 M2 (9) TLR4 Toll-like receptor 4, CD284, 7099 M1 (9) TLR5 Toll-like receptor 5 7100 M2 (9) TLR6 Toll-like receptor 6 10333 M1 (31) TLR7 Toll-like receptor 7 51284 M1 (31) TLR8 Toll-like receptor 8 51311 M1 (32) TLR9 Toll-like receptor 9 54106 M1 (31) TNF-a Tumor necrosis factor (superfamily member 2), DIF 7124 M1 (7) TPST2 Tyrosylprotein sulfotransferase 2 8459 M2 (2) TRAIL Tumor necrosis factor (ligand) superfamily, member 10 8743 M1 (2) TREM2 Triggering receptor expressed on myeloid cells 2 54209 M2 (13) TRIM22 Tripartite motif-containing 22 10346 M1 (33) VEGF Vascular endothelial growth factor A 7422 M1 & M2 (7) Wnt-1 Wingless-type MMTV integration site family, member 1 7471 M2 (1) Wnt-10A Wingless-type MMTV integration site family, member 10A 80326 M2 (1) Wnt-16 Wingless-type MMTV integration site family, member 16 51384 M2 (1) Wnt-3 Wingless-type MMTV integration site family, member 3 7473 M2 (1) Wnt-4 Wingless-type MMTV integration site family, member 4 54361 M2 (1, 22) Wnt-5a Wingless-type MMTV integration site family, member 5A 7474 M2 (1) Wnt-5b Wingless-type MMTV integration site family, member 5B 81029 M2 (1) Wnt-6 Wingless-type MMTV integration site family, member 6 7475 M2 (1) Wnt-7b Wingless-type MMTV integration site family, member 7B 7477 M2 (1) Wnt-9a Wingless-type MMTV integration site family, member 9A 7483 M2 (1) Wnt-9b Wingless-type MMTV integration site family, member 9B 7484 M2 (1) ZAP70 Zeta-chain (TCR) associated protein kinase 70kDa 7535 ↓T cells if M2 (20)

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