DOCSLIB.ORG

2021 Essential Asthma Drug List

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2021 Essential Asthma Drug List 2021 Essential Asthma Drug List Label Drug Name Generic Drug Name Formulary Status ACCOLATE TAB 10MG ZAFIRLUKAST Formulary ACCOLATE TAB 20MG ZAFIRLUKAST Formulary ADVAIR DISKU AER 100/50 FLUTICASONE PROPION/SALMETEROL Formulary ADVAIR DISKU AER 250/50 FLUTICASONE PROPION/SALMETEROL Formulary ADVAIR DISKU AER 500/50 FLUTICASONE PROPION/SALMETEROL Formulary ADVAIR HFA AER 45/21 FLUTICASONE PROPION/SALMETEROL Formulary ADVAIR HFA AER 115/21 FLUTICASONE PROPION/SALMETEROL Formulary ADVAIR HFA AER 230/21 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO DGHLR INH 113-14 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO DGHLR INH 232-14 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO DGHLR INH 55-14 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO RESPI INH 113-14 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO RESPI INH 232-14 FLUTICASONE PROPION/SALMETEROL Formulary AIRDUO RESPI INH 55-14 FLUTICASONE PROPION/SALMETEROL Formulary ALBUTEROL TAB 2MG ALBUTEROL SULFATE Formulary ALBUTEROL TAB 4MG ALBUTEROL SULFATE Formulary ALBUTEROL SYP 2MG/5ML ALBUTEROL SULFATE Formulary ALBUTEROL NEB 0.083% ALBUTEROL SULFATE Formulary ALBUTEROL NEB 0.5% ALBUTEROL SULFATE Formulary ALBUTEROL NEB 0.63MG/3 ALBUTEROL SULFATE Formulary ALBUTEROL NEB 1.25MG/3 ALBUTEROL SULFATE Formulary ALBUTEROL TAB 4MG ER ALBUTEROL SULFATE Formulary ALBUTEROL TAB 8MG ER ALBUTEROL SULFATE Formulary ALBUTEROL AER HFA ALBUTEROL SULFATE Formulary ALBUTEROL AER HFA ALBUTEROL SULFATE Non-Formulary ALVESCO AER 80MCG CICLESONIDE Formulary ALVESCO AER 160MCG CICLESONIDE Formulary AMINOPHYLLIN INJ 25MG/ML AMINOPHYLLINE Non-Formulary ARMONAIR AER 113/ACT FLUTICASONE PROPIONATE Formulary ARMONAIR AER 232/ACT FLUTICASONE PROPIONATE Formulary ARMONAIR AER 55/ACT FLUTICASONE PROPIONATE Formulary ARNUITY ELPT INH 100MCG FLUTICASONE FUROATE Formulary ARNUITY ELPT INH 200MCG FLUTICASONE FUROATE Formulary ARNUITY ELPT INH 50MCG FLUTICASONE FUROATE Formulary ASMANEX 120 AER 220MCG MOMETASONE FUROATE Formulary ASMANEX 60 AER 220MCG MOMETASONE FUROATE Formulary ASMANEX 14 AER 220MCG MOMETASONE FUROATE Formulary ASMANEX 30 AER 220MCG MOMETASONE FUROATE Formulary ASMANEX 30 AER 110MCG MOMETASONE FUROATE Formulary ASMANEX 7 AER 110MCG MOMETASONE FUROATE Formulary ASMANEX HFA AER 100 MCG MOMETASONE FUROATE Formulary ASMANEX HFA AER 200 MCG MOMETASONE FUROATE Formulary ASMANEX HFA AER 50MCG MOMETASONE FUROATE Formulary ASTHMANEFRIN NEB 2.25% RACEPINEPHRINE HCL Non-Formulary Page 1 of 4 ATROVENT HFA AER 17MCG IPRATROPIUM BROMIDE Formulary BREO ELLIPTA INH 200-25 FLUTICASONE/VILANTEROL Formulary BREO ELLIPTA INH 100-25 FLUTICASONE/VILANTEROL Formulary BRONKAID TAB 25-400MG EPHEDRINE SULFATE/GUAIFENESIN Non-Formulary BUDESONIDE SUS 0.25MG/2 BUDESONIDE Formulary BUDESONIDE SUS 0.5MG/2 BUDESONIDE Formulary BUDESONIDE SUS 1MG/2ML BUDESONIDE Formulary BUDES/FORMOT AER 160-4.5 BUDESONIDE/FORMOTEROL FUMARATE Non-Formulary BUDES/FORMOT AER 80-4.5 BUDESONIDE/FORMOTEROL FUMARATE Non-Formulary CINQAIR INJ RESLIZUMAB Non-Formulary COMBIVENT AER 20-100 IPRATROPIUM/ALBUTEROL SULFATE Formulary CROMOLYN SOD NEB 20MG/2ML CROMOLYN SODIUM Formulary CROMOLYN SOD SPR 5.2/ACT CROMOLYN SODIUM Non-Formulary DUAKLIR AER 400/12 ACLIDINIUM BROM/FORMOTEROL FUM Formulary DULERA AER 200-5MCG MOMETASONE/FORMOTEROL Formulary DULERA AER 100-5MCG MOMETASONE/FORMOTEROL Formulary DULERA AER 50-5MCG MOMETASONE/FORMOTEROL Formulary ELIXOPHYLLIN ELX 80/15ML THEOPHYLLINE ANHYDROUS Formulary FASENRA INJ 30MG/ML BENRALIZUMAB Non-Formulary FASENRA PEN INJ 30MG/ML BENRALIZUMAB Formulary FLOVENT DISK AER 50MCG FLUTICASONE PROPIONATE Formulary FLOVENT DISK AER 250MCG FLUTICASONE PROPIONATE Formulary FLOVENT DISK AER 100MCG FLUTICASONE PROPIONATE Formulary FLOVENT HFA AER 44MCG FLUTICASONE PROPIONATE Formulary FLOVENT HFA AER 110MCG FLUTICASONE PROPIONATE Formulary FLOVENT HFA AER 220MCG FLUTICASONE PROPIONATE Formulary FLUTIC/SALME INH 55/14 FLUTICASONE PROPION/SALMETEROL Formulary FLUTIC/SALME INH 113/14 FLUTICASONE PROPION/SALMETEROL Formulary FLUTIC/SALME INH 232/14 FLUTICASONE PROPION/SALMETEROL Formulary FLUTIC/SALME AER 100/50 FLUTICASONE PROPION/SALMETEROL Formulary FLUTIC/SALME AER 250/50 FLUTICASONE PROPION/SALMETEROL Formulary FLUTIC/SALME AER 500/50 FLUTICASONE PROPION/SALMETEROL Formulary IPRATROPIUM SOL 0.02%INH IPRATROPIUM BROMIDE Formulary IPRATROPIUM/ SOL ALBUTER IPRATROPIUM/ALBUTEROL SULFATE Formulary LEVALBUTEROL NEB 1.25/0.5 LEVALBUTEROL HCL Formulary LEVALBUTEROL NEB 0.31MG LEVALBUTEROL HCL Formulary LEVALBUTEROL NEB 0.63MG LEVALBUTEROL HCL Formulary LEVALBUTEROL NEB 1.25MG LEVALBUTEROL HCL Formulary LEVALBUTEROL AER 45/ACT LEVALBUTEROL TARTRATE Non-Formulary METAPROTEREN SYP 10MG/5ML METAPROTERENOL SULFATE Formulary METAPROTEREN TAB 10MG METAPROTERENOL SULFATE Formulary METAPROTEREN TAB 20MG METAPROTERENOL SULFATE Formulary MONTELUKAST CHW 4MG MONTELUKAST SODIUM Formulary MONTELUKAST CHW 5MG MONTELUKAST SODIUM Formulary MONTELUKAST TAB 10MG MONTELUKAST SODIUM Formulary MONTELUKAST GRA 4MG MONTELUKAST SODIUM Formulary NASALCROM SPR 5.2/ACT CROMOLYN SODIUM Non-Formulary Page 2 of 4 NUCALA INJ 100MG MEPOLIZUMAB Medical Benefit NUCALA INJ 100MG/ML MEPOLIZUMAB Formulary PRIMATENE AER 0.125MG EPINEPHRINE Non-Formulary PROAIR DIGIH AER 108MCG ALBUTEROL SULFATE Formulary PROAIR HFA AER ALBUTEROL SULFATE Formulary PROAIR RESPI AER ALBUTEROL SULFATE Formulary PROVENTIL AER HFA ALBUTEROL SULFATE Non-Formulary PULMICORT SUS 0.25MG/2 BUDESONIDE Non-Formulary PULMICORT SUS 0.5MG/2 BUDESONIDE Non-Formulary PULMICORT SUS 1MG/2ML BUDESONIDE Non-Formulary PULMICORT INH 180MCG BUDESONIDE Formulary PULMICORT INH 90MCG BUDESONIDE Formulary QVAR REDIHAL AER 40MCG BECLOMETHASONE DIPROPIONATE Formulary QVAR REDIHA AER 80MCG BECLOMETHASONE DIPROPIONATE Formulary S2 NEB 2.25% RACEPINEPHRINE HCL Non-Formulary SEEBRI NEOHA CAP 15.6MCG GLYCOPYRROLATE Formulary SEREVENT DIS AER 50MCG SALMETEROL XINAFOATE Formulary SINGULAIR GRA 4MG MONTELUKAST SODIUM Non-Formulary SINGULAIR CHW 4MG MONTELUKAST SODIUM Non-Formulary SINGULAIR TAB 10MG MONTELUKAST SODIUM Non-Formulary SINGULAIR CHW 5MG MONTELUKAST SODIUM Non-Formulary SPIRIVA CAP HANDIHLR TIOTROPIUM BROMIDE Formulary SPIRIVA AER 1.25MCG TIOTROPIUM BROMIDE Formulary SYMBICORT AER 160-4.5 BUDESONIDE/FORMOTEROL FUMARATE Formulary SYMBICORT AER 80-4.5 BUDESONIDE/FORMOTEROL FUMARATE Formulary TERBUTALINE TAB 2.5MG TERBUTALINE SULFATE Formulary TERBUTALINE TAB 5MG TERBUTALINE SULFATE Formulary TERBUTALINE INJ 1MG/ML TERBUTALINE SULFATE Formulary THEO-24 CAP 100MG CR THEOPHYLLINE ANHYDROUS Formulary THEO-24 CAP 200MG CR THEOPHYLLINE ANHYDROUS Formulary THEO-24 CAP 300MG CR THEOPHYLLINE ANHYDROUS Formulary THEO-24 CAP 400MG ER THEOPHYLLINE ANHYDROUS Formulary THEOCHRON TAB 100MG CR THEOPHYLLINE ANHYDROUS Formulary THEOCHRON TAB 200MG CR THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE SOL 80/15ML THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 200MG CR THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 100MG CR THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 450MG ER THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 300MG ER THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 400MG ER THEOPHYLLINE ANHYDROUS Formulary THEOPHYLLINE TAB 600MG ER THEOPHYLLINE ANHYDROUS Formulary UTIBRON CAP NEOHALER INDACATEROL/GLYCOPYRROLATE Formulary VENTOLIN HFA AER ALBUTEROL SULFATE Formulary WIXELA INHUB AER 100/50 FLUTICASONE PROPION/SALMETEROL Formulary WIXELA INHUB AER 250/50 FLUTICASONE PROPION/SALMETEROL Formulary WIXELA INHUB AER 500/50 FLUTICASONE PROPION/SALMETEROL Formulary XOLAIR INJ 75/0.5 OMALIZUMAB Medical Benefit Page 3 of 4 XOLAIR INJ 150MG/ML OMALIZUMAB Medical Benefit XOLAIR SOL 150MG OMALIZUMAB Medical Benefit XOPENEX NEB 0.31MG LEVALBUTEROL HCL Formulary XOPENEX NEB 0.63MG LEVALBUTEROL HCL Formulary XOPENEX NEB 1.25/3ML LEVALBUTEROL HCL Formulary XOPENEX CONC NEB 1.25/0.5 LEVALBUTEROL HCL Formulary XOPENEX HFA AER LEVALBUTEROL TARTRATE Non-Formulary YUPELRI SOL REVEFENACIN Formulary ZAFIRLUKAST TAB 20MG ZAFIRLUKAST Formulary ZAFIRLUKAST TAB 10MG ZAFIRLUKAST Formulary ZILEUTON ER TAB 600MG ZILEUTON Formulary ZYFLO TAB 600MG ZILEUTON Formulary ZYFLO CR TAB 600MG ZILEUTON Formulary Page 4 of 4.
Load more

Recommended publications
  • Inhibitory Activity of Pranlukast and Montelukas Against Histamine
    Showa Univ J Med Sci 21（2）, 77～84, June 2009 Original Inhibitory Activity of Pranlukast and Montelukas Against Histamine Release and LTC4 Production from Human Basophils 1, 2 1 1 Satoshi HIBINO ）, Ryoko ITO ）, Taeru KITABAYASHI ）, 1 2 Kazuo ITAHASHI ） and Toshio NAKADATE ） Abstract : Leukotriene receptor antagonists（LTRAs）are routinely used to treat bronchial asthma and are thought to act mostly by inhibiting leukotriene receptors. However, there is no preclinical or clinical evidence of the direct effect of LTRAs on histamine release from and leukotriene（LT）C4 produc- tion by basophils. We used anti-IgE antibody（Ab）, FMLP, and C5a to induce histamine release, and anti-IgE Ab and FMLP to stimulate LTC 4 production. Basophils were exposed to different concentrations of pranlukast and montelu- kast, and then to anti-IgE Ab, FMLP, and C5a. Culture supernatant histamine and LTC 4 levels were measured by using a histamine ELISA kit and a LTC 4 EIA kit, respectively. Histamine release was expressed as a percentage of the total histamine content（％HR）induced by anti-IgE Ab, FMLP, or C5a. To evaluate the effects of pranlukast and montelukast on histamine release and LTC 4 production, we calculated the percent inhibition of histamine release and LTC 4 production, expressed as percent inhibition, at different concentrations of pranlukast and montelukast. Pranlukast significantly inhibited histamine release stimulated by FMLP and C5a, but had no effect on histamine release stimulated by anti-IgE Ab. By comparison, montelukast signicantly inhibited histamine release stimulated by FMLP, C5a, and anti-IgE Ab, in a concentration-dependent manner. Both pranlukast and montelukast signicantly inhibited LTC 4 production stimulated by anti-IgE Ab and FMLP.
    [Show full text]
  • Montelukast Sodium) Tablets, Chewable Tablets, and Oral
    Merck Sharp & Dohme Corp., a subsidiary of o MERCK & CO., INC. Whitehouse Station, NJ 08889/ USA HIGHLIGHTS OF PRESCRIBING INFORMATION .....................DOSAGE FORMS AND STRENGTHS..................... These highlights do not include all the information needed to use . SINGULAIR 10-mg Film-Coated Tablets SINGULAIR safely and effectively. See full prescribing information . SINGULAIR 5-mg and 4-mg Chewable Tablets for SINGULAIR. SINGULAIR 4.mg Oral Granules SINGULAIRiI .............................. CONTRAINDICATIONS .............................. (montelukast sodium) tablets, chewable tablets, and oral . Hypersensitivity to any component of this product (4). granules ....................... WARNINGS AND PRECAUTIONS ....................... Initial U.S. Approval: 1998 . Do not prescribe SINGULAIR to treat an acute asthma attack. .......................... RECENT MAJOR CHANGES........................... Advise patients to have appropriate rescue medication available Warnings and Precautions, Neuropsychiatric Events (5.4) 04/2010 (5.1). Inhaled corticosteroid may be reduced gradually. Do not abruptly ...........................INDICATIONS AND USAGE ........................... substitute SINGULAIR for inhaled or oral corticosteroids (5.2). SINGULAIRiI is a leukotriene receptor antagonist indicated for: . Patients with known aspirin sensitivity should continue to avoid . Prophylaxis and chronic treatment of asthma in patients aspirin or non-steroidal anti-inflammatory agents while taking 12 months of age and older (1.1). SINGULAIR (5.3). Acute prevention of exercise-induced bronchoconstriction (EIS) in Neuropsychiatric events have been reported with SINGULAIR. patients 15 years of age and older (1.2). Instruct patients to be alert for neuropsychiatric events. Evaluate Relief of symptoms of allergic rhinitis (AR): seasonal allergic the risks and benefits of continuing treatment with SINGULAIR if rhinitis (SAR) in patients 2 years of age and older, and perennial such events occur (5.4 and 6.2).
    [Show full text]
  • FDA Briefing Document Pulmonary-Allergy Drugs Advisory Committee Meeting
    FDA Briefing Document Pulmonary-Allergy Drugs Advisory Committee Meeting August 31, 2020 sNDA 209482: fluticasone furoate/umeclidinium/vilanterol fixed dose combination to reduce all-cause mortality in patients with chronic obstructive pulmonary disease NDA209482/S-0008 PADAC Clinical and Statistical Briefing Document Fluticasone furoate/umeclidinium/vilanterol fixed dose combination for all-cause mortality DISCLAIMER STATEMENT The attached package contains background information prepared by the Food and Drug Administration (FDA) for the panel members of the advisory committee. The FDA background package often contains assessments and/or conclusions and recommendations written by individual FDA reviewers. Such conclusions and recommendations do not necessarily represent the final position of the individual reviewers, nor do they necessarily represent the final position of the Review Division or Office. We have brought the supplemental New Drug Application (sNDA) 209482, for fluticasone furoate/umeclidinium/vilanterol, as an inhaled fixed dose combination, for the reduction in all-cause mortality in patients with COPD, to this Advisory Committee in order to gain the Committee’s insights and opinions, and the background package may not include all issues relevant to the final regulatory recommendation and instead is intended to focus on issues identified by the Agency for discussion by the advisory committee. The FDA will not issue a final determination on the issues at hand until input from the advisory committee process has been considered
    [Show full text]
  • Singulair (Montelukast Sodium)
    HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use --------------------- DOSAGE FORMS AND STRENGTHS --------------------­ SINGULAIR safely and effectively. See full prescribing information SINGULAIR 10-mg Film-Coated Tablets for SINGULAIR. SINGULAIR 5-mg and 4-mg Chewable Tablets SINGULAIR 4-mg Oral Granules (3) SINGULAIR® (montelukast sodium) Tablets, Chewable Tablets, -------------------------------CONTRAINDICATIONS ------------------------------­ and Oral Granules Hypersensitivity to any component of this product (4). Initial U.S. Approval: 1998 ------------------------WARNINGS AND PRECAUTIONS-----------------------­ ---------------------------RECENT MAJOR CHANGES --------------------------­ Do not prescribe SINGULAIR to treat an acute asthma attack Indications and Usage (5.1). Exercise-Induced Bronchoconstriction (EIB) (1.2) 03/2012 Dosage and Administration Advise patients to have appropriate rescue medication available Exercise-Induced Bronchoconstriction (EIB) (2.2) 03/2012 (5.1). Inhaled corticosteroid may be reduced gradually. Do not abruptly ----------------------------INDICATIONS AND USAGE ---------------------------­ substitute SINGULAIR for inhaled or oral corticosteroids (5.2). SINGULAIR is a leukotriene receptor antagonist indicated for: Patients with known aspirin sensitivity should continue to avoid Prophylaxis and chronic treatment of asthma in patients aspirin or non-steroidal anti-inflammatory agents while taking 12 months of age and older (1.1). SINGULAIR (5.3). Acute prevention of exercise-induced bronchoconstriction (EIB) in Neuropsychiatric events have been reported with SINGULAIR. patients 6 years of age and older (1.2). Instruct patients to be alert for neuropsychiatric events. Evaluate Relief of symptoms of allergic rhinitis (AR): seasonal allergic the risks and benefits of continuing treatment with SINGULAIR if rhinitis (SAR) in patients 2 years of age and older, and perennial such events occur (5.4 and 6.2).
    [Show full text]
  • Montelukast and Neuropsychiatric Events in Children with Asthma: a Nested Case-Control Study
    ORIGINAL ARTICLES Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case–Control Study S. Dresden Glockler-Lauf, MPH1, Yaron Finkelstein, MD1,2,3,4,5, Jingqin Zhu, MSc1,2, Laura Y. Feldman, MPH1, and Teresa To, PhD1,2,6 Objective To examine the association between montelukast prescription and neuropsychiatric events in children with asthma. Study design A matched, nested case–control design was used to identify cases and controls from a cohort of children aged 5-18 years with physician-diagnosed asthma from 2004 to 2015, in Ontario, Canada, prescribed an asthma maintenance medication. Cases were children with a hospitalization or emergency department visit for a neuropsychiatric event. Cases were matched to up to 4 controls on birth year, year of asthma diagnosis, and sex. The exposures were dispensed prescriptions for montelukast (yes/no) and number of dispensed montelukast prescriptions in the year before the index date. Conditional logistic regression was used to measure the unadjusted OR and aOR and 95% CIs for montelukast prescription and neuropsychiatric events. Covariates in the adjusted model included sociodemographic factors and measures of asthma severity. Results In total, 898 cases with a neuropsychiatric event and 3497 matched controls were included. Children who experienced a new-onset neuropsychiatric event had nearly 2 times the odds of having been prescribed montelu- kast, compared with controls (OR 1.91, 95% CI 1.15-3.18; P = .01). Most cases presented for anxiety (48.6%) and/ or sleep disturbance (26.1%). Conclusions Children with asthma who experienced a new-onset neuropsychiatric event had nearly twice the odds of having been prescribed montelukast in the year before their event.
    [Show full text]
  • Monteleucast and Zileuton Retard the Progression of Atherosclerosis Via Down Regulation of the Inflammatory and Oxidative Pathwa
    & Experim l e ca n i t in a l l C C f a Journal of Clinical & Experimental Hadi et al., J Clin Exp Cardiolog 2013, 4:6 o r d l i a o DOI: 10.4172/2155-9880.1000250 n l o r g u y o J Cardiology ISSN: 2155-9880 Research Article Open Access Monteleucast and Zileuton Retard the Progression of Atherosclerosis via Down Regulation of the Inflammatory and Oxidative Pathways Najah R Hadi1*, Bassim I Mohammad2, Ahmad Almudhafer1, Naser Yousif3 and Ahmed M Sultan2 1Kufa College of Medicine, Iraq 2Al-Qadesiyah University, Iraq 3Colorado University, USA Abstract Background: Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. Leukotrines are involved in different stages of atherosclerosis. Therefore this study was undertaken to evaluate the effect of montelukast and zileuton on the progression of atherosclerosis. Materials and methods: Thirty-five male rabbits were used in this study. These animals randomized into 5 groups (7 rabbits each). Rabbits in first group were maintained on normal rabbit chow diet and used as normal diet control group (NC). While the rabbits in other four groups were fed on atherogenic diet (2% cholesterol) for 8 weeks. The second group, Atherogenic Control Group (AC) rabbits received atherogenic diet alone. Third group, Positive Control Group (PC) rabbits received atherogenic diet and ethanol as vehicle. Forth group, Montelukast Treated Group (MT) rabbits received montelukast 1.5 mg per kg daily and the fifth group, Zileuton Treated Group (ZT) rabbits received zileuton 150 mg per kg daily. At the end of 8th weeks animals were sacrificed, blood sample was collected to measure the following parameters: lipid profile, plasma GSH, MDA, and hsCRP.
    [Show full text]
  • Leukotriene Modifiers (Accolate®, Singulair®, Zileuton®)
    Leukotriene Modifiers (Accolate®, Singulair®, Zileuton®) What are They? Leukotriene modifiers reduce swelling and inflammation in the airways to prevent asthma symptoms. You may not notice a change in your asthma symptoms for one to two week, after starting to use them. • These medicines will not stop a sudden asthma attack. Albuterol should be used for sudden asthma attacks. • Only regular daily use of the leukotriene modifiers will prevent asthma symptoms. • It is important that you do not stop or decrease the dose of these medications without contacting your doctor. How should they be used? • Zafirlukast (Accolate®) is a tablet that is taken by mouth twice a day on an empty stomach (1 hour before you eat or 2 hours after you eat). It is very important to take this medicine on an empty stomach. o Zafirlukast must be taken every day even if you don’t have asthma symptoms. If you forget to take your dose on time, do not take twice as much the next time. Take the regularly scheduled dose as soon as you remember, then get back to your regular schedule. o Side effects . Zafirlukast (Accolate®) causes very few side effects. Some people may have headaches, nausea, or diarrhea. Although these side effects are quite uncommon, it is important for you to let your doctor know if you are experiencing any of these while taking zafirlukast. • Montelukast (Singulair®) o A tablet that is taken once a day at nighttime. o You can take Montelukast with or without food. o Montelukast must be taken every day even if you don’t have asthma symptoms.
    [Show full text]
  • Inflammation, Cancer and Oxidative Lipoxygenase Activity Are Intimately Linked
    Cancers 2014, 6, 1500-1521; doi:10.3390/cancers6031500 OPEN ACCESS cancers ISSN 2072-6694 www.mdpi.com/journal/cancers Review Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked Rosalina Wisastra and Frank J. Dekker * Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +31-5-3638030; Fax: +31-5-3637953. Received: 16 April 2014; in revised form: 27 June 2014 / Accepted: 2 July 2014 / Published: 17 July 2014 Abstract: Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved in arachidonic acid metabolism. An increasing number of arachidonic acid metabolites is being discovered and apart from their classically recognized pro-inflammatory effects, anti-inflammatory effects are also being described in recent years. Interestingly, these lipid mediators are involved in activation of pro-inflammatory signal transduction pathways such as the nuclear factor κB (NF-κB) pathway, which illustrates the intimate link between lipid signaling and transcription factor activation. The identification of the role of arachidonic acid metabolites in several inflammatory diseases led to a significant drug discovery effort around arachidonic acid metabolizing enzymes. However, to date success in this area has been limited. This might be attributed to the lack of selectivity of the developed inhibitors and to a lack of detailed understanding of the functional roles of arachidonic acid metabolites in inflammatory responses and cancer.
    [Show full text]
  • Bnf Chapter 3: Respiratory
    BNF CHAPTER 3: RESPIRATORY Information resources: ● If an inhaler device is changed then patients must be assessed to ensure inhaler technique is adequate Respiratory Futures Consider issuing a Steroid warning card to patients prescribed high dose inhaled steroids Asthma guidelines NICE guideline [NG80] Asthma: diagnosis, monitoring and chronic asthma management NICE guidance TA 138 Asthma - inhaled corticosteroids for the treatment of chronic asthma in adults and children aged 12 years and over. https://www.sign.ac.uk/assets/sign153.pdf SIGN 153: British guideline on the management of asthma Global Initiative for Asthma 2018. GINA Report, Global Strategy for Asthma Management and Prevention. West Cheshire local guidelines COPD guidelines: NICE [NG115] COPD in over 16s diagnosis and management. NICE guideline Dec 18 [NG115] GOLD : Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Pulmonary Disease 2018 Report West Cheshire local guidelines Abbreviations used: MDI: metered dose inhaler DPI: dry powder inhaler SABA: short acting beta agonist LABA: long acting beta agonist SAMA: short acting muscarinic antagonist LAMA: long acting muscarinic antagonist ICS: inhaled corticosteroid LTRA: leukotriene receptor antagonist PDE4: phosphodiesterase-4 enzyme inhibitor Joint Formulary – Respiratory Approved by Area Prescribing Committee: n/a Review by: July 2021 3.1 BRONCHODILATORS 3.1.1.1 SELECTIVE BETA2-AGONISTS Short acting Beta2 Agonist (SABA) Salbutamol 100 micrograms/metered inhalation MDI 100/200
    [Show full text]
  • Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonist
    Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonists This information is current as of September 27, 2021. Grzegorz Woszczek, Li-Yuan Chen, Sara Alsaaty, Sahrudaya Nagineni and James H. Shelhamer J Immunol 2010; 184:2219-2225; Prepublished online 18 January 2010; doi: 10.4049/jimmunol.0900071 Downloaded from http://www.jimmunol.org/content/184/4/2219 References This article cites 38 articles, 10 of which you can access for free at: http://www.jimmunol.org/ http://www.jimmunol.org/content/184/4/2219.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists by guest on September 27, 2021 • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2010 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Concentration-Dependent Noncysteinyl Leukotriene Type 1 Receptor-Mediated Inhibitory Activity of Leukotriene Receptor Antagonists Grzegorz Woszczek,*,†,1 Li-Yuan Chen,*,1 Sara Alsaaty,* Sahrudaya Nagineni,* and James H. Shelhamer* The use of cysteinyl leukotriene receptor antagonists (LTRAs) for asthma therapy has been associated with a significant degree of interpatient variability in response to treatment.
    [Show full text]
  • Montelukast in Acute Asthma Attack
    Osmangazi Tıp Dergisi Araştırma Makalesi Osmangazi Journal of Medicine Research Article The Effects of Montelukast in Children Between 6-16 Years with Moderate-Severe Acute Asthma Attack Orta-Ağır Akut Astım Atağı ile Başvuran 6-16 Yaş arası Çocuklarda Montelukastın Etkinliğinin Belirlenmesi 1Beyhan Küçükbayrak, 2Koray Harmancı, 3Gülşen Köse, 2Hülya Anıl 1Clinic of Pediatrics, Izzet State Hospital, Bolu, Turkey 2Pediatric Allergy and Immunology Department, Osmangazi University Medical Faculty, Eskisehir, Turkey 3Neurology Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey Abstract: The aim of this study is to evaluate the effect to respiratory parameters (retraction, asthma attack score- AAS, positive expiratory flow rate- PEFR-, dispnea parameters, auscultation) of montelukast in children aged between 6-16 years admitted with moderate or severe acute asthma attacks. In this study, thirty children presented with moderate or severe asthma attack were evaluated. The study is a randomized, double blind, placebo-controlled parallel trial. The patients were randomly divided into two groups. All patients were given nebulized salbutamol (0.15 mg/kg), ipratropium bromide (250 mcg/doz), 1 mg/kg of oral methyl prednisolone and O2 as initial treatment. In addition to these medications, the placebo of montelukast 5 mg was given orally in the Group I, and montelukast 5 mg drug was given orally to the patients in the Group II. Then, additional 0.15 mg/kg nebulized Salbutamol and 250 mcg/dosage Ipratropium bromides were given twice with 20 minute interval. Besides, the patients were evaluated at 0., 20., 40., 60., 90., 120., 180., and 240. minutes for the criteria of therapeutic response such as respiratory parameters.
    [Show full text]
  • Antileukotrienes in Upper Airway Inflammatory Diseases
    Curr Allergy Asthma Rep (2015) 15:64 DOI 10.1007/s11882-015-0564-7 RHINOSINUSITIS (J MULLOL, SECTION EDITOR) Antileukotrienes in Upper Airway Inflammatory Diseases Cemal Cingi1,5 & Nuray Bayar Muluk2 & Kagan Ipci3 & Ethem Şahin4 # Springer Science+Business Media New York 2015 Abstract Leukotrienes (LTs) are a family of inflammatory zileuton, ZD2138, Bay X 1005, and MK-0591). CysLTs have mediators including LTA4,LTB4,LTC4,LTD4, and LTE4. important proinflammatory and profibrotic effects that con- By competitive binding to the cysteinyl LT1 (CysLT1)recep- tribute to the extensive hyperplastic rhinosinusitis and nasal tor, LT receptor antagonist drugs, such as montelukast, polyposis (NP) that characterise these disorders. Patients who zafirlukast, and pranlukast, block the effects of CysLTs, im- receive zafirlukast or zileuton tend to show objective improve- proving the symptoms of some chronic respiratory diseases, ments in, or at least stabilisation of, NP.Montelukast treatment particularly bronchial asthma and allergic rhinitis. We may lead to clinical subjective improvement in NP. reviewed the efficacy of antileukotrienes in upper airway in- Montelukast treatment after sinus surgery can lead to a signif- flammatory diseases. An update on the use of antileukotrienes icant reduction in eosinophilic cationic protein levels in se- in upper airway diseases in children and adults is presented rum, with a beneficial effect on nasal and pulmonary symp- with a detailed literature survey. Data on LTs, antileukotrienes, toms and less impact in NP. Combined inhaled corticosteroids and antileukotrienes in chronic rhinosinusitis and nasal and long-acting β-agonists treatments are most effective for polyps, asthma, and allergic rhinitis are presented. preventing exacerbations among paediatric asthma patients.
    [Show full text]