Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_005166365Cyc: Enterococcus faecium NM213 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a basic uracil a pyrimidine an a nicotinamide phosphonate N-acetyl-α-D- an inorganic lactose lactose lactose a sugar a sugar (RS)-malate galactitol ferrichrome trehalose amino acid sucrose D-glucose a nucleotide lactose a siderophore D-cellobiose D-cellobiose nucleoside oligopeptide mononucleotide phosphite glucosamine anion D-cellobiose D-cellobiose D-cellobiose

an (aminoalkyl)phosphonate cis-vaccenate an alkylphosphonate a 2,3,4-saturated fatty acid predicted PEP-driven RS03255 RS03405 RS01290 RS02375 RS03585 RS09740 RS07175 RS01765 RS05260 RS09560 RS00050 RS00055 RS12900 RS08250 RS10735 RS07780 RS13615 RS04935 RS00820 RS09690 RS03490 RS01800 transporter RS08865 RS14135 RS00815 of D- cellobiose uracil a sugar 6- a sugar 6- a pyrimidine an a nicotinamide galactitol 1- D-trehalose phosphonate an (aminoalkyl)phosphonate sucrose 6 G N-acetyl-α-D- an inorganic lactose 6'- cis-vaccenoyl-CoA D-cellobiose lactose 6'-phosphate lactose 6'-phosphate lactose 6'-phosphate (RS)-malate ferrichrome a basic D-glucose a nucleotide a siderophore phosphate phosphate nucleoside oligopeptide mononucleotide phosphate 6-phosphate phosphite an alkylphosphonate -phosphate glucosamine anion phosphate a 2,3,4-saturated fatty acyl CoA 6'- D-cellobiose 6'-phosphate D-cellobiose 6'-phosphate D-cellobiose 6'-phosphate amino acid 6-phosphate phosphate D-cellobiose 6'- phosphate

Macromolecule Modification Secondary Metabolite Biosynthesis Carbohydrate Degradation Metabolic Regulator C1 Compound Utilization Nucleoside and Nucleotide Biosynthesis an inactive an sn-glycero-3- a glycopeptide- sn-glycero-3- a ribonucleoside 5'-chloro-5'- a (3R)-3- a (3R)-3- a (3R,6Z)-3- DNA combined superpathway of pyrimidine Biosynthesis tRNA processing and Assimilation a (6S)-5- γ-L-glutamyl-(S)- DHAP UMP biosynthesis III superpathway of guanosine superpathway of pyrimidine ribonucleosides salvage adenine salvage ribonucleoside a reduced phospho-N-(acyl) D-mannosyl-N 4 phospho-N- glycerophosphoserine glu 2',3'-cyclic gly hydroxyhexacosanoyl- hydroxydocosanoyl- hydroxyoctadec- with exogenous deoxyribonucleotides de novo biosynthesis autoinducer AI-2 biosynthesis I D-galactose degradation I (Leloir pathway) D-galactose degradation V (Leloir pathway) SAM deoxyadenosine nucleotides de novo biosynthesis I formyltetrahydrofolate 2-aminobutanoate ppGpp biosynthesis formate assimilation into 5,10- triphosphate flavodoxin ethanolamine -(N-acetyl-D- (arachidonoyl) glycerophosphoryl phosphate purine-nucleoside NAD(P)H- [acp] 3-hydroxyacyl- [acp] 3-hydroxyacyl- 6-enoyl-[acp]3-hydroxyacyl- DNA to form a a polycistronic glycerophosphoryl bifunctional multifunctional 2',3'- bifunctional cytidine reductase anaerobic glucosaminyl) ethanolamineglycerophosphodiester diester phosphorylase: dependent glycerol- recombinational β β-D-galactopyranose methylenetetrahydrofolate diester folylpolyglutamate cyclic-nucleotide 2'- glutamate- ACP ACP ACP Holliday gln hydrogencarbonate gln hydrogencarbonate adenine SAM tRNA precursor -D-galactopyranose ribonucleoside- mannosyl-glycoprotein -asparagine phosphodiesterase: phosphodiesterase: deoD 3-phosphate dehydratase dehydratase dehydratase junction IMP pppGpp phosphodiesterase: 2 endo-beta-N- synthase/ phosphodiesterase/ -cysteine junction cytidine deaminase: galactose formate triphosphate EO217_RS13340 EO217_RS05330 dehydrogenase: galactose EO217_RS05330 dihydrofolate 5'-nucleotidase/ purine-nucleoside ligase GshA/ FabZ: fabZ FabZ: fabZ FabZ: fabZ resolvase carbamoyl-phosphate EO217_RS10080 reductase acetylglucosamidase: bifunctional (p)ppGpp mutarotase: mutarotase: formate-- glycerophosphodiester phosphorylase: EO217_RS12880 nitrite nitrite carbamoyl-phosphate synthase large IMP glycerophosphodiester EO217_RS09290 glycerophosphoryl synthase: 3'-nucleotidase: glutathione 3-hydroxyacyl- 3-hydroxyacyl- 3-hydroxyacyl- RecU: recU RS09605 CMP adenine EO217_RS08010 EO217_RS08010 tetrahydrofolate activating EO217_RS10050 formate formate synthase large dehydrogenase: adenine deaminase: ade synthetase/guanosine- guanosine 3'- SAH phosphodiesterase: diester phosphodiesterase: EO217_RS13275 EO217_RS13005 synthetase NAD(P)H- ACP ACP ACP subunit: carB uridine protein: nrdG an active mannosyl-glycoprotein Holliday phosphoribosyltransferase: 3',5'-bis(diphosphate) 3'- a tRNA precursor a tRNA precursor [+ 2 isozymes] [+ 2 isozymes] ligase: phosphodiesterase: EO217_RS13340 a (6S)-5- 5-chloro-5- dependent glycerol- subunit: carB guaB (d)CMP kinase: diphosphate 5'- a flavodoxin ribonucleoside EO217_RS13340 2',3'-cyclic-nucleotide GshB: gshAB dehydratase dehydratase dehydratase junction EO217_RS03035 with a 5' with a 5' EO217_RS03225 met 5'-deoxyadenosine endo-beta-N- formyltetrahydrofolate adenine deoxyribose asp carbamoyl phosphate asp EO217_RS02010 pyrophosphohydrolase: triphosphate 3'- 5'-methylthioadenosine/ a 10- sn-glycerol an N- EO217_RS05330 sn-glycerol 3-phosphate FabZ: fabZ FabZ: fabZ FabZ: fabZ inosine-uridine preferring α-D-galactopyranose α-D-galactopyranose semiquinone triphosphate acetylglucosamidase: sn-glycerol ser 2'-phosphodiesterase: ophthalmate a (2E,6Z)- resolution resolvaseof nitrite nitrite EO217_RS11860 adenosylhomocysteine extension and extension and a 3-phosphate acylethanolamine anandamide 3-phosphate 1-phosphate dehydrogenase: a trans-hexacos- a (2E)-docos- RS01605 XMP hypoxanthine diphosphatase: formyltetrahydrofolate reductase a glycopeptide- EO217_RS00075 RuvX: ruvX carbamoyl phosphate nucleoside hydrolase: CDP a long 3' trailer short 3' extension N-acetyl-D-EO217_RS10760 3-phosphate octadecadienoyl- recombinational formate formate EO217_RS11860 nucleosidase: D-mannosyl- a ribonucleoside EO217_RS06235 2-enoyl-[acp] 2-enoyl-[acp] EO217_RS06485 ribonuclease galactokinase: galactokinase: bifunctional glucosamine- [acp] junction aspartate AMP EO217_RS07750 N 4 -N-acetyl- 3'-phosphate sn-glycerol xanthosine-5'- xanthine EO217_RS08015 EO217_RS08015 methylenetetrahydrofolate asparagine formation of two carbamoyltransferase P protein uridine kinase: phosphoribosyltransferase: D-glucosamine 3-phosphate aspartate phosphate:L- uracil ribonuclease PH: component: dehydrogenase/ intact strands catalytic subunit: GTP ppGpp S-ribosyl-L-homocysteine α-D-galactose α-D-galactose Peptide RS12730 Peptide carbamoyltransferase glutamine amido- EO217_RS09405 bifunctional pyr operon EO217_RS02470 UDP-α-D-glucose UDP-α-D-glucose methenyltetrahydrofolate EO217_RS03260 EO217_RS02950 rnpA 1-phosphate 1-phosphate ligase (AMP- transcriptional regulator/uracil hypoxanthine cyclohydrolase: catalytic subunit: ribonuclease P adenosine a (3R)-3- a (3R)-3- phosphoribosyltransferase S-ribosylhomocysteine a peptidoglycan 1-myristoyl- EO217_RS03260 forming): guaA phosphoribosyltransferase: hpt a tRNA EO217_RS13965 a peptidoglycan quinoxaline-2- glycerophosphoglycerol a holo [PedN acyl- (S)-2- [DNA] nucleoside-diphosphate nucleoside- lyase: EO217_RS08115 protein component: aryl-carrier protein dimer with a palmitoleoyl-[acp] sn-glycerol 2',3'-cyclic glu hydroxytetracosanoyl- hydroxyicosanoyl- glu ala ser PyrR: pyrR precursor with carboxyl adenylate inosine carrier protein] aminobutanoate Peptide RS12235 Peptide N-carbamoyl-L-aspartate diphosphate GDP EO217_RS12725 a 5,10- N-acetylmuramoyl- glycerophosphodiester monophosphate DNA polymerase [acp] [acp] kinase: EO217_RS07325 acyl carrier pentapeptide 1-acyl-sn-glycerol-3-phosphate 2',3'-cyclic-nucleotide ACP S- 3-hydroxyacyl- 3-hydroxyacyl- GMP uracil IMP bifunctional (p)ppGpp a 5' extension a tRNA precursor methenyltetrahydrofolate L-alanine amidase: inosine-uridine bifunctional bifunctional L-serine kinase: pyrophosphokinase: AI-2 stems (meso- phosphodiesterase: malonyltransferase: III subunit epsilon: N-carbamoyl-L-aspartate phosphoribosyltransferase: protein: acpP 3-phosphate 2'-phosphodiesterase: glutamate- ACP ACP glutamate- ammonia- UMP EO217_RS07325 EO217_RS11860 synthetase/guanosine- with a short EO217_RS02435 N-acetylmuramoyl- EO217_RS13340 preferring EO217_RS05870 dihydroorotase: ribonuclease: bifunctional acyl carrier protein: diaminopimelate acyltransferase: EO217_RS00075 fabD dehydratase dehydratase guanylate kinase: EO217_RS12625 3',5'-bis(diphosphate) 3'- 3' extension nucleoside -cysteine -cysteine lyase, EO217_RS03265 methylenetetrahydrofolate [+ 5 isozymes] containing)L-alanine amidase: DNA polymerase Peptide RS02890 Peptide EO217_RS03590 (d)CMP kinase: adenine and rnpA ditrans,octacis- EO217_RS14525 EO217_RS119151-myristoyl-2- glycerophosphoryl multifunctional 2',3'- ACP S- ligase GshA/ FabZ: fabZ FabZ: fabZ ligase GshA/ iron-sulfur- dihydroorotase: pyrophosphohydrolase: a quinoxaline-2- EO217_RS02435a peptidoglycan hydrolase: adenosine salvage I ribonuclease PH: dehydrogenase/ diester malonyltransferase: III subunit epsilon: EO217_RS03265 guanylate kinase: EO217_RS02010 superpathway of pyrimidine deoxyribonucleoside salvage EO217_RS11860 a peptidoglycan undecaprenyldiphospho- L-alanyl-γ-D- dimer with palmitoleoyl- EO217_RS06485 cyclic-nucleotide 2'- glutathione 3-hydroxyacyl- 3-hydroxyacyl- glutathione dependent, (S)-dihydroorotate (2R,4S)-2-methyl-2,4- methenyltetrahydrofolate AMP carboxyl-[aryl- [+ 5 isozymes] acyl-carrier protein EO217_RS00845 UMP kinase: EO217_RS02950 pentapeptide N-acetyl-(N- sn-glycerol phosphodiesterase: phosphodiesterase/ EO217_RS08765 synthetase ACP ACP synthetase subunit EO217_RS11015 carrier protein] glutamyl-meso-2,6- pentapeptide hypoxanthine D-ribofuranose a malonyl[PedN GDP dihydroxydihydrofuran-3-one cyclohydrolase: EO217_RS05330 a nucleoside 5'- 2+ 2+ (S)-dihydroorotate dihydroorotate EO217_RS05110 2'-deoxycytidine acetylglucosaminyl)muramate diaminopimeloyl- stem (meso- 3-phosphate 5'-nucleotidase/ acyl-carrier GshB: gshAB dehydratase dehydratase GshB: gshAB beta: sdaAB Mg RS03870 Mg adenosine EO217_RS13965 sn-glycerol γ-L-glutamyl-(S)- monophosphate γ-L-glutamyl- an uncharged glycerol 3'-nucleotidase: FabZ: fabZ FabZ: fabZ dehydrogenase GDP UDP adenine and adenosine salvage III D-alanyl-D-alanine diaminopimelate protein] pyruvate dihydroorotate oxidase: purine-nucleoside tRNA a 5,10- 3-phosphate 2-aminobutanoate a trans-tetracos- a (2E)-icos- D-alanine electron transfer subunit: cytidine deaminase: Aromatic Compound containing) EO217_RS13005 EO217_RS03625 phosphorylase: methylenetetrahydrofolate 2-enoyl-[acp] 2-enoyl-[acp] nucleoside-diphosphate EO217_RS10080 Biosynthesis 2+ 2+ EO217_RS03280 EO217_RS10050 (2R,4S)-2-methyl-2,3,3,4- 3'-AMP Mg RS07320 Mg kinase: EO217_RS07325 nucleoside- GDP adenine dCMP tetrahydroxytetrahydrofuran PRPP orotate PRPP orotate 2'-deoxyuridine purine-nucleoside chorismate biosynthesis I UDP-glucose-- UDP-glucose-- diphosphate reductase: nrdE UTP purine-nucleoside UDP-glucose UDP-glucose (d)CMP kinase: phosphorylase: deoD hexose-1-phosphate hexose-1-phosphate queuosine biosynthesis 4-epimerase 4-epimerase orotate kinase: phosphorylase: EO217_RS02010 adenine UDP-N-acetyl-α-D-muramoyl- an odd numbered ditrans,octacis- guanosine DNA with adenine:7,8- 1939 a metal a metal orotate inosine-5'-phosphate biosynthesis I thymidine kinase: D-erythrose uridylyltransferase: uridylyltransferase: Polymeric Compound D-cellobiose a uracil EO217_RS07325 CTP synthase: EO217_RS10050 GalE: galE GalE: galE a (5Z)-tetradec- a holo [PedD acyl- a holo [BryU acyl- malonate RS14845 phosphoribosyltransferase: phosphoribosyltransferase: 4-phosphate galT galT L-alanyl-γ-D-glutamyl- D-alanyl-D-alanine straight chain undecaprenyldiphospho- 6'-phosphate a purine a malonyl-[acp] 2',3'-cyclic dihydro-8- in 23S rRNA asp cation cation EO217_RS12590 dCDP 3-deoxy-7- Degradation arsenate 5-enoyl-[acp] carrier protein] carrier protein] IMP EO217_RS03295 dGDP EO217_RS13375 purine-nucleoside adenine preQ α-D-glucopyranose α-D-glucopyranose meso-2,6-diaminopimelate 2,3,4-saturated N-acetyl-(N-acetyl-β-D- 6-phospho- ribonucleoside monophosphate oxoguanine mismatch 23S rRNA biotin- EO217_RS03295 [+ 3 isozymes] 0 α UDP-α-D-galactose UDP-N- beta- 2',3'-cyclic-nucleotide ACP S- ACP S- A/G-specific bifunctional AIR thymidine phosphoheptulonate UDP- -D-galactose acyl-CoA D-aspartate purine-nucleoside multifunctional 2',3'- phosphorylase: deoD nucleoside- phosphoribosyltransferase: 1-phosphate 1-phosphate pectin degradation II acetylmuramoyl- fatty acid glucosaminyl)muramoyl- beta- 2'-phosphodiesterase: malonyltransferase: malonyltransferase: adenine (uracil(1939)-C(5)) independent synthase: aroF phosphorylase: ketoacyl- aspartate orotidine 5'-phosphate GTP nucleoside- adenosine diphosphate kinase: EO217_RS03035 3-deoxy- synthetase: L-alanyl-γ-D-glutamyl-L- glucosidase: -methyltransferase cyclic-nucleotide 2'- malonate a metal a metal orotidine 5'-phosphate 5-(carboxyamino) dUMP tripeptide--D-alanyl- an odd numbered ACP EO217_RS00075 fabD fabD glycosylase: transaminase/ RS03550 CTP thymidine kinase: EO217_RS07325 D-arabino- phospho- phospho- a methyl-esterified EO217_RS03490 D-aspartate ligase: ascB deoD RlmD: rlmD phosphodiesterase/ diphosphate imidazole ribonucleotide preQ D- alanine ligase: lysyl-D-alanyl-D-alanine synthase mutY decarboxylase cation cation 1 straight chain ditrans,octacis- multifunctional 2',3'- ACP S- ACP S- 5'-nucleotidase/ aspartate 4- orotidine-5'-phosphate kinase: adenosine thymidylate EO217_RS12590 AMP heptulosonate sugar mutase: sugar mutase: homogalacturonan diphosphate AMP EO217_RS04895 [+ 2 isozymes] purine-nucleoside subunit orotidine-5'-phosphate synthase: purK dCTP pectin esterase: UDP-N-acetyl-α-D-muramoyl-L-EO217_RS09365 2,3,4-saturated undecaprenyldiphospho-N- II: fabF malonyltransferase: malonyltransferase: an apurinic site 23S rRNA decarboxylase: deaminase: 7-phosphate tRNA EO217_RS06125 EO217_RS06125 lactose and galactose D-glucopyranose phosphorylase: a (7Z)-3-oxo- cyclic-nucleotide 2'- adenine 3'-nucleotidase: decarboxylase: pyrF EO217_RS07325 synthase: [+ 3 isozymes] L-rhamnose degradation I D-glucopyranose (uracil(1939)-C(5)) beta: mdcD decarboxylase: pyrF degradation I EO217_RS11645 alanyl-γ-D-glutamyl-meso-2,6- fatty acyl CoA acetyl-(N-acetylglucosaminyl) acyl-carrier protein hexadec-7- phosphodiesterase/ a malonyl-EO217_RS08765 a malonyl- EO217_RS08765 within DNA EO217_RS13005 EO217_RS01115 N5-CAIR EO217_RS04950 EO217_RS02085 3-dehydroquinate guanosine(34) phosphomannomutase/ phosphomannomutase/ 6-phosphate EO217_RS10050 2+ 2+ orotidine-5'-phosphate a homogalacturonan diaminopimeloyl-D-alanyl-D-alanine muramoyl-L-alanyl-γ-D- -methyltransferase acetate Zn RS08200 Zn orotidine-5'-phosphate xanthine and transglycosylase enoyl-[acp] 5'-nucleotidase/ [PedD acyl- [BryU acyl- ala decarboxylase: pyrF dGTP superpathway of synthase: aroB phosphoglucomutase: phosphoglucomutase: lactose 6'- α-L-rhamnopyranose β ribose-1-arsenate a purine base RlmD: rlmD inosine decarboxylase: pyrF 5-(carboxyamino)imidazole xanthosine salvage glutamyl-N-( -D-asparatyl) 3'-nucleotidase: carrier protein] carrier protein] a 5- adenosine nucleotides inosine Tgt: tgt EO217_RS07925 EO217_RS07925 phosphate L-rhamnose polygalacturan 1,4- UMP 6-phospho-beta- -L-lysyl-D-alanyl-D-alanine EO217_RS13005 methyluracil 1939 UMP ribonucleotide mutase: purE 3-dehydroquinate a 7-aminomethyl-7- α de novo biosynthesis I purine deoxyribonucleosides salvage D-glucopyranose galactosidase: mutarotase: -galacturonidase: deazaguanosine 34 D-glucopyranose L-arabinose 3'-GMP in 23S rRNA Zn 2+ RS10950 Zn 2+ (d)CMP kinase: asp purine-nucleoside rhaM EO217_RS11635 CAIR xanthosine type I 3- 6-phosphate 6-phosphate lacG EO217_RS02010 phosphorylase: in tRNA degradation I D-galactopyranose β IMP asp dTMP -L-rhamnopyranose purine-nucleoside dehydroquinate tRNA preQ1(34) S- 6-phosphate D-galactopyranuronate UMP kinase: EO217_RS10050 superpathway of pyrimidine adenylosuccinate 2'-deoxyguanosine 2'-deoxyadenosine phosphorylase: deoD dehydratase: aroD L-arabinopyranose L-rhamnose dTMP kinase: adenosylmethionine galactose-6- 38- EO217_RS05110 nucleobases salvage phosphoribosylaminoimidazolesuccinocarboxamide purine-nucleoside deoxynucleoside deoxynucleoside undecaprenyldiphospho- (15Z)- sn-glycero-3- 1-palmitoyl- cytidine a uridine a [protein]-L- biotin RS09615 biotin synthase: EO217_RS13485 purine-nucleoside ribosyltransferase- L-arabinose isomerase: a (3Z)-dodec- a ribonucleoside a holo [BryP acyl- a uridine in tRNA aminomalonate superpathway of 5-aminoimidazole synthase: EO217_RS02500 phosphorylase: deoD 3-dehydroshikimate phosphate N-acetylmuramoyl-L- acyl-carrier protein a palmitoleoyl-[acp] sn-glycerol a malonyl-[acp] 2',3'-cyclic a malonyl-[acp] UDP EO217_RS10205 kinase: kinase: isomerase: ribose tetracosenoate phosphoethanolamine 5'-monophosphate carrier protein] 40 in tRNA methionine ribonucleotide biosynthesis uracil dTMP kinase: tmk phosphorylase: isomerase QueA: queA isomerase: rhaA UDP-N-acetyl- acyl-CoA 3-enoyl-[acp] tRNA- bifunctional peptide- adenylo-succinate EO217_RS09125 EO217_RS09125 trehalose degradation III aldehydo-D- alanyl-γ-D-glutamyl-meso glycerophosphoryl ACP S-malonyltransferase: 1-acyl-sn-glycerol-3-phosphate beta- monophosphate multifunctional 2',3'- ACP S- RluA family beta- 34 araA phosphorylation α-D-glucosamine 2',3'-cyclic-nucleotide bifunctional pyr operon hypoxanthine EO217_RS10050 shikimate an epoxyqueuosine lacA lacB synthetase: pseudouridine dihydrouridine aspartate methionine SAICAR dTDP xanthine L-ribulose keto-L-rhamnulose galacturonate -2,6-diaminopimeloyl- diester EO217_RS08765 3-phosphate ketoacyl- cyclic-nucleotide 2'- malonyltransferase: ketoacyl- nucleoside- PRPP transcriptional regulator/uracil [+ 2 isozymes] [+ 2 isozymes] dehydrogenase: α α 2'-phosphodiesterase: riboflavin RS14915 riboflavin adenylosuccinate in tRNA , -trehalose β D-tagatofuranose D-alanyl-D-alanine undecaprenyldiphospho- EO217_RS03490 phosphodiesterase: fabD synthase: synthase: transaminase/ (S)-S-oxide diphosphate kinase: nucleoside- dGMP dAMP -D-ribopyranose glucuronate ACP S- acyltransferase: ACP EO217_RS00075 phosphodiesterase/ ACP amidophosphoribosyltransferase: phosphoribosyltransferase lyase: purB xanthine xanthine aroE epoxyqueuosine 6-phosphate 6-phosphate muramoylpentapeptide beta-N- EO217_RS05330 EO217_RS03245 EO217_RS10675 aspartate 4- reductase EO217_RS07325 adenylosuccinate D-ribose isomerase: (15Z)- malonyltransferase: fabD EO217_RS11915 synthase 5'-nucleotidase/ ACP S- synthase dUDP EO217_RS02520 PyrR: pyrR diphosphate kinase: AMP diphosphate 1-palmitoyl-2- multifunctional 2',3'- decarboxylase: MsrA: msrA lyase: purB phosphoribosyltransferase: phosphoribosyltransferase: reductase QueH: pyranase: tagatose-6- acetylglucosaminyltransferase: tetracosenoyl-CoA glycerophosphodiester II: fabF 3'-nucleotidase: [+ 4 isozymes] tRNA II: fabF 5-phospho-β- EO217_RS07325 shikimate uxaC a malonyl-[acp] palmitoleoyl- a (5Z)-3-oxo- malonyltransferase: 38- a 3- uracil EO217_RS02470 EO217_RS02470 EO217_RS12560 lipid II (murGmeso acyl-carrier protein cyclic-nucleotide 2'- a pseudouridine EO217_RS01115 [+ 2 isozymes] nucleoside- D-ribosylamine AMP trehalose-6- L-ribulose 5- rbsD phosphate L-rhamnulofuranose phosphodiesterase: EO217_RS13005 EO217_RS08765 dihydrouridine a protein-L- a sugar RS07830 a sugar UDP sn-glycerol acyl-carrier protein tetradec-5- phosphodiesterase/ a malonyl- 40 in tRNA oxodocosanoyl- diphosphate kinase: gln UTP phosphoribosyltransferase: AICAR hypoxanthine dTTP shikimate kinase: a queuosine 34 phosphate phosphate β-D-ribofuranose kinase: lacC D-tagaturonate diaminopimelate containing) EO217_RS13340 synthase 3-phosphate enoyl-[acp] a ribonucleoside [BryP acyl- gly methionine- [acp] phosphoribosylamine- EO217_RS12625 sn-glycerol 5'-nucleotidase/ EO217_RS07325 phosphoribosyltransferase: hpt XMP EO217_RS04660 in tRNA phosphorylase: L-ribulose-5- D-tagatofuranose rhamnulokinase: DusB: dusB (S)-S-oxide -glycine ligase: purD UMP bifunctional ethanolamine 3'-nucleotidase: carrier protein] a 5,6- adenylate kinase: EO217_RS10590 1,6-bisphosphate rhaB 3-phosphate dUTP CTP synthase: dGDP dADP phosphate 4- dihydrouridine a sugar RS05020 a sugar phosphoribosylaminoimidazolecarboxamide EO217_RS09890 shikimate 3- EO217_RS13005 (d)CMP kinase: IMP epimerase: tagatose- L-rhamnulose dUTP diphosphatase: EO217_RS13375 GAR formyltransferase/IMP cyclohydrolase: purH phosphate 3'-cmp in tRNA EO217_RS02010 nucleoside- nucleoside- beta- EO217_RS01580 D-ribofuranose bisphosphate 1-phosphate D-fructuronate EO217_RS10830 CTP guanine and guanosine salvage 3-phosphoshikimate 1- phosphoribosylglycinamide UMP kinase: FAICAR ADP diphosphate diphosphate lipoprotein posttranslational phosphoglucomutase: aldolase: lacD rhamnulose- carboxyvinyltransferase: L-ribulose-5- dUMP EO217_RS05110 kinase: kinase: modification ribokinase: a sugar RS12405 a sugar formyltransferase: purN pgmB phosphate 4- tagatose- 1-phosphate a 2-deoxy-D- RNase III mRNA 1-stearoyl- adenine 1518 / uridine 2'3'-cyclic 1-arachidinoyl- an [apo BCAA bifunctional guanine and guanosine salvage II aroA rbsK coenzyme A NADP + 18-hydroxyoleate a nucleobase (R)-pantoate NMN acetyl-CoA ADP EO217_RS07325 EO217_RS07325 a [prolipoprotein]- bisphosphate aldolase: rhaD processing a palmitoyl-[acp] sn-glycerol 1519 monophosphate sn-glycerol dehydrogenase asp thymidylate synthase: UDP phosphoribosylaminoimidazolecarboxamide guanosine 5-enolpyruvoyl- beta- epimerase: ribosyl-base adenine in 16S rRNA dIDP FGAR D-ribofuranose 2',3'-cyclic-nucleotide 6 EO217_RS02085 CDP reductase: shikimate 3- L-cysteine phosphoglucomutase: EO217_RS12415 aldolase: lacD CoA-disulfide reductase: acyl-CoA nucleoside 2- substrateribonuclease III: 3-phosphate 16S rRNA 2-dehydropantoate multifunctional 2',3'- 3-phosphate1-acyl-sn-glycerol- E2 protein] N acetyl-CoA nucleoside-diphosphate formyltransferase/IMP cyclohydrolase: purH purine-nucleoside (S)-lactaldehyde DHAP 1-acyl-sn-glycerol- bifunctional serine serine nrdE dGTP dATP 5-phosphate EO217_RS08535 synthetase: deoxyribosyltransferase: (adenine(1518)-N(6)/ 2'-phosphodiesterase: 2-reductase: cyclic-nucleotide 2'- -dihydrolipoyl- carboxylase nucleoside- phosphorylase: phosphate prolipoprotein β-D-glucopyranose pgmB β-D-glucose D-xylulose D-glyceraldehyde EO217_RS09735 3-phosphate 3-phosphate aspartate RS06950 dTMP phosphoribosylformylglycinamidine kinase: EO217_RS07325 guanosine DHAP EO217_RS00075 dihydrolipoamide diphosphate thr thr chorismate diacylglyceryl 5-phosphate 3-phosphate pyridine nucleotide- EO217_RS03490 EO217_RS04445 adenine(1519)-N(6))- EO217_RS07255 phosphodiesterase/ acyltransferase: L-lysine biotin carboxyl EO217_RS10050 1-phosphate 6-phosphate ribonuclease III: acyltransferase: dehydrogenase: transaminase/ dTMP kinase: synthase: purS purQ purL UTP IMP dADP disulfide oxidoreductase: dimethyltransferase 5'-nucleotidase/ carrier kinase: synthase: transferase: 18-hydroxyoleoyl- nucleoside EO217_RS10860 EO217_RS11915 multifunctional 2',3'- 2-dehydropantoate a 1-arachidonoyl-EO217_RS11915 aspartate 4- purine-nucleoside AMP diphosphate RNase III 1-stearoyl- EO217_RS07725 EO217_RS07325 EO217_RS13485 dCDP aroC EO217_RS06240 EO217_RS07000 deoxyribosyltransferase: 6 RsmA: rsmA1518 cyclic-nucleotide 2'- 2-reductase: 3'-nucleotidase: protein: accB FGAM CTP synthase: phosphorylase: deoD CoA an mRNA fragment processing 2-palmitoyl- N -dimethyladenine 2-acyl-sn-glycerol decarboxylase: serine serine dTMP kinase: tmk nucleoside- chitobiose degradation + acyl-carrier protein EO217_RS13005 dihydrolipoyl RS08925 nucleoside- EO217_RS13375 a [prolipoprotein]- Amine and Polyamine Degradation H NADPH CoA-disulfide EO217_RS07380 /N 6 -dimethyladenine 1519 phosphodiesterase/ EO217_RS09000 3-phosphate EO217_RS01115 [+ 3 isozymes] dITP guanine guanine a 2-deoxy-D- product mRNA sn-glycerol 1-(β-D dehydrogenase: thr thr diphosphate chorismate S-1,2-diacyl-sn- 5'-nucleotidase/ an [apo BCAA dTDP diphosphate kinase: phosphoribosylformylglycinamidine CTP D-mannose N,N'- fructose degradation a nucleobase 3-phosphate in 16S rRNA 2-dehydropantoate ribofuranosyl) oxaloacetate malonyl-CoA kinase: D-xylose trehalose degradation ribosyl-base lpdA EO217_RS07325 cyclo-ligase: EO217_RS02525 glyceryl-L-cysteine 3'-nucleotidase: dehydrogenase nucleoside- xanthine xanthine degradation diacetylchitobiose superpathway of N-acetylglucosamine, nicotinamide EO217_RS07325 degradation I I (low osmolarity) β-D-fructofuranose EO217_RS13005 E2 protein] N 6 phosphoribosyltransferase: phosphoribosyltransferase: 6'-phosphate N-acetylmannosamine and N- serine serine diphosphate kinase: dCTP signal peptidase II: D-mannopyranose RS06945 AIR α,α-trehalose 1-phosphate 3'-UMP -lipoyl-L-lysine EO217_RS07325 EO217_RS02470 EO217_RS02470 D-xylose 1-phosphofructokinase: acetylneuraminate degradation thr thr dATP EO217_RS03240 6-phosphate N-monoacetylchitobiose 6-phosphate hypoxanthine hypoxanthine mannose-6- pfkB N-acetylneuraminate dTTP phosphate 6'-phosphate phosphoribosyltransferase: hpt phosphoribosyltransferase: hpt an (S-diacyl- a lipoprotein 1-phosphofructokinase: alpha,alpha- a 3-methyl- 1-stearoyl- a carboxy- a guanine 34 sn-glyceryl) D-xylulose isomerase, 6-phospho- pfkB a [formate C 7-hydroxylaurate a 2,3,4-saturated a 2,3,4-saturated 2- queuine a ribonucleoside an L-aspartyl- L-cysteate sn-glycerol V-type ATP signal peptide β-D-fructose 1,6- SAM a reduced flavodoxin branched 2,3,4- a stearoyl-[acp] sn-glycerol cys adenylated-[ThiS a purine 3'-AMP + + class I: manA beta- phosphotrehalase: N-acetyl-D- in tRNA 3'-phosphate [tRNA Asn ] 3-phosphate IDP H H GMP GMP -L-cysteinyl- acetyltransferase]-glycine acyl-CoA fatty acyl-[acp] lysophosphatidate ribonucleoside synthase F6P treC bisphosphate mannosamine pyruvate 1-acyl-sn-glycerol- saturated fattyacyl-CoA acid 1-acyl-sn-glycerol-3-phosphate sulfur-carriercysteine protein] tRNA multifunctional 2',3'- Asp-tRNA(Asn) multifunctional 2',3'- bifunctional glycerol-3- [apolipoprotein] xylulose kinase: glucosidase: purine-nucleoside synthetase: guanosine(34) aspartate phosphate 1-O- nucleoside- EO217_RS10705 ascB formate lyase- 3-phosphate synthetase: 3-phosphate desulfurase: cyclic-nucleotide 2'- /Glu-tRNA(Gln) cyclic-nucleotide 2'- EO217_RS03490 phosphorylase: diphosphate D-glucopyranose activating acyltransferase: EO217_RS03490 acyltransferase: EO217_RS13255 transglycosylase phosphodiesterase/ amidotransferase: phosphodiesterase/ transaminase/ acyltransferase D-xylulose [+ 2 isozymes] D-glucopyranose a 3-methyl- deoD kinase: F0F1 ATP Fatty Acid and Lipid Biosynthesis 6-phosphate Tgt: tgt aspartate 4- PlsY: plsY + + a peptide N-acetyl-D- N-acetyl-D- protein: pflA a [formate C 7-hydroxylauroyl- EO217_RS11915 branched EO217_RS11915 [+ 2 isozymes] 5'-nucleotidase/ gatB gatA gatC 5'-nucleotidase/ 1-(18- H H 5-phosphate AMP diphosphate a 2,3,4-saturated 1-stearoyl-2- purine-nucleoside an L-asparaginyl- EO217_RS07325 synthase an N-acyl-(S- a flavodoxin CoA diphosphate AMP 34 3'-nucleotidase: 3'-nucleotidase: decarboxylase: glucosamine D-glucosamine mannosamine met 5'-deoxyadenosine acetyltransferase]- 1,2-diacyl-sn 2,3,4-saturated stearoyl-sn a thiocarboxy- a queuosine Asn hydroxyoleoyl) diacyl-sn-glyceryl) semiquinone acyl-carrier protein acyl-carrier protein AMP ala phosphorylase: guanine [tRNA ] EO217_RS13005 EO217_RS01115 ITP Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis palmitate biosynthesis II (bacteria and plant cytoplasm) 6-phosphate 6-phosphate glycin -2-yl radical -glycerol 3- fatty acyl-CoA -glycerol 3- [ThiS-Protein] in tRNA EO217_RS13005 -sn-glycrol palmitoleate cis-vaccenate biotin-carboxyl carrier -L-cysteinyl- EO217_RS10050 putative N- phosphate phosphate α-D-ribose- a ribonucleoside 3-sulfopyruvate 3-phosphate biosynthesis I (from biosynthesis protein assembly [lipoprotein] a purine base adenosine ammonium RS03795 ammonium [2Fe-2S] iron-sulfur acetylmannosamine- 1-phosphate L-cysteine biosynthesis lipoate biosynthesis glutathione- acyl carrier an acetoacetyl-[acp] (5Z)-dodec-5-enoate) cluster biosynthesis citrate lyase activation lipoate salvage II hydroxymethylpyrimidine di-trans,poly-cis a [biotin carboxyl- 6-phosphate VI (from L-methionine) and incorporation II peroxide protein activation a (5Z)-dodec- a palmitoleoyl-[acp] salvage -undecaprenyl carrier protein]-L-lysine 2-epimerase: a [lipoyl-carrier redox reactions 5-enoyl-[acp] beta- phosphate biosynthesis acetoacetyl-[acp] beta-ketoacyl- biotin--[acetyl-CoA- EO217_RS03765 L-cysteine desulfurase 3'-dephospho-CoA 6 4-amino-2-methyl-5- octanoate an apo acyl- a (2R)-2-hydroxy 1-cis-vaccenoyl- 1-cis-vaccenoyl- 1-myristoyl- 5-dehydro- protein]-N - reductase: fabG ketoacyl- 5-oxo-L-proline metabolism a 2,3,4-saturated α a nucleoside salicin 6- γ-L-glutamyl- met (2E,6E)-farnesyl GSSG ACP synthase carboxylase] ligase: a cis- sn-glycerol an L-rhamnoside a ribonucleic acid a purine 2'- NaMN sn-glycerol- sn-glycerol lipoyl-L-lysine pyrimidinemethanol IPP lipoate-- carrier protein ACP N-acetylmannosamine- even numbered fatty acid a palmitoleoyl-[acp] sn-glycerol- phosphate gly 4-deoxy-D- triphosphoribosyl- methionine 6-hydroxymethyl-dihydropterin bifunctional II: fabF EO217_RS10510 Nucleoside and Nucleotide Degradation vaccenoyl-[acp] 3-phosphate triphosphate D-alanine IMP cysteine diphosphate protein ligase: holo-ACP synthase: a (3R)-3- a [protein] with a [protein] with 6-phosphate straight chain 2,3,4- acyl-CoA 3-phosphate alpha-L- deoxyribonucleoside 6-phospho- multifunctional 2',3'- 3-phosphate 3-phosphate glucuronate dephospho-CoA adenosyltransferase: diphosphate biosynthesis I hydroxymethylpyrimidine ditrans,polycis a (7Z)-3-oxotetradec- synthase 1-acyl-sn-glycerol- glycerol-3- DNA-directed 1-acyl-sn-glycerol- bifunctional 1-acyl-sn-glycerol- 5-dehydro- desulfurase: EO217_RS09355 a [biotin carboxyl- an N-terminal an N-terminal acyl-CoA synthetase: rhamnosidase: purine-nucleoside a [lipoyl-carrierEO217_RS13585 hydroxybutanoyl-[acp] 7-enoyl-[acp] an (11Z)-3-II: fabF 2-epimerase: saturated fatty acid 3-phosphate phosphate 1-O- RNA polymerase beta- cyclic-nucleotide 2'- 3-phosphate 3-phosphate 4-deoxy-D- GMP synthase CitG: citG (R)-lipoate EO217_RS11315 kinase/ -undecaprenyl- a holo acyl- carrier protein]-N phosphorylase: glutamate- EO217_RS07585 6 glutathione- L-glutamine L-glutamate purine nucleotides degradation II (aerobic) superpathway of purine deoxyribonucleosides degradation EO217_RS05565 synthetase: EO217_RS03490 EO217_RS03395 glucosidase: phosphodiesterase/ diphosphate protein] N - 7 oxooctadec- 6 acyltransferase: acyltransferase subunit beta: acyltransferase: acyltransferase: glucuronate reductase: [+ 2 isozymes] SAM phosphomethylpyrimidine carrier protein 3-hydroxyacyl- 3-oxo-cis-∆ - -biotinyl-L-lysine aEO217_RS03490 (R)-2-hydroxy even a non deoD -cysteine [+ 2 isozymes] lipoate-- GTP octanoyl-L-lysine disulfide N-acetyl-D- ascB 5'-nucleotidase/ kinase: thiD synthase [(2E ACP dehydratase tetradecenoyl- 11-enoyl-[acp] numbered straight a 2,3,4-saturated EO217_RS119151-cis-vaccenoyl- PlsY:1-cis plsY-vaccenoyl- rhamnosylated β-L- EO217_RS06395 1,2-dicis- EO217_RS11915 ligase GshA/ 1-myristoyl-2-EO217_RS11915 isomerase: guaC 2'-(5''-triphospho-α-D- reductase: glucosamine diphosphate AMP AMP diphosphate purine-nucleoside [+ 2 isozymes] 3'-nucleotidase: an S-sulfanyl-[L- protein ligase: GTP ,6E)-farnesyl- FabZ: fabZ 3-oxo-cis- chain 2,3,4-saturated fatty acyl CoA acyl-carrier protein sn-glycerol- rhamnosyl rhamnopyranose [+ 5 isozymes] vaccenoyl- glutathione palmitoleoyl- 3-deoxy-D-kduI ribosyl)-3'-dephospho-CoA hydroxymethylpyrimidine/ thiamine salvage III [acp] 6-phosphate 2-palmitoleoyl- phosphorylase: β-D-glucose EO217_RS13585 cyclohydrolase gor vaccenoyl- AMP 2'-deoxyguanosine acyl-carrier protein EO217_RS13005 GMP cysteine desulfurase] diphosphate 3-hydroxyacyl- reductase: fabG fatty acyl CoA sn-glycerol- 3-phosphate acceptor a ribonucleic acid salicyl alcohol phosphatidate synthetase sn-glycerol glycero-2,5- citrate lyase holo- 7,8- phosphomethylpyrimidine a [biotin carboxyl- a [protein] with N-acetylglucosamine- 2-deoxy-α- EO217_RS10050 6-phosphate β-D- I FolE: folE specific]: a [lipoyl-carrier a (3R,7Z)-3- [acp] 2'-deoxyadenosine GshB: gshAB 3-phosphate hexodiulosonate (lipoyl)adenylate dihydroneopterin kinase: EO217_RS03495 menaquinol-7 biosynthesis ACP dehydratase carrier-protein dimer]- an N-terminal 5- 6-phosphate 3-phosphate ribosylnicotinate [acyl-carrier protein] EO217_RS05100 6 thiamine hydroxytetradec- reductase: multifunctional 2',3'- D-ribose 1- a purine base SAH HMP-P di-trans,octa-cis protein]-N -[(R) FabZ: fabZ 6 deacetylase: nagA norophthalmate synthase: citX 3'-triphosphate thiamine N -biotinyl-L-lysine oxo-L-proline γ cyclic-nucleotide 2'- phosphate thiamine RS10980 thiamine lipoate-- -undecaprenyl -dihydrolipoyl]- glutathione all-trans- 7-enoyl-[acp] fabG -L-glutamyl purine-nucleoside 1,4-dihydroxy- diphosphokinase: a (3R,11Z)-3- acetyl-CoA acetyl-CoA glutathione D-glucosamine an S-sulfanyl-[cysteine citrate lyase holo- protein ligase: bifunctional diphosphate L-lysine 5-phosphate phosphodiesterase/ IMP 5'-methylthioadenosine/ heptaprenyl a (2E)-but-2-enoyl-[acp] pyroglutamyl- adenosine phosphorylase: 6-phosphate desulfurase]-[disordered- [acyl-carrier protein] 2-naphthoate EO217_RS11065 hydroxyoctadec- carboxylase carboxylase 5'-nucleotidase/ EO217_RS13585 adenosylhomocysteine hydroxymethylpyrimidine undecaprenyl- diphosphate1,4-dihydroxy- thiamine peptidase deaminase: EO217_RS10050 2503 a 1-acyl-sn a protein-L- 11-enoyl-[acp] carboxyl: biotin carboxylase GMP adenine 1-stearoyl- 1-stearoyl- a pseudouridine 1915 5'-deoxy-5'- arbutin-6- adenine 37 form scaffold synthase: citX a [glycine- 7,8- kinase/ diphosphate enoyl-ACP 3'-nucleotidase: IMP an acyl-[acyl- a [ThiI sulfur-carrier a kanamycin sulfate RS07650 sulfate nucleosidase: 2-naphthoate diphosphate I: pcp EO217_RS04950 purine-nucleoside cys val 3'-GMP -glycerol 3- a protein methionine- dihydroneopterin 3-hydroxyacyl- EO217_RS14560 subunit: EO217_RS13005 in 23S rRNA a tRNA precursor CTP ATP an oleoyl-[acp] sn-glycerol sn-glycerol in 23S rRNA fluoroadenosine phosphate in tRNA protein] complex cleavage complex phosphomethylpyrimidine phosphatase: reductase a (2E,7Z)-tetradeca- dehydrogenase: carrier protein] protein]-L-cysteine aminoglycoside 1 [cysteine desulfurase]-S- a holo [citrate lyase EO217_RS07750 polyprenyltransferase: EO217_RS14565 EO217_RS14555 purine-nucleoside phosphorylase: 23S rRNA 3-phosphate 3-phosphate 23S rRNA cysteine purine-nucleoside 6-phospho- tRNA1(Val) multifunctional 2',3'- phosphate metalloprotease: (R)-S-oxide 6 3'-phosphate 2,7-dienoyl-[acp] ACP multifunctional 2',3'- 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- peptide- H protein] N - kinase: thiD EO217_RS02735 menA FabI: fabI guaB α-D-glucosamine (adenine(2503)-C(2) CCA tRNA phosphorylase: phosphotransferase: sulfanylcysteine:[acceptor acyl-carrier protein] S-ribosyl-L- dehydratase a [carboxyl-carrier phosphorylase: deoD 3-phosphate 3-phosphate (pseudouridine(1915)- desulfurase: beta- (adenine(37)-N6)- cyclic-nucleotide 2'- 3-phosphate EO217_RS01305 lipoyl-L-lysine di-trans,octa-cis demethylmenaquinol-7 5-oxo-L-proline adenosine cyclic-nucleotide 2'- 6-phosphate methionine protein]-cysteine hydroxymethylpyrimidine/ enoyl-ACP 6 2'-deoxyinosine )-methyltransferase nucleotidyltransferase: N(3))-methyltransferase deoD glucosidase: EO217_RS11745 methyltransferase: a purine RS02475 a purine [citrate (pro-3S)- homocysteine -undecaprenyl a butanoyl-[acp] FabZ: fabZ protein dimer]-N - phosphodiesterase/ EO217_RS10050 acyltransferase: acyltransferase: EO217_RS13255 phosphodiesterase/ acyltransferase: metalloprotease: (R)-S-oxide phosphomethylpyrimidine reductase XMP glucosamine- RlmN: rlmN a tRNA EO217_RS02060 RlmH: rlmH ascB aminoglycoside EO217_RS11910 sulfurtransferase: phosphate carboxybiotinyl-L-lysine purine-nucleoside EO217_RS11915 EO217_RS11915 an N 3 - [+ 2 isozymes] purine-nucleoside an N 6 - 5'-nucleotidase/ EO217_RS11915 EO217_RS00245 reductase lyase] ligase: citC FabI: fabI 3-hydroxyacyl- adenosine 5'-nucleotidase/ 2503 containing a 1-stearoyl-2- a 1-stearoyl 2- a [ThiI sulfur- a 1-acyl-2- EO217_RS07715 S-ribosylhomocysteine 7,8- kinase: EO217_RS03495 6-phosphate a 2-methyladenine 1915 phosphorylase: [+ 2 isozymes] phosphotransferase: 37 beta-ketoacyl- ACP deaminase: 3'-nucleotidase: purine-nucleoside phosphorylase: 5'-deoxyadenosine met acyl-carrier protein oleoyl-sn-glycerol acyl-carrier protein acyl-sn-glycerol methylpseudouridine carrier protein]-S- ala methyladenine 3'-nucleotidase: arachidonoyl- a peptide MsrB: msrB a [cysteine desulfurase]- [citrate (pro-3S)- a [lipoyl-carrier lyase: EO217_RS08115 S-adenosyl-L-methionine cycle I lipoate salvage I multifunctional 2',3'- deaminase: in 23S rRNA 3' CCA end β-D-glucose dihydroneopterin a (7Z)-tetradec- EO217_RS10050 EO217_RS13220 val EO217_RS13005 a [protein]-L- lyase] ligase: citC 6 ACP synthase dehydratase EO217_RS04950 EO217_RS13005 phosphorylase: deoD 3-phosphate 3-phosphate in 23S rRNA sulfanyl-L-cysteine hydroquinone in tRNA sn-glycerol L-cystine RS04585 L-cystine S-sulfanyl-[disordered- protein]-N - HMP-PP cyclic-nucleotide 2'- nagB 5-fluoro-5- 6-phosphate a kanamycin 1 dihydroneopterin II: fabF 7-enoyl-[acp] EO217_RS10050 methionine form scaffold menaquinol-7 FabZ: fabZ glu phosphodiesterase/ 3-phosphate an acetyl-holo [citrate lipoyl-L-lysine L-homocysteine long-chain fatty deoxy-D-ribose adenine 3'-phosphate guanosine aldolase: folB SAM (R)-lipoate beta-ketoacyl- a (2E,11Z)- inosine guanosine purine-nucleoside F6P protein] complex 5'-nucleotidase/ 1-phosphate lyase acyl-carrier protein] lipoate-- a 3-oxohexanoyl-[acp] octadeca-2,11- acid activation cysteine 6-(hydroxymethyl) ACP synthase 3'-nucleotidase: phosphorylase: protein ligase: dienoyl-[acp] chloride RS05905 chloride desulfurase: -7,8-dihydropterin II: fabF a long-chain purine-nucleoside purine-nucleoside EO217_RS13005 deoD methionine EO217_RS13585 3-oxotehexanoyl- EO217_RS07585 enoyl-ACP 2-deoxy-α-D- α 10 2-amino-4-hydroxy-6- a (9Z)-3-oxohexadec- fatty acid phosphorylase: phosphorylase: decaprenyl-diphospho-N- UDP-N-acetyl- a 2-methyl 1-myristoyl- N-acetyl- - 4-(cytidine 5'- a uracil 1498 a [lipoyl-carrier 1-palmitoyl- a [peptide] (3R,5S)-3- N -formyl-tetrahydrofolate biosynthesis heme b biosynthesis II adenosyltransferase: (lipoyl)adenylate [acyl-carrier reductase acyl-CoA N 6 -L-threonylcarbamoyladenosine 37 a (4Z)-hexadec- 1,4-dihydroxy- sn-glycerol a uracil in DNA [+ 2 isozymes] hydroxymethyldihydropteridine 9-enoyl-[acp] EO217_RS10050 EO217_RS10050 xanthosine ribose 1-phosphate acetylmuramoyl-pentapeptide α-D-glucosamine a malonyl-[acp] branched 2,3,4- a myristoyl-[acp] sn-glycerol GGPP a stearoyl-[acp] D-muramoyl- diphospho)-2-C- protein]-N 6 -[(R) sn-glycerol with N-terminal hydroxy-1- an S-sulfanyl-[cysteine (oxygen-independent) EO217_RS11315 protein] FabI: fabI synthetase: 4-enoyl-[acp] 2-naphthoate 3-phosphate in 16S rRNA arg arg L-cystathionine -modified tRNA biosynthesis undecaprenyldiphospho- saturated fatty acid uracil-DNA L-alanine(1-) methyl-D-erythritol 16S rRNA 3-phosphate β desulfurase]-S- diphosphokinase: folE lipoate-- ∆ 9 EO217_RS03490 purine-nucleoside purine-nucleoside phosphopentomutase: beta-ketoacyl- acyl-CoA 1-acyl-sn-glycerol-3-phosphate 1,4-dihydroxy- glycerol-3- N-acetylmuramoyl- 4-(cytidine 5'- -dihydrolipoyl]- 1-acyl-sn-glycerol- aspartatebeta- pyrroline-5- a tetrahydrofolate reductase: fabG 3-oxo-cis- - a long-chain RS07690 (7,8-dihydropterin- protein ligase: a cis- phosphorylase: phosphorylase: muramoylpentapeptide beta-N- 2-naphthoate glycosylase: (uracil(1498)-N(3))- L-lysine dihydrolipoyl carboxylatepyrroline-5- sulfanyl-[disordered- cystathionine uroporphyrinogen-III met SAH hexadecenoyl- deoB ACP synthase synthetase: 3-phosphate phosphate 1-O- L-alanine amidase: diphospho)- 3-phosphate aspartyl- 6-yl)methyl EO217_RS13585 a (3R)-3- vaccenoyl-[acp] acyl-CoA acetylglucosaminyltransferase: EO217_RS07140 methyltransferase: ornithine ornithine form scaffold [acp] ATP thr deoD deoD purine-nucleoside II: fabF EO217_RS03490 acyltransferase: polyprenyltransferase: acyltransferase EO217_RS02435 2-C-methyl-D- dehydrogenase: acyltransferase: peptidase: carboxylate gamma-synthase: 5'-methylthioadenosine/ hydroxyhexanoyl-[acp] 2-deoxy-D-ribose murG a 2-methyl diphosphate a [lipoyl-carrier a (6Z)-3-oxooctadec- menA uracil-DNA 3 EO217_RS11850 lpdA reductase: folate RS12825 folate protein] complex EO217_RS08110 reductase: fabG acyl-ACP threonylcarbamoyl- phosphorylase: 5-phosphate decaprenyl-pyrophosphoryl- acyl-carrier protein branched EO217_RS119151,2-dimyristoyl- PlsY:1-stearoyl- plsY [+ 5 isozymes] erythritol kinase: an N - 1-palmitoyl-2-EO217_RS11915 iadA [cysteine desulfurase]-S- adenosylhomocysteine protein]-N 6 - 6-enoyl-[acp] AMP diphosphate N-acetyl-D- 3-hydroxyacyl- a (3R,9Z)-3- thioesterase: hypoxanthine guanine deoD demethylmenaquinol-4 glycosylase: EO217_RS10945 methyluracil 1498 dihydrolipoamide proC coproporphyrinogen III nucleosidase: AMP synthase: UDP (N-acetylglucosamine)-N- 2,3,4-saturated acyl-carrier protein sn-glycerol acyl-carrier protein sn-glycerol ala 2-phospho-4-(cytidine palmitoleoyl- a peptide asp sulfanylcysteine:[acceptor 5-methyltetrahydropteroyltriglutamate- lipoyl-L-lysine ACP dehydratase EO217_RS13620 muramate Hyp cys hydroxyhexadec- EO217_RS13225 EO217_RS12610 purine-nucleoside deoxyribose- acetylmuramyl-(pentapeptide) fatty acyl-CoA 3-phosphate 3-phosphate 5'-diphospho)-2-C- in 16S rRNA dehydrogenase: sn-glycerol protein]-cysteine EO217_RS07750 (L-threonylcarbamoyl) an apyrimidinic oxygen-independent - homocysteine S- FabZ: fabZ 9-enoyl-[acp] uracil a [lipoyl-carrierEO217_RS07725 + + phosphorylase: phosphate methyl-D-erythritol 3-phosphate adenylate site in DNA 6 Na RS06665 Na sulfurtransferase: methyltransferase: EO217_RS07010 S-ribosyl-L- cis-vaccenate protein]-N - coproporphyrinogen 3-hydroxyacyl- 6 EO217_RS10050 aldolase: deoC EO217_RS07715 L-homocysteine N -L- a [cysteine III oxidase: homocysteine ACP dehydratase lipoyl-L-lysine dihydrofolate threonylcarbamoyladenine desulfurase]-(S- EO217_RS04945 FabZ: fabZ reductase: demethylmenaquinol- acyl-[acyl- synthase: tsaD sulfanyl) -[disordered- tetrahydrofolate biosynthesis a (2E,9Z)-hexadeca- xanthine acetaldehyde D-glyceraldehyde 3-phosphate sulfite RS06825 sulfite 2 EO217_RS02090 9 biosynthesis carrier protein] an N 6 -L- a long-chain 1-palmitoyl- an (R)-2- a 3,5,7,9,11,13,15- guanosine 2251 D-ribulose a 1-acyl-sn form scaffold protoporphyrinogen IX 2,9-dienoyl-[acp] seleno-L- a (7Z)-hexacos- sn-glycerol hydantoin sn-glycerol a (2E)-hex-2-enoyl-[acp] thioesterase pathway 37 superpathway of pyrimidine a malonyl-[acp] 2,3,4-saturated a palmitoyl-[acp] sn-glycerol a myristoyl-[acp] hepta-oxo- -glycerol 3- an arachidoyl-[acp] [+ 2 isozymes] (7,8-dihydropterin- S-ribosylhomocysteine all-trans- threonylcarbamoyladenine halocarboxylate ATP H O in 23S rRNA 5-phosphate 3-phosphate protein] complex serine glycine cleavage 1,4-dihydroxy- enoyl-ACP homocysteine 7-enoyl-[acp] fatty acid HAD family 3-phosphate 2 ribulose-phosphate phosphate 4-aminobenzoate 6-yl)methyl lyase: EO217_RS08115 an acyl-[acyl- in tRNA deoxyribonucleosides degradation beta-ketoacyl- acyl-CoA 1-acyl-sn-glycerol-3-phosphate glycerol-3- hexadecanoyl-[PKS-acp]aldo/keto 23S rRNA 1-acyl-sn-glycerol- glycerol-3- nonaprenyl enoyl-ACP 5-methyltetrahydropteroyltriglutamate- ATPase: hydantoinase: enoyl-ACP asp asp a 7,8-dihydrofolate hydroxymethyltransferase: system aprotein 5-methyltetrahydrofolate H: 2-naphthoate reductase hydrolase: (guanosine(2251) 3-epimerase: phosphate 1-O- dihydropteroatediphosphate diphosphate 1,4-dihydroxy- carrier protein] 2'-deoxycytidine ACP synthase synthetase: 3-phosphate phosphate 1-O- reductase: 3-phosphate EO217_RS12615 EO217_RS07615 reductase FabI: fabI acyl-ACP - homocysteine S- EO217_RS04595 EO217_RS12410 EO217_RS09090 EO217_RS01620 reductase RS01110 synthase: folP urate acetyl-CoA S-methyl-5'-thioadenosine II: fabF EO217_RS03490 acyltransferase: acyltransferase EO217_RS01875 -2'-O)- acyltransferase: acyltransferase 7,8- 2-naphthoate FabI: fabI thioesterase: methyltransferase: EO217_RS07010 a long-chain ATPase: FabI: fabI a [cysteine desulfurase]- protoporphyrin IX degradation IV a (9Z)-3-oxooctacos- EO217_RS11915 [+ 2 isozymes] PlsY: plsY [+ 5 isozymes] methyltransferase ribulose-phosphate EO217_RS11915 PlsY: plsY ala ala dihydropteroate polyprenyltransferase: a palmitoleoyl-[acp] cytidine acyl-carrier protein an (S)-2- 1-myristoyl- 9-hydroxy-3,5,7,11,13,15- a 1-acyl-2- 1-arachidinoyl- thymidylate EO217_RS13225 9-enoyl-[acp] AMP diphosphate 2,3,4-saturated dipalmitoyl EO217_RS00570 RlmB: rlmB N-carbamoylglycine 3-epimerase: a (2E)-icos- sn-glycerol sn-glycerol [scaffold protein- menA a hexanoyl-[acp] deaminase: SeMet acyl-carrier protein a halide anion acyl-carrier protein sn-glycerol hexaoxohexadecanoyl- 2-O- palmitoyl-sn sn-glycerol RS12815 bifunctional folate polyglutamylation a fatty acid S-methyl-5'- fatty acyl CoA hydroxyarboxylate + 2-enoyl-[acp] (2Fe-2S)] complex synthase: phosphatidate H phosphate ADP 2251 EO217_RS11060 3-phosphate 3-phosphate demethylmenaquinol-9 Glycolysis EO217_RS10080 thioadenosine 3-phosphate [PKS-acp] methylguanosine -glycerol 3- 3-phosphate EO217_RS02085 folylpolyglutamate acyl-ACP thymidine 5'-methylthioadenosine/ D-xylulose beta-ketoacyl- in 23S rRNA phosphate synthase/ thioesterase: superpathway of pyrimidine adenosylhomocysteine 5-phosphate a tetrahydrofolate ACP synthase 2'-deoxyuridine pyrimidine- bifunctional a (6S)-5- dihydrofolate protoheme glutathione EO217_RS13225 glycolysis I (from glucose 6-phosphate) ribonucleosides degradation nucleoside nucleosidase: a [co-chaperone]- methylenetetrahydrofolate formyltetrahydrofolate biosynthesis II: fabF synthase: EO217_RS07750 6 [scaffold protein- dehydrogenase/ formate-- serine palmitoleate cytidine phosphorylase: (2E)- an O - 1-palmitoyl- an (S)-2- a [protein] N-terminal- a double-stranded 5-formyltetrahydrofolate EO217_RS13275 bifunctional MTR a [protein]- sn-glycerol 1-(18-hydroxyoleoyl)- a folate 3'-UMP sn-glycerol a 3-oxooctanoyl-[acp] D-glucopyranose 6-phosphate cytidine EO217_RS10090 a (3Z)-dec-3-enoyl-[acp] a malonyl-[acp] methylguanine sn-glycerol a myristoyl-[acp] a palmitoyl-[acp] a lignoceroyl-[acp] (2Fe-2S)] complex methenyltetrahydrofolate cyclo-ligase: tetrahydrofolate hydroxymethyltransferase: folylpolyglutamate hexadecenoate L-cysteine halocarboxylate formyl-L-methionine sn-glycrol 3-phosphate oligonucleotide formate ATP 3-phosphate 7,8-dihydrofolate cys glu acyl-CoA HAD family 3-phosphate peptide bifunctional dihydrofolate multifunctional 2',3'- cyclohydrolase: ligase: EO217_RS12615 deaminase: pyrimidine- beta-ketoacyl- in DNA 3-phosphate 1-acyl-sn-glycerol- glycerol-3- 1-acyl-sn-glycerol- glycerol-3- EO217_RS05240 synthase/ thymine methylated-DNA-- anaerobic enoyl-ACP thioredoxin monoglutamate bifunctional 3-oxooctanoyl- phosphatidylglycerol glucose-6-phosphate EO217_RS10080 nucleoside synthetase: hydrolase: deformylase: 3-phosphate oligoribonuclease/ reductase: cyclic-nucleotide 2'- phosphate 1-O- a 5,10- EO217_RS13965 a 5,10- EO217_RS03225 dihydrofolate ACP synthase [protein]-cysteine S- 3-phosphate phosphate 1-O- pathway glutamate- [acyl-carrier biosynthesis II (non-plastidic) uridine EO217_RS03490 EO217_RS04595 EO217_RS09465 PAP phosphatase EO217_RS02090 phosphodiesterase/ ribonucleoside- reductase a 5,10- synthase: isomerase: phosphorylase: II: fabF methyltransferase: acyltransferase: acyltransferase acyltransferase: acyltransferase a [chaperone-ATP]- methylenetetrahydrofolate methenyltetrahydrofolate -cysteine protein] NrnA: 5'-nucleotidase/ triphosphate FabI: fabI methylenetetrahydrofolate EO217_RS05355 EO217_RS10090 (2E)- a (5Z)-3-oxododec- EO217_RS11915 [+ 2 isozymes] PlsY: plsY peptide EO217_RS11915 [+ 2 isozymes] PlsY: plsY [co-chaperone]- an oxidized a 10- EO217_RS13275 pyrimidine- acyl-carrier protein EO217_RS07655 1-palmitoyl- an (S)-2- 1-palmitoyl- 1-[18-hydroxyoeoyl]-2- reductase: nrdD 1-oleoyl-sn bifunctional ligase GshA/ reductase: fabG DHAP AMP diphosphate 5-enoyl-[acp] a [protein]-S- deformylase: def EO217_RS12950 3'-nucleotidase: a trans-tetracos- formyltetrahydrofolate nucleoside hexadecenoyl-CoA a guanine in DNA acyl-carrier protein 2-myristoyl a halide anion acyl-carrier protein sn-glycerol [18-hydroxy-lioleoyl]-sn a 7,8-dihydrofolate -glycerol 3- [scaffold protein- thioredoxin methylenetetrahydrofolate glutathione bifunctional NAD(P)H- hydroxyarboxylate an N-terminal L- a nucleoside 5'- EO217_RS13005 dATP 2-enoyl-[acp] a 7,8-dihydrofolate a (3R)-3- F6P methyl-L-cysteine formate (2Fe-2S)] complex bifunctional folylpolyglutamate phosphorylase: phosphatidate 3-phosphate -glycerol 3-phosphate phosphate dehydrogenase/ synthetase a tetrahydrofolate dependent glycerol- methionyl-[protein] monophosphate uridine hydroxyoctanoyl-[acp] EO217_RS10090 methenyltetrahydrofolate dihydrofolate GshB: gshAB folylpolyglutamate synthase/ 3-phosphate demethylmenaquinol- γ-L-glutamyl- uracil 2-deoxy-α-D- thioredoxin- reductase: synthase/ dihydrofolate 3-hydroxyacyl- fructose-1,6- cyclohydrolase: dehydrogenase: uracil ribose 1-phosphate 6 biosynthesis I L-cysteine demethylmenaquinol- 6-phosphofructokinase: (R)-4'- 4 disulfide EO217_RS13965 EO217_RS02090 dihydrofolate synthase: ACP dehydratase EO217_RS06235 bisphosphatase: an O - 1-cis-vaccenoyl- an (S)-2- a cytidine 1402 8 biosynthesis I pfkA a [protein]- a cis- an alkylated DNA an unsulfurated a double stranded DNA citrate 3'-cmp sn-glycerol a glutaryl-[acp] a [chaperone- reductase: all-trans- bifunctional synthase: EO217_RS13275 FabZ: fabZ EO217_RS06695 phosphopentomutase: phosphopantothenoyl- a cis-delta9-C28:1-[acp] a malonyl-[acp] methylthymine sn-glycerol- cys 1,4-dihydroxy- a 10- [+ 2 isozymes] L-cysteine halocarboxylate [sulfur carrier] in 16S rRNA formate GTP 3-phosphate an [2Fe-2S] hexaprenyl all-trans- NAD(P)H- deoB L-cysteine vaccenoyl-[acp] HAD family DNA-3- DNA gyrase citrate lyase multifunctional 2',3'- methyl ester ADP]-[disordered- trxB 2-naphthoate glutamate- EO217_RS13275 a 5,10- 1,4-dihydroxy- 3-hydroxyacyl- beta-ketoacyl- in DNA 1-acyl-sn-glycerol-3-phosphate cysteine 16S rRNA glycerol-3- cluster protein formyltetrahydrofolate dependent glycerol- methylated-DNA-- anaerobic enoyl-ACP form scaffold diphosphate1,4-dihydroxy- a tetrahydrofolate -cysteine octaprenyl 2-deoxy-D-ribose hydrolase: methyladenine (cytidine(1402)-2'-O) subunit A: gyrA subunit cyclic-nucleotide 2'- phosphate 1-O- a 10- methylenetetrahydrofolate 2-naphthoate ACP dehydratase DHAP β-D-fructose 1,6-bisphosphate 5,6-dihydrouracil phosphopantothenoylcysteine ACP synthase [protein]-cysteine S- 3-phosphate desulfurase: protein] complex 2-naphthoate ligase GshA/ diphosphate1,4-dihydroxy- 3-phosphate EO217_RS04595 glycosylase: -methyltransferase: alpha: citF phosphodiesterase/ ribonucleoside- reductase formyltetrahydrofolate FabZ: fabZ 5-phosphate decarboxylase: coaC II: fabF methyltransferase: acyltransferase: EO217_RS13255 type I DNA acyltransferase polyprenyltransferase: 2-naphthoate dehydrogenase: EO217_RS11835 5'-nucleotidase/ triphosphate FabI: fabI a reduced glutathione fructose-bisphosphate a cis-delta11-3- EO217_RS11915 [+ 2 isozymes] [+ 2 isozymes] rsmI topoisomerase: [+ 5 isozymes] PlsY: plsY EO217_RS12880 hydantoinase: acyl-carrier protein EO217_RS07655 1,2-dicis- a (2R)-2- a DNA containing a 2'-O- reductase: nrdD 1-palmitoyl- thioredoxin menA synthetase polyprenyltransferase: a (2E)-oct-2-enoyl-[acp] 4'-phosphopantetheine oxo-C30:1-[acp] a [protein]-S- an alkylated a sulfurated 1402 topA 3'-nucleotidase: an enoylglutaryl- sn-glycerol triose-phosphate aldolase: EO217_RS09090 deoxyribose- a thymine in DNA acyl-carrier protein vaccenoyl- a halide anion an apurinic/ ala methylcytidine oxaloacetate acetate sn-glycerol demethylmenaquinol-6 GshB: gshAB menA methyl-L-cysteine hydroxy fatty acid nucleobase a negatively EO217_RS13005 dGTP [acp] methyl ester isomerase: EO217_RS13385 phosphate apyrimidinic site [sulfur carrier] in 16S rRNA 3-phosphate an [Fe-S cluster demethylmenaquinol-8 3-phosphate phosphatidate supercoiled DNA enoyl-ACP EO217_RS06510 Fermentation 3-ureidopropanoate aldolase: purine ribonucleosides degradation cytidine biosynthesis glutathione glycerol-3- reductase deoC chaperone]-ATP phosphate 1-O- FabI: fabI pyruvate acyltransferase 1-palmitoyl- an (R)-2- a cytidine 1402 a [release factor]- methyl β-D-glucoside D-glyceraldehyde 3-phosphate fermentation D-glyceraldehyde adenosine phosphatidylglycerolphosphate a cis,cis-delta19- pentadecanoate a cis- oleate DNA with lesion a (5Z)-dodec- acetaldehyde a malonyl-[acp] sn-glycerol MEP CTP an acyl phosphate gln an octanoyl-[acp] PlsY: plsY 3-phosphate (1-oleoyl, 2-palmitoyl) halocarboxylate in 16S rRNA L-glutamine 6-phosphate to (R)-acetoin II 37-C56:2-[acp] acyl-CoA vaccenoyl-[acp] HAD family acyl-CoA excinuclease 5-enoyl-[acp] a 1-acyl-sn beta-ketoacyl- 1-acyl-sn-glycerol-3-phosphate 2-C-methyl-D- 16S rRNA peptide chain 6-phospho- glyceraldehyde- β-alanine adenosine amino acid enoyl-ACP beta-ketoacyl- -glycerol 3- pyruvate phosphatidylglycerophosphatase synthetase: hydrolase: synthetase: erythritol 4-phosphate (cytosine(1402)-N(4) release factor acylphosphatase: beta- ABC: uvrA uvrB Amino Acid Biosynthesis deaminase: ACP synthase 3-phosphate 3-phosphate EO217_RS03490 EO217_RS04595 EO217_RS03490 racemase: reductase ACP synthase phosphate acetolactate A: EO217_RS13025 II: fabF acyltransferase: cytidylyltransferase: )-methyltransferase N(5)-glutamine EO217_RS05930 glucosidase: excinuclease dehydrogenase: gap EO217_RS04950 EO217_RS04890 FabI: fabI II: fabF 1-acyl-sn-glycerol- synthase a cis,cis-delta21,39- [+ 2 isozymes] EO217_RS14290 4 RsmH: rsmH methyltransferase: ascB ABC subunit 1-oleoyl-2-palmitoyl- acyl-carrier protein pentadecanoyl- EO217_RS119151-palmitoyl-2- 4-(cytidine 5'- an N - L-lysine biosynthesis II 3-phosphate acetyl-CoA AMP diphosphate a (2R)-2- diphosphate AMP oleoyl-CoA a carboxylate a (3E,5Z)-dodeca- L-proline L-homoserine uracil degradation L-glutamate Aminoacyl-tRNA Charging AlsS: alsS 3-oxo-C58:2-[acp] CoA a halide anion 1402 prmC [+ 2 isozymes] UvrC: uvrC xanthosine adenosine inosine guanosine phosphatidylglycerol acyl-carrier protein cis-vaccenoyl hydroxy fatty acid diphospho)-2-C- methylcytidine 5 D-glutamine biosynthesis I biosynthesis a 3-oxodecanoyl-[acp] acyltransferase: 13-DPG (S)-2-acetolactate a [release factor]-N β-D-glucose DNA without 3,5-dienoyl-[acp] I (reductive) biosynthesis III phosphatidate methyl-D-erythritol in 16S rRNA MeOH EO217_RS11915 UTP and CTP dephosphorylation I -methyl-L-glutamine 6-phosphate lesion asp (from L-glutamate) tRNA charging uracil L-asparagine biosynthesis 3-oxodecanoyl- a 1,2-diacyl- acetolactate asp 2-oxoglutarate aspartate kinase: glu III (tRNA-dependent) [acyl-carrier sn-glycerol decarboxylase: UTP purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside NADP-specific phosphoglycerate all-trans- a 1-alkyl-sn EO217_RS08055 aspartate kinase: arginine-- protein] 3-phosphate budA phosphorylase: phosphorylase: phosphorylase: phosphorylase: 1,4-dihydroxy- a DNA methyl a [protein]- a ribonucleoside 1-cis-vaccenoyl-sn- sn-glycerol glutamate 5- glutamate arg kinase: EO217_RS06515 a cis,cis-delta17,35- linoleate methyl red H O diphosphate formate -glycerol 3- a pimeloyl-[acp] tRNA ligase: CTP synthase: an N-formyl-L-methionylaminoacyl-tRNA a malonyl-[acp] undecaprenyl 2 L-ornithine L-aspartyl- EO217_RS08055 5,6-dihydrouracil reductase: fabG phosphatidate deoD EO217_RS10050 EO217_RS10050 EO217_RS10050 C54:2-[acp] 2-naphthoate phosphotriester L-cysteine triphosphate glycerol-3-phosphate biotin ATP 3-phosphate methyl ester kinase: proB dehydrogenase: asp (R)-acetoin diphosphate acyl-CoA methylated-DNA-- FMN-dependent phosphate 4-phosphate γ-L-glutamyl L-aspartyl- EO217_RS05145 an L-arginyl- cytidylyltransferase: EO217_RS13375 peptide deformylase: beta-ketoacyl- 1,4-dihydroxy- manganese- anaerobic 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- glycerol-3- EO217_RS05360 purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside amino acid enoyl-ACP Arg a (3R)-3- synthetase: [protein]-cysteine S- NADH- 3-phosphate biotin--[acetyl-CoA- phosphate 1-O- 5-phosphate 4-phosphate hydantoinase: [tRNA ] EO217_RS05095 3-phospho-D-glycerate UDP EO217_RS09465 ACP synthase 2-naphthoate dependent inorganic ribonucleoside- 3-phosphate aspartate- hydroxydecanoyl-[acp] phosphorylase: phosphorylase: phosphorylase: phosphorylase: EO217_RS03490 carboxylase] ligase: racemase: reductase glu a tRNA Arg CTP II: fabF methyltransferase: azoreductase: pyrophosphatase: triphosphate acyltransferase: acyltransferase: acyltransferase glutamate-5- EO217_RS09090 a CDP- EO217_RS10050 deoD deoD deoD peptide deformylase: def polyprenyltransferase: EO217_RS04890 FabI: fabI semialdehyde aspartate- a cis,cis-delta19,37- EO217_RS07655 EO217_RS12460 EO217_RS11915 EO217_RS10510 PlsY: plsY gln 3-hydroxyacyl- diacylglycerol formate a L-methionylaminoacyl-tRNA acyl-carrier protein menA EO217_RS02230 reductase: nrdD 1-cis-vaccenoyl- biotinyl-5'- a 2-acyl-1-alkyl-EO217_RS11915 1-C16:0-α,ω- dehydrogenase: semialdehyde semialdehyde 2,3-diphosphoglycerate- AMP diphosphate linoleoyl-CoA a [protein]-S- N,N-dimethyl-1,4- a 2'-deoxyribonucleoside an enoylpimeloyl- 3-ureidopropanoate L-aspartate ACP dehydratase 3-oxo-C56:2-[acp] [DNA] anthranilate + adenylate dehydrogenase: an L-aspartyl- CDP-diacylglycerol-- α-D-ribose- DMKH2-11 methyl-L-cysteine phenylenediamine phosphate H 2-palmitoleoyl-sn- sn-glycerol dicarboxyl-2- D-ornithine EO217_RS08060 dehydrogenase: biosynthesis dependent UMP 5'-triphosphate [acp] methyl ester glycine biosynthesis II Asn carbamoyl- FabZ: fabZ glycerol-3-phosphate 3-phosphate lysophosphatidate EO217_RS10820 EO217_RS08060 [tRNA ] glycerol-3-phosphate 3- phosphoglycerate CDP 1-phosphate L-aspartate 4- phosphate cysteine-- 3-hydroxyacyl- phosphatidyltransferase: multifunctional 2',3'- thymine degradation L-glutamate-5- oxaloacetate cys Asp-tRNA(Asn) mutase: gpmA phosphopentomutase: semialdehyde L-aspartate 4- a [glycine- synthase ACP dehydratase tRNA ligase: pgsA cyclic-nucleotide 2'- all-trans- 3 a 1-acyl-2- γ-L-glutamyl-(S)- semialdehyde semialdehyde bifunctional cleavage complex /Glu-tRNA(Gln) large deoB 1,4-dihydroxy- α,ω-9Z- an N -methyladenine a 2'- an L-glutamyl- 4-hydroxy- gly EO217_RS10855 FabZ: fabZ 1-(3-sn- phosphodiesterase/ thymine a (7Z)-hexadec- a cis,cis-delta15,33- 3'-dephospho- a RNA-DNA hybrid 6 an L-cysteinyl- a malonyl-[acp] a malonyl-[acp] dodecaprenyl arachidonoyl- deoxyribonucleoside trans-1-propenyl- Gln an L-amino acid pro an octanoyl-[acp] β-alanine aspartate H protein] N - amidotransferase: subunit: carB 2-phospho-D-glycerate D-ribose 5- 7-enoyl-[acp] C52:2-[acp] 2-naphthoate octadecenedioate in DNA CTP ATP [tRNA ] tetrahydrodipicolinate glycine cleavage Cys phosphatidyl) CMP 5'-nucleotidase/ diphosphate acyl-CoA DNA-3- CoA ribonuclease HII: deoxynucleoside L-cysteine transaminase/ [tRNA ] gatB gatA gatC beta-ketoacyl- beta-ketoacyl- 1,4-dihydroxy- sn-glycerol glutamyl Asp-tRNA(Asn) lipoyl-L-lysine Cys [+ 5 isozymes] a (2E)-dec-2-enoyl-[acp] phosphate dephospho- amino acid amino acid enoyl-ACP synthase: system protein H: a tRNA a 4-phosphooxy- -sn-glycerol 3'-nucleotidase: synthetase: methyladenine 3-phosphatephosphatidate EO217_RS02155 kinase: aspartate 4- a [glycine-cleavage multifunctional 2',3'- 5,6-dihydrothymine ACP synthase ACP synthase 2-naphthoate aminopeptidase: /Glu-tRNA(Gln) EO217_RS08075 EO217_RS07615 3-phosphate phosphopyruvate EO217_RS13005 EO217_RS03490 CoA kinase: EO217_RS07375 racemase: racemase: reductase decarboxylase: complex H protein] N 6 - L-aspartyl- cyclic-nucleotide 2'- II: fabF II: fabF glycosylase I: cytidylyltransferase: ribonuclease HIII: pepA amidotransferase: (2S,4S)-4- (S)-1-pyrroline- ammonium enoyl-ACP hydratase: polyprenyltransferase: ω EO217_RS04520 S-trans-1- EO217_RS04890 EO217_RS04890 FabI: fabI [tRNA Asn ] phosphatidylglycerophosphatase hydantoinase: a (9Z)-3-oxo- a cis,cis-delta17,35- -carboxy- EO217_RS05680 a CDP-1-acyl-EO217_RS05095 EO217_RS06735 [+ 2 isozymes] hydroxy-2,3,4,5- 5-carboxylate L-homoserine EO217_RS01115 aminomethyldihydrolipoyl- reductase phosphodiesterase/ uridine acyl-carrier protein acyl-carrier protein menA + a 2'- propenyl- glu gatB gatA gatC EO217_RS06505 EO217_RS09090 octadec-9-enoyl-[acp] 3-oxo-C54:2-[acp] AMP diphosphate (9Z)-octadec- an apurinic site 2-arachidonoyl- ADP coenzyme A H a nucleoside 5'- an L-glutaminyl- a (2E)-oct- L-lysine A: EO217_RS13025 5'-nucleotidase/ 3-methyladenine DNA deoxyribonucleoside a D-amino acid D-proline tetrahydrodipicolinate pyrroline-5- superpathway of L- asp FabI: fabI DMK-12 within DNA L-cysteine Gln Asp-tRNA(Asn) an L-1- 9-enoyl-CoA glycerol monophosphate [tRNA ] 2-enoyl-[acp] 4-hydroxy- carboxylate asparagine biosynthesis 3'-nucleotidase: 3-(carbamoylamino)- 5'-monophosphate gln /Glu-tRNA(Gln) phosphatidyl- phosphoenolpyruvate tetrahydrodipicolinate reductase: a decanoyl-[acp] EO217_RS13005 2-methylpropanoate Secondary Metabolite Degradation amidotransferase: sn-glycerol reductase: proC an L-glutaminyl- 1-palmitoyl- asp gatB gatA gatC cytidine an all-trans- D-glyceraldehyde a [protein]- a guanine 527 3-octaprenyl-4- glycine biosynthesis I [tRNA Gln ] beta-ketoacyl- a cis,cis-delta13,31- 1,4-dihydroxy- octanoate carbamoyl pyruvate FAD (R)-mevalonate EO217_RS08070 anhydromuropeptides recycling I a cis-delta17-C36:1-[acp] a malonyl-[acp] a malonyl-[acp] polyisoprenyl L-ornithine 3-phosphate sn-glycerol a protein leu a cerotoyl-[acp] a tRNA Gln ACP synthase pyruvate kinase: pyk superpathway of β-D- fructosyllysine and C50:2-[acp] 2-naphthoate phosphate L-threonine diphosphate in 16S rRNA hydroxybenzoate (S)-2,3,4,5- pro diphosphate acyl-CoA 1-deoxy-D-xylulose- FAD:protein FMN 16S rRNA 3-phosphate alanine an L-asparaginyl- II: fabF (R)-3-amino-2- GlcNAc-1,6- glucuronosides degradation glucosyllysine metabolism beta-ketoacyl- beta-ketoacyl- 1,4-dihydroxy- putrescine UbiD family 1-acyl-sn-glycerol- tetrahydrodipicolinate asparagine asparagine synthetase: 5-phosphate transferase: (guanine(527)-N(7) amino acid enoyl-ACP Asn ACP synthase ACP synthase carbamoyltransferase: diphosphomevalonate decarboxylase: 3-phosphate Clp protease ClpP: racemization ser [tRNA ] methylpropanoate anhMurNAc- aldehydo- 2-naphthoate racemase: reductase synthase synthase stearate biosynthesis β keto-D-fructose EO217_RS03490 synthase: EO217_RS10470 decarboxylase: mvaD )-methyltransferase 2,3,4,5- serine a 3-oxododecanoyl-[acp] L-Ala-γ-D-Glu- a -D-glucuronoside D-glucose II: fabF II: fabF polyprenyltransferase: EO217_RS13090 EO217_RS08335 acyltransferase: EO217_RS04300 (glutamine- (glutamine- II (bacteria and plants) pyruvate a cis-delta19-3- a cis,cis-delta15,33- EO217_RS03775 RsmG: rsmG EO217_RS04890 FabI: fabI tetrahydropyridine- hydroxymethyltransferase: DAP-D-Ala acyl-carrier protein acyl-carrier protein menA L-citrulline a [protein]-FMN- an N 7 - a 1-palmitoyl-2-EO217_RS11915 hydrolyzing) hydrolyzing) ala diphosphate AMP octanoyl-CoA 1-deoxy-D-xylulose AMP 2-octaprenylphenol a trans-hexacos- 2,6-dicarboxylate N- glutamate-- 3-oxododecanoyl- oxo-C38:1-[acp] 3-oxo-C52:2-[acp] IPP 527 EO217_RS12615 glu DMKH 5-phosphate L-threonine methylguanine acyl-sn-glycerol a peptide D-leucine : asnB : asnB alanine racemase: tRNA ligase: 2 2-enoyl-[acp] acetyltransferase: gly [acyl-carrier a palmitoyl-[acp] D-glucopyranuronate in 16S rRNA 3-phosphate L-phenylalanine EO217_RS09350 gln Detoxification N-acetylmuramoyl- dapD EO217_RS10845 an L-glutamyl- glutaminyl-tRNA protein] 3-oxo- 6 6 biosynthesis I L-alanine amidase: N -(D-fructosyl) N -(D-glucosyl) amino acid Glu biosynthesis via transamidation stearoyl-[acp] Respiration [tRNA ] reductase: fabG EO217_RS02435 -L-lysine -L-lysine L-2-acetamido-6- asn asn racemase: glu reactive oxygen species degradation all-trans- 7,8-dihydrofolate Man GlcNAc - 966 1-myristoyl- a tRNA synthase: fabF superoxide 1,4-dihydroxy- + 9 2 maltotriose a guanine adenosyl-cob(III) oxoheptanedioate chorismate a (3R)-3- a 3-oxooctadecanoyl- arsenate [+ 5 isozymes] a cis,cis-delta11,29- NADPH H dihydrolipoamide a supercoiled duplex DNA sn-glycerol EO217_RS04890 a cis-delta15-C34:1-[acp] a malonyl-[acp] a malonyl-[acp] tridecaprenyl monoglutamate [protein] (isomer in 16S rRNA yrinate a,c-diamide asn a dodecanoyl-[acp] a decanoyl-[acp] glu 2-oxoglutarate decarboxylation to succinyl-CoA radicals degradation C48:2-[acp] 2-naphthoate alpha-glucosidase: chorismate mutase: D-ala hydroxydodecanoyl-[acp] [acp] detoxification aldehydo-D-glucuronate diphosphate dihydrofolate 9A B ) dihydrolipoyllysine- helicase DnaB: 16S rRNA 3-phosphate superoxide N-acetyl-β-D- L-alanyl-γ-D- beta-ketoacyl- beta-ketoacyl- 1,4-dihydroxy- 1,2,3 1,2,3alpha-1,2- adenosylcobyric 1-acyl-sn-glycerol- EO217_RS09480 II (glutaredoxin) reductase: EO217_RS03510 residue EO217_RS04505 (guanine(966)-N(2) amino acid enoyl-ACP enoyl-ACP 3-hydroxyacyl- (R)-3- a [2-oxoglutarate glucuronate 6 6 ACP synthase ACP synthase mannosidase: acid synthase: 3-phosphate superoxide glucosamine-1,6- glutamyl-meso-2,6- N -(6-phospho- N -(6-phospho- 2-naphthoate racemase: reductase reductase prephenate superoxide EO217_RS05675 alpha-glucosidase: acetyltransferase: replicative DNA )-methyltransferase ACP dehydratase hydroxystearoyl- dehydrogenase arsenate superoxide anhydro-N-acetyl- diaminopimeloyl- isomerase: D-fructosyl) D-glucosyl) II: fabF II: fabF polyprenyltransferase: EO217_RS11525Man GlcNAc - EO217_RS12545 acyltransferase: isoleucine- gln β-D- 8 2 EO217_RS08640 EO217_RS04890 FabI: fabI FabI: fabI N-acetyl-L,L-2,6- ile FabZ: fabZ [acp] E2 protein] N 6 dismutase: arsenate dismutase: uxaC a cis-delta17-3- a cis,cis-delta13,31- [+ 2 isozymes] EO217_RS02610 helicase: dnaB 2 RsmD: rsmD EO217_RS11915 prephenate L-tyrosine -tRNA β-D-muramate D-alanine -L-lysine -L-lysine acyl-carrier protein acyl-carrier protein menA 5,6,7,8- [protein] (isomer an N - 1,2-dimyristoyl- diaminopimelate dihydrolipoamide EO217_RS14390 oxo-C36:1-[acp] 3-oxo-C50:2-[acp] + mannopyranose adenosylcobyrate a (2E)-dodec- a (2E)-dec- an L-glutamyl- 3-hydroxyacyl- reductase: fabG -lipoyl-L-lysine reductase: EO217_RS14390 NADP 8A B ) D-glucopyranose maltose S-acetyldihydrolipoamide a single stranded DNA methylguanine 966 sn-glycerol D-asparagine dehydratase: biosynthesis I ligase: ileS DMKH2-13 tetrahydrofolate 1,2,3 2,3 an L-isoleucyl- Gln carbamoyl- a (3R)-3- dehydrogenase: hydrogen D-fructuronate 2-enoyl-[acp] 2-enoyl-[acp] N-acetyl- [tRNA ] ACP dehydratase dihydrolipoamide hydrogen EO217_RS08150 in 16S rRNA 3-phosphate pheA Ile peroxide diaminopimelate [tRNA ] phosphate hydroxyoctadecanoyl- EO217_RS07725 peroxide arsenite L-alanine Ile FabZ: fabZ dehydrogenase: mannonate 3-phenyl-2- chorismate L-cysteine a tRNA Asp-tRNA(Asn) synthase [acp] L-alanyl-γ-D- deacetylase: biosynthesis III EO217_RS07725 catalase: 1,6-anhydro-N- oxidoreductase: oxopropanoate chorismate mutase: biosynthesis I /Glu-tRNA(Gln) large 3-hydroxyacyl- glutamyl-meso- all-trans- α-maltose 6'- Man GlcNAc - (R)-5- β-D-fructofuranose 1-palmitoyl- EO217_RS08050 a (2E)-dodec-2-enoyl-[acp] catalase: ade acetyl-β-muramate lys a cis,cis-delta9,27- 1,4-dihydroxy- 8 2 a petroselinoyl- an L-cysteinyl- a nucleoside EO217_RS09480 amidotransferase: dihydrolipoyl EO217_RS08570 decaprenyl [protein] (isomer sn-glycerol phosphoenol bifunctional subunit: carB ACP ade diaminopimelate a cis-delta19-C38:1-[acp] a malonyl-[acp] a malonyl-[acp] phosphate phosphomevalonate 1-phosphate Cys a behenoyl-[acp] dehydrogenase: C46:2-[acp] 2-naphthoate [acp] GTP H O [tRNA ] diphosphate dADP L,L- prephenate cys gatB gatA gatC dehydratase diphosphate maltose-6'- 8A B ) fructose- 2 3-phosphate pyruvate aspartate ser [+ 5 isozymes] enoyl-ACP O D-mannonate beta-ketoacyl- beta-ketoacyl- 1,4-dihydroxy- 1,2,3 alpha-1,2-2,3 acyl-ACP phosphomevalonate aminoacyl-tRNA 1-acyl-sn-glycerol- nucleoside- cysteine a 5-phosphooxy- lpdA a [2-oxoglutarate a [2-oxoglutarate 2 GTPase enoyl-ACP diaminopimelate FabZ: fabZ H O hydroxyl radical arsenite phosphate mannosidase: kinase: bisphosphate diphosphate pyruvate transaminase/ serine O- leucine-- reductase dehydrogenase dehydrogenase 2 ACP synthase ACP synthase 2-naphthoate thioesterase: hydrolase: 3-phosphate prephenate desulfurase: leu L-glutamyl- O N-acetyl-D- mannonate ObgE: obgE reductase ammonium 6 6 2 glucosidase: EO217_RS11525 EO217_RS09140 aldolase: kinase: kinase: pyk diaminopimelate aspartate 4- acetyltransferase: tRNA ligase: Gln FabI: fabI 3-hydroxyacyl- E2 protein] N E2 protein] N -S- II: fabF II: fabF polyprenyltransferase: Man GlcNAc - EO217_RS13225 EO217_RS11110 acyltransferase: dehydrogenase: EO217_RS07585 [tRNA ] muramate 6- dehydratase: a cis-delta21-3- a cis,cis-delta11,29- EO217_RS01510 β-D- 7 2 EO217_RS13385 [+ 3 isozymes] FabI: fabI epimerase: dapF decarboxylase: cysE EO217_RS11365 an L-leucyl- ACP -dihydrolipoyl- succinyldihydrolipoyl- acyl-carrier protein acyl-carrier protein menA [protein] (isomer acyl-carrier protein petroselinate (R)-mevalonate a tRNA Cys cys 1-palmitoyl-EO217_RS11915 EO217_RS07325 EO217_RS04670 [+ 2 isozymes] phosphate uxuA oxo-C40:1-[acp] 3-oxo-C48:2-[acp] D-glucopyranose mannopyranose phosphate GDP H + a nucleoside dATP pyruvate a (2E)-docos- EO217_RS01115 O-acetyl-L-serine [tRNA Leu ] a dodecanoyl-[acp] dehydratase L-lysine L-lysine DMKH2-10 D-glucopyranose 7A B ) diphosphate D-glyceraldehyde DHAP 2-myristoyl 3-(4- ala Asp-tRNA(Asn) N-acetylmuramic L-idonate 6-phosphate 1,2,3 2 triphosphate 2-enoyl-[acp] meso- a tRNA Leu FabZ: fabZ mannonate phosphatidate hydroxyphenyl) /Glu-tRNA(Gln) acid 6- degradation diaminopimelate phe cysteine dehydratase: pyruvate amidotransferase: beta-ketoacyl- acyl-ACP a (2E)-octadec- Alcohol Degradation phosphate synthase A: cysK uxuA gatB gatA gatC 2-enoyl-[acp] etherase: murQ L-idonate Man GlcNAc - 967 1-palmitoyl- diaminopimelate ACP synthase thioesterase: dihydrolipoamide α 7 2 a long-chain a cytosine an insertion sequence a [protein] with a (2E,7Z)- N-acetyl-D- 2-dehydro-3- a cis,cis-delta17,29- F6P a 1,4- -D-glucan a peptide with a decarboxylase: lysA II: fabF EO217_RS13225 dehydrogenase: a cis-delta11-C30:1-[acp] a malonyl-[acp] a malonyl-[acp] protein (isomer acyl-[acyl- an N-terminal sn-glycerol tyr phosphoenol hexadeca-2,7- enoyl-ACP glycerol and glycerophosphodiester degradation deoxy-D-gluconate C48:2-[acp] leader sequence in 16S rRNA element IS30 dGDP cys ethylene glycol glucosamine fructose-6- alpha-glucosidase: 7A B ) 16S rRNA 3-phosphate pyruvate an L-glutaminyl- reductase EO217_RS07725 beta-ketoacyl- beta-ketoacyl- 1,2,3 alpha-1,2-1 carrier protein]acyl-ACP signal transposase: L-glutamateglutamyl 1-acyl-sn-glycerol- dienoyl-[acp] val 2-dehydro-3- 5-dehydro- EO217_RS03510 tyrosine enoyl-ACP valine--tRNA ligase: [tRNA Gln ] degradation 6-phosphate phosphate (cytosine(967)-C(5) pyruvate lys tyr FabI: fabI ACP synthase ACP synthase mannosidase: thioesterase: peptidase I: lepB EO217_RS11420 aminopeptidase: 3-phosphate decarboxylase: tdc laurate a glycerophosphodiester N-acetylglucosamine- deoxygluconokinase: D-gluconate aldolase: alpha-glucosidase: )-methyltransferase reductase EO217_RS13270 an L-valyl- a 3-oxotetradecanoyl-[acp] II: fabF II: fabF EO217_RS11525Man GlcNAc - EO217_RS13225 [+ 2 isozymes] [+ 4 isozymes] pepA acyltransferase: kinase: pyk 6-phosphate EO217_RS09160 β 6 2 tyrosine FabI: fabI [tRNA Val ] a stearoyl-[acp] ethylene glycol gluconate 5- a cis-delta13-3- a cis,cis-delta19,31- EO217_RS04035 EO217_RS08640 -D- a long-chain RsmB: rsmB an insertion acyl-CoA acyl-carrier protein acyl-carrier protein [protein] (isomer acyl-carrier protein a leader sequence a peptide 967 a peptide glu 1-palmitoyl-2-EO217_RS11915 decarboxylase: tdc Val 3-oxotetradecanoyl- lactaldehyde deacetylase: nagA dehydrogenase: oxo-C32:1-[acp] 3-oxo-C50:2-[acp] D-glyceraldehyde α mannopyranose fatty acid a 5-methylcytosine sequence IS30 with dGTP pyruvate a (7Z)-hexadec- a tRNA synthetase: dihydroxyacetone D-glucopyranose a 1,4- -D-glucan 6A B ) cis-vaccenoyl glycerophosphoryl KDGP 3-phosphate 1,2 1 in 16S rRNA tyramine [acyl-carrier protein] acyl-ACP reductase: fucO D-glucosamine EO217_RS09150 integrated transposon 7-enoyl-[acp] EO217_RS03490 diester phosphatidate reductase: fabG thioesterase: glycolaldehyde 6-phosphate phosphodiesterase: glycerol bifunctional D-gluconate a (3R)-3- lauroyl-CoA EO217_RS13225 phosphoglucosamine EO217_RS05330 4-hydroxy-2- Man GlcNAc - Cell Structure Biosynthesis mutase: gluconokinase: 8 2 a single 3-phospho- a monocarboxylic a [protein]- alanine- hydroxytetradecanoyl-[acp] a cis,cis-delta13,25- a cis,cis-delta5,23- maltohexaose an N-modified agmatine stearate glycerophosphodiester glycerol oxoglutarate a cis-delta13-C32:1-[acp] a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] [protein] (isomer leu val a hexanoyl-[acp] -tRNA EO217_RS04835 EO217_RS10615 C44:2-[acp] C42:2-[acp] stranded DNA aminoacyl-[tRNA] D-glycerate acid amide L-tyrosine ala 3-hydroxyacyl- phosphodiesterase: kinase aldolase/2- alpha-glucosidase: 8A B ) D-3- agmatine β ligase: α-D-glucosamine beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- 1,2,3 alpha-1,2-1,2 aminoacyl-tRNA branched-chain branched-chain tyrosine peptidoglycan biosynthesis V ( -lactam resistance) ACP dehydratase acyl-CoA EO217_RS13340 GlpK: glpK glycolate dehydro-3-deoxy- D-gluconate EO217_RS03510 deoxyribonuclease deiminase: aguA amidase: enoyl-ACP ACP synthase ACP synthase ACP synthase mannosidase: hydrolase: phosphoglycerate protein kinase: peptidoglycan biosynthesis IV (Enterococcus faecium) alaS an L-alanyl- synthetase: 1-phosphate 6-phosphate amino acid amino acid reductase FabZ: fabZ phosphogluconate alpha-glucosidase: IV: EO217_RS06195 dehydrogenase: agmatine EO217_RS03620 α Ala II: fabF II: fabF II: fabF EO217_RS11525Man GlcNAc - EO217_RS11110 aminotransferase: aminotransferase: EO217_RS06035 UDP-N-acetyl- -D-glucosamine [tRNA ] EO217_RS03490 7 2 FabI: fabI 3-hydroxyacyl- phosphatidylglycerol sn-glycerol bifunctional UDP-N- aldolase: a cis-delta15-3- a cis,cis-delta15,27- a cis,cis-delta7,25- EO217_RS08640 β-D- an N-modified an uncharged EO217_RS12425 deiminase: aguA a [protein]- UDP-N-acetyl-α-D-glucosamine a tRNA Ala acyl-carrier protein acyl-carrier protein acyl-carrier protein [protein] (isomer EO217_RS02970 EO217_RS02970 UDP-N-acetylglucosamine biosynthesis I (plastidic) acetylglucosamine EO217_RS09165 oxo-C34:1-[acp] 3-oxo-C46:2-[acp] 3-oxo-C44:2-[acp] mannopyranose a 5'-phosphooligonucleotide amino acid tRNA a monocarboxylate 4-methyl-2- 3-methyl-2- L-tyrosine a (2E)-hex- ACP dehydratase stearoyl-CoA 3-phosphate D-glucopyranose maltopentaose 7A B ) 3-phosphooxypyruvate N-carbamoylputrescine 1-carboxyvinyltransferase: UDP-N-acetylglucosamine FabZ: fabZ diphosphorylase/ D-glyceraldehyde 1,2 1,2 oxopentanoate oxobutanoate phosphate 2-enoyl-[acp] pyruvate murA 1-carboxyvinyltransferase: DHAP glucosamine-1- 3-phosphate mannitol murA phosphate N- UDP-N-acetylglucosamine a (2E)-tetradec-2-enoyl-[acp] NAD(P)H- degradation I Man GlcNAc - UDP-N-acetylglucosamine asparagine- dependent glycerol- acetyltransferase 7 2 D-sedoheptulose a negatively 1-carboxyvinyltransferase: asn DHAP D-mannitol a (5Z)-tetracos- a cis,cis-delta11,23- a cis,cis-delta3,21- maltoheptaose O-succinyl-L- an aldehyde (S)-lactate -tRNA enoyl-ACP 3-phosphate GlmU: glmU a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] [protein] (isomer a myristoyl-[acp] 1-phosphate ile supercoiled DNA a palmitoyl-[acp] EO217_RS13390 1-carboxyvinyltransferase: 5-enoyl-[acp] C42:2-[acp] C40:2-[acp] homoserine NaMN ATP fatty acid elongation -- saturated α 1-phosphate alpha-glucosidase: 7A B ) fructose- type I DNA L-lactate oxidase: EO217_RS13390 ligase: asnS an L-asparaginyl- reductase dehydrogenase: N-acetyl- -D- mannitol-1- beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- 1,2 1,2alpha-1,2- acyl-ACP cystathionine zinc-binding alcohol branched-chain UDP-N-acetyl-α-D- EO217_RS03510 enoyl-ACP Asn FabI: fabI EO217_RS06235 glucosamine D-galacturonate degradation I ACP synthase ACP synthase ACP synthase mannosidase: thioesterase: gamma-synthase: nicotinate-nucleotide bisphosphate dehydrogenase: topoisomerase: EO217_RS06800 glucosamine-enolpyruvate UDP-N-acetyl-α-D- [tRNA ] phosphate 5- amino acid Asn alpha-glucosidase: adenylyltransferase: aldolase: topA L-lactate oxidase: reductase glucosamine-enolpyruvate tRNA NAD(P)H- 1-phosphate dehydrogenase: II: fabF II: fabF II: fabF EO217_RS11525Man GlcNAc - EO217_RS13225 EO217_RS08110 EO217_RS10575 aminotransferase: UDP-N-acetylmuramate a myristoyl-[acp] an acetoacetyl-[acp] aldehydo-D- a (7Z)-3-oxohexacos- a cis,cis-delta13,25- a cis,cis-delta5,23- EO217_RS08640 β-D- 6 2 EO217_RS14585 EO217_RS13385 [+ 3 isozymes] EO217_RS12080 FabI: fabI dependent glycerol- bifunctional UDP-N- EO217_RS01630 acyl-carrier protein acyl-carrier protein acyl-carrier protein [protein] (isomer myristate acyl-carrier protein succinate L-homocysteine nicotinate adenine EO217_RS02970 dehydrogenase: murB UDP-N-acetylmuramate galacturonate 7-enoyl-[acp] 3-oxo-C44:2-[acp] 3-oxo-C42:2-[acp] mannopyranose an alcohol (S)-3-methyl-2- a (2E)-hexadec- glu D-glucopyranose maltohexaose 6A B ) dinucleotide D-erythrose DHAP a relaxed DNA pyruvate dehydrogenase: murB 3-phosphate acetylglucosamine glucuronate mannitol-1- 1,2 2 glu beta-ketoacyl- oxopentanoate 2-enoyl-[acp] dehydrogenase: diphosphorylase/ isomerase: phosphate 5- glutamate ala UDP-N-acetyl-α-D-muramate ACP synthase α aspartate- EO217_RS12880 glucosamine-1- uxaC dehydrogenase: racemase: racE glutamate ala UDP-N-acetyl- -D-muramate II: fabF -tRNA sn-glycerol Inorganic Nutrient Metabolism phosphate N- D-tagaturonate EO217_RS12540 racemase: racE asp Man GlcNAc - Man GlcNAc - a double 1-oleoyl-sn a supercoiled an organic a (2E,5Z)- amino acid racemase: UDP-N-acetylmuramate- ligase: 3-phosphate a 3-oxoacyl-[acp] acetyltransferase F6P a (3Z)-docos- a cis,cis-delta15,27- a cis,cis-delta7,19- maltopentaose 7 2 8 2 O-succinyl-L- O-phospho- a [protein] Ser/Thr a 3-oxohexadecanoyl-[acp] tagaturonate a malonyl-[acp] a malonyl-[acp] a malonyl-[acp] [protein] (isomer [protein] (isomer methanethiol cys stranded DNA -glycerol 3- duplex DNA hydroperoxide tetradeca-2,5- EO217_RS04890 amino acid racemase: UDP-N-acetylmuramate- aspS 3-enoyl-[acp] C46:2-[acp] C38:2-[acp] homoserine L-homoserine -L-alanine ligase: an L-aspartyl- glycerol-3- urea cycle GlmU: glmU alpha-glucosidase: 7A B ) 8A B ) phosphate ATP-dependent alkyl dienoyl-[acp] EO217_RS04890 reductase: beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- 1,2,3 alpha-1,2-3 1,2,3 alpha-1,2-1,3 cystathionine cystathionine HPr kinase/ DNA/RNA 1-acyl-sn-glycerol- EO217_RS04545 -L-alanine ligase: [tRNA asp ] phosphate 1-O- 2-aminoethylphosphonate UDP-N-acetyl- EO217_RS03510 enoyl-ACP (R)-3- EO217_RS11590 ACP synthase ACP synthase ACP synthase mannosidase: mannosidase: gamma-synthase: gamma-synthase: phosphorylase: nuclease DNA helicase hydroperoxide D-glt EO217_RS04545 tRNA asp degradation I 3-phosphate hydroxypalmitoyl- acyltransferase α-D-glucosamine alpha-glucosidase: RecQ: reductase reductase UDP-N-acetyl-α-D-muramoyl-L-alanine D-glt 3-oxoacyl- II: fabF II: fabF II: fabF EO217_RS11525Man GlcNAc EO217_RS11525Man GlcNAc EO217_RS08110 EO217_RS08110 EO217_RS06245 SfsA: sfsA acyltransferase: arg β 6 2 β 5 2 FabI: fabI UDP-N-acetyl-α-D-muramoyl-L-alanine [acp] PlsY: plsY (2-aminoethyl) UDP-N-acetylglucosamine D-altronate a (5Z)-3-oxotetracos- a cis,cis-delta17,29- a cis,cis-delta9,21- EO217_RS08640 -D- -D- EO217_RS02000 subunit F: ahpF a 1-acyl-sn beta- [ACP] acyl-carrier protein acyl-carrier protein acyl-carrier protein -[protein] -[protein] succinate met L-cystathionine a [protein] (L-serine/L- EO217_RS11915 reductase: fabG phosphonate 1-carboxyvinyltransferase: 5-enoyl-[acp] 3-oxo-C48:2-[acp] 3-oxo-C40:2-[acp] mannopyranose mannopyranose a 5'-phosphooligonucleotide dioleoyl a single a (5Z)-tetradec- UDP-N-acetylmuramoyl- reductase: 2-aminoethylphosphonate- altronate D-glucopyranose maltotetraose (isomer 6A ) (isomer 5A ) threonine) phosphate an alcohol -glycerol 3- ketoacyl- 1,2,3 1,2 stranded DNA UDP-N-acetylmuramoyl- murA phosphatidate 5-enoyl-[acp] L-alanine--D-glutamate a (3R)-3- phosphate ACP fabG ammonium -pyruvate dehydratase: L-alanine--D-glutamate tyrosine-- UDP-N-acetylglucosamine ligase: EO217_RS14040 tyr hydroxyhexadecanoyl-[acp] 1-acyl-sn-glycerol- synthase transaminase: phnW EO217_RS11585 tRNA ligase: a (3R)-3- ligase: EO217_RS14040 a 2,3,4-saturated carbamoyl- phosphonoacetaldehyde 1-carboxyvinyltransferase: 3-hydroxyacyl- 3-phosphate II: fabF 2-dehydro-3- N-acetyl-D- Man GlcNAc - (2Z,4E)-2- 34 lys UDP-N-acetyl-α-D-muramoyl- EO217_RS08455 hydroxyacyl-[acyl- 6 2 a secondary a [protein]-L- an adenosine an L-tyrosyl- fatty acyl-[acp] 3-hydroxyacyl- phosphate EO217_RS13390 a 10- an L-methionyl- a cis,cis-delta9,21- a cis,cis-delta5,17- sucrose a DNA segment maltose α ACP dehydratase acyltransferase: deoxy-D-gluconate galactosamine [protein] (isomer hydroxyhexa- Arg2 L-alanyl-D-glutamate lys UDP-N-acetyl- -D-muramoyl- Tyr carrier protein] Met a malonyl-[acp] a malonyl-[acp] an oleoyl-[acp] alcohol proline (ω = 180) in [tRNA ] a butanoyl-[acp] [tRNA ] ACP L-arginino- synthase phosphonoacetaldehyde UDP-N-acetyl-α- formyltetrahydrofolate [initiator tRNA ] C40:2-[acp] C36:2-[acp] hypothetical alpha-glucosidase: L-alanyl-D-glutamate Tyr FabZ: fabZ EO217_RS11915 2-dehydro-3- 6-phosphate 6A B ) peptidylprolyl 2,4-dienedioate tRNA a tRNA L-ornithine methionyl-tRNA beta-ketoacyl- beta-ketoacyl- N-acetylglucosamine- 1,2 alpha-1,2-1 acyl-ACP recombinase RecT: zinc-binding alcohol a 1,2-diacyl- dehydratase succinate large hydrolase: EO217_RS05135 D-glucosamine- protein: EO217_RS03510 4-oxalocrotonate enoyl-ACP D-ala UDP-N-acetylmuramoyl- 3-hydroxyacyl- deoxygluconokinase: formyltransferase: mannosidase: isomerase: adenosine(34) sn-glycerol FabZ: fabZ subunit: carB enolpyruvate ACP synthase ACP synthase 6-phosphate thioesterase: EO217_RS04385 dehydrogenase: D-ala UDP-N-acetylmuramoyl- EO217_RS10555 alpha-glucosidase: EO217_RS02985 tautomerase: deaminase reductase L-alanyl-D-glutamate- ACP dehydratase acetaldehyde EO217_RS09160 an N-formyl- EO217_RS11035 II: fabF II: fabF α-D- deacetylase: nagA EO217_RS11525Man GlcNAc EO217_RS13225 [+ 2 isozymes] EO217_RS10575 3-phosphate 3-hydroxyacyl- UDP-N- β 5 2 EO217_RS14630 FabI: fabI -L- lysine ligase: L-alanyl-D-glutamate- FabZ: fabZ carbamoyl a cis,cis-delta11,23- a cis,cis-delta7,19- D-galactosamine -D- EO217_RS08640 [+ 4 isozymes] TadA: tadA D-alanine--D-alanine L-methionyl- a tetrahydrofolate acyl-carrier protein acyl-carrier protein glucopyranose β-D-fructofuranose acetate -[protein] oleate acyl-carrier protein a DNA segment in 34 phosphatidate ACP acetylmuramate KDGP 6-phosphate mannopyranose a ketone a [protein]-L- (3E)-2-oxohex- an inosine a (2E)-but- EO217_RS11460 D-alanine--D-alanine -L- lysine ligase: phosphate met 3-oxo-C42:2-[acp] 3-oxo-C38:2-[acp] D-glucopyranose ligase: EO217_RS09370 putrescine [initiator tRNA ] 1-phosphate (isomer 5A ) reverse orientation ω Arg2 tryptophan- cytidylyltransferase: dehydratase dehydrogenase: 1,2 proline ( = 0) 3-enedioate in [tRNA ] 2-enoyl-[acp] ligase: EO217_RS09370 EO217_RS11460 a tRNA Trp a (2E)-hexadec-2-enoyl-[acp] carbamoyltransferase: UDP-N-acetyl-α-D-muramoyl- -tRNA EO217_RS05095 FabZ: fabZ murB bifunctional D-alanyl-D-alanine EO217_RS13090 UDP-N-acetyl-α-D-muramoyl- a trans-2- L-alanyl-γ-D-glutamyl-L-lysine D-alanyl-D-alanine ligase: trpS an L-tryptophanyl- enoyl-ACP a CDP- a 2,3,4-saturated enoyl-ACP acetyl-CoA UDP-N-acetyl- 4-hydroxy-2- enoyl-[acyl- L-alanyl-γ-D-glutamyl-L-lysine Trp diacylglycerol L-citrulline α-D-muramate a 2,3,4-saturated Man GlcNAc - (25S)-3- [tRNA ] reductase fatty acyl-[acp] reductase oxoglutarate carbamoyl 9 2 (indol-3-yl) carrier protein] 16-hydroxypalmitate a cis,cis-delta3,15- a primary alcohol 2-hydroxyisobutyramide reduced riboflavin propanoate UDP-N-acetylmuramoyl- FabI: fabI FabI: fabI aldolase/2- an oleoyl-[acp] a malonyl-[acp] a malonyl-[acp] CTP 1,2-diacyl-sn- putrescine [protein] (isomer oxocholest- coenzyme A thr a myristoyl-[acp] trp CDP-diacylglycerol-- C34:2-[acp] phosphate acetamide tripeptide--D-alanyl- UDP-N-acetylmuramoyl- acyl-CoA synthetase: glycerol 3-phosphate 9A B ) 4-en-26-oate glycerol-3-phosphate 3- dehydro-3-deoxy- beta-ketoacyl- beta-ketoacyl- phosphatidate putrescine 1,2,3 1,2,3alpha-1,2- acyl-CoA zinc-binding alcohol tripeptide--D-alanyl- amidase: flavin reductase: amidase: L-threonine 3- acetate kinase: enoyl-ACP D- alanine ligase: vancomycin resistance I a palmitoyl-[acp] phosphatidyltransferase: phosphogluconate EO217_RS03490 ACP synthase ACP synthase cytidylyltransferase: carbamoyltransferase: mannosidase: synthetase: dehydrogenase: D- alanine ligase: enoyl-ACP UDP-N-acetyl- EO217_RS03620 EO217_RS12300 EO217_RS03620 dehydrogenase: EO217_RS11800 reductase EO217_RS09365 pgsA aldolase: II: fabF II: fabF EO217_RS05095 EO217_RS13090 EO217_RS11525Man GlcNAc (25S)-3- EO217_RS03490 EO217_RS10575 EO217_RS09365 reductase α-D-muramoyl- β-D- 5 2 EO217_RS03160 FabI: fabI acyl-ACP 1-(3-sn- EO217_RS09165 AMP diphosphate 16-hydroxypalmitoyl-CoA an (11Z)-3-oxo- a cis,cis-delta5,17- a CDP-2,3,4-saturated- N-carbamoylputrescine α D-alanyl-D-alanine threonine- FabI: fabI γ acyl-carrier protein acyl-carrier protein -[protein] oxocholest-4- 2-hydroxy-2- propanoyl UDP-N-acetyl- -D-muramoyl-L-alanyl- thr thioesterase: L-alanyl- -D- icos-11-enoyl-[acp] 3-oxo-C36:2-[acp] diacylglycerol mannopyranose an aldehyde riboflavin (indol-3-yl)acetate aminoacetone a (2E)-tetradec- pyruvate α phosphatidyl) D-glyceraldehyde (isomer 5A ) en-26-oyl-CoA methylpropanoate phosphate γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine UDP-N-acetyl- -D-muramoyl-L-alanyl- -tRNA glutamyl-meso-2,6- 1,2 EO217_RS13225 -sn-glycerol pyruvate Aldehyde Degradation 2-enoyl-[acp] γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine ligase: thrS an L-threonyl- diaminopimelate 3-phosphate 3-phosphate [tRNA Thr ] palmitate Thr phosphatidylglycerophosphatase methylglyoxal α a tRNA an apo-[LYS2 L- GlcMan GlcNAc γ a [protein]- an (2E,11Z) UDP-N-acetyl- -D-muramoyl-L- degradation I L-lactaldehyde a 2'-deoxyribonucleoside 9 2 lysine within -L-glutamyl-[(S an L-asparaginyl- D-ala acyl-CoA A: EO217_RS13025 18-hydroxystearate a cis,cis-delta7,25- a glutaryl-[acp] [DNA] (R)-lipoate oxaloacetate propan-1-ol butan-1-ol L-tyrosine γ (R)-lactate undecaprenyl-diphospho-N- degradation a malonyl-[acp] a malonyl-[acp] 2-aminoadipyl- coenzyme A -[protein] gcv protein H )-allyl]-L-cysteine Asn -icosa-2,11- alanyl- -D-glutamyl-L-lysyl-D-alanine synthetase: C44:2-[acp] methyl ester 5'-triphosphate [tRNA ] γ an L-1- acyl-CoA synthetase: carrier-protein] alpha-1,2- lipoate-- glutamyl phosphate dienoyl-[acp] acetylmuramoyl-L-alanyl- -D- methylglyoxal (anaerobic) beta-ketoacyl- beta-ketoacyl- DNA polymerase III holo-ACP synthase: phosphoenolpyruvate aminoacyl-tRNA zinc-binding alcohol zinc-binding alcohol EO217_RS03490 phosphatidyl- mannosidase: protein ligase: aminopeptidase: protein-tyrosine- enoyl-ACP glutamyl-L-lysyl- D-alanyl-D-alanine lactoylglutathione EO217_RS03490 ACP synthase ACP synthase subunit delta: holA carboxykinase (ATP) hydrolase: dehydrogenase: dehydrogenase: sn-glycerol (S)-lactaldehyde EO217_RS09355 EO217_RS11525 phosphatase: reductase undecaprenyldiphospho- serine- a holo-[LYS2 L- EO217_RS13585 pepA palmitoyl-CoA Carboxylate Degradation lyase: II: fabF II: fabF [+ 6 isozymes] D-glucosyl- Man GlcNAc - a [glycine-cleavage : EO217_RS07950 EO217_RS11110 EO217_RS10575 EO217_RS10575 undecaprenyl-diphospho-N L-ascorbate lactaldehyde 2-aminoadipyl- 3',5'-ADP 8 2 EO217_RS06025 FabI: fabI muramoylpentapeptide beta-N- -tRNA citrate degradation AMP diphosphate 18-hydroxystearoyl-CoA a cis,cis-delta9,27- a 3-oxopimeloyl- Asn -acetylmuramoyl-L-alanyl-γ- ser degradation I pyruvate decarboxylation to acetyl CoA EO217_RS04575 acyl-carrier protein acyl-carrier protein [DNA] α(1->3)- α- [protein] (isomer complex H protein] S-allyl-L-cysteine glu phosphoenol tRNA asn a [protein]- ligase: reductase: fucO 3-oxo-C46:2-[acp] [acp] methyl ester carrier-protein] 6 1-propanal butan-1-al D-alanyl-D-lactate acetylglucosaminyltransferase: (S)-propane- D-mannose 8A B ) N -lipoyl-L-lysine pyruvate a gondoyl-[acp] D-glutamyl-L-lysyl- D-alanine Carbohydrate Biosynthesis (bacterial, anaerobic) lactoylglutathione 1,2,3 1,2 L-tyrosine murG serS an L-seryl- undecaprenyldiphospho- L-ascorbate a [pyruvate dehydrogenase an acetyl-holo [citrate lyase: 1,2-diol ditrans,octacis-undecaprenyldiphospho- [tRNA ser ] 6 pyruvate citrate muramoylpentapeptide beta-N- 6-phosphate E2 protein] N -lipoyl-L-lysine lyase acyl-carrier protein] EO217_RS06615 N-acetyl-(N-acetyl-β-D-glucosaminyl) a tRNA ser UDP-N-acetyl-D- L-ascorbate dehydrogenase citrate lyase (R)-S- acetylglucosaminyltransferase: GDP-mannose biosynthesis UDP-α-D-glucose PRPP biosynthesis α muramoyl-L-alanyl-γ-D-glutamyl- glucosamine biosynthesis I 6-phosphate dihydrolipoamide (acetyl- subunit alpha: citF lactoylglutathione a ring-opened 7- p-nitrophenyl- -L- α-D-glucopyranose γ-L-glutamyl-(S)- (R)-10- a (2E,9Z)- murG biosynthesis I α-linolenate a malonyl-[acp] an apo [peptidyl- [EntB aryl- 4-guanidinobutyramide phytol DHAP L-lysyl-D-alanyl-D-alanine lactonase: dehydrogenase: transferring) pyruvate [+ 5 isozymes] methylguanine in DNA a malonyl-[acp] coenzyme A coenzyme A rhamnopyranoside a type IV prepilin 1-phosphate methyl-L-cysteine Hydroxystearate octadeca-2,9- ditrans,octacis-undecaprenyldiphospho- D-glucopyranose D-glucopyranose D-ribose 5- a citryl-holo [citrate methyl ester carrier protein] carrier protein] alpha-L- acyl-CoA synthetase: DNA- glutamyl dienoyl-[acp] D-glucopyranose ulaG EO217_RS07725 E1 component beta-ketoacyl- holo-ACP synthase: holo-ACP synthase: prepilin peptidase: zinc-binding alcohol N-acetyl-(N-acetylglucosaminyl)muramoyl- 6-phosphate 6-phosphate phosphate lyase acyl-carrier protein] formamidopyrimidine rhamnosidase: sugar-phosphatase: amidase: aminopeptidase: oleate hydratase: methylglyoxal enoyl-ACP glucose-6- glucose-6- 6-phosphate ribose-phosphate 3-keto-L-gulonate subunit EO217_RS03490 ACP synthase dehydrogenase: L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine proline-- phospho- dihydrolipoyl EO217_RS09355 EO217_RS09355 EO217_RS03395 EO217_RS10610 EO217_RS06605 reductase diphosphokinase: 6-phosphate glycosylase: mutM EO217_RS03620 pepA EO217_RS08835 synthase: mgsA pro phosphate phosphate dehydrogenase: alpha: pdhA citrate lyase (R)-lactate 2,6-diamino-4- II: fabF a holo [peptidyl- a holo-[EntB aryl- β a cleaved type EO217_RS10575 ditrans,octacis-undecaprenyldiphospho- tRNA ligase: sugar mutase: α an apurinic site 3',5'-ADP 3',5'-ADP -L- a peptide S-methyl- FabI: fabI isomerase: isomerase: EO217_RS07720 subunit alpha: citF AMP diphosphate -linolenoyl-CoA hydroxy-5-(N-methyl) a 3-oxoglutaryl- 4-nitrophenol glu N-acetyl-(N-acetylglucosaminyl) EO217_RS05085 EO217_RS06125 3-dehydro-L- lpdA acyl-carrier protein carrier protein] carrier protein] rhamnopyranose IV prepilin D-glucopyranose an L-prolyl- pyruvate fermentation to acetate IV within DNA [acp] methyl ester 4-guanidinobutanoate L-cysteine oleate phytenal methylglyoxal γ EO217_RS05355 EO217_RS05355 ribose-phosphate gulonate-6- [+ 5 isozymes] formamidopyrimidine an oleoyl-[acp] muramoyl-L-alanyl- -D-isoglutaminyl- [tRNA Pro ] phosphomannomutase/ a [pyruvate dehydrogenase ditrans,octacis-undecaprenyldiphospho- F6P F6P diphosphokinase: a [pyruvate dehydrogenase L-lysyl-D-alanyl-D-alanine Pro phosphate 6 N-acetyl-(N-acetylglucosaminyl) a tRNA phosphoglucomutase: E2 protein] N - E2 protein] N 6 -S- oxaloacetate EO217_RS10975 decarboxylase: pyruvate muramoyl-L-alanyl-γ-D- D-aspartate ligase: glutamine-- mannose-6- EO217_RS07925 dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine α-D-glucopyranose PRPP EO217_RS01570 pyruvate isoglutaminyl-L-lysyl-D-alanine EO217_RS04895 fructose-6- phosphate a single phosphoenol an [HPr]- a 7,8-dihydro-8- a 6-phospho- (R)-propane- 1-phosphate L-xylulose an apo-[aryl- 2-oxoglutarate β a sugar phosphate N-formyl- β-aspartyl dipeptide butan-1-ol acrylamide arsenate ditrans,octacis-undecaprenyldiphospho- phosphate isomerase, formate C- stranded DNA pyruvate L-histidine DL-allothreonine oxoguanine in DNA coenzyme A -D-galactoside 1,2-diol D-aspartate ligase: 5-phosphate exodeoxyribonuclease phosphoenolpyruvate- carrier protein] 6-phospho-beta- L-glutamate beta-aspartyl- N-acetyl-(N-acetylglucosaminyl)muramoyl- phenylalanine-- transaminase class I: manA UTP--glucose- acetyltransferase: serine DNA- dihydrolipoamide N-formylglutamate zinc-binding alcohol arsenate EO217_RS04895 holo-ACP synthase: galactosidase: sugar-phosphatase: lactaldehyde amidase: γ β tRNA ligase: pheS (isomerizing) D-mannopyranose 1-phosphate dTDP-L-rhamnose L-ribulose-5- dihydrolipoyllysine- VII: EO217_RS13970 -protein formamidopyrimidine dehydrogenase: peptidase: reductase L-alanyl- -D-isoglutaminyl-N-( -D- pflB hydroxymethyltransferase: EO217_RS09355 amidohydrolase: dehydrogenase: ditrans,octacis-undecaprenyldiphospho- phe uridylyltransferase biosynthesis EO217_RS13975 phosphotransferase: ptsP glycosylase: mutM EO217_RS07725 lacG EO217_RS06605 iadA reductase: fucO EO217_RS03620 (thioredoxin) asparatyl)-L-lysyl-D-alanyl-D-alanine EO217_RS02915 : glmS 6-phosphate phosphate 3- acetyl-CoA residue an [HPr protein]- EO217_RS12615 EO217_RS01055 EO217_RS10575 N-acetyl-(N-acetylglucosaminyl) a single-stranded a ribonucleoside an apurinic site 7,8-dihydro- a holo-[aryl- D-galactopyranose GalU: galU α epimerase: acetyltransferase: π 3',5'-ADP NADH CO succinyl-CoA an alcohol a proteinogenic : arsC [+ 2 isozymes] an L-phenylalanyl- D-glucosamine phosphomannomutase/ -D-glucopyranose N -phospho- pyruvate gly acetaldehyde carrier protein] 2 formate glu asp muramoyl-L-alanyl-γ-D-isoglutaminyl- acetyl-CoA formate oligodeoxyribonucleotide 5'-monophosphate within DNA 8-oxoguanine 6-phosphate a sugar amino acid butan-1-al (R)-lactaldehyde acrylate Phe UTP--glucose- EO217_RS01575 EO217_RS02610 arsenite N-(β-D-asparatyl)-L-lysyl-D-alanine [tRNA ] 6-phosphate phosphoglucomutase: 1-phosphate L-histidine Phe 1-phosphate glucose-1-phosphate L-ribulose 5- ditrans,octacis-undecaprenyldiphospho- a tRNA phosphoglucosamine EO217_RS07925 phosphate uridylyltransferase thymidylyltransferase phosphate N-acetyl-(N-acetylglucosaminyl)muramoyl- mutase: α-D-mannose acetyltransferase: pta RfbA: rfbA D-gluconate γ β EO217_RS04835 1-phosphate GalU: galU L-ribulose-5- β-L-galactose D-ribose 5- L-alanyl- -D-isoglutaminyl-N-( -D- dTDP-α-D-glucose pristanate an acyl-[acyl- nicotinate PRPP [EntF L-seryl- rutin quercitrin ethanol formate CTP formate UTP propionamide acetamide ditrans,octacis-undecaprenyldiphospho- degradation a malonyl-[acp] coenzyme A 1-phosphate phosphate asparaginyl)-L-lysyl-D-alanyl-D-alanine α-D-glucosamine α phosphate 4- acetyl phosphate ammonium hydrogencarbonate ATP carrier protein] carrier protein] N-acetyl-(N-acetylglucosaminyl) UDP- -D-glucose dTDP-glucose 4,6- nicotinate alpha-L- alpha-L- ribose-5- 1-phosphate epimerase: acyl-CoA synthetase: beta-ketoacyl- zinc-binding alcohol anaerobic anaerobic muramoyl-L-alanyl-γ-D-isoglutaminyl- methionine- D-gluconate holo-ACP synthase: sugar-phosphatase: amidase: amidase: met dehydratase: rfbB EO217_RS01580 carbamate kinase: arcC EO217_RS03490 ACP synthase phosphoribosyltransferase: rhamnosidase: rhamnosidase: dehydrogenase: ribonucleoside- ribonucleoside- phosphate β -tRNA bifunctional UDP-N- GDP-α-D- gluconokinase: acetate kinase: EO217_RS09355 EO217_RS06605 EO217_RS03620 EO217_RS03620 N-( -D-asparaginyl)-L-lysyl-D-alanine dTDP-4-dehydro-6- carbamate kinase: arcC EO217_RS12350 a holo-[EntF EO217_RS03395 EO217_RS03395 isomerase ligase: metG an L-methionyl- L-ribulose-5- II: fabF β-L- β-L- EO217_RS10575 triphosphate triphosphate acetylglucosamine mannose α EO217_RS10615 EO217_RS11800 AMP diphosphate pristanoyl-CoA 3',5'-ADP L-seryl-carrier quercetin- RpiA: rpiA a peptidoglycan dimer (E. faeciums) [elongator deoxy- -D-glucopyranose D-gluconate carbamoyl phosphate NaMN quercetin reductase: nrdD reductase: nrdD diphosphorylase/ phosphate 4- acyl-carrier protein a 3-oxoacyl-[acp] rhamnopyranose 3-glucoside rhamnopyranose L-galactopyranose acetaldehyde propanoate acetate D-ribulose elongator tRNA Met ] dTDP-4- protein] dCTP dUTP glucosamine-1- epimerase: 6-phosphate acetate 5-phosphate a peptidoglycan dimer tRNA Met dehydrorhamnose phosphate N- EO217_RS12415 (E. faecium, tetrapeptide) 3,5-epimerase: rfbC acetyltransferase D-xylulose a peptidoglycan tetramer with a D,D UDP-α-D- dTDP-4-dehydro- 5-amino-4- a 2-O-acetylated a [lipoyl-carrier D-gluconate D-mannitol phosphoenol GlmU: glmU 5-phosphate PRPP phytenate [DNA] hesperidin (R)-lipoate L-arabinitol D-glucopyranose methylglyoxal (R)-mevalonate cross-link (Enterococcus faecium) galactose β-L-rhamnose imidazolecarboxyamide rhamnogalacturonan I VibB coenzyme A protein]-L-lysine 6-phosphate 1-phosphate pyruvate N-acetyl-α-D- lysine- adenine acyl-CoA synthetase: rhamnogalacturonan exodeoxyribonuclease alpha-L- lipoate-- zinc-binding alcohol glucose 1- a tRNA Lys biosynthesis dTDP-4- decarboxylating 6- glyoxalase: a peptidoglycan tetramer with an L,D -tRNA glucosamine acetylesterase: holo-ACP synthase: rhamnosidase: sugar-phosphatase: mevalonate pyruvate dehydrorhamnose phosphoribosyltransferase: EO217_RS03490 III: xth protein ligase: dehydrogenase: phosphogluconate dehydrogenase: EO217_RS02145 cross-link (Enterococcus faecium) 1-phosphate UDP-α-D-glucose a 2'- EO217_RS09355 ligase: lysS an L-lysyl- L-serine Amino Acid Degradation EO217_RS03035 EO217_RS11575 EO217_RS03395 EO217_RS13585 EO217_RS10575 EO217_RS06605 EO217_RS05025 kinase: mvk kinase: pyk a peptidoglycan with (L- UDP-glucose reductase: rfbD L-citrulline degradation deoxyribonucleoside [DNA] a holo-[VibB aryl- β-L- hesperitin-7-O- dehydrogenase: gnd [+ 2 isozymes] Lys bifunctional UDP-N- degradation glycine cleavage a rhamnogalacturonan a [lipoyl-carrier protein]- [tRNA ] L-aspartate AICAR diphosphate AMP phytenoyl-CoA acetate 3',5'-ADP D-ribulose D-glucono- alanyl-γ-D-glutamyl-L-lysyl-D- 4-epimerase dTDP-β-L-rhamnose type I 5'-monophosphate carrier protein] rhamnopyranose β-D-glucoside N 6 -lipoyl-L-lysine L-arabinopyranose D-mannitol (R)-5- lys acetylglucosamine degradation I (R)-lactate pyruvate alanyl-D-alanine) pentapeptide GalE: galE a [glycine- 5-phosphate 1,5-lactone phosphomevalonate a peptidoglycan with (L- diphosphorylase/ UDP-α-D-galactose ser L-citrulline cleavage complex alanyl-γ-D-glutamyl-L-lysyl-D- glucosamine-1- L-serine putrescine H protein] N 6 - asp alanyl-D-alanine) pentapeptide phosphate N- glycine cleavage L-threonine 3-[(3aS,4S,7aS)-7a-methyl- a 3-O-acetylated an α(1,5)- ammonia- carbamoyltransferase: D-glucopyranose D-sorbitol + lipoyl-L-lysine system protein H: degradation II bifunctional decanoate AsbD acyl- a ribonucleic acid naringin a tripeptide D-glucopyranose pyrazinamide NAD β-D-allopyranose a peptidoglycan with (L- acetyltransferase 1,5-dioxo-octahydro-1H coenzyme A rhamnogalacturonan I L-arabinan coenzyme A 6-phosphate 6-phosphate histidine-- lyase, EO217_RS13090 carrier protein alanyl-γ-D-glutamyl-L-lysyl-D- his GlmU: glmU carbamoyl glycine cleavage EO217_RS07615 aspartate -inden-4-yl]propanoate acyl-CoA synthetase: rhamnogalacturonan alpha-L- ribonuclease PH: alpha-L- peptidase glucose 1- D-ribose tRNA ligase: iron-sulfur- acyl-CoA synthetase: holo-ACP synthase: alanyl-D-alanine) pentapeptide phosphate system protein H: thr transaminase/ EO217_RS03490 acetylesterase: arabinofuranosidase: EO217_RS02950 rhamnosidase: T: pepT sugar-phosphatase: sugar-phosphatase: dehydrogenase: amidase: NAD kinase: pyranase: a peptidoglycan with (L- UDP-N-acetyl- dependent, EO217_RS03490 EO217_RS11885 an L-histidyl- EO217_RS07615 aspartate 4- 3-[(3aS,4S,7aS)-7a-methyl- EO217_RS11575 EO217_RS12390 EO217_RS09355 EO217_RS03395 EO217_RS06605 EO217_RS06605 EO217_RS03620 EO217_RS11975 γ α-D-glucosamine carbamoyl- L-threonine 3- a nucleoside a proteinogenic EO217_RS05025 rbsD alanyl- -D-glutamyl-L-lysyl-D- His subunit a rhamnogalacturonan an α(1,5)- α-L- a holo-[AsbD acyl- a ribonucleic acid β-L- a dipeptide [tRNA ] [+ 2 isozymes] dehydrogenase: decarboxylase: 1,5-dioxo-octahydro-1H- diphosphate AMP decanoyl-CoA 3',5'-ADP diphosphate prunin amino acid His phosphate a [glycine- acetate D-glucono- β alanyl-D-alanine) pentapeptide beta: sdaAB L-arabinan arabinofuranose carrier protein] rhamnopyranose pyrazine-2- + -D-allofuranose a tRNA 2-aminoprop- a [glycine-cleavage EO217_RS01115 inden-4-yl]propanoyl-CoA type I D-glucopyranose D-sorbitol NADP synthase cleavage complex EO217_RS03160 1,5-lactone carboxylate 6 L-2-amino-3- oxaloacetate 2-enoate 6 complex H protein] N - large H protein] N - oxobutanoate aminomethyldihydrolipoyl- subunit: carB dihydrolipoyl- L-lysine glycine C- a DNA containing L-lysine a single- RNase R degradation (5Z,8Z,11Z,14Z,17Z) + + 2'-deoxycytidine an organic [+ 2 isozymes] dioscin coenzyme A FMN NAD(P)H H FMNH NADP glycerol pyruvate 2-oxobutanoate sec glycine-- acetyltransferase: L-glutamine an acetyl-[acp] a malonyl-[acp] an apurinic/ 2 a tRNA ser stranded RNA substrate RNA -icosapentaenoate deoxynucleoside molecule tRNA ligase: EO217_RS03155 degradation I polyribonucleotide alpha-L- ribonuclease acyl-CoA apyrimidinic site flavin reductase: flavin reductase: zinc-binding alcohol acetolactate gly 2-iminopropanoate carbamate beta-ketoacyl-ACP endonuclease kinase: serine--tRNA EO217_RS06050 nucleotidyltransferase: pnp rhamnosidase: R: rnr synthetase: EO217_RS12300 EO217_RS12300 dehydrogenase: synthase cytochrome P450: glycine cleavage synthase II: fabF III: nth EO217_RS09125 ligase: serS glyQ gly a nucleoside a single- EO217_RS03395 a nucleoside 5'- EO217_RS03490 + + EO217_RS10575 AlsS: alsS EO217_RS11870 Gly gln a 5'-phospho- a 3'-terminal NAD(P) FMNH H NADPH FMN a glycyl-[tRNA ] L-asparagine system protein H: 3-O-β-D-glucosyl- a diribonucleotide (5Z,8Z,11Z,14Z,17Z) 2 (S)-2-aceto-2- [+ 2 isozymes] sec diphosphate stranded RNA an acetoacetyl-[acp] acyl-carrier protein L-rhamnopyranose monophosphate [DNA] unsaturated sugar an L-seryl-[tRNA ] degradation I EO217_RS07615 carbamoyl- L-glyceraldehyde Gly diosgenin -icosapentaenoyl-CoA hydroxybutanoate dCMP an alcohol a tRNA phosphate pyruvate CO synthase large 2 asn subunit: carB asparaginase: a 5S rRNA D-sedoheptulose D-glyceraldehyde 7,8- D-erythrose D-xylulose a dipetide with an N- uridine [+ 5 isozymes] acetoacetyl-CoA H O acetyl-CoA a single a ribonucleoside FMN NADH H + xylitol a pectin pyruvate 2 precursor 7-phosphate 3-phosphate dihydromonapterin 4-phosphate 5-phosphate terminal L-aspartate methionine- EO217_RS13230 glu 4'-phosphopantetheine ATP stranded DNA triphosphate met hydroxymethylglutaryl-CoA ribonuclease dihydroneopterin flavin reductase: zinc-binding alcohol pectin esterase: dipeptidase uridine kinase: transketolase: tkt DNA primase: transketolase: tkt pyruvate -tRNA asp EO217_RS11645 synthase: EO217_RS01855 pantetheine-phosphate M5: rnmV aldolase: folB EO217_RS01920 EO217_RS12300 dehydrogenase: PepV: pepV carboxylase: EO217_RS09405 ligase: metG an L-methionyl- a double-stranded D-xylulose D-ribose 5- 6-(hydroxymethyl) D-glyceraldehyde adenylyltransferase: coaD ssDNA/pppN(pN) F6P + EO217_RS10575 MeOH a pectate a proteinogenic EO217_RS02650 Met HMG-CoA a mature 5S-rRNA glycolaldehyde NAD FMNH asp [initiator tRNA ] 3'-dephospho-CoA oligonucleotide 5-phosphate phosphate -7,8-dihydropterin hybrid 3-phosphate 2 amino acid UMP Met n -1 D-xylopyranose initiator tRNA oxaloacetate an L-sorbose 1-phosphate D-fructose 1-phosphate an amino an amino D-mannose 6-phosphate a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- D-glucose 6- D-glucose 6- acid acid D-mannitol D-mannose phosphate D-sorbitol a sugar 6- a sugar 6- choline a β- a β- a β- a β- a β- a β- a β- a β- a branched- a branched- a branched- an L-sorbose 1-phosphate an L-sorbose 1-phosphate phosphate phosphate phosphate phosphate phosphate phosphonate phosphate phosphate phosphate 1-phosphate a carbohydrate 6-phosphate 6-phosphate phosphate phosphate a sugar 6- glycine betaine a sugar 6- D-fructose D-fructose D-fructose D-fructose D-fructose D-glucose 6- an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino a 2-hydroxy a 2-hydroxy a 2-hydroxy L-ascorbate L-ascorbate a sugar 6- D-mannitol D-mannose D-mannose a sugar 6- a sugar 6- D-sorbitol a sugar 6- a sugar 6- a sugar 6- glycine betaine phosphonate glucoside 6- glucoside 6- glucoside 6- glucoside 6- glucoside 6- glucoside 6- glucoside 6- glucoside 6- chain chain chain D-fructose 1-phosphate D-fructose 1-phosphate phosphate phosphate phosphate pro phosphate 1-phosphate 1-phosphate 1-phosphate 1-phosphate 1-phosphate phosphate acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid carboxylate carboxylate carboxylate 6-phosphate 6-phosphate phosphate 1-phosphate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate 6-phosphate 6-phosphate phosphate phosphate 6-phosphate phosphate phosphate phosphate pro phosphate phosphate phosphate phosphate phosphate phosphate phosphate phosphate amino acid amino acid amino acid D-mannose 6-phosphate predicted D-mannose 6-phosphate predicted predicted PEP-driven predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC ABC predicted ABC transporter PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven PEP-driven ABC PEP-driven PEP-driven PEP-driven RS13410 RS09270 RS12185 RS12305 RS00055 transporter of RS03945 RS04770 RS05955 RS13920 RS13415 RS08415 RS03790 RS07215 RS07265 RS07775 RS07985 RS08445 RS04915 RS08795 RS08800 RS09505 RS09510 transporter transporter RS05825 RS12790 RS03165 RS03610 RS06815 RS00380 RS01195 RS01560 RS03400 RS05610 RS07420 RS01340 RS08625 RS00280 RS07225 RS13175 RS06155 RS01635 RS01640 RS09520 RS06090 RS03545 RS07825 RS04640 RS05475 transporter of RS10570 RS11490 RS11610 RS12380 RS03960 of D- RS12850 RS12865 RS13925 RS12505 RS05715 RS00050 RS01755 RS12450 RS08995 RS00230 RS06345 transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter transporter phosphonate of an of an a carbohydrate mannose/ of a sugar of a sugar of a sugar of a sugar of a sugar of a sugar of D-glucose of D-glucose of D-mannitol of D-mannose of phosphate of D-sorbitol of a sugar of a sugar amino acid amino acid D-fructose/ L-sorbose

choline glycine betaine a 2-hydroxy a 2-hydroxy a 2-hydroxy a branched- a branched- a branched- L-sorbose L-sorbose L-sorbose a sugar a sugar a sugar a sugar a sugar a sugar a sugar phosphonate phosphonate a sugar D-fructose D-fructose D-fructose D-fructose D-fructose D-glucose D-glucose D-glucose an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino L-ascorbate L-ascorbate a β-glucoside a β-glucoside a β-glucoside a β-glucoside a β-glucoside a β-glucoside a β-glucoside a β-glucoside a sugar D-mannitol D-mannitol a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate D-mannose D-mannose D-mannose a sugar a sugar D-sorbitol D-sorbitol a sugar a sugar a sugar a sugar a sugar glycine betaine chain chain chain D-fructose D-fructose D-fructose phosphate phosphate phosphate pro acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid carboxylate carboxylate carboxylate pro amino acid amino acid amino acid D-mannose D-mannose D-mannose This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.