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Transmission and Evolution of Tick-Borne Viruses
Available online at www.sciencedirect.com ScienceDirect Transmission and evolution of tick-borne viruses Doug E Brackney and Philip M Armstrong Ticks transmit a diverse array of viruses such as tick-borne Bourbon viruses in the U.S. [6,7]. These trends are driven encephalitis virus, Powassan virus, and Crimean-Congo by the proliferation of ticks in many regions of the world hemorrhagic fever virus that are reemerging in many parts of and by human encroachment into tick-infested habitats. the world. Most tick-borne viruses (TBVs) are RNA viruses that In addition, most TBVs are RNA viruses that mutate replicate using error-prone polymerases and produce faster than DNA-based organisms and replicate to high genetically diverse viral populations that facilitate their rapid population sizes within individual hosts to form a hetero- evolution and adaptation to novel environments. This article geneous population of closely related viral variants reviews the mechanisms of virus transmission by tick vectors, termed a mutant swarm or quasispecies [8]. This popula- the molecular evolution of TBVs circulating in nature, and the tion structure allows RNA viruses to rapidly evolve and processes shaping viral diversity within hosts to better adapt into new ecological niches, and to develop new understand how these viruses may become public health biological properties that can lead to changes in disease threats. In addition, remaining questions and future directions patterns and virulence [9]. The purpose of this paper is to for research are discussed. review the mechanisms of virus transmission among Address vector ticks and vertebrate hosts and to examine the Department of Environmental Sciences, Center for Vector Biology & diversity and molecular evolution of TBVs circulating Zoonotic Diseases, The Connecticut Agricultural Experiment Station, in nature. -
Wnv-Case-Definition.Pdf
Draft Case Definition for West Nile Fever Animal and Plant Health Inspection Service West Nile Fever Veterinary Services October 2018 Case Definition (Notifiable) 1. Clinical Signs 1.1 Clinical Signs: West Nile Fever (WNF) is a zoonotic mosquito-borne viral disease caused by the West Nile virus (WNV), a Flavivirus of the family Flaviviridae. Many vertebrate species are susceptible to natural WNV infection; however, fatal neurological outbreaks have only been documented in equids, humans, geese, wild birds (particularly corvids), squirrels, farmed alligators, and dogs. Birds serve as the natural host reservoir of WNV. The incubation period is estimated to be three to 15 days in horses Ten to 39 percent of unvaccinated horses infected with WNV will develop clinical signs. Most clinically affected horses exhibit neurological signs such as ataxia (including stumbling, staggering, wobbly gait, or incoordination) or at least two of the following: circling, hind limb weakness, recumbency or inability to stand (or both), multiple limb paralysis, muscle fasciculation, proprioceptive deficits, altered mental status, blindness, lip droop/paralysis, teeth grinding. Behavioral changes including somnolence, listlessness, apprehension, or periods of hyperexcitability may occur. Other common clinical signs include colic, lameness, anorexia, and fever. 2. Laboratory criteria: 2.1 Agent isolation and identification: The virus can be identified by polymerase chain reaction (PCR) and virus isolation (VI). Preferred tissues from equids are brain or spinal cord. 2.2 Serology: Antibody titers can be identified in paired serum samples by IgM and IgG capture enzyme linked immunosorbent assay (ELISA), plaque reduction neutralization test (PRNT), and virus neutralization (VN). Only a single serum sample is required for IgM capture ELISA, and this is the preferred serologic test in live animals. -
Rift Valley Fever for Host Innate Immunity in Resistance to a New
A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever This information is current as Tânia Zaverucha do Valle, Agnès Billecocq, Laurent of September 25, 2021. Guillemot, Rudi Alberts, Céline Gommet, Robert Geffers, Kátia Calabrese, Klaus Schughart, Michèle Bouloy, Xavier Montagutelli and Jean-Jacques Panthier J Immunol 2010; 185:6146-6156; Prepublished online 11 October 2010; Downloaded from doi: 10.4049/jimmunol.1000949 http://www.jimmunol.org/content/185/10/6146 Supplementary http://www.jimmunol.org/content/suppl/2010/10/12/jimmunol.100094 http://www.jimmunol.org/ Material 9.DC1 References This article cites 46 articles, 17 of which you can access for free at: http://www.jimmunol.org/content/185/10/6146.full#ref-list-1 Why The JI? Submit online. by guest on September 25, 2021 • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2010 by The American -
Clinically Important Vector-Borne Diseases of Europe
Natalie Cleton, DVM Erasmus MC, Rotterdam Department of Viroscience [email protected] No potential conflicts of interest to disclose © by author ESCMID Online Lecture Library Erasmus Medical Centre Department of Viroscience Laboratory Diagnosis of Arboviruses © by author Natalie Cleton ESCMID Online LectureMarion Library Koopmans Chantal Reusken [email protected] Distribution Arboviruses with public health impact have a global and ever changing distribution © by author ESCMID Online Lecture Library Notifications of vector-borne diseases in the last 6 months on Healthmap.org Syndromes of arboviral diseases 1) Febrile syndrome: – Fever & Malaise – Headache & retro-orbital pain – Myalgia 2) Neurological syndrome: – Meningitis, encephalitis & myelitis – Convulsions & coma – Paralysis 3) Hemorrhagic syndrome: – Low platelet count, liver enlargement – Petechiae © by author – Spontaneous or persistent bleeding – Shock 4) Arthralgia,ESCMID Arthritis and Online Rash: Lecture Library – Exanthema or maculopapular rash – Polyarthralgia & polyarthritis Human arboviruses: 4 main virus families Family Genus Species examples Flaviviridae flavivirus Dengue 1-5 (DENV) West Nile virus (WNV) Yellow fever virus (YFV) Zika virus (ZIKV) Tick-borne encephalitis virus (TBEV) Togaviridae alphavirus Chikungunya virus (CHIKV) O’Nyong Nyong virus (ONNV) Mayaro virus (MAYV) Sindbis virus (SINV) Ross River virus (RRV) Barmah forest virus (BFV) Bunyaviridae nairo-, phlebo-©, orthobunyavirus by authorCrimean -Congo heamoragic fever (CCHFV) Sandfly fever virus -
West Nile Virus Questions and Answers
West Nile Virus Questions and Answers Q: How do people get infected with West Nile Virus (WNV)? A: The most likely way a human would become infected with WNV is through the bite of an infected mosquito. Some people have also become infected with WNV following receipt of contaminated blood or blood products, or transplanted organs from an infected donor. Mothers who are recently infected with WNV may also transmit the virus to their unborn child, or to their baby while breastfeeding. Q: Who is at risk for getting West Nile encephalitis? A: All residents of areas where WNV activity has been identified are at risk of getting West Nile encephalitis. Q: What is the time from exposure to onset of disease symptoms for West Nile encephalitis in humans? A: Usually 3 to 15 days. Q: What are the symptoms of West Nile virus infection? A: Most people who are infected with WNV will not have any noticeable illness, or have a mild form of illness called West Nile Fever. Persons with West Nile Fever typically experience symptoms of fever, headache, nausea, muscle weakness, and body aches lasting 2 to 6 days or longer. Sensitivity when looking at light and a skin rash appearing on the trunk of the body may also be present. Approximately 20% of persons infected with WNV will develop more severe neurologic disease that may be life-threatening. Adults over the age of 50 years are at greater risk of having serious disease. Potential symptoms of severe infection (West Nile encephalitis or meningitis) include intense headache, dizziness, severe muscle weakness, neck stiffness, vomiting, disorientation, mental confusion, tremors, muscle paralysis, or convulsions and coma. -
West Nile Virus
Oklahoma State Department of Health Acute Disease Service Public Health Fact Sheet West Nile Virus What is West Nile virus? West Nile virus is one of a group of viruses called arboviruses that are spread by mosquitoes and may cause illness in birds, animals, and humans. West Nile virus was not known to be present in the United States until the summer of 1999. Previously, West Nile virus was only found in Africa, western Asia, the Middle East, and Eastern Europe. Where is West Nile virus in the United States? West Nile virus was first identified as a disease threat in the United States during the summer of 1999 and was limited to the northeastern states through 2000. However, the virus rapidly expanded its geographic range. By the end of 2004, West Nile virus had spread from the Atlantic to the Pacific coast with viral activity confirmed in all 48 contiguous states. How is it spread? West Nile virus is primarily spread through the bite of an infected mosquito. Mosquitoes pick up the virus when they feed on infected birds. The virus must then circulate in the mosquito for a few days before they are capable of passing the infection to animals or humans while biting. West Nile virus is not spread person to person through casual contact such as touching or kissing. Rarely, West Nile virus has also been spread through blood transfusions, although blood banks do screen blood supply for the infection. How long does it take to get sick after a bite from an infected mosquito? It takes about three to 15 days for both human and equine (horse, mule, or donkey) illness to occur after a bite from infected mosquito. -
When Neglected Tropical Diseases Knock on California's Door
When Neglected Tropical Diseases Knock on California’s Door Anne Kjemtrup, DVM, MPVM, PhD California Department of Public Health Vector-Borne Disease Section Overview of Today’s Topics • Neglected tropical diseases: setting the stage for impact on California • California Public Health Overview – Surveillance/response structure – Vector-Borne Disease program areas THE MONSTER RETURNS • Two examples: Peter McCarty – Arbovirus introduction (dengue, chikungunya, zika) – Re-emergence of Rocky Mountain spotted fever (not really NTD but similar principals) Neglected Tropical Diseases* • Buruli Ulcer • Leishmaniasis • Chagas disease • Leprosy (Hansen disease) • Dengue and Chikungunya • Lymphatic filariasis • Dracunculiasis (guinea • Onchocerciasis (river worm disease) blindness) • Echinococcosis • Mycetoma • Endemic treponematoses • Rabies (Yaws) • Schistosomiasis • Foodborne trematodiases • Soil-transmitted • Human African helminthiases trypanosomiasis (sleeping • Taeniasis/Cysticercosis sickness) • Trachoma * from: http://www.who.int/neglected_diseases/diseases/en/ Neglected Tropical Diseases • Buruli Ulcer • Leishmaniasis • Chagas disease • Leprosy (Hansen disease) • Dengue and Chikungunya • Lymphatic filariasis • Dracunculiasis (guinea • Mycetoma worm disease) • Onchocerciasis (river • Echinococcosis blindness) • Endemic treponematoses • Rabies (Yaws) • Schistosomiasis • Foodborne trematodiases • Soil-transmitted • Human African helminthiases trypanosomiasis (sleeping • Taeniasis/Cysticercosis sickness) • Trachoma California has vector and/or -
The Ecology of New Constituents of the Tick Virome and Their Relevance to Public Health
viruses Review The Ecology of New Constituents of the Tick Virome and Their Relevance to Public Health Kurt J. Vandegrift 1 and Amit Kapoor 2,3,* 1 The Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; [email protected] 2 Center for Vaccines and Immunity, Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA 3 Department of Pediatrics, Ohio State University, Columbus, OH 43205, USA * Correspondence: [email protected] Received: 21 March 2019; Accepted: 29 May 2019; Published: 7 June 2019 Abstract: Ticks are vectors of several pathogens that can be transmitted to humans and their geographic ranges are expanding. The exposure of ticks to new hosts in a rapidly changing environment is likely to further increase the prevalence and diversity of tick-borne diseases. Although ticks are known to transmit bacteria and viruses, most studies of tick-borne disease have focused upon Lyme disease, which is caused by infection with Borrelia burgdorferi. Until recently, ticks were considered as the vectors of a few viruses that can infect humans and animals, such as Powassan, Tick-Borne Encephalitis and Crimean–Congo hemorrhagic fever viruses. Interestingly, however, several new studies undertaken to reveal the etiology of unknown human febrile illnesses, or to describe the virome of ticks collected in different countries, have uncovered a plethora of novel viruses in ticks. Here, we compared the virome compositions of ticks from different countries and our analysis indicates that the global tick virome is dominated by RNA viruses. Comparative phylogenetic analyses of tick viruses from these different countries reveals distinct geographical clustering of the new tick viruses. -
Tick Talk: Advancing the Understanding and Prevention of Tick-Borne Diseases
Tick Talk: Advancing the Understanding and Prevention of Tick-borne Diseases Seemay Chou UCSF Dept of Biochemistry & Biophysics Osher Mini Med School, 11/14/19 Malaria Sleeping sickness Lyme disease Topics: 1. Ticks and their vector capacity 2. Challenges associated with diagnosing Lyme 3. Strategies for blocking tick-borne diseases 4. What else can we learn from ticks? Ticks are vectors for human diseases Lyme Disease Ixodes scapularis Anaplasmosis Ixodes pacificus Babesiosis Powassan Disease Dermacentor andersoni Rocky Mountain Spotted Fever Dermacentor variablis Colorado Tick Fever Ehrlichiosis Amblyomma maculatum Rickettsiosis Amblyomma americanum Mammalian Meat Allergy Different ticks have different lifestyles Hard scutum Soft capitulum Ixodes scapularis Ornithodoros savignyi Different ticks have different lifestyles Hard • 3 stages: larvae, nymphs, adults • Single bloodmeal between each • Bloodmeal: days to over a week Ixodes scapularis Lyme disease cases in the U.S. are on the rise Ixodes scapularis Borrelia burgdorferi Lyme disease Cases have tripled in past decade Most commonly reported vector-borne disease in U.S. Centers for Disease Control Tick–pathogen relationships are remarkably specific Source: CDC.gov Lyme disease is restricted to where tick vectors are Source: CDC.gov West coast vector: Ixodes pacificus Western blacklegged tick West coast vector: Ixodes pacificus Sceloporus occidentalis Western fence lizard County level distribution of submitted Ixodes Nieto et al, 2018 Distribution of other tick species received Nieto -
DSHS Arbovirus Activity 061817
Arbovirus Activity in Texas 2017 Surveillance Report June 2018 Texas Department of State Health Services Infectious Disease Control Unit Zoonosis Control Branch Overview Viruses transmitted by mosquitoes are referred to as arthropod-borne viruses or arboviruses. Arboviruses reported in Texas may include California serogroup viruses (CAL), chikungunya virus (CHIKV), dengue virus (DENV), eastern equine encephalitis virus (EEEV), Saint Louis encephalitis virus (SLEV), western equine encephalitis virus (WEEV), West Nile virus (WNV), and Zika virus (ZIKV), many of which are endemic or enzootic in the state. In 2017, reported human arboviral disease cases were attributed to WNV (54%), ZIKV (22%), DENV (17%), and CHIKV (6%) (Table 1). Animal infections or disease caused by CAL, EEEV, SLEV, and WNV were also reported during 2017. Table 1. Year-End Arbovirus Activity Summary, Texas, 2017 California Serogroup Viruses California serogroup viruses (CAL) are bunyaviruses and include California encephalitis virus (CEV), Jamestown Canyon virus, Keystone virus, La Crosse virus (LACV), snowshoe hare virus, and Trivittatus virus. These viruses are maintained in a cycle between mosquito vectors and vertebrate hosts in forest habitats. In the United States (U.S.), approximately 80-100 reported cases of human neuroinvasive disease are caused by LACV each year (CDC), mostly in mid-Atlantic and southeastern states. From 2002-2016, Texas reported a total of 5 cases of human CAL disease (range: 0-3 cases/year): 1 case of CEV neuroinvasive disease and 4 cases of LACV neuroinvasive disease. In 2017, one CEV-positive mosquito pool was identified in Orange County (Figure 1); no human cases of CAL disease were reported. -
Healthcare Providers, Hospitals, Local Health Departments (Lhds)
May 11, 2015 TO: Healthcare Providers, Hospitals, Local Health Departments (LHDs) FROM: NYSDOH Bureau of Communicable Disease Control HEALTH ADVISORY: TESTING AND REPORTING OF MOSQUITO- AND TICK-BORNE ILLNESSES For healthcare facilities, please distribute immediately to the Infection Control Department, Emergency Department, Infectious Disease Department, Director of Nursing, Medical Director, Laboratory Service, and all patient care areas. The New York State Department of Health (NYSDOH) is advising physicians on the procedures to test and report suspected cases of mosquito-borne illnesses, including West Nile virus (WNV), eastern equine encephalitis (EEE), dengue fever, and chikungunya as well as tick-borne illnesses including Lyme disease, babesiosis, anaplasmosis, ehrlichiosis, and Rocky Mountain spotted fever. SUMMARY Mosquito-borne (arboviral) illnesses: o During the mosquito season (early summer until late fall), health care providers should consider mosquito-borne infections in the differential diagnosis of any adult or pediatric patient with clinical evidence of viral encephalitis or viral meningitis. o All cases of suspected viral encephalitis should be reported immediately to the LHD. o Dengue and/or chikungunya should be suspected year round in patients presenting with fever, arthralgia, myalgia, rash, or other illness consistent with infection and recent travel to endemic areasi. o Wadsworth Center, the NYSDOH public health laboratory, provides testing for a number of domestic, exotic, common and rare viruses. The tests performed will depend on the clinical characteristics, patient status and travel history. Health care providers should contact the LHD of the patient’s county of residence prior to submission of specimens. Tick-borne illnesses: o Tick-borne disease symptoms vary by type of infection and can include fever, fatigue, headache, and rash. -
Zoonoses of Importance in Wildlife Rehabilitation
Zoonoses of Importance in Wildlife Rehabilitation Margaret A. Wild, Colorado Division of Wildlife, 317 W. Prospect Road, Fort Collins, Colorado 80526 W. John Pape, Colorado Department of Public Health and Environment, 4300 Cherry Creek Drive South, Denver, Colorado 80222-1530 Zoonoses are infections or infestations shared in nature by humans and other vertebrate animals. Because wildlife rehabilitators work with animals that have unknown health histories, may be ill, and may be more susceptible to disease due to the stress of captivity, there is a risk of exposure to zoonotic diseases. Although infection of wildlife with most zoonotic diseases is uncommon in Colorado, it is prudent to follow precautions when housing, handling, and treating wild species. In general, most problems can be avoided by using common sense and good hygiene practices. Prevention of infection with zoonotic diseases should be a major emphasis in protocols for rehabilitation of wildlife. In addition to specific control and prevention guidelines listed below for each group of diseases, some general guidelines should be followed in all cases. First, isolation of the wild animal is important both for the animal and to minimize exposure of humans to potential pathogens. Second, good personal hygiene is important. Handwashing after handling animals or animal facilities is extremely important. People should not consume food or drink in the animal facilities. Additional precautions may include wearing protective clothing (lab coat, coveralls), boots, gloves, and/or dust mask depending on the situation. Because children are more susceptible to some zoonotic diseases, particular emphasis should be placed on protecting children. Third, animal facilities and equipment should be kept clean.