DOCSLIB.ORG

(12) Patent Application Publication (10) Pub. No.: US 2017/0156345 A1 HERNANDEZ ROMERO Et Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
(12) Patent Application Publication (10) Pub. No.: US 2017/0156345 A1 HERNANDEZ ROMERO Et Al US 2017.0156345A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0156345 A1 HERNANDEZ ROMERO et al. (43) Pub. Date: Jun. 8, 2017 (54) METHOD FOR A PESTICDE HAVING AN (30) Foreign Application Priority Data INSECTICIDE, ACARICIDE AND NEMATICIDE ACTION BASED ON Sep. 23, 2011 (MX) ................... MXFAf2O11/O1 OO32 ISOQUINOLINE ALKALOIDS AND FLAVONOIDS Publication Classification (51) Int. Cl. (71) Applicant: PROMOTORATECNICA AOIN 65/12 (2006.01) INDUSTRIAL, S.A. DE C.V., Jiutepec AOIN 65/08 (2006.01) (MX) (52) U.S. Cl. (72) Inventors: Yanet Micahela HERNANDEZ CPC ............. A0IN 65/12 (2013.01); A0IN 65/08 ROMERO, Jiutepec, Estado de Mexico (2013.01) (MX); Cristina Margarita (57) ABSTRACT RODRIGUEZ NARVAEZ, Jiutepec, Estado de Mexico (MX); Mario The method for a pesticide having an insecticide, acaricide SAAVEDRA AGUILAR, Jiutepec, and nematicide action is obtained from plant extracts that Estado de Mexico (MX) have important synergic interactions in pesticide activity. The characteristics of the pesticide are efficient control of insects, mites and nematodes, low toxicity for mammals and (21) Appl. No.: 15/014,817 low persistence in the environment. This pesticide is a composition based on plant extracts containing isoquinoline (22) Filed: Feb. 3, 2016 alkaloids and their derivatives (0.1-20%) and flavonoids and their glycosylated derivatives (0.001-10%). Therefore, the field of the invention is generally organic pesticides and in Related U.S. Application Data particular to obtaining an organic pesticide which contains, (63) Continuation of application No. 13/636,330, filed on as an active ingredient, a mixture of isoquinoline alkaloids Sep. 5, 2013, now abandoned. and flavonoids to be used to control agricultural pests. US 2017/0156345 A1 Jun. 8, 2017 METHOD FOR A PESTCIDE HAVING AN 0010 Pyrethrum is extracted from the chrysanthemum INSECTICIDE, ACARICIDE AND flowers (Tanacetum cinerarifolium, Asteraceae) and it is a NEMATICIDE ACTION BASED ON mixture of 6 secondary metabolites: pyrethrins I and II, ISOQUINOLINE ALKALOIDS AND cinerin I and II and jasmolins I and II. Pyrethrum is a FLAVONOIDS neurotoxin that causes immediate paralysis in insects because it blocks Voltage sodium channels that depend on BACKGROUND OF THE INVENTION axons. This action mechanism is similar to that of the 0001 1. Field of the Invention organochlorate pesticide DDT, but as opposed to this, pyre 0002 The present invention relates to a pesticide having thrins show moderate toxicity for mammals. In spite of its an insecticide, acaricide and nematicide action which at least immediate action, most of the insects recover, unless pyre includes an isoquinoline alkaloid and at least a flavonoid, thrum is formulated with a synergic agent. Pyrethrum con same produce important synergic interactions in their bio stitutes approximately 80% of the total of commercial logical activity, said invention is efficient to control plagues botanical pesticides in the world. and its main characteristics are: high specificity on target 0011 Essential oils are the main volatile aromatic prin plagues, low toxicity for mammals, low persistence in the ciples of plants, of a complex chemical nature that mainly environment and in which the active ingredients could include terpenoids, where monoterpenes are the biggest come, although not exclusively, from plant extracts. group and the sesquiterpenes appear in a smaller proportion 0003. Likewise, the present invention relates to a manu (these contain 10 and 15 carbon atoms, respectively) and facturing process, consisting of two stages, where the first more rarely diterpenes (20 carbon atoms). Essential oils, stage refers to obtaining and standardizing the active prin mainly monoterpenes are specifically toxic against pest ciples of the pesticide: isoquinoline alkaloids and fla insects due to their neurotoxic mechanism which acts on the vonoids, as well as a second stage related to its commercial octopaminergic receptors in the system which transmits formula. nervous impulses in invertebrates. Essential oils due to their 0004 2. Description of Related Art Including Informa volatile nature probably enter the insect through the respi tion Disclosed Under 37 CFR 1.97 and 37 CFR 1.98. ratory system and at present are mainly used to protect 0005. Historically, the first generation of botanical pes domestic animals and clothes (against moths), and also as ticides dates back to the XIX Century, when some com wood preservatives. pounds of a botanical origin Such as alkaloids, rotenone and 0012 Phytosanitary products of a plant origin in this first rotenoid compounds, pyrethrins and essential oils were generation were substituted by pesticides product of chemi identified. cal synthesis as organochlorate compounds, organophospho 0006 Alkaloids are nitrogenous secondary metabolites, rus and carbamates, which caused severe environmental generally of a basic character and most of these compounds contamination problems and resistance in insects, in addi are biosynthetized from amino acids. Nicotine is an alkaloid tion to harmful effects in non-target organisms. As an answer isolated from the tobacco plant, mainly form Nicotiana to all of these problems a strictly chemical strategy arose tabacum and Nicotiana rustica (Solanaceae), and it is con where the modification of the structure of natural products sidered as a toxic and dangerous pesticide for humans. It is was sought for to obtain compounds that would have better a neurotoxin that specifically acts on the nicotinic cholin pesticide activity and less toxicity for mammals, these ergic receptors by delaying the closing of the Sodium chan search originated pyrethroids. The interest to develop prod nels, this causes paralysis before death. ucts of a plant origin was also importantly renewed, and 0007 Sabadilla is a pesticide obtained from the Schoe chemical ecology emerged where chemists, biochemists, nocaulon officinale seeds. Its active principles are mainly the toxicologists and specialists in plant protection joined efforts cevadine, Veratridine alkaloids, which are esters of a steroi in the research of natural products of a botanical origin to dal alkaloid called Veracevine which are toxic for mammals control pest with a minimum of environmental problems. (DLso 13 mg/kg), but in commercial preparations that This established the rules for the second generation of include it as an active ingredient its concentration is less than botanical pesticides. 1%. The mechanism action of this type of alkaloids is similar 0013 The more detailed study of the relationship to that of pyrethrins. between plants and insects, allowed researches to know that 0008 Ryania is a powder obtained from the Ryania evolution has given plants chemical mediators implied in the speciosa Wood and its activity is attributed to the ryanodine communication between species, same that are known as (<1%), a pyrrole-2-carboxylic ester of a complex diterpene semiochemical compounds which are regarded as non (ryanodol). Ryanodine acts as a pesticide interfering with nutritious compounds produced by an organism that affect calcium release in the muscular tissue causing a sharp behavior or the biology of individuals of the same species muscular contraction which can be followed by paralysis. (pheromones) or of different species (allelochemical mol 0009 Rotenone is an isoflavonoid and the main pesticide ecules). The latter have a series of effects before harmful component of the roots or rhizomes of the tropical legumi insects and are classified according to their mode of action nous Derris, Lonchocarpus and Tephrosia. Most of the as defensive, toxic, repellent or discouraging, antiphago rotenone used at present comes from Lonchocarpus, also stimulant or digestive inhibitors, and attracting Substances, known as cube root. About 44% of rotenone and 22% of among others, and depending on their chemical composition deguelin, another rotenoid is extracted from this root. Rote and intensity they reveal information in respect to the none is a mitochondrial poison which blocks electron trans physiological status of the plant and the stress in which it is portation and prevents the production of energy. Rotenone is and modify behavior or the biology of an organism of toxic for humans (DLso 132 mg/kg) and although commer another species. These molecules generally act at a low dose cial formulations use less toxic levels than those of lethal and have a specific action and their toxicity for mammals is doses, this pesticide has a limited use in agriculture. low. US 2017/0156345 A1 Jun. 8, 2017 0014. This second generation of botanical pesticides acaricide and nematicide action, new and efficient for inte allowed western researches to rediscover neem used in India grated pest management which attack plants, fruits and/or since ancestral times. From the neem tree seeds animals, based on a new mixture of isoquinoline alkaloids (Azadirachta indica, Meliaceae) two kinds of pesticides can and flavonoids from, although not exclusively, plant extracts be obtained: Neem oil (essential oil) and azadirachtin (10 that show important synergic interactions in their pesticide 25%), a limonoid of the meliacine type. Limonoids have activity. mainly been isolated from the Meliaceae (meliacines) and 0021. The isoquinoline alkaloids of the present invention Rutacea (limonoids of citric plants) families. Limonoides may come from, although not exclusively, the Papaveraceae are modified triterpenes or tetranortriterpenoids, highly
Load more

Recommended publications
  • Sensnity of Bacillus Subtilis to Water Soluble Alkaloid Extracts of Chelidonium Majus L
    SENSNITY OF BACILLUS SUBTILIS TO WATER SOLUBLE ALKALOID EXTRACTS OF CHELIDONIUM MAJUS L. (PAPAVERACEA) ROOTS FROM AZORES M. LEONOR PAVAO & RWE. PINTO PAVAO, M. LEUNOR & RUY E. PINTO1995. Sensivity of Bacillus subtilis to water soluble alkaloid extracts from Azores Chelidonium majus L. (Papaveracea) roots. Arquipdago. Life and Marine Sciences 13A: 93-97. Angra do Heroismo. ISSN 0870-658 1. Water soluble alkaloid (WSA) extracts from Chelidonium majus L. (great celandine) roots. growing on uncultivated ground in the Azores. were prepared. The WSA showed antibacterial properties towards Bacillus subtilis. The effect of WSA appeared to be 1/10 of tetracycline. For concentrations lower than 100 @disc, no reproducible sensivity was observed. Chelidonine, protopine and allocryptopine had no action against Bacillus subtilis. Coptisine, which is reported as not exhibiting antibacterial activity, showed activity against Bacillus subtilis in a similar way as sanguinarine and berberine. Chelerythrine was the most active alkaloid (about 40-50% higher than sanguinarine). Sanguinarine and chelerythrine are generally accepted as the alkaloids responsible for the antibacterial properties of Chelidonium latex. Results suggest that, at least for the species existing in the Azores, berberine and coptisine also contribute to that biological activity . PAVAO, M. LEONOR & RUY E. PINTO1995. Sensibilidade de Bacillus subtilis a extractos de alcaldides solliveis em 5gua de raizes de Chelidonium majus L. (Papaveracea) dos Aqores. Arquipdago. Cigncias Biol6gicas e Marinhas 13A: 93- 97. Angra do Heroismo. ISSN 0870-6581. Prepararam-se extractos de alcalbides soltiveis em Agua de raizes de Chelidonium majus L. (celidbnia), colhida em terrenos incultos nos Agores. Estes extractos revelaram possuir propriedades antibacterianas em relagHo a Bacillus subtilis.
    [Show full text]
  • A Systematic Review on Main Chemical Constituents of Papaver Bracteatum
    Journal of Medicinal Plants A Systematic Review on Main Chemical Constituents of Papaver bracteatum Soleymankhani M (Ph.D. student), Khalighi-Sigaroodi F (Ph.D.)*, Hajiaghaee R (Ph.D.), Naghdi Badi H (Ph.D.), Mehrafarin A (Ph.D.), Ghorbani Nohooji M (Ph.D.) Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran * Corresponding author: Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O.Box: 33651/66571, Karaj, Iran Tel: +98 - 26 - 34764010-9, Fax: +98 - 26-34764021 E-mail: [email protected] Received: 17 April 2013 Accepted: 12 Oct. 2014 Abstract Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods.
    [Show full text]
  • Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals Found in Papaver Somniferum
    Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals found in Papaver somniferum Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 (+)-LAUDANIDINE Fruit -- 0 (+)-RETICULINE Fruit -- 0 (+)-RETICULINE Latex Exudate -- 0 (-)-ALPHA-NARCOTINE Inflorescence -- 0 (-)-NARCOTOLINE Inflorescence -- 0 (-)-SCOULERINE Latex Exudate -- 0 (-)-SCOULERINE Plant -- 0 10-HYDROXYCODEINE Latex Exudate -- 0 10-NONACOSANOL Latex Exudate Chemical Constituents of Oriental Herbs (3 diff. books) 0 13-OXOCRYPTOPINE Plant -- 0 16-HYDROXYTHEBAINE Plant -- 0 20-HYDROXY- Fruit 36.0 -- TRICOSANYLCYCLOHEXA NE 0 4-HYDROXY-BENZOIC- Pericarp -- ACID 0 4-METHYL-NONACOSANE Fruit 3.2 -- 0 5'-O- Plant -- DEMETHYLNARCOTINE 0 5-HYDROXY-3,7- Latex Exudate -- DIMETHOXYPHENANTHRE NE 0 6- Plant -- ACTEONLYDIHYDROSANG UINARINE 0 6-METHYL-CODEINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 6-METHYL-CODEINE Fruit -- 0 ACONITASE Latex Exudate -- 32 AESCULETIN Pericarp -- 3 ALANINE Seed 11780.0 12637.0 0.5273634907250652 -- Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 ALKALOIDS Latex Exudate 50000.0 250000.0 ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. 5 ALLOCRYPTOPINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 15 ALPHA-LINOLENIC-ACID Seed 1400.0 5564.0 -0.22115561650586155 -- 2 ALPHA-NARCOTINE Plant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. 17 APOMORPHINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 APOREINE Fruit -- 0 ARABINOSE Fruit ANON.
    [Show full text]
  • Crude Drugs Containing Quinoline, Isoquinoline, And
    CRUDE DRUGS CONTAINING QUINOLINE, ISOQUINOLINE, AND PHENANTHRENE ALKALOIDS Content 1. MACROMORPHOLOGICAL EVAULATION Cinchonae cortex Ipecacuanhae radix Chelidonii herba Papaveris maturi fructus Opium crudum Fumariae herba 2. MICROSCOPICAL TESTS Cross section: Cinchonae cortex Ipecacuanhae radix Powder preparation: Cinchonae cortex 3. PHYSICO-CHEMICAL AND CHEMICAL TESTS Specific alkaloid reactions 3.1. Grahe test (Cinchonae cortex) 3.2. Emetine test (Ipecacuanhae radix) 3.3. Marquis test (Papaveris maturi fructus) 3.4. Meconic acid test (Papaveris maturi fructus) 3.5. Chelidonii herba tests (Chelidonii herba) 3.5.1. Chelidonic acid test (Chelidonii herba) 3.5.2. Quaternary amine test (Chelidonii herba) 3.5.3. Chromotropic acid test (Chelidonii herba) 3.5.4. Chelidonii herba alkaloid investigation with TLC 4. QUANTITATIVE DETERMNATIONS 4.1. Determination of alkaloid content in Cinchonae cortex (Ph.Eur.) 4.2 Quantitative determination of morphine in ripped capsules of poppy by TLC 1 1. MACROMORPHOLOGICAL EVALUATION Cinchonae cortex Cinchona bark Cinchona pubescens Vahl. Rubiaceae (Cinchona succirubra Pavon) C. calisaya (Weddell) C. ledgeriana (Moens ex Trimen) Ph. Eur. Whole or cut, dried bark of Cinchona species. Content: minimum 6.5 per cent of total alkaloids, of which 30 %- 60 % consists of quinine type alkaloids (dried drug). Ipecacuanhae radix Ipecacuanha root Cephaelis ipecacuanha (Brot.) A.Rich. Rubiaceae Cephaelis acuminata Karsten Ph. Eur. Karlten Ipecacuanha root consists of the fragmented and dried underground organs of Cephaelis species. It contains not less than 2.0 per cent of total alkaloids, calculated as emetine. The principal alkaloids are emetine and cephaeline. Chelidonii herba Greater Celandine Chelidonium majus L. Papaveraceae Ph.Eur. Dried, whole or cut aerial parts of Chelidonium majus L collected during flowering.
    [Show full text]
  • Argemone Ochroleuca: (PAPAVERACEAE), ALKALOID POTENTIAL SOURCE for AGRICULTURAL and MEDICINAL USES †
    Tropical and Subtropical Agroecosystems 23 (2020): #31 Hernández-Ruiz et al., 2020 Review [Revisión] Argemone ochroleuca: (PAPAVERACEAE), ALKALOID POTENTIAL SOURCE FOR AGRICULTURAL AND MEDICINAL USES † [Argemone ochroleuca: (PAPAVERACEAE), FUENTE POTENCIAL DE ALCALOIDES PARA LA AGRICULTURA, Y USO MEDICINAL] J. Hernández-Ruiz1, J. Bernal2, J. Gonzales-Castañeda1, J. E. Ruiz-Nieto1 and A. I. Mireles-Arriaga1* 1División de Ciencias de la Vida, Universidad de Guanajuato. Km 9 carretera Irapuato-Silao, Ex Hacienda. El Copal, Irapuato, Guanajuato. 36500 México. Email: [email protected] 2Department of Entomology, Texas A&M University, College Station, TX 77843-247, USA *Corresponding author SUMMARY Background. The genus Argemone contains 24 species, A. ochorleuca is present in national territory and is used in agriculture and traditional medical treatments for various conditions. Results. A. ochorleuca is an herbaceous and/or perennial plant that blooms all year. This plant had the potential as a source of benzyl isoquinoline alkaloids, which are the main bioactive compounds responsible for antibacterial, antifungal properties. However, some of these compounds are associated with toxic effects too. Information about concentrations and parts of the plant it is important for all uses and applications. Implications. The present work summarizes available information on phytochemical and medicinal properties. Conclusion. In A. ochrolecuca, six of the 45 alkaloids reported for the genus Argemone have been studied, dihydro-keleritrin and dihydro-sanguiranine are the most abundant in the seeds and vegetative tissue of the species. The updated information should be useful to guide future research on this plant. Keywords: Alkaloids; papaveraceae; berberine; sanguinarine. RESUMEN Antecedentes. El género Argemone contiene 24 especies, A.
    [Show full text]
  • Plant Profile, Phytochemistry and Pharmacology of Argemone Mexicana Linn
    Innovare International Journal of Pharmacy and Pharmaceutical Sciences Academic Sciences ISSN- 0975-1491 Vol 6, Issue 7, 2014 Review Article PLANT PROFILE, PHYTOCHEMISTRY AND PHARMACOLOGY OF ARGEMONE MEXICANA LINN. A REVIEW REKHA SHARANAPPA, VIDYASAGAR G. M.* Medicinal Plants and Microbiology Research Laboratory, Department of Post-Graduate Studiesand Research in Botany, Gulbarga University, Gulbarga-585106, Karnataka, India. Email: [email protected] Received: 02 June 2014 Revised and Accepted: 13 Jul 2014 ABSTRACT Argemone Mexicana is extensively used as traditional medicine for the treatment of numerous diseases. Various parts of the plant were extensively used in Ayurveda, Siddha, Unani and Homeopathic medicines. It is reported to have antimicrobial activity, wound healing property, larvicidal and chemosterilant activity, nematicidal and allelopathic potential, antimalarial, antibacterial and antifungal, molluscicidal, anticancer, hepatoprotective, anti-HIV and neuropharmacological activity. Chemical investigations of this plant have revealed the presence of alkaloids, amino acids, phenolics and fatty acids. A. mexicana has shown promise as an effective bio-control agent. The present review includes the detailed exploration of traditional uses, phytochemical and pharmacological properties and actions of whole plant extract reported so far. Keywords: Plant Profile, Phytochemistry, Pharmacology, Biological activity, Argemone mexicana, Toxicity, Safety Evaluation. INTRODUCTION review and compile updated information on various aspects of A. mexicana, a plant used all over the world. Plants have been used in medicines since time immemorial. India has a rich heritage of using medicinal plants in traditional medicines, Habitat as in the Ayurveda, Siddha and Unani systems besides folklore practices. The earliest inscription of the medicinal uses of plants is A. mexicana is native of tropical America which has distributed in found in the “Rigveda”, which is one of the oldest repositories of tropical and subtropical regions of the World.
    [Show full text]
  • Argemone Mexicana. Methods of Treatment and Prevention of Epidemic Dropsy Are Described
    National Ribat University Faculty of Graduate Studies and Scientific Researches Behavioral pharmacology study on Argemone Mexicana L. seed in Sudan A dissertation submitted for the partial fulfillment of the degree of MSc. In forensic sciences By:Bayan Osman Mustafa Abd Allah Supervised by:Prof. Yahia M.A.Elimam 2016 I بسم اهلل الرحمن الرحيم ِ ِ ِ " أَلم تر أن اهلل أنزل من السماء ماء فأخرناا ب ممرا ٍ َِ َِ َِ َِ ِ ِ َِ َِ ِ َِ ِ ِ َ َِ ِ ِ ِ مختلفا ألوانها و من الجبال ندد بيض و حمر مختلف ِ ِ ِ ِ ِ َِ ِ ِ ِ ِ ِ ِ ِ َ ألوانها و غرابيب سود * و من اﻻاس و الدواب و األنعام ِ ِ َِ ِ ِ ِ َِ َ َِ ِ ِ َِ ِ ِ ِ مختلف ألوا ن كذلك إنما يخشى اهلل من ِ با د العل ما ِ َِ ِ ِ ِ َ َِ ِ َِ ِ ِ ِ ِ ِ ِ َِ َ َ ِ َ إن اهلل زيز غفور " ف اطر 28-27 َِ ِ َِ َِ ِ َ ِ ِ صدق اهلل العظيم I Dedication Every challenging work needs self-efforts as well as guidance of elders especially those who were very close to our heart, My humble effort I dedicate to my sweet and loving Mother and Father, Whose affection, love, encouragement and prays of day and night make me able to get such success and honor.. II Acknowledgment First of all, I am grateful to Allah for establishing me to complete this thesis.
    [Show full text]
  • Chemo-Dahlgrenogram of the Tribe Papavereae
    Chemo-Dahlgrenogram of the Tribe Papavereae P. Tétényi Research Institute of Medicinal Plants P.O. Box 11 2011 Budakalász Hungary Keywords: chemotaxonomy, Romneya, Cathcartia, Meconopsis, Stylomecon, Roemeria Abstract The review puts forward and extends the chemo-dahlgrenogram of the genus Papaver over Papavereae. — Tertiary Cathcartia owns watery latex as Romneya (Pa- laeoaster’s sister), but is evoluted by sole sand-like crystals in seeds’ coats. On the other hand, Cathcartia, that synthesizes indenobenzoazepine alkaloids, differs sub- stantially from Meconopsis. Therefore Cathcartia is an independent entity represent- ing the starting-point for Papavereae. — Meconopsis cambrica Vig. is missing Me- conopsis constituents mentioned before, but synthesizes armepavine derivative aporphines, as well as meconic acid and nudicaulin (stated at Papaver sections, but being unproved at Meconopsis taxa). Therefore the species belongs to Papaver genus, and its original name Papaver cambricum Linnaeus is effective again. — Meconopsis polycarpic (sometimes monocarpic) species of ser. Simplicifoliae accumulate retro- protoberberines, but ser. Grandes only berberine. Monocarpic species of Aculeatae and Robustae are characterized by isopavines, orientaline derivative aporphines and harmane alkaloids. Monocarpic life span of Meconopsis taxa is analogous with the biennial Papaver sect. Meconidium. — Separation of the Californian, annual Sty- lomecon heterophylla with phthalideisoquinoline alkaloid content from the Asian ge- nus Meconopsis is also proved, alike to some annual or biennial Papaver taxa. — Roemeria species with aporphines and protoberberines are joined to Papaver section Argemonidium. Chemism of Roemeria refracta with rhoeadanes, promorphinanes is more similar to Papaver genus, in contrast to R. hybrida synthesizing spirocyclic- coupled proaporphines, unique at Papavereae. — The previous Papaver chemo- dahlgrenogram must be changed by detaching sect.
    [Show full text]
  • Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals Found in Papaver Somniferum
    Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals found in Papaver somniferum Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 (+)-LAUDANIDINE Fruit -- 0 (+)-RETICULINE Fruit -- 0 (+)-RETICULINE Latex Exudate -- 0 (-)-ALPHA-NARCOTINE Inflorescence -- 0 (-)-NARCOTOLINE Inflorescence -- 0 (-)-SCOULERINE Latex Exudate -- 0 (-)-SCOULERINE Plant -- 0 10-HYDROXYCODEINE Latex Exudate -- 0 10-NONACOSANOL Latex Exudate Chemical Constituents of Oriental Herbs (3 diff. books) 0 13-OXOCRYPTOPINE Plant -- 0 16-HYDROXYTHEBAINE Plant -- 0 20-HYDROXY- Fruit 36.0 -- TRICOSANYLCYCLOHEXA NE 0 4-HYDROXY-BENZOIC- Pericarp -- ACID 0 4-METHYL-NONACOSANE Fruit 3.2 -- 0 5'-O- Plant -- DEMETHYLNARCOTINE 0 5-HYDROXY-3,7- Latex Exudate -- DIMETHOXYPHENANTHRE NE 0 6- Plant -- ACTEONLYDIHYDROSANG UINARINE 0 6-METHYL-CODEINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 6-METHYL-CODEINE Fruit -- 0 ACONITASE Latex Exudate -- 32 AESCULETIN Pericarp -- 3 ALANINE Seed 11780.0 12637.0 0.5273634907250652 -- Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 ALKALOIDS Latex Exudate 50000.0 250000.0 ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. 5 ALLOCRYPTOPINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 15 ALPHA-LINOLENIC-ACID Seed 1400.0 5564.0 -0.22115561650586155 -- 2 ALPHA-NARCOTINE Plant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. 17 APOMORPHINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 APOREINE Fruit -- 0 ARABINOSE Fruit ANON.
    [Show full text]
  • Molecular Geometry of Alkaloids Present in Seeds of Mexican Prickly Poppy
    MOLECULAR GEOMETRY OF ALKALOIDS PRESENT IN SEEDS OF MEXICAN PRICKLY POPPY Ricardo Gobato [[email protected]] Secretaria de Estado da Educação do Paraná (SEED/PR) Av. Maringá, 290, Jardim Dom Bosco, Londrina/PR, 86060-000, Brasil. Desire Francine Gobato Fedrigo [[email protected]] Panoramic Residence, Rua Uruguai, 1380, ap. 405, Parque Jardim America, Centro, Londrina/PR, 86010-210, Brasil Alekssander Gobato [[email protected]] Faculdade Pitágoras Londrina Rua Edwy Taques de Araújo, 1100, Gleba Palhano, Londrina/PR, 86047-500, Brasil. ABSTRACT The work is a study of the geometry of the molecules via molecular mechanics of the main alkaloids found in the seeds of Argemone Mexicana Linn, a prickly poppy, which is considered one of the most important species of plants in traditional Mexican and Indian medicine system. The seeds have toxic properties as well as bactericide, hallucinogenic, fungicide, insecticide, in isoquinolines and sanguinarine alkaloids such as berberine. A computational study of the molecular geometry of the molecules through molecular mechanics of the main alkaloids compounds present in plant seeds is described in a computer simulation. The plant has active ingredients compounds: allocryptopine, berberine, chelerythrine, copsitine, dihydrosanguinarine, protopine and sanguinarine. The studied alkaloids form two groups having similar charge distribution among themselves, which have dipole moments of these two times higher than in the other group. Keywords: Alkaloids, Argemone Mexicana Linn, Bactericidal, Fungicide, Hallucinogenic, Insecticide, Molecular Geometry, Prickly Poppy, Toxic. Contents 3.5 Dihydrosanguinarine . 6 3.6 Protopine . 6 Introduction 1 3.7 Sanguinarine . 6 1 The plant 2 4 Discussion and conclusions 6 1.1 Argemone Mexicana Linn .
    [Show full text]
  • Manuscript for in VITRO Cellular & Developmental Biology PLANT
    Supplementary Figure 1. HPLC chromatograms of the authentic standards (A) and the methanol extracts from the dried latex of P. somniferum WT plant (B) and the representative transformants (C to F). 0.20 32.913 29.861 27.001 27.893 33.899 36.868 20.854 – – – – – – – 0.15 11.972 – Thebaine 0.10 Coptisine Palmatine Berberine Papaverine - 24.958 AU Morphine - 7.308 Columbamine Oripavine Sanguinarine Isothebaine - 18.134 [AU] Jateorrhizine Reticuline - 14.262 0.05 Noscapine - 26.093 Methylcodeine - 15.384 Magnoflorine - 13.756 Codeine - 9.847 0.00 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 [min][min]分 (A) Standards 0.08 0.06 0.04 AU [AU] 0.02 Noscapine - 26.016 Morphine - 7.294 Papaverine - 25.093 Codeine - 9.843 0.00 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 [min]分 (B) WT1 0.14 0.12 20.732 – 0.10 0.08 Thebaine AU [AU] 0.06 0.04 0.02 Papaverine - 25.051 Noscapine - 25.992 Codeine - 9.821 Morphine - 7.246 0.00 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 分 [min] (C) T1 #1-27(HT) 0.14 0.12 20.744 – 0.10 0.08 Thebaine AU [AU] 0.06 0.04 0.02 Noscapine - 26.009 Papaverine - 25.063 Morphine - 7.264 Codeine - 9.836 0.00 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 分 [min] (D) T1 #2-17(HT) 0.20 0.15 AU 0.10 [AU] Morphine - 7.295 0.05 Noscapine - 25.976 Papaverine - 25.076 Codeine - 9.854 Thebaine - 20.898 0.00 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 [min]分 (E) T1 #2-1(LT) 0.050 0.040 0.030 AU [AU] 0.020 Noscapine - 26.055 0.010 Morphine - 7.178 Papaverine - 25.112 Thebaine - 20.907 Codeine - 9.822 0.000 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 20.00 22.00 24.00 26.00 28.00 30.00 32.00 34.00 36.00 38.00 40.00 [min]分 (F) T1 #2-6(LT) Supplementary Table 1.
    [Show full text]
  • Effects of Chelidonium Majus Extracts and Major Alkaloids on Herg Potassium Channels and on Dog Cardiac Action Potential — a Safety Approach
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Repository of the Academy's Library Fitoterapia 100 (2015) 156–165 Contents lists available at ScienceDirect Fitoterapia journal homepage: www.elsevier.com/locate/fitote Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential — A safety approach Péter Orvos a,b,LászlóVirága,LászlóTálosib, Zsuzsanna Hajdú c,Dezső Csupor c, Nikoletta Jedlinszki c, Tamás Szél a,AndrásVarróa,d, Judit Hohmann c,⁎ a Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Dóm tér 12, H-6720 Szeged, Hungary b Rytmion Ltd., Benczúr u. 39, H-6727 Szeged, Hungary c Department of Pharmacognosy, University of Szeged, Faculty of Pharmacy, Eötvös u. 6, H-6720 Szeged, Hungary d MTA-SZTE Cardiovascular Pharmacology Research Group, Hungarian Academy of Sciences, Dóm tér 12, H-6720 Szeged, Hungary article info abstract Article history: Chelidonium majus or greater celandine is spread throughout the world, and it is a very common Received 3 October 2014 and frequent component of modern phytotherapy. Although C. majus contains alkaloids with Accepted in revised form 21 November 2014 remarkable physiological effect, moreover, safety pharmacology properties of this plant are not Accepted 26 November 2014 widely clarified, medications prepared from this plant are often used internally. In our study the Available online 4 December 2014 inhibitory effects of C. majus herb extracts and alkaloids on hERG potassium current as well as on cardiac action potential were investigated. Our data show that hydroalcoholic extracts of greater Chemical compounds studied in this article: celandine and its alkaloids, especially berberine, chelidonine and sanguinarine have a significant Berberine (PubChem CID: 2353) hERG potassium channel blocking effect.
    [Show full text]