Phytochemical Composition and Antimicrobial Activity of Corydalis Solida and Pseudofumaria Lutea
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Sensnity of Bacillus Subtilis to Water Soluble Alkaloid Extracts of Chelidonium Majus L
SENSNITY OF BACILLUS SUBTILIS TO WATER SOLUBLE ALKALOID EXTRACTS OF CHELIDONIUM MAJUS L. (PAPAVERACEA) ROOTS FROM AZORES M. LEONOR PAVAO & RWE. PINTO PAVAO, M. LEUNOR & RUY E. PINTO1995. Sensivity of Bacillus subtilis to water soluble alkaloid extracts from Azores Chelidonium majus L. (Papaveracea) roots. Arquipdago. Life and Marine Sciences 13A: 93-97. Angra do Heroismo. ISSN 0870-658 1. Water soluble alkaloid (WSA) extracts from Chelidonium majus L. (great celandine) roots. growing on uncultivated ground in the Azores. were prepared. The WSA showed antibacterial properties towards Bacillus subtilis. The effect of WSA appeared to be 1/10 of tetracycline. For concentrations lower than 100 @disc, no reproducible sensivity was observed. Chelidonine, protopine and allocryptopine had no action against Bacillus subtilis. Coptisine, which is reported as not exhibiting antibacterial activity, showed activity against Bacillus subtilis in a similar way as sanguinarine and berberine. Chelerythrine was the most active alkaloid (about 40-50% higher than sanguinarine). Sanguinarine and chelerythrine are generally accepted as the alkaloids responsible for the antibacterial properties of Chelidonium latex. Results suggest that, at least for the species existing in the Azores, berberine and coptisine also contribute to that biological activity . PAVAO, M. LEONOR & RUY E. PINTO1995. Sensibilidade de Bacillus subtilis a extractos de alcaldides solliveis em 5gua de raizes de Chelidonium majus L. (Papaveracea) dos Aqores. Arquipdago. Cigncias Biol6gicas e Marinhas 13A: 93- 97. Angra do Heroismo. ISSN 0870-6581. Prepararam-se extractos de alcalbides soltiveis em Agua de raizes de Chelidonium majus L. (celidbnia), colhida em terrenos incultos nos Agores. Estes extractos revelaram possuir propriedades antibacterianas em relagHo a Bacillus subtilis. -
GRANADA FEI Passport No: 104DK01/ITA
DECISION of the FEI TRIBUNAL dated 14 July 2017 Positive Anti-Doping Case No.: 2016/BS09 Horse: GRANADA FEI Passport No: 104DK01/ITA Person Responsible/NF/ID: Allegra Ieraci/ITA/10097333 Represented by: Studio Legale Avv. Claudio Brugnatelli, Strada Nuova n. 53, 27100 Pavia, Italy Event/ID: CSI3*-W – El Jadida (MAR) - 2016_CI_0722_S_S_01 Date: 13 – 16 October 2016 Prohibited Substances: Oripavine, Morphine and Codeine I. COMPOSITION OF PANEL Mr. Erik Elstad, one member panel II. SUMMARY OF THE FACTS 1. Memorandum of case: By Legal Department. 2. Summary information provided by Person Responsible (PR): The FEI Tribunal duly took into consideration all evidence, submissions and documents presented in the case file, as well as during the oral hearing, as also made available by and to the PR. 3. Oral hearing: 6 July 2017 – via telephone conference call. Present: The FEI Tribunal Panel Ms. Erika Riedl, FEI Tribunal Clerk For the PR: Mr. Claudio Brugnatelli, Legal Counsel Mr. Giovanni Ieraci, PR’s father Page 1 of 19 For the FEI: Ms. Anna Thorstenson, FEI Legal Counsel III. DESCRIPTION OF THE CASE FROM THE LEGAL VIEWPOINT 1. Articles of the Statutes/Regulations which are applicable: Statutes 23rd edition, effective 29 April 2015 (“Statutes”), Arts. 1.4, 38 and 39. General Regulations, 23rd edition, 1 January 2009, updates effective 1 January 2016, Arts. 118, 143.1, 161, 168 and 169 (“GRs”). Internal Regulations of the FEI Tribunal, 2nd edition, 1 January 2012 (“IRs”). FEI Equine Anti-Doping and Controlled Medication Regulations ("EADCMRs"), 2nd edition, effective 1 January 2016. FEI Equine Anti-Doping Rules ("EAD Rules"), 2nd edition, effective 1 January 2016. -
Květy Nebo Větve Květenství • Téměř Vždy Bez Palistů (Drobné Úkrojky Čepele Na Bázi Listů U Krytosemenných Rostlin
Ranunculaceae (pryskyřníkovité) Oddělení: Angiospermae (Magnoliophyta) Dvouděložné (Dicots) Bazální dvouděložné Řád: Ranunculales Čeleď: Ranunculaceae Ranunculaceae – pryskyřníkovité Ranunculus acris • Převážně suchozemské byliny (pryskyřník prudký) • Listy až na výjimky střídavé nebo v přízemní růžici často členěné nebo složené • nebo lodyha bezlistá s výraznými metamorfovaný (přeměněný) listeny list, z jehož úžlabí vyrůstají listy střídavé květy nebo větve květenství • téměř vždy bez palistů (drobné úkrojky čepele na bázi listů u krytosemenných rostlin. Existují volné (přirostlé) k řapíku (vikve, violky, hrách), opadavé (jabloň), přeměněné v trny (trnovník akát) listeny • Časté alkaloidy list nebo glykosidy bezlistá lodyha Anemone nemorosa (sasanka hajní) www.zum.de/stueber/lindman/ Ranunculaceae – pryskyřníkovité •Květy: aktinomorfní i zygomorfní květní obaly nedokonale rozlišené, volné •Květenství: hroznovité nebo květy jednotlivé Anemone ranunculoides Aconitum variegatum (sasanka pryskyřníkovitá) (oměj pestrý) květ jednolivý aktinomorfní zygomorfní květ hroznovité květenství Ranunculaceae – pryskyřníkovité •Květy: oboupohlavné, zpravidla spirocyklické tyčinek mnoho gyneceum apokarpní (plodolistů často mnoho nebo redukce až na 1) svrchní •Plod: měchýřek, nažka nebo bobule Ranunculus bulbosus (pryskyřník hlíznatý) nažka koruna plodolisty kalich tyčinky Ranunculaceae – pryskyřníkovité Naši zástupci Ranunculus acris (pryskyřník prudký) Ranunculus repens (pryskyřník plazivý) Ranunculaceae – pryskyřníkovité Anemone ranunculoides Anemone -
Anticancer Effects of NSC‑631570 (Ukrain) in Head and Neck Cancer Cells: in Vitro Analysis of Growth, Invasion, Angiogenesis and Gene Expression
282 ONCOLOGY REPORTS 43: 282-295, 2020 Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression RUTH HERRMANN1, JOSEPH SKAF2, JEANETTE ROLLER1, CHRISTINE POLEDNIK1, ULRIKE HOLZGRABE2 and MARIANNE SCHMIDT1 1Department of Otorhinolaryngology, University of Würzburg, D-97080 Würzburg; 2Institute of Pharmacy and Food Chemistry, University of Würzburg, D-97074 Würzburg, Germany Received September 17, 2018; Accepted September 30, 2019 DOI: 10.3892/or.2019.7416 Abstract. NSC-631570 (Ukrain) is an aqueous extract of laminin). Microarray analysis revealed the downregulation of Chelidonium majus, a herbaceous perennial plant, one of two genes encoding key regulators, including EGFR, AKT2, JAK1, species in the genus Chelidonium, which has been demonstrated STAT3 and ß-catenin (CTNNB1), all of which are involved in to selectively kill tumor cells without affecting non-malignant cell proliferation, migration, angiogenesis, apoptosis as well as cells. In the present study, the components of NSC-631570 the radiation- and chemo-resistance of HNSCC. The strongest were examined by combined liquid chromatography/mass upregulation occurred for cytochrome P450 1A1 (CYP1A1) spectroscopy (LC-MS) and the effects of NSC-631570 on and 1B1 (CYP1B1), involved in the metabolism of xenobiotics. HNSCC cell lines, as well as primary cells, were analyzed Upregulation of CYP1A1 was at least partially caused by chel- with respect to growth, apoptosis, invasion, angiogenesis erythrine and allocryptopine, as shown by RT-qPCR in two and gene expression. LC-MS identified chelerythrine and HNSCC cell lines. In addition, NSC-631570 showed a high allocryptopine as the major alkaloids of the extract. -
Draft Assessment Report on Chelidonium Majus L., Herba
25 November 2010 EMA/HMPC/369801/2009 Committee on Herbal Medicinal Products (HMPC) Assessment report on Chelidonium majus L., herba Based on Article 10a of Directive 2001/83/EC as amended (well-established use) Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) Draft Herbal substance(s) (binomial scientific name of Chelidonium majus L. the plant, including plant part) Dried whole or cut aerial parts of the plant Herbal preparation(s) Internal Use a) Chelidonii herba: comminuted b) Chelidonii tincture: 1:10 ethanol 45% (V/V) c) Chelidonii extractum fluidum: 1:1 ethanol 25% (V/V) d) Chelidonii extractum siccum (concentration not specified) e) Chelidonium majus mother tincture (M.T. (ø)) External Use a) Eye-drops: (preparation not specified) b) Ointment: (concentration not specified) Pharmaceutical forms Herbal preparation in solid or liquid dosage form or as a herbal tea for oral use. Herbal preparation in solid or liquid dosage form for external use. Rapporteur Assessor(s) 7 Westferry Circus ● Canary Wharf ● London E14 4HB ● United Kingdom Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7051 E-mail [email protected] Website www.ema.europa.eu An agency of the European Union © European Medicines Agency, 2011. Reproduction is authorised provided the source is acknowledged. Note: This Assessment Report is published to support the release for public consultation of the draft Community herbal monograph on Chelidonium majus L. It should be noted that this document is a working document, not yet fully edited, and which shall be further developed after the release for consultation of the monograph. -
Czech Forest (Site) Ecosystem Classification
Czech Forest (Site) Ecosystem Classification Jiří Viewegh 1 Introduction Ecosystem (site) classification of forests in Czech Republic is among those based on environmental factors. Initially, it was developed using a phytosociologal basis, but later, in view of operational application, the emphasis was placed on the environment of forest ecosystems. Climatic and soil studies helped to characterize environmental conditions and their relationships to forest communtieis. As the development of a true ecological classification is difficult, existing forest ecosystem classifications are driven either by vegetation or environment. These two different approaches influenced the development of forest classification (commonly referred to as forest typology) in former Czechoslovakia. "Typological System of Forest Management Planning Institute" is the name of a recently established forest site classification. Taking into consideration extensive changes in forest cover, which have resulted in profiound changes in forest communities and the associated forest floor and soil properties (degradation stages), the classification system is based upon relatively stable environmental conditions. In addition to characterizing humus forms and plant communities of climax (potential) vegetation, the systen also attempts to quantify potential production of forest ecosystems (e.g., yield class and canopy position of trees). This typological system, which was developed by Plíva and Průša (Plíva 1971-1976) has been applied in Czech forests since 1970. As the composition of most of the original forests was changed to Norway spruce (Picea abies) monocultures in last 200 years, two environmental (site) factors were used in organizing the system. These are soil and climatic properties, the latter are represented by forest vegetation zones which express altitudinal zonation of forest vegetation in Czech Republic. -
Effects of Berberine, Chelerythrine, and Sanguinarine on Proliferation in Four Human Immortalized Cell Lines
Journal of the Iowa Academy of Science: JIAS Volume 119 Number 1-4 Article 6 2012 Effects of Berberine, Chelerythrine, and Sanguinarine on Proliferation in Four Human Immortalized Cell Lines David S. Senchina Drake University Nisarg B. Shah Drake University Marc G. Busch Drake University Let us know how access to this document benefits ouy Copyright © Copyright 2014 by the Iowa Academy of Science, Inc. Follow this and additional works at: https://scholarworks.uni.edu/jias Part of the Anthropology Commons, Life Sciences Commons, Physical Sciences and Mathematics Commons, and the Science and Mathematics Education Commons Recommended Citation Senchina, David S.; Shah, Nisarg B.; and Busch, Marc G. (2012) "Effects of Berberine, Chelerythrine, and Sanguinarine on Proliferation in Four Human Immortalized Cell Lines," Journal of the Iowa Academy of Science: JIAS, 119(1-4), 22-27. Available at: https://scholarworks.uni.edu/jias/vol119/iss1/6 This Research is brought to you for free and open access by the Iowa Academy of Science at UNI ScholarWorks. It has been accepted for inclusion in Journal of the Iowa Academy of Science: JIAS by an authorized editor of UNI ScholarWorks. For more information, please contact [email protected]. Jour. Iowa Acad. Sci. 119(1--4):22-27, 2012 Effects of Berberine, Chelerythrine, and Sanguinarine on Proliferation in Four Human Immortalized Cell Lines DAVIDS. SENCHINA1·*, NISARG B. SHAH2 and MARC G. BUSCH 1 1Deparcmenc of Biology, Drake University, Des Moines, IA 2Pharmacy Program, Drake University, Des Moines, IA Bloodroot (Sanguinaria canadensis L., Papaveraceae) is a plane rich in benzophenanchridine (isoquinoline) alkaloids ~uch_ as sanguinarine and chelerychrine. -
A Systematic Review on Main Chemical Constituents of Papaver Bracteatum
Journal of Medicinal Plants A Systematic Review on Main Chemical Constituents of Papaver bracteatum Soleymankhani M (Ph.D. student), Khalighi-Sigaroodi F (Ph.D.)*, Hajiaghaee R (Ph.D.), Naghdi Badi H (Ph.D.), Mehrafarin A (Ph.D.), Ghorbani Nohooji M (Ph.D.) Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran * Corresponding author: Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, P.O.Box: 33651/66571, Karaj, Iran Tel: +98 - 26 - 34764010-9, Fax: +98 - 26-34764021 E-mail: [email protected] Received: 17 April 2013 Accepted: 12 Oct. 2014 Abstract Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. -
Argemone Mexicana
Argemone mexicana General description Scientific Name with Author Argemone mexicana L. Synonyms Argemone leiocarpa Greene; Argemone ochroleuca Sweet; Echtrus trivialis Lour.; Echtrus mexicanus (L.) Nieuwl.; Argemone vulgaris Spach; Argemone versicolor Salisb.; Argemone spinosa Moench; Argemone sexvalis Stokes; Argemone mucronata Dum. Cours. ex Steud.; Argemone mexicana var. typica Prain; Argemone mexicana var. parviflora Kuntze; Argemone mexicana var. ochroleuca (Sweet) Lindl.; Argemone mexicana var. lutea Kuntze; Argemone mexicana fo. leiocarpa (Greene) G.B. Ownbey (Pires, 2009). Family Papaveraceae Vernacular Names Mexican poppy, prickly poppy, yellow thistle, Mexican thistle (En). Argémone, pavot épineux, pavot du Mexique, tache de l’œil, chardon du pays (Fr) (Bosch, 2008) Botanical Description Argemone mexicana is an annual herb, growing up to 150 cm with a slightly branched tap root. Its stem is branched and usually extremely prickly. It exudes a yellow juice when cut. It has showy yellow flowers. Leaves are thistle-like and alternate, without leaf stalks (petioles), toothed (serrate) and the margins are spiny. The grey-white veins stand out against the bluish-green upper leaf surface. The stem is oblong in cross-section. Flowers are at the tips of the branches (are terminal) and solitary, yellow and of 2.5-5 cm diameter. Fruit is a prickly oblong or egg-shaped (ovoid) capsule. Seeds are very numerous, nearly spherical, covered in a fine network of veins, brownish black and about 1 m m in diameter (Nacoulma, 1996; Bosch, 2008). 1 MEAMP – Appear Project – 75 September 2012 – August 2014 Photo LABIOCA 1. Argemone mexicana Origin and Distribution Argemone mexicana is native in Mexico and the West Indies, but has become pantropical after accidental introduction or introduction as an ornamental. -
Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders
REVIEW published: 21 August 2018 doi: 10.3389/fphar.2018.00557 Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders Maria A. Neag 1, Andrei Mocan 2*, Javier Echeverría 3, Raluca M. Pop 1, Corina I. Bocsan 1, Gianina Cri¸san 2 and Anca D. Buzoianu 1 1 Department of Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, 2 Department of Pharmaceutical Botany, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, 3 Department of Environmental Sciences, Universidad de Santiago de Chile, Santiago de Chile, Chile Edited by: Berberine-containing plants have been traditionally used in different parts of the world for Anna Karolina Kiss, the treatment of inflammatory disorders, skin diseases, wound healing, reducing fevers, Medical University of Warsaw, Poland affections of eyes, treatment of tumors, digestive and respiratory diseases, and microbial Reviewed by: Pinarosa Avato, pathologies. The physico-chemical properties of berberine contribute to the high diversity Università degli Studi di Bari Aldo of extraction and detection methods. Considering its particularities this review describes Moro, Italy various methods mentioned in the literature so far with reference to the most important Sylwia Zielinska, Wroclaw Medical University, Poland factors influencing berberine extraction. Further, the common separation and detection *Correspondence: methods like thin layer chromatography, high performance liquid chromatography, and Andrei Mocan mass spectrometry are discussed in order to give a complex overview of the existing [email protected] methods. Additionally, many clinical and experimental studies suggest that berberine Specialty section: has several pharmacological properties, such as immunomodulatory, antioxidative, This article was submitted to cardioprotective, hepatoprotective, and renoprotective effects. -
By HENRYDEANE, F.L.S., and HENRYB
View Article Online / Journal Homepage / Table of Contents for this issue 34 DEASE AND BRADY ON MICROSCOPICAL VIIP.-On ikIicroscopicu2 Research in relation to Pharmacy. By HENRYDEANE, F.L.S., and HENRYB. BRADY,F.L.S. [Read at the Bath Meeting of the British Pharmaceutical Conference, Sept., 1864.1 WE have chosen for the particular subject of the present commu- nication the various preparations of opium. Whether regarded in respect to their importance in the practice of medicine, their variability in strength and character, or the peculiar conditions in which the active matter exists in the crude drug, no better subject could be found for the purpose in view. Opium, as is well known, is an extremely composite substance, being a pasty mass formed of resinous, gummy, extractive and albuminous matters, containing a larger or srrialler percentage of certain active principles diffused through it. These principles are morphine, narcotine (with its two homologuesj, codeine, narceine, mecoiiine, thellaine, and papaverine, either existing free or in com- bination with meconic, sulphuric, or other acids, the sum of the crystalline constituents, exclusive of inorganic salts, contained in good samples of the drug, being from twenty to thirty per cent. of its entire weight. Any preparation, exactly to represent opium, must contain the whole of' these principles, as indeed the tincture may be said fairly to do. It, has, however, been shown that some of the principles are inert, and others even deleterious in their action, and we have Published on 01 January 1865. Downloaded by University of Pittsburgh 30/10/2014 05:40:05. -
Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals Found in Papaver Somniferum
Dr. Duke's Phytochemical and Ethnobotanical Databases Chemicals found in Papaver somniferum Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 (+)-LAUDANIDINE Fruit -- 0 (+)-RETICULINE Fruit -- 0 (+)-RETICULINE Latex Exudate -- 0 (-)-ALPHA-NARCOTINE Inflorescence -- 0 (-)-NARCOTOLINE Inflorescence -- 0 (-)-SCOULERINE Latex Exudate -- 0 (-)-SCOULERINE Plant -- 0 10-HYDROXYCODEINE Latex Exudate -- 0 10-NONACOSANOL Latex Exudate Chemical Constituents of Oriental Herbs (3 diff. books) 0 13-OXOCRYPTOPINE Plant -- 0 16-HYDROXYTHEBAINE Plant -- 0 20-HYDROXY- Fruit 36.0 -- TRICOSANYLCYCLOHEXA NE 0 4-HYDROXY-BENZOIC- Pericarp -- ACID 0 4-METHYL-NONACOSANE Fruit 3.2 -- 0 5'-O- Plant -- DEMETHYLNARCOTINE 0 5-HYDROXY-3,7- Latex Exudate -- DIMETHOXYPHENANTHRE NE 0 6- Plant -- ACTEONLYDIHYDROSANG UINARINE 0 6-METHYL-CODEINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 6-METHYL-CODEINE Fruit -- 0 ACONITASE Latex Exudate -- 32 AESCULETIN Pericarp -- 3 ALANINE Seed 11780.0 12637.0 0.5273634907250652 -- Activities Count Chemical Plant Part Low PPM High PPM StdDev Refernce Citation 0 ALKALOIDS Latex Exudate 50000.0 250000.0 ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. 5 ALLOCRYPTOPINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 15 ALPHA-LINOLENIC-ACID Seed 1400.0 5564.0 -0.22115561650586155 -- 2 ALPHA-NARCOTINE Plant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. 17 APOMORPHINE Plant Father Nature's Farmacy: The aggregate of all these three-letter citations. 0 APOREINE Fruit -- 0 ARABINOSE Fruit ANON.