© Chagall ®, by SIAE 2016 th

WORLD SYMPOSIUM ON PULMONARY 6HYPERTENSION

Nice February 27-28 / March 1, 2018 INTRODUCTION

Traditionally the PH World Symposia series, started in Geneva in The objectives of the 6th WSPH are: 1973 and held every 5 years after the Evian edition in 1998 (Venice • Review of the major advances in pulmonary vascular science in 2003, Dana Point 2008, Nice 2013), has marked the progresses the past 5 years in pulmonary hypertension science and has anticipated future • Analyze the available evidence in different basic and clinical developments. The published supplement including the symposia areas by expert task forces proceedings constitutes a collection of articles among the most • Evaluation of the gaps of evidence in different areas and cited in this scientific area. proposals for future collaborative research programs • Elaboration of documents by the task forces, summarizing the Each new edition of the WSPH series has increased the attendance results of pre-symposium meetings (previous 18-24 months) compared with the previous one, testifying the growing interest • Discussion of the task forces documents at the symposium of the stakeholders of this area. More than 1200 international sessions with worldwide experts and with other stakeholders physicians attended the 5th WSPH – Nice 2013. • Final drafting of peer reviewed papers to be included in a supplement (prestigious medical journal) to facilitate the The structure of the 6th WSPH consists in 13 sessions where implementation of the 6th WSPH conclusions. WORLD world specialists in the field, divided in 13 Task Forces, present SYMPOSIUM the results of their studies developed in the last two years and Our purpose is to foster with the Symposium constructive scientific ON regarding some topic items: interactions and collaborations in the very unique scenario of the PULMONARY 1. Pathology & Pathobiology bay of Nice. HYPERTENSION 2. Genetics & Genomics 3. Pathophysiology of the RV and of the Pulmonary Circulation For the Steering Committee 4. PH Haemodynamic Definitions and Clinical Classifications and Nazzareno Galiè Characteristics of Specific PAH Subgroups Vallerie V. McLaughlin Nice February 27-28 / March 1, 2018 5. Diagnosis of Pulmonary Hypertension Lewis J. Rubin 6. Risk Stratification and Medical Therapy of Pulmonary Arterial Gérald Simonneau Hypertension 7. Right Ventricular Assistance and Lung Transplantation 8. Trials Design & New Therapies for Pulmonary Arterial Hypertension 9. PH due to Left Heart Diseases 10. PH due to Chronic Lung Diseases 11. CTEPH 12. Pediatric PH 13. Patients’ Perspectives

2 SCIENTIFIC PROGRAM ENDORSED BY The Symposium Steering Committee

• Adaani Frost, MD Houston, TX – USA • Nazzareno Galiè, MD Bologna, Italy • Ardeschir H. Ghofrani, MD Giessen, Germany • Marc Humbert, MD Paris, France • Anne Margaret Keogh, MD Sydney, Australia • Michael D. McGoon, MD Rochester, MN – USA • Vallerie V. McLaughlin, MD Ann Arbor, MI – USA • Nicholas W. Morrell, MD WORLD Cambridge, UK SYMPOSIUM • Lewis J. Rubin, MD ON San Diego, CA – USA PULMONARY • Werner Seeger, MD HYPERTENSION Giessen, Germany • Gérald Simonneau, MD Paris, France Nice • Rogerio Souza, MD February 27-28 / March 1, 2018 Sao Paulo, Brazil

The Symposium Secretariat

I&C s.r.l. Via Andrea Costa, 202/6 40134 Bologna (IT) Stefania Parolari and Giulia Delia Ph: +39 - 051.614.4004 Fax: +39 - 051.614.2772 @: [email protected] www.wsph2018.com

3 WORLD SYMPOSIUM ON PULMONARY HYPERTENSION

Nice February 27-28 / March 1, 2018

4 Index

• MAP OF THE CONGRESS CENTER . 6 • SYMPOSIUM TIMETABLE. 7 • SCIENTIFIC PROGRAM. 8

TUESDAY, FEBRUARY 27 • TASK FORCE 1 – Pathology & Pathobiology...... 8 • TASK FORCE 2 – Genetics and Genomics...... 8 • TASK FORCE 3 – Pathophysiology of the RV and of the Pulmonary Circulation ...... 9 • TASK FORCE 4 – PH Haemodynamic Definitions and Clinical Classifications and Characteristics of Specific PAH Subgroups...... 9 • TASK FORCE 5 – Diagnosis of Pulmonary Hypertension ...... 9

WEDNESDAY, FEBRUARY 28 • TASK FORCE 6 – Risk Stratification and Medical Therapy of Pulmonary Arterial Hypertension . 10 • TASK FORCE 7 – Right Ventricular Assistance and Lung Transplantation...... 10 • TASK FORCE 8 – Trials Design & New Therapies for Pulmonary Arterial Hypertension...... 10 WORLD • TASK FORCE 9 – PH due to Left Heart Diseases. 11 SYMPOSIUM ON THURSDAY, MARCH 1 PULMONARY • TASK FORCE 10 – PH due to Chronic Lung Diseases...... 11 HYPERTENSION • TASK FORCE 11 – CTEPH ...... 12 • TASK FORCE 12 - Pediatric PH...... 12 • TASK FORCE 13 – Patients’ Perspectives. 12 Nice February 27-28 / March 1, 2018 • POSTER SESSIONS...... 13 • BEST POSTER AWARDS...... 13 • POSTERS EXPOSED ON TUESDAY, FEBRUARY 27 . 15 • POSTERS EXPOSED ON WEDNESDAY, FEBRUARY 28...... 31 • POSTERS EXPOSED ON THURSDAY, MARCH 1...... 42

• GENERAL INFORMATION. 50 • INDEX OF POSTERS AUTHORS AND TASK FORCES MEMBERS. 53 • SPONSORS. 69

5 Map of the Acropolis

CONGRESS CENTER

Agora 1 Agora 2

POSTERS AND COFFEE BREAK AREA

REGISTRATION DESKS AND ASSOCIATION BOOTHS APOLLON < > MYKONOS BAR MEETING HALL AND RELAX AREA

WORLD < AGORA 2 AGORA 2 > POSTERS SYMPOSIUM AND COFFEE ON BREAK PULMONARY AREA SLIDE CLOAKROOM HYPERTENSION CENTER

Agora 3 Nice February 27-28 / March 1, 2018

MAIN ENTRANCE

LUNCH AREA

LUNCH AREA

6 Symposium timetable TF=Task Force

time Tuesday, February 27 time Wednesday, February 28 Thursday, March 1

08.30-09.00 Opening Ceremony Apollon Hall

09.00-10.30 09.00-10.30 TF 6. Risk Stratification and Medical TF 1. Pathology & Pathobiology Therapy of Pulmonary Arterial TF 10. PH due to Chronic Lung Diseases Apollon Hall Apollon Hall Hypertension

10.30-11.00 10.30-11.00 coffee break coffee break coffee break Agora 2 Agora 2 WORLD SYMPOSIUM 11.00-12.30 11.00-12.30 TF 7. Right Ventricular Assistance and ON TF 2. Genetics & Genomics TF 11. CTEPH Apollon Hall Apollon Hall Lung Transplantation PULMONARY HYPERTENSION 12.30-13.00 Best Poster Awards Ceremony Apollon Hall 12.30-14.00 Nice Lunch and posters Lunch and posters February 27-28 / March 1, 2018 Agora 2 and 3 13.00-14.00 Lunch and posters Agora 2 and 3

14.00-15.30 TF 3. Pathophysiology of the RV 14.00-15.30 TF 8. Trials Design & New Therapies TF 12. Pediatric PH Apollon Hall and of the Pulmonary Circulation Apollon Hall for Pulmonary Arterial Hypertension

15.30-16.00 15.30-16.00 coffee break coffee break coffee break Agora 2 Agora 2

TF 4. PH Haemodynamic Definitions 16.00-17.30 and Clinical Classifications 16.00-17.30 TF 9. PH due to Left Heart Diseases TF 13. Patients' Perspectives Apollon Hall and Characteristics of Specific PAH Apollon Hall Subgroups

17.30-19.00 TF 5. Diagnosis of Pulmonary 17.30-18.00 Final remarks and next steps Apollon Hall Hypertension Apollon Hall 7 Scientific Program TUESDAY, FEBRUARY 27 APOLLON HALL APOLLON HALL 11.00-12.30 08.30 - 09.00 Task Force 2. Genetics & Genomics Opening Ceremony CHAIR: NICHOLAS W. MORRELL, Cambridge UK Nazzareno Galiè, Bologna ITALY CHAIR: JAMES E. LOYD, Nashville TN USA Vallerie V. McLaughlin, Ann Arbor MI USA MICHEALA A. ALDRED, Indianapolis IN USA Lewis J. Rubin, La Jolla CA USA WENDY K. CHUNG, New York NY USA Gérald Simonneau, Paris FRANCE GREGORY ELLIOTT, Salt Lake City UT USA WILLIAM NICHOLS, Cincinnati OH USA , Paris FRANCE 09.00-10.30 FLORENT SOUBRIER RICHARD C. TREMBATH, London UK Task Force 1. Pathology & Pathobiology CHAIR: MARC HUMBERT, Paris FRANCE CHAIR: MARLENE RABINOVITCH, Stanford CA USA Objectives: SEBASTIEN BONNET, Chemin Sainte-Foy CANADA - State of the Art WORLD PETER DORFMÜLLER, Paris FRANCE - Pathobiology links between mutations and disease SYMPOSIUM CHRISTOPHE GUIGNABERT, Le Plessis Robinson FRANCE (why low penetrance) ON JAMES R. KLINGER, Rhode Island RI USA - Genetic counselling and healthy mutation carriers PULMONARY MARK R. NICOLLS, Stanford CA USA - Practical application of genomics ANDREA J. OLSCHEWSKI, Graz AUSTRIA - Proposed Future Directions (specific and detailed) HYPERTENSION SONI SAVAI PULLAMSETTI, Bad Nauheim GERMANY RALPH T. SCHERMULY, Giessen GERMANY KURT R. STENMARK, Aurora CO USA 12.30-13.00 Best Poster Awards Ceremony Nice February 27-28 / March 1, 2018 Objectives: - State of the art AGORA 2 and 3 - Main bench to bedside achievements 13.00-14.00 - Recommendation on how to identify most relevant pathways Lunch and posters - Most appropriate cells, tissues and animal models - Proposed Future Directions (specific and detailed)

AGORA 2 10.30-11.00 coffee break

8 Scientific Program TUESDAY, FEBRUARY 27 APOLLON HALL APOLLON HALL 14.00-15.30 16.00-17.30 Task Force 3. Pathophysiology of the RV and of the pulmonary Task Force 4. PH haemodynamic definitions and clinical circulation classifications and characteristics of specific PAH subgroups CHAIR: ROBERT NAEIJE, Brussels BELGIUM CHAIR: GÉRALD SIMONNEAU, Paris FRANCE CHAIR: ANTON VONK NOORDEGRAAF, Amsterdam THE NETHERLANDS CHAIR: ROGERIO SOUZA, Sao Paulo BRAZIL KELLY MARIE CHIN, Dallas TX USA DAVID S. CELERMAJER, Sydney AUSTRALIA FRANÇOIS HADDAD, Palo Alto CA USA CHRISTOPHER P. DENTON, London UK PAUL M. HASSOUN, Baltimore MD USA MICHAEL A. GATZOULIS, London UK ANNA R. HEMNES, Nashville TN USA MICHAEL KROWKA, Rochester MN USA SUSAN R. HOPKINS, San Diego CA USA DAVID MONTANI, Paris FRANCE STEVEN M. KAWUT, Philadelphia PA USA PAUL WILLIAMS, Johannesburg SOUTH AFRICA DAVID LANGLEBEN, Montreal CANADA JOOST LUMENS, Maastricht THE NETHERLANDS Objectives: - State of the art WORLD Objectives: - Haemodynamic definitions SYMPOSIUM - State of the Art - Atypical PAH ON - Main bench to bedside achievements - PVOD PULMONARY - MRI, echocardiography and metabolic studies - Early detection and irreversibility thresholds of RV dysfunction HYPERTENSION 17.30 – 19.00 - Proposed future directions (specific and detailed) Task Force 5. Diagnosis of pulmonary hypertension CHAIR: ADAANI FROST, Houston TX USA AGORA 2 CHAIR: ADAM TORBICKI, Otwock POLAND Nice February 27-28 / March 1, 2018 15.30-16.00 DAVID B. BADESCH, Aurora CO USA coffee break SIMON GIBBS, London UK DEEPA GOPALAN, London UK DINESH KHANNA, Ann Arbor MI USA ALESSANDRA MANES, Bologna ITALY RONALD J. OUDIZ, Torrance Los Angeles CA USA TORU SATOH, Tokyo JAPAN FERNANDO TORRES, Dallas TX USA

Objectives: - State of the art - Practice recommendations - New diagnostic tools? - Proposed future directions (specific and detailed)

9 Scientific Program WEDNESDAY, FEBRUARY 28 APOLLON HALL AGORA 2 and 3 09.00-10.30 12.30-14.00 Task Force 6. Risk stratification and medical therapy of pulmonary Lunch and posters arterial hypertension CHAIR: NAZZARENO GALIÈ, Bologna ITALY APOLLON HALL CHAIR: VALLERIE V. MCLAUGHLIN, Ann Arbor MI USA 14.00-15.30 , Boston MA USA RICHARD N. CHANNICK Task Force 8. Trials design and new therapies for pulmonary ROBERT P. FRANTZ, Rochester MN USA EKKEHARD GRÜNIG, Heidelberg GERMANY arterial hypertension CHAIR: LEWIS J. RUBIN, La Jolla CA USA ZHI CHENG JING, Beijing CHINA CHAIR: OLIVIER SITBON, Paris FRANCE IOANA R. PRESTON, Boston MA USA AMANY N. EL-GAZAYERLY, The Hague THE NETHERLANDS TOMAS PULIDO, Mexico City MEXICO MARDI I. GOMBERG MAITLAND, Falls Church VA USA ZEENAT SAFDAR, Houston TX USA JOHN GRANTON, Toronto CANADA YUICHI TAMURA,Tokyo JAPAN WORLD MICHAEL I. LEWIS, Los Angeles CA USA STEPHEN C. MATHAI, Baltimore MD USA SYMPOSIUM Objectives: MAURIZIO RAINISIO, Imperia ITALY ON - State of the art NORMAN STOCKBRIDGE, Silver Spring MD USA PULMONARY - Practice recommendations MARTIN R. WILKINS, London UK - General measures and non-specific therapy (pregnancy, a/c ROHAM ZAMANIAN, Stanford CA USA HYPERTENSION therapy, rehabilitation) - Proposed future directions (specific and detailed) Objectives: - State of the art Nice AGORA 2 - Current challenges February 27-28 / March 1, 2018 10.30-11.00 - Proposed future directions (specific and detailed) coffee break AGORA 2 APOLLON HALL 15.30-16.00 11.00-12.30 coffee break Task Force 7. Right ventricular assistance and lung transplantation CHAIR: WALTER KLEPETKO, Vienna AUSTRIA CHAIR: MARIUS HOEPER, Hanover GERMANY RAYMOND L. BENZA, Pittsburgh PA USA PAUL A. CORRIS, Newcastle Upon Tyne UK MARC DE PERROT, Toronto CANADA ELIE FADEL, Paris FRANCE ANNE M. KEOGH, Sydney AUSTRALIA CHRISTIAN KÜHN, Hanover GERMANY LAURENT SAVALE, Paris FRANCE

Objectives: - State of the art - ICU management of severe PH - Practice recommendations 10 - Proposed future directions (specific and detailed) Scientific Program WEDNESDAY, FEBRUARY 28 THURSDAY, MARCH 1 APOLLON HALL APOLLON HALL 16.00-17.30 09.00-10.30 Task Force 9. PH due to left heart diseases Task Force 10. PH due to chronic lung diseases CHAIR: JEAN LUC VACHIERY, Brussels BELGIUM CHAIR: WERNER SEEGER, Giessen GERMANY CHAIR: TERESA DE MARCO, San Francisco CA USA CHAIR: STEVEN D. NATHAN, Falls Church VA USA IRINA CHAZOVA, Moscow RUSSIAN FEDERATION JOAN ALBERT BARBERÀ, Barcelona SPAIN JOHN G. COGHLAN, London UK SEAN P. GAINE, Dublin IRELAND MARCO GUAZZI, Milan ITALY SERGIO HARARI, Milan ITALY IRENE LANG, Vienna AUSTRIA FERNANDO J. MARTINEZ, Ann Arbor MI USA MASSIMILIANO PALAZZINI, Bologna ITALY HORST OLSCHEWSKI, Graz AUSTRIA STEPHAN H. ROSENKRANZ, Cologne GERMANY KAREN M. OLSSON, Hanover GERMANY RYAN J. TEDFORD, Charleston SC USA ANDREW J. PEACOCK, Glasgow UK JOANNA PEPKE-ZABA, Cambridge UK Objectives: STEEVE PROVENCHER, Chemin Sainte-Foy CANADA - State of the art NORBERT WEISSMANN, Giessen GERMANY WORLD - Current challenges SYMPOSIUM - Vasoreactivity testing in left heart disease Objectives: ON - Proposed future directions (specific and detailed) - State of the art - Current challenges PULMONARY - Proposed future directions (specific and detailed) HYPERTENSION

AGORA 2 10.30-11.00 Nice coffee break February 27-28 / March 1, 2018

11 Scientific Program THURSDAY, MARCH 1 APOLLON HALL AGORA 2 11.00-12.30 15.30-16.00 Task Force 11. CTEPH coffee break CHAIR: ARDESCHIR H. GHOFRANI, Giessen GERMANY CHAIR: NICK H. KIM, La Jolla CA USA APOLLON HALL CHAIR: , Cambridge UK DAVID P. JENKINS 16.00-17.30 MARION DELCROIX, Leuven BELGIUM XAVIER JAIS, Paris FRANCE Task Force 13. Patients’ perspectives CHAIR: MICHAEL D. MCGOON, Rochester MN USA MICHAEL M. MADANI, San Diego CA USA CHAIR: PISANA FERRARI, Milan ITALY HIROMI MATSUBARA, Okayama JAPAN IAIN ARMSTRONG, Sheffield UK ECKHARD MAYER, Bad Nauheim GERMANY MIGDALIA DENIS, Miami FL USA TAKESHI OGO, Osaka JAPAN LUKE S. HOWARD, London UK VICTOR F. TAPSON, Los Angeles CA USA SANJAY MEHTA, London CANADA NORIKO MURAKAMI, Yamatoshi JAPAN WORLD Objectives: BRAD A. WONG, Silver Spring MD USA SYMPOSIUM - State of the art ON - Current challenges Objectives: PULMONARY - Treatment selection - Mission HYPERTENSION - Proposed future directions (specific and detailed) - Narrative medicine (disease, illness, sickness) - Current challenges AGORA 2 and 3 - Proposed future directions (specific and detailed) 12.30-14.00 Nice Lunch and posters February 27-28 / March 1, 2018 17.30-18.00 Final remarks and next steps APOLLON HALL Nazzareno Galiè, Vallerie V. McLaughlin, Gérald Simonneau, Lewis J. Rubin 14.00-15.30 Task Force 12. Pediatric PH CHAIR: ERIKA BERMAN ROSENZWEIG, New York NY USA CHAIR: ROLF M.F. BERGER, Groningen THE NETHERLANDS STEVEN ABMAN, Aurora CO USA IAN T. K. ADATIA, Edmonton CANADA MAURICE BEGHETTI, Geneve SWITZERLAND DAMIEN BONNET, Paris FRANCE CHRISTINE GARNETT, Silver Spring MD USA SHEILA G. HAWORTH BUSK, LondonUK DUNBAR IVY, Aurora CO USA

Objectives: - State of the art - Current challenges - Proposed future directions (specific and detailed)

12 POSTER SESSIONS

BEST POSTER AWARDS These posters are exposed for the whole period of the World Symposium: February 27, 28 and March 1

BASIC SCIENCE

1 IMMUNE REPERTOIRE-BASED SIGNATURES IN THE BLOOD AND 3 GENETIC ANALYSIS OF 2,156 WHO GROUP 1 PAH PATIENTS IN THE LUNG VESSEL-ASSOCIATED TERTIARY LYMPHOID TISSUE ENROLLED IN THE PAH BIOBANK IN PRE-CAPILLARY PULMONARY HYPERTENSION Michael Pauciulo*, Katie Lutz, Anna Walsworth, Lisa Martin, William Nichols Sylvia Cohen-Kaminsky*[2], Sébastien J Dumas[2], Isabelle Klingel-Schmitt[3], Cincinnati Children’s Hospital Medical Center ~ Cincinnati ~ United States of America Matthieu Vocelle[3], Anais Courtier[4], Orchidee Filipe-Santo[4], Gilles Parmentier[4], Solène Perez[4], Caroline Suberbielle[5], Sophie Caillat- Zucman[6], Gerald Simonneau[2], Frederic Perros[3], Marc Humbert[2], Morad Nakhleh[3], David Montani[2], Barbara Girerd[2], Andrei Seferian[2], Peter Dorfmüller[1] WORLD [1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de SYMPOSIUM Médecine, Université Paris-Saclay ~ Le Plessis Robinson 92350 ~ France, [2]INSERM ON UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Plessis-Robinson F-92350, AP-HP Assistance Publique-Hôp de PULMONARY Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre F-94270, France ~, [3] INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Médecine, HYPERTENSION Université Paris-Saclay, Le Plessis Robinson, F-92350 ~ France, [4]Former (Research and Development, ImmunID Technologies), Grenoble F-38054 ~ France, [5]Regional Histocompatibility Laboratory IR7, APHP, Hopital Saint Louis, Paris, F-75010 ~ France, [6] Unit of Immunology and Genetics of Type 1 Diabetes., INSERM U986, Hôpital St-Vincent de Paul; Université Paris Descartes, Faculté de Médecine, Paris F-75014 ~ France Nice February 27-28 / March 1, 2018 2 A GENOME-WIDE ASSOCIATION STUDY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION Michael Newnham*[1], Mark Toshner[1], Marta Bleda[1], William Auger[2], Joan Albert Barberà[3], Harm Jan Bogaard[4], John Cannon[5], Gerry Coghlan[6], Paul Corris[7], Marion Delcroix[8], John Dunning[5], Heather Elding[9], Simon Gibbs[10], Charaka Hadinnapola[1], David Jenkins[5], David Kiely[11], Irene Lang[12], Eckhard Mayer[13], Choo Ng[5], Andrew Peacock[14], Nicholas Screaton[5], Karen Sheares[5], Michael Simpson[15], Nicole Soranzo[9], Dolores Taboada[5], Richard Trembath[15], Steven Tsui[5], Martin Wilkins[16], Stephen John Wort[17], Stefan Gräf[1], Joanna Pepke-Zaba[5], Nicholas Morrell[1] [1]University of Cambridge ~ Cambridge ~ United Kingdom, [2]UC San Diego ~ San Diego ~ United States of America, [3]University of Barcelona ~ Barcelona ~ Spain, [4] VU Medical Centre ~ Amsterdam ~ Netherlands, [5]Papworth Hospital ~ Cambridge ~ United Kingdom, [6]Royal Free Hospital ~ London ~ United Kingdom, [7]Newcastle University ~ Newcastle ~ United Kingdom, [8]KU Leuven - University of Leuven ~ Leuven ~ Belgium, [9]Wellcome Trust Sanger Institute ~ Cambridgeshire ~ United Kingdom, [10]Hammersmith Hospital ~ London ~ United Kingdom, [11]Royal Hallamshire Hospital ~ Sheffield ~ United Kingdom, [12]Medical University of Vienna ~ Vienna ~ Austria, [13]Kerckhoff Heart and Lung Center ~ Bad Nauheim ~ Germany, [14]Golden Jubilee Hospital ~ Glasgow ~ United Kingdom, [15]Kings College ~ London ~ United Kingdom, [16]Imperial College ~ London ~ United Kingdom, [17]Royal Brompton Hospital ~ London ~ United Kingdom

13 POSTER SESSIONS

BEST POSTER AWARDS These posters are exposed for the whole period of the World Symposium: February 27, 28 and March 1

CLINICAL SCIENCE

4 REDUCED RIGHT VENTRICULAR CONTRACTILE RESERVE IN 8 SEQUENTIAL HYBRID THERAPY WITH PULMONARY PATIENTS WITH SYSTEMIC SCLEROSIS AND BORDERLINE ENDARTERECTOMY AND ADDITIONAL BALLOON PULMONARY PULMONARY ARTERIAL PRESSURES ANGIOPLASTY FOR CHRONIC THROMBOEMBOLIC Alberto Maria Marra*[1], Christian Nagel[1], Benjamin Egenlauf[1], Satenik PULMONARY HYPERTENSION. Harutyunova[1], Norbert Blank[2], Hanns-Martin Lorenz[2], Christoph Fiehn[3], Kenichi Yanaka*[1], Kazuhiko Nakayama[1], Toshiro Shinke[1], Hiromasa Nicola Benjamin[1], Christine Fischer[4], Antonio Cittadini[5], Eduardo Otake[1], Hiroyuki Kawamori[1], Yuto Shinkura[1], Naoki Tamada[1], Hiroyuki Bossone[6], Ekkehard Grünig[1] Onishi[1], Yasunori Tsuboi[1], Seimi Kobayashi[1], Hiroshi Tanaka[2], Yutaka WORLD [1]Centre for Pulmonary Hypertension at Thoraxclinic, University Hospital Heidelberg, Okita[2], Noriaki Emoto[1], Ken-Ichi Hirata[1] [2] Heidelberg, Germany ~ Heidelberg ~ Germany, Department of Rheumatology, [1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University [3] SYMPOSIUM University Hospital Heidelberg, Heidelberg, Germany ~ Heidelberg ~ Germany, Graduate School of Medicine ~ Kobe ~ Japan, [2]Division of Cardiovascular Surgery, [4] ON Praxis für Rheumatologie und klinische Immunologie ~ Baden-Baden ~ Germany, Department of Surgery, Kobe University Graduate School of Medicine ~ Kobe ~ Japan Department of Human Genetics; University of Heidelberg; ~ Heidelberg ~ Germany, [5]Department of Translational Medical Sciences ~ Naples ~ Italy, [6]Department, 9 EARLY DETECTION OF PULMONARY ARTERIAL HYPERTENSION PULMONARY Cardiology Division, “Cava de’ Tirreni and Amalfi Coast” Hospital, University of Salerno, Salerno, Italy ~ Salerno ~ Israel IN APPARENTLY HEALTHY CHILDREN BY MANDATORY HYPERTENSION ELECTROCARDIOGRAPHY SCREENING: A JAPANESE 5 RISK ASSESSMENT IN SCLERODERMA PATIENTS WITH NEWLY NATIONWIDE SURVEY DIAGNOSED PULMONARY ARTERIAL HYPERTENSION: Mitani Yoshihide*[1], Sawada Hirofumi[1], Nakayama Tomotaka[2], Fukushima APPLICATION OF THE ESC/ERS RISK PREDICTION MODEL Hiroyuki[3], Kogaki Shigetoyo[4], Igarashi Takehiro[5], Ichida Fukiko[6], Ono [7] [8] [9] [10] Nice Valentina Mercurio*, Nermin Diab, Grace Peloquin, Rachel Damico, Todd Yasuo , Nakanishi Toshio , Doi Shozaburo , Ishikawa Shiro , Matsushima February 27-28 / March 1, 2018 [11] [5] [2] Kolb, Stephen Mathai, Paul Hassoun Masaki , Yamada Osamu , Saji Tsutomu [1] [2] Johns Hopkins University ~ Baltimore ~ United States of America Mie University Graduate School of Medicine ~ Tsu ~ Japan, Toho University Omori Medical Center ~ Tokyo ~ Japan, [3]Keio University School of Medicine ~ Tokyo ~ Japan, 6 IDENTIFICATION OF GENETIC DEFECTS IN PULMONARY [4]Osaka University School of Medicine ~ Osaka ~ Japan, [5]National Cerebral and Cardiovascular Center ~ Osaka ~ Japan, [6]Toyama University School of Medicine ~ ARTERIAL HYPERTENSION BY A NEW GENE PANEL DIAGNOSTIC Toyama ~ Japan, [7]Shizuoka Children’s Hospital ~ Shizuoka ~ Japan, [8]Tokyo Women’s TOOL Medical University ~ Tokyo ~ Japan, [9]Tokyo Medical and Dental University ~ Tokyo ~ Jie Song*[1], Christina Alessandra Eichstaedt[1], Rebecca Rodriguez Viales[2], Japan, [10]Fukuoka Children’s Hospital ~ Fukuoka ~ Japan, [11]Social Insurance Chukyo Nicola Benjamin[1], Satenik Harutyunova[1], Christine Fischer[3], Katrin Hospital ~ Nagoya ~ Japan Hinderhofer[3], Ekkehard Grünig[1] [1]Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2] European Molecular Biology Laboratory ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Germany 7 EFFECTIVENESS OF PERCUTANEOUS TRANSLUMINAL PULMONARY ANGIOPLASTY FOR LONG-TERM OUTCOMES IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION Kaori Takeuchi*[2], Takumi Inami[2], Masaharu Kataoka[1], Hanako Kikuchi[2], Shigeta Yohei[2], Ayumi Goda[2], Haruhisa Ishiguro[2], Hideaki Yoshino[2], Toru Satoh[2] [1]Keio University School of Medicine ~ Tokyo ~ Japan, [2]Kyorin University School of Medicine ~ Tokyo ~ Japan

14 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOLOGY AND PATHOBIOLOGY

A10 PAH-MIMICKING CHIP TO ELUCIDATE THE DISEASE A14 FORMINS MAY REGULATE ENDOTHELIAL TO MESCHYMAL PATHOGENESIS AND SCREEN ANTI-PAH DRUGS TRANSITION VIA VASCULAR ENDOTHELIAL CADHERIN Fakhrul Ahsan*, Taslim A Al Hilal, Ali Keshavarz Meghan Bernier*, Anil Bhatta, Lewis Romer Texas Tech University Health Sciences Center ~ Amarillo ~ United States of America Johns Hopkins School of Medicine ~ Baltimore ~ United States of America A11 URIC ACID CAUSES EXCESSIVE PULMONARY ARTERIAL A15 NEUTRALIZATION OF CXCL12 REVERSES PULMONARY SMOOTH MUSCLE CELL PROLIFERATION VIA URATV1 VASCULAR REMODELING BY DECREASING PULMONARY UPREGULATION IN PULMONARY ARTERIAL HYPERTENSION ARTERIAL SMOOTH MUSCLE CELL ACCUMULATION Satoshi Akagi*, Tamura Yuichi, Tu Ly, Phan Carole, Thuillet Raphaël, Sekine Jennifer Bordenave*[1], Raphaël Thuillet[1], Ly Tu[1], Carole Phan[1], Gérald Ayumi, Huertas Alice, Humbert Marc, Guignabert Christophe Simonneau[1], Alice Huertas[1], Marcel Hibert[2], Dominique Bonnet[2], Marc [1] [2] [1] INSERM UMR_S 999 / University of Paris-Sud / Université Paris-Saclay ~ Le Kremlin- Humbert , Nelly Frossard , Christophe Guignabert WORLD Bicêtre ~ France [1]INSERM UMR_S999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin- SYMPOSIUM Bicêtre ~ France, [2]UMR 7200 CNRS-Université de Strasbourg / LabEx MEDALIS, Faculté A12 HEPARAN SULFATE IMBALANCE AND FINE STRUCTURAL de Pharmacie ~ Illkirch ~ France ON MODIFICATIONS OF THEIR SULFATION PATTERNS IN LUNG ARE PULMONARY ASSOCIATED WITH FUNCTIONAL EFFECTS IN PRECAPILLARY A16 COMPREHENSIVE CHARACTERIZATION OF MESENCHYMAL PULMONARY HYPERTENSION STEM CELLS IN PAH HYPERTENSION [4] [4] [4] [1] [2] [3] [3] Kyunghee Byun* , Hanul Choi , Seyeon Oh , Duk-Kyung Kim , Duk-Kyung Patricia Albanese* , Sébastien Dumas , Benoit Ranchoux , Sara [2] [2] [4] [3] [4] [2] [2] [2] [1] Kim , Byeong-Ju Lee , Jeongwon Ryu , Hae Ok Jung , Kevin Chung , Shamdani , Sandrine Chantepie , Emilie Henault , David Montani , [4] Barbara Girerd[1], Peter Dormuller[3], Elie Fadel[3], Philippe Dartevelle[3], Hanul Choi Frederic Perros[3], Marc Humbert[1], Dulce Papy-Garcia[2], Sylvia Cohen- [1]Department of Cardiology, Sejong General Hspital ~ Bucheon ~ Korea, Republic of, Nice [1] [2]Department of Cardiovascular Medicine, Gachon University Gil Medical Center ~ February 27-28 / March 1, 2018 Kaminsky [3] [1] Incheon ~ Korea, Republic of, Division of Cardiology, Department of Internal Medicine, INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of, Médecine, Université Paris-Saclay. AP-HP Assistance Publique-Hôpitaux de Paris, Service [4] [2] Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute ~ de Pneumologie, Hôpital Bicêtre ~ 94270, Le Kremlin-Bicêtre ~ France, Laboratoire Incheon ~ Korea, Republic of CRRET/ EAC CNRS 7149, ERL CNRS 9215, Université Paris Est Créteil ~ 94010 Créteil ~ [3] France, INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, Faculté de A17 INDOLEAMINE-2,3-DIOXYGENASE AS A POTENTIAL Médecine, Université Paris-Saclay ~ 92350, Le Plessis-Robinson, ~ France THERAPEUTIC TARGET OF PULMONARY HYPERTENSION A13 EXPERIMENTAL AND HUMAN PULMONARY VENO-OCCLUSIVE Zongye Cai*, Richard Wb Van Duin, Dirk Jan Duncker, Daphne Merkus DISEASE: SIMILARITIES AND DIFFERENCES Erasmus MC ~ Rotterdam ~ Netherlands Fabrice Antigny*[1], Esther Nossent[2], Melanie Lambert[1], Benoit Ranchoux[1], Audrey Courboulin[1], Barbara Girerd[3], Florent Soubrier[4], Florence Lecerf[1], A18 APELIN-13 CO-TREATMENT WITH UMBILICAL CORD BLOOD- Aurélie Hautefort[1], Harm Jan Bogaard[2], Elie Fadel[1], Gerald Simonneau[3], DERIVED MESENCHYMAL STEM CELLS IMPROVES ENGRAFTED Anton Vonk Noordegraaf[2], Katrien Grünberg[2], Marc Humbert[1], David CELL SURVIVAL AND INHIBITS MACROPHAGE ACTIVATION IN Montani[3], Peter Dorfmuller[1], Frederic Perros[1] PULMONARY ARTERIAL HYPERTENSION MURINE MODEL [1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Seungbum Choi*[1], Byeong-Ju Lee[2], Seyeon Oh[1], Kuk Hui Son[1], Duk- Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]Dept of Pulmonary Kyung Kim[2], Hanul Choi[2], Jeongwon Ryu[3], Hae Ok Jung[4], Kyunghee diseases and Dept of Pathology, VU University Medical Center ~ Amsterdam ~ Byun[1], Kevin Chung[1] Netherlands, [3]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté [1]Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôp de Paris, Service [2] [4] ~ Incheon ~ Korea, Republic of, Department of Cardiovascular Medicine, Gachon de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, INSERM UMR_S 956, [3] Université Pierre and Marie Curie Université ~ Paris ~ France University Gil Medical Center ~ Incheon ~ Korea, Republic of, Advenced Medical Technology Laboratory Healcerion Co., Ltd ~ Seoul ~ Korea, Republic of, [4]Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of 15 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOLOGY AND PATHOBIOLOGY

A19 NMDA-TYPE GLUTAMATE RECEPTOR ACTIVATION PROMOTES A23 HISTONE DEACETYLASE 7 MEDIATES HYPOXIA-INDUCED VASCULAR REMODELING AND PULMONARY ARTERIAL MITOCHONDRIAL REPROGRAMING IN PULMONARY HYPERTENSION HYPERTENSION AND CANCER Sylvia Cohen-Kaminsky*[1], Sébastien J Dumas[2], Gilles Bru-Mercier[2], Audrey Elisabetta Gamen*[1], Prakash Chelladurai[1], Werner Seeger[2], Soni Savai Courboulin[2], Marceau Quatredeniers[2], Catherine Rucker-Martin[2], Fabrice Pullamsetti[1] [2] [2] [2] [2] Antigny , Morad K Nakhleh , Benoit Ranchoux , Elodie Gouadon , Maria [1](1) Max-Planck Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, [2] Candida Vinhas[2], Matthieu Vocelle[2], Nicolas Raymond[2], Peter Dorfmüller[2], Universities of Giessen and Marburg Lung Center (UGMLC) ~ Giessen ~ Germany Elie Fadel[2], Frédéric Perros[2], Marc Humbert[1], [1]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de A24 COMPLEMENTARY AND INTEGRATED VALUE OF SIX-MINUTE Médecine, Université Paris-Saclay, Le Plessis-Robinson F-92350, AP-HP Assistance WALK TEST, VE/VCO2 SLOPE AND RIGHT ATRIAL STRAIN WORLD Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre IN EARLY DETECTION OF FUNCTIONAL IMPAIRMENT AND [2] F-94270, France ~, INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris-Sud, VASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS SYMPOSIUM Faculté de Médecine, Université Paris-Saclay, Le Plessis Robinson, F-92350 ~ France ON Miriam Gravellone*, Ailia Giubertoni, Jacopo Zanaboni, Cristina Piccinino, A20 RASSF1A REGULATES HIF-1: TRIGGERING A FEED FORWARD Paolo Nicola Marino PULMONARY LOOP IN HYPOXIA DRIVEN PULMONARY HYPERTENSION Clinical Cardiology, “Maggiore della Carità” Hospital ~ Novara ~ Italy Swati Dabral*[1], Christian Muecke[1], Rajkumar Savai[1], Chanil Valsarajan[1], HYPERTENSION Astrid Wietelmann[1], Gregg Semenza[3], Christos Samakovalis[2], Norbert A25 BIOMARKER DISCOVERY IN PULMONARY ARTERIAL Weissmann[2], Friedrich Grimminger[2], Werner Seeger[2], Reinhard HYPERTENSION: EXERCISE TRAINING, OR NIGHTLY OXYGEN Dammann[2], Soni Savai Pullamsetti[1] Gabriele Grunig*[1], Christina Eichstaedt[3], Nedim Durmus[1], Stéphanie [4] [4] [4] [3] [2] [1]Max-Planck Insitute for heart and lung research ~ Bad Nauheim ~ Germany, [2] Saxer , Konrad E Bloch , Sylvia Ulrich , Ekkehard Grünig , Serhiy Pylawka Nice University of giessen ~ Giessen ~ Germany, [3]Johns Hopkins University School of [1]NYU School of Medicine ~ New York ~ United States of America, [2]Mirna Analytics LLC February 27-28 / March 1, 2018 Medicine ~ Baltimore ~ United States of America ~ New York ~ United States of America, [3]Thoraxclinic at the University Clinic Heidelberg ~ Heidelberg ~ Germany, [4]University of Zurich ~ Zurich ~ Switzerland A21 INFLUENCE OF 16ALPHA-OHE2 ON MIGRATION AND ARYL HYDROCARBON RECEPTOR SIGNALLING IN BLOOD A26 CHARACTERIZATION OF RATS MUTATED IN BMPR2: THE MAIN OUTGROWTH ENDOTHELIAL CELLS IN PAH. GENETIC RISK FACTOR FOR PAH [1] [1] [2] Nina Denver*[1], Craig Docherty[1], Katie Yates Harvey[1], Ruth Andrew[2], Aurélie Hautefort* , Catherine Rucker-Martin , Boris Manoury , Melanie [1] [1] [1] [1] Natalie Homer[2], Nicholas Morrell[3], Margaret Maclean[1] Lambert , Angele Boet , Florence Lecerf , Peter Dorfmüller , Séverine [3] [3] [3] [4] [1] [2] Ménoret , Laurent Tesson , Igniacio Anegon , David Montani , Barbara University of Glasgow ~ Glasgow ~ United Kingdom, University of Edinburgh ~ [4] [4] [1] [1] Edinburgh ~ United Kingdom, [3]University of Cambridge ~ Cambridge ~ United Girerd , Marc Humbert , Fabrice Antigny , Frederic Perros Kingdom [1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]Inserm, UMR S1180, A22 A MEASUREMENT OF THE COMMON CAROTID ARTERY IN Faculté de Pharmacie, Université Paris Sud ~ Châtenay-Malabry ~ France, [3]INSERM PATIENTS WITH PULMONARY HYPERTENSION UMR 1064-ITUN; CHU de Nantes ~ Nantes ~ France, [4]INSERM UMR-S 999, Hôpital [2] [2] [2] [1] Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- Gunnar Einarsson* , Dan Henrohn , Frida Ulander , Tord Naessén , Marita HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le [1] [2] Larsson , Gerhard Wikström Kremlin-Bicêtre ~ France [1]Department of Women’s and Children’s Health, Obstetrics and Gynaecology, Uppsala University Hospital, Uppsala ~ Uppsala ~ Sweden, [2]Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden ~ Uppsala ~ Sweden

16 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOLOGY AND PATHOBIOLOGY

A27 PROPOSAL OF CLINICAL DIAGNOSTIC CRITERIA FOR A31 COMPARATIVE PHYSIOLOGICAL EVALUATION OF THE STATUS PULMONARY VENO-OCCLUSIVE DISEASE (PVOD) BASED ON OF PULMONARY HEALTH IN YOUNG SMOKERS AND NON- THE PVOD REGISTRY STUDY IN JAPAN SMOKERS Hatsue Ishibashi-Ueda*[1], Keiko Ohta-Ogo[1], Seiichiro Sakao[2], Nobuhiro Natalia Mokina*, Vasily Pyatin, Egor Mokin [3] [4] [6] [5] Tanabe , Teruaki Oka , Masanori Kitaichi , Norifumi Nakanishi , Toru Samara State Medical University ~ Samara ~ Russian Federation Satoh[7], Hiromi Matsubara[8], Koichiro Tatsumi[2] [1]Department of Pathology, National Cerebral and Cardiovascular Center, ~ Suita, A32 SCREENING OF AUTOANTIBODIES IN PATIENT WITH CHIRONIC Osaka ~ Japan, [2]Department of Respirology, Graduate School of Medicine, Chiba THROMBOEMBOLIC PULMONARY HYPERTENSION AND ITS University ~ Chiba ~ Japan, [3]Department of Advanced Medicine in Pulmonary [4] VALIDATION IN PATIENT WITH PULMONARY HYPERTENSION Hypertension, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan, [1] [2] [3] [2] Department of Pathology,Kanto Central Hospital ~ Tokyo ~ Japan, [5]Department of Akira Naito* , Tanabe Nobuhiro , Hiwasa Takaki , Jujo Takayuki , Sugiura [1] [1] [1] Cardiovascular Medicine, Minami-Osaka Hospital ~ Osaka ~ Japan, [6]Department Toshihiko , Sakao Seiichiro , Tatsumi Koichiro WORLD of Pathology, National Hospital Organization Minami Wakayama Medical Center ~ [1]Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba SYMPOSIUM Tanabe, Wakayama ~ Japan, [7]Department of Cardiology, Kyorin University School of ~ Japan, [2]Department of Advanced Medicine in Pulmonary Hypertension, Graduate [8] ON Medicine ~ Mitaka, Tokyo ~ Japan, Department of Clinical Science, National Hospital School of Medicine, Chiba University ~ Chiba ~ Japan, [3]Department of Biochemistry Organization Okayama Medical Center ~ Okayama ~ Japan and Genetics, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan PULMONARY A28 SELENOPROTEIN P PROMOTES THE DEVELOPMENT OF A33 PULMONARY VASCULAR REMODELING PATTERNS AND HYPERTENSION PULMONARY ARTERIAL HYPERTENSION -A POSSIBLE NOVEL EXPRESSION OF GCN2 IN PULMONARY VENO-OCCLUSIVE THERAPEUTIC TARGET- DISEASE Nobuhiro Kikuchi*[1], Kimio Satoh[1], Ryo Kurosawa[1], Nobuhiro Yaoita[1], Esther Nossent*[1], Antigny Fabrice[2], David Montani[3], Harm Jan Bogaard[1], Mohammad Elias-Al-Mamun[1], Mohammad Abdul Hai Siddique[1], Junichi Maria-Rosa Ghigna[4], Mélanie Lambert[2], Vincent Thomas De Montpréville[4], [1] [1] [1] [1] Nice Omura , Taijyu Satoh , Masamichi Nogi , Shinichiro Sunamura , Satoshi Barbara Girerd[3], Xavier Jaïs[3], Laurent Savale[3], Olaf Mercier[5], Elie Fadel[5], February 27-28 / March 1, 2018 Miyata[1], Yoshiro Saito[2], Yasushi Hoshikawa[3], Yoshinori Okada[4], Hiroaki Florent Soubrier[6], Olivier Sitbon[3], Gérald Simonneau[3], Anton Vonk Shimokawa[1] Noordegraaf[1], Marc Humbert[3], Frédéric Perros[2], Peter Dorfmüller[4] [1]Department of Cardiovascular Medicine, Tohoku University Graduate School of [1]Department of Pulmonary Diseases, VU University Medical Center, Institute for Medicine ~ Sendai ~ Japan, [2]Department of Medical Life Systems, Faculty of Life and Cardiovascular Research ~ Amsterdam ~ Netherlands, [2]INSERM UMR_S 999, Medical Sciences, Doshisha University ~ Kyoto ~ Japan, [3]Department of Thoracic Pulmonary Hypertension: Pathophysiology and Novel Therapies, Hôpital Marie Surgery, Fujita Health University School of Medicine ~ Aichi ~ Japan, [4]Department of Lannelongue ~ Paris ~ France, [3]National Reference Center of Pulmonary Hypertension, Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University ~ Department of Pulmonology and Intensive Care Unit for Respiratory Diseases, Hôpital Sendai ~ Japan Bicêtre, AP-HP, Kremlin-Bicêtre ~ Paris ~ France, [4]Department of Pathology, Hôpital Marie Lannelongue ~ Paris ~ France, [5]Department of Thoracic and Vascular Surgery, A29 ALTERED BMP SIGNALING BY ENDOTHELIN-1 TO ACCELERATE Hôpital Marie Lannelongue ~ Paris ~ France, [6]Department of Clinical Genetics, hôpital PROLIFERATION OF SMOOTH MUSCLE CELLS Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris and UMR_S 1166-ICAN, INSERM, UPMC Sorbonne Universités ~ Paris ~ France Hidekazu Maruyama*[2], Satoshi Sakai[1], Kazutaka Aonuma[1] [1]University of Tsukuba ~ Tsukuba ~ Japan, [2]Moriya Daiichi General Hospital ~ Moriya A34 WIDE COMPARATIVE STUDY ON ANTIPROLIFERATIVE VS ~ Japan VASODILATOR EFFECTS OF DRUGS USED FOR PULMONARY A30 SMOOTH MUSCLE PRIMES ENDOTHELIUM FOR HYPERTENSION IN RAT AND HUMAN ARTERIES REGENERATION BY LINKING METABOLISM TO EPIGENETICS Francisco Perez-Vizcaino*[1], Daniel Morales-Cano[1], Bianca Barreira[2], Laura [2] [2] [1] Kazuya Miyagawa*, Minyi Shi, Pin-I Chen, Jan Hennigs, Zhixin Zhao, Mouer Moreno , Joan A Barbera , Angel Cogolludo [1] [2] Wang, Caiyun Li, Toshie Saito, Shalina Taylor, Silin Sa, Aiqin Cao, Lingli Wang, Universidad Complutense ~ Madrid ~ Spain, Ciberes ~ Madrid ~ Spain Michael Snyder, Marlene Rabinovitch Stanford Universtiy School of Medicine ~ Stanford ~ United States of America

17 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOLOGY AND PATHOBIOLOGY

A35 GUT-LUNG CONNECTION IN PULMONARY ARTERIAL A38 LUNG CANCER–ASSOCIATED PULMONARY HYPERTENSION: HYPERTENSION ROLE OF MICROENVIRONMENTAL INFLAMMATION BASED ON Frederic Perros*[1], Benoit Ranchoux[1], Amélie Bigorgne[2], Aurélie TUMOR CELL-IMMUNE CELL CROSSTALK Hautefort[1], Barbara Girerd[3], Olivier Sitbon[3], David Montani[3], Marc Soni Pullamsetti*[1], Rajkumar Savai[1], Baktybek Kojonazarov[2], Samantha Humbert[3], Colas Tcherakian[4] Storn[1], Henning Gall[2], Ylia Salazar[1], Janine Wolf[3], Andreas Weigert[4], [1]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Nefertiti El-Nikhely[1], Ardeschir Ghofrani[2], Gabriele Krombach[3], Ludger Médecine, Université Paris-Saclay ~ Le Plessis Robinson ~ France, [2]UPMC UMRS Fink[5], Stefan Gattenlöhner[6], Ulf Rapp[1], Ralph Schermuly[2], Friedrich CR7 – Inserm U1135 – CNRS ERL 8255 ~ Paris ~ France, [3]INSERM UMR-S 999, Hôpital Grimminger[2], Werner Seeger[2] Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- [1]Max Planck Institute for Heart and Lung Research, Department of Lung Development HP Assistance Publique-Hôp de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le and Remodeling, member of the German Center for Lung Research (DZL) ~ Bad Kremlin-Bicêtre ~ France, [4]Service de Pneumologie, Hôpital Foch ~ Suresnes ~ France WORLD Nauheim ~ Germany, [2]Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen A36 DASATINIB INCREASES ENDOTHELIAL PERMEABILITY LEADING [3] SYMPOSIUM ~ Germany, Department of Radiology, Universities of Giessen and Marburg Lung ON TO PLEURAL EFFUSION Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen ~ Germany, [4] Carole Phan*[1], Etienne-Marie Jutant[1], Ly Tu[1], Raphael Thuillet[1], Andrei Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt ~ Frankfurt [5] [6] PULMONARY Seferian[1], David Montani[1], Alice Huertas[1], Jan Van Bezu[2], Fabian Breijer[2], ~ Germany, Institute of Pathology and Cytology, UEGP ~ Wetzlar ~ Germany, Anton Vonk Noordegraaf[3], Marc Humbert[1], Jurjan Aman[4], Christophe Department of Pathology, Universities of Giessen and Marburg Lung Center (UGMLC), member of the DZL, Justus Liebig University ~ Giessen ~ Germany HYPERTENSION Guignabert[1] [1]INSERM UMR_S999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre A39 MITOMYCIN C INDUCES PULMONARY HYPERTENSION AND [2] ~ France, VU University Medical Center, Department of Physiology ~ Amsterdam ~ PATHOLOGIC SIGNS OF PULMONARY VASCULAR OCCLUSIVE Netherlands, [3]Department of Pulmonary Disease, Institute of Cardiovascular Research ~ Amsterdam ~ Netherlands, [4]VU University Medical Center, Department of Physiology DISEASE IN RABBITS Nice [1] [2] [2] February 27-28 / March 1, 2018 and Department of Pulmonary Disease, Institute of Cardiovascular Research ~ Rozenn Quarck* , Allard Wagenaar , Birger Tielemans , Aurélie Amsterdam ~ Netherlands Hautefort[3], Catharina Belge[1], Fabrice Antigny[3], David Montani[3], Marion Delcroix[1], Frédéric Perros[3] A37 SHOULD WE CONSIDER PIRFENIDONE IN THE TREATMENT OF [1]KU Leuven and University Hospitals Leuven ~ Leuven ~ Belgium, [2]KU Leuven ~ PULMONARY ARTERIAL HYPERTENSION? Leuven ~ Belgium, [3]INSERM and University Paris-Sud ~ Le Plessis Robinson ~ France Paul-Benoit Poble*, Ghigna Maria Rosa, Phan Carole, Tu Ly, Bordenave Jennifer, Cumont Amélie, Thuillet Raphaël, Huertas Alice, Humbert Marc, A40 TRICHLOROETHYLENE-INDUCED PERMEABILITY OF THE Dorfmüller Peter, Guignabert Christophe PULMONARY VASCULAR ENDOTHELIUM: A ROLE IN THE INSERM UMR_S 999 / Université Paris-Sud / Université Paris-Saclay ~ Le Kremlin-Bicêtre DEVELOPMENT OF PULMONARY VENO-OCCLUSIVE DISEASE? ~ France Marianne Riou*[1], Morad Nakhleh[2], Florence Lecerf[2], Marc Humbert[1], David Montani[1], Frederic Perros[2] [1]INSERM UMR-S 999, Hôpital Marie Lannelongue, Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP- HP Assistance Publique-Hôpital de Paris, Service de Pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]INSERM UMR-S 999, Hôpital Marie Lannelongue. Univ. Paris- Sud, Faculté de Médecine, Université Paris- Saclay ~ Le Plessis Robinson ~ France A41 BLOCKADE OF ENDOTHELIN RECEPTOR TYPE B PROMOTE APOPTOSIS IN HUMAN PULMONARY ARTERIAL SMOOTH MUSCLE CELLS Satoshi Sakai*, Hidekazu Maruyama, Taizo Kimura, Junya Honda, Kazuya Otsu, Satoshi Homma, Takashi Miyauchi, Kazutaka Aonuma University of Tsukuba ~ Tsukuba ~ Japan

18 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOLOGY AND PATHOBIOLOGY

A42 SHEAR-MEDIATED ERYTHROCYTE NITRIC OXIDE PRODUCTION A47 LONG NONCODING RNA TYKRIL PLAYS A ROLE IN PULMONARY IS DIFFERENTIALLY REGULATED IN PATIENTS WITH SICKLE CELL HYPERTENSION BY CONTROLLING THE P53 MEDIATED DISEASE REGULATION OF PDGFRß Jacqueline Szmuszkovicz*, Silvie Suriany, Derek Ponce, Jon Detterich Chanil Valasarajan*[1], Christoph Zehendner[2], Serge Thal[3], Astrid Werner[2], [2] [2] [2] [2] Children’s Hospital Los Angeles ~ Los Angeles ~ United States of America Jes-Niels Boeckel , Florian Bischoff , David John , Tyler Weirick , Simone Glaser[2], Oliver Rossbach[4], Nicolas Jaé[2], Shemsi Demolli[2], A43 THE SIX-TRANSMEMBRANE PROTEIN STAMP2 PROTECTS FROM Regina Hummel[3], Karl-Friedrich Kreitner[5], Christian Möllmann[3], Katharina PULMONARY HYPERTENSION VIA ACTIONS IN MONONUCLEAR Michalik[2], Wei Chen[6], Werner Seeger[1], Shizuka Uchida[2], Andreas Zeiher[7], CELLS Stefanie Dimmeler[2], Soni Pullamsetti[1] [1] Henrik Ten Freyhaus*, Mahreen Batool, Eva Berghausen, Marius Vantler, Max Planck Institute for Heart and Lung Research, Department of Lung Development Stephan Rosenkranz and Remodeling, member of 13 the German Center for Lung Research (DZL) ~ Bad WORLD Nauheim ~ Germany, [2]Institute for Cardiovascular Regeneration, Centre for Molecular Klinik III for Internal Medicin, Heart Center of the University of Cologne ~ Cologne ~ Medicine, Goethe University Frankfurt am Main ~ Frankfurt am Main ~ Germany, [3] SYMPOSIUM Germany Department of Anesthesiology, University Medical Center Mainz ~ Mainz ~ Germany, ON [4]Institute of Biochemistry, University of Giessen ~ Giessen ~ Germany, [5]Department A44 PHENOTYPING OF PULMONARY ARTERIAL ENDOTHELIAL of Radiology, University Medical Center Mainz ~ Mainz ~ Germany, [6]Department of PULMONARY CELLS ISOLATED FROM PATIENTS WITH IDIOPATHIC Biology, Southern University of Science and Technology ~ Guangdong ~ China, [7]ZIM PULMONARY ARTERIAL HYPERTENSION AT DIAGNOSIS III, Department of Cardiology, Goethe University ~ Frankfurt am Main ~ Germany HYPERTENSION Birger Tielemans*[1], Allard Wagenaar[1], Mathias Leys[2], Catharina Belge[2], [2] [1] A48 SEX HORMONE PROFILES PREDICT THE RISK AND SEVERITY OF Marion Delcroix , Rozenn Quarck DISEASE IN POST-MENOPAUSAL WOMEN WITH PULMONARY [1]KU Leuven ~ Leuven ~ Belgium, [2]UZ leuven ~ Leuven ~ Belgium ARTERIAL HYPERTENSION [1] [1] [2] [3] Nice A45 BMPRII DRIVEN RESPONSE OF ENDOTHELIAL INTEGRITY Corey Ventetuolo* , Grayson Baird , R Graham Barr , David Bluemke , February 27-28 / March 1, 2018 Andrew Foderaro[1], Jason Fritz[4], Nicholas Hill[5], James Klinger[1], Joao AND ANGIOGENESIS IN HUMAN LUNG MICROVASCULAR [6] [6] [4] [7] ENDOTHELIAL CELLS Lima , Pamela Ouyang , Harold Palevsky , Amy Palmisciano , Diane Pinder[4], Ioana Preston[5], Thomas Walsh[7], Kari Roberts[5], Steven Kawut[4] [1] [1] [1] [1] Birger Tielemans* , Rik Gijsbers , Annelies Michiels , Allard Wagenaar , [1] [2] [1] [2] [2] [1] Brown University ~ Providence ~ United States of America, Columbia University Richard Farré Marti , Catharina Belge , Marion Delcroix , Rozenn Quarck ~ New York ~ United States of America, [3]National Institutes of Health ~ Bethesda ~ [1]KU Leuven ~ Leuven ~ Belgium, [2]UZ leuven ~ Leuven ~ Belgium United States of America, [4]University of Pennsylvania ~ Philadelphia ~ United States of America, [5]Tufts University ~ Boston ~ United States of America, [6]Johns Hopkins ~ A46 CONTRIBUTION OF BMP9 TO PULMONARY ARTERIAL Baltimore ~ United States of America, [7]Rhode Island Hospital ~ Providence ~ United HYPERTENSION: ROLE OF ENDOTHELIN-1 States of America Ly Tu*[3], Ayumi Sekine[3], Christine Mallet[2], Jennifer Bordenave[3], [2] [3] [3] [3] A49 PLATELET FUNCTION ABNORMALITIES IN PULMONARY Agnès Castan , Raphael Thuillet , Carole Phan , Paul-Benoit Poble , HYPERTENSION Jean-Jacques Feige[1], Alice Huertas[3], Marc Humbert[3], Sabine Bailly[2], Christophe Guignabert[3] Eleni Vrigkou*, Iraklis Tsangaris, Argyrios Tsantes, Dimitrios Konstantonis, Athanasios Pappas, Frantzeska Frantzeskaki, Michalis Rizos, Stylianos [1]Inserm U1036 ~ Grenoble ~ France, [2]Inserm UMR_S 1036 ~ Grenoble ~ France, [3] Inserm UMR_S 999 ~ Paris ~ France Orfanos, Apostolos Armaganidis Attikon University Hospital ~ Athens ~ Greece A50 RECEPTOR TYROSINE KINASE SIGNALING DRIVING “PSEUDO- MALIGNANT” LUNG VASCULAR REMODELING - THERAPEUTIC EXPLOITATION Naga Dinesh Reddy Yerabolu* Justus Liebig university Giessen ~ Giessen ~ Germany

19 POSTER SESSIONS

Tuesday, February 27, 2018 GENETICS AND GENOMICS

A51 THE UNITED STATES PULMONARY HYPERTENSION SCIENTIFIC A54 FIRST IDENTIFICATION OF KRÜPPEL-LIKE FACTOR 2 MUTATION REGISTRY (USPHSR): DESIGN AND INITIAL BASELINE IN HERITABLE PULMONARY ARTERIAL HYPERTENSION CHARACTERISTICS Christina Eichstaedt*[1], Jie Song[1], Rebecca Rodríguez Viales[2], Zixuan Pan[1], David Badesch*[1], Adaani Frost[4], Eric Austin[2], Jessica Badlam[1], Ray Nicola Benjamin[1], Christine Fischer[3], Marius Hoeper[4], Silvia Ulrich[5], Katrin Benza[5], Wendy K. Chung[6], Harrison Farber[7], Kathy Feldkircher[9], Bill Hinderhofer[3], Ekkehard Grünig[1] Nichols[8], Abby Poms[10], Chang Yu[2], C Greg Elliott[3] [1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelb [2] [1]University of Colorado ~ Denver ~ United States of America, [2]Vanderbilt University ~ Heidelberg ~ Germany, European Molecular Biology Laboratory ~ Heidelberg [3] ~ Nashville ~ United States of America, [3]Intermountain Medical Center, University of ~ Germany, Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ [4] [5] Utah ~ Murray ~ United States of America, [4]Houston Methodist Hospital and Weill Germany, Hannover Medical School, Clinic for Pneumology ~ Hannover ~ Germany, Cornell Medical College ~ Houston ~ United States of America, [5]Allegheny Hospital Clinic of Pulmonology, University Hospital Zurich ~ Zurich ~ Switzerland ~ Pittsburgh ~ United States of America, [6]Columbia University ~ New York ~ United WORLD States of America, [7]Boston University ~ Boston ~ United States of America, [8]Cincinatti A55 COMMON GENETIC BASIS FOR PULMONARY ARTERIAL SYMPOSIUM Children’s Hospital ~ Cincinatti ~ United States of America, [9]ESquared Trials ~ Half HYPERTENSION AND HIGH ALTITUDE PULMONARY EDEMA [10] ON Moon Bay ~ United States of America, ESquared Trials ~ United States of America Christina Eichstaedt*[1], Heimo Mairbäurl[2], Jie Song[1], Nicola Benjamin[1], [3] [3] [1] A52 DISCOVERY OF VASCULAR CELL-SPECIFIC EPIGENOMIC Christine Fischer , Katrin Hinderhofer , Ekkehard Grünig PULMONARY [1] SIGNATURES, NOVEL TRANSCRIPTION FACTORS AND Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [2]Medical Clinic VII, Sports Medicine, University of Heidelberg HYPERTENSION SIGNALING NETWORKS IN HUMAN PULMONARY ARTERIAL and Translational Lung Research Centre Heidelberg (TLRC), German Centre for Lung HYPERTENSION Research (DZL) ~ Heidelberg ~ Germany, [3]Institute of Human Genetics, Heidelberg Prakash Chelladurai*[1], Carsten Künne[1], Christine Weber[2], René Reiner University ~ Heidelberg ~ Germany Nötzold[2], Mario Schmoranzer[1], Mario Looso[1], Uta-Maria Bauer[2], Werner [1] [1] CLINICAL MANIFESTATION OF HEREDITARY PULMONARY Nice Seeger , Soni Savai Pullamsetti A56 February 27-28 / March 1, 2018 ARTERIAL HYPERTENSION BY A “SECOND HIT” MUTATION IN [1]Max-Planck Institute for Heart and Lung Research, Bad Nauheim ~ 61231 ~ Germany, [2]Institute of Molecular Biology and Tumor Research ~ Marburg ~ Germany THE GENES BMPR2 AND EIF2AK4 Christina Eichstaedt*[1], Jie Song[1], Rebecca Rodríguez Viales[2], Nicola A53 PREVALENCE AND CLINICAL FEATURES OF BONE Benjamin[1], Satenik Harutyunova[1], Christine Fischer[3], Katrin Hinderhofer[3], MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 MUTATION IN Ekkehard Grünig[1] KOREAN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION [1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg PATIENTS ~ Heidelberg ~ Germany, [2]European Molecular Biology Laboratory ~ Heidelberg [3] [1] [2] [1] [1] ~ Germany, Institute of Human Genetics, Heidelberg University ~ Heidelberg ~ Wook-Jin Chung* , Jun Soo Lee , Seungbum Choi , Seyeon Oh , Hanul Germany Choi[2], Kyung-Hee Kim[3], Kuk Hui Son[1], Hae Ok Jung[4], Jeongwon Ryu[1], Kyunghee Byun[1] [1]Department of Cardiovascular Medicine, Gachon Cardiovascular Research Institute ~ Incheon ~ Korea, Republic of, [2]Department of Cardiovascular Medicine, Gachon University Gil Medical Center ~ Incheon ~ Korea, Republic of, [3]Department of Cardiology, Sejong General Hspital ~ Bucheon ~ Korea, Republic of, [4]Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea ~ Seoul ~ Korea, Republic of

20 POSTER SESSIONS

Tuesday, February 27, 2018 GENETICS AND GENOMICS

A57 LANDSCAPE OF MUTATIONS FOUND BY GENE PANEL ROUTINE A58 NOVEL CAUSATIVE GENES FOR HERITABLE PULMONARY SEQUENCING FOR PULMONARY HYPERTENSION ARTERIAL HYPERTENSION Mélanie Eyries*[1], Anne Leroy[1], Barbara Girerd[2], David Montani[2], Marilyne Stefan Gräf*[1], Matthias Haimel[1], Marta Bleda[1], Charaka Hadinnapola[1], Levy[3], Damien Bonnet[3], Arnaud Bourdin[4], Romain Tresorier[5], Ari Wei Li[1], Joshua Hodgson[1], Bin Liu[1], Richard M Salmon[1], Mark Chaouat[6], Vincent Cottin[7], Céline Sanfiorenzo[8], Grégoire Prevot[9], Martine Southwood[2], Laura Southgate[3], Rajiv D Machado[4], Jennifer M Martin[1], Reynaud-Gaubert[12], Claire Dromer[10], Ali Houeijeh[11], Marc Humbert[2], Carmen M Treacy[1], Katherine Yates[1], Louise C Daugherty[1], Olga Florent Soubrier[1] Shamardina[1], Deborah Whitehorn[1], Simon Holden[5], Micheala A. Aldred[6], [7] [8] [9] [11] [1]Département de Génétique, Hôpital Pitié-Salpétrière, APHP ~ PARIS ~ France, [2]Centre Harm J Bogaard , Colin Church , Gerry Coghlan , Robin Condliffe , de référence de l’hypertension pulmonaire sévère, Service de pneumologie, Hôpital Paul A Corris[14], Cesare Danesino[15], Mélanie Eyries[16], Henning Gall[18], Bicêtre, APHP ~ Le Kremlin Bicêtre ~ France, [3]M3C-Cardiologie pédiatrique, Hôpital Stefano Ghio[19], Hossein-Ardeschir Ghofrani[18], J Simon R Gibbs[20], Necker-enfants malades, APHP ~ PARIS ~ France, [4]Département de pneumologie Barbara Girerd[21], Arjan C Houweling[7], Luke Howard[10], Marc Humbert[21], [5] WORLD et addictologie, CHU Arnaud de Villeneuve ~ Montpellier ~ France, Service de David G Kiely[11], Gabor Kovacs[23], Robert V Mackenzie Ross[17], Shahin cardiologie maladies vasculaires, CHU Gabriel Montpied ~ Clermont-Ferrand ~ France, Moledina[22], David Montani[21], Michael Newnham[1], Andrea Olschewski[6], SYMPOSIUM [6] Département de pneumologie, CHRU Nacy-Université de Lorraine ~ Vandoeuvre-les- [6] [8] [2] [7] Horst Olschewski , Andrew J Peacock , Joanna Pepke-Zaba , Inga ON nancy ~ France, Service de pneumologie, CHU Lyon HCL-GH Est-Hôpital Louis Pradel [10] [10] [19] [18] ~ Bron ~ France, [8]Service de pneumologie, Hôpital Pasteur, CHU Nice ~ Nice ~ France, Prokopenko , Christopher J Rhodes , Laura Scelsi , Werner Seeger , [16] [17] [1] [9]Service de pneumologie, Hôpital Larrey, CHU toulouse ~ Toulouse ~ France, [10]Service Florent Soubrier , Jay Suntharalingam , Emilia Swietlik , Mark R PULMONARY de pneumologie, CHU de Bordeaux, Hôpital Haut-lévêque ~ Bordeaux ~ France, [11] Toshner[1], Anton Vonk Noordegraaf[7], Quintin Waisfisz[7], John Wharton[10], Service de cardiologie infantile et congénitale, CHRU Lille-Hôpital cardiologique ~ Lille Stephen J Wort[10], Nicole Soranzo[13], Willem H Ouwehand[1], Allan Lawrie[11], HYPERTENSION ~ France, [12]Service de pneumologie, CHU Nord de Marseille, AP-HM, Aix- Marseille Paul D Upton[1], Richard C Trembath[12], Martin R Wilkins[10], Nicholas W Université ~ Marseille ~ France Morrell[1] [1]University of Cambridge ~ Cambridge ~ United Kingdom, [2]Papworth Hospital ~ Papworth ~ United Kingdom, [3]Molecular and Clinical Sciences Research Institute, St Nice George’s, University of London ~ London ~ United Kingdom, [4]University of Lincoln ~ February 27-28 / March 1, 2018 Lincoln ~ United Kingdom, [5]Addenbrooke’s Hospital ~ Cambridge ~ United Kingdom, [6]Cleveland Clinic ~ Cleveland, Ohio ~ United States of America, [7]VU University Medical Center ~ Amsterdam ~ Netherlands, [8]Golden Jubilee National Hospital ~ Glasgow ~ United Kingdom, [9]Royal Free Hospital ~ London ~ United Kingdom, [10] Imperial College London ~ London ~ United Kingdom, [11]Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital ~ Sheffield ~ United Kingdom,[12] King’s College London ~ London ~ United Kingdom, [13]Wellcome Trust Sanger Institute ~ Hinxton ~ United Kingdom, [14]University of Newcastle ~ Newcastle ~ United Kingdom, [15]Department of Molecular Medicine, University of Pavia ~ Pavia ~ Italy, [16]Département de génétique, hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, and UMR_S 1166-ICAN, INSERM, UPMC Sorbonne Universités ~ Paris ~ France, [17]Royal United Hospitals Bath NHS Foundation Trust ~ Bath ~ United Kingdom, [18]University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL) and of the Excellence Cluster Cardio-Pulmonary System (ECCCPS) ~ Giessen ~ Germany, [19]Fondazione IRCCS Policlinico San Matteo ~ Pavia ~ Italy, [20] National Heart & Lung Institute, Imperial College London ~ London ~ United Kingdom, [21]Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay; AP-HP, Service de Pneumologie, Centre de référence de l’hypertension pulmonaire; INSERM UMR_S 999, Hôpital Bicêtre, Le Kremlin-Bicêtre ~ Paris ~ France, [22]Great Ormond Street Hospital ~ London ~ United Kingdom, [23]Ludwig Boltzmann Institute for Lung Vascular Research ~ Graz ~ Austria

21 POSTER SESSIONS

Tuesday, February 27, 2018 GENETICS AND GENOMICS

A59 A SENSITIVE RESPONSE TO HYPOXIA IN PULMONARY ARTERY A61 ENHANCED EXPRESSION OF ENDOTHELIN-2, AN ISOPEPTIDE IN HIGH-ALTITUDE PULMONARY EDEMA SUSCEPTIBLE OF ENDOTHELIN-1, BY HYPOXIA IN LUNGS: POSSIBLE ROLE IN SUBJECTS UNDER A GENETIC BACKGROUND OF VARIATIONS PULMONARY HYPERTENSION IN THE EGLN1 GENE Yoko Suzuki*[1], Ikeda Koji[2], Miyagawa Kazuya[2], Tamada Naoki[1], Nakayama Nobumitsu Kobayashi*, Fumiya Kinota, Yunden Droma, Toshimichi Horiuchi, Kazuhiko[1], Yanagisawa Masashi[3], Emoto Noriaki[1] Atuhito Ushiki, Masanori Yasuo, Hiroshi Yamamoto, Masao Ota, Masayuki [1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Hanaoka University Graduate School of Medicine ~ Kobe ~ Japan, [2]Clinical Pharmacy, Kobe [3] Shinshu University School of Medicine ~ Matsumoto ~ Japan Pharmaceutical University ~ Kobe ~ Japan, International Institute for Integrative Sleep Medicine, University of Tsukuba ~ Tsukuba ~ Japan A60 KCNK3 CHANNEL INACTIVATION LEADS TO PULMONARY A62 THE EFFECTS OF BONE MORPHOGENETIC PROTEIN RECEPTOR WORLD VASCULAR ALTERATIONS IN RAT [1] [1] [2] [1] TYPE 2 MUTATION ON RIGHT VENTRICULAR FUNCTION IN SYMPOSIUM Mélanie Lambert* , Aurélie Hautefort , Boris Manoury , David Montani , PULMONARY ARTERIAL HYPERTENSION AFTER OPTIMAL Marc Humbert[1], Frédéric Perros[1], Fabrice Antigny[1] ON COMBINATION THERAPY [1]U999 ~ Le plessis Robinson ~ France, [2]U1180 ~ Chatenay Malabry ~ France PULMONARY Hiraide Takahiro*[1], Murata Mitsushige[2], Kataoka Masaharu[1], Aimi Yuki[3], Isobe Sarasa[1], Kawakami Takashi[1], Moriyama Hidenori[1], Endo Jin[1], HYPERTENSION Itabashi Yuji[1], Gamou Shinobu[3], Fukuda Keiichi[1] [1]Department of Cardiology, Keio University School of Medicine ~ Tokyo ~ Japan, [2] Department of Laboratory Medicine, School of Medicine, Keio University ~ Tokyo ~ Japan, [3]Second Department of Internal Medicine, Kyorin University School of Medicine ~ Tokyo ~ Japan Nice February 27-28 / March 1, 2018

PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATION

A63 INHIBITION OF NITRIC OXIDE SYNTHASE UNMASKS POTENT A65 THE OMEGA-3 EPA: DHA 6:1 FORMULATION PREVENTS THE VASOCONSTRICTION IN ESTABLISHED PULMONARY ARTERIAL MONOCROTALINE-INDUCED PULMONARY HYPERTENSION, HYPERTENSION PULMONARY ARTERY REMODELING AND ENDOTHELIAL Kohtaro Abe*, Mariko Tanaka, Hiroyuki Tsutsui DYSFUNCTION, AND RIGHT VENTRICULAR FAILURE IN RATS Kyushu University Graduate School of Medical Sciences ~ Fukuoka ~ Japan Said Amissi*[1], Zahid Rasul Niazi[1], Mélanie Burban[1], Romain Kessler[2], Mathieu Canuet[3], Florence Toti[1], Laurent Monassier[4], Nelly Boehm[5], Cyril A64 DIMINISHED RIGHT VENTRICULAR FUNCTION AT DIAGNOSIS Auger[1], Ferhat Meziani[2], Valérie Schini-Kerth[1] OF PULMONARY HYPERTENSION IS ASSOCIATED WITH [1]UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de MORTALITY IN BRONCHOPULMONARY DYSPLASIA Pharmacie, Université de Strasbourg ~ Strasbourg ~ France, [2]EA 7293, Stress vasculaire Gabriel Altit*, Shazia Bhombal, Jeffrey Feinstein, Theresa Tacy et tissulaire en transplantation, Fédération de médecine translationnelle de Strasbourg, Faculté de Pharmacie, université de Strasbourg ~ Strasbourg ~ France, [3]Pneumologie- Stanford University ~ Palo Alto ~ United States of America addictologie clinique, 5101 Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg ~ Strasbourg ~ France, [4]EA 7296, Laboratoire de Neurologie et Pharmacologie cardiovasculaire, Fédération de médecine translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg ~ Strasbourg ~ France, [5]Institut d’histologie et INSERM U1119, Fédération de médecine translationnelle de Strasbourg, Faculté de Médecine, Université de Strasbourg, France ~ Strasbourg ~ France

22 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATION

A66 ALTERATION OF KCNK3 FUNCTION CONTRIBUTES TO RIGHT A71 PULMONARY VASCULAR RESISTANCE AND COMPLIANCE VENTRICULAR DYSFUNCTIONS IN EXPERIMENTAL PULMONARY RELATIONSHIP IN PULMONARY HYPERTENSION: DIRECT HYPERTENSION MEASUREMENTS VERSUS EMPIRIC FORMULAE Fabrice Antigny*[1], Mélanie Lambert[1], Angèle Boet[1], Catherine Rucker- Christian Gerges*[1], Mario Gerges[1], Pierre Fesler[2], Anna Maria Pistritto[3], Martin[1], Véronique Capuano[1], Stéphane Hatem[2], Aurélie Hautefort[1], Jean- David Celermajer[4], Irene Lang[1] [3] [1] [1] [4] Baptiste Michel , Peter Dorfmüller , Elie Fadel , Tom Kotsimbos , Philippe [1]Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Jourdon[1], David Montani[1], Frédéric Perros[1], Marc Humbert[1] Medical University of Vienna ~ Vienna ~ Austria, [2]PhyMedExp, University of Montpellier, [1]INSERM U999 ~ LE PLESSIS ROBINSON ~ France, [2]UMRS-1166 INSERM ~ Paris ~ INSERM U1046, CNRS UMR 9214, and Department of Internal Medicine, Lapeyronie [3] France, [3]INSERM UMRS 1148 ~ Paris ~ France, [4]Dept. Respiratory Medicine, Alfred Hospital ~ Montpellier ~ France, Department of Internal Medicine, Division of [4] Hospital ~ Melbourne ~ Australia Cardiology, Ferrarotto Hospital, University of Catania ~ Catania ~ Italy, Department of Cardiology, Sydney Medical School, University of Sydney ~ Sydney ~ Australia WORLD A67 IMPAIRED RIGHT VENTRICULAR O2 DELIVERY IS ASSOCIATED WITH REDUCED RIGHT VENTRICULAR RESERVE IN PULMONARY A72 MIR-21 REGULATED RIGHT VENTRICULAR REMODELING SYMPOSIUM HYPERTENSION DURING EXERCISE SECONDARY TO PULMONARY ARTERIAL PRESSURE OVERLOAD ON [2] [1] [4] [3] Zongye Cai*, Richard Wb Van Duin, Dirk Jan Duncker, Daphne Merkus Chih-Hsin Hsu* , Hao-Chih Chang , Frederick Y Chen , Ronglih Liao [1]Chi-Mei Medical Center ~ Tainan ~ Taiwan, [2]Cheng Kung University Hospital ~ Tainan PULMONARY Erasmus MC ~ Rotterdam ~ Netherlands ~ Taiwan, [3]Brigham and Women’s Hospital ~ Boston ~ United States of America, [4]Tufts HYPERTENSION A68 PULMONARY ARTERIAL VOLUME, A DETERMINANT OF Medical Center ~ Boston ~ United States of America RESERVOIR FUNCTION MAY MODULATE RIGHT VENTRICULAR A73 ACTIVATED CONVENTIONAL DENDRITIC CELLS AS DRIVERS PERFORMANCE IN PATIENTS WITH PULMONARY ARTERIAL IN THE PATHOPHYSIOLOGY OF IDIOPATHIC PULMONARY HYPERTENSION ARTERIAL HYPERTENSION (IPAH)? Nice February 27-28 / March 1, 2018 Hao-Chih Chang*, Lu Dai-Yin, Sung Shih-Hsien Thomas Koudstaal*[1], Jennifer Van Hulst[1], Tridib Das[1], Peter Heukels[1], Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital ~ Daphne Merkus[2], Michiel De Raaf[2], Ingrid Bergen[1], Bogaard Harmjan[3], Taipei City ~ Taiwan Caetano Reis E Sousa[4], Geert Van Loo[5], Rudi Hendriks[1], Karin Boomars[1], Mirjam Kool[1] A69 ALTERED MYOCARDIAL ENERGY METABOLISM IN [1]Department of Pulmonary Medicine, Erasmus MC ~ Rotterdam ~ Netherlands, [2] EXPERIMENTAL RIGHT VENTRICULAR FAILURE ON ACUTE AND Department of Cardiology ~ Rotterdam ~ Netherlands, [3]Department of Pulmonary CHRONIC INCREASED AFTERLOAD Medicine, VUmc ~ Amsterdam ~ Netherlands, [4]Cancer research Centre UK, The Francis [5] Laurence Dewachter*[1], Asmae Belhaj[2], Benoit Rondelet[2], Francois Crick Institute ~ London ~ United Kingdom, VIB ~ Ghent ~ Belgium Kerbaul[1], Serge Brimioulle[1], Robert Naeije[1], Céline Dewachter[1] A74 EXERCISE HEMODYNAMIC PREDICTORS OF PEAK OXYGEN [1]Université Libre de Bruxelles ~ Brussels ~ Belgium, [2]Université Catholique de Louvain ~ Dinant ~ Belgium CONSUMPTION IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION A70 CORRELATION BETWEEN RIGHT VENTRICULAR FUNCTION Eloara Machado Ferreira*, Carolina M S Messina, Rudolf K F Oliveira, Angelo ASSESSED BY ECHOCARDIOGRAPHY AND BY RIGHT HEART X C Fonseca, Roberta P Ramos, Jaquelina S Ota-Arakaki CATHETERIZATION AMONG PATIENTS WITH PULMONARY Federal University of São Paulo (UNIFESP) ~ São Paulo ~ Brazil HYPERTENSION Juan Farina*[1], Augusto Lavalle Cobo[1], Hector Gomez Santa Maria[1], Diego A75 POTENTIAL ROLE OF THE ARYL HYDROCARBON RECEPTOR IN Crippa[1], Brenda Varela[3], Alfredo Hirschson Prado[2], Alejandro Nitsche[3], PAH Angeles Barth[1], Victor Daru[1], Adrian Lescano[1] Margaret Maclean*, Afshan Dean, Teja Gregorc, Craig Docherty [1]Finochietto Clinic ~ Buenos Aires ~ Argentina, [2]Hospital Rivadavia ~ Buenos Aires ~ University of Glasgow ~ Glasgow ~ United Kingdom Argentina, [3]Hospital Aleman ~ Buenos Aires ~ Argentina

23 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATION

A76 OSTEOPONTIN IN RIGHT VENTRICULAR REMODELING A81 THE RELATIONSHIP BETWEEN PULMONARY BLOOD FLOW Argen Mamazhakypov*, Akylbek Sydykov, Xia Tian, Kabita Pradhan, Astrid AND PULMONARY MICROVASCULAR RECRUITMENT IN SUPINE Weiß, Werner Seeger, Norbert Weissmann, Ardeschir Ghofrani, Ralph EXERCISING HUMANS Schermuly Stylianos Orfanos*[2], David Langleben[1], Michele Giovinazzo[1], Robert Excellence Cluster Cardio-Pulmonary System, University of Giessen ~ Giessen ~ Schlesinger[1], Fay Blenkhorn[1], John Catravas[3] Germany [1]Jewish General Hospital ~ Montreal ~ Canada, [2]Attikon Hospital ~ Athens ~ Greece, [3]Old Dominion University ~ Norfolk ~ United States of America A77 THE STIFFNESS OF THE PULMONARY ARTERY AS A MARKER OF RIGHT VENTRICULAR FUNCTION IN PATIENTS WITH A82 REGIONAL INHOMOGENEITY OF RIGHT VENTRICULAR PULMONARY HYPERTENSION CONTRACTION DURING HYPOXIC BREATHING BUT NOT WORLD Olga Moiseeva*, Maria Simakova, Anton Rygkov, Aigun Kyzymly DURING EXERCISE IN HEALTHY SUBJECTS Almazov National Medical Research Centre ~ Saint-Petersburg ~ Russian Federation Beatrice Pezzuto*[1], Kevin Forton[2], Vitalie Faoro[2], Yoshiki Motoji[2], Roberto SYMPOSIUM [3] [3] [5] [4] ON Badagliacca , Carmine Dario Vizza , Jean-Luc Vachiéry , Robert Naeije A78 THE CLINICAL VALUE OF ASSESSING RIGHT VENTRICULAR [1]Free University of Brussels-Dept of Exercise Physiology of the Faculty of Motor PULMONARY DIASTOLIC FUNCTION AFTER BALLOON PULMONARY Sciences; Sapienza University of Rome - Dept. of Cardiovascular and Respiratory ANGIOPLASTY IN PATIENTS WITH CHRONIC Sciences ~ Rome ~ Italy, [2]Free University of Brussels - Dept of Exercise Physiology of HYPERTENSION THROMBOEMBOLIC PULMONARY HYPERTENSION the Faculty of Motor Sciences ~ Brussels ~ Belgium, [3]Sapienza University of Rome - Dept of Cardiovascular and Respiratory Sciences ~ Rome ~ Italy, [4]Free University Hidenori Moriyama*, Mitsushige Murata, Toshimitsu Tsugu, Takashi of Brussels - Dept of Exercise Physiology of the Faculty of Motor Sciences; Erasme Kawakami, Masaharu Kataoka, Takahiro Hiraide, Mai Kimura, Sarasa Isobe, Academic Hospital - Dept of Cardiology ~ Brussels ~ Belgium, [5]Erasme Academic Jin Endo, Takashi Kohno, Yuji Itabashi, Keiichi Fukuda Hospital of Brussels, Dept of Cardiology ~ Brussels ~ Belgium Nice Keio University ~ Tokyo ~ Japan February 27-28 / March 1, 2018 A83 QUANTIFICATION AND VISUALIZATION OF PULMONARY A79 HIGH-SENSITIVE CARDIAC TROPONIN T LEVEL IS A SURROGATE VASCULAR RESPONSE TO NITRIC OXIDE USING COMPUTED MARKER FOR RV FUNCTIONAL RECOVERY AFTER SUCCESSFUL TOMOGRAPHY BALLOON PULMONARY ANGIOPLASTY IN PATIENTS WITH Farbod Rahaghi*[5], Tilo Winkler[2], Puja Kohli[3], Berta Marti Fuster[4], Ramya CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION Radhakrishnan[5], Tyler Blackwater[1], James Ross[4], Richard Channick[3], R [3] [4] [5] Mitsushige Murata*, Toshimitsu Tsugu, Takahiro Hiraide, Hidenori Moriyama, Scott Harris , Raúl San José Estépar , George Washko Mai Kimura, Sarasa Isobe, Takashi Kawakami, Masaharu Kataoka, Takashi [1]Harvard Medical School, Brigham and Women’s Hospital ~ Boston ~ United States of Kohno, Yuji Itabashi, Keiichi Fukuda America, [2]Harvard Medical School, Massachusetts General Hospital, Anesthesia, Critical Care and Pain Medicine ~ Boston ~ United States of America, [3]Harvard Medical School, Keio University ~ Tokyo ~ Japan Massachusetts General Hospital, Pulmonary and Critical Care ~ Boston ~ United States of America, [4]Harvard Medical School, Brigham and Women’s Hospital, Department of A80 WNT-SIGNALING PATHWAY DRIVES RIGHT VENTRICULAR Radiology ~ Boston ~ United States of America, [5]Harvard Medical School, Brigham and REMODELING Women’s Hospital, Division of Pulmonary and Critical Care ~ Boston ~ United States of Sreenath Reddy Nayakanti*[1], Aleksandra Tretyn[1], Swati Dabral[1], Mario America Böhm[2], Baktybek Kojonazarov[2], Wiebke Janssen[1], Werner Seeger[1], Ralph Schermuly[2], Soni Savai Pullamsetti[1] A84 ABNORMAL RESPONSE TO EXERCISE IN SYSTEMIC SCLEROSIS PATIENTS WITH NORMAL PULMONARY PRESSURES AT REST: A [1]Max-Planck-Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, [2] Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German CASE-CONTROLLED STUDY Center for Lung Research (DZL) ~ Giessen ~ Germany Asma Rimouche*[1], Sergio Caravita[1], Laurence Dewachter[2], Antoine Bondue[1], Jean Luc Vachiery[1] [1]Erasme-ULB ~ Brussels ~ Belgium, [2]ULB ~ Brussels ~ Belgium

24 POSTER SESSIONS

Tuesday, February 27, 2018 PATHOPHYSIOLOGY OF THE RV AND OF THE PULMONARY CIRCULATION

A85 ADAMTS8 PROMOTES THE DEVELOPMENT OF PULMONARY A87 TRANSITION FROM POST- TO COMBINED PRE/POST-CAPILLARY ARTERIAL HYPERTENSION AND RIGHT VENTRICULAR FAILURE PULMONARY HYPERTENSION: KEY ROLE OF ENDOTHELIN -A POSSIBLE NOVEL THERAPEUTIC TARGET- Richard WB van Duin*[1], Kelly Stam[1], Zongye Cai[1], Dirk Jan Duncker[1], Irwin Kimio Satoh*[1], Junichi Omura[1], Nobuhiro Kikuchi[1], Taijyu Satoh[1], Karl Reiss[2], Daphne Merkus[1] Ryo Kurosawa[1], Masamichi Nogi[1], Shinichiro Sunamura[1], Tomohiro [1]Erasmus MC ~ Rotterdam ~ Netherlands, [2]Sophia Children’s hospital ~ Rotterdam ~ Ohtsuki[1], Elias Al-Mamun[1], Mohammad Abdul Hai Siddique[1], Nobuhiro Netherlands Yaoita[1], Satoshi Miyata[1], Yasushi Hoshikawa[2], Yoshinori Okada[2], Hiroaki Shimokawa[1] [1]Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan, [2]Department of Thoracic Surgery, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan WORLD A86 RIGHT VENTRICULAR CHARACTERISTICS IN EISENMENGER SYMPOSIUM SYNDROME – ECG AND ECHO CORRELATIONS ON Tatiana Valkovicova*[1], Monika Kaldararova[1], Adriana Reptova[1], Marcela Bohacekova[1], Ljuba Bacharova[2], Robert Hatala[1], Iveta Simkova[1] PULMONARY [1]Department of Cardiology and Angiology, Slovak Medical University and National HYPERTENSION Institute of Cardiovascular Diseases ~ Bratislava ~ Slovakia, [2]International Laser Center ~ Bratislava ~ Slovakia

Nice February 27-28 / March 1, 2018 PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPS

A88 PULMONARY HYPERTENSION IN TAKAYASU ARTERITIS A90 RESULTS OF MEDIUM SEVEN YEARS’FOLLOW-UP IN SYSTEMIC Ali Akdogan*[1], Esra Firat[2], Yusuf Ziya Sener[3], Berkan Armagan[1], Metin SCLEROSIS PATIENTS WITH EXERCISE INDUCED PULMONARY Oksul[3], Serkan Asil[3], Vedat Hekimsoy[3], Abdulsamet Erden[1], Alper Sari[1] HYPERTENSION MEASURED DURING RIGHT HEART [1]Hacettepe University Faculty of Medicine, Department of Rheumatology ~ Ankara ~ CATHETERIZATION Turkey, [2]Hacettepe University Faculty of Medicine, Department of Internal Medicine ~ [3] Luciana D’Angelo*, Andrea Garascia, Eleonora Bruschi, Francesco Musca, Ankara ~ Turkey, Hacettepe University Faculty of Medicine, Department of Cardiology Oscar Massimiliano Epis, Antonella Moreo, Maria Frigerio ~ Ankara ~ Turkey ASST Grande Ospedale Metropolitano Niguarda ~ Milan ~ Italy A89 A COMPARISON OF NT-PROBNP LEVELS IN PATIENTS WITH SSC-ASSOCIATED PAH AND PATIENTS WITH SSC–RELATED PH A91 JOGJAKARTA CONGENITAL HEART DISEASE AND PULMONARY ASSOCIATED WITH LUNG DISEASE HYPERTENSION (COHARD-PH) STUDY: RESULTS FROM A SINGLE-CENTER NATIONAL REFERRAL HOSPITAL REGISTRY IN Sahachat Aueyingsak*, Wilaiwan Khrisanapant, Upa Kukongviriyapun, Orapin Pasurivong, Burabha Pussadhamma INDONESIA Faculty of Medicine, Khon Kaen University ~ Khon Kaen ~ Thailand Lucia Kris Dinarti*, Dyah Wulan Anggrahini, Anggoro Budi Hartopo Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Gadjah Mada - Dr Sardjito Hospital ~ Yogyakarta ~ Indonesia

25 POSTER SESSIONS

Tuesday, February 27, 2018 PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPS

A92 THE MORTALITY OF PREGNANT PATIENTS WITH UNCORRECTED A97 GENDER ASPECTS AMONG PATIENTS WITH IDIOPATHIC ATRIAL SEPTAL DEFECT IS INFLUENCED BY SEVERE PULMONARY ARTERIAL HYPERTENSION IN THE MODERN PULMONARY HYPERTENSION – A SUBSTUDY OF JOGJAKARTA TREATMENT ERA COHARD-PH REGISTRY Barbro Kjellström*[1], Clara Hjalmarsson[2], David Kylhammar[3], Sven-Erik Anggoro Budi Hartopo*, Dyah Wulan Anggrahini, Lucia Kris Dinarti Bartfay[2], Göran Rådegran[4], Magnus Nisell[5] Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas [1]Karolinska Institute ~ Stockholm ~ Sweden, [2]Sahlgrenska Universitetssjukhuset ~ Gadjah Mada ~ Yogyakarta ~ Indonesia Göteborg ~ Sweden, [3]Linköping Universitetssjukhus ~ Linköping ~ Sweden, [4]Skåne Universitetssjukhus ~ Lund ~ Sweden, [5]Karolinska Universityhospital ~ Stockholm ~ WORLD A93 PULMONARY HYPERTENSION IN ASIA: INSIGHTS FROM AN Sweden ASIAN TERTIARY REFERRAL CENTRE A98 CHARACTERISTICS OF PULMONARY ARTERIAL HYPERTENSION SYMPOSIUM [1] [1] [1] [1] Teng Yik Hoo* , Benjamin Chew , Jonathan Yap , Wen Ruan , Jeremy IN PATIENTS WITH SYSTEMIC SCLEROSIS AND ANTICENTRIOLE ON Teoh[1], Maggie Wong[1], Sewa Du Wen[2], Ghee Chee Phua[2], Andrea Low[3], [1] [1] AUTOANTIBODIES PULMONARY Ju Le Tan , Soo Teik Lim [1]Department of Cardiology, National Heart Centre Singapore ~ Singapore ~ Kana Kubota* HYPERTENSION Singapore, [2]Department of Respiratory Medicine, Singapore General Hospital ~ Department of Cardiovascular Medicine, Graduate School of Medicine, The University Singapore ~ Singapore, [3]Department of Rheumatology, Singapore General Hospital ~ of Tokyo ~ Bunkyo-ku, Tokyo ~ Japan Singapore ~ Singapore A99 PH EXPERIENCE IN A TERTIARY CENTER A94 THE DISPROPORTIONAL INCREASE OF PULMONARY PRESSURE Mehmet Serdar Kucukoglu*, Mert Palabiyik, Ozge Cetinarslan, Rengin Demir Nice IS RELATED TO THE CLINICAL OUTCOMES IN PATIENTS WITH Istanbul University Institute of Cardiology ~ Istanbul ~ Turkey February 27-28 / March 1, 2018 CHRONIC HEART FAILURE Wei-Ming Huang*, Shih-Hsien Sung A100 PULMONARY HYPERTENSION IN GREECE: PRELIMINARY DATA Taipei Veterans General Hospital ~ Taipei ~ Taiwan FROM A NATIONAL REGISTRY Athanasios Manginas*[9], Maria Toumpourleka[1], George Giannakoulas[1], A95 THE DETERMINANTS OF “OUT OF PROPORTION” PULMONARY Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], HYPERTENSION IN PATIENTS WITH MILD CHRONIC Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], OBSTRUCTION PULMONARY DISEASE Iraklis Tsangaris[3], Eleni Stagaki[3], Stylianos Orfanos[3], Georgia Pitsiou[4], [4] [5] [6] Wei-Ming Huang*, Shih-Hsien Sung Evangelia Panagiotidou , Ioanna Mitrouska , Ekaterini Avgeropoulou , Katerina Naka[7], Stavros Konstandinides[8], Anastasia Anthi[3] Department of Medicine, Taipei Veterans General Hospital ~ Taipei ~ Taiwan [1]Aristotle University of Thessaloniki ~ Thessaloniki ~ Greece, [2]Department of A96 IMPACT OF BLOOD VISCOSITY ON PULMONARY VASCULAR Cardiology, Onassis Cardiac Surgery Center ~ Athens ~ Greece, [3]Attikon University Hospital ~ Athens ~ Greece, [4]Respiratory Intensive Care Unit, Aristotle University of RESISTANCE IN PATIENTS ASSESSED FOR PULMONARY Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, [5]Pulmonary Department, HYPERTENSION AT A LARGE TERTIARY CENTRE University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Aleksander Kempny*, Konstantinos Dimopoulos, Colm Mccabe, Rafael Greece, [6]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [7] Alonso-Gonzalez, Laura Price, Michael Gatzoulis, Stephen J Wort Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Greece, [8]Cardiology Department, University Hospital of Alexandroupolis, Medical Royal Brompton Hospital ~ London ~ United Kingdom School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [9]Department of Cardiology, Mediterraneo Hospital ~ Athens ~ Greece

26 POSTER SESSIONS

Tuesday, February 27, 2018 PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPS

A101 PREVALENCE AND CORRELATES OF OBESITY IN PRECAPILLARY A103 THE BLOOD COUNT LEVELS, THE MEAN PULMONARY ARTERY PULMONARY HYPERTENSION PRESSURE AND SIX MINUTE WALK TEST AMONG ADULT Athanasios Manginas*[9], Maria Toumpourleka[1], George Giannakoulas[1], FILIPINOS WITH PULMONARY HYPERTENSION ASSOCIATED Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], WITH CONGENITAL HEART DISEASES: RESULTS FROM THE Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], PHILIPPINE HEART CENTER – CENTER FOR PULMONARY Iraklis Tsangaris[3], Eleni Stagaki[3], Stylianos Orfanos[3], Stylianos Orfanos[3], VASCULAR DISOR [4] [4] [5] Georgia Pitsiou , Evangelia Panagiotidou , Ioanna Mitrouska , Ekaterini Maria Paz Mateo* Avgeropoulou[6], Katerina Naka[7], Stavros Konstandinides[8], Anastasia Anthi[3] Philippine Heart Center ~ Quezon City ~ Philippines WORLD [1]Aristotle University of Thessaloniki ~ Thessaloniki ~ Greece, [2]Department of A104 COMPARISON OF CARDIAC OUTPUT DETERMINATION BY Cardiology, Onassis Cardiac Surgery Center ~ Athens ~ Greece, [3]Attikon University SYMPOSIUM [4] THE INDIRECT FICK AND THE THERMODILUTION METHOD IN Hospital ~ Athens ~ Greece, Respiratory Intensive Care Unit, Aristotle University of ON Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, [5]Pulmonary Department, PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Sophia Anastasia Mouratoglou*, Ioannis Doundoulakis, Feloukidis Cristos, PULMONARY Greece, [6]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [7] Bazmpani Maria Anna, Arvanitaki Alexandra, Toumpourleka Maria, Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Grosomanidis Vasileios, Hadjimiltiades Stavros, Karvounis Haralambos, HYPERTENSION Greece, [8]Cardiology Department, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [9]Department of Giannakoulas George Cardiology, Mediterraneo Hospital ~ Athens ~ Greece First Department of Cardiology, AHEPA University Hospital of Thessaloniki ~ Thessaloniki ~ Greece A102 ECHOCARDIOGRAPHIC ASSESSMENT OF RIGHT VENTRICULAR Nice COUPLING TO PULMONARY CIRCULATION IS ASSOCIATED A105 PULMONARY ARTERIAL HYPERTENSION IN IGG4-RELATED February 27-28 / March 1, 2018 WITH HEMODYNAMIC DISEASE SEVERITY IN PRECAPILLARY DISEASE: ALL ABOUT THE EPOPROSTENOL? PULMONARY HYPERTENSION Nicole Ruopp*, Harrison Farber Athanasios Manginas*[10], Maria Toumpourleka[1], George Giannakoulas[1], Boston University ~ Boston ~ United States of America Sofia-Anastasia Mouratoglou[1], Haralambos Karvounis[1], Eftihia Demerouti[2], Panagiotis Kariofillis[2], Georgios Athanasopoulos[2], Spyridon Rammos[2], A106 PULMONARY ARTERY DILATATION PROGRESS IN PATIENTS Spyridon Rammos[2], Spyridon Rammos[2], Iraklis Tsangaris[3], Eleni Stagaki[4], WITH PULMONARY HYPERTENSION COEXISTING PULMONARY Stylianos Orfanos[4], Georgia Pitsiou[5], Evangelia Panagiotidou[5], Evangelia ARTERY ANEURYSM - POSSIBLE INVOLVEMENT OF Panagiotidou[5], Ioanna Mitrouska[6], Ekaterini Avgeropoulou[7], Katerina PROSTAGLANDIN E RECEPTOR TYPE 4 OVEREXPRESSION- [8] [9] [4] Naka , Stavros Konstandinides , Anastasia Anthi Akagi Satoshi*[1], Nakamura Kazufumi[1], Yokoyama Utako[2], Kasahara [1]Department of Cardiology, AHEPA University Hospital, Aristotle University of Shingo[3], Sarashina Toshihiro[1], Ejiri Kentaro[1], Ito Hiroshi[1] [2] Thessaloniki ~ Thessaloniki ~ Greece, Department of Cardiology, Onassis Cardiac [1] [3] Department of Cardiovascular Medicine, Okayama University Graduate School of Surgery Center ~ Athens ~ Greece, 2nd Department of Critical Care Medicine, [2] [4] Medicine, Dentistry and Pharmaceutical Sciences ~ Okayama ~ Japan, Department National and Kapodistrian University of Athens ~ Athens ~ Greece, Pulmonary of Cardiovascular Research Institute, Yokohama City University Graduate School of Hypertension Clinic, Department of Critical Care, Attikon Hospital, National and Medicine ~ Yokohama ~ Japan, [3]Department of Cardiovascular Surgery, Okayama Kapodistirian University of Athens ~ Athens ~ Greece, [5]Respiratory Intensive Care Unit, [6] University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ~ Aristotle University of Thessaloniki, G.H. “G. Papanikolaou” ~ Thessaloniki ~ Greece, Okayama ~ Japan Pulmonary Department, University Hospital of Heraklion, Medical School, University of Crete ~ Heraklion ~ Greece, [7]Cardiology Department, Ippokrateio General Hospital ~ Athens ~ Greece, [8]Department of Cardiology, Medical School, University of Ioannina ~ Ioannina ~ Greece, [9]Cardiology Department, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace ~ Alexandroupolis ~ Greece, [10] Department of Cardiology, Mediterraneo Hospital ~ Athens ~ Greece

27 POSTER SESSIONS

Tuesday, February 27, 2018 PH HAEMODYNAMIC DEFINITIONS AND CLINICAL CLASSIFICATIONS AND CHARACTERISTICS OF SPECIFIC PAH SUBGROUPS

A107 DIFFERENTIAL INCREASE IN CIRCULATING PAN VEGF-A AND A109 CLINICAL CHARACTERISTICS AND SURVIVAL OF ASIAN VEGF-A165B LEVELS AMONG SUBTYPE OF PULMONARY PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION HYPERTENSION Jonathan Yap*[2], Teng Yik Hoo[2], Jeremy Teoh[2], Benjamin Chew[2], Duu Wen Shigetake Shimokata*[1], Kikuchi Ryosuke[2], Adachi Shiro[3], Okumura Naoki Sewa[1], Ghee Chee Phua[1], Andrea Low[3], Choong Hee Lim[2], Ju Le Tan[2], Okumura[3], Tajima Fumitaka[1], Kamimura Yoshihiro[1], Nakano Yoshihisa[1], Maggie Wong[2], Wen Ruan[2] Kondo Takahisa[3], Murohara Toyoaki[1] [1]Department of Respiratory Medicine, Singapore General Hospital ~ Singapore ~ [2] [1]Department of Cardiology, Nagoya University Graduate School of Medicine ~ Nagoya Singapore, Department of Cardiology, National Heart Centre Singapore ~ Singapore [3] ~ Japan, [2]Department of Medical Technique, Nagoya University Hospital ~ Nagoya ~ ~ Singapore, Department of Rheumatology, Singapore General Hospital ~ Singapore Japan, [3]Department of Advandced in Cardiopulmonary Disease, Nagoya University ~ Singapore WORLD Graduate School of Medicine ~ Nagoya ~ Japan SYMPOSIUM A110 THE STRUCTURAL-FUNCTIONAL STATE OF THE SYSTEMIC ON A108 SEVERE PULMONARY ARTERIAL HYPERTENSION IN PATIENTS CIRCULATION ARTERIES IN PATIENTS WITH PULMONARY TREATED BY CHINESE HERB NATURE INDIGO: QING-DAI ARTERIAL HYPERTENSION PULMONARY Yuichi Tamura*[1], Asuka Furukawa[1], Ly Tu[2], Christophe Guignabert[2], Marc Iryna Zhyvylo*, Yurii Sirenko, Ganna Radchenko [2] [3] [4] [5] HYPERTENSION Humbert , Noriaki Emoto , Hiroshi Watanabe , Koichiro Tatsumi SI «National Scientific Centre «M. D. Strazhesko Institute of Cardiology» of NAMS of [1]IUHW Mita Hospital ~ Tokyo ~ Japan, [2]South Paris University ~ Paris ~ France, [3]Kobe Ukraine» ~ Kyiv ~ Ukraine University ~ Kobe ~ Japan, [4]Hamamatsu University School of Medicine ~ Hamamatsu ~ Japan, [5]Chiba University ~ Chiba ~ Japan Nice February 27-28 / March 1, 2018 DIAGNOSIS OF PULMONARY HYPERTENSION

A111 DEATH OR RESOLUTION: THE NATURAL HISTORY OF A113 NONSYNDROMIC PERIPHERAL PULMONARY ARTERY PULMONARY HYPERTENSION IN BRONCHOPULMONARY STENOSIS IS ASSOCIATED WITH HOMOZYGOSITY OF RNF213 DYSPLASIA P.ARG4810LYS REGARDLESS OF CO-OCCURRENCE OF Gabriel Altit*, Shazia Bhombal, Theresa Tacy, Jeffrey Feinstein MOYAMOYA DISEASE Stanford University ~ Palo Alto ~ United States of America Sung-A Chang*, Ju Sun Song, Taek Kyu Park, Jung Hoon Yang, Woo Chan Kwon, So Ree Kim, Sung Mok Kim, Jihoon Cha, Shin Yi Jang, Young Seok A112 RECEPTOR TYROSINE KINASES AND RELATED LIGANDS Cho, Tae Jung Kim, Oh Young Bang, Jin Young Song, Chang Seok Ki, Duk- PROVIDE NEW PLASMA BIOMARKERS IN PULMONARY Kyung Kim ARTERIAL HYPERTENSION Samsung Medical Center, Sungkyunkwan University School of Medicine ~ Seoul ~ Habib Bouzina* Korea, Republic of ~ Lunds University - Lund - Sweden A114 CLINICAL PROFILING AND PREDICTING CLINICAL DETERIORATION IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTS IN A PULMONARY HYPERTENSION REFERENCE CENTER IN CAMPINAS-BRAZIL Mônica Corso Pereira*[1], Plínio José Whitaker Wolf[2] [1]Faculty of Medical Sciences of the State University of Campinas (Unicamp) ~ Campinas ~ Brazil, [2]Student of the Faculty of Medicine of Pontifical Catholic University of Campinas (Puccamp) ~ Campinas ~ Brazil 28 POSTER SESSIONS

Tuesday, February 27, 2018 DIAGNOSIS OF PULMONARY HYPERTENSION

A115 INCIDENCE OF PULMONARY HYPERTENSION AND A119 NAILFOLD VIDEOCAPILLAROSCOPY PARAMETERS AS A DETERMINING FACTORS IN PATIENTS WITH SYSTEMIC PREDICTORS OF PULMONARY ARTERIAL HYPERTENSION SCLEROSIS AFTER NEGATIVE RIGHT HEART CATHETERISATION DEVELOPMENT IN PATIENTS WITH SYSTEMIC SCLEROSIS Satenik Harutyunova*[2], Gerry Coghlan[1], Matthias Wolf[2], Oliver Distler[3], Nataliya Klyaus*, Maria Simakova, Kirill Malikov, Alexey Maslyanskiy, Olga Christopher P Denton[4], Martin Doelberg[5], Alberto Marra[2], Nicola Moiseeva [2] [6] [2] Benjamin , Christine Fischer , Ekkehard Grünig Federal State Budgetary Institution “V.A. Almazov National Medical Research Center” of [1]Cardiology Department, Royal Free Hospital, London ~ London ~ United Kingdom, [2] the Ministry of Health of the Russian Federation ~ Saint-Petersburg ~ Russian Federation Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany, [3]Department of Rheumatology, Faculty of Medicine, University A120 ACCURACY AND PRECISION OF MEAN PULMONARY PRESSURE of Zurich ~ Zürich ~ Switzerland, [4]Centre of Rheumatology, Royal Free Hospital, London ASSESSED BY ECHOCARDIOGRAPHY AMONG PATIENTS WITH [5] ~ London ~ United Kingdom, Actelion Pharmaceuticals Ltd., Gewerbestrasse 16, CH- PULMONARY HYPERTENSION WORLD 4123 Allschwil, Switzerland ~ Allschwil ~ Switzerland, [6]Institute of biostatistics University clinic Heidelberg ~ Heidelberg ~ Germany Adrian Lescano*, Juan Farina, Hector Gomez Santa Maria, Augusto Lavalle SYMPOSIUM Cobo, Guadalupe Romero, Nicolas Gonzalez, Miguel Gonzalez, Victor Daru, ON A116 PULMONARY HYPERTENSION IN ASIA: ESTIMATED Hugo Grancelli PREVALENCE AND PROGNOSIS FROM THE Finochietto Clinic ~ Buenos Aires ~ Argentina PULMONARY ECHOCARDIOGRAPHY COHORT HYPERTENSION Chih-Hsin Hsu*[2], Wei-Ting Chang[1], Hsiang-Yuan Chang[3], Wei-Shin Liu[4], A121 RAISING PAH AWARENESS IN SERBIA Wei-Da Lu[2] Senka Milutinov*, Ilija Andrijevic, Jovan Matijasevic, Ana Andrijevic [1]Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Institute for Pulmonary Diseases of Vojvodina ~ Sremska Kamenica ~ Serbia Yungkang Dist ~ Tainan ~ Taiwan, [2]Department of Internal Medicine,National Cheng [3] RIGHT HEART CATHETERIZATION FOR THE ASSESSMENT OF Nice Kung University ~ Tainan ~ Taiwan, National Cheng Kung University Hospital Dou-Liou A122 February 27-28 / March 1, 2018 Branch ~ Dou-Liou ~ Taiwan, [4]Tzu-Chi General Hospital ~ Hualien ~ Taiwan PULMONARY HYPERTENSION IN PATIENTS WITH INTERSTITIAL LUNG DISEASE A117 PREVALENCE OF PULMONARY HYPERTENSION IN PATIENTS [1] [2] [3] WITH SARCOIDOSIS: A SINGLE CENTER EXPERIENCE Nesrin Mogulkoc* , Hakan Kultursay , Bahri Akdeniz [1] [2] [1] [1] [1] [2] Ege University Hospital Pulmonology Department ~ Izmir ~ Turkey, Ege University Deniz Kaptan Ozen* , Bulent Mutlu , Alper Kepez , Derya Kocakaya , [3] [2] [1] [1] [1] Hospital, Cardiology Department ~ Izmir ~ Turkey, Dokuz Eylul University Hospital, Berrin Ceyhan , Batur Gonenc Kanar , Okan Erdogan , Halil Atas Cardiology Department ~ Izmir ~ Turkey [1]Marmara University Medical Faculty Cardiology Department ~ ISTANBUL ~ Turkey, [2] Marmara University Medical Faculty Pneumology Department ~ ISTANBUL ~ Turkey A123 EVALUATION OF CARDIAC FUNCTIONAL ALTERATIONS AND NATRIURETIC PEPTIDE LEVELS IN PATIENTS WITH SYSTEMIC A118 EFFICIENT DETECTION OF PULMONARY ARTERIAL SARCOIDOSIS HYPERTENSION USING SERUM HAPTOGLOBIN LEVEL AND Bulent Mutlu*[1], Deniz Kaptan Ozen[1], Alper Kepez[1], Derya Kocakaya[2], CARDIAC MRI IN PATIENTS WITH CONNECTIVE TISSUE Berrin Ceyhan[2], Okan Erdogan[1], Batur Gonenc Kanar[1], Halil Atas[1] DISEASES [1]Marmara University Medical Faculty Cardiology Department ~ ISTANBUL ~ Turkey, [2] [1] [1] [1] [1] Masaru Kato* , Hiroyuki Nakamura , Eri Sugawara , Yuichiro Fujieda , Marmara University Medical Faculty Pneumology Department ~ ISTANBUL ~ Turkey Kenji Oku[1], Toshiyuki Bohgaki[1], Shinsuke Yasuda[1], Hiroshi Ohira[2], Ichizo Tsujino[2], Masaharu Nishimura[2], Tatsuya Atsumi[1] [1]Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University ~ Sapporo ~ Japan, [2]First Department of Medicine, Hokkaido University Hospital ~ Sapporo ~ Japan

29 POSTER SESSIONS

Tuesday, February 27, 2018 DIAGNOSIS OF PULMONARY HYPERTENSION

A124 THE CONTRIBUTION OF ENDOTHELIAL CELLS TO THE VOLATOLOMIC SIGNATURE OF PAH Morad Nakhleh*[1], Salam Khatib[2], Ly Tu[1], Maria Vinhas[1], Barbara Girerd[1], Frederic Perros[1], David Montani[1], Raneen Jeries[2], Peter Dorfmuller[1], Elie Fadel[1], Christophe Guignabert[1], Marc Humbert[1], Hossam Haick[2], Sylvia Cohen-Kaminsky[1] [1]1Univ Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France. 2 AP-HP, DHU TORINO, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France. 3 Inserm UMR_S 999, LabExLERMIT, Hôpital Marie Lannelongue ~ Le Plessis Ro, [2]Department of Chemical Engineering and Russell Berrie Nanotechnology WORLD Institute, Technion–Israel Institute of Technology ~ Haifa ~ Israel SYMPOSIUM A125 CONGENITAL HEART DISEASES: A RARE REASON FOR ON PULMONARY HYPTERTENSION IN ADULT PATIENTS PULMONARY Gulfer Okumus*[1], Celik Sumer[1], Zuleyha Bingol[1], Gokcen Orhan[2], Murat Inanc[3], Ahmet Kaya Bilge[4] HYPERTENSION [1]Istanbul University Medical Faculty Department of Pulmonary Diseases ~ Istanbul ~ Turkey, [2]Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Department of Cardiovasculary Surgery ~ Istanbul ~ Turkey, [3] Istanbul University Medical Faculty Department of Rheumatology ~ Istanbul ~ Turkey, [4] Istanbul University Medical Faculty Department of Cardiology ~ Istanbul ~ Turkey Nice February 27-28 / March 1, 2018 A126 TUMOR MARKERS ARE ALTERED IN PLASMA FROM PULMONARY ARTERIAL HYPERTENSION PATIENTS Göran Rådegran*[1], Habib Bouzina[2] [1]Lund University ~ Lund ~ Sweden, [2]~ Sweden A127 PULMONARY HYPERTENSION (PH) DUE TO LEFT HEART DISEASE: A PREDICTIVE MODEL USING THE NATIONAL ECHO DATABASE OF AUSTRALIA (NEDA) Geoff Strange*[1], David Playford[1], Jim Codde[1], David Celermajer[2], Gregory Scalia[3], Kevin Chung[1] [1]The University of Notre Dame ~ Fremantle ~ Australia, [2]The University of Sydney ~ Sydney ~ Australia, [3]The University of Queensland ~ Brisbane ~ Australia A128 CT FUNCTIONAL PARAMETERS FOCUSING ON RVOT FOR PH Yi-Shan Tsai*[2], Hsu Chih-Hsin[1] [1]Department of Cardiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University ~ Tainan ~ Taiwan, [2]Department of Diagnostic Radiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University ~ Tainan ~ Taiwan

30 POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B10 EFFICACY OF ORAL IRON SUBSTITUTION IN NONANEMIC-IRON B15 INITIAL TREATMENT STRATEGY AND LONG-TERM SURVIVAL IN DEFICIENT PAH PATIENTS PULMONARY ARTERIAL HYPERTENSION (PAH) Bahri Akdeniz*, Ebru Özpelit, Dilek Sezgin, Bihter Sentürk, Can Sevinç, Resit Athénaïs Boucly*[1], Jason Weatherald[2], Laurent Savale[1], David Montani[1], Yigit Yilancioglu, Nezihi Baris Xavier JaÏs[1], Mitja Jevnikar[1], Gérald Simonneau[1], Marc Humbert[1], Olivier [1] No ~ Izmir ~ Turkey Sitbon [1]Université Paris-Sud, APHP, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2] B11 HOW EFFICACIOUS IS THE GUIDELINE BASED RISK Department of Medicine, Division of Respirology, University of Calgary ~ Calgary, AB ~ STRATIFICATION IN WHOLE PAH POPULATION IN ROUTINE Canada PRACTICE? B16 LONG-TERM OUTCOMES AND PREDICTORS OF SURVIVAL WORLD Bahri Akdeniz*, Ebru Özpelit, Dilek Sezgin, Can Sevinç, Nezihi Baris, Bihter IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION Sentürk SYMPOSIUM WITHOUT ACCESS TO PARENTERAL PROSTANOID THERAPY No ~ Izmir ~ Turkey ON Elena Dimitrova*[1], Arman Postadzhiyan[2], Bozhidar Finkov[2], Blagorodna B12 RELATIONSHIP BETWEEN BALANCE AND EXERCISE CAPACITY Karatancheva[2], Emilia Naseva[3], Vasil Velchev[2] PULMONARY IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION [1]National Heart Hospital ~ Sofia ~ Bulgaria,[2] University Hospital “Saint Anna” ~ Sofia ~ HYPERTENSION Bulgaria, [3]Medical University - Sofia ~ Sofia ~ Bulgaria Bahri Akdeniz*, Buse Ozcan Kahraman, Sema Savci, Ismail Ozsoy, Serap Acar, Ebru Ozpelit, Can Sevinc B17 IMPROVEMENT OF PULMONARY DIFFUSION CAPACITY AFTER Dokuz Eylul University ~ Izmir ~ Turkey INTRAVENOUS IRON SUBSTITUTION IN PATIENTS WITH IRON DEFICIENCY AND PULMONARY HYPERTENSION Nice B13 ROLE OF CARDIAC MAGNETIC RESONANCE IN STRATIFYING February 27-28 / March 1, 2018 THE PROGNOSIS OF PATIENTS WITH PULMONARY ARTERIAL Daniel Dumitrescu*, Tilmann Kramer, Henrik Hagmanns, Felix Gerhardt, HYPERTENSION Thomas Viethen, Stephan Baldus, Stephan Rosenkranz Herzzentrum der Universitaet zu Koeln ~ Cologne ~ Germany Alessandra Albini*, Fabio Dardi, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Enrico Monti, Elisa Zuffa, Daniele Guarino, Filippo Pasca, B18 CORRELATES OF WHO FUNCTIONAL CLASS IN PATIENTS WITH Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH Nazzareno Galiè CONGENITAL HEART DISEASE. RESULTS FROM CHALLENGE University of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy REGISTRY. Christos Feloukidis*[1], George Giannakoulas[1], Konstantinos Vasiliadis[2], B14 TRANSITION FROM SUBCUTANEOUS TREPROSTINIL TO Alexandra Frogoudaki[3], Christos Ntellos[4], Afroditi Tzifa[10], Styliani Brili[5], INTRAVENOUS THERMOSTABLE EPOPROSTENOL IN PATIENTS Athanasios Manginas[6], Despina Ntiloudi[1], Marios Kolios[7], Antonios Pitsis[8], WITH SEVERE PULMONARY ARTERIAL HYPERTENSION Haralambos Karvounis[1], Konstantinos Tsioufis[5], Spyridon Rammos[9] [1] [1] [1] [1]Cardiology Department, AHEPA University Hospital ~ Thessaloniki ~ Greece, [2] Anastasia Anthi* , Konstantina Ntai , Dimitrios Konstantonis , Frantzeska [3] [1] [2] [1] [2] Cardiology Department, G. Papanikolaou Hospital ~ Thessaloniki ~ Greece, Frantzeskaki , Eleni Stagaki , Cornelia Mitrakou , Athanasios Pappas , [4] [1] [1] [1] Cardiology Department, Attikon University Hospital ~ Athens ~ Greece, Cardiology Michalis Rizos , Olympia Apostolopoulou , Apostolos Armaganidis , [5] [1] Department, Tzaneio General Hospital of Piraeus ~ Athens ~ Greece, Cardiology Stylianos Orfanos Department, Hippokrateion University Hospital ~ Athens ~ Greece, [6]Cardiology [1]Pulmonary Hypertension Clinic and 2nd Department of Critical Care, University Department, Mediterraneo Hospital ~ Athens ~ Greece, [7]Cardiology Department, of Athens, “Attikon” Hospital ~ Athens ~ Greece, [2]Pulmonary Hypertension Clinic, University Hospital of Ioannina ~ Ioannina ~ Greece, [8]Department of Cardiothoracic University of Athens, “Attikon” Hospital ~ Athens ~ Greece Surgery, Saint Luke’s Clinic ~ Thessaloniki ~ Greece, [9]Department of Paediatric Cardiology and ACHD, Onassis Cardiac Surgery Centre ~ Athens ~ Greece, [10] Department of Congenital Heart Disease, Mitera Children’s Hospital ~ Athens ~ Greece

31 POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B19 EXERCISE CMR TO EVALUATE RV FUNCTION AND B22 SAFETY OF SWITCHING TO RIOCIGUAT FOR THE TREATMENT HEMODYNAMICS IN PAH: PILOT STUDY OF PULMONARY HYPERTENSION: DATA FROM THE EXPERT Veronica Franco*, Eks Wye Pollock, Subha Raman REGISTRY The Ohio State University ~ Columbus, Ohio ~ United States of America Ekkehard Grünig*[1], Henning Gall[2], Hossein-Ardeschir Ghofrani[2], Marc Humbert[3], Gérald Simonneau[3], Hans Klose[4], Michael Halank[5], David B20 INVESTIGATION OF HEPATIC FIBROSIS AS A NOVEL Langleben[6], Repke Snijder[17], Pilar Escribano[11], Lisa Mielniczuk[7], Tobias PROGNOSTIC FACTOR IN PATIENTS WITH PULMONARY Lange[10], Jean-Luc Vachiéry[8], Hubert Wirtz[9], Douglas Helmersen[12], ARTERIAL HYPERTENSION Iraklis Tsangaris[14], Joan Albert Barberá[15], Joanna Pepke-Zaba[13], Anco [16] [25] [26] [18] WORLD Asuka Furukawa*, Yuichi Tamura Boonstra , Stephan Rosenkranz , Sylvia Ulrich , Regina Mascherbauer , Marion Delcroix[19], Pavel Jansa[27], Miguel Angel Gómez Sánchez[20], Jens SYMPOSIUM International University of Health and Welfare Mita Hospital ~ Tokyo ~ Japan Klotsche[21], Christian Meier[22], David Pittrow[23], Marius M Hoeper[24] ON B21 AUDIT OF DISEASE TARGETED THERAPIES IN ADULT PATIENTS [1]Thoraxclinic at Heidelberg University Hospital ~ Heidelberg ~ Germany, [2]University of WITH PULMONARY ARTERIAL HYPERTENSION Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung PULMONARY Research (DZL) ~ Giessen ~ Germany, [3]Université Paris-Sud, Le Kremlin-Bicêtre, Service [1] [1] [1] [1] Wendy Gin-Sing* , Simon Gibbs , Luke Howard , Rachel Davies , George de Pneumologie, Centre de Référence de l’Hypertension Pulmonaire Sévère, DHU HYPERTENSION Villa[1], Margaret Lau-Walker[2], Geraldine Lee[2] Thorax Innovation, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [4]Section Pneumology, [5] [1]Hammersmith Hospital ~ London ~ United Kingdom, [2]King’s College ~ London ~ University Medical Center Hamburg-Eppendorf ~ Hamburg ~ Germany, Medical United Kingdom Clinic I, Department of Pneumology, University Hospital Carl Gustav Carus ~ Dresden ~ Germany, [6]Jewish General Hospital, McGill University ~ Montreal, Quebec ~ Canada, [7] Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute ~ Nice Ottawa ~ Canada, [8]Département de Cardiologie, Cliniques Universitaires de Bruxelles, February 27-28 / March 1, 2018 Hôpital Erasme ~ Brussels ~ Belgium, [9]Department of Respiratory Medicine, University of Leipzig ~ Leipzig ~ Germany, [10]Department of Internal Medicine II, Division of Pneumology, University Medical Center ~ Regensburg ~ Germany, [11]Department of Cardiology, Hospital 12 de Octubre ~ Madrid ~ Spain, [12]Alberta Health Services, University of Calgary ~ Calgary, Alberta, ~ Canada, [13]Pulmonary Vascular Disease Unit, Papworth Hospital ~ Cambridge ~ United Kingdom, [14]Second Department of Critical Care, University Hospital Attikon ~ Athens ~ Greece, [15]Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer and University of Barcelona ~ Barcelona ~ Spain, [16]VU Medisch Centrum ~ Amsterdam ~ Netherlands, [17]Department of Pulmonology, St Antonius Ziekenhuis ~ Nieuwegein ~ Netherlands, [18]Servicestelle für klinische Studien, Krankenhaus der Elisabethinen Linz GmbH ~ Linz ~ Austria, [19] Department of Pulmonology, Katholieke Universiteit ~ Leuven ~ Belgium, [20]Hospital General Nuestra Señora del Prado, Talavera de la Reina ~ CIBERES ~ Spain, [21]German Rheumatism Research Center Berlin, Leibniz Institute ~ Berlin ~ Germany, [22]Bayer AG, Global Development, Global Medical Affairs ~ Berlin ~ Germany, [23]Institute for Clinical Pharmacology, Medical Faculty, Technical University ~ Dresden ~ Germany, [24]Department of Respiratory Medicine and the German Center for Lung Research, Hannover Medical School ~ Hannover ~ Germany, [25]Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center ~ Cologne ~ Germany, [26]Klinik für Pneumologie, UniversitätsSpital Zürich ~ Zurich ~ Switzerland, [27]2nd Department of Medicine – Department of Cardiovascular Medicine, Charles University in Prague ~ Prague ~ Czech Republic

32 POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B23 RISK STRATIFICATIONS AND DEATHS IN ADULT UNCORRECTED B27 HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND ATRIAL SEPTAL DEFECT WITH PULMONARY HYPERTENSION: AN INFLAMMATORY MARKERS IN PREDICTION OF LONG-TERM INDONESIAN EXPERIENCE RESPONSIVENESS TO CALCIUM CHANNEL BLOCKERS Anggoro Budi Hartopo*, Dyah Wulan Anggrahini, Lucia Kris Dinarti IN PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL Department of Cardiology and Vascular Medicine Universitas Gadjah Mada/Sardjito HYPERTENSION General Hospital ~ Yogyakarta ~ Indonesia Kamil Jonas*, Marcin Waligora, Wojciech Magon, Jakub Stepniewski, Piotr Podolec, Grzegorz Kopec B24 INITIAL COMBINATION THERAPY WITH RIOCIGUAT AND Department of Cardiac and Vascular Diseases Jagiellonian University Medical College AMBRISENTAN IN PULMONARY ARTERIAL HYPERTENSION: A ~ Krakow ~ Poland WORLD PROSPECTIVE OPEN-LABEL STUDY Naushad Hirani*, Jason Weatherald, Doug Helmersen, Mitesh Thakrar, Rhea B28 OUTCOME OF COMPRESSION OF LEFT CORONANY SYMPOSIUM Varughese, Carmen Lydell, Nowell Fine ARTERY IN PATIENTS WITH SEVERE PULMONARY ARTERIAL ON University of Calgary ~ Calgary ~ Canada HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASES PULMONARY B25 IMPACT OF AGE AND COMORBIDITY ON OUTCOME IN Jo Won Jung*, Sang Eun Lee, Hyuk-Jae Chang, Se Yong Jung, Jae Young HYPERTENSION IDIOPATHIC PULMONARY HYPERTENSION: DATA FROM THE Choi, Yu Lim Shin, Han Ki Park, Young Hwan Park SWEDISH PULMONARY ARTERIAL HYPERTENSION REGISTRY Yonsei University College of Medicine ~ Seoul ~ Korea, Republic of Clara Hjalmarsson*[2], Göran Rådegran[1], David Kylhammar[3], Bengt Rundqvist[2], Jonas Multing[2], Magnus Nisell[4], Barbro Kjellström[4] B29 EARLY EXPERIENCE OF MACITENTAN FOR THE TREATMENT OF Nice [1]Department of Clinical Sciences, Cardiology, Lund University and Skåne University PULMONARY ARTERIAL HYPERTENSIONC WITH CONGENITAL February 27-28 / March 1, 2018 Hospital ~ Lund ~ Sweden, [2]Department of Cardiology, Sahlgrenska Academy, HEART DISEASES IN SINGLE CENTER. [3] Gothenburg University, and Sahlgrenska University Hospital ~ Göteborg ~ Sweden, Jo Won Jung*, Hyuk Jae Chang, Se Yong Jung, Jae Young Choi Department of Clinical Physiology and Department of Medicine and Health Sciences, Linköping University ~ Linköping ~ Sweden, [4]Cardiology Unit, Department of Yonsei University College of Medicine ~ Seoul ~ Korea, Republic of Medicine, Karolinska Institute ~ Stockholm ~ Sweden B30 CLINICAL COURSE OF INITIAL ORAL COMBINATION THERAPY B26 EFFICACY AND SAFETY OF EARLY SEQUENTIAL COMBINATION FOR THE TREATMENT OF PAH IN SYSTEMIC SCLEROSIS THERAPY WITH RIOCIGUAT AND ENDOTHELIN RECEPTOR Yasushi Kawaguchi*, Yuki Ichimura, Tomoaki Higuchi, Kae Takagi ANTAGONISTS IN PATIENTS WITH PULMONARY ARTERIAL Institute of Rheumatology, Tokyo Women’s Medical University ~ Tokyo ~ Japan HYPERTENSION: RESULTS FROM PATENT-1 AND PATENT-2 Marc Humbert*[1], Ekkehard Grünig[2], Pavel Jansa[3], Gérald Simonneau[1], B31 RAPID SEQUENTIAL COMBINATION THERAPY WITH PDE5 Franck Rahaghi[4], Stephan Rosenkranz[5], Dennis Busse[6], Christian Meier[7], INHIBITORS AND ENDOTHELIN RECEPTOR ANTAGONISTS Janethe De Oliveira Pena[8], Hossein-Ardeschir Ghofrani[9] SUBSTANTIALLY IMPROVES HEMODYNAMICS AT EARLY [1]Université Paris-Sud, Le Kremlin-Bicêtre, Service de Pneumologie, Centre de Référence FOLLOW-UP de l’Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre ~ Le Tilmann Kramer*, Daniel Dumitrescu, Felix Gerhardt, Phillip Nattmann, [2] Kremlin-Bicêtre ~ France, Centre for Pulmonary Hypertension, Thoraxclinic at Heidelberg Christopher Hohmann, Stephan Baldus, Stephan Rosenkranz University Hospital ~ Heidelberg ~ Germany, [3]Clinical Department of Cardiology and Angiology, 1st Faculty of Medicine, 2nd Medical Department, Charles University ~ Prague Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Germany ~ Cologne ~ ~ Czech Republic, [4]Department of Pulmonary and Critical Care Medicine, Cleveland Germany Clinic Florida, Weston ~ Florida ~ United States of America, [5]Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center ~ Cologne ~ Germany, [6]Chrestos Concept GmbH & Co. KG ~ Essen ~ Germany, [7]Bayer AG, Global Development, Global Medical Affairs ~ Berlin ~ Germany, [8]Bayer HealthCare Pharmaceuticals Inc, Whippany ~ New Jersey ~ United States of America, [9] University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany, member of the German Center for Lung Research (DZL) ~ Giessen ~ Germany 33 POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B32 HEMODYNAMIC AND HISTOPATHOLOGIC BENEFITS OF B38 SURVIVAL OF PATIENTS WITH PULMONARY HYPERTENSION –A EARLY TREATMENT WITH MACITENTAN IN A RAT MODEL OF SINGLE CENTER EXPERIENCE IN JAPAN- PULMONARY ARTERIAL HYPERTENSION Hiromi Matsubara*, Aiko Ogawa Kim Kyung-Hee*[2], Kim Hyung-Kwan[1] National Hospital Organization Okayama Medical Center ~ Okayama ~ Japan [1]Seoul National University Hospital ~ Seoul ~ Korea, Republic of, [2]Sejong General Hospital ~ Kyunggido ~ Korea, Republic of B39 MORTALITY IN PULMONARY ARTERIAL HYPERTENSION TRIALS: A COMPARISON BETWEEN META-ANALYSES B33 THE PROGNOSTIC VALUE OF DLCO AND PULMONARY BLOOD Enrico Monti*, Massimiliano Palazzini, Enrico Gotti, Fabio Dardi, Andrea WORLD FLOW IN PATIENTS WITH PULMONARY HYPERTENSION Rinaldi, Alesandra Albini, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita Tobias Lange*, Nicoletta Mergenthaler Tanese, Antonio Colangelo, Mariangela Rotunno, Alessandra Manes, SYMPOSIUM University Medical Center Regensburg ~ Regensburg ~ Germany Nazzareno Galiè ON University of Bologna, Department of Specialized, Diagnosticand Experimental B34 PULMONARY HYPERTENSION IN KOREAN PATIENTS WITH Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy PULMONARY CONNECTIVE TISSUE DISEASE: RESULTS FROM EXTENDED HYPERTENSION FOLLOW-UP OF A NATION-WIDE REGISTRY B40 PROGNOSTIC VALUE OF 12-LEAD ECG IN PATIENTS WITH Shin-Seok Lee*[2], Chan Hong Jeon[1], Han Ki Park[3] PRECAPILLARY PULMONARY HYPERTENSION [1]Soonchunhyang University Hospital ~ Bucheon ~ Korea, Republic of, [2]Chonnam Thomas Nguyen*, Jean-Luc Vachiéry, Rubén Casado-Arroyo National University Bitgoeul Hospital ~ Gwangju-Gwangyeoksi ~ Korea, Republic of, [3] Erasme University Hospital, Department of Cardiology ~ Brussels ~ Belgium Nice Severance Hospital, Yonsei University College of Medicine ~ Seoul ~ Korea, Republic of February 27-28 / March 1, 2018 B41 ALLERGIC TO ONE DOES NOT MEAN TO ALL B35 FUNCTIONAL CAPACITY USING SUBMAXIMAL EXERCISE TEST Zeki Ongen*, Burcak Kilickiran Avci, Hurrem Gul Ongen IS RELIABLE PREDICTOR FOR AGGRAVATION OF PULMONARY Cerrahpasa Medical Faculty ~ Istanbul ~ Turkey HYPERTENSION Byeong-Ju Lee*, Jung Hyun Choi B42 CARDIOPULMONARY EXCERCISE TEST IN PULMONARY Pusan national university hospital ~ Busan ~ Korea, Republic of ARTERIAL HYPERTENSION PATIENTS: LONGITUDINAL CHANGES IN THE MODERN MANAGEMENT ERA B36 CLINICAL EFFICACY OF MACITENTAN IN PATIENTS WITH Evangelia Panagiotidou*[1], Georgia Pitsiou[1], Evdokia Sourla[1], Sofia PULMONARY ARTERIAL HYPERTENSION: OUR EXPERIENCE IN Akritidou[1], Vasileios Bagalas[1], Afroditi Boutou[2], Ioannis Stanopoulos[1] ARGENTINA [1]Respiratory Failure Clinic, General Hospital of Thessaloniki “G.Papanikolaou”, Aristotle Adrian Lescano*[1], Nicolas Atamañuk[4], Vanesa Gregorietti[2], Nicolas University of Thessaloniki ~ THESSALONIKI ~ Greece, [2]Respiratory Clinic,General Caruso[5], Daniela Garcia Brasca[3], Maria Lorena Coronel[6], Juan Farina[1], Hospital of Thessaloniki “G.Papanikolaou”, Aristotle University of Thessaloniki ~ Sergio Perrone[2], Guillermo Bortman[5] THESSALONIKI ~ Macedonia, Former Yugoslav Republic of [1]Finochietto Clinic ~ Buenos Aires ~ Argentina, [2]Hospital El Cruce ~ Buenos Aires ~ B43 TREATMENT PATTERNS AND MEDICATION ADHERENCE AND Argentina, [3]Hospital Italiano ~ Cordoba ~ Argentina, [4]Hospital Fernandez ~ Buenos Aires ~ Argentina, [5]Sanatorio Mitre ~ Buenos Aires ~ Argentina, [6]Instituto Cabral ~ PERSISTENCE AMONG PATIENTS WITH PULMONARY ARTERIAL Corrientes ~ Argentina HYPERTENSION IN REAL-WORLD DATABASE REPRESENTING A LARGE US HEALTH PLAN B37 MEDICATION ADHERENCE AND RISK OF HOSPITALIZATION Janis Pruett*[2], Michael Hull[1], Eleena Koep[1], Yuen Tsang[2], William Drake[2] IN PULMONARY ARTERIAL HYPERTENSION (PAH) PATIENTS [1]Optum ~ Eden Prairie ~ United States of America, [2]Actelion Pharmaceuticals, US ~ TREATED WITH ENDOTHELIN RECEPTOR ANTAGONISTS (ERAS) South San Francisco ~ United States of America OR PHOSPHODIESTERASE TYPE 5 INHIBITORS (PDE5IS) Cassandra Lickert*[1], Jerrold Hill[2], Michele Cole[1], Rolin Wade[2], Yuen Tsang[1], William Drake[1] [1]Actelion Pharmaceutical ~ South San Francisco ~ United States of America, [2] 34 QuintilesIMS ~ Plymouth Meeting ~ United States of America POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B44 HEMODYNAMIC AND EXERCISE EFFECTS OF DIFFERENT TYPES B48 THE GOAL OF LONG-TERM OXYGEN THERAPY TO AVOID TISSUE OF INITIAL ORAL COMBINATION THERAPY IN PULMONARY HYPOXIA IN PATIENTS WITH PULMONARY HYPERTENSION ARTERIAL HYPERTENSION Rika Suda*, Nobuhiro Tanabe, Akira Naito, Rintaro Nishimura, Takayuki Jujo, Andrea Rinaldi*, Massimiliano Palazzini, Enrico Gotti, Fabio Dardi, Toshihiko Sugiura, Seiichiro Sakao, Koichiro Tatsumi Alessandra Albini, Enrico Monti, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno Galiè B49 DIVERSITY OF BORDERLINE PULMONARY ARTERIAL PRESSURE University of Bologna, Department of Specialized Diagnostic and Experimental ASSOCIATED WITH SYSTEMIC SCLEROSIS: 4 CASE SERIES Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy Eri Sugawara*[1], Masaru Kato[1], Ryo Hisada[1], Hiroyuki Nakamura[1], Fujieda WORLD Yuichiro[1], Kenji Oku[1], Toshiyuki Bohgaki[1], Shinsuke Yasuda[1], Hiroshi B45 INITIAL CLINICAL RESULTS WITH MACITENTAN IN CONGENITAL Ohira[2], Ichizo Tsujino[2], Masaharu Nishimura[2], Tatsuya Atsumi[1] SYMPOSIUM HEART DISEASE PATIENTS WITH PULMONARY ARTERIAL [1]Department of Rheumatology, Endocrinology and Nephrology, Graduate School ON HYPERTENSION of Medicine and Faculty of Medicine, Hokkaido University ~ Sapporo ~ Japan, [2]First Joaquín Rueda-Soriano*[1], Josep Lluís Melero-Ferrer[2], Carlos Israel Department of Medicine, Hokkaido University Hospital ~ Sapporo ~ Japan PULMONARY Chamorro-Fernández[3], Francisco Buendia-Fuentes[4], Ana Osa-Sáez[1], Luis HYPERTENSION Martínez-Dolz[1] B50 REAL LIFE EXPERIENCE WITH REVEAL RISK SCORE FOR [1]Servicio de Cardiología. Hospital Universitari i Politècnic La Fe, Valencia ~ Valencia ~ PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION Spain, [2]Servicio de Cardiología. Hospital de Manises. ~ Manises ~ Spain, [3]Servicio de Celik Sumer*[1], Ahmet Kaya Bilge[2], Murat Inanc[4], Halim Issever[3], Gulfer Cardiología. Hospital Virgen de los Lirios. ~ Alcoi ~ Spain, [4]Servicio de Cardiología. Okumus[1] Hospital Arnau de Vilanova. ~ Valencia ~ Spain [1] Nice Istanbul University Medical Faculty Department of Pulmonary Diseases ~ Istanbul ~ February 27-28 / March 1, 2018 Turkey, [2]Istanbul University Medical Faculty Department of Cardiology ~ Istanbul ~ B46 SAFETY AND EFFICACY OF SUBCUTANEOUS TREPROSTINIL Turkey, [3]Istanbul University Medical Faculty Department of Public Health ~ Istanbul ~ IN CONGENITAL HEART DISEASE- RELATED PULMONARY Turkey, [4]Istanbul University Medical Faculty Department of Rheumatology ~ Istanbul ~ ARTERIAL HYPERTENSION Turkey [1] [1] [2] Nika Skoro-Sajer* , Christian Gerges , Olga Hajnalka Balint , Monika B51 INFLUENCE OF INITIAL RIOCIGUAT MONOTHERAPY AND Kaldararova[3], Iveta Simkova[3], Johannes Jakowitsch[1], Harald Gabriel[1], Helmut Baumgartner[4], Mario Gerges[1], Roela Sadushi-Kolici[1], David TRANSITION FROM SILDENAFIL TO RIOCIGUAT THERAPY Celermajer[5], Irene Lang[1] IN PATIENTS WITH IDIOPATHIC PULMONARY ARTERIAL [1]Cardiology, Medical University of Vienna ~ Vienna ~ Austria, [2]György Gottsegen, HYPERTENSION ON RIGHT HEART REMODELING AND RIGHT Hungarian Institute of Cardiology ~ Budapest ~ Hungary, [3]Department of Cardiology VENTRICULAR – PULMONARY ARTERIAL COUPLING and Angiology, Slovak Medical University and National Institute of Cardiovascular Irina Taran*[1], Anna Belevskaya[4], Marina Saidova[2], Tamila Martynyuk[3], Irina [4] Diseases ~ Bratislava ~ Slovakia, Division of Adult Congenital and Valvular Heart Chazova[5] Disease, Department of Cardiovascular Medicine, University Hospital Muenster, ~ [1] Münster ~ Germany, [5]Sydney Medical School, University of Sydney, ~ Sydney ~ Postgraduate student of Department of Pulmonary Hypertension and Heart Diseases, Australia Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federatio, [2] B47 PARENTERAL USE OF PROSTANOIDS IN PATIENTS WITH Dr. Med. Sci., Prof. Head of Department of Ultrasonic Diagnostic Techniques, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology PULMONARY ARTERIAL HYPERTENSION (PAH) IN A TERTIARY Research and Production Complex of the Ministry of Health of the Russian Federation REFERRAL UNIVERSITY HOSPITAL ~, [3]Dr. Med. Sci., Head of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Eleni Stagaki*, Andriana Papaioannou, Athanasios Pappas, Loukianos [4] Rallidis, Dimitrios Konstantonis, Frantzeska Frantzeskaki, Iraklis Tsagkaris, Research and Production Complex of the Ministry of Health of the Russian Federation, Physician of Ultrasonic Diagnostic Techniques Laboratory, Scientific Research Institute John Lekakis, Spyros Papiris, Apostolos Armaganidis, Stylianos Orfanos, of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Production Anastasia Anthi Complex of the Ministry of Health of the Russian Federation ~ Moscow ~ Russian Fe, [5] Pulmonary Hypertension Clinic, University of Athens, “Attikon” Hospital ~ Athens ~ RAS Academician, Prof., Dr. Med. Sci., Director of Scientific Research Institute of Clinical Greece Cardiology of A. L. Myasnikov, Head of Department of Hypertension, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Res 35 POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B52 THE VALUE OF CARDIOPULMONARY EXERCISE TESTING IN B55 IS REDUCED SYSTEMIC ARTERIAL STIFFNESS A NOVEL ASSESSMENT OF THE SEVERITY OF PULMONARY ARTERIAL SURROGATE INDEX OF SEVERITY IN PATIENTS WITH GROUP 1 HYPERTENSION PATIENTS PULMONARY ARTERIAL HYPERTENSION? Irina Taran*[1], Zarina Valieva[2], Tamila Martynyuk[3], Irina Chazova[4] Helen Triantafyllidi*[1], Olympia Apostolopoulou[2], Benas Dimitris[1], [1] [1] [1] [1]Postgraduate student of Department of Pulmonary Hypertension and Heart Diseases, Leonidas Palaiodimos , Mary Varoudi , George Pavlidis , Anastasia Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Anthi[2], Loukianos Rallidis[1], Orfanos Stylianos[2], Hraklis Tsagkaris[2], Ignatios Research and Production Complex of the Ministry of Health of the Russian Federatio, [2] Ikonomidis[1], Apostolos Armaganidis[2], John Lekakis[1] PhD of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research [1]2nd Department of Cardiology, Medical School, University of Athens, ATTIKON WORLD Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Research and Hospital ~ Athens ~ Greece, [2]2nd Department of Critical Care, Medical School, Production Complex of the Ministry of Health of the Russian Federation ~ Moscow ~ Russ, University of Athens, ATTIKON Hospital ~ Athens ~ Greece SYMPOSIUM [3]Dr. Med. Sci., Head of Department of Pulmonary Hypertension and Heart Diseases, Scientific Research Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology B56 THE ROLE OF SYSTEMIC ENDOTHELIAL GLYCOCALYX ON Research and Production Complex of the Ministry of Health of the Russian Federation, [4] RAS Academician, Prof., Dr. Med. Sci., Director of Scientific Research Institute of Clinical IN PATIENTS WITH GROUP 1 PULMONARY ARTERIAL PULMONARY Cardiology of A. L. Myasnikov, Head of Department of Hypertension, Scientific Research HYPERTENSION HYPERTENSION Institute of Clinical Cardiology of A. L. Myasnikov, Russian Cardiology Res Helen Triantafyllidi*[1], Olympia Apostolopoulou[2], Dimitris Benas[1], Leonidas Palaiodimos[1], Mary Varoudi[1], George Pavlidis[1], Dimitris Kostantonis[2], B53 ENHANCED GLUCOSE METABOLISM IN THE RIGHT Ignatios Ikonomidis[1], Stylianos Orfanos[2], Iraklis Tsagkaris[2], Anastasia VENTRICULAR WALL PREDICTS A PROGNOSTIC IMPACT IN Anthi[2], Apostolos Armaganidis[2], John Lekakis[1] PATIENTS WITH PULMONARY HYPERTENSION [1]2nd Department of Cardiology, Medical School, University of Athens, ATTIKON Nice Nakamura Tomohisa*, Tahara Nobuhiro, Sugiyama Yoichi, Bekki Munehisa, Hospital ~ Athens ~ Greece, [2]2nd Department of Critical Care, Medical School, February 27-28 / March 1, 2018 Tahara Atsuko, Honda Akihiro, Kumagai Eita, Igata Sachiyo, Fukumoto University of Athens, ATTIKON Hospital ~ Athens ~ Greece Yoshihiro Department of Internal Medicine, Division of Cardiovascular Medicine, Kurume B57 RIGHT ATRIUM ENLARGEMENT PREDICTS CLINICALLY University School of Medicine ~ Fukuoka ~ Japan SIGNIFICANT SUPRAVENTRICULAR ARRHYTHMIAS IN PULMONARY ARTERIAL HYPERTENSION. B54 HEMODYNAMIC EFFECTS OF THE ORAL PROSTACYCLIN (IP) Marcin Waligóra*, Anna Tyrka, Jakub Stepniewski, Wojciech Magon, Piotr RECEPTOR AGONIST RALINEPAG IN PULMONARY ARTERIAL Podolec, Grzegorz Kopec HYPERTENSION (PAH) Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College Fernando Torres*[9], Harrison Farber[1], Arsen D Ristic[2], Vallerie Mclaughlin[3], at John Paul II Hospital ~ Krakow ~ Poland John Adams[4], Stewart Turner[4], Preston Klassen[4], Pilar Escribano-Subias[5], Namita Sood[6], Anne M Keogh[7], Lewis Rubin[8] B58 ELECTROCARDIOGRAPHIC CRITERIA OF RIGHT VENTRICULAR [1]Professor of Medicine and Director of the Pulmonary Hypertension Center, Boston HYPERTROPHY REFLECT HEMODYNAMIC IMPROVEMENT IN University School of Medicine ~ Boston, MA ~ United States of America, [2]Professor of PULMONARY HYPERTENSION. Internal Medicine and Cardiology, Belgrade University School of Medicine, Assistant Marcin Waligóra*, Anna Tyrka, Jakub Stepniewski, Piotr Podolec, Grzegorz Director, Department of Cardiology of the Clinical Center of Serbia, Coordinator of the Kopec National Registry on Pulmonary Hypertension ~ Belgrade ~ Serbia, [3]Kim A. Eagle, MD Endowed Professor of Cardiovascular Medicine, Director of Pulmonary Hypertension Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College Program, University of Michigan ~ Ann Arbor, MI ~ United States of America, [4]Arena at John Paul II Hospital ~ Krakow ~ Poland Pharmaceuticals ~ San Diego, CA ~ United States of America, [5]Departamento de Cardiologia, Hospital 12 de Octubre ~ Madrid ~ Spain, [6]University of Texas Health B59 STRUCTURAL AND FUNCTIONAL STATUS OF THE SYSTEMIC Science Center of Houston ~ Houston, TX ~ United States of America, [7]Department of CIRCULATION ARTERIES IN PATIENTS WITH IDIOPATHIC Cardiology, St Vincent’s Hospital ~ Sydney ~ Australia, [8]Emeritus Professor of Medicine, PULMONARY ARTERIAL HYPERTENSION WITH DIFFERENT University of California, San Diego School of Medicine, La Jolla, CA; Adjunct Professor of Medicine, Columbia University College of Physicians and Surgeons ~ New York, FUNCTIONAL ABILITIES AND ENDPOINTS NY ~ United States of America, [9]Medical Director of Lung Transplantation, Head of Iryna Zhyvylo*, Yevhen Titov, Ganna Radchenko, Yurii Sirenko Pulmonary Hypertension Program, UT Southwestern Medical Center, ~ Dallas, TX ~ National Scientific Centre “Institute of Cardiology named after M.D.Strazhesko” of AMS 36 United States of America of Ukraine ~ Kyiv ~ Ukraine POSTER SESSIONS

Wednesday, February 28, 2018 RISK STRATIFICATION AND MEDICAL THERAPY OF PULMONARY ARTERIAL HYPERTENSION

B60 PROGNOSTIC VALUE OF ELECTROCARDIOGRAM IN PATIENTS WITH IDIOPATHIC/HEREDITARY PULMONARY ARTERIAL HYPERTENSION Elisa Zuffa*, Fabio Dardi, Nikita Tanese, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Enrico Monti, Alessandra Albini, Daniele Guarino, Filippo Pasca, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno Galiè University of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy WORLD SYMPOSIUM ON RIGHT VENTRICULAR ASSISTANCE AND LUNG TRANSPLANTATION PULMONARY B61 PERCUTANEOUS ATRIAL SEPTOSTOMY WITH PERIPHERAL HYPERTENSION STENT IN A PATIENT WITH SYNCOPE AND REFRACTORY PULMONARY ARTERIAL HYPERTENSION AND MILD HYPOXIA Vasil Velchev* St. Anna Hospital ~ Sofia ~ Bulgaria Nice February 27-28 / March 1, 2018

TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSION

B62 POTENCY, SELECTIVITY, AND COMPARATIVE PLATELET AND B63 SILDENAFIL ADDED TO PIRFENIDONE IN PATIENTS WITH VASCULAR ACTIVITY OF RALINEPAG ACTING ON IP RECEPTORS ADVANCED IDIOPATHIC PULMONARY FIBROSIS (IPF) AND IN HUMAN TISSUES PULMONARY HYPERTENSION (PH): A PHASE IIB, RANDOMIZED, John Adams*[3], Brendan Whittle[1], Lei Shen[2], Jigisha Patel[2], Lucie H DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY Clapp[2] Jürgen Behr*[1], Steven D Nathan[2], Sergio Harari[3], Wim Wuyts[4], Klaus-Uwe [1]William Harvey Research Institute, Barts and the London School of Medicine, Queen Kirchgaessler[5], Monica Bengus[5], Frank Gilberg[5], Athol U Wells[6] [2] Mary University of London ~ London ~ United Kingdom, Institute of Cardiovascular [1]Department of Internal Medicine V, LMU and Asklepios Fachkliniken Gauting, [3] Science, University College London ~ London ~ United Kingdom, Arena Comprehensive Pneumology Center ~ Munich ~ Germany, [2]INOVA Heart and Pharmaceuticals ~ San Diego, CA ~ United States of America Vascular Institute, Inova Fairfax Hospital ~ Vienna, VA ~ United States of America, [3] U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, MultiMedica IRCCS ~ Milan ~ Italy, [4]Department of Pulmonary Medicine, Unit for Interstitial Lung Diseases, University of Leuven ~ Leuven ~ Belgium, [5]F Hoffmann-La Roche, Ltd. ~ Basel ~ Switzerland, [6]Interstitial Lung Disease Unit, Royal Brompton Hospital ~ London ~ United Kingdom

37 POSTER SESSIONS

Wednesday, February 28, 2018 TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSION

B64 INDIVIDUALIZED HOME-BASED EXERCISE PROGRAM FOR THE B68 ERS TASK FORCE: EXERCISE TRAINING AND REHABILITATION IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION PATIENTS: IN PATIENTS WITH SEVERE CHRONIC PULMONARY MULTIPLE CASE STUDY HYPERTENSION Lina Butane*, Daina Šmite, Andris Skride Ekkehard Grünig*[1], Christina Eichstaedt[1], Joan-Albert Barberà[2], Isabel [2] [3] [3] [4] Latvian ~ Riga ~ Latvia Blanco , Eduardo Bossone , Antonio Cittadini , Marion Delcroix , Sean Gaine[5], Stefano Ghio[6], Lina Gumbiene[7], Frances Handoko De Man[8], B65 UDENAFIL FOR THE TREATMENT OF PULMONARY ARTERIAL Martin Johnson[9], David Kiely[11], Gabor Kovacs[12], Alison Mackenzie[9], HYPERTENSION Robert Naeije[10], Silvia Ulrich[13], Horst Olschewski[12], Abílio Reis[14], Mário [14] [8] [9] Hyuk Jae Chang*[1], Shin-Jeong Song[1], Sung-A Chang[2], Hyung Kwan Kim[3], Santos , Anton Vonk Noordegraaf , Andrew Peacock Duk-Kyung Kim[2] [1]Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg WORLD ~ Heidelberg ~ Germany, [2]2. Hospital Clinic at the University of Barcelona ~ Barcelona [1]Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health ~ Spain, [3]Department of Cardiac Surgery, University Hospital Salerno ~ Salerno ~ System, Seoul ~ Seoul ~ Korea, Republic of, [2]Division of Cardiology, Department of SYMPOSIUM Italy, [4]Department of Pneumology, University Hospital Leuven ~ Leuven ~ Belgium, Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan ON [5]Department of Pulmonology, Mater Misericordiae University Hospital ~ Dublin University School of Medicine ~ Seoul ~ Korea, Republic of, [3]Department of ~ Ireland, [6]Division of Cardiology, Università degli studi di Pavia ~ Pavia ~ Italy, [7] Cardiology, Seoul National University Hospital, Seoul, South Korea ~ Seoul ~ Korea, PULMONARY Department of Cardiovascular Medicine, Vilnius University Hospital Santaros Klinikos Republic of ~ Vilnius ~ Lithuania, [8]Department of Pulmonology, VU University Medical Center HYPERTENSION Amsterdam ~ Amsterdam ~ Netherlands, [9]Golden Jubilee Hospital ~ Glasgow ~ B66 ACUTE HEMODYNAMIC CHANGES AFTER SINGLE United Kingdom, [10]Department of Cardiology, University Clinic Brussels - Erasme ADMINISTRATION OF UDENAFIL IN PULMONARY ARTERIAL Hospital ~ Brussels ~ Belgium, [11]Department of Respiratory Medicine, Royal HYPERTENSION (PHASE IIA STUDY) Hallamshire Hospital ~ Sheffield ~ United Kingdom,[12] Department Internal Medicine, [13] [3] [1] [2] [3] Medical University of Graz ~ Graz ~ Austria, Centre for Pulmonary Hypertension, Nice Sung-A Chang* , Hyung-Kwan Kim , Hyuk Jae Chang , Duk-Kyung Kim [14] February 27-28 / March 1, 2018 University Hospital Zurich ~ Zurich ~ Switzerland, 14. Department of Internal [1]Seoul National University Hospital ~ Seoul ~ Korea, Republic of, [2]Yonsei Severance Medicine, Hospital Geral de Santo António ~ Porto ~ Portugal, [15]Cardiology and Hospital ~ Seoul ~ Korea, Republic of, [3]Division of Cardiology, Department of Pneumology ~ Europe ~ United Kingdom Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine ~ Seoul ~ Korea, Republic of B69 ADVANCED CORRECTIVE TREATMENT USING PULMONARY VASOREACTIVITY TESTING IN PATIENTS WITH EISENMENGER B67 BASELINE AND DEMOGRAPHIC DATA ON THE FIRST 150 SYNDROME WITH CONGENITAL HEART DISEASES; PATIENTS FROM SPHERE (UPTRAVI® [SELEXIPAG]: THE USERS RETROSPECTIVE STUDY IN SINGLE CENTER DRUG REGISTRY) Jo Won Jung*, Se Yong Jung, Jae Young Choi, Yu Lim Shin, Han Ki Park, Kelly Chin*[1], Kristin Highland[2], Nick H Kim[3], Murali Chakinala[4], Anna Young Hwan Park Hemnes[5], Harrison Farber[6], Carol Zhao[7], Mike Keating[8], Brian Hartline[7], Johanna Colvin[7], Vallerie Mclaughlin[9] Yonsei University College of Medicine ~ Seoul ~ Korea, Republic of [1] Pulmonary and Critical Care Division, University of Texas Southwestern Medical Center B70 CONTINUOUS S.C. DIURETIC THERAPY AT HOME IMPROVES ~ Dallas ~ United States of America, [2]Cleveland Clinic ~ Cleveland ~ United States of America, [3]Division of Pulmonary and Critical Care Medicine, University of California QUALITY OF LIFE IN END-STAGE PAH San Diego ~ La Jolla ~ United States of America, [4]Washington University School of Miriam Kap* [5] Medicine ~ St. Louis ~ United States of America, Vanderbilt University Medical Center Erasmus MC ~ Rotterdam ~ Netherlands ~ Nashville ~ United States of America, [6]Boston University School of Medicine ~ Boston [7] ~ United States of America, Actelion Pharmaceuticals US ~ South San Francisco B71 BENEFICIAL EFFECTS OF FERRIC CARBOXYMALTOSE IN ~ United States of America, [8]Actelion Pharmaceuticals US ~ South San Francisco ~ United States of America, [9]University of Michigan Medical Center ~ Ann Harbor ~ PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION AND United States of America IRON DEFICIENCY: A LONG-TERM PILOT STUDY Tilmann Kramer*, Kristiana Natsina, Thomas Viethen, Felix Gerhardt, Daniel Dumitrescu, Stephan Baldus, Stephan Rosenkranz Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Germany ~ Köln ~ Germany 38 POSTER SESSIONS

Wednesday, February 28, 2018 TRIALS DESIGN AND NEW THERAPIES FOR PULMONARY ARTERIAL HYPERTENSION

B72 IDENTIFICATION OF CELASTRAMYCIN AS A NOVEL B76 IDENTIFICATION OF EMETINE AS A NOVEL THERAPEUTIC THERAPEUTIC AGENT FOR PULMONARY ARTERIAL AGENT FOR PULMONARY HYPERTENSION IN RATS -HIGH- HYPERTENSION THROUGHPUT SCREENING OF 5,562 COMPOUNDS- Ryo Kurosawa*, Satoh Kimio, Nobuhiro Kikuchi, Taijyu Satoh, Junichi Omura, Mohammad Abdul Hai Siddique*, Kimio Satoh, Ryo Kurosawa, Md Elias Masamichi Nogi, Shinichiro Sunamura, Tomohiro Otshuki, Nobuhiro Yaoita, Al- Mamun, Nobuhiro Kikuchi, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Mohammad Abdul Hai Siddique, Md Elias Al-Mamun, Toru Shimizu, Hiroaki Shinichiro Sunamura, Hiroaki Shimokawa Shimokawa Department of Cardiovascular Medicine ~ Sendai ~ Japan Tohoku University ~ Sendai ~ Japan B77 PYRIDOXAMINE ATTENUATED THE SMOOTH MUSCLE CELL B73 CHRONIC TRANSFUSION EXCHANGES IN THE MANAGEMENT PROLIFERATION AND HEMODYNAMIC AGGRAVATION IN THE OF SICKLE CELL DISEASE-ASSOCIATED PRECAPILLARY PULMONARY ARTERY HYPERTENSION ANIMAL MODEL WORLD PULMONARY HYPERTENSION: A PILOT STUDY Kuk Hui Son*[1], Seyeon Oh[1], Seungbum Choi[1], Kyung-Hee Kim[2], Minsu SYMPOSIUM Turpin Matthieu*, Parent Florence, Jais Xavier, Montani David, Sitbon Olivier, Kim[1], Hanul Choi[1], Jeongwon Ryu[3], Kyunghee Byun[1], Wook-Jin Chung[1] ON Humbert Marc, Simonneau Gerald, Savale Laurent [1]Gachon Cardiovascular Research Institute, Gachon University ~ Incheon ~ Korea, Service de pneumologie - CHU Bicêtre ~ Le Kremlin Bicêtre ~ France Republic of, [2]Departement of Cardiology, Sejong General Hospital ~ Bucheon ~ Korea, PULMONARY Republic of, [3]Advanced Medical Technology Laboratory Healcerion Co., Ltd ~ Seoul ~ B74 SAFETY AND EFFICACY OF IMMUNOADSORPTION AS AN Korea, Republic of HYPERTENSION ADD-ON TO MEDICAL TREATMENT IN PATIENTS WITH SEVERE B78 THE MOTION STUDY: A RESPONDER ANALYSIS OF RIOCIGUAT IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION (IPAH) [1] [2] [3] [3] [2] [1] [3] [4] Namita Sood* , Alvaro Aranda , David Platt , Larose Anneliese , Frank Christian Nagel* , Benjamin Egenlauf , Ralf Ewert , Hans Lehmkuhl , [4] [3] [5] [1] [6] [7] Kleinjung , Gerald O’brien Nice Stephan Rosenkranz , Nicola Benjamin , Vedat Schwenger , Felix Herth , [1] [2] February 27-28 / March 1, 2018 Ekkehard Grünig[1] The Ohio State University ~ Colombus ~ United States of America, CardioPulmonary Research Center ~ San Juan ~ Puerto Rico, [3]Bayer Pharmaceuticals, Inc. ~ Whippany ~ [1] Centre for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg United States of America, [4]Bayer Pharmaceuticals, Inc. ~ Berlin ~ Germany ~ Heidelberg ~ Germany, [2]Lung Centre, Klinikum Mittelbaden ~ Baden-Baden ~ Germany, [3]Clinic for Internal Medicine, Greifswald University Hospital ~ Greifswald ~ Germany, [4]Medical Practice for Cardiology, Augustenburger Platz 1 ~ Berlin ~ Germany, [5]Department of Cardiology, Heart Center at the University Hospital Cologne and Cologne Cardiovascular Research Center ~ Cologne ~ Germany, [6]Department of Nephrology, Klinikum Stuttgart ~ Stuttgart ~ Germany, [7]Department of Internal Medicine, Pulmonology and Critical Care Medicine, Thorax Clinic at the University Hospital Heidelberg ~ Heidelberg ~ Germany B75 PRECLINICAL AND PHASE 1 CLINICAL CHARACTERIZATION OF LIQ861, A NEW DRY POWDER FORMULATION OF TREPROSTINIL Mike Royal*[1], Robert Roscigno[1], Toby Vaughn[1], Stephanie Anderson[1], William Wargin[2], Rex Williams[1], Clint Forsythe[3], Thomas Hunt[3], Patrick Normand[5], Manal Hantash[5], John Dillberger[4] [1]Liquidia Technologies ~ RTP ~ United States of America, [2]Nuventra, Inc. ~ Durham, NC ~ United States of America, [3]PPD Development, LLC ~ Austin, TX ~ United States of America, [4]J. Dillberger LLC ~ Nashville, IN ~ United States of America, [5]ITR Laboratories ~ Montreal, Quebec ~ Canada

39 POSTER SESSIONS

Wednesday, February 28, 2018 PH DUE TO LEFT HEART DISEASES

B79 HEMODYNAMIC PREDICTORS OF ACUTE RIGHT HEART FAILURE B84 PATHOPHYSIOLOGY OF PULMONARY HYPERTENSION DUE TO AFTER HEART TRANSPLANTATION (HT). EMERGING ROLE OF LEFT HEART DISEASE – A HEMODYNAMIC STUDY PULMONARY ARTERY COMPLIANCE (PAC) Christian Gerges*[1], Mario Gerges[1], Pierre Fesler[2], Anna-Maria Pistritto[3], Oscar Aguirre-Zurita*, David Galvez, Walter Alarco, Oscar Guerrero, Miguel David Celermajer[4], Irene Lang[1] Lescano, Christian Soplopuco, Ruth Villarroel, Ana Sihuayro [1]Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, [2] INCOR ~ LIMA ~ Peru Medical University of Vienna ~ Vienna ~ Austria, PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, and Department of Internal Medicine, Lapeyronie B80 PDE-5 INHIBITORS FOR PULMONARY HYPERTENSION DUE TO Hospital ~ Montpellier ~ France, [3]Division of Cardiology, Ferrarotto Hospital, University of Catania ~ Catania ~ Italy, [4]Department of Cardiology, Sydney Medical School, LEFT HEART DISEASE: POTENTIAL BENEFIT? University of Sydney ~ Sydney ~ Australia WORLD Hayley Barnes*[1], Zoe Brown[2], Andrew Burns[3], Trevor Williams[1] [1]Alfred Hospital ~ Melbourne ~ Australia, [2]Royal Adelaide Hospital ~ Adelaide ~ B85 EFFECTS OF CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST SYMPOSIUM Australia, [3]Department of Cardiology, St Vincent’s Hospital ~ Melbourne ~ Australia DEVICE IMPLANTATION ON PULMONARY HAEMODYNAMICS ON IN ADVANCED HEART FAILURE PATIENTS B81 CLINICAL PHENOTYPES, VENTILATORY RESPONSES TO PULMONARY Ada Francesca Giglio*[1], Luciana D’’Angelo[1], Enrico Perna[1], Enrico EXERCISE AND OUTCOMES OF PULMONARY HYPERTENSION Ammirati[1], Francesca Macera[1], Manlio Gianni Cipriani[1], Fabrizio Oliva[2], HYPERTENSION DUE TO LEFT HEART DISEASE: ROLE OF THE PRE-CAPILLARY Andrea Garascia[1], Claudio Russo[2], Maria Frigerio[1] COMPONENT [1]2nd Section of Cardiology-Heart Failure and Transplantation, De Gasperis Sergio Caravita*[3], Andrea Faini[1], Sandy Carolino D’Araujo[2], Céline CardioCenter, Niguarda Hospital, Milan, Italy. ~ Milano ~ Italy, [2]De Gasperis Cardio Dewachter[2], Laura Chomette[2], Antoine Bondue[2], Robert Naeije[2], Center, ASST Grande Ospedale Metropolitano Niguarda Ca’ Granda, Milan, Italy ~ [1] [2] Milano ~ Italy Nice Gianfranco Parati , Jean-Luc Vachiéry February 27-28 / March 1, 2018 [1]Dept of Cardiovascular, Neural, and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano ~ Milano ~ Italy, [2]Dept of Cardiology, Cliniques B86 GENETIC ANALYSIS AND CHAMBER SPECIFIC GENE Universitaires de Bruxelles, Hôpital Académique Erasme ~ Bruxelles ~ Belgium, [3]Dept EXPRESSION ANALYSIS IN PATIENTS WITH CPC-PH AND IPC-PH of Cardiovascular, Neural, and Metabolic Sciences, San Luca Hospital IRCCS Istituto Hidetaka Kioka*, Yoshihiro Asano, Ayako Takuwa, Yohei Miyashita, Hiroshi Auxologico Italiano; Dept of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Miyawaki, Tomohito Ohtani, Yoshiki Sawa, Keiko Yamauchi-Takihara, Yasushi Académique Erasme ~ Milano ~ Italy Sakata B82 DYSREGULATION OF WNT-RELATED SIGNALING PATHWAY Osaka University Graduate School of Medicine ~ Suita ~ Japan CORRELATES WITH THE DEVELOPMENT OF PH SECONDARY TO B87 THERAPEUTIC POTENTIAL OF PHOSPHODIESTERASE TYPE 5 LEFT VENTRICULAR DYSFUNCTION INHIBITORS IN HEART FAILURE WITH PRESERVED EJECTION Zen-Kong Dai*, I-Chen Chen, Jong-Hau Hsu FRACTION AND COMBINED POST- AND PRE-CAPILLARY Dept. of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical PULMONARY HYPERTENSION University ~ Kaohsiung ~ Taiwan Tilmann Kramer*[2], Kristina Orlova[2], Felix Gerhardt[2], Daniel Dumitrescu[2], B83 A NEW SCORE TO DIFFERENTIATE IDIOPATHIC PULMONARY Henrik Ten Freyhaus[2], Martin Hellmich[1], Stephan Baldus[2], Stephan [2] ARTERIAL HYPERTENSION FROM PULMONARY HYPERTENSION Rosenkranz DUE TO HEART FAILURE WITH PRESERVED EJECTION [1]Institut für Medizinische Statistik, Informatik und Epidemiologie (IMSIE), Universität zu Köln, Germany ~ Köln ~ Germany, [2]Klinik III für Innere Medizin, Herzzentrum der FRACTION Universität zu Köln, Germany ~ Köln ~ Germany Fabio Dardi*[1], Nikita Tanese[1], Sergio Caravita[2], Andrea Rinaldi[1], Celine Dewachter[3], Enrico Gotti[1], Thomas Nguyen[3], Enrico Monti[1], Alessandra B88 PRESENCE OF PULMONARY HYPERTENSION IS A POOR Albini[1], Massimiliano Palazzini[1], Alessandra Manes[1], Jean Luc Vachiery[3], PROGNOSTIC FACTOR IN PATIENTS WITH PRIMARY MITRAL Nazzareno Galiè[1] REGURGITATION NOT IN SECONDARY MITRAL REGURGITATION [1]University of Bologna, Department of Specialized Diagnostic and Experimental [1] [2] [2] [2] [2] Ju-Hee Lee* , Jae-Hyeong Park , Hee-Jin Kwon , Seok-Woo Seong , Jin Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy, IRCCS Ospedale S. Luca ~ Milano ~ Kyung Ohh[2], Myeong-Chan Cho[2] Italy, [3]Pulmonary Hypertension and Heart Failure Clinic - CUB Hop Erasme ~ Brussels ~ [1] [2] Belgium Chungbuk National University Hospital ~ Cheongju ~ Korea, Republic of, Chungnam 40 National University ~ Daejeon ~ Korea, Republic of POSTER SESSIONS

Wednesday, February 28, 2018 PH DUE TO LEFT HEART DISEASES

B89 FLUID CHALLENGE DURING RIGHT HEART CATHETERIZATION: B94 MEAN VELOCITY OF THE PULMONARY ARTERY AS AN EARLY AN EXPERIENCE FROM A TERTIARY PULMONARY PROGNOSTIC INDICATOR IN HFREF IN RELATION WITH HYPERTENSION REFERRAL CENTRE FIBROSIS BIOMARKERS GALECTIN-3 AND ST2/IL-1. Nima Moghaddam*[1], John Swiston[1], Robert D Levy[1], Lisa Lee[2], Victor F Blanca Trejo-Velasco*[1], Oscar Fabregat-Andrés[1], Maria Pilar García- Huckell[1], Nathan W Brunner[1] González[2], Monica Ferrando[1], Diana Perdomo-Londoño[1], Joaquina [1] [1] [1] [1]University of British Columbia ~ Vancouver ~ Canada, [2]Vancouver Coastal Health ~ Belchi , Cristina Albiach-Montañana , Sergio Sánchez-Álvarez , Juan Pablo Vancouver ~ Canada Cardenas-Tealdo[1], Salvador Morell-Cabedo[1], Francisco Ridocci-Soriano[1] [1]Hospital General Universitario de Valencia ~ Valencia ~ Spain, [2]Centro Médico Eresa B90 EFFECT OF IMPROVEMENT OF PULMONARY HYPERTENSION Valencia ~ Valencia ~ Spain AND/OR LEFT VENTRICULAR SYSTOLIC FUNCTION ON THE LONG-TERM PROGNOSIS OF PATIENTS WITH PULMONARY B95 A RARE AND RAPIDLY PROGRESSING CASE OF PULMONARY WORLD HYPERTENSION WITH LEFT VENTRICULAR SYSTOLIC HYPERTENSION SYMPOSIUM DYSFUNCTION Yalin Tolga Yaylali*, Sonmez Gokhan ON Jae-Hyeong Park*[3], Ju-Hee Lee[1], Hee-Jin Kwon[2] Pamukkale University ~ Denizli ~ Turkey [1]Chungbuk National University Hospital ~ Cheongju ~ Korea, Republic of, [2]Chungnam PULMONARY National University ~ Daejeon ~ Korea, Republic of, [3]~ Korea, Republic of HYPERTENSION B91 COMPARATIVE OUTCOME OF INCIDENT PATIENTS WITH PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE ACCORDING WITH THE HAEMODYNAMIC CLASSIFICATION OF Nice THE 2015 ESC-ERS PULMONARY HYPERTENSION GUIDELINES February 27-28 / March 1, 2018 Filippo Pasca*, Fabio Dardi, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Alessandra Albini, Enrico Monti, Elisa Zuffa, Daniele Guarino, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Nazzareno Galiè University of Bologna, Department of Specialized, Diagnosticand Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy B92 NEDA PH-LHD PREDICTIVE MODEL: VALIDATION OF DIASTOLIC MARKERS OF PULMONARY HYPERTENSION WITH RIGHT HEART CATHETERISATION Geoff Strange*[1], David Playford[1], Pyi Naing[1], Jim Codde[1], David Celermajer[2], Gregory Scalia[3], Kevin Chung[1] [1]The University of Notre Dame ~ Fremantle ~ Australia, [2]The University of Sydney ~ Sydney ~ Australia, [3]The University of Queensland ~ Brisbane ~ Australia B93 RHO-KINASE AND CYCLOPHILIN A AS NOVEL THERAPEUTIC TARGETS FOR CARDIAC DIASTOLIC DYSFUNCTION AND POST- CAPILLARY PULMONARY HYPERTENSION Shinichiro Sunamura*, Kimio Satoh, Ryo Kurosawa, Tomohiro Ohtsuki, Nobuhiro Kikuchi, Mohammad Elias-Al-Mamun, Toru Shimizu, Shohei Ikeda, Kota Suzuki, Taijyu Satoh, Junichi Omura, Masamichi Nogi, Mohammad Abdul Hai Siddique, Satoshi Miyata, Hiroaki Shimokawa Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine ~ Sendai ~ Japan 41 POSTER SESSIONS

Thursday, March 1, 2018 PH DUE TO CHRONIC LUNG DISEASES

C10 A POTENTIAL ROLE FOR PDE-5 INHIBITORS FOR PULMONARY C13 INHALED ILOPROST AS POTENTIAL NEW TREATMENT FOR HYPERTENSION DUE TO LUNG DISEASE/HYPOXIA GROUP 3 PULMONARY HYPERTENSION Hayley Barnes*[1], Zoe Brown[2], Andrew Burns[3], Trevor Williams[1] Chih-Hsin Hsu*, Po-Lan Su [1]Alfred Hospital ~ Melbourne ~ Australia, [2]Royal Adelaide Hospital ~ Adelaide ~ Department of Internal Medicine, National Cheng Kung University Hospital ~ Tainan ~ Australia, [3]Department of Cardiology, St Vincent’s Hospital ~ Melbourne ~ Australia Taiwan C11 SEVERE PULMONARY HYPERTENSION IN TOBACCO-INDUCED C14 PROGNOSTIC FACTORS OF PULMONARY HYPERTENSION WITH RESPIRATORY DISEASES SEVERE LUNG DISEASE IN RETROSPECTIVE STUDY Samy Chelabi*[1], Guillaume Chassagnon[2], Laurent Savale[1], Jason Nakayama Kazuhiko*, Emoto Noriaki, Tamada Naoki, Shinkura Yuto, Onishi Weatherald[5], Xavier Jais[1], Athenais Boucly[1], Herve Mal[4], Pierre-Regis Hiroyuki, Yanaka Kenichi, Matsuoka Yoichiro, Shinke Toshiro, Hirata Ken-Ichi [3] [1] [1] [1] WORLD Burgel , Gerald Simonneau , Olivier Sitbon , Marc Humbert , David Kobe University Graduate School of Medicine ~ Kobe ~ Japan Montani[1] SYMPOSIUM [1]APHP, Service de pneumologie, Hôpital Bicêtre ~ Le Kremlin-Bicêtre ~ France, [2]APHP, C15 ESTABLISHMENT OF A NOVEL MODEL OF GROUP 3 ON Service de radiologie, Hôpital Cochin ~ Paris ~ France, [3]APHP, Service de pneumologie, PULMONARY HYPERTENSION INDUCED BY SU5416/HYPOXIA Hôpital Cochin ~ Paris ~ France, [4]APHP, Service de pneumologie, Hôpital Bichat ~ Paris IN RATS PULMONARY ~ France, [5]Department of Medecine, University of Calgary ~ Calgary ~ Canada Yosuke Wada*, Kitaguchi Yoshiaki, Yasuo Masanori, Hanaoka Masayuki HYPERTENSION C12 COMPARATIVE OUTCOME OF INCIDENT PATIENTS WITH First Department of Internal Medicine, Shinshu University School of Medicine ~ PULMONARY HYPERTENSION DUE TO LUNG DISEASE Matsumoto ~ Japan ACCORDING WITH THE HAEMODYNAMIC CLASSIFICATION OF C16 A RARE RESPIRATORY CONDITION ASSOCIATED WITH THE 2015 ESC-ERS PULMONARY HYPERTENSION GUIDELINES Nice PULMONARY HYPERTENSION Daniele Guarino*, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, February 27-28 / March 1, 2018 Yalin Tolga Yaylali*, Sinan Durmus, Alperen Emre Akgun, Fatma Evyapan Fabio Dardi, Alessandra Albini, Enrico Monti, Elisa Zuffa, Filippo Pasca, Nikita Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Pamukkale University ~ Denizli ~ Turkey Nazzareno Galiè University of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy

CTEPH

C17 BALLOON PULMONARY ANGIOPLASTY(BPA) AS AN C18 SUBMASSIVE PULMONARY EMBOLISM TREATMENT WITH ADDITIONAL TREATMENT OPTION FOR PATIENTS WITH ULTRASOUND-ACCELERATED THROMBOLYSIS (SPEAR) TRIAL: A INOPERABLE CHRONIC THROMBOEMBOLIC PULMONARY PROSPECTIVE STUDY. HYPERTENSION (CTEPH) TREATED WITH RIOCIGUAT. Wael Berjaoui*, Michael Knox, Reda Girgis, David Langholz Shiro Adachi*[1], Nakano Yoshihisa[1], Tajima Fumitaka[2], Shimokata Spectrum Health ~ Grand Rapids ~ United States of America Shigetake[1], Kamimura Yoshihiro[1], Okumura Naoki[1], Murohara Toyoaki[1], Kondo Takahisa[1] C19 PREVALENCE AND LONG TERM OUTCOME OF CTEPH - SINGLE [1]Nagoya university graduate school of medicine ~ nagoya ~ Japan, [2]Nagoya university CENTRE EXPERIENCE. hospital ~ Nagoya ~ Japan Marcela Bohacekova*, Tatiana Valkovicova, Monika Kaldararova, Iveta Simkova Department of Cardiology and Angiology, Medical Faculty, Slovak Medical University and National Institute of Cardiovascular Diseases, ~ Bratislava ~ Slovakia 42 POSTER SESSIONS

Thursday, March 1, 2018 CTEPH

C20 IS SUBDURAL HAEMORRHAGE AFTER PULMONARY C24 EXPERIENCE OF ONE YEAR OF BALLOON PULMONARY ENDARTERECTOMY UNDER-ESTIMATED? ANGIOPLASTY IN A SINGLE CENTER: SAFETY AND SHORT TERM Alicia Xue Fen Chia*[1], Jonathan Yap[1], Wen Ruan[1], Kenny Wei-Tsen Loh[2], RESULTS Foong Koon Cheah[2], Ai Leen Ang[2], Ghee Chee Phua[2], Duu Wen Sewa[2], Enrico Gotti*, Massimiliano Palazzini, Andrea Rinaldi, Fabio Dardi, Enrico Ju Le Tan[1], David Jenkins[3], Victor Tar Toong Chao[1], Soo Teik Lim[1] Monti, Alessandra Albini, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Nikita [1]National Heart Centre Singapore ~ Singapore ~ Singapore, [2]Singapore General Tanese, Mariangela Rotunno, Antonio Colangelo, Alessandra Manes, Hospital ~ Singapore ~ Singapore, [3]Papworth Hospital ~ Cambridge ~ United Nazzareno Galiè Kingdom University of Bologna, Department of Specialized Diagnostic and Experimental Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy C21 ABSENCE OF THE FACTOR V LEIDEN MUTATION AND GENETIC RISK FOR CHRONIC THROMBOEMBOLIC PULMONARY C25 EXERCISE RIGHT HEART CATHETERIZATION IN PATIENTS WITH WORLD HYPERTENSION CHRONIC THROMBOEMBOLIC DISEASE – THERE IS A NEED FOR Mark Dodson*[2], Kelli Sumner[1], Jadyn Sanders[1], Lynette Brown[2], Scott DEFINITION OF EXERCISE PULMONARY HYPERTENSION SYMPOSIUM [2] [2] [1] [2] Stevens , Scott Woller , Hunter Best , Gregory Elliott Stefan Guth*[1], Christoph Wiedenroth[1], Rieth Andreas[1], Christoph ON [1]ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories ~ Salt Lake Liebetrau[1], Manuel Richter[2], Hossein Ardeschir Ghofrani[1], Eckhard Mayer[1] [2] PULMONARY City, UT ~ United States of America, Department of Medicine, Intermountain Medical [1]Kerckhoff-Clinic ~ Bad Nauheim ~ Germany, [2]University Clinic Giessen ~ Giessen ~ Center ~ Murray, UT ~ United States of America Germany HYPERTENSION C22 EFFECT OF BALLOON PULMONARY ANGIOPLASTY ON RIGHT C26 END-STAGE CHRONIC THROMBOEMBOLIC PULMONARY VENTRICULAR AFTERLOAD IN CHRONIC THROMBOEMBOLIC HYPERTENSION: UNIQUE MOLECULAR AND PULMONARY HYPERTENSION HISTOPATHOLOGICAL IMPRINT [1] [1] [1] Nice Christian Gerges* , Mario Gerges , Nika Skoro-Sajer , Roela Sadushi- [1] [2] [3] [1] February 27-28 / March 1, 2018 [1] [2] [2] [2] Dijana Iloska* , Jochen Wilhelm , Stefan Guth , Rajkumar Savai , Ralph Kolici , Bernhard Moser , Shahrokh Taghavi , Walter Klepetko , Hiromi [2] [2] [1] [3] [3] [1] Schermuly , Ludger Fink , Werner Seeger , Eckhard Mayer , Soni Matsubara , Irene Lang Pullamsetti Savai[1] [1] Department of Internal Medicine II, Division of Cardiology, Medical University of [1] [2] [2] Max-Planck-Institute for Heart and Lung Research ~ Bad Nauheim ~ Germany, Vienna, General Hospital ~ Vienna ~ Austria, Department of Surgery, Division of Department of Internal Medicine, Universities of Giessen and Marburg Lung Center ~ Thoracic Surgery, Medical University of Vienna, Vienna General Hospital ~ Vienna ~ Giessen ~ Germany, [3]Kerckhoff-Klinik ~ Bad Nauheim ~ Germany Austria, [3]Department of Cardiology, Okayama Medical Center ~ Okayama ~ Japan C27 USEFULNESS OF PERCUTANEOUS TRANSLUMINAL C23 VENTILATION/PERFUSION SCINTIGRAPHY FOR THE DIAGNOSIS PULMONARY ANGIOPLASTY FOR CHRONIC PULMONARY OF CTEPH AFTER SPLENECTOMY [4] [4] [1] THROMBOEMBOLIC DISEASE Mario Gerges* , Christian Gerges , Karanikas Georgios , Wolfgang [1] [2] [1] [1] [2] [2] [3] [3] Takumi Inami* , Masaharu Kataoka , Yohei Shigeta , Kaori Takeuchi , Birkfellner , Isolde Maria Weinberg , Ilse Schwarzinger , Max Publig , Nika [1] [1] [1] [1] [4] [4] [2] [4] Hanako Kikuchi , Ayumi Goda , Haruhisa Ishiguro , Hideaki Yoshino , Toru Skoro-Sajer , Maria Frey , Michael Schaffarich , Johannes Jakowitsch , [1] Klaus Lechner[5], Bernhard Moser[6], Taghavi Sharokh[6], Walter Klepetko[6], Satoh [1] [2] Marcus Hacker[1], Irene Marthe Lang[4] Kyorin University School of Medicine ~ Tokyo ~ Japan, Keio University School of Medicine ~ Tokyo ~ Japan [1]Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ C28 THE RELATIONSHIP BETWEEN THE DIAMETER OF BRONCHIAL Vienna ~ Austria, [2]Center for Medical Physics and Biomedical Engineering, Vienna General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, ARTERIES AND THE RISK OF PULMONARY EDEMA OR AIRWAY [3]Department of Laboratory Medicine, Division of Medical-Chemical Laboratory BLEEDING FOR PULMONARY ENDARTERECTOMY Diagnostics, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ [4] Takayuki Jujo*, Tanabe Nobuhiro, Sakao Seiichiro, Akira Naito, Suda Rika, Vienna ~ Austria, Department of Internal Medicine II, Division of Cardiology, General Kasai Hajime, Nishimura Rintaro, Sugiura Toshihiko, Ishida Keiichi, Tatsumi Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [5] Department of Internal Medicine I, Division of Haematology, General Hospital Vienna Koichiro (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria, [6]Department of Surgery, Graduated School of Medicine, Chiba University ~ Chiba ~ Japan Division of Thoracic Surgery, General Hospital Vienna (AKH-Wien), Medical University of Vienna ~ Vienna ~ Austria 43 POSTER SESSIONS

Thursday, March 1, 2018 CTEPH

C29 HOW DIFFERENT IS CENTRAL VERSUS PERIPHERAL CTEPH? C35 DRUG-DRUG INTERACTION EVALUATION BETWEEN DIRECT Monika Kaldararova*[1], Marcela Bohacekova[1], Jozef Pacak[1], Tatiana ORAL ANTICOAGULANTS AND PHOSPHODIESTERASE-5 Valkovicova[1], Anna Remkova[2], Pavel Jansa[3], Jaroslav Lindner[4], Iveta INHIBITORS: A POTENTIAL RISK FOR PULMONARY Simkova[1] HYPERTENSION PATIENTS? [1]Department of Cardiology and Angiology, Slovak Medical University and National Victor Margelidon-Cozzolino*[1], Sophie Hodin[2], Xavier Delavenne[2], [2] Institute of Cardiovascular Diseases ~ Bratislava ~ Slovakia, Department of Internal Laurent Bertoletti[3] Medicine, Slovak Medical University ~ Bratislava ~ Slovakia, [3]Center for Pulmonary [1]INSERM U1059, laboratoire SAINBIOSE ~ Saint-Priest-en-Jarez ~ France, [2]Faculté de Hypertension, General Teaching Hospital and Ist Faculty of Medicine of Charles [3] University ~ Prague ~ Czech Republic, [4]2nd Surgical Department-Department of Médecine de Saint-Etienne ~ Saint-Etienne ~ France, Centre Hospitalier Universitaire Cardiovascular Surgery, General University Hospital and the First Faculty of Medicine, de Saint-Etienne ~ Saint-Priest-en-Jarez ~ France Charles University ~ Prague ~ Czech Republic WORLD C36 PULMONARY ENDARTERECTOMY: BOLOGNA UNIVERSITY C30 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION EXPERIENCE SYMPOSIUM [1] [1] [2] [1] ON IN FIRSTLY DIAGNOSED PULMONARY EMBOLISM: INCIDENCE, Sofia Martin-Suarez* , Gregorio Gliozzi , Nazzareno Galiè , Davide Pacini PREDICTORS, AND PROGNOSTIC IMPLICATIONS [1]Cardiac Surgery Dept. S.Orsola Hospital ~ Bologna ~ Italy, [2]Dept. of Experimental, PULMONARY Kye Hun Kim*, Hyukjin Park, Jae Yeong Cho, Hyun Ju Yoon, Jong Chun Park Diagnostic and Specialty Medicine-DIMES, Bologna University ~ Bologna ~ Italy HYPERTENSION Chonnam National University Hospital ~ Gwangju ~ Korea, Republic of C37 MULTI-STEP THERAPY WITH RIOCIGUAT, BALLOON C31 FEASIBILITY AND SAFETY OF SHORTENING HOSPITAL STAY IN PULMONARY ANGIOPLASTY, AND CARDIAC REHABILITATION PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY FOR INOPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION TREATED WITH BALLOON PULMONARY HYPERTENSION Nice ANGIOPLASTY Takeshi Ogo*, Shigefumi Fukui, Yoichi Goto, Nao Konagai, Ryotaro Asano, February 27-28 / March 1, 2018 Mai Kimura*, Takashi Kohno, Takashi Kawakami, Masaharu Kataoka, Jin Ueda, Akihiro Tsuji, Yoshiaki Morita, Michio Nakanishi, Keiichi Fukuda, Toshimitsu Tsugu, Sarasa Isobe, Shinsuke Yuasa, Yuji Itabashi, Mitsushige Satoshi Yasuda, Michio Nakanishi Murata, Keiichi Fukuda National Cerebral and Cardiovascular Centre ~ Osaka ~ Japan Department of Cardiology, Keio University School of Medicine ~ Tokyo ~ Japan C38 RESIDUAL RIGHT VENTRICULAR REMODELING FOLLOWING C32 EVALUATION OF HEMODYNAMIC RESPONSES TO EXERCISE BALLOON PULMONARY ANGIOPLASTY IN CHRONIC IN PATIENTS WITH CTEPH AFTER BALLOON PULMONARY THROMBOEMBOLIC PULMONARY HYPERTENSION ANGIOPLASTY Takeshi Ogo*[1], Ryotaro Asano[1], Ohta-Ogo Keiko[2], Shigefumi Fukui[1], Akihiro Tsuji[1], Jin Ueda[1], Nao Konagai[1], Keiichi Fukuda[3], Yoshiaki Morita[3], Sugimura Koichiro*, Aoki Tatsuo, Tatebe Shunsuke, Yamamoto Saori, Yaoita [1] Nobuhiro, Sato Haruka, Kozu Katsuya, Konno Ryo, Shimokawa Hiroaki Satoshi Yasuda [1]Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Department of Cardiovascular Medicine, Tohoku University Graduate School of ~ Osaka ~ Japan, [2]Department of Pathology, National Cerebral and Cardiovascular Medicine ~ Sendai ~ Japan Center ~ Osaka ~ Japan, [3]Department of Radiology, National Cerebral and C33 CHANGES IN VESSEL DIAMETER AND LOCAL ELASTIC Cardiovascular Center ~ Osaka ~ Japan PROPERTIES OF PULMONARY ARTERIES AFTER BALLOON C39 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION PULMONARY ANGIOPLASTY. ASSOCIATED WITH CHRONIC SYNTHETIC CANNABINOIDS Wojciech Magon*, Jakub Stepniewski, Marcin Waligóra, Kamil Jonas, Piotr ‘BONZAI’ USE Podolec, Grzegorz Kopec Gül Öngen*[1], Ersan Atahan[1], Burçak Kiliçkiran Avci[3], Bedrettin Yildizeli[2] Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College [1]Istanbul University, Cerrahpasa Medical Faculity, Pulmonary Deparment ~ Istanbul at John Paul II Hospital ~ Krakow ~ Poland ~ Turkey, [2]Marmara University, Marmara Medical School, Thoracic Surgery ~ Istanbul ~ Turkey, [3]Istanbul University, Cerrahpasa Medical Faculity, Cardiology Deparment ~ C34 3D PRINTING IN PATIENTS WITH PULMONARY HYPERTENSION Istanbul ~ Turkey Athanasios Manginas*[1], Georgios Bobas[2] [1]Mediterraneo Hospital ~ Athens ~ Greece, [2]Univ. of Dundee ~ Dundee ~ United 44 Kingdom POSTER SESSIONS

Thursday, March 1, 2018 CTEPH

C40 PULMONARY BLOOD VOLUME BY DUAL-ENERGY CT IS A NEW C43 SUBCUTANEOUS TREPROSTINIL FOR THE TREATMENT OF MANAGEMENT INDEX FOR CHRONIC THROMBOEMBOLIC NON-OPERABLE CHRONIC THROMBOEMBOLIC PULMONARY PULMONARY HYPERTENSION HYPERTENSION: A RANDOMIZED, CONTROLLED TRIAL Hiroyuki Onishi*[1], Nakayama Kazuhiko[1], Yanaka Kenichi[1], Tamada Naoki[1], (CTREPH) Izawa Yuu[1], Shinkura Yuto[1], Tuboi Yasunori[1], Shimoyama Shinsuke[3], Nishii Roela Sadushi-Kolici*[4], Pavel Jansa[1], Grzegorz Kopec[2], Adam Torbicki[3], Tatsuya[3], Kono Atushi[3], Negi Noriyuki[2], Mori Shumpei[1], Otake Hiromasa[1], Ioana-Alexandra Campean[4], Gert Hoeffken[5], Nika Skoro-Sajer[4], Iveta Satomi-Kobayashi Seimi[1], Shinke Toshiro[1], Emoto Noriaki[4], Hirata Ken- Simkova[6], Kristof Karlocai[7], Regina Steringer-Mascherbauer[8], Miroslav Ichi[1] Samarzija[9], Barbara Salobir[10], Walter Klepetko[11], Jaroslav Lindner[12], Irene [1]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Marthe Lang[4] [2] University Graduate School of Medicine ~ Kobe ~ Japan, Division of Radiology, Center [1]Charles University of Prague, Cardiology ~ Prague ~ Czech Republic, [2]Department [3] for Radiology and Radiation Oncology, Kobe University Hospital ~ Kobe ~ Japan, of Cardiac and Vascular Diseases Jagiellonian University Medical College Centre for WORLD Department of Radiology, Kobe University Graduate School of Medicine ~ Kobe ~ Rare Cardiovascular Diseases John Paul II Hospital ~ Krakow ~ Poland, [3]John Paul II [4] Japan, Department of Clinical Pharmacy, Kobe Pharmaceutical University ~ Kobe ~ Hospital, Cardiac and Vascular Diseases Centre for Rare Cardiovascular Diseases ~ SYMPOSIUM Japan Warsaw ~ Poland, [4]Medical University of Vienna, Internal Medicine II, Cardiology ~ ON Vienna ~ Austria, [5]Internal Medicine I, Pulmonary Disease, University Carl Gustav Carus C41 REPEATED EMBOLIZATION COMBINED WITH INHIBITION ~ Dresden ~ Germany, [6]Slovak Medical University, Cardiology ~ Bratislava ~ Slovakia, [7] PULMONARY OF ANGIOGENESIS RESULTS IN EARLY CHRONIC Semmelweis University Heart Center, Cardiology ~ Budapest ~ Hungary, [8]Elisabethinen University Teaching Hospital, Cardiology ~ Linz ~ Austria, [9]University Hospital Centre HYPERTENSION THROMBOEMBOLIC PULMONARY HYPERTENSION IN RABBITS [10] [1] [1] [1] [3] Zagreb, Respiratory Diseases ~ Zagreb ~ Croatia, University Medical Centre of Rozenn Quarck* , Allard Wagenaar , Birger Tielemans , Frédéric Perros , Ljubljana, Internal Medicine, Pulmonary Diseases and Allergy ~ Ljubljana ~ Slovenia, [11] [3] [2] [2] Peter Dorfmüller , Catharina Belge , Marion Delcroix Medical University of Vienna, Thoracic Surgery ~ Vienna, Austria ~ Austria, [12]Charles [1]KU Leuven ~ Leuven ~ Belgium, [2]University Hospitals Leuven ~ Leuven ~ Belgium, [3] University of Prague , Cardiovascular Surgery ~ Prague ~ Czech Republic University Paris Sud ~ Le Plessis Robinson ~ France Nice C44 THE ESC/ERS RISK ASSESSMENT INSTRUMENT FOR PATIENTS February 27-28 / March 1, 2018 C42 PREVALENCE AND CHARACTERISTICS OF PATIENTS WITH WITH PULMONARY ARTERIAL HYPERTENSION IS ALSO CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION APPLICABLE IN CHRONIC THROMBOEMBOLIC PULMONARY FROM A SINGLE SINGAPORE CENTRE HYPERTENSION Wen Ruan*[1], Kevin Quah[1], Jonathan Yap[1], Aidila Binte Ismail[1], Duu Wen Anna Sandqvist*[1], David Kylhammar[2], Barbro Kjellström[3], Stefan Sewa[2], Ghee Chee Phua[2], Ai Leen Ang[2], Foong Koon Cheah[2], Kenny Söderberg[4] [1] [1] [1] [3] Loh , Chia Alicia Xue Fen , Choong Hee Lim , Jenkins David , Victor Tar [1]Department of Pharmacology and Clinical Neuroscience, Clinical Pharmacology, [1] [1] [1] Toong Chao , Soo Teik Lim , Ju Le Tan Umeå University ~ Umeå ~ Sweden, [2]Department of Clinical Physiology and [1]National Heart Centre Singapore ~ Singapore ~ Singapore, [2]Singapore General Department of Medicine and Health Sciences, Linköping University ~ Linköping ~ Hospital ~ Singapore ~ Singapore, [3]Papworth Hospital NHS trust ~ London ~ United Sweden, [3]Department of Medicine, Cardiology Unit, Karolinska Institute ~ Stockholm Kingdom ~ Sweden, [4]Department of Public Health and Clinical Medicine, Heart Centre, Umeå University ~ Umeå ~ Sweden C45 A TREATMENT GOAL TO IMPROVE RENAL FUNCTION AFTER BALLON PULMONARY ANGIOPLASTY IS REDUCING PULMONARY VSCULAR RESISTANCE IN PATIENTS WITH CHRONIC THROMBOLIC PULMONARY HYPERTENSION Isobe Sarasa*, Itabashi Yuji, Kawakami Takeshi, Kataoka Masaharu, Murata Mitsushige, Fukuda Keiichi Keio uninversity ~ Tokyo ~ Japan

45 POSTER SESSIONS

Thursday, March 1, 2018 CTEPH

C46 EARLY OUTCOMES FOLLOWING PULMONARY C51 PULMONARY ENDARTERECTOMY AND BALLOON PULMONARY ENDARTERECTOMY: AN AUSTRALIAN TERTIARY REFERRAL ANGIOPLASTY SIMILARLY IMPROVE HEALTH RELATED QUALITY CENTRE EXPERIENCE OF LIFE IN PATIENTS WITH CHRONIC THROMBOEMBOLIC Sarah Scheuer*[2], Sam Emmanuel[1], Anne Keogh[2], Joanna Pepke-Zaba[3], PULMONARY HYPERTENSION. David Jenkins[4], David Boshell[1], Eugene Kotylar[5], Kumud Dhital[2] Naoki Tamada*[1], Kazuhiko Nakayama[1], Ken-Ichi Yanaka[1], Hiroyuki Onishi[1], [1]St Vincent’s Hospital ~ Sydney ~ Australia, [2]St Vincent’s Hospital; Victor Chang Yuto Shinkura[1], Kazuhiro P Izawa[2], Toshiro Shinke[1], Noriaki Emoto[3], Ken- Cardiac Research Institute; University of New South Wales ~ Sydney ~ Australia, [3] Ichi Hirata[1] [4] Papworth Hospital; Cambridge University ~ Cambridge ~ United Kingdom, Papworth [1] [5] Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Hospital ~ Cambridge ~ United Kingdom, St Vincent’s Hospital; University of New Graduate School of Medicine ~ Kobe ~ Japan, [2]Graduate School of Health Sciences, South Wales ~ Sydney ~ Australia Kobe University ~ Kobe ~ Japan, [3]Clinical Pharmacy, Kobe Pharmaceutical University ~ Kobe ~ Japan WORLD C47 PREDICTORS FOR WORSENING HEMODYNAMICS DURING SYMPOSIUM FOLLOW-UP PERIOD AFTER BALLOON PULMONARY C52 POOR SUBPLEURAL PERFUSION RELATING TO LESS ON ANGIOPLASTY DEVELOPED BRONCHIAL ARTERIES PREDICTS FAILURE AFTER Yuto Shinkura*[2], Kazuhiko Nakayama[2], Hiroyuki Onishi[2], Kenichi Yanaka[2], BALLOON PULMONARY ANGIOPLASTY FOR NON-OPERABLE PULMONARY Naoki Tamada[2], Yasunori Tsuboi[2], Hiromasa Otake[2], Seimi Satomi- CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION [2] [2] [1] [2] HYPERTENSION Kobayashi , Toshiro Shinke , Noriaki Emoto , Ken-Ichi Hirata Yu Taniguchi*[2], Philippe Brenot[1], Xavier Jais[2], Carlos Garcia[1], Olivier [1]Department of Clinical Pharmacy, Kobe Pharmaceutical University, Japan ~ Kobe ~ Planche[2], Elie Fadel[1], Marc Humbert[2], Gerald Simonneau[2] Japan, [2]Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe [1]Hôpital Marie Lannelongue ~ PARIS ~ France, [2]Hôpital Universitaire de Bicêtre ~ University Graduate School of Medicine ~ Kobe ~ Japan PARIS ~ France Nice C48 A SIMPLE PREDICTIVE ALGORITHM FOR MORTALITY RISK IN February 27-28 / March 1, 2018 C53 THE WALL SHEAR STRESS OF THE PULMONARY ARTERIES CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN THE PATIENTS WITH CHRONIC THROMBOEMBOLIC Nika Skoro-Sajer*[1], Christian Gerges[1], Mario Gerges[1], Adelheid [1] [1] [2] PULMONARY HYPERTENSION BEFORE AND AFTER Panzenböck , Johannes Jakowitsch , Walter Klepetko , David BALLOON PULMONARY ANGIOPLASTY; ANALYSIS USING Celermajer[3], Irene Lang[1] [1] [2] COMPUTATIONAL FLUID DYNAMICS. Cardiology, Medical University of Vienna ~ Vienna ~ Austria, Department of [1] [1] [2] [1] Cardiothoracic Surgery ~ Vienna ~ Austria, [3]Sydney Medical School ~ Sydney ~ Hideo Tsubata* , Nakanishi Naohiko , Itatani Keiichi , Fukai Kuniyoshi , [2] [1] Australia Yaku Hitoshi , Matoba Satoaki [1]Kyoto Prefectural University of Medicine ~ Kyoto ~ Japan, [2]Department of C49 CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION Cardiovascular Surgery, Kyoto Prefectural University of Medicine ~ Kyoto ~ Japan MIMICS PULMONARY EMBOLISM Andris Skride*, Dana Kigitovica, Valdis Gibietis, Barbara Vitola, Sintija C54 HYDATID EMBOLIZATION RELATED CHRONIC PULMONARY Strautmane HYPERTENSION [1] [1] [1] [1] Dr ~ Riga ~ Latvia Omac Tufekcioglu* , Idris Yakut , Yucel Kanal , Ilke Erbay , Funda Dereagzi[1], Yesim Akin[1], Levent Birincioglu[2], Hatice Sasmaz[1] C50 SAFETY AND EFFICACY OF DIRECT ORAL ANTICOAGULANTS [1]Turkey Yuksek Ihtisas Hospital, Cardiology ~ Ankara ~ Turkey, [2]Turkey Yuksek Ihtisas FOR PATIENTS WITH CHRONIC THROMBOEMBOLIC Hospital, Cardiovascular Surgery ~ Ankara ~ Turkey PULMONARY HYPERTENSION IN ONE EXPERT CENTER IN JAPAN Rika Suda*, Nobuhiro Tanabe, Takayuki Jujo, Akira Naito, Rintaro Nishimura, Toshihiko Sugiura, Seiichiro Sakao, Koichiro Tatsumi Department of Respirology, Graduate School of Medicine, Chiba University ~ Chiba ~ Japan

46 POSTER SESSIONS

Thursday, March 1, 2018 CTEPH

C55 CASE SERIES OF SEVEN WOMEN WITH UTERINE FIBROIDS C57 ENDOTHELIAL PROGENITOR CELLS (EPCS) IN CHRONIC LEADING TO THROMBOEMBOLIC DISEASE AND CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH) THROMBOEMBOLIC PULMONARY HYPERTENSION Keiko Yamamoto*[2], Rintaro Nishimura[1], Akira Naito[2], Rika Suda[2], Takayuki Anjali Vaidya*[2], Anne-Sophie Lacharite-Roberge[1], Farhan Raza[2], Riyaz Jujo[1], Seiichiro Sakao[2], Nobuhiro Tanabe[1], Koichiro Tatsumi[2] Bashir[2], Chandra Dass[4], Yoshiya Toyoda[3], Paul Forfia[2] [1]Department of Advanced Medicine in Pulmonary Hypertension, Graduate School of [2] [1]Temple University Hospital Department of Medicine ~ Philadelphia ~ United States Medicine, Chiba University ~ Chiba ~ Japan, Department of Respirology, Graduate of America, [2]Temple University Hospital Heart and Vascular Institute ~ Philadelphia ~ School of Medicine, Chiba University ~ Chiba ~ Japan United States of America, [3]Temple University Hospital Department of Cardiovascular Surgery ~ Philadelphia ~ United States of America, [4]Temple University Hospital C58 PREDICTIVE POWER OF THE RISK STRATIFICATION SCORES FOR Department of Radiology ~ Philadelphia ~ United States of America PULMONARY HYPERTENSION IN PULMONARY EMBOLISM Yalin Tolga Yaylali*[1], Samet Yilmaz[1], Hande Senol[1], Omac Tufekcioglu[2] C56 INITIAL CLINICAL AND HEMODYNAMIC RESULTS OF A WORLD [1]Pamukkale University ~ Kinikli, Denizli ~ Turkey, [2]Yuksek Ihtisas Training and Research REGIONAL PULMONARY THROMBOENDARTERECTOMY Hospital ~ Ankara ~ Turkey SYMPOSIUM PROGRAM ON Anjali Vaidya*, Farhan Raza, Anne-Sophie Lacharite-Roberge, Chandra Dass, C59 PRACTICES SURROUNDING PULMONARY HYPERTENSION Riyaz Bashir, Toyoda Yoshiya, Paul Forfia AND BRONCHOPULMONARY DYSPLASIA AMONGST PULMONARY Temple Heart and Vascular Institute ~ Philadelphia ~ United States of America NEONATOLOGISTS CARING FOR PREMATURE INFANTS HYPERTENSION Gabriel Altit*, Henry Chong Lee, Susan Hintz, Theresa Tacy, Jeffrey Feinstein, Shazia Bhombal Stanford University ~ Palo Alto ~ United States of America Nice February 27-28 / March 1, 2018 PEDIATRIC PH

C60 PULMONARY ARTERY HYPERTENSION IS ASSOCIATED WITH C63 PEDIATRIC PULMONARY HYPERTENSION AT CHIDREN DECREASED CARDIAC OUTPUT IN FONTAN PATIENTS HOSPITAL “DR RICARDO GUTIERREZ”BUENOS AIRES. Vincent Aluquin*[1], Athira Nair[2], William Lee[3] ARGENTINA [1]Penn State Hershey Children’s Hospital ~ Hershey, Pennsylvania ~ United States of Mariana Elisa Cazalas*, Maria Grippo, Ines Abella, Haydee Vazquez, Maria America, [2]UCSF Fresno ~ Fresno, California ~ United States of America, [3]Penn State Sicurello, Alejandro Goldsman, Angela Sardella, Isabel Torres University ~ State College, PA ~ United States of America Argentine Society of Cardiology ~ Buenos Aires ~ Argentina C61 INTRAVENOUS TREPROSTINIL AND OCCULT FRACTURES IN C64 PEDIATRIC PULMONARY HYPERTENSION AND CONGENITAL INFANTS: MORE THAN A CASUAL CORRELATION? HEART DISEASE. EXPIERENCE AT CHILDREN HOSPITAL “DR. Meghan Bernier*, Lewis Romer RICARDO GUTIÉRREZ” BUENOS AIRES, ARGENTINA. Johns Hopkins School of Medicine ~ Baltimore ~ United States of America Mariana Elisa Cazalas*, Maria Grippo, Haydee Vazquez, Alejandro Goldsman, Maria Sicurello, Alberto Quilindro, Angela Sardella, Ines Abella C62 THE CARDIOPULMONARY EXERCISE TESTING IN CHILDREN Children Hospital Dr Ricardo Gutiérrez . Buenos Aires. Argentina ~ Buenos Aires ~ AND ADOLESCENTS WITH PULMONARY ARTERIAL Argentina HYPERTENSION. Mariana Cazalas*, Ines Abella, Alejandro Tocci, Claudio Moros, Maria Sicurello, Haydee Vazquez, Maria Grippo Argentine Society of Cardiology ~ Buenos Aires ~ Argentina 47 POSTER SESSIONS

Thursday, March 1, 2018 PEDIATRIC PH

C65 OUTCOMES OF TREATMENTS OF SELECTIVE PULMONARY C70 VENTRICULAR ARTERIAL COUPLING RATIO AND VOLUMES VASODILATORS AFTER THE TRANSCATHETER CLOSURE CORRELATE WITH RIGHT VENTRICULAR STRAIN AND IN ATRIAL SEPTAL DEFECT WITH PULMONARY ARTERIAL PREDICTS OUTCOMES USING THREE-DIMENSIONAL HYPERTENSION ECHOCARDIOGRAPHY IN PEDIATRIC PULMONARY Jae Young Choi*, Kim Jung Yoon, Kim Ah Young, Jung Jo Won, Jung Se HYPERTENSION Yong Pei-Ni Jone*, Michal Schäfer, Dunbar Ivy Division of Pediatirc Cardiology, Congenital Heart Disease Center, Severance Children’s Hospital Colorado, University of Colorado School of Medicine ~ Aurora ~ Cardiovascular Hospital, Department of Pediatrics, Yonsei University College of United States of America Medicine, Seoul ~ Seoul ~ Korea, Republic of C71 COMPARATIVE ANALYSIS OF DETERMINING RISK FACTORS OF WORLD C66 COMPARISON BETWEEN PAEDIATRIC AND ADULT PATIENTS PNEUMOTHORAX COMPLICATING PERSISTENT PULMONARY SYMPOSIUM WITH PULMONARY ARTERIAL HYPERTENSION HYPERTENSION OF THE NEWBORN IN THAI NEONATES Fabio Dardi*, Alessandra Manes, Massimiliano Palazzini, Elisa Zuffa, Enrico Narongsak Nakwan*, Sutthikiat Jaroensri, Wuttichart Kamolvisit ON Gotti, Andrea Rinaldi, Alessandra Albini, Enrico Monti, Daniele Guarino, Department of Pediatrics, Hat Yai Hospital ~ Songklha ~ Thailand PULMONARY Filippo Pasca, Nikita Tanese, Antonio Colangelo, Mariangela Rotunno, Andrea Donti, Nazzareno Galiè C72 A CASE OF ATRIAL SEPTAL DEFECT ASSOCIATED PULMONARY HYPERTENSION University of Bologna, Department of Specialized Diagnostic and Experimental ARTERIAL HYPERTENSION RELATED TO EISENMENGER’S Medicine – DIMES - Bologna/IT ~ Bologna ~ Italy SYNDROME C67 ATRIAL SEPTAL DEFECT FENESTRATED DEVICES IN CHILDREN Hidemi Sorimachi*, Noriaki Takama, Masahiko Kurabayashi WITH SEVERE PULMONARY HYPERTENSION Department of Cardiovascular Medicine, Gunma University Graduate School of Nice Medicine ~ Maebashi ~ Japan February 27-28 / March 1, 2018 Anne Fournier*, Francisco Gonzales-Barlatay, Maire-Josee Raboisson, Julie Briere, Nagib Dahdah C73 FIRST-IN-CHILD USE OF THE SOLUBLE GUANYLATE CYCLASE CHU mere-enfant Sainte-Justine ~ Montreal ~ Canada STIMULATOR RIOCIGUAT IN PULMONARY ARTERIAL C68 EPIDEMIOLOGICAL CHARACTERISTICS OF PULMONARY HYPERTENSION ARTERIAL HYPERTENSION IN THE PEDIATRIC POPULATION. Till Spreemann*, Christoph Happel, Harald Bertram, Georg Hansmann REGISTRATION OF A MEXICAN NATIONAL CENTER. Hannover Medical School ~ Hannover ~ Germany Humberto Garcia*, Emilia Covian, Sandra Patricia Antunez, Eduardo C74 IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION Melendez, Ramon Flores, Antonio Salgado IN PEDIATRICS: VALIDITY OF DOPPLER COLOR ISSSTE ~ Mexico ~ Mexico ECHOCARDIOGRAM FOR THE NON-INVASIVE DIAGNOSIS C69 ECONOMIC EVALUATION AND BUDGET IMPACT ANALYSIS Carolina Stepffer*, Adelia Marques, Julieta Rancati, Ines Martinez, Jesus OF A PEDIATRIC PULMONARY HYPERTENSION PROGRAM IN Damsky Barbosa MEXICO. hospital elizalde ~ buenos aires ~ Argentina [1] [2] [3] Humberto Garcia* , Silvia Guzman , Enrique Gomez Alvarez , Maria Emilia C75 CONGENITAL HEART DEFECT WITH PULMONARY Covian[3], Araceli Olivares[2], Herman Soto[2] [1] [2] [3] HYPERTENSION: IS POSSIBLE A SURGICAL CORRECTION AFTER ISSSTE ~ Mexico ~ Mexico, HS ~ Mexico ~ Mexico, ~ Mexico ~ Mexico TREATMENT WITH SILDENAFIL? Carolina Stepffer*, Maria Adelia Marques, Ines Martinez, Ana De Dios, Jesus Damsky Barbosa hospital elizalde ~ buenos aires ~ Argentina

48 POSTER SESSIONS

Thursday, March 1, 2018 PATIENTS’ PERSPECTIVES

C76 PHARMACOECONOMIC BURDEN OF PULMONARY HYPERTENSION IN DIFFERENT HEALTH CARE SYSTEMS Charles Burger D.*, Mohamedanwar Ghandour, Divya Padmanabhan Menon Mayo Clinic ~ Jacksonville, Florida ~ United States of America C77 INTERNATIONAL ENVIRONMENTAL SCAN OF SPECIALIZED PULMONARY HYPERTENSION CLINICS Carolyn Doyle-Cox*[1], Gail Nicholson[2], Wendy Gin-Sing[3], Traci Stewart[4] [1]University of Ottawa Heart Institue ~ Ottawa ~ Canada, [2]Alberta Health Services ~ Alberta ~ Canada, [3]Hammersmith Hospital ~ London ~ United Kingdom, [4]University of WORLD Iowa ~ Iowa ~ United States of America SYMPOSIUM C78 ORAL UPFRONT COMBINATION THERAPY IN PATIENTS WITH ON CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION: FROM A RETROSPECTIVE COHORT PULMONARY STUDY HYPERTENSION Kentaro Ejiri*, Satoshi Akagi, Toshihiro Sarashina, Kazufumi Nakamura, Hiroshi Ito Okayama University ~ Okayama ~ Japan Nice C79 ASSESSMENT OF LUNG ULTRASONOGRAPHY AS PREDICTOR February 27-28 / March 1, 2018 OF PULMONARY INVOLVEMENT IN A COHORT OF PATIENTS AFFECTED BY SYSTEMIC SCLEROSIS COMPLICATED BY EITHER INTERSTITIAL LUNG DISEASE OR PULMONARY ARTERIAL HYPERTENSION Elisa Tinazzi*, Federico Confente, Gloria Tacchella, Giuseppe Patuzzo, Claudio Lunardi University of Verona ~ Verona ~ Italy

49 GENERAL INFORMATION

CONGRESS LOCATION BADGES Nice Acropolis Congress Center Participants are requested to wear their congress badge during all Entrance for the public from Risso Boulevard, Nice sessions, coffee breaks, lunches. Ph: +33 (0)4 93 92 83 00 Badges colored stripes: Fax: +33 (0)4 93 92 82 55 RED: TASK FORCES BLUE: ATTENDEES OFFICIAL LANGUAGE YELLOW: SPONSORS The official language of the Symposium is English. GREY: ORGANIZATION STAFF

SECURITY CHECKPOINT REGISTRATION AND POSTER DESK For safety reasons, every person accessing to the Nice Acropolis The desks are open during the congress as follows: Congress Center has to go through a Security Checkpoint placed at Monday February 26 from 16.00 to 19.00 the entrance. We suggest to all participants to arrive in due time. Tuesday February 27 from 07.30 to 19.00 Wednesday February 28 from 08.00 to 17.30 REGISTRATION Thursday March 1 from 08.00 to 17.30 WORLD Every registered attendee can collect his/her congress kit at the SYMPOSIUM Registration Desk placed in Agora 1 after the main entrance. New INTERNET CONNECTION ON Registrations are accepted onsite only with payment by credit/debit All the congress venue is WIFI area – codes to access internet are: card. • WIFI name: wsph2018 PULMONARY • login: wsph2018 HYPERTENSION REGISTRATION FEES (VAT INCLUDED) • password: wsph2018 Registration Fee VOTING SYSTEM Poster presenters € 550,00 Through a WEBAPP the audience is kindly requested to attend the Nice February 27-28 / March 1, 2018 interactive part of each TF session. Instructions are given onsite. University & public/private hospital nurses* € 550,00 The use of the voting system is reserved to PHYSICIANS employed University & public/private hospital physicians* € 1.200,00 in Universities or Hospitals (no pharmaceutical companies staff); the Organizing Secretariat invites any participant to comply with this guideline. No-university/no-public/no-private hospital € 3.300,00 physicians and pharma companies representatives COFFEE BREAKS AND LUNCHES Reduced fee for staff members Coffee breaks are arranged in Agora 2, outside the Meeting Hall. € 1.650,00 of the sponsor companies Lunches are served in Agora 3, while desserts and coffees in Agora 2, next to the Posters Area. * To benefit from this Registration Fee, the participant must provide No accompanying person is allowed to access coffee breaks and the Organizing Secretariat with a document testifying his/her lunches during the Conference. affiliation to the University/Hospital. BAR The Registration Fee includes: Mykonos Bar is open during the Conference at Acropolis Center Admission to Scientific Sessions, congress kit, coffee breaks and (drinks upon payment). lunches. Accompanying persons are not accepted in the Congress Area. CERTIFICATE OF ATTENDANCE The certificate of attendance is available on request at the Registration Desk.

ABSTRACT BOOK The Posters Abstract Book is published on the Symposium Website: 50 www.wsph2018.com GENERAL INFORMATION

INFORMATION FOR SPEAKERS, POSTER PRESENTERS BESTS POSTER AWARDS CEREMONY AND AWARDED BEST POSTERS All winners are kindly requested to be present in Apollon hall on February 27 at 12.30 for the Best Poster Awards Ceremony. SPEAKERS: Slide center opening times Monday February 26 from 16.00 to 19.00 EACCME CREDITS Tuesday February 27 from 07.30 to 19.00 The 6TH WORLD SYMPOSIUM ON PULMONARY Wednesday February 28 from 08.00 to 17.30 HYPERTENSION, Nice, France, 27/02/2018- Thursday March 1 from 08.00 to 17.30 01/03/2018 has been accredited by the European Accreditation Council for Continuing Medical Speakers are kindly requested to reach our technical support team in Education (EACCME®) with 19 European CME the slide center not later than 2 hours before the relevant scheduled credits (ECMEC®s). Each medical specialist should session in order to copy the presentations onto the meeting claim only those hours of credit that he/she actually computer. spent in the educational activity. Presentations must be in Power Point and no personal computer is Through an agreement between the Union Européenne des allowed. Médecins Spécialistes and the American Medical Association, The operating system is Microsoft Windows Office and converter for physicians may convert EACCME® credits to an equivalent number WORLD Macintosh is available. of AMA PRA Category 1 Credits ™. Information on the process to SYMPOSIUM If the speech is at 9.00 in the morning, the speaker is kindly invited to convert EACCME® credit to AMA credit can be found at www.ama- ON deliver his/her slides the day before. assn.org/education/earn-credit-participation-international-activities. Live educational activities, occurring outside of Canada, recognised PULMONARY POSTER PRESENTERS: Mounting and dismounting rules by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited HYPERTENSION Touch screens are available in the Posters Area to find any poster and Group Learning Activities (Section 1) as defined by the Maintenance author name. of Certification Program of the Royal College of Physicians and The number of the corresponding panel (where the poster must be Surgeons of Canada. Nice fixed) is indicated near each name. February 27-28 / March 1, 2018 In the Posters Area, presenters can find the necessary material to EACCME® credits hang their posters. Each participant can only receive the number of credits he/she is Our staff is in assistance to the presenters to fix their posters in the entitled to, according to his/her actual participation at the event once Posters Area (Agora 2). he/she has completed the feedback form. Cf. criteria 9 and 23 of UEMS 2016.20. Mounting Time: In order to help you issue individual certificates to each participants, Any presenter must fix his/her poster/s on the assigned day from please find below the breakdown of ECMEC®s per day: 08.00 to 09.00. 27.02.2018 - 7,00 For presentations on February 27, poster mounting is allowed from 28.02.2018 - 6,00 7.30 to 9.00 and also the day before February 26 from 16.00 to 01.03.2018 - 6,00 19.00. The EACCME® awards ECMEC®s on the basis of 1 ECMEC® for one Dismounting Time: hour of CME with a maximum of 8 ECMEC®s per day. Cf. Chapter X Any presenter is requested to dismount his/her poster/s at the end of UEMS 2016.20. of the day of exhibition within 19.30. At 19.30 of the same day, our Organization will remove and eliminate all posters not dismounted.

POSTER PRESENTATION Although no poster discussion is planned, the poster presenters are kindly invited to be near their posters during lunch time in order to assist attendees interested in having information on their works. 51 GENERAL INFORMATION

TRANSPORTATION PALAIS DES CONGRÈS ACCESS PLAN Access to Nice Acropolis Congress Center Exit 55 A8 Nice Est From the airport: Auvare Park To To Take Bus n° 98 to the station ”cathédrale CANNES A8 vieille-ville”; then take the tramway towards MONACO “Hôpital Pasteur”; Stop at “Acropolis”. Parc auto Vinci Park 2 000 places

From the train station: Route deTurin Bd de Cimiez de Bd Route de Turin Bd Cessole Av. Borriglione Take the tramway towards “Hôpital Esplanade Bd. JBVerany Pasteur”; Stop at “Acropolis”. Mal. de Lattre Av. Mal. Lyautey de Tassigny Bd Pasteur Voie Bd. Sola Rapide

Bd Gambetta Tunnel St-Roch Bd From the A8 motorway “Provencal”: Bd. du Gal. Delfino André Malraux Palais des Congrès Av. des Diables Bleus Exit n° 50 towards “Nice Centre“ and the Delivery area Av. DesambroisACROPOLIS Av. Jean Médecin SNCF Bd Risso rail station “Promenade des Anglais“; then follow the Rue A. Gal

Pl. Garibaldi Bd de Riquier Av. Thiers Bd. Risso WORLD directions for “Acropolis“. Av. Galliéni (Expressway) Faure Bd Victor Hugo Av. Félix Pl. Masséna Nice SYMPOSIUM Mathis NICE TRAMWAY Bd JeanVieux Jaurès Nice castle ON Main entrance Albert 1er Quai des ACROPOLIS gardens Etats-Unis PALAIS DES CONGRÈS Voie PierreRue de France Nice inaugurated the first line of its Av. de la République is PORT PULMONARY gla To An tramway (T1) on November 24, 2007. The Rue Barla es Nice Côte d'Azur e d ITALy ad MEDITERRANEAN SEA Nice Côte d'Azur en HYPERTENSION line runs for 8.7 km and stretches from the AiRPORT om Pr northern tip of Nice, Nice-Nord (Boulevard TO THE PORT Nice Côte d'Azur Comte de Falicon) near the Ray Stadium Tram line Line 1 route "Acropolis" & "Palais des Expositions" stops and the A8 motorway, all the way to Nice February 27-28 / March 1, 2018 “Hôpital Pasteur”. Name of the tramway stop for the congress: ACROPOLIS. Due to Carnival Parades to be held on some days of the Symposium, the tram The processing will be carried out thanks to by contacting the Data Controller at the circulation could be redirected. adequate tools to guarantee security and addresses indicated above. For further information: privacy and can be carried out also through http://en.nicecarnaval.com/access- automatic tools that will memorize, manage USEFUL AND EMERGENCY NUMBERS transport-and-parking and transmit the data. TAXI: Tel.: +33(0)4 93 13 78 78 Images will be sent, communicated, shown AIRPORT: Tel: +33 820 42 33 33 PRIVACY POLICY AND DIFFUSION only to third parts appointed to carrying AMBULANCE: 15 OF THE IMAGES out the necessary activities for the purposes POLICE: 17 Pursuant to art. 13 of Legislative Decree mentioned above and will eventually be FIREFIGHTERS: 18 no. 196/2003, the personal data of the publicized through publications on the participants, the video footage and event website for the strict necessary time the photographs taken at the World to carry out the purposes of the processing. Symposium on Pulmonary Hypertension The Data Controller is I & C s.r.l., located in will be processed by I & C S.r.l. exclusively Bologna, Via Andrea Costa, 202/6 phone for purposes related to the communication +39 051 6144004, fax +39 051 6142772, and enhancement of this event. email address [email protected] The provision of personal data is optional, but In relation to the data provided, each any refusal to provide such data will not allow participant may exercise the rights referred 52 you to participate in video and photo shoots. to art. 7 of Legislative Decree no. 196/2003, AUTHORS AND TASK FORCES MEMBERS INDEX

Abe Kohtaro...... 22 Antigny Fabrice...... 15, 16, 18, 22, 23 Abella Ines...... 47 Antunez Sandra Patricia...... 48 Abman Steven...... 12 Aonuma Kazutaka...... 17, 18 Acar Serap...... 31 Apostolopoulou Olympia...... 31, 36 Adachi Shiro...... 42 Aranda Alvaro...... 39 Adams John...... 36, 37 Armagan Berkan...... 25 Adatia Ian T. K...... 12 Armaganidis Apostolos...... 19, 31, 35, 36 Aguirre-Zurita Oscar...... 40 Armstrong Iain...... 12 Ah Young Kim...... 48 Asano Ryotaro...... 44 Ahsan Fakhrul...... 15 Asano Yoshihiro...... 40 Akagi Satoshi...... 15, 49 Asil Serkan...... 25 Akdeniz Bahri...... 29, 31 Atahan Ersan...... 44 Akdogan Ali...... 25 Atamañuk Nicolas...... 34 Akgun Alperen Emre...... 42 Atas Halil...... 29 WORLD Akihiro Honda...... 36 Athanasopoulos Georgios...... 26, 27 Akin Yesim...... 46 Atsuko Tahara...... 36 SYMPOSIUM Akritidou Sofia...... 34 Atsumi Tatsuya...... 29, 35 ON Al Hilal Taslim A...... 15 Atushi Kono...... 45 PULMONARY Al-Mamun Elias...... 25, 39 Aueyingsak Sahachat...... 25 Al-Mamun Mohammad Elias...... 41 Auger Cyril...... 22 HYPERTENSION Alarco Walter...... 40 Auger William...... 13 Albanese Patricia...... 15 Austin Eric...... 20 Albiach-Montañana Cristina...... 41 Avgeropoulou Ekaterini...... 26, 27 Nice Albini Alessandra...... 31, 34, 35, 37, 40, 41, 42, 43, 48 Ayumi Sekine...... 15 February 27-28 / March 1, 2018 Aldred Micheala...... 8, 21 Bacharova Ljuba...... 25 Alexandra Arvanitaki...... 27 Badagliacca Roberto...... 24 Alice Huertas...... 15, 18 Badesch David B...... 9, 20 Alicia Xue Fen Chia...... 45 Badlam Jessica...... 20 Alonso-Gonzalez Rafael...... 26 Bagalas Vasileios...... 34 Altit Gabriel...... 22, 28, 47 Bailly Sabine...... 19 Aluquin Vincent...... 47 Baird Grayson...... 19 Aman Jurjan...... 18 Baldus Stephan...... 31, 33, 38, 40 Amélie Cumont...... 18 Balint Olga Hajnalka...... 35 Amissi Said...... 22 Bang Oh Young...... 28 Ammirati Enrico...... 40 Barbera Joan A...... 17 Anderson Stephanie...... 39 Barberà Joan Albert...... 11, 13, 32, 38 Andreas Rieth...... 43 Baris Nezihi...... 31 Andrew Ruth...... 16 Barnes Hayley...... 40, 42 Andrijevic Ana...... 29 Barr R Graham...... 19 Andrijevic Ilija...... 29 Barreira Bianca...... 17 Anegon Igniacio...... 16 Bartfay Sven-Erik...... 26 Ang Ai Leen...... 43, 45 Barth Angeles...... 23 Anggrahini Dyah Wulan...... 25, 26, 33 Bashir Riyaz...... 47 Anneliese Larose...... 39 Batool Mahreen...... 19 Anthi Anastasia...... 26, 27, 31, 35, 36 Bauer Uta-Maria...... 20 53 AUTHORS AND TASK FORCES MEMBERS INDEX

Baumgartner Helmut...... 35 Bondue Antoine...... 24, 40 Bazmpani Maria Anna...... 27 Bonnet Damien...... 12, 21 Beghetti Maurice...... 12 Bonnet Dominique...... 15 Behr Jürgen...... 37 Bonnet Sebastien...... 8 Belchi Joaquina...... 41 Boomars Karin...... 23 Belevskaya Anna...... 35 Boonstra Anco...... 32 Belge Catharina...... 18, 19, 45 Bordenave Jennifer...... 15, 19 Belhaj Asmae...... 23 Bortman Guillermo...... 34 Benas Dimitris...... 36 Boshell David...... 46 Bengus Monica...... 37 Bossone Eduardo...... 14, 38 Benjamin Nicola...... 14, 20, 29, 39 Boucly Athénaïs...... 31, 42 Benza Ray...... 20 Bourdin Arnaud...... 21 Benza Raymond L...... 10 Boutou Afroditi...... 34 WORLD Bergen Ingrid...... 23 Bouzina Habib...... 28, 30 Berger Rolf M.F...... 12 Breijer Fabian...... 18 SYMPOSIUM Berghausen Eva...... 19 Brenot Philippe...... 46 ON Berjaoui Wael...... 42 Briere Julie...... 48 PULMONARY Berman Rosenzweig Erika...... 12 Brili Styliani...... 31 Bernier Meghan...... 15, 47 Brimioulle Serge...... 23 HYPERTENSION Bertoletti Laurent...... 44 Brown Lynette...... 43 Bertram Harald...... 48 Brown Zoe...... 40, 42 Best Hunter...... 43 Bru-Mercier Gilles...... 16 Nice Bhatta Anil...... 15 Brunner Nathan W...... 41 February 27-28 / March 1, 2018 Bhombal Shazia...... 22, 28, 47 Bruschi Eleonora...... 25 Bigorgne Amélie...... 18 Buendia-Fuentes Francisco...... 35 Bilge Ahmet Kaya...... 30, 35 Burban Mélanie...... 22 Bingol Zuleyha...... 30 Burgel Pierre-Regis...... 42 Birincioglu Levent...... 46 Burns Andrew...... 40, 42 Birkfellner Wolfgang...... 43 Busse Dennis...... 33 Bischoff Florian...... 19 Butane Lina...... 38 Blackwater Tyler...... 24 Byun Kyunghee...... 15, 20, 39 Blanco Isabel...... 38 Cai Zongye...... 15, 23, 25 Blank Norbert...... 14 Caillat-Zucman Sophie...... 13 Bleda Marta...... 13, 21 Campean Ioana-Alexandra...... 45 Blenkhorn Fay...... 24 Cannon John...... 13 Bloch Konrad E...... 16 Canuet Mathieu...... 22 Bluemke David...... 19 Cao Aiqin...... 17 Bobas Georgios...... 44 Capuano Véronique...... 23 Boeckel Jes-Niels...... 19 Caravita Sergio...... 24, 40 Boehm Nelly...... 22 Cardenas-Tealdo Juan Pablo...... 41 Boet Angele...... 16, 23 Carole Phan...... 15, 18 Bogaard Harm Jan...... 13, 15, 17, 21 Carolino D’Araujo Sandy...... 40 Bohacekova Marcela...... 25, 42, 44 Caruso Nicolas...... 34 Bohgaki Toshiyuki...... 29, 35 Casado-Arroyo Rubén...... 34 54 Böhm Mario...... 24 Castan Agnès...... 19 AUTHORS AND TASK FORCES MEMBERS INDEX

Catravas John...... 24 Cipriani Manlio Gianni...... 40 Cazalas Mariana Elisa...... 47 Cittadini Antonio...... 14, 38 Celermajer David S...... 9, 23, 30, 35, 40, 41, 46 Clapp Lucie H...... 37 Cetinarslan Ozge...... 26 Codde Jim...... 30, 41 Ceyhan Berrin...... 29 Coghlan Gerry...... 13, 21, 29 Cha Jihoon...... 28 Coghlan John...... 11 Chakinala Murali...... 38 Cogolludo Angel...... 17 Chamorro-Fernández Carlos Israel...... 35 Cohen-Kaminsky Sylvia...... 13, 15, 16, 30 Chang Hao-Chih...... 23 Colangelo Antonio...... 31, 34, 35, 37, 41, 42, 43, 48 Chang Hsiang-Yuan...... 29 Cole Michele...... 34 Chang Hyuk Jae...... 33, 38 Colvin Johanna...... 38 Chang Sung-A...... 28, 38 Condliffe Robin...... 21 Chang Wei-Ting...... 29 Confente Federico...... 49 Channick Richard N...... 10, 24 Coronel Maria Lorena...... 34 WORLD Chantepie Sandrine...... 15 Corris Paul A...... 10, 13, 21 Chao Victor Tar Toong...... 43, 45 Corso Pereira Mônica...... 28 SYMPOSIUM Chaouat Ari...... 21 Cottin Vincent...... 21 ON Charles D Burger...... 49 Courboulin Audrey...... 15, 16 PULMONARY Chassagnon Guillaume...... 42 Courtier Anais...... 13 Chazova Irina...... 11, 35, 36 Covian Emilia...... 48 HYPERTENSION Cheah Foong Koon...... 43, 45 Covian Maria Emilia...... 48 Chelabi Samy...... 42 Crippa Diego...... 23 Chelladurai Prakash...... 16, 20 Cristos Feloukidis...... 27 Nice Chen Frederick Y...... 23 D’’Angelo Luciana...... 25, 40 February 27-28 / March 1, 2018 Chen I-Chen...... 40 Dabral Swati...... 16, 24 Chen Pin-I...... 17 Dahdah Nagib...... 48 Chen Wei...... 19 Dai Zen-Kong...... 40 Chew Benjamin...... 26, 28 Dai-Yin Lu...... 23 Chia Alicia Xue Fen...... 43 Damico Rachel...... 14 Chih-Hsin Hsu...... 30 Dammann Reinhard...... 16 Chin Kelly Marie...... 9, 38 Damsky Barbosa Jesus...... 48 Cho Jae Yeong...... 44 Danesino Cesare...... 21 Cho Myeong-Chan...... 40 Dardi Fabio...... 31, 34, 35, 37, 40, 41, 42, 43, 48 Cho Young Seok...... 28 Dartevelle Philippe...... 15 Choi Hanul...... 15, 20, 39 Daru Victor...... 23, 29 Choi Jae Young...... 33, 38, 48 Das Tridib...... 23 Choi Jung Hyun...... 34 Dass Chandra...... 47 Choi Seungbum...... 15, 20, 39 Daugherty Louise C...... 21 Chomette Laura...... 40 David Jenkins...... 45 Chong Lee Henry...... 47 David Montani...... 39 Christophe Guignabert...... 15, 18 Davies Rachel...... 32 Chung Kevin...... 15, 30, 41 De Dios Ana...... 48 Chung Wendy Kay...... 8, 20 De Marco Teresa...... 11 Chung Wook-Jin...... 20, 39 De Montpréville Vincent Thomas...... 17 Church Colin...... 21 De Perrot Marc...... 10 55 AUTHORS AND TASK FORCES MEMBERS INDEX

De Raaf Michiel...... 23 El-Nikhely Nefertiti...... 18 Dean Afshan...... 23 Elding Heather...... 13 Delavenne Xavier...... 44 Elias-Al-Mamun Mohammad...... 17 Delcroix Marion...... 12, 13, 18, 19, 32, 38, 45 Elliott Gregory...... 8, 20, 43 Demerouti Eftihia...... 26, 27 Emmanuel Sam...... 46 Demir Rengin...... 26 Emoto Noriaki...... 14, 28, 46 Demolli Shemsi...... 19 Endo Jin...... 24 Denis Migdalia...... 12 Epis Oscar Massimiliano...... 25 Denton Christopher P...... 9, 29 Erbay Ilke...... 46 Denver Nina...... 16 Erden Abdulsamet...... 25 Dereagzi Funda...... 46 Erdogan Okan...... 29 Detterich Jon...... 19 Escribano-Subias Pilar...... 32, 36 Dewachter Céline...... 23, 40 Evyapan Fatma...... 42 WORLD Dewachter Laurence...... 23, 24 Ewert Ralf...... 39 Dhital Kumud...... 46 Eyries Mélanie...... 21 SYMPOSIUM Diab Nermin...... 14 Fabregat-Andrés Oscar...... 41 ON Dillberger John...... 39 Fabrice Antigny...... 17 PULMONARY Dimitris Benas...... 36 Fadel Elie...... 10, 15, 16, 17, 23, 30, 46 Dimitrova Elena...... 31 Faini Andrea...... 40 HYPERTENSION Dimmeler Stefanie...... 19 Faoro Vitalie...... 24 Dimopoulos Konstantinos...... 26 Farber Harrison...... 20, 27, 36, 38 Dinarti Lucia Kris...... 25, 26, 33 Farina Juan...... 23, 29, 34 Nice Distler Oliver...... 29 Farré Marti Richard...... 19 February 27-28 / March 1, 2018 Docherty Craig...... 16, 23 Feige Jean-Jacques...... 19 Dodson Mark...... 43 Feinstein Jeffrey...... 22, 28, 47 Doelberg Martin...... 29 Feldkircher Kathy...... 20 Donti Andrea...... 48 Feloukidis Christos...... 31 Dorfmüller Peter...... 8, 13, 15, 16, 17, 30, 45 Ferrando Monica...... 41 Doundoulakis Ioannis...... 27 Ferrari Pisana...... 12 Doyle-Cox Carolyn...... 49 Fesler Pierre...... 23, 40 Drake William...... 34 Fiehn Christoph...... 14 Droma Yunden...... 22 Filipe-Santo Orchidee...... 13 Dromer Claire...... 21 Fine Nowell...... 33 Dumas Sébastien J...... 13, 15, 16 Fink Ludger...... 18, 43 Dumitrescu Daniel...... 31, 33, 38, 40 Finkov Bozhidar...... 31 Duncker Dirk Jan...... 15, 23, 25 Firat Esra...... 25 Dunning John...... 13 Fischer Christine...... 14, 20, 29 Durmus Nedim...... 16 Florence Parent...... 39 Durmus Sinan...... 42 Flores Ramon...... 48 Egenlauf Benjamin...... 14, 39 Foderaro Andrew...... 19 Eichstaedt Christina A...... 14, 16, 20, 38 Forfia Paul...... 47 Einarsson Gunnar...... 16 Forsythe Clint...... 39 Eita Kumagai...... 36 Forton Kevin...... 24 Ejiri Kentaro...... 49 Fournier Anne...... 48 56 El-Gazayerly Amany N...... 10 Franco Veronica...... 32 AUTHORS AND TASK FORCES MEMBERS INDEX

Frantz Robert P...... 10 Girerd Barbara...... 13, 15, 16, 17, 18, 21, 30 Frantzeskaki Frantzeska...... 19, 31, 35 Girgis Reda...... 42 Frey Maria...... 43 Giubertoni Ailia...... 16 Frigerio Maria...... 25, 40 Glaser Simone...... 19 Fritz Jason...... 19 Gliozzi Gregorio...... 44 Frogoudaki Alexandra...... 31 Goda Ayumi...... 14, 43 Frossard Nelly...... 15 Gokhan Sonmez...... 41 Frost Adaani...... 9, 20 Goldsman Alejandro...... 47 Fujieda Yuichiro...... 29 Gomberg Maitland Mardi I...... 10 Fukiko Ichida...... 14 Gomez Alvarez Enrique...... 48 Fukuda Keiichi...... 24, 44 Gómez Sánchez Miguel Angel...... 32 Fukui Shigefumi...... 44 Gomez Santa Maria Hector...... 23, 29 Fumitaka Tajima...... 28, 42 Gonzales-Barlatay Francisco...... 48 Furukawa Asuka...... 28, 32 Gonzalez Miguel...... 29 WORLD Gabriel Harald...... 35 Gonzalez Nicolas...... 29 Gaine Sean P...... 11, 38 Gopalan Deepa...... 9 SYMPOSIUM Galiè Nazzareno...... 8, 10, 12, 31, 34, 35, 37, 40, 41, 42, 43, 44, 48 Goto Yoichi...... 44 ON Gall Henning...... 18, 21, 32 Gotti Enrico...... 31, 34, 35, 37, 40, 41, 42, 43, 48 PULMONARY Galvez David...... 40 Gouadon Elodie...... 16 Gamen Elisabetta...... 16 Gräf Stefan...... 13, 21 HYPERTENSION Garascia Andrea...... 25, 40 Grancelli Hugo...... 29 Garcia Brasca Daniela...... 34 Granton John...... 10 Garcia Carlos...... 46 Gravellone Miriam...... 16 Nice Garcia Humberto...... 48 Gregorc Teja...... 23 February 27-28 / March 1, 2018 García-González Maria Pilar...... 41 Gregorietti Vanesa...... 34 Garnett Christine...... 10 Grimminger Friedrich...... 16, 18 Gattenlöhner Stefan...... 18 Grippo Maria...... 47 Gatzoulis Michael A...... 9, 26 Grünberg Katrien...... 15 Georgios Karanikas...... 43 Grünig Ekkehard...... 10, 14, 16, 20, 29, 32, 33, 38, 39 Gerald Simonneau...... 39 Grunig Gabriele...... 16 Gerges Christian...... 23, 35, 40, 43, 46 Grzegorz Kopec...... 33 Gerges Mario...... 23, 35, 40, 43, 46 Guarino Daniele...... 31, 34, 35, 37, 41, 42, 43, 48 Gerhardt Felix...... 31, 33, 38, 40 Guazzi Marco...... 11 Ghandour Mohamedanwar...... 49 Guerrero Oscar...... 40 Ghigna Maria Rosa...... 18, 17 Guignabert Christophe...... 8, 15, 18, 19, 28, 30 Ghio Stefano...... 21, 38 Gumbiene Lina...... 38 Ghofrani Hossein-Ardeschir...... 12, 18, 21, 24, 32, 33, 43 Guth Stefan...... 43 Giannakoulas George...... 26, 27, 31 Guzman Silvia...... 48 Gibbs Simon...... 9, 13, 21, 32 Hacker Marcus...... 43 Gibietis Valdis...... 46 Haddad François...... 9 Giglio Ada Francesca...... 40 Hadinnapola Charaka...... 13, 21 Gijsbers Rik...... 19 Hagmanns Henrik...... 31 Gilberg Frank...... 37 Haick Hossam...... 30 Gin-Sing Wendy...... 32, 49 Haimel Matthias...... 21 Giovinazzo Michele...... 24 Hajime Kasai...... 43 57 AUTHORS AND TASK FORCES MEMBERS INDEX

Halank Michael...... 32 Hiroyuki Fukushima...... 14 Hanaoka Masayuki...... 22 Hiroyuki Onishi...... 42 Handoko De Man Frances...... 38 Hirschson Prado Alfredo...... 23 Hansmann Georg...... 48 Hisada Ryo...... 35 Hantash Manal...... 39 Hitoshi Yaku...... 46 Happel Christoph...... 48 Hjalmarsson Clara...... 26, 33 Haralambos Karvounis...... 27 Hodgson Joshua...... 21 Harari Sergio...... 11, 37 Hodin Sophie...... 44 Harmjan Bogaard...... 23 Hoeffken Gert...... 45 Harris R Scott...... 24 Hoeper Marius M...... 10, 20, 32 Hartline Brian...... 38 Hohmann Christopher...... 33 Hartopo Anggoro Budi...... 25, 26, 33 Holden Simon...... 21 Haruka Sato...... 44 Homer Natalie...... 16 WORLD Harutyunova Satenik...... 14, 20, 29 Homma Satoshi...... 18 Harvey Katie Yates...... 16 Honda Junya...... 18 SYMPOSIUM Hassoun Paul M...... 9, 14 Hoo Teng Yik...... 26, 28 ON Hatala Robert...... 25 Hopkins Susan R...... 9 PULMONARY Hatem Stéphane...... 23 Horiuchi Toshimichi...... 22 Hautefort Aurélie...... 15, 16, 18, 22, 23 Hoshikawa Yasushi...... 17, 25 HYPERTENSION Haworth Busk Sheila G...... 12 Houeijeh Ali...... 21 Hekimsoy Vedat...... 25 Houweling Arjan C...... 21 Hellmich Martin...... 40 Howard Luke S...... 12, 21, 32 Nice Helmersen Douglas...... 32, 33 Hsu Chih-Hsin...... 23, 29, 42 February 27-28 / March 1, 2018 Hemnes Anna R...... 9, 38 Hsu Jong-Hau...... 40 Henault Emilie...... 15 Huang Wei-Ming...... 26 Hendriks Rudi...... 23 Huckell Victor F...... 41 Hennigs Jan...... 17 Huertas Alice...... 15, 18, 19 Henrohn Dan...... 16 Hull Michael...... 34 Herth Felix...... 39 Humbert Marc...... 8, 13, 15, 16, 17, 18, 19, 21, 22, 23, 28, 30, 31, 32, 33, 39, 42, 46 Heukels Peter...... 23 Hummel Regina...... 19 Hibert Marcel...... 15 Hunt Thomas...... 39 Hidenori Moriyama...... 22 Hyung-Kwan Kim...... 34 Highland Kristin...... 38 Ichimura Yuki...... 33 Higuchi Tomoaki...... 33 Ikeda Shohei...... 41 Hill Jerrold...... 34 Ikonomidis Ignatios...... 36 Hill Nicholas...... 19 Iloska Dijana...... 43 Hinderhofer Katrin...... 14, 20 Inami Takumi...... 14, 43 Hintz Susan...... 47 Inanc Murat...... 30, 35 Hiraide Takahiro...... 24 Ishibashi-Ueda Hatsue...... 17 Hirani Naushad...... 33 Ishiguro Haruhisa...... 14, 43 Hirata Ken-Ichi...... 14, 46 Ismail Aidila Binte...... 45 Hiroaki Shimokawa...... 44 Isobe Sarasa...... 24, 44 Hirofumi Sawada...... 14 Issever Halim...... 35 Hiromasa Otake...... 45 Itabashi Yuji...... 24, 44 58 Hiroshi Ito...... 27 Ito Hiroshi...... 49 AUTHORS AND TASK FORCES MEMBERS INDEX

Ivy Dunbar...... 12, 48 Kawakami Takashi...... 24, 44 Izawa Kazuhiro P...... 46 Kawamori Hiroyuki...... 14 Jaé Nicolas...... 19 Kawut Steven M...... 9, 19 Jaïs Xavier...... 12, 17, 31, 42, 46 Kazufumi Nakamura...... 27 Jakowitsch Johannes...... 35, 43, 46 Kazuhiko Nakayama...... 22, 42, 45 Jakub Stepniewski...... 33 Kazuya Miyagawa...... 22 Jang Shin Yi...... 28 Keating Mike...... 38 Jansa Pavel...... 32, 33, 44, 45 Keiichi Fukuda...... 22, 45 Janssen Wiebke...... 24 Keiichi Ishida...... 43 Jaroensri Sutthikiat...... 48 Keiichi Itatani...... 46 Jenkins David P...... 12, 13, 43, 46 Keiko Ohta-Ogo...... 44 Jennifer Bordenave...... 18 Kempny Aleksander...... 26 Jeon Chan Hong...... 34 Ken-Ichi Hirata...... 42, 45 Jeries Raneen...... 30 Kenichi Yanaka...... 42, 45 WORLD Jevnikar Mitja...... 31 Kentaro Ejiri...... 27 Jin Endo...... 22 Keogh Anne...... 46 SYMPOSIUM Jing Zhi Cheng...... 10 Keogh Anne M...... 10, 36 ON Jo Won Jung...... 48 Kepez Alper...... 29 PULMONARY John David...... 19 Kerbaul Francois...... 23 Johnson Martin...... 38 Keshavarz Ali...... 15 HYPERTENSION Jonas Kamil...... 44 Kessler Romain...... 22 Jone Pei-Ni...... 48 Khanna Dinesh...... 9 Jourdon Philippe...... 23 Khatib Salam...... 30 Nice Jujo Takayuki...... 35, 43, 46, 47 Khrisanapant Wilaiwan...... 25 February 27-28 / March 1, 2018 Jung Hae Ok...... 15, 20 Ki Chang Seok...... 28 Jung Jo Won...... 33, 38 Kiely David G...... 13, 21, 38 Jung Se Yong...... 33, 38 Kigitovica Dana...... 46 Jung Yoon Kim...... 48 Kikuchi Hanako...... 14, 43 Jutant Etienne-Marie...... 18 Kikuchi Nobuhiro...... 17, 25, 39, 41 K F Oliveira Rudolf...... 23 Kiliçkiran Avci Burçak...... 34, 44 Kaldararova Monika...... 25, 35, 42, 44 Kim Duk-Kyung...... 15, 28, 38 Kamil Jonas...... 33 Kim Hyung Kwan...... 38 Kamolvisit Wuttichart...... 48 Kim Kye Hun...... 44 Kanal Yucel...... 46 Kim Kyung-Hee...... 20, 39 Kanar Batur Gonenc...... 29 Kim Minsu...... 39 Kap Miriam...... 38 Kim Nick H...... 12, 38 Kaptan Ozen Deniz...... 29 Kim So Ree...... 28 Karatancheva Blagorodna...... 31 Kim Sung Mok...... 28 Kariofillis Panagiotis...... 26, 27 Kim Tae Jung...... 28 Karlocai Kristof...... 45 Kimio Satoh...... 39 Karvounis Haralambos...... 26, 27, 31 Kimura Mai...... 24, 44 Kataoka Masaharu...... 14, 24, 43, 44 Kimura Taizo...... 18 Kato Masaru...... 29, 35 Kinota Fumiya...... 22 Katsuya Kozu...... 44 Kioka Hidetaka...... 40 Kawaguchi Yasushi...... 33 Kirchgaessler Klaus-Uwe...... 37 59 AUTHORS AND TASK FORCES MEMBERS INDEX

Kitaichi Masanori...... 17 Kurosawa Ryo...... 17, 25, 39, 41 Kjellström Barbro...... 26, 33, 45 Kwon Hee-Jin...... 40, 41 Klassen Preston...... 36 Kwon Woo Chan...... 28 Kleinjung Frank...... 39 Kylhammar David...... 26, 33, 45 Klepetko Walter...... 10, 43, 45, 46 Kyung-Hee Kim...... 34 Klingel-Schmitt Isabelle...... 13 Kyzymly Aigun...... 24 Klinger James R...... 8, 19 Lacharite-Roberge Anne-Sophie...... 47 Klose Hans...... 32 Lambert Melanie...... 15, 16, 17, 22, 23 Klotsche Jens...... 32 Lang Irene...... 11, 13, 23, 35, 40, 43, 45, 46 Klyaus Nataliya...... 29 Lange Tobias...... 32, 34 Knox Michael...... 42 Langholz David...... 42 Kobayashi Nobumitsu...... 22 Langleben David...... 9, 24, 32 Kobayashi Seimi...... 14 Larsson Marita...... 16 WORLD Kocakaya Derya...... 29 Lau-Walker Margaret...... 32 Koep Eleena...... 34 Laurent Savale...... 39 SYMPOSIUM Kohli Puja...... 24 Lavalle Cobo Augusto...... 23, 29 ON Kohno Takashi...... 24, 44 Lawrie Allan...... 21 PULMONARY Koichiro Sugimura...... 44 Lecerf Florence...... 15, 16, 18 Koichiro Tatsumi...... 17, 43 Lechner Klaus...... 43 HYPERTENSION Koji Ikeda...... 22 Lee Byeong-Ju...... 15, 34 Kojonazarov Baktybek...... 18, 24 Lee Geraldine...... 32 Kolb Todd...... 14 Lee Ju-Hee...... 40, 41 Nice Kolios Marios...... 31 Lee Jun Soo...... 20 February 27-28 / March 1, 2018 Konagai Nao...... 44 Lee Lisa...... 41 Konstandinides Stavros...... 26, 27 Lee Sang Eun...... 33 Konstantonis Dimitrios...... 19, 31, 35 Lee Shin-Seok...... 34 Kool Mirjam...... 23 Lee William...... 47 Kopec Grzegorz...... 36, 44, 45 Lehmkuhl Hans...... 39 Kostantonis Dimitris...... 36 Lekakis John...... 35, 36 Kotsimbos Tom...... 23 Leroy Anne...... 21 Kotylar Eugene...... 46 Lescano Adrian...... 23, 29, 34 Koudstaal Thomas...... 23 Lescano Miguel...... 40 Kovacs Gabor...... 21, 38 Levy Marilyne...... 21 Kramer Tilmann...... 31, 33, 38, 40 Levy Robert D...... 41 Kreitner Karl-Friedrich...... 19 Lewis Michael I...... 10 Krombach Gabriele...... 18 Leys Mathias...... 19 Krowka Michael...... 9 Li Caiyun...... 17 Kubota Kana...... 26 Li Wei...... 21 Kucukoglu Mehmet Serdar...... 26 Liao Ronglih...... 23 Kühn Christian...... 10 Lickert Cassandra...... 34 Kukongviriyapun Upa...... 25 Liebetrau Christoph...... 43 Kultursay Hakan...... 29 Lim Choong Hee...... 28, 45 Kuniyoshi Fukai...... 46 Lim Soo Teik...... 26, 43, 45 Künne Carsten...... 20 Lima Joao...... 19 60 Kurabayashi Masahiko...... 48 Lindner Jaroslav...... 44, 45 AUTHORS AND TASK FORCES MEMBERS INDEX

Liu Bin...... 21 Masaki Matsushima...... 14 Liu Wei-Shin...... 29 Masanori Yasuo...... 42 Loh Kenny Wei-Tsen...... 43, 45 Masashi Yanagisawa...... 22 Looso Mario...... 20 Masayuki Hanaoka...... 42 Lorenz Hanns-Martin...... 14 Mascherbauer Regina...... 32 Low Andrea...... 26, 28 Maslyanskiy Alexey...... 29 Loyd James E...... 8 Mateo Maria Paz...... 27 Lu Wei-Da...... 29 Mathai Stephen C...... 10, 14 Lumens Joost...... 9 Matijasevic Jovan...... 29 Lunardi Claudio...... 49 Matsubara Hiromi...... 12, 17, 34, 43 Lutz Katie...... 13 Matthieu Turpin...... 39 Ly Tu...... 15, 18 Mayer Eckhard...... 12, 13, 43 Lydell Carmen...... 33 Mccabe Colm...... 26 Macera Francesca...... 40 McGoon Michael D...... 12 WORLD Machado Ferreira Eloara...... 23 McLaughlin Vallerie V...... 8, 10, 12, 36, 38 Machado Rajiv D...... 21 Mehta Sanjay...... 12 SYMPOSIUM Mackenzie Alison...... 38 Meier Christian...... 32, 33 ON Mackenzie Ross Robert V...... 21 Melendez Eduardo...... 48 PULMONARY Maclean Margaret...... 16, 23 Melero-Ferrer Josep Lluís...... 35 Madani Michael M...... 12 Ménoret Séverine...... 16 HYPERTENSION Magon Wojciech...... 36, 44 Mercier Olaf...... 17 Mairbäurl Heimo...... 20 Mercurio Valentina...... 14 Mal Herve...... 42 Mergenthaler Nicoletta...... 34 Nice Malikov Kirill...... 29 Merkus Daphne...... 15, 23, 25 February 27-28 / March 1, 2018 Mallet Christine...... 19 Messina Carolina M.S...... 23 Mamazhakypov Argen...... 24 Meziani Ferhat...... 22 Manes Alessandra...... 9, 31, 34, 35, 37, 40, 41, 42, 43, 48 Michalik Katharina...... 19 Manginas Athanasios...... 26, 27, 31, 44 Michel Jean-Baptiste...... 23 Manoury Boris...... 16, 22 Michiels Annelies...... 19 Marcin Waligora...... 33 Mielniczuk Lisa...... 32 Margelidon-Cozzolino Victor...... 44 Milutinov Senka...... 29 Maria Toumpourleka...... 27 Mitrakou Cornelia...... 31 Marino Paolo Nicola...... 16 Mitrouska Ioanna...... 26, 27 Marques Maria Adelia...... 48 Mitsushige Murata...... 22, 45 Marra Alberto Maria...... 14, 29 Miyagawa Kazuya...... 17 Marti Fuster Berta...... 24 Miyashita Yohei...... 40 Martin Jennifer M...... 21 Miyata Satoshi...... 17, 25, 41 Martin Lisa...... 13 Miyauchi Takashi...... 18 Martin-Suarez Sofia...... 44 Miyawaki Hiroshi...... 40 Martinez Fernando Jose...... 11 Moghaddam Nima...... 41 Martinez Ines...... 48 Mogulkoc Nesrin...... 29 Martínez-Dolz Luis...... 35 Moiseeva Olga...... 24, 29 Martynyuk Tamila...... 35, 36 Mokin Egor...... 17 Maruyama Hidekazu...... 17, 18 Mokina Natalia...... 17 Masaharu Kataoka...... 22, 45 Moledina Shahin...... 21 61 AUTHORS AND TASK FORCES MEMBERS INDEX

Möllmann Christian...... 19 Ng Choo...... 13 Monassier Laurent...... 22 Nguyen Thomas...... 34, 40 Montani David...... 9, 13, 15, 16, 17, 18, 21, 22, 23, 30, 31, 42 Nichols Bill...... 20 Monti Enrico...... 31, 34, 35, 37, 40, 41, 42, 43, 48 Nichols William...... 8, 13 Morales-Cano Daniel...... 17 Nicholson Gail...... 49 Morell-Cabedo Salvador...... 41 Nicolls Mark R...... 8 Moreno Laura...... 17 Nisell Magnus...... 26, 33 Moreo Antonella...... 25 Nishimura Masaharu...... 29, 35 Morita Yoshiaki...... 44 Nishimura Rintaro...... 35, 46, 47 Moriyama Hidenori...... 24 Nitsche Alejandro...... 23 Moros Claudio...... 47 Nobuhiro Tahara...... 36 Morrell Nicholas W...... 8, 13, 16, 21 Nobuhiro Tanabe...... 17, 43 Moser Bernhard...... 43 Nobuhiro Yaoita...... 44 WORLD Motoji Yoshiki...... 24 Nogi Masamichi...... 17, 25, 39, 39, 41 Mouratoglou Sofia-Anastasia...... 26, 27 Noriaki Emoto...... 22, 42, 45 SYMPOSIUM Muecke Christian...... 16 Noriyuki Negi...... 45 ON Multing Jonas...... 33 Normand Patrick...... 39 PULMONARY Munehisa Bekki...... 36 Nossent Esther...... 15, 17 Murakami Noriko...... 12 Nötzold René Reiner...... 20 HYPERTENSION Murata Mitsushige...... 24, 44 Ntai Konstantina...... 31 Musca Francesco...... 25 Ntellos Christos...... 31 Mutlu Bulent...... 29 Ntiloudi Despina...... 31 Nice Naeije Robert...... 9, 23, 24, 38, 40 O’brien Gerald...... 39 February 27-28 / March 1, 2018 Naessén Tord...... 16 Ogawa Aiko...... 34 Nagel Christian...... 14, 39 Ogo Takeshi...... 12, 44, 44 Naing Pyi...... 41 Oh Seyeon...... 15, 20, 39 Nair Athira...... 47 Ohh Jin Kyung...... 40 Naito Akira...... 17, 35, 43, 46, 47 Ohira Hiroshi...... 29, 35 Naka Katerina...... 26, 27, 27 Ohta-Ogo Keiko...... 17 Nakamura Hiroyuki...... 29, 35 Ohtani Tomohito...... 40 Nakamura Kazufumi...... 49 Ohtsuki Tomohiro...... 25, 41 Nakanishi Michio...... 44, 44 Oka Teruaki...... 17 Nakanishi Norifumi...... 17 Okada Yoshinori...... 17, 25 Nakayama Kazuhiko...... 14, 46, 46 Okita Yutaka...... 14 Nakhleh Morad K...... 13, 16, 18, 30 Oksul Metin...... 25 Nakwan Narongsak...... 48 Oku Kenji...... 29, 35 Naohiko Nakanishi...... 46 Okumus Gulfer...... 30, 35 Naoki Okumura...... 28, 42 Oliva Fabrizio...... 40 Naoki Tamada...... 22, 42, 45 Olivares Araceli...... 48 Naseva Emilia...... 31 Olivier Sitbon...... 39 Nathan Steven D...... 37, 11 Olschewski Andrea J...... 8, 21 Natsina Kristiana...... 38 Olschewski Horst...... 11, 21, 38 Nattmann Phillip...... 33 Olsson Karen M...... 11 Nayakanti Sreenath Reddy...... 24 Omura Junichi...... 17, 25, 39, 39, 41 62 Newnham Michael...... 13, 21 Öngen Gül...... 44 AUTHORS AND TASK FORCES MEMBERS INDEX

Ongen Hurrem Gul...... 34 Patuzzo Giuseppe...... 49 Ongen Zeki...... 34 Pauciulo Michael...... 13 Onishi Hiroyuki...... 14, 45, 46 Pavlidis George...... 36 Orfanos Stylianos...... 19, 24, 26, 27, 31, 35, 36 Peacock Andrew J...... 11, 13, 21, 38 Orhan Gokcen...... 30 Peloquin Grace...... 14 Orlova Kristina...... 40 Pena Janethe De Oliveira...... 33 Osa-Sáez Ana...... 35 Pepke-Zaba Joanna...... 11, 13, 21, 32, 46 Osamu Yamada...... 14 Perdomo-Londoño Diana...... 41 Ota Masao...... 22 Perez Solène...... 13 Otake Hiromasa...... 14, 46 Perez-Vizcaino Francisco...... 17 Otshuki Tomohiro...... 39 Perna Enrico...... 40 Otsu Kazuya...... 18 Perrone Sergio...... 34 Oudiz Ronald J...... 9 Perros Frédéric...... 13, 15, 16, 17, 18, 22, 23, 30, 45 Ouwehand Willem H...... 21 Peter Dorfmüller...... 18, 23 WORLD Ouyang Pamela...... 19 Pezzuto Beatrice...... 24 Ozcan Kahraman Buse...... 31 Phan Carole...... 15, 18, 19 SYMPOSIUM Ozpelit Ebru...... 31 Phua Ghee Chee...... 26, 28, 43, 45 ON Ozsoy Ismail...... 31 Piccinino Cristina...... 16 PULMONARY P Ramos Roberta...... 23 Pinder Diane...... 19 Pacak Jozef...... 44 Piotr Podolec...... 33 HYPERTENSION Pacini Davide...... 44 Pistritto Anna Maria...... 23, 40 Padmanabhan Menon Divya...... 49 Pitsiou Georgia...... 26, 27, 34 Palabiyik Mert...... 26 Pitsis Antonios...... 31 Nice Palaiodimos Leonidas...... 36 Pittrow David...... 32 February 27-28 / March 1, 2018 Palazzini Massimiliano...... 11, 31, 34, 35, 37, 40, 41, 42, 43, 48 Planche Olivier...... 46 Palevsky Harold...... 19 Platt David...... 39 Palmisciano Amy...... 19 Playford David...... 30, 41 Pan Zixuan...... 20 Poble Paul-Benoit...... 18, 19 Panagiotidou Evangelia...... 26, 27, 34 Podolec Piotr...... 36, 44 Panzenböck Adelheid...... 46 Pollock Eks Wye...... 32 Papaioannou Andriana...... 35 Poms Abby...... 20 Papiris Spyros...... 35 Ponce Derek...... 19 Pappas Athanasios...... 19, 31, 35 Postadzhiyan Arman...... 31 Papy-Garcia Dulce...... 15 Pradhan Kabita...... 24 Parati Gianfranco...... 40 Preston Ioana R...... 10, 19 Park Han Ki...... 33, 34, 38 Prevot Grégoire...... 21 Park Hyukjin...... 44 Price Laura...... 26 Park Jae-Hyeong...... 40, 41 Prokopenko Inga...... 21 Park Jong Chun...... 44 Provencher Steeve...... 11 Park Taek Kyu...... 28 Pruett Janis...... 34 Park Young Hwan...... 33, 38 Publig Max...... 43 Parmentier Gilles...... 13 Pulido Tomas...... 10 Pasca Filippo...... 31, 34, 35, 37, 41, 42, 43, 48 Pullamsetti Soni...... 18, 19 Pasurivong Orapin...... 25 Pullamsetti Soni Savai...... 8, 16, 20, 24, 43 Patel Jigisha...... 37 Pussadhamma Burabha...... 25 63 AUTHORS AND TASK FORCES MEMBERS INDEX

Pyatin Vasily...... 17 Roscigno Robert...... 39 Pylawka Serhiy...... 16 Rosenkranz Stephan...... 11, 19, 31, 32, 33, 38, 39, 40 Quah Kevin...... 45 Ross James...... 24 Quarck Rozenn...... 18, 19, 45 Rossbach Oliver...... 19 Quatredeniers Marceau...... 16 Rotunno Mariangela...... 31, 34, 35, 37, 41, 42, 43, 48 Quilindro Alberto...... 47 Royal Mike...... 39 Rabinovitch Marlene...... 8, 17 Ruan Wen...... 26, 28, 43, 45 Raboisson Maire-Josee...... 48 Rubin Lewis J...... 8, 10, 12, 36 Radchenko Ganna...... 28, 36 Rucker-Martin Catherine...... 16, 23 Rådegran Göran...... 26, 30, 33 Rueda-Soriano Joaquín...... 35 Radhakrishnan Ramya...... 24 Rundqvist Bengt...... 33 Rahaghi Farbod...... 24 Ruopp Nicole...... 27 Rahaghi Franck...... 33 Russo Claudio...... 40 WORLD Rainisio Maurizio...... 10 Rygkov Anton...... 24 Rallidis Loukianos...... 35, 36 Ryo Konno...... 44 SYMPOSIUM Raman Subha...... 32 Ryosuke Kikuchi...... 28 ON Rammos Spyridon...... 26, 27, 31 Ryu Jeongwon...... 15, 20, 39 PULMONARY Rancati Julieta...... 48 S Ota-Arakaki Jaquelina...... 23 Ranchoux Benoit...... 15, 16, 18 Sa Silin...... 17 HYPERTENSION Raphaël Thuillet...... 15, 18 Sachiyo Igata...... 36 Rapp Ulf...... 18 Sadushi-Kolici Roela...... 35, 43, 45 Rasul Niazi Zahid...... 22 Safdar Zeenat...... 10 Nice Raymond Nicolas...... 16 Saidova Marina...... 35 February 27-28 / March 1, 2018 Raza Farhan...... 47 Saito Toshie...... 17 Reis Abílio...... 38 Saito Yoshiro...... 17 Reis e Sousa Caetano...... 23 Sakai Satoshi...... 17, 18 Reiss Irwin Karl...... 25 Sakao Seiichiro...... 17, 35, 46, 47 Remkova Anna...... 44 Sakata Yasushi...... 40 Reptova Adriana...... 25 Salazar Ylia...... 18 Reynaud-Gaubert Martine...... 21 Salgado Antonio...... 48 Rhodes Christopher J...... 21 Salmon Richard M...... 21 Richter Manuel...... 43 Salobir Barbara...... 45 Ridocci-Soriano Francisco...... 41 Samakovalis Christos...... 16 Rika Suda...... 43 Samarzija Miroslav...... 45 Rimouche Asma...... 24 San José Estépar Raúl...... 24 Rinaldi Andrea...... 31, 34, 35, 37, 40, 41, 42, 43, 48 Sánchez-Álvarez Sergio...... 41 Rintaro Nishimura...... 43 Sanders Jadyn...... 43 Riou Marianne...... 18 Sandqvist Anna...... 45 Ristic Arsen D...... 36 Sanfiorenzo Céline...... 21 Rizos Michalis...... 19, 31 Santos Mário...... 38 Roberts Kari...... 19 Saori Yamamoto...... 44 Rodriguez Viales Rebecca...... 14, 20 Sarasa Isobe...... 22, 45 Romer Lewis...... 15, 47 Sarashina Toshihiro...... 49 Romero Guadalupe...... 29 Sardella Angela...... 47 64 Rondelet Benoit...... 23 Sari Alper...... 25 AUTHORS AND TASK FORCES MEMBERS INDEX

Sasmaz Hatice...... 46 Shigetake Shimokata...... 28, 42 Satoaki Matoba...... 46 Shigetoyo Kogaki...... 14 Satoh Kimio...... 17, 25, 39, 41 Shih-Hsien Sung...... 23 Satoh Taijyu...... 17, 25, 39, 41 Shimizu Toru...... 39, 41 Satoh Toru...... 9, 14, 17, 43 Shimokawa Hiroaki...... 17, 25, 39, 41 Satomi-Kobayashi Seimi...... 46 Shin Yu Lim...... 33, 38 Satoshi Akagi...... 27 Shingo Kasahara...... 27 Savai Rajkumar...... 16, 18, 43 Shinke Toshiro...... 14, 46 Savale Laurent...... 10, 17, 31, 42 Shinkura Yuto...... 14, 46 Savci Sema...... 31 Shinobu Gamou...... 22 Sawa Yoshiki...... 40 Shinsuke Shimoyama...... 45 Saxer Stéphanie...... 16 Shiro Adachi...... 28 Scalia Gregory...... 30, 41 Shiro Ishikawa...... 14 Scelsi Laura...... 21 Shozaburo Doi...... 14 WORLD Schäfer Michal...... 48 Shumpei Mori...... 45 Schaffarich Michael...... 43 Shunsuke Tatebe...... 44 SYMPOSIUM Schermuly Ralph T...... 8, 18, 24, 43 Sicurello Maria...... 47 ON Scheuer Sarah...... 46 Siddique Mohammad Abdul Hai...... 17, 25, 39, 39, 41 PULMONARY Schini-Kerth Valérie...... 22 Sihuayro Ana...... 40 Schlesinger Robert...... 24 Simakova Maria...... 24, 29 HYPERTENSION Schmoranzer Mario...... 20 Simkova Iveta...... 25, 35, 42, 44, 45 Schwarzinger Ilse...... 43 Simonneau Gérald...... 8, 9, 12, 13, 15, 17, 31, 32, 33, 42, 46 Schwenger Vedat...... 39 Simpson Michael...... 13 Nice Screaton Nicholas...... 13 Sirenko Yurii...... 28, 36 February 27-28 / March 1, 2018 Se Yong Jung...... 48 Sitbon Olivier...... 10, 17, 18, 31, 42 Seeger Werner...... 11, 16, 18, 19, 20, 21, 24, 43 Skoro-Sajer Nika...... 35, 43, 45, 46 Seferian Andrei...... 13, 18 Skride Andris...... 38, 46 Seiichiro Sakao...... 17, 43 Šmite Daina...... 38 Seimi Satomi-Kobayashi...... 45 Snijder Repke...... 32 Sekine Ayumi...... 19 Snyder Michael...... 17 Semenza Gregg...... 16 Söderberg Stefan...... 45 Sener Yusuf Ziya...... 25 Son Kuk Hui...... 15, 20, 39 Senol Hande...... 47 Song Jie...... 14, 20 Sentürk Bihter...... 31 Song Jin Young...... 28 Seong Seok-Woo...... 40 Song Ju Sun...... 28 Sevinç Can...... 31 Song Shin-Jeong...... 38 Sewa Duu Wen...... 28, 43, 45 Sood Namita...... 36, 39 Sezgin Dilek...... 31 Soplopuco Christian...... 40 Shamardina Olga...... 21 Soranzo Nicole...... 13, 21 Shamdani Sara...... 15 Sorimachi Hidemi...... 48 Sharokh Taghavi...... 43 Soto Herman...... 48 Sheares Karen...... 13 Soubrier Florent...... 8, 15, 17, 21 Shen Lei...... 37 Sourla Evdokia...... 34 Shi Minyi...... 17 Southgate Laura...... 21 Shigeta Yohei...... 43 Southwood Mark...... 21 65 AUTHORS AND TASK FORCES MEMBERS INDEX

Souza Rogerio...... 9 Takehiro Igarashi...... 14 Spreemann Till...... 48 Takeshi Kawakami...... 45 Stagaki Eleni...... 26, 27, 31, 35 Takeuchi Kaori...... 14, 43 Stam Kelly...... 25 Takuwa Ayako...... 40 Stanopoulos Ioannis...... 34 Tamada Naoki...... 14, 46 Stavros Hadjimiltiades...... 27 Tamura Yuichi...... 10, 28, 32 Stenmark Kurt R...... 8 Tan Ju Le...... 26, 28, 43, 45 Stepffer Carolina...... 48 Tanabe Nobuhiro...... 17, 35, 46, 47 Stepniewski Jakub...... 36, 44 Tanaka Hiroshi...... 14 Steringer-Mascherbauer Regina...... 45 Tanaka Mariko...... 22 Stevens Scott...... 43 Tanese Nikita...... 31, 34, 35, 37, 40, 41, 42, 43, 48 Stewart Traci...... 49 Taniguchi Yu...... 46 Stockbridge Norman...... 10 Tapson Victor F...... 12 WORLD Storn Samantha...... 18 Taran Irina...... 35, 36 Strange Geoff...... 30, 41 Tatsumi Koichiro...... 17, 28, 35, 46, 47 SYMPOSIUM Strautmane Sintija...... 46 Tatsuo Aoki...... 44 ON Stylianos Orfanos...... 36 Tatsuya Nishii...... 45 PULMONARY Su Po-Lan...... 42 Taylor Shalina...... 17 Suberbielle Caroline...... 13 Tcherakian Colas...... 18 HYPERTENSION Suda Rika...... 35, 46, 47 Tedford Ryan J...... 11 Sugawara Eri...... 29, 35 Ten Freyhaus Henrik...... 19, 40 Sugiura Toshihiko...... 35, 46 Teoh Jeremy...... 26, 28 Nice Sumer Celik...... 30, 35 Tesson Laurent...... 16 February 27-28 / March 1, 2018 Sumner Kelli...... 43 Thakrar Mitesh...... 33 Sunamura Shinichiro...... 17, 25, 39, 41 Thal Serge...... 19 Sung Shih-Hsien...... 26 Thuillet Raphaël...... 15, 18, 19 Suntharalingam Jay...... 21 Tian Xia...... 24 Suriany Silvie...... 19 Tielemans Birger...... 18, 19, 45 Suzuki Kota...... 41 Tinazzi Elisa...... 49 Suzuki Yoko...... 22 Titov Yevhen...... 36 Swietlik Emilia...... 21 Tocci Alejandro...... 47 Swiston John...... 41 Tomohisa Nakamura...... 36 Sydykov Akylbek...... 24 Tomotaka Nakayama...... 14 Szmuszkovicz Jacqueline...... 19 Torbicki Adam...... 9, 45 Taboada Dolores...... 13 Torres Fernando...... 9, 36 Tacchella Gloria...... 49 Torres Isabel...... 47 Tacy Theresa...... 22, 28, 47 Toshihiko Sugiura...... 17, 43 Taghavi Shahrokh...... 43 Toshihiro Sarashina...... 27 Takagi Kae...... 33 Toshio Nakanishi...... 14 Takahiro Hiraide...... 22 Toshiro Shinke...... 42, 45 Takahisa Kondo...... 28, 42 Toshner Mark R...... 13, 21 Takaki Hiwasa...... 17 Toti Florence...... 22 Takama Noriaki...... 48 Toumpourleka Maria...... 26, 27 Takashi Kawakami...... 22 Toyoaki Murohara...... 28, 42 66 Takayuki Jujo...... 17 Toyoda Yoshiya...... 47 AUTHORS AND TASK FORCES MEMBERS INDEX

Treacy Carmen M...... 21 Varoudi Mary...... 36 Trejo-Velasco Blanca...... 41 Varughese Rhea...... 33 Trembath Richard C...... 8, 13, 21 Vasileios Grosomanidis...... 27 Tresorier Romain...... 21 Vasiliadis Konstantinos...... 31 Tretyn Aleksandra...... 24 Vaughn Toby...... 39 Triantafyllidi Helen...... 36 Vazquez Haydee...... 47 Tsagkaris Hraklis...... 36 Velchev Vasil...... 31, 37 Tsagkaris Iraklis...... 35, 36 Ventetuolo Corey...... 19 Tsai Yi-Shan...... 30 Viethen Thomas...... 31, 38 Tsang Yuen...... 34 Villa George...... 32 Tsangaris Iraklis...... 19, 26, 27, 32 Villarroel Ruth...... 40 Tsantes Argyrios...... 19 Vinhas Maria...... 30 Tsioufis Konstantinos...... 31 Vinhas Maria Candida...... 16 Tsubata Hideo...... 46 Vitola Barbara...... 46 WORLD Tsuboi Yasunori...... 14, 46 Vizza Carmine Dario...... 24 Tsugu Toshimitsu...... 24, 44 Vocelle Matthieu...... 13, 16 SYMPOSIUM Tsui Steven...... 13 Vonk Noordegraaf Anton...... 9, 15, 17, 18, 21, 38 ON Tsuji Akihiro...... 44 Vrigkou Eleni...... 19 PULMONARY Tsujino Ichizo...... 29, 35 Wada Yosuke...... 42 Tsutomu Saji...... 14 Wade Rolin...... 34 HYPERTENSION Tsutsui Hiroyuki...... 22 Wagenaar Allard...... 18, 19, 45 Tu Ly...... 15, 18, 19, 28, 30 Waisfisz Quintin...... 21 Tufekcioglu Omac...... 46, 47 Waligóra Marcin...... 36, 44 Nice Turner Stewart...... 36 Walsh Thomas...... 19 February 27-28 / March 1, 2018 Tyrka Anna...... 36 Walsworth Anna...... 13 Tzifa Afroditi...... 31 Wang Lingli...... 17 Uchida Shizuka...... 19 Wang Mouer...... 17 Ueda Jin...... 44 Wargin William...... 39 Ulander Frida...... 16 Washko George...... 24 Ulrich Sylvia...... 16, 20, 32, 38 Watanabe Hiroshi...... 28 Upton Paul D...... 21 Weatherald Jason...... 31, 33, 42 Ushiki Atuhito...... 22 Weber Christine...... 20 Utako Yokoyama...... 27 Weigert Andreas...... 18 Vachiéry Jean-Luc...... 11, 24, 32, 34, 40 Weinberg Isolde Maria...... 43 Vaidya Anjali...... 47 Weirick Tyler...... 19 Valasarajan Chanil...... 19 Weiß Astrid...... 24 Valieva Zarina...... 36 Weissmann Norbert...... 11, 16, 24 Valkovicova Tatiana...... 25, 42, 44 Wells Athol U...... 37 Valsarajan Chanil...... 16 Wen Sewa Du...... 26 Van Bezu Jan...... 18 Werner Astrid...... 19 Van Duin Richard WB...... 15, 23, 25 Wharton John...... 21 Van Hulst Jennifer...... 23 Whitaker Wolf Plínio José...... 28 Van Loo Geert...... 23 Whitehorn Deborah...... 21 Vantler Marius...... 19 Whittle Brendan...... 37 Varela Brenda...... 23 Wiedenroth Christoph...... 43 67 AUTHORS AND TASK FORCES MEMBERS INDEX

Wietelmann Astrid...... 16 Yoshihide Mitani...... 14 Wikström Gerhard...... 16 Yoshihiro Fukumoto...... 36 Wilhelm Jochen...... 43 Yoshihiro Kamimura...... 28, 42 Wilkins Martin R...... 10, 13, 21 Yoshihisa Nakano...... 28, 42 Williams Paul...... 9 Yoshino Hideaki...... 14, 43 Williams Rex...... 39 Yoshiya Toyoda...... 47 Williams Trevor...... 40, 42 Yu Chang...... 20 Winkler Tilo...... 24 Yuasa Shinsuke...... 44 Wirtz Hubert...... 32 Yuichi Tamura...... 15 Wojciech Magon...... 33 Yuichiro Fujieda...... 35 Wolf Janine...... 18 Yuji Itabashi...... 22, 45 Wolf Matthias...... 29 Yuki Aimi...... 22 Woller Scott...... 43 Yuto Shinkura...... 42, 45 WORLD Wong Brad A...... 12 Yuu Izawa...... 45 Wong Maggie...... 26, 28 Zamanian Roham...... 10 SYMPOSIUM Wort Stephen J...... 21, 26 Zanaboni Jacopo...... 16 ON Wort Stephen John...... 13 Zehendner Christoph...... 19 PULMONARY Wuyts Wim...... 37 Zeiher Andreas...... 19 X C Fonseca Angelo...... 23 Zhao Carol...... 38 HYPERTENSION Xavier Jais...... 39 Zhao Zhixin...... 17 Yakut Idris...... 46 Zhyvylo Iryna...... 28, 36 Yamamoto Hiroshi...... 22 Zuffa Elisa...... 31, 34, 35, 37, 41, 42, 43, 48 Nice Yamamoto Keiko...... 47 February 27-28 / March 1, 2018 Yamauchi-Takihara Keiko...... 40 Yanaka Ken-Ichi...... 46 Yanaka Kenichi...... 14, 46 Yang Jung Hoon...... 28 Yaoita Nobuhiro...... 17, 25, 39 Yap Jonathan...... 26, 28, 43, 45 Yasuda Satoshi...... 44 Yasuda Shinsuke...... 29, 35 Yasunori Tuboi...... 45 Yasuo Masanori...... 22 Yasuo Ono...... 14 Yates Katherine...... 21 Yaylali Yalin Tolga...... 41, 42, 47 Yerabolu Naga Dinesh Reddy...... 19 Yilancioglu Resit Yigit...... 31 Yildizeli Bedrettin...... 44 Yilmaz Samet...... 47 Yohei Shigeta...... 14 Yoichi Sugiyama...... 36 Yoichiro Matsuoka...... 42 Yoon Hyun Ju...... 44 68 Yoshiaki Kitaguchi...... 42 SPONSORS

WORLD SYMPOSIUM ON PULMONARY HYPERTENSION

Nice February 27-28 / March 1, 2018

69 NOTES

WORLD SYMPOSIUM ON PULMONARY HYPERTENSION

Nice February 27-28 / March 1, 2018

70 NOTES

WORLD SYMPOSIUM ON PULMONARY HYPERTENSION

Nice February 27-28 / March 1, 2018

71 The Symposium Secretariat

I&C s.r.l. Via Andrea Costa, 202/6 40134 Bologna (IT) Stefania Parolari and Giulia Delia Ph: +39 - 051.614.4004 Fax: +39 - 051.614.2772 @: [email protected] www.wsph2018.com