Gallbladder Function Predicts Subsequent Biliary Complications In

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Gallbladder Function Predicts Subsequent Biliary Complications In Tsai et al. BMC Gastroenterology (2018) 18:32 https://doi.org/10.1186/s12876-018-0762-6 RESEARCH ARTICLE Open Access Gallbladder function predicts subsequent biliary complications in patients with common bile duct stones after endoscopic treatment? Tzung-Jiun Tsai1 , Hoi-Hung Chan1,2,4,5,6*, Kwok-Hung Lai1,2, Chih-An Shih1, Sung-Shuo Kao1,2, Wei-Chih Sun1, E-Ming Wang1, Wei-Lun Tsai1,2, Kung-Hung Lin1, Hsien-Chung Yu1, Wen-Chi Chen1,2, Huay-Min Wang1, Feng-Woei Tsay1, Huey-Shyan Lin3, Jin-Shiung Cheng1 and Ping-I Hsu1,2 Abstracts Background: In patients with common bile duct stones (CBDS) and intact gallbladder, further management for the gallbladder after the CBDS clearance is still controversial. The relationship between gallbladder motility and the biliary complications were seldom discussed. Our study is to predict the subsequent biliary complications by gallbladder function test using fatty meal sonography (FMS) in patients with CBDS who had been treated by endoscopic retrograde cholangiopancreatography (ERCP). Methods: Patients with an intact gallbladder and CBDS after endoscopic clearance of bile duct were enrolled. Patients received a fatty meal sonography after liver function returned to normal. The fasting volume, residual volume, and gallbladder ejection fraction (GBEF) in FMS were measured. Relationships of patients’ characteristics, gallbladder function and recurrent biliary complication were analyzed. Results: From 2011 to 2014, 118 patients were enrolled; 86 patients had calculus gallbladders, and 32 patients had acalculous gallbladders. After a mean follow- up of 33 months, 23 patients had recurrent biliary complications. Among 86 patients with calculus gallbladder, 15 patients had spontaneous clearance of gallbladder stones; 14 patients received cholecystectomy due to acute cholecystitis or recurrent colic pain with smooth postoperative courses. In the follow up period, six patients died of non-biliary causes. The GBEF is significant reduced in most patients with a calculus gallbladder in spite of stone color. Calculus gallbladder, alcohol drinking and more than one sessions of initial endoscopic treatment were found to be the risk factors of recurrent biliary complication. Conclusions: Gallbladder motility function was poorer in patients with a calculus gallbladder, but it cannot predict the recurrent biliary complication. Since spontaneous clearance of gallbladder stone may occur, wait and see policy of gallbladder management after endoscopic treatment of CBDS is appropriate, but regular follow- up in those patients with risk factors for recurrence is necessary. Keywords: Endoscopic retrograde cholangiopancreatography, Gallbladder dyskinesia, Gallstones, Recurrent biliary complications * Correspondence: [email protected] 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China 2School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China Full list of author information is available at the end of the article © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Tsai et al. BMC Gastroenterology (2018) 18:32 Page 2 of 9 Background Patients Endoscopic sphincterotomy (EST), endoscopic papillary Patients with an intact gallbladder and CBDS, including balloon dilation (EPBD), and endoscopic papillary large patients with biliary pancreatitis, who had received endo- balloon dilation (EPLBD) are commonly used methods scopic clearance of bile duct and refused for elective chole- to enlarge the biliary orifice and remove common bile cystectomy, were enrolled. Patients who had recurrent duct stones (CBDS) [1, 2]. In patients with CBDS and an CBDS, association with intrahepatic stones or malignant intact gallbladder, the management of the gallbladder diseases, first detected recurrent biliary complication during after endoscopic clearance of the bile duct is controver- the follow-up period (within six months) after clearance of sial. Some studies suggest that elective cholecystectomy bile duct, elective cholecystectomy subsequently for non- after endoscopic clearance of CBDS may reduce the late biliary cause, or refusals of follow-up were excluded. biliary complications [3–5], but other studies have not confirmed the same benefits [6–8]. Tsujino et al. found Endoscopic treatment that patients either with cholecystectomy before EPBD All the endoscopic treatments were performed under or with a calculus gallbladder had higher rate of CBDS local anesthesia of the pharynx with 10% xylocaine, recurrence than those with elective cholecystectomy intramuscular injection with 40 mg hyosine-N butybro- after EPBD or an acalculous gallbladder (10.8% and mide and 25-50 mg meperidine were administered as 15.6% vs. 2.4% and 5.9%, respectively) [9]. In our previ- premedication. Endoscopic retrograde cholangiopancrea- ous study, patients with calculus gallbladder exhibited a tography (ERCP) was performed in the standard manner higher incidence of an overall delayed biliary complica- using a side-view endoscope (JF240, JF260; Olympus tions than those with acalculous gallbladder and chole- Optical Corporation, Tokyo, Japan). End-view endoscope cystectomy both before and after endoscopic treatment (GIF1T, GIFXQ, Olympus Optical Corporation, Tokyo, for CBDS. However, the incidence of recurrent CBDS in Japan) was used in patient with prior Billroth II gastrec- patients with calculus gallbladder was similar to that in tomy. Endoscopic large balloon dilation (CRE balloon the cholecystectomized patients, but higher than in pa- 5.5 cm in length,1–1.2 cm/1.2–1.5 cm/1.5–2.0 cm in tients with acalculous gallbladder [10]. Since slow biliary diameter; Boston Scientific Corp, Ireland) usually per- emptying contribute to recurrent CBDS even after endo- formed to enlarge the papillary orifice. Using fluoroscopic scopic sphincterotomy [11], the gall bladder left in situ and endoscopic guidance, the balloon was inflated with di- may be able to wash away bile and prevent recurrence luted contrast solution up to the optimal size for 2–6min or flush out newly produced stones [12]. Although according to the patients’ condition and tolerance. In the filling and emptying of the gallbladder may be order to minimize the risk of perforation, the size of bal- impaired in patients with gallstones [13], improved loon should not be exceeded the diameter of the CBD gallbladder emptying and reduced lithogenicity of bile [17]. In the patients with difficult deep cannulation, precut have been reported after endoscopic sphincterotomy followed by full sphincterotomy using needle knife sphinc- [14, 15]. Sugiyama et al. found that EPBD did not affect terotome(KD-V451 M, Olympus Co. Japan) and conven- gallbladder motility in the long-term (five years) [16]. tional sphincterotome (Truetome 39, Boston Scientific However, the relationship between gallbladder status, mo- Crop, Ireland) were performed. After enlargement of pap- tility and recurrent biliary complications after endoscopic illary orifice, the CBDS were retrieved by basket (FG treatment has seldom been discussed. V22PR, FGV21PR, Olympus Co. Japan) until completely The aim of our study is to evaluate the gallbladder clearance of bile duct. If the stones were larger than the function and outcome of patients with CBDS and an in- distal bile duct, they were fragmented by lithotripter tact gallbladder after endoscopic clearance of the bile (BML-V232QR-30, Olympus Co. Japan) before extraction. duct, and to evaluate the relationship between the gall- bladder motility, gallstone status, and other factors that Stone color stratification affect the recurrence of biliary complications. According to natural history of gallstones and CBD stones, we classified the stones into primary and secondary CBD stone according to the stone color [18, 19]. The secondary Methods CBD stone were white cholesterol or black pigment stone, This study was approved by the Institutional Review which forms primary in gallbladder and secondary migrate Board of Kaohsiung Veterans General Hospital and into CBD. The primary stone was brown pigment stone, was performed according to the Helsinski Declaration. which usually forms primary in CBD. The protocol was registered in the Government Research Bulletin according to the law of Taiwan. Informed Follow-up studies written consent was obtained from all participants in Patients were followed in a special clinic every two this study. weeks soon after discharge. Patients received a fatty meal Tsai et al. BMC Gastroenterology (2018) 18:32 Page 3 of 9 sonography (FMS) to evaluate the gallbladder function follow-up, and one with recurring biliary complication when their liver function returned to normal. Patients before receiving gallbladder function test (Fig. 1). were then scheduled for follow-up visits every three Among the 118 patients, 76 were male and 42 patients months. During each visit, a blood sample was taken for were female. The mean
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