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TABLE OF CONTENTS page Statement of ISACB Mission; Executive Committee and Advisory Board Members ..................................................2 Letters from the ISACB Program and Local Arrangements Chair and ISACB President .........................................................3 General Information And Program Summary University College, London Map ................................................................................ 4-5 ISACB 13th Biennial Meeting Schedule at a Glance ....................................................6 ISACB 13th Biennial Meeting Satellite Symposium .....................................................7 ISACB 13th Biennial Meeting Program .................................................................... 8-12 Young Investigator Awards ...........................................................................................13 Oral Presentation Abstracts: Session 1 ................................................................ 14-16 Oral Presentation Abstracts: Session 2 ................................................................ 17-19 Oral Presentation Abstracts: Session 3 ................................................................ 20-21 Oral Presentation Abstracts: Session 4 ................................................................ 22-24 Oral Presentation Abstracts: Session 5 ......................................................................25 Posters Presentation Abstracts ............................................................................. 26-55 ISACB New Membership ..............................................................................................56 Notes ..............................................................................................................................57 ISACB’S 2012 BIENNIAL MEETING 1 THE INTERNATIONAL SOCIETY FOR APPLIED CARDIOVASCULAR BIOLOGY Provides a forum for communicating issues related to the translation of innovative cardiovascular research from the laboratory to the bedside; — Uniquely nurtures strong face-to-face communication and is a most effective alliance among academic scientists, clinicians and industry-based scientists; — Serves as a key forum for discussion of solutions to difficult clinical, scientific and technical challenges engendered by the validation of the efficacy and safety of diagnostic imaging and laboratory tests, and therapeutic procedures and devices, including advanced biomaterials, endovascular techniques, stents, and vascular grafts, valves, and cardiac assist and other innovative devices. International Society for Applied Cardiovascular Biology Executive Committee – 2010/2012 OFFICERS President Secretary-Treasurer Howard P. Greisler, M.D. David Vorp, Ph.D. Maywood, Illinois, USA Pittsburgh, Pennsylvania, USA — Elena Aikawa, M.D., Ph.D. Steven Schmidt, Ph.D. Boston, Massachusetts, USA Akron, Ohio, USA Masanori Aikawa, M.D., Ph.D. Frederick J. Schoen, M.D., Ph.D. Boston, Massachusetts, USA Boston, Massachusetts, USA Julie Campbell, M.D. David Williams, Ph.D. Brisbane, Australia Liverpool, U.K. Elliot Chaikof, M.D., Ph.D. ADVISORY BOARD Boston, Massachusetts, USA Teddy Fishlein, M.D. Adrian Chester, M.D. Nuremberg, Germany Harefield, England, U.K. Manfred Deutsch, M.D. Arthur Coury, Ph.D. Vienna, Austria Boston, Massachusetts, USA Roland Fasol, M.D. Simon Hoerstrup, M.D., Ph.D. Gobelsburg, Austria Zurich, Switzerland Bo Risberg, M.D., M.B.A. Robert M. Nerem, Ph.D. Gothenburg, Sweden Atlanta, Georgia, USA Bauer Sumpio, M.D., Ph.D. Teruo Okano, Ph.D. New Haven, Connecticut, USA Tokyo, Japan Magdi Yacoub, M.D. Harefield, Middlesex, United Kingdon 2 ISACB.ORG MESSAGES FROM ISACB Dear Members Dear Colleagues, and Friends of Welcome to the International Society for Applied the International Cardiovascular Biology’s (ISACB) 13th Biennial Society for Applied Meeting in London, England. I would like to Cardiovascular Biology, acknowledge the ISACB Program Committee and Welcome to the ISACB’s 13th Local Arrangement Committee for their hard work in Biennial Meeting in organizing this extraordinary meeting. Without their post-Olympic London! efforts, this event would not have been possible. The meeting is situated The conference will focus on five critically important entirely within Bloomsbury, areas of active and evolving research in translational an historic and elegant area of central London. cardiovascular biology, with a full session devoted to each. The session Bloomsbury is characterized by its Georgian and themes are 1) Molecular and Cardiovascular Imaging, 2) Developmental Victorian architecture arranged around beautiful Cardiovascular Biology in Children and Adults, 3) Cell-Cell and Cell- mature city gardens, and an ‘intellectual’ past and Matrix Interactions in Cardiovascular Biology, 4) Emerging Medical present, for example containing University College Technologies in Cardiovascular Repair and Therapeutics – Proteomics London, the British Museum, and the houses of and Epigenetics and 5) Critical Issues in Tissue Engineering: Construct Charles Dickens and Virginia Woolf. Vascularization and Scaffold-Generated Signaling. Each of the invited On Wednesday afternoon there will be a Satellite speakers in the scientific program, 3-4 per session, is an expert in his/ Meeting hosted by the Royal Free London Hospital her field and the invited talks are accompanied by 21 papers selected in the Anatomy Department of UCL with the Keynote by the Program Committee from proffered abstracts detailing innovative Lecture “Self- Assembled ex-vivo Engineered research. Additionally, two exciting panel discussions have been Cardiovascular Tissues to Study Mechanisms of organized – one on Friday addressing Regulatory Issues and Evaluation Disease and Drug Toxicity” given by Kevin Parker at Strategies for the Next Generation of Cardiovascular Devices and the 6:00 p.m. Directly following this the Reception begins other on Saturday focused on Grand Challenges in Applied Cardiovascular a short stroll away in UCL’s historic Portico. Biology. A dedicated and manned poster session on Saturday morning will include poster presentations based on proffered abstracts accepted The main ISACB Meeting starts on Thursday by the Program Committee based on scientific merit and is an important morning a short distance away in the Kennedy component of the program. I strongly encourage all participants to view Lecture Theatre complex within UCL’s Institute of the posters, which will be up throughout the meeting and to address Child Health. The scientific focus of the meeting discussion of the posters to the authors at the dedicated poster session. will be on Molecular and Cardiovascular Imaging, An exciting Satellite Meeting on Wednesday entitled Genetics, Metabolism Developmental Cardiovascular Biology in Children and Repair in Cardiovascular Disease has been organized by Janice Tsui and Adults, Lifetime Management of Arterial and George Hamilton and colleagues from the University College London Disease, Cell-Cell and Cell-Matrix Interactions in in coordination with the ISACB. Cardiovascular Biology, Critical Issues in Tissue Engineering, Biomaterials in the Development of ISACB and its Biennial Meetings are organized to bring together experts Small Diameter Vascular Conduits and Heart Valves in applied cardiovascular biology from wide and often seemingly Emerging Medical Technologies in Cardiovascular disparate backgrounds including academia, industry and government. Repair and Therapeutics – Proteomics and We strive to promote dialogue and collaborations between clinicians and Epigenetics, and Inflammation, Adaptive Immunity scientists, recognized scientific leaders and trainees, and among cell and and Hypertension. There will a mix of invited molecular biologists, pathologists, engineers, biomaterials researchers, internationally recognized experts, scientific surgeons, radiologists and physicians and others whose work addresses presentations and a Dedicated Poster Session. fundamental aspects of applied cardiovascular biology. While each of these groups makes important contributions to the field, ISACB believes As always the ISACB aims to foster knowledge that only the integration of these individual scientific arenas can ultimately transfer by keynote lectures and updates, cross- generate profound advances in our understanding of the pathobiology and fertilisation of ideas and disciplines, scientific the development of novel efficacious diagnostic therapeutic modalities. and clinical interaction to the advancement of While the ambitious program is built around lectures from carefully international research in cardiovascular disease. selected speakers, the success of the meeting is dependent upon free The faculty is truly international and leading edge flowing thought-provoking discussion and debate among all in attendance in their fields. The Society’s aim is also to foster and the generation of cross fertilizing new collaborations and new friendship and the venue is particularly well adapted synergies that generate improved therapies for heart and vascular disease. to facilitate this. All of the venues and hotels are situated within Bloomsbury and within walking London is a dynamic city and Bloomsbury is centrally situated making distance. There are many beautiful gardens, places exploration of the city quite accessible. Bloomsbury has a remarkable of interest, old pubs and a host of affordable literary heritage and the British Museum is a short walk away from the restaurants reflecting almost every cuisine.