Cardioversion of Atrial Fibrillation: How and When? Downloaded from by Guest on 29 September 2021
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European Heart Journal Supplements (2003) 5 (Supplement H), H40—H44 Cardioversion of atrial fibrillation: how and when? Downloaded from https://academic.oup.com/eurheartjsupp/article/5/suppl_H/H40/527907 by guest on 29 September 2021 Ph. Ricard, K. Yaïci, J.P. Rinaldi, M. Bergonzi and N. Saoudi Division of Cardiology, Centre Hospitalier Princesse Grace, Monaco Restoration of sinus rhythm in patients with persistent atrial fibrillation (AF) can be KEYWORDS Antiarrhythmic agents; achieved either by pharmacological or electrical cardioversion. Pharmacological Anticoagulant therapy; cardioversion is effective especially when the duration of AF is short (<7 days). In Atrial fibrillation; contrast for long duration episodes external cardioversion is the technique of Biphasic waveform; choice. The success rate ranges from 64 to 96%. The development of new Electrical cardioversion defibrillators delivering shocks with biphasic waveforms is associated with a higher success rate with lower energies. For some patient who had failed external cardioversion, internal cardioversion should be proposed. One major concern is the prevention of embolic complications. For this purpose, long term (>3 weeks) anticoagulation with warfarin or short term anticoagulation with heparin when the presence of atrial thrombus has been ruled out by transoesophageal echocardiogram has been shown to be effective. © 2003 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved Introduction serious adverse events, especially ventricular arrhythmias, can occur. In contrast, electrical CV Two different strategies are available in the has been shown to be safe and effective, and it is management of patients with persistent atrial therefore the technique of choice when AF is fibrillation (AF). The first consists of restoration persistent. It is important to recall that the and maintenance of sinus rhythm, whereas the prevention of embolic complications should be the second permits AF while controlling ventricular same whatever technique of CV is chosen. The rate. Although the superiority of the first strategy present review focuses on electrical CV of AF. relative to the other has not been clearly demonstrated,1,2 restoration of sinus rhythm is a desirable end-point. Reasons to prefer restoration Technical aspects of external and maintenance of sinus rhythm are the relief of cardioversion symptoms, prevention of tachycardia induced cardiomyopathy and prevention of thromboembolic Several techniques of electrical CV have been complications. Cardioversion (CV) of AF can be described. Although external CV is the most achieved with the use of antiarrhythmic drugs or commonly used technique, internal CV can be with electrical shocks. Pharmacological CV is beneficial in some patients. Regardless of which widely used for AF of short duration (<7 days). Its technique is chosen, R-wave synchronization of efficiency is less than that of electrical CV, and shocks is mandatory to avoid induction of ventricular arrhythmias, which may occur if the Correspondence: Ph. Ricard, MD, Division of Cardiology, Centre shocks are delivered on the T wave. Knowledge of Hospitalier Princesse Grace, avenue Pasteur, Monaco the technical aspects of CV is important because (Principauté) 98000 they affect the success rate with shocks. 01520-765X/03/0H0040 + 05 $35.00/0 © 2003 The European Society of Cardiology, Published by Elsevier Science Ltd. All rights reserved. Cardioversion of atrial fibrillation: how and when? H41 A high-energy impulse of short duration is Table 1 Technical features affecting the success rate of delivered through the chest using two electrodes. external cardioversion The density of current reaching the heart depends Position and size of the electrodes on the electrical current delivered and on the Contact between skin and electrodes resistance of the heart, the rib cage and the skin. Pressure on electrodes Therefore, several technical factors are involved Energy and number of shocks delivered in the success of external CV (Table 1). Waveform of the shocks The position and size of the electrodes are Thoracic impedance (obesity, lung disease, etc.) crucial for optimal results. Two types of electrodes are available: paddles and self-adhesive Downloaded from https://academic.oup.com/eurheartjsupp/article/5/suppl_H/H40/527907 by guest on 29 September 2021 electrodes. The latter allow the choice of any the serum level of myocardial enzymes. However, position, especially anterior-posterior, with in a recent study in 72 patients given an average optimal contact between skin and electrodes, shock energy in excess of 400 J, the serum levels whereas the former makes it possible to apply of troponin T and troponin I did not vary pressure on the electrodes. The optimal electrode significantly but the level of creatine kinase-MB size ranges from 8 to 12 cm.3 It has been shown increased after the shocks in 10% of the patients.9 that, when small electrodes are used, the current The increase in concentration of creatine kinase- density is 20 times greater between the paddles MB was correlated with the energy delivered. than at the margin of the heart.4 Therefore, this Most external defibrillators deliver a high current density between electrodes can monophasic damped sine waveform. However, induce myocardial injury. Alternatively, when the biphasic waveforms, in the implantable electrodes are too large the current density cardioverter—defibrillator, have been shown to be through the heart is too low to achieve CV. In a associated with lower defibrillation thresholds as randomized controlled study of 301 patients, compared with the monophasic waveforms. Their Botto et al.5 compared an anterior-lateral paddle use for external CV has provided encouraging position (right infra-clavicular and ventricular results. Two types of biphasic waveforms are apex) with an anterior-posterior paddle position available for external CV: rectilinear and (sternum and left scapular). When high-energy truncated exponential (Fig. 1). Only three studies shocks (>4 J/kg) were delivered, the anterior- dealing with external CV with biphasic waveforms posterior location was associated with a higher have been published to date. In a prospective success rate (87%) than with the anterior-lateral single-centre study, Ricard et al.10 demonstrated position (76%). In contrast to this, Kerber et al.6 that a 150 J impedance-compensated exponential did not find any significant difference between biphasic waveform shock was more effective than these two positions. Because the superiority of a 150 J monophasic shock (success rate 86% vs one position compared with the other has not 59%; P = 0.02). If sinus rhythm was not restored, been clearly demonstrated, it is suggested that if then a second 150 J biphasic shock or a 360 J one position fails then the other should be tried. monophasic shock was delivered, resulting in a The energy and number of shocks delivered are cumulative percentage of patients in sinus rhythm important for optimal outcome. In a prospective of 96% for the biphasic group vs 92% for the study conducted in 198 patients, Ricard et al.7 monophasic group (no significant difference). A showed that the cumulative percentage of CV was double-blind prospective multicentre study 22% for shocks of 40—50 J, 48% for those of 80— demonstrated the superiority of the biphasic 100 J, 75% for those of 160—200 J and 96% for waveform for shocks with energies lower than 200 those of 360 J. Therefore, it is recommended that J (i.e. 100, 150 and 200 J).11 The cumulative one starts with a first shock of 200 J. This strategy percentages of patients in sinus rhythm after allows a high success rate while keeping completion of the protocol (200 J biphasic shock vs cumulative energies as low as possible. The reason 360 J monophasic shock) were 91% in the biphasic to select the lowest effective energy is that high- group and 85% in the monophasic group (no energy shocks may be associated with some significant difference). Rectilinear biphasic potential side effects. Experimental studies have waveform was used in the third study.12 The shown a clear relationship between high energies sequence of the shocks was 70, 120, 150 and 170 J and myocardial injury. For example, the for the biphasic group and 100, 200, 300 and 360 J deleterious haemodynamic effect of three shocks for the monophasic group. In that study the of 50 J is very low.8 This is in keeping with the cumulative success rates were 94% in the biphasic results of some clinical studies that showed either group and 79% in the monophasic group; in a transient ST-segment elevation or an increase in contrast to the two previous studies, the H42 Ph. Ricard et al. (a) 100 Damped sine Exponential 80 v v 60 40 Patients (%) Patients 20 0 Downloaded from https://academic.oup.com/eurheartjsupp/article/5/suppl_H/H40/527907 by guest on 29 September 2021 CV 1 min 2 weeks 1 year Duration (ms) Duration (ms) Time (b) Rectilinear Exponential Fig. 2 Proportion of patients in sinus rhythm after electrical cardioversion. (From Tieleman et al.16) v v 96%.7,14 This difference can be accounted for by differences in the patients studied and the definition of success. For example, in some studies the occurrence of at least two consecutive P waves is defined as success,11 whereas in others success means sinus rhythm 3 days after CV.15 The latter definition appears less accurate because it Duration (ms) Duration (ms) does not allow distinction between early recurrence of AF and failure of the technique. Fig. 1 1 (a) Monophasic and (b) biphasic waveforms available Although the success rate with CV is high, for external cardioversion and defibrillation. recurrence of AF is common, especially during the first 2 weeks following the procedure (Fig. 2).16 It is difference in this study was statistically significant estimated that early recurrence of AF, within 2 min (P = 0.005). In the study, 50% of the patients who after the shock, occurs in about 5—10% of cases.